Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M10489 GO_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 204/264 Gene Ontology BP GO:0050808 4.40233145241256e-26 1.57569601908274e-23 55 432.090909090909 54 4.00211950219324e-27 3 2.76991927163919 2.95787251535188 1 76.283981873524 54 1612 5 3 1099 8 980 223 689 51 29 2 M11591 GO_IRON_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_TRANSPORT.html The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/73 Gene Ontology BP GO:0006826 2.88224930010487e-08 3.72894192114222e-07 5 740.545454545455 55 2.62022667078691e-09 1 1.82793291326035 -1.84801407569722 -1 14.1083199159299 1 410 2314 2179 55 1 4 41 358 2741 42 3 M15728 GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. 12/23 Gene Ontology BP GO:0016338 6.66679054653895e-09 1.15748419451663e-07 60 527.090909090909 66 6.06071869703794e-10 3 4.32321686289073 -4.56772480978225 -1 36.1643633681208 56 1082 310 8 3089 242 66 3 35 853 54 4 M11277 GO_PH_REDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PH_REDUCTION.html Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. 40/49 Gene Ontology BP GO:0045851 5.36339885116416e-08 4.02645553947883e-07 10 696.272727272727 69 4.87581725628993e-09 9 1.75565775217975 -1.65932202835342 -1 13.4756314919201 9 525 2020 1466 304 11 9 69 46 3138 62 5 M15681 GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. 122/181 Gene Ontology BP GO:0007156 3.89294609806973e-20 3.85401663708903e-18 90 441.454545454545 88 3.53904190733612e-21 13 3.18360254359386 3.21811946199021 1 66.9454621903365 39 1770 24 1232 356 13 707 87 480 88 60 6 M13305 GO_VACUOLAR_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_ACIDIFICATION.html Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. 16/18 Gene Ontology BP GO:0007035 1.30118656369816e-07 4.18739690741189e-07 25 934.454545454545 97 1.18289694605149e-08 16 1.55717098726696 -1.52542047956747 -1 11.9084422749145 24 1015 2462 1939 1337 34 16 64 97 3236 55 7 M11113 GO_FERRIC_IRON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERRIC_IRON_TRANSPORT.html The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 36/44 Gene Ontology BP GO:0015682 3.49047159758052e-08 3.99952679980378e-07 5 763 98 3.17315604814507e-09 2 1.743530526976 -1.77877018369272 -1 13.3879823850368 2 628 2573 1934 98 2 2 19 110 3002 23 8 M16469 GO_TRIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 36/44 Gene Ontology BP GO:0072512 3.49047159758052e-08 3.99952679980378e-07 5 766.454545454545 99 3.17315604814507e-09 3 1.743530526976 -1.77877018369272 -1 13.3879823850368 3 629 2574 1935 99 3 3 44 111 3006 24 9 M15608 GO_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_GUIDANCE.html The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. 211/347 Gene Ontology BP GO:0097485 3.36473159186284e-20 3.47913246598618e-18 85 412.090909090909 101 3.05884690169348e-21 23 2.60954196901578 2.89876115750675 1 54.9956905731481 82 1615 23 321 668 41 706 101 833 56 87 10 M16285 GO_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. 91/129 Gene Ontology BP GO:0001823 8.12157507166142e-12 2.50262839790997e-10 100 397.181818181818 126 7.38325006517401e-13 40 2.55959256709915 2.92972049709275 1 29.6194250404632 262 88 100 43 625 99 1687 290 1009 126 40 11 M13530 GO_PHAGOSOME_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_ACIDIFICATION.html Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. 25/30 Gene Ontology BP GO:0090383 3.02024807179349e-08 3.8051628819937e-07 30 873.545454545455 128 2.74568010296061e-09 14 1.51805583668309 -1.43247771721552 -1 11.6830448308235 26 825 2719 1926 64 32 14 128 212 3558 105 12 M16902 GO_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a synapse. 90/123 Gene Ontology BP GO:0007416 1.06273850134199e-11 3.25323832022649e-10 125 324.636363636364 139 9.66125910315561e-13 11 2.79987201343696 2.99136391845165 1 32.0238375157833 122 87 101 11 1297 54 929 335 309 187 139 13 M13107 GO_REGULATION_OF_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ORGANIZATION.html Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 124/183 Gene Ontology BP GO:0050807 1.01193397717901e-15 5.47503348350457e-14 165 469.818181818182 162 9.19939979253644e-17 42 2.90966590093572 3.0379151200237 1 46.5638926924996 162 1799 49 42 464 72 1161 65 1011 149 194 14 M11066 GO_RESPONSE_TO_PHENYLPROPANOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PHENYLPROPANOID.html Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. 10/17 Gene Ontology BP GO:0080184 1.52190606975516e-08 2.40864930019414e-07 15 495.363636363636 165 1.38355098207576e-09 6 4.97180104105677 -4.97180104105677 -1 39.6916631472695 117 1191 619 12 6 373 165 663 12 2143 148 15 M13463 GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 21/39 Gene Ontology BP GO:0086012 2.59027615714549e-09 4.87957690655787e-08 10 816.181818181818 175 2.35479650926842e-10 6 3.6954460194891 3.92722081132112 1 32.5745822792576 6 2067 175 1711 2636 24 73 6 1802 358 120 16 M16150 GO_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION.html Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. 74/127 Gene Ontology BP GO:0061337 1.11098400172887e-13 4.27223847937555e-12 75 261.181818181818 181 1.0099854561172e-14 25 3.08444515774334 3.19269338701805 1 42.3083328699765 95 169 73 354 511 25 248 356 786 181 75 17 M13165 GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. 86/157 Gene Ontology BP GO:0055007 3.55229275188597e-08 4.00785157005513e-07 280 259.727272727273 187 3.22935709931281e-09 44 2.7588687283038 2.8815359758987 1 21.2413657955881 279 127 254 44 106 170 792 150 302 446 187 18 M16895 GO_RECEPTOR_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CLUSTERING.html The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. 49/64 Gene Ontology BP GO:0043113 1.86096975994511e-07 4.80793575403919e-07 70 401.181818181818 187 1.69179083396699e-08 39 2.4217855472762 2.60143647019891 1 18.4019598361823 69 380 488 110 1718 61 123 187 848 390 39 19 M13762 GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. 25/45 Gene Ontology BP GO:0031664 9.76232329549039e-08 4.02645553947883e-07 90 387.636363636364 188 8.8748397533506e-09 22 2.60851316088933 -2.75114243600998 -1 20.0717766148925 22 773 664 88 978 44 31 321 188 1066 89 20 M12483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. 28/34 Gene Ontology BP GO:0014912 6.39255943802215e-08 4.02645553947883e-07 20 360.090909090909 194 5.8114178397921e-09 19 2.8346416897542 3.15664510089292 1 21.8206974490744 19 735 658 511 463 70 40 77 194 1167 27 21 M16122 GO_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. 131/195 Gene Ontology BP GO:0055001 2.88507089687111e-13 1.05702636875128e-11 225 396.090909090909 197 2.62279172442862e-14 21 2.83800429081082 3.12057735683048 1 37.5693963475705 223 1777 79 21 261 197 974 55 488 185 97 22 M16957 GO_DETECTION_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CALCIUM_ION.html The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. 10/20 Gene Ontology BP GO:0005513 6.3227256954083e-08 4.02645553947883e-07 25 454.727272727273 199 5.74793261556483e-09 1 3.40510445181915 3.40510445181915 1 26.2327644036893 21 1151 888 457 447 38 1 105 199 1625 70 23 M13718 GO_CARDIAC_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 139/191 Gene Ontology BP GO:0003231 1.29322986081426e-11 3.8573067579287e-10 205 600.727272727273 202 1.17566350983806e-12 41 2.55299082008606 2.86095889311261 1 28.9626458355233 202 1757 105 100 711 153 1744 913 753 129 41 24 M16833 GO_CARDIAC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. 59/93 Gene Ontology BP GO:0055006 2.01585124020828e-11 5.8259352923535e-10 205 231.818181818182 203 1.83259203656977e-12 21 3.27431305888997 3.55138258473505 1 36.4656910087964 203 289 110 30 609 159 546 75 261 247 21 25 M14347 GO_REGULATION_OF_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. 77/107 Gene Ontology BP GO:0006885 2.01340125579721e-07 4.96731497519852e-07 115 870.727272727273 205 1.83036494550924e-08 75 1.92898355260332 -1.88329399441571 -1 14.6034076803368 114 205 1467 1901 1810 75 104 154 1372 2208 168 26 M10755 GO_TRANSITION_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSPORT.html The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 87/122 Gene Ontology BP GO:0000041 4.71029443319274e-08 4.02645553947883e-07 15 1148.63636363636 206 4.28208594003832e-09 9 1.78455085060588 -1.80438336783648 -1 13.6990961827983 12 2430 2860 3143 206 9 25 125 978 2745 102 27 M16099 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 16/30 Gene Ontology BP GO:0055015 2.32488080239503e-08 3.27808193137699e-07 615 407.909090909091 215 2.11352802451229e-09 28 2.92004234621877 3.01029565715123 1 22.7965754353661 612 959 666 145 28 304 215 48 76 1227 207 28 M12499 GO_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPROUTING_ANGIOGENESIS.html The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. 69/83 Gene Ontology BP GO:0002040 1.94050334843798e-09 3.80977302965481e-08 130 620.272727272727 218 1.76409395468145e-10 65 2.76578746578555 2.82653675349136 1 24.7134599510876 130 239 167 878 2290 66 751 159 1860 218 65 29 M14538 GO_CARDIOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. 110/192 Gene Ontology BP GO:0035051 4.67001317381178e-11 1.25604458368475e-09 710 325 218 4.24546652173719e-12 25 2.82317269621432 3.10646303972407 1 30.2880435171438 707 25 119 33 124 259 1341 177 301 271 218 30 M11147 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 22/37 Gene Ontology BP GO:0055012 4.68542685121564e-08 4.02645553947883e-07 370 434.454545454545 221 4.25947904636639e-09 66 2.98671587450775 3.07667876975154 1 22.996867972059 369 853 722 180 201 221 394 66 140 1472 161 31 M11134 GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. 186/294 Gene Ontology BP GO:0051146 1.1301893777438e-13 4.31046817593597e-12 365 501.727272727273 227 1.02744488885805e-14 74 2.66391875210601 2.95214693140075 1 36.5136068941141 361 1664 74 339 108 218 1125 198 995 227 210 32 M11839 GO_AMEBOIDAL_TYPE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMEBOIDAL_TYPE_CELL_MIGRATION.html Cell migration that is accomplished by extension and retraction of a pseudopodium. 192/270 Gene Ontology BP GO:0001667 1.25277791212807e-09 2.56791877759116e-08 70 625 229 1.13888901167406e-10 15 2.35290094234769 2.47405388734302 1 21.4962780846549 66 1669 158 451 1779 15 330 229 1892 172 114 33 M10326 GO_NEURON_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_RECOGNITION.html The process in which a neuronal cell in a multicellular organism interprets its surroundings. 43/63 Gene Ontology BP GO:0008038 1.66652930066982e-08 2.58478694533889e-07 110 483.181818181818 232 1.51502664844909e-09 36 3.06715659954878 3.35404502390762 1 24.3330665480935 110 488 208 1274 1871 64 232 36 676 311 45 34 M13356 GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. 25/46 Gene Ontology BP GO:0086019 2.66925977141698e-11 7.66670723234766e-10 20 331.727272727273 232 2.4265997922267e-12 20 3.97523386271053 3.94773485387047 1 43.7205362610555 20 724 111 834 579 45 212 52 544 296 232 35 M14752 GO_MULTICELLULAR_ORGANISMAL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_SIGNALING.html The transfer of information occurring at the level of a multicellular organism. 94/189 Gene Ontology BP GO:0035637 4.19585138328662e-15 2.05508384067712e-13 195 300.909090909091 257 3.81441034844238e-16 56 3.00404574128045 3.1322547311978 1 45.9906100490103 193 72 56 335 257 118 610 451 765 135 318 36 M16618 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM.html Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. 42/56 Gene Ontology BP GO:0010880 5.13128577147298e-08 4.02645553947883e-07 35 355.636363636364 260 4.66480535559567e-09 9 2.23582142809376 2.3521665644179 1 17.1893082262928 32 472 921 543 260 35 172 124 452 892 9 37 M13149 GO_HEPATOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a hepatocyte, the main structural component of the liver. 16/17 Gene Ontology BP GO:0097284 2.63789732205295e-08 3.56806286032337e-07 530 654.454545454545 263 2.39808850334774e-09 22 2.87460035866093 -3.07051050651809 -1 22.3122300562573 526 1080 1723 183 41 611 263 22 161 2413 176 38 M12906 GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 46/75 Gene Ontology BP GO:0086065 2.44675444489421e-09 4.64683609473174e-08 30 352.181818181818 266 2.22432222510491e-10 19 3.12935840301354 3.14722208560484 1 27.6491951822242 29 411 174 842 706 19 195 257 628 347 266 39 M14729 GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. 217/287 Gene Ontology BP GO:0001763 1.44481256135977e-17 1.0504238825011e-15 270 608.545454545455 266 1.31346596487252e-18 17 2.65731545006859 2.99771724758246 1 48.0346353868681 266 1619 32 55 1171 17 1294 1272 820 87 61 40 M16251 GO_REGULATION_OF_CELLULAR_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. 67/95 Gene Ontology BP GO:0030641 1.89145352232821e-07 4.85434817396203e-07 115 860.363636363636 269 1.71950334995114e-08 73 1.85622859144989 -1.79408798050826 -1 14.0711600670232 112 269 1708 1894 1732 77 95 73 919 2431 154 41 M12305 GO_HEMIDESMOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMIDESMOSOME_ASSEMBLY.html Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. 23/25 Gene Ontology BP GO:0031581 2.05999871621459e-07 5.00792791355615e-07 15 492.272727272727 270 1.8727262810048e-08 14 3.95111260499723 4.39585269816996 1 30.0030061271021 14 798 270 830 1838 39 34 916 167 382 127 42 M15904 GO_PATTERN_SPECIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_SPECIFICATION_PROCESS.html Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. 382/609 Gene Ontology BP GO:0007389 2.54333853222295e-10 6.00403926762172e-09 355 563.727272727273 274 2.3121259386518e-11 5 2.2719118577488 2.39734858218507 1 22.4869538554785 353 1515 134 107 274 5 856 892 1800 207 58 43 M11036 GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 59/90 Gene Ontology BP GO:0051965 3.28798378268503e-09 6.02322383497379e-08 330 459.727272727273 276 2.98907617054458e-10 144 2.94189132565887 3.14050416007519 1 25.5858008642023 153 327 180 1473 210 144 761 276 1043 328 162 44 M12066 GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE.html Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. 13/16 Gene Ontology BP GO:0010889 2.17917923332154e-08 3.19914440834036e-07 260 531.090909090909 280 1.98107204991554e-09 5 2.66387539000879 -2.74885167922088 -1 20.82176955077 259 1132 1627 483 16 299 110 280 255 1376 5 45 M16018 GO_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. 253/386 Gene Ontology BP GO:0042692 8.05129772589025e-16 4.45984384744849e-14 570 509.636363636364 288 7.31936156899114e-17 23 2.51094052323898 2.82029516213599 1 40.4393842379822 568 1580 47 23 139 288 1317 172 1054 92 326 46 M15408 GO_OUTFLOW_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. 67/92 Gene Ontology BP GO:0003151 7.69975667771144e-09 1.31716793460998e-07 550 719.454545454545 289 6.99977882241795e-10 127 2.73286063037224 2.92645942368297 1 22.6374151940198 548 242 193 127 2110 289 1652 986 1337 253 177 47 M14929 GO_HEART_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_PROCESS.html A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 101/167 Gene Ontology BP GO:0003015 7.24323357232872e-11 1.87555327651606e-09 680 517.545454545455 293 6.5847577932429e-12 55 2.74292287639586 3.05515142136784 1 28.8465472196076 676 55 123 355 272 495 2474 289 421 293 240 48 M11226 GO_MORPHOGENESIS_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIUM.html The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. 472/611 Gene Ontology BP GO:0002009 1.5114951184116e-24 2.81319471438768e-22 720 684.636363636364 306 1.37408647128327e-25 11 2.46454955404326 2.68522879498523 1 64.1317814175433 716 1450 11 306 253 67 1971 1648 875 45 189 49 M12997 GO_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_MORPHOGENESIS.html The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 271/374 Gene Ontology BP GO:0003007 2.55606366915909e-14 1.10123743079604e-12 310 705.090909090909 307 2.3236942446901e-15 36 2.44245637837038 2.73244171046582 1 35.2201330334403 307 1572 65 446 1655 73 1730 245 1479 148 36 50 M14876 GO_UROGENITAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UROGENITAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. 343/437 Gene Ontology BP GO:0001655 1.61693766328211e-26 6.26967578937638e-24 305 603.636363636364 308 1.46994333025646e-27 4 2.55327026121488 2.80378688559581 1 71.5452529611092 303 1518 4 308 729 16 1331 1230 927 41 233 51 M14476 GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a cardiac muscle cell. 41/74 Gene Ontology BP GO:0086001 7.54673003265523e-15 3.4426406707789e-13 65 373.727272727273 310 6.86066366605023e-16 61 3.55965052595612 3.66167207292267 1 53.5511208351785 140 431 61 320 1321 63 566 310 589 217 93 52 M16429 GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. 170/262 Gene Ontology BP GO:0098742 1.10170903692325e-29 1.02525042976078e-26 40 545.636363636364 312 1.00155366993024e-30 1 3.09834781238468 3.08717289249684 1 97.2819347274764 324 1657 1 1038 285 36 1056 312 994 37 262 53 M14617 GO_IRON_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_IMPORT.html The directed movement of iron ions into a cell or organelle. 12/16 Gene Ontology BP GO:0097286 2.19668338414461e-06 2.92870137146845e-06 255 1192 323 1.99698688865404e-07 42 2.8066066103159 -3.05842496215233 -1 18.6788211871312 255 2255 1760 1942 3491 323 83 131 42 2574 256 54 M12854 GO_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 75/117 Gene Ontology BP GO:0051963 2.07647884425024e-12 7.00471966859823e-11 225 496 326 1.88770804022927e-13 87 3.08177365674172 3.2447890501066 1 37.7441732727712 326 201 87 1046 476 277 1336 224 844 223 416 55 M11566 GO_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_MOVEMENT.html Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. 97/158 Gene Ontology BP GO:0030048 1.60877093228838e-11 4.70793153958353e-10 1245 946 329 1.46251902936376e-12 10 2.86906495986283 3.14246526007556 1 32.2608249490982 1241 65 108 10 312 2008 3811 701 329 305 1516 56 M13694 GO_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. 35/60 Gene Ontology BP GO:0086003 1.43111853266625e-11 4.24139779139875e-10 565 443.363636363636 331 1.30101684788687e-12 106 3.32109630160563 3.39509362244373 1 37.5418869638435 561 506 106 331 132 352 1910 340 258 240 141 57 M16898 GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS.html A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. 52/66 Gene Ontology BP GO:0061640 8.59673946351314e-08 4.02645553947883e-07 695 555.545454545455 332 7.81521799949102e-09 53 2.14940594030029 2.34031187920351 1 16.5209544906688 694 358 1274 53 833 302 321 332 87 1762 95 58 M10833 GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. 24/34 Gene Ontology BP GO:0031290 6.64755749639058e-08 4.02645553947883e-07 75 480.727272727273 337 6.04323427023121e-09 13 3.03826262881522 3.32990866597712 1 23.3955403244391 74 824 594 526 1487 108 94 13 337 1185 46 59 M11503 GO_KIDNEY_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 142/192 Gene Ontology BP GO:0072073 6.31461627040909e-17 4.1382971135512e-15 385 561.545454545455 339 5.74056024582642e-18 27 2.52316351198012 2.89163940992456 1 43.7874150853055 381 1726 39 27 215 163 1823 799 623 42 339 60 M10516 GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. 52/70 Gene Ontology BP GO:0055024 5.88485591983892e-08 4.02645553947883e-07 340 392.909090909091 340 5.34986916114089e-09 146 2.67715555228497 2.79938868855831 1 20.6026698596438 340 354 336 206 391 146 299 680 225 842 503 61 M15117 GO_EPITHELIAL_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MORPHOGENESIS.html The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. 53/69 Gene Ontology BP GO:0003382 3.81597170064899e-08 4.02645553947883e-07 1735 806.818181818182 341 3.46906524258024e-09 29 2.51829641936721 -2.66740362607766 -1 19.3740232635923 1735 322 295 29 127 1931 2572 654 341 171 698 62 M14063 GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of smoothened signaling. 64/92 Gene Ontology BP GO:0008589 1.14002811630703e-07 4.06950048332718e-07 315 894 343 1.03638925034788e-08 80 2.19813431185644 2.0578937409349 1 16.8855518418463 314 343 1668 1971 1185 80 231 295 1731 1742 274 63 M14533 GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 498/622 Gene Ontology BP GO:0010975 3.53049094654533e-18 2.83230592659921e-16 620 589.636363636364 343 3.20953722413212e-19 30 2.31085586920194 2.54802696156088 1 43.3493138114117 619 1429 30 325 335 95 1403 675 1156 76 343 64 M11126 GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. 13/20 Gene Ontology BP GO:2000311 4.81600092255594e-07 8.61718760667532e-07 55 781.454545454545 347 4.3781836152935e-08 10 3.63544306345863 3.78221289679541 1 26.5613912518006 53 1100 347 1730 2551 84 10 108 1819 501 293 65 M13192 GO_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE.html Any process that modulates the frequency or rate of heart contraction. 104/161 Gene Ontology BP GO:0002027 8.48186485785185e-17 5.40631742240885e-15 425 466.090909090909 347 7.71078623441076e-18 38 3.08480221609074 3.21415150878828 1 53.1240426161875 422 41 38 347 365 117 1259 1262 1026 167 83 66 M12932 GO_TISSUE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MIGRATION.html The process in which the population of cells that make up a tissue undergo directed movement. 125/181 Gene Ontology BP GO:0090130 4.10658708840975e-07 7.7360120333484e-07 350 661.545454545455 350 3.73326168632546e-08 21 2.42079338600905 2.69129642630548 1 17.789637220898 160 21 350 890 2420 28 349 501 1791 673 94 67 M14927 GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. 104/168 Gene Ontology BP GO:0055067 9.44971472431829e-08 4.02645553947883e-07 320 548.818181818182 350 8.59065011837662e-09 57 2.28477990674809 -2.1621218137554 -1 17.5679623649733 319 57 425 1693 939 203 311 212 690 838 350 68 M16725 GO_NEGATIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a lower concentration of a chemical. 56/67 Gene Ontology BP GO:0050919 1.36396156735826e-07 4.23928240920297e-07 25 452.818181818182 353 1.23996513811046e-08 21 2.58724615653928 2.88395439892217 1 19.8372994046343 47 353 382 537 1396 21 181 24 1560 428 52 69 M11606 GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 493/649 Gene Ontology BP GO:0051962 1.7358308444843e-18 1.50304178270623e-16 660 629.727272727273 355 1.57802804044026e-19 27 2.30669959828528 2.52516975256464 1 44.03880496529 656 1437 27 340 355 130 1728 669 1262 60 263 70 M11914 GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. 51/66 Gene Ontology BP GO:0016339 7.70302592763236e-08 4.02645553947883e-07 50 489.454545454545 356 7.00275108849474e-09 18 2.76836281596555 2.99436803399208 1 21.3080840967613 49 376 321 1696 685 18 356 119 1255 478 31 71 M10170 GO_HINDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). 160/247 Gene Ontology BP GO:0030902 2.05221052737692e-07 5.00119458251237e-07 175 742.454545454545 357 1.86564610801078e-08 74 2.22557273641986 2.41500718747402 1 16.8566263284481 171 1741 620 179 1830 74 324 357 1511 1262 98 72 M13993 GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. 171/268 Gene Ontology BP GO:0048738 5.37344376555564e-15 2.47550830110202e-13 85 468.272727272727 357 4.88494887777787e-16 60 2.68521347830759 2.8486250865194 1 40.8359915884881 84 1692 60 357 678 68 790 542 663 131 86 73 M14116 GO_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_MIGRATION.html The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. 45/59 Gene Ontology BP GO:0008347 5.71386311795419e-08 4.02645553947883e-07 240 410.818181818182 357 5.19442115123204e-09 16 2.43041483813112 2.61756883202609 1 18.6943304838436 239 468 754 546 357 139 630 70 170 1130 16 74 M12378 GO_PALATE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALATE_DEVELOPMENT.html The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. 118/155 Gene Ontology BP GO:0060021 1.98292321616509e-07 4.93246485651519e-07 20 641 359 1.80265763171971e-08 16 2.44759840568027 2.73898701909766 1 18.56632332632 16 37 273 1388 1791 26 359 482 2073 533 73 75 M13648 GO_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 563/777 Gene Ontology BP GO:0007507 1.15420114865065e-10 2.8873644863825e-09 230 913.909090909091 364 1.15420114871059e-11 37 2.31094256773776 2.64236193982759 1 23.7636404793244 228 1416 4440 364 709 37 1241 268 1191 106 53 76 M14073 GO_ACTIN_MEDIATED_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MEDIATED_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. 79/134 Gene Ontology BP GO:0070252 5.62795461922396e-13 2.01437483409608e-11 570 509.636363636364 366 5.11632238111399e-14 16 3.0074924808185 3.23334289306742 1 38.8005944410163 570 130 81 16 273 714 2254 366 385 224 593 77 M10048 GO_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. 90/162 Gene Ontology BP GO:0021510 9.35950184933544e-08 4.02645553947883e-07 130 454.545454545455 367 8.50863840683502e-09 25 2.29758319180422 2.37748427977595 1 17.6669853944558 127 126 553 711 924 65 367 139 1224 739 25 78 M11847 GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 100/124 Gene Ontology BP GO:0006023 5.64377234762508e-09 9.94714876268921e-08 55 810.454545454545 367 5.13070214736669e-10 52 2.48486703036949 2.57358649660519 1 20.9402993824195 52 92 188 2635 1238 266 695 367 2422 229 731 79 M13301 GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 19/33 Gene Ontology BP GO:0010644 3.39209881197299e-08 3.99952679980378e-07 90 401 367 3.08372624024956e-09 86 2.71519537468164 2.44864531110985 1 20.9064468666079 103 862 473 367 86 135 106 843 89 622 725 80 M11727 GO_SPECIFICATION_OF_ORGAN_IDENTITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_ORGAN_IDENTITY.html The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. 13/21 Gene Ontology BP GO:0010092 3.12698948146517e-07 6.42946622061751e-07 280 1059.63636363636 375 2.84271811447516e-08 45 2.31262718058824 2.53515270251031 1 17.2148659161613 278 1144 2077 1026 3171 306 191 45 264 2779 375 81 M11359 GO_ARTERY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_DEVELOPMENT.html The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. 119/156 Gene Ontology BP GO:0060840 7.25552524764433e-11 1.87555327651606e-09 125 814.181818181818 378 6.59593204353057e-12 14 2.71498413820425 3.12638634237952 1 28.551674677452 280 14 124 124 3032 531 2416 1043 782 232 378 82 M12009 GO_DECIDUALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DECIDUALIZATION.html The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. 20/25 Gene Ontology BP GO:0046697 3.39809933204117e-08 3.99952679980378e-07 220 1076.54545454545 381 3.08918125866171e-09 87 2.68472352714677 -2.91097211439431 -1 20.6706644320372 217 3292 1790 1960 87 437 158 102 381 3057 361 83 M10365 GO_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_TISSUE_DEVELOPMENT.html The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. 290/442 Gene Ontology BP GO:0060537 1.04678563400402e-16 6.49425807336096e-15 285 561.272727272727 383 9.5162330364002e-18 40 2.49077508541252 2.71641929943457 1 42.6344811020829 283 1550 40 383 770 50 1246 584 1119 81 68 84 M10162 GO_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCRETION.html The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. 34/63 Gene Ontology BP GO:0007588 5.38662117968932e-08 4.02645553947883e-07 945 479.454545454545 386 4.89692846507164e-09 88 3.36650773802656 -3.13250762423378 -1 25.9342501152815 943 561 232 292 310 948 508 237 88 769 386 85 M11608 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. 35/45 Gene Ontology BP GO:0060043 5.88179129002423e-08 4.02645553947883e-07 390 353.363636363636 386 5.3470831338876e-09 50 2.89977488281658 3.13046831844607 1 22.3244498898453 690 517 243 163 390 215 386 557 118 558 50 86 M11807 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. 36/47 Gene Ontology BP GO:0010881 8.8410437946386e-08 4.02645553947883e-07 15 414.909090909091 390 8.03731286357251e-09 6 2.29901012938858 2.38478499275487 1 17.678021599763 11 553 956 547 859 14 70 46 390 1112 6 87 M11803 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE.html Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. 72/118 Gene Ontology BP GO:0050885 1.0379191698194e-07 4.02645553947883e-07 600 642.090909090909 392 9.43562926169545e-09 71 2.47208201573461 2.56824041926927 1 19.0165923204112 597 210 317 71 1058 392 1165 1687 1055 299 212 88 M16803 GO_NEUROPEPTIDE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. 30/105 Gene Ontology BP GO:0007218 2.85335571509754e-07 6.02389480142871e-07 170 613 392 2.59396007742918e-08 167 3.89150191510061 4.13640983942574 1 29.1712535929072 167 743 272 392 2144 347 376 244 479 608 971 89 M13435 GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response. 13/29 Gene Ontology BP GO:0002739 1.69573687896096e-07 4.57141581564622e-07 250 710.454545454545 395 1.5415790996969e-08 149 2.78838446481555 -3.22851368731166 -1 21.2770297180064 250 1135 1284 149 1643 395 444 306 168 1812 229 90 M10188 GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 29/42 Gene Ontology BP GO:0052646 5.95293388188046e-08 4.02645553947883e-07 55 1225.90909090909 397 5.4117582208724e-09 29 1.98344908450715 -2.22441179694278 -1 15.2374127627456 55 3243 1947 2361 397 69 84 29 2540 2501 259 91 M12757 GO_PHAGOSOME_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_MATURATION.html A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. 41/49 Gene Ontology BP GO:0090382 5.56068343839517e-08 4.02645553947883e-07 380 1249.81818181818 398 5.05516688995097e-09 127 1.36439809269604 -1.37315100644233 -1 10.4495552445709 376 557 3020 3377 342 127 201 398 1493 3627 230 92 M15056 GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. 69/101 Gene Ontology BP GO:0042475 5.96999523113287e-08 4.02645553947883e-07 400 404.272727272727 399 5.42726853921518e-09 103 3.09632468710986 3.05659294088438 1 23.844603270794 181 255 246 453 399 103 336 670 400 809 595 93 M16337 GO_AXONAL_FASCICULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_FASCICULATION.html The collection of axons into a bundle of rods, known as a fascicle. 31/43 Gene Ontology BP GO:0007413 1.17352854091941e-07 4.08625383150012e-07 75 505.090909090909 401 1.06684418501637e-08 17 2.85016286367728 3.29493990927703 1 21.9186720912023 72 666 401 917 1944 106 197 17 711 433 92 94 M15217 GO_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. 395/509 Gene Ontology BP GO:0035239 2.36202583116403e-16 1.39120331549446e-14 410 617.636363636364 408 2.14729621014912e-17 10 2.34109666714745 2.5151145744216 1 39.1294832906354 408 1493 43 36 459 10 1762 1444 943 64 132 95 M15958 GO_TELENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. 288/430 Gene Ontology BP GO:0021537 3.48472159263936e-11 9.70922728775505e-10 170 705.636363636364 410 3.16792872063142e-12 55 2.329352028967 2.5663316663018 1 25.2871538012316 169 1567 114 564 1722 55 1311 135 1573 410 142 96 M12792 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. 45/56 Gene Ontology BP GO:0010882 7.26718039116769e-08 4.02645553947883e-07 65 434.545454545455 413 6.60652784656532e-09 7 2.1997890269648 2.2299396500285 1 16.9106268172889 63 441 981 538 611 43 221 333 413 1129 7 97 M14191 GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 183/238 Gene Ontology BP GO:0031345 3.82406231232121e-08 4.02645553947883e-07 830 688.727272727273 413 3.47642034435587e-09 128 2.2600024506858 2.49813908321874 1 17.3763288309699 829 1673 287 413 128 202 1112 1122 1139 335 336 98 M15044 GO_RESPONSE_TO_THYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_THYROID_HORMONE.html A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 29/42 Gene Ontology BP GO:0097066 4.19026241018817e-08 4.02645553947883e-07 210 751.363636363636 413 3.80932953636238e-09 118 2.36056457228551 -2.58366087992797 -1 18.1540953095215 208 752 1811 1311 155 413 118 165 219 2504 609 99 M13349 GO_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFIBRIL_ASSEMBLY.html Formation of myofibrils, the repeating units of striated muscle. 48/82 Gene Ontology BP GO:0030239 6.29695969329590e-09 1.09736904317999e-07 725 631 417 5.72450882847217e-10 50 3.41059892118756 3.74787358351311 1 28.6039814951454 721 417 190 345 960 1182 1885 50 412 514 265 100 M11649 GO_TONGUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TONGUE_DEVELOPMENT.html The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. 15/29 Gene Ontology BP GO:0043586 2.00055066289853e-08 3.00276201111835e-07 355 1288.45454545455 418 1.81868243735488e-09 7 2.413908685019 2.59445799976762 1 18.9386029393766 354 2204 1744 2700 3527 394 390 7 418 2229 206 101 M13171 GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS.html The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. 48/73 Gene Ontology BP GO:0001658 1.42926061459646e-07 4.2854237685504e-07 445 611.090909090909 419 1.29932791586397e-08 123 2.64191404626501 3.00740405007268 1 20.2436106138017 445 419 380 123 1451 298 1243 817 1002 351 193 102 M14420 GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION.html A cardiac conduction process that modulates the frequency or rate of heart contraction. 37/62 Gene Ontology BP GO:0086091 9.16373355745475e-09 1.53930874522877e-07 250 447.181818181818 421 8.33066690511341e-10 86 3.33261189832611 3.5862916427564 1 27.3551986188155 248 532 196 850 620 190 581 86 827 368 421 103 M16051 GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE.html The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. 191/250 Gene Ontology BP GO:0048754 1.09421956194702e-16 6.69921529176247e-15 165 640.818181818182 421 9.94745056315466e-18 27 2.68829322122346 2.98645325201628 1 45.979681205963 165 1654 41 421 1439 27 1160 1177 781 84 100 104 M14400 GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein homooligomerization. 18/19 Gene Ontology BP GO:0032462 1.00061888073025e-07 4.02645553947883e-07 75 946.636363636364 423 9.09653569310074e-09 71 3.54885809319278 -3.56849457124617 -1 27.3445822696169 267 3313 1426 102 1004 474 71 106 73 3154 423 105 M10163 GO_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 97/235 Gene Ontology BP GO:0007586 4.56036899632163e-15 2.18756669483346e-13 470 441.909090909091 425 4.14578999665601e-16 58 3.29697758440018 -3.19171808426917 -1 50.3771225403903 469 94 58 312 236 690 425 771 610 304 892 106 M10347 GO_METENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. 120/189 Gene Ontology BP GO:0022037 3.58051358615808e-07 7.01774630008152e-07 365 667.636363636364 426 3.25501288080819e-08 35 2.44115708728643 2.72725965403948 1 18.0650906384895 364 44 626 160 2318 132 426 547 898 1794 35 107 M16855 GO_STEROID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 20/65 Gene Ontology BP GO:0006706 6.15866916797665e-08 4.02645553947883e-07 245 615.636363636364 427 5.59879030943832e-09 59 3.00212664802634 -3.01472813932476 -1 23.1160578107442 242 925 876 1479 427 152 260 90 761 1501 59 108 M15342 GO_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_GROWTH.html Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 53/75 Gene Ontology BP GO:0060420 4.97569623649187e-08 4.02645553947883e-07 105 632.090909090909 429 4.52336031729655e-09 101 2.68450128264858 2.81341441539213 1 20.6594831283618 1211 336 291 105 246 429 775 1598 101 903 958 109 M16906 GO_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS.html The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. 123/161 Gene Ontology BP GO:0042476 1.75305041673847e-18 1.50304178270623e-16 775 550.090909090909 430 1.59368219703497e-19 28 3.22012849876664 3.12703159541672 1 61.5184810606628 92 1798 28 330 773 138 986 775 495 206 430 110 M10925 GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of neuron differentiation. 374/480 Gene Ontology BP GO:0045666 4.90261609972333e-11 1.31102716735705e-09 705 678.636363636364 435 4.45692372712055e-12 90 2.27283904124355 2.49531288230901 1 24.3126446999369 705 1508 120 405 435 90 1763 854 1202 193 190 111 M12477 GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 96/128 Gene Ontology BP GO:0071300 3.11626823664834e-07 6.41876764281749e-07 370 1040.72727272727 435 2.83297152551211e-08 133 2.84068534884419 2.95534373803811 1 21.1716492369227 368 133 306 812 2200 435 2126 2347 1957 427 337 112 M12187 GO_DIGESTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 176/259 Gene Ontology BP GO:0055123 4.41756294113513e-12 1.38884597061498e-10 440 755.454545454545 436 4.01596631013091e-13 94 2.30089405850038 2.46300276976107 1 27.3270309606726 436 1675 97 140 664 123 1604 2186 1112 94 179 113 M10863 GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL.html The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 28/53 Gene Ontology BP GO:0086010 2.10892799165989e-08 3.11518791910904e-07 105 702.090909090909 439 1.91720728352378e-09 8 3.38293016993371 3.99248713884597 1 26.5171940456132 105 704 215 1716 1796 166 439 8 1875 480 219 114 M14841 GO_MUSCLE_FIBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FIBER_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. 47/79 Gene Ontology BP GO:0048747 4.83991088584959e-07 8.64495406981118e-07 260 724.818181818182 439 4.39991995510064e-08 22 2.67574236979987 3.27880077328774 1 19.5178946533544 256 475 742 887 2558 184 313 88 439 2009 22 115 M11392 GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE.html A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. 22/27 Gene Ontology BP GO:0035584 6.22744800732397e-08 4.02645553947883e-07 140 814.909090909091 440 5.66131653054703e-09 78 2.61070587985673 2.70912227606452 1 20.0887355183305 136 885 1027 1338 440 278 255 78 3130 1197 200 116 M13082 GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. 6/22 Gene Ontology BP GO:0010896 4.27964177878179e-08 4.02645553947883e-07 360 1014.27272727273 442 4.27964186120078e-09 47 3.45814058089314 -3.45814058089314 -1 26.6429558623588 357 1283 4406 1293 205 600 442 148 47 2247 129 117 M15223 GO_SENSORY_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. 498/760 Gene Ontology BP GO:0007423 8.89179127422953e-22 1.12660038432728e-19 765 680.909090909091 444 8.0834466129359e-23 17 2.34832299334334 2.61952518292105 1 53.7110689624173 765 1434 17 313 569 87 2675 444 1063 79 44 118 M13090 GO_CARDIAC_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_MORPHOGENESIS.html The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 84/124 Gene Ontology BP GO:0003208 1.11055734411108e-11 3.37740086414958e-10 415 826.727272727273 445 1.00959758556062e-12 102 2.76582706336144 3.00062291085018 1 31.5787808700067 411 120 102 445 2086 780 2723 1267 614 146 400 119 M14840 GO_STRIATED_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_PROLIFERATION.html The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. 24/29 Gene Ontology BP GO:0014855 5.76826492024626e-08 4.02645553947883e-07 930 564.090909090909 445 5.24387733771512e-09 66 2.62780775254602 2.79079287119627 1 20.2210046380208 926 762 638 433 370 1002 895 417 251 445 66 120 M11697 GO_ORGAN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. 38/46 Gene Ontology BP GO:0048799 6.08018585973328e-08 4.02645553947883e-07 350 743.272727272727 446 5.52744184342968e-09 76 2.82048662878012 2.99159060314325 1 21.7112195288361 350 544 446 109 414 294 823 2382 1642 1096 76 121 M16206 GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels. 880/1179 Gene Ontology BP GO:0072358 5.05344403787416e-18 3.85470083741451e-16 450 1043.45454545455 446 5.05344403787419e-19 34 2.34130440424321 2.54528577575993 1 43.542847318716 446 1365 4603 318 561 136 1552 445 1739 34 279 122 M14502 GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. 27/30 Gene Ontology BP GO:0098927 4.92655930746522e-08 4.02645553947883e-07 205 1818.36363636364 447 4.47869037980717e-09 86 0.906964689794237 -0.996609326278172 -1 6.91167874308894 205 2588 3897 4340 239 86 117 447 3879 3908 296 123 M15697 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction. 84/122 Gene Ontology BP GO:0055117 4.06549890952329e-08 4.02645553947883e-07 660 622.636363636364 450 3.69590816786531e-09 129 2.48652871007818 2.40814190109651 1 19.128325788317 660 129 369 450 142 263 1798 878 813 394 953 124 M15544 GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH.html Any process that modulates the extent of cell growth. 126/153 Gene Ontology BP GO:0061387 3.79483172260553e-08 4.02645553947883e-07 665 690.090909090909 452 3.44984708005772e-09 1 2.38822383382028 2.71561846585786 1 18.3680172723939 662 1 379 893 123 615 2529 303 1311 452 323 125 M11421 GO_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXON_GUIDANCE.html Any process that modulates the frequency, rate or extent of axon guidance. 37/47 Gene Ontology BP GO:1902667 3.51875239833504e-07 6.95537638350604e-07 60 733.818181818182 453 3.19886632830546e-08 58 2.72676924154163 2.81518384681086 1 20.2035137619732 58 571 443 1276 2296 179 134 74 1973 453 615 126 M13089 GO_RENAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_TUBULE_DEVELOPMENT.html The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. 104/137 Gene Ontology BP GO:0061326 5.10366812252117e-14 2.08310243632377e-12 345 792.363636363636 453 4.63969829320115e-15 47 2.71751288175901 3.104883832762 1 38.2882171534608 342 47 69 80 2116 470 2511 1365 1178 85 453 127 M16602 GO_NEURAL_CREST_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. 82/108 Gene Ontology BP GO:0014033 3.00714999879656e-10 6.99613447220019e-09 155 780.454545454545 454 2.73377272655236e-11 136 2.75135120687115 2.80787693318251 1 27.0330878109412 154 166 136 1282 2463 327 454 475 1763 163 1202 128 M16634 GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 320/389 Gene Ontology BP GO:0010976 1.34907864371901e-08 2.17206329730954e-07 655 668.272727272727 454 1.22643513817437e-09 133 2.25993487987974 2.53959071237543 1 18.1084307364995 651 1539 204 454 321 133 1669 521 1215 397 247 129 M11940 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. 103/126 Gene Ontology BP GO:0048640 1.50803205609799e-07 4.37436111265502e-07 460 480.727272727273 456 1.37093832678994e-08 81 2.61628842630215 3.01493967446614 1 20.0180294131206 456 81 307 479 1509 114 673 419 577 489 184 130 M13393 GO_MUSCLE_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_MORPHOGENESIS.html The process in which the anatomical structures of muscle are generated and organized. 82/133 Gene Ontology BP GO:0048644 2.73430846243183e-10 6.39333531441975e-09 410 749.545454545455 456 2.48573496615605e-11 135 2.87079756925539 3.04265621137068 1 28.3470233415552 406 156 135 463 1283 456 2882 1180 839 265 180 131 M14185 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 111/165 Gene Ontology BP GO:0002065 3.55736664180694e-08 4.00785157005513e-07 3510 1611.45454545455 458 3.23396972666275e-09 26 2.49285562642096 -2.21355705710151 -1 19.1833230664026 3510 26 223 49 286 3994 2952 3938 458 372 1918 132 M16556 GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/22 Gene Ontology BP GO:0051957 4.68681004312897e-08 4.02645553947883e-07 345 577.181818181818 460 4.26073649361389e-09 2 3.26630785737584 3.08383318625257 1 25.1592852767789 343 1137 1004 501 202 485 460 56 66 2093 2 133 M10039 GO_CARDIAC_CHAMBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_DEVELOPMENT.html The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. 193/257 Gene Ontology BP GO:0003205 4.06883228274984e-12 1.28790997358061e-10 465 653 461 3.69893843887034e-13 10 2.4461796226432 2.81622438680219 1 29.1559879118838 207 1655 96 464 1236 78 2013 461 860 103 10 134 M11764 GO_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. 109/145 Gene Ontology BP GO:0019722 1.80695254189889e-08 2.76158154529189e-07 815 942.636363636364 462 1.64268414249105e-09 32 2.49873812234908 2.46290537536796 1 19.7176482681271 812 32 211 423 1336 227 1782 2450 2218 416 462 135 M15276 GO_SENSORY_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_MORPHOGENESIS.html Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 265/407 Gene Ontology BP GO:0090596 1.85431523657835e-15 9.80469181340802e-14 625 824.818181818182 464 1.68574112416214e-16 50 2.45051678467529 2.73180685634684 1 38.4498592879933 625 1575 50 389 1453 393 2830 464 1037 169 88 136 M15744 GO_NEUROMUSCULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS.html Any process pertaining to the functions of the nervous and muscular systems of an organism. 107/199 Gene Ontology BP GO:0050905 3.60207202054143e-08 4.02645553947883e-07 670 649.909090909091 465 3.27461098138032e-09 51 2.43245551691795 2.59356134218843 1 18.7101134797534 670 51 224 419 928 465 1949 832 1027 242 342 137 M16960 GO_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. 174/259 Gene Ontology BP GO:0048592 1.68893049373181e-12 5.82118043506232e-11 445 905.090909090909 466 1.53539135793919e-13 85 2.55895765861391 2.96101090119151 1 31.5722510749936 443 1702 85 466 1817 665 2625 442 1103 274 334 138 M11037 GO_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMISSION_OF_NERVE_IMPULSE.html The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. 42/102 Gene Ontology BP GO:0019226 2.01877474687217e-08 3.02037263575441e-07 215 534.636363636364 467 1.8352497867245e-09 161 3.01554057881854 3.10007228158166 1 23.6751751402608 386 467 213 682 161 486 1240 215 1086 277 668 139 M15083 GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 49/59 Gene Ontology BP GO:0051784 4.68987284473238e-08 4.02645553947883e-07 100 1105.18181818182 467 4.26352085882658e-09 96 1.79761043788154 1.80452119621816 1 13.8001015021486 197 2490 2537 2463 203 100 96 220 678 2706 467 140 M15038 GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. 46/69 Gene Ontology BP GO:0048483 1.39038365537227e-07 4.2534221883282e-07 365 668.909090909091 471 1.26398522113045e-08 228 2.63114864964097 2.99475521306501 1 20.1710600978099 363 471 479 586 1418 228 1228 362 1446 422 355 141 M11811 GO_FOREBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 391/610 Gene Ontology BP GO:0030900 1.42171367503658e-10 3.49470657007754e-09 1515 839.363636363636 473 1.29246697738951e-11 131 2.23129173845465 2.52072252997308 1 22.7173031192334 388 1512 131 562 1511 311 2052 473 1658 374 261 142 M15599 GO_KIDNEY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MORPHOGENESIS.html Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 84/117 Gene Ontology BP GO:0060993 1.14554250437962e-09 2.35849967826477e-08 130 620.454545454545 475 1.04140227725101e-10 75 2.52261939279179 2.84441749080039 1 23.1669800163935 475 128 209 75 555 255 1709 1394 1328 130 567 143 M15968 GO_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. 124/190 Gene Ontology BP GO:0048593 6.37246297063662e-08 4.02645553947883e-07 770 749.363636363636 475 5.79314832292702e-09 146 2.40439486400255 2.75284357691553 1 18.4930870799849 770 1809 260 475 460 371 2133 327 915 577 146 144 M10610 GO_NEGATIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. 67/78 Gene Ontology BP GO:0051782 2.95007038598289e-08 3.74023910244642e-07 435 733.636363636364 479 2.68188220503782e-09 62 1.9745594903247 2.01636954540188 1 15.2451320412405 431 308 1793 1534 62 97 211 479 546 2011 598 145 M10631 GO_CARDIAC_CHAMBER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_MORPHOGENESIS.html The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. 133/183 Gene Ontology BP GO:0003206 3.47493138500143e-11 9.70922728775505e-10 415 845.181818181818 480 3.15902853186938e-12 84 2.54838784952367 2.77407866709957 1 27.6746606526158 413 1781 113 480 1582 224 2462 1115 941 102 84 146 M10110 GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS.html The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 1008/1359 Gene Ontology BP GO:0048646 8.14159402003909e-21 9.23971633542485e-19 495 983.454545454545 484 8.14159402003911e-22 21 2.2835093838152 2.42673935597667 1 49.701944942472 492 1339 4224 297 235 185 1211 416 1914 21 484 147 M12205 GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE.html Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. 32/38 Gene Ontology BP GO:1902668 1.59424479041768e-07 4.451187824325e-07 65 752.636363636364 488 1.44931355085974e-08 23 2.72557371420644 2.91757908757381 1 20.8335812216928 65 665 559 889 2526 172 186 23 2223 488 483 148 M11397 GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 46/67 Gene Ontology BP GO:0009187 6.27588661871673e-08 4.02645553947883e-07 425 883.363636363636 490 5.70535163431585e-09 299 2.50037719661813 2.4954961557319 1 19.2354326038665 299 460 490 1697 444 421 829 2476 1216 421 964 149 M11013 GO_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of a tissue are generated and organized. 599/815 Gene Ontology BP GO:0048729 3.55645863823698e-20 3.59743522689493e-18 500 955.818181818182 496 3.55645863823699e-21 23 2.44728503467227 2.65006980605915 1 51.5267678104763 496 1405 4274 290 271 81 1861 700 917 23 196 150 M12159 GO_MOTOR_NEURON_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_NEURON_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. 42/55 Gene Ontology BP GO:0008045 1.60951687270512e-07 4.4655132638076e-07 575 554.454545454545 496 1.46319726405196e-08 90 2.69512174374539 3.13295932807502 1 20.5951154378873 575 496 345 583 1589 213 526 133 1136 413 90 151 M16566 GO_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_WALKING_BEHAVIOR.html The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 43/79 Gene Ontology BP GO:0090659 1.28256383869978e-07 4.17034908558357e-07 320 709.181818181818 496 1.16596719406468e-08 71 2.74968709568929 3.28682285808711 1 21.1129308685054 318 480 605 496 1323 568 1913 490 71 1328 209 152 M11021 GO_ADULT_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_WALKING_BEHAVIOR.html The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 43/79 Gene Ontology BP GO:0007628 1.28256383869978e-07 4.17034908558357e-07 1325 708.818181818182 499 1.16596719406468e-08 70 2.74968709568929 3.28682285808711 1 21.1129308685054 317 479 604 495 1322 567 1912 499 70 1324 208 153 M12572 GO_MUSCLE_STRUCTURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_STRUCTURE_DEVELOPMENT.html The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. 452/653 Gene Ontology BP GO:0061061 1.88244668056815e-20 2.03698241969386e-18 650 688.454545454545 499 1.71131516415286e-21 22 2.4223570478931 2.6809417686183 1 51.7244946338584 646 1463 22 326 499 147 2012 688 1400 30 340 154 M13433 GO_MESONEPHRIC_TUBULE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHRIC_TUBULE_MORPHOGENESIS.html The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. 57/83 Gene Ontology BP GO:0072171 3.92224584949004e-08 4.02645553947883e-07 735 729.363636363636 499 3.56567810856124e-09 84 2.69225433430689 3.07920146913274 1 20.7194466970533 732 321 227 84 697 499 2375 1378 1087 209 414 155 M14932 GO_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_DEVELOPMENT.html The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. 188/268 Gene Ontology BP GO:0060485 2.12720862478191e-17 1.47952073398696e-15 455 729.545454545455 499 1.93382602252901e-18 34 2.56008530133985 2.76567911882791 1 45.8127255140592 453 1653 34 375 1339 160 1098 962 1370 82 499 156 M14206 GO_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTION_POTENTIAL.html A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. 71/148 Gene Ontology BP GO:0001508 9.19619935674848e-14 3.59579122747485e-12 1085 614.181818181818 501 8.36018123340802e-15 17 3.15156764645625 3.45698835781489 1 43.516603372333 1083 170 71 17 501 581 2577 647 616 192 301 157 M13421 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. 179/302 Gene Ontology BP GO:0021953 2.12937301676938e-12 7.12803787555967e-11 770 837.090909090909 502 1.9357936516104e-13 89 2.59775910797433 2.78936154113622 1 31.7761993359546 768 1694 89 144 1220 469 2161 502 1612 204 345 158 M12840 GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to another neuron across a synapse. 50/105 Gene Ontology BP GO:0007270 5.77200368833455e-08 4.02645553947883e-07 2145 1264.27272727273 507 5.24727621797367e-09 260 2.72312553021991 3.27514004750878 1 20.9582103682249 2143 368 351 380 371 1850 3432 3207 260 507 1038 159 M14224 GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. 70/74 Gene Ontology BP GO:0007044 9.0913514715203e-08 4.02645553947883e-07 335 708.272727272727 507 8.26486531564934e-09 166 2.76020047400858 3.22852700047833 1 21.2449549994469 332 258 507 1244 893 532 2143 432 417 867 166 160 M15828 GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. 161/235 Gene Ontology BP GO:0060041 4.4060662784898e-09 7.94628929992754e-08 510 871 508 4.00551480664918e-10 50 2.33230231062492 2.52543794815385 1 19.9234080874897 508 1712 183 50 1438 388 2935 890 1008 313 156 161 M11988 GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. 83/117 Gene Ontology BP GO:0030004 1.05045669262163e-07 4.02645553947883e-07 510 642.545454545455 509 9.54960675253521e-09 139 2.09759428244537 -1.98414101061507 -1 16.1202333241232 509 139 932 1250 1076 330 308 157 551 1323 493 162 M13759 GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of a protein along a microtubule, mediated by motor proteins. 39/44 Gene Ontology BP GO:0098840 5.41234680326125e-08 4.02645553947883e-07 225 1874.36363636364 510 4.92031539673954e-09 51 1.25408524110612 1.22482700412985 1 9.59637477507375 225 3706 3696 3935 315 51 75 287 4304 3514 510 163 M16836 GO_INTRACILIARY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT.html The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. 39/44 Gene Ontology BP GO:0042073 5.41234680326125e-08 4.02645553947883e-07 230 1878.81818181818 511 4.92031539673954e-09 52 1.25408524110612 1.22482700412985 1 9.59637477507375 226 3707 3697 3936 316 52 76 325 4305 3516 511 164 M11371 GO_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). 479/666 Gene Ontology BP GO:0001501 5.60507964471465e-17 3.72577651240818e-15 515 806.545454545455 513 5.09552694974058e-18 37 2.36570732017156 2.50129462355324 1 41.1789473298403 513 1459 37 370 1197 129 1868 831 2068 143 257 165 M13455 GO_SPINAL_CORD_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_PATTERNING.html The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. 17/34 Gene Ontology BP GO:0021511 2.57472224176555e-07 5.67433145203964e-07 515 617.363636363636 514 2.34065685735694e-08 76 2.90063411392883 2.82717860788709 1 21.8084292789575 514 965 759 174 2052 276 242 76 776 805 152 166 M13742 GO_MITOTIC_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. 90/105 Gene Ontology BP GO:0007052 3.42351496274863e-07 6.84715782949634e-07 340 1009.90909090909 514 3.11228681408789e-08 136 1.92313953533559 2.18255577206909 1 14.2346578631678 337 136 1954 1916 2270 398 514 404 1190 1663 327 167 M14241 GO_RESPONSE_TO_BMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 97/151 Gene Ontology BP GO:0071772 3.67330874333423e-07 7.13947601617969e-07 100 958 514 3.33937214241956e-08 96 2.46868384794138 2.69976282038206 1 18.2476569635753 96 103 293 1296 2338 514 1764 1279 2285 343 227 168 M15398 GO_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_GROWTH.html The increase in size or mass of the heart. 32/43 Gene Ontology BP GO:0060419 6.69696500246852e-08 4.02645553947883e-07 1070 816.181818181818 514 6.08815018757197e-09 262 2.94427786968676 3.04217446436275 1 22.6686444119221 1070 597 374 387 514 1179 2413 1524 262 307 351 169 M15778 GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 97/151 Gene Ontology BP GO:0071773 3.67330874333423e-07 7.13947601617969e-07 100 955 515 3.33937214241956e-08 97 2.46868384794138 2.69976282038206 1 18.2476569635753 97 104 294 1297 2339 515 1765 1236 2286 344 228 170 M10078 GO_MITOTIC_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CYTOKINESIS.html A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. 44/56 Gene Ontology BP GO:0000281 9.27538764704615e-08 4.02645553947883e-07 775 577.363636363636 516 8.43217094373133e-09 40 2.31514017764218 2.50112125002045 1 17.8027744453624 774 452 1113 40 915 541 516 353 41 1431 175 171 M15430 GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION.html The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. 405/616 Gene Ontology BP GO:0048667 1.46647660423011e-21 1.74961939473915e-19 680 761.545454545455 519 1.3331605493001e-22 19 2.40655882783522 2.72337814059817 1 54.4891894832363 677 1474 19 314 519 412 2733 814 948 59 408 172 M16247 GO_LIMBIC_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMBIC_SYSTEM_DEVELOPMENT.html The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. 112/180 Gene Ontology BP GO:0021761 7.35079884304057e-07 1.17266030051936e-06 150 844.090909090909 522 6.68254663558518e-08 62 2.13447133002568 2.40684160018867 1 15.2070230872129 194 62 880 967 2873 131 522 147 1908 1454 147 173 M11084 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. 20/25 Gene Ontology BP GO:0034143 4.11543190129932e-07 7.74953647784126e-07 290 807.090909090909 523 3.74130242832104e-08 55 2.41533934903114 -2.76574197794967 -1 17.7471093602964 288 901 1516 190 2421 523 322 378 55 1496 788 174 M10470 GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. 48/70 Gene Ontology BP GO:0060688 1.23613358049095e-07 4.14338946095474e-07 535 624.454545454545 534 1.12375786358791e-08 188 2.80607684776773 2.9053512444472 1 21.5575786695004 545 420 366 534 1274 733 1216 533 548 512 188 175 M12538 GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. 63/94 Gene Ontology BP GO:0003229 1.63419015149895e-07 4.49934128693763e-07 360 1059.27272727273 537 1.48562752080804e-08 262 2.7147411699311 2.91590620861821 1 20.735028404717 359 281 262 478 2362 1101 3239 1825 537 329 879 176 M12218 GO_ANATOMICAL_STRUCTURE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. 59/76 Gene Ontology BP GO:0071695 4.16219195719557e-08 4.02645553947883e-07 580 832.181818181818 539 3.78381094176392e-09 149 2.57331503166885 2.82755449337519 1 19.7995476227042 577 316 335 473 149 730 2470 1195 1985 539 385 177 M13527 GO_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. 82/126 Gene Ontology BP GO:0021675 1.2034831486946e-07 4.11313958327346e-07 765 751.272727272727 541 1.09407564957243e-08 80 2.37826987405534 2.4760484790005 1 18.2644243829714 762 154 418 541 1243 313 2404 877 1073 399 80 178 M15749 GO_LIPID_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_LOCALIZATION.html Any process in which a lipid is transported to, or maintained in, a specific location. 236/373 Gene Ontology BP GO:0010876 4.31198208347659e-10 9.46398709170594e-09 410 558 545 3.91998371301975e-11 9 2.41288220467467 -2.3593662680577 -1 23.3119276520437 407 1602 145 9 146 569 562 798 1052 303 545 179 M13631 GO_NEURON_PROJECTION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MORPHOGENESIS.html The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. 454/670 Gene Ontology BP GO:0048812 1.26260678859884e-22 1.80429235477148e-20 655 721.545454545455 548 1.14782435327168e-23 16 2.42669078651412 2.71837959994306 1 57.8414918700591 652 1455 16 304 633 493 2397 358 1029 52 548 180 M14319 GO_OLFACTORY_LOBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_LOBE_DEVELOPMENT.html The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. 44/61 Gene Ontology BP GO:0021988 6.86749562459614e-08 4.02645553947883e-07 865 688.363636363636 550 6.24317803542829e-09 359 2.59579128968843 2.75656959445259 1 19.9733832555728 864 448 359 550 541 473 1364 1054 793 743 383 181 M10902 GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any neuron projection extension that is involved in neuron projection guidance. 15/17 Gene Ontology BP GO:1902284 5.78620750158951e-06 7.10375290366649e-06 80 1197.45454545455 551 5.26020247265184e-07 80 3.49507885119877 3.59088085344579 1 21.6594893890344 80 1050 363 2192 3945 463 446 336 2229 551 1517 182 M12034 GO_AORTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_DEVELOPMENT.html The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. 81/106 Gene Ontology BP GO:0035904 2.20610867391404e-09 4.2949889789632e-08 135 913.181818181818 551 2.00555334193298e-10 133 2.90495329274535 3.45855973713575 1 25.7792351562194 133 191 169 551 3334 735 2532 864 937 373 226 183 M11804 GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE.html The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. 15/17 Gene Ontology BP GO:0048846 5.78620750158951e-06 7.10375290366649e-06 85 1197.72727272727 552 5.26020247265184e-07 81 3.49507885119877 3.59088085344579 1 21.6594893890344 81 1051 364 2193 3946 464 447 329 2230 552 1518 184 M12408 GO_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_DEVELOPMENT.html The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. 218/277 Gene Ontology BP GO:0060348 1.05253474975576e-10 2.64726713006137e-09 545 938.818181818182 552 9.56849772551015e-12 129 2.5212918930478 2.42009144274665 1 26.0510221921905 542 1629 129 399 552 247 1569 2607 1466 486 701 185 M12853 GO_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_GROWTH.html Any process that modulates the frequency, rate or extent of growth of an organ of an organism. 77/110 Gene Ontology BP GO:0046620 3.1762890430719e-08 3.85278716745714e-07 985 688.909090909091 554 2.88753553539102e-09 77 2.43337352376531 2.66139849332723 1 18.7735641378113 1249 180 452 146 77 554 984 1630 172 984 1150 186 M10271 GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT.html The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. 24/31 Gene Ontology BP GO:0060973 2.35820681368908e-09 4.51552934324909e-08 540 816.454545454545 555 2.14382437837897e-10 172 3.43723401262668 3.78128759024808 1 30.4312836901228 536 738 172 369 2240 555 1063 1700 471 337 800 187 M16290 GO_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of dendrite development. 162/194 Gene Ontology BP GO:0050773 1.51604524476667e-07 4.37874520415848e-07 405 670.727272727273 556 1.37822304476281e-08 143 2.17592999785523 2.41759326464568 1 16.6302372047814 404 1718 622 143 1516 173 556 385 794 870 197 188 M10363 GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. 220/300 Gene Ontology BP GO:0045665 4.50901830037504e-09 8.06940851986348e-08 805 645.636363636364 558 4.09910755419683e-10 164 2.40836938351902 2.79484359796387 1 20.5571108117897 801 1624 184 444 670 193 1402 558 796 266 164 189 M11168 GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. 36/51 Gene Ontology BP GO:0034122 1.23647774375732e-07 4.14338946095474e-07 310 715.545454545455 558 1.12407073931977e-08 97 2.16547391989563 -2.19243752359188 -1 16.6126666681694 310 558 964 97 1275 500 167 907 193 1110 1790 190 M12616 GO_MICROTUBULE_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_DEPOLYMERIZATION.html The removal of tubulin heterodimers from one or both ends of a microtubule. 12/16 Gene Ontology BP GO:0007019 1.8668663280954e-07 4.81781975852907e-07 560 878.363636363636 558 1.69715135137559e-08 41 2.45854345619652 2.78954264179939 1 18.6801759277526 558 1154 1647 1915 1720 349 41 110 306 1598 264 191 M15682 GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS.html The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. 139/167 Gene Ontology BP GO:0060560 1.42601601979697e-07 4.2854237685504e-07 555 925.272727272727 558 1.29637828384525e-08 212 2.21567371557197 2.53727854028678 1 16.9609421026429 555 1767 470 558 1447 212 1489 1068 1952 316 344 192 M15872 GO_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 143/188 Gene Ontology BP GO:0072006 1.77642882050947e-20 1.96802935757871e-18 1735 793.181818181818 559 1.61493529137224e-21 21 2.76792717383385 3.08251690184013 1 59.1681923287425 241 1734 21 322 1640 264 1732 1245 931 36 559 193 M16442 GO_CIRCULATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. 880/1179 Gene Ontology BP GO:0072359 5.05344403787416e-18 3.85470083741451e-16 450 1057.18181818182 562 5.05344403787419e-19 35 2.34130440424321 2.54528577575993 1 43.542847318716 447 1366 4623 319 562 137 1553 567 1740 35 280 194 M15118 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. 71/84 Gene Ontology BP GO:0045669 9.81794802136222e-08 4.02645553947883e-07 825 659.363636363636 565 8.92540769046197e-09 200 2.5803013956883 2.75190981054777 1 19.8535814841109 823 249 516 921 985 206 794 200 503 1491 565 195 M11378 GO_CRANIAL_NERVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 37/59 Gene Ontology BP GO:0021602 1.00788348560193e-07 4.02645553947883e-07 170 570.818181818182 569 9.16257756159985e-09 18 2.45506027163627 2.79562911591198 1 18.8849429304065 168 569 750 978 1018 102 297 34 1654 691 18 196 M13335 GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. 86/122 Gene Ontology BP GO:0031032 2.14675767929443e-07 5.12148364863292e-07 1510 973.545454545455 576 1.9515980807044e-08 97 2.88269665330409 3.3073114646776 1 21.8281371386622 1510 155 280 372 1877 1836 2949 97 470 587 576 197 M14694 GO_COCHLEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_DEVELOPMENT.html The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. 45/75 Gene Ontology BP GO:0090102 7.07913317945943e-08 4.02645553947883e-07 580 759.636363636364 579 6.43557582477354e-09 337 2.72829460527069 3.12375475798659 1 20.9981889728492 796 454 337 1061 578 818 1997 579 966 388 382 198 M16413 GO_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized. 194/279 Gene Ontology BP GO:0048705 2.63422668347346e-07 5.72483241320837e-07 285 1034.63636363636 579 2.39475181717222e-08 256 2.23550562546119 2.37747564403776 1 16.7736456511876 281 1668 298 579 2080 256 1350 1382 2618 327 542 199 M16425 GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. 119/153 Gene Ontology BP GO:0001936 1.8907269553292e-07 4.85434817396203e-07 585 816.272727272727 581 1.71884283438394e-08 46 2.42544780778633 2.51627035588746 1 18.4177046150832 581 46 327 125 1731 265 1219 1358 2224 448 655 200 M15830 GO_POST_ANAL_TAIL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_ANAL_TAIL_MORPHOGENESIS.html The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. 32/44 Gene Ontology BP GO:0036342 8.73867720419923e-08 4.02645553947883e-07 210 578.727272727273 582 7.94425231937319e-09 105 2.89767706254441 3.42757132640253 1 22.3082249508746 206 657 681 582 850 511 960 269 105 1144 401 201 M12414 GO_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 55/110 Gene Ontology BP GO:0051952 1.45393517565209e-07 4.33108858662559e-07 375 1278.54545454545 583 1.32175933794519e-08 373 2.83142527877793 2.93736218881347 1 21.6873587192657 2002 374 373 872 1465 2431 4402 458 555 549 583 202 M12511 GO_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 95/116 Gene Ontology BP GO:0006029 4.55466533011638e-09 8.11986888162127e-08 35 779.636363636364 584 4.14060485413264e-10 31 2.55795521420989 2.73953377554027 1 21.8319495976351 31 113 185 862 2426 280 962 762 2023 348 584 203 M13612 GO_MEIOTIC_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEPARATION.html The process in which chromosomes are physically detached from each other during meiosis. 9/12 Gene Ontology BP GO:0051307 1.18950016784867e-05 1.38784961910729e-05 425 1677.72727272727 585 1.18950653499456e-06 23 1.6721050291948 1.6721050291948 1 9.72038866250692 424 2293 4438 2414 4141 354 23 282 472 3029 585 204 M15469 GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of skeletal muscle contraction. 17/25 Gene Ontology BP GO:0014819 6.11955717922388e-07 1.02869579316939e-06 250 1322.45454545455 585 5.56323534677354e-08 174 2.4098234314325 2.6042207125498 1 17.3478369714902 246 2647 1728 3666 2726 279 328 174 585 1751 417 205 M14896 GO_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_DEVELOPMENT.html The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. 352/528 Gene Ontology BP GO:0001654 3.40390922638813e-12 1.09988816877666e-10 745 761.909090909091 588 3.09446293308491e-13 94 2.2403274670779 2.53964501447137 1 26.879471426446 743 1523 94 406 636 267 2729 588 1105 189 101 206 M10077 GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. 57/69 Gene Ontology BP GO:0007528 5.43463042922671e-07 9.39700311675655e-07 245 986.909090909091 594 4.94057433794238e-08 244 2.66991015207577 2.72024207180546 1 19.358152490751 244 350 495 594 2644 512 2377 1571 830 875 364 207 M13079 GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 87/98 Gene Ontology BP GO:0060998 1.50663927309632e-07 4.37329540718478e-07 390 738.363636363636 596 1.36967216025129e-08 144 2.0661065475505 2.34131003926088 1 15.7870315395798 390 144 1145 1370 1507 564 379 219 798 1010 596 208 M15104 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION.html The process in which epiblast cells acquire specialized features of neuroepithelial cells. 74/104 Gene Ontology BP GO:0060563 6.17120340331417e-08 4.02645553947883e-07 3520 1602.54545454545 597 5.61018506947467e-09 174 2.57619280021437 -2.27995013689978 -1 19.8218048292162 3520 174 242 438 430 3800 2887 3165 597 405 1970 209 M14097 GO_VIRION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRION_ASSEMBLY.html A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. 42/47 Gene Ontology BP GO:0019068 7.18246381645304e-08 4.02645553947883e-07 90 1820.36363636364 599 6.52951277358452e-09 21 1.06275708070677 -0.953459669277385 -1 8.11660657613015 87 3221 3850 3972 599 48 21 68 3901 4185 72 210 M16748 GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structure of the retina is generated and organized. 54/80 Gene Ontology BP GO:0060042 1.06840200099409e-07 4.02645553947883e-07 1595 1005.72727272727 600 9.71274593526978e-09 60 2.39171410515177 2.74511389310512 1 18.395011691361 1593 341 456 60 1100 1953 3718 156 473 600 613 211 M16349 GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. 911/1347 Gene Ontology BP GO:0007417 1.33089843170383e-07 4.20399283289481e-07 605 1217 602 1.33089851141191e-08 245 2.23454155715328 2.47618901554264 1 17.1287681180395 602 1363 4616 360 1468 269 1961 551 1614 338 245 212 M13343 GO_PALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. 202/287 Gene Ontology BP GO:0021543 2.42328958044966e-07 5.50444561636596e-07 95 729.363636363636 605 2.20299077033991e-08 40 2.17222868638511 2.45007426078832 1 16.3407359232166 94 1656 349 605 1985 40 733 184 1552 702 123 213 M13157 GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). 29/36 Gene Ontology BP GO:0001941 1.56966636039095e-07 4.4211002269365e-07 825 599.545454545455 606 1.42696952034932e-08 78 2.80445786944745 3.38672500086995 1 21.4495216158458 821 662 397 136 1564 606 1054 95 852 330 78 214 M13376 GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of cardiac muscle tissue are generated and organized. 72/112 Gene Ontology BP GO:0055008 1.47886926001716e-09 2.97886522374886e-08 610 1070.45454545455 606 1.34442660091934e-10 162 2.89647077395315 3.09349895640889 1 26.2603220588426 606 227 162 468 2219 908 3585 1797 926 350 527 215 M12873 GO_CEREBRAL_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_DEVELOPMENT.html The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. 144/190 Gene Ontology BP GO:0021987 2.16719004253783e-07 5.13962042198191e-07 120 786.909090909091 609 1.97017296002254e-08 118 2.29607157392398 2.57789414195985 1 17.3609241941495 118 1764 355 609 1891 121 769 528 1537 617 347 216 M16294 GO_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXONOGENESIS.html Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. 197/250 Gene Ontology BP GO:0050770 2.26243962401486e-08 3.25046758377561e-07 735 843.181818181818 610 2.05676331571035e-09 185 2.35681767511186 2.80801989546574 1 18.3901313358397 735 1649 217 873 424 580 2493 185 1170 339 610 217 M12259 GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. 36/55 Gene Ontology BP GO:0043534 8.2552557784273e-08 4.02645553947883e-07 615 405.363636363636 611 7.50477826199693e-09 1 2.61034938387689 2.92720295562676 1 20.0859783109601 156 611 635 611 776 124 115 30 775 625 1 218 M11376 GO_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_CONTRACTION.html Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. 210/333 Gene Ontology BP GO:0008016 1.43046999030251e-18 1.279995550938e-16 545 884.909090909091 612 1.30042726391137e-19 26 2.68671880500316 2.82000876348663 1 51.5376579218672 543 1623 26 1239 612 171 1506 1771 1746 66 431 219 M15685 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 98/149 Gene Ontology BP GO:0021954 6.6655653339026e-07 1.09238236955647e-06 520 908 613 6.05960668494368e-08 109 2.65535505348429 2.95943610720198 1 19.0420826018479 519 109 320 971 2794 457 1475 264 1820 613 646 220 M11569 GO_SARCOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOMERE_ORGANIZATION.html The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. 35/61 Gene Ontology BP GO:0045214 9.73497266874337e-08 4.02645553947883e-07 730 685.909090909091 616 8.84997554501336e-09 111 3.70962327088477 3.97683645483718 1 28.5879705766469 730 616 250 346 1042 1191 1777 111 375 839 268 221 M12211 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. 20/40 Gene Ontology BP GO:0099623 7.30675064961509e-08 4.02645553947883e-07 720 760 616 6.64250081117323e-09 15 3.56188385057216 4.06181227123097 1 27.4453259421475 719 887 277 857 616 1184 2760 15 248 543 254 222 M15050 GO_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 137/182 Gene Ontology BP GO:0032526 2.71669203031757e-07 5.83061255399799e-07 805 1169.90909090909 616 2.46972033253733e-08 8 2.67629675686132 2.88635132619306 1 20.0755936577148 805 8 385 267 2108 593 2516 2852 2165 616 554 223 M15221 GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of embryonic development. 140/180 Gene Ontology BP GO:0045995 8.76397378385346e-08 4.02645553947883e-07 275 842.818181818182 617 7.96724921179754e-09 64 2.30404209932857 2.54804521094584 1 17.7169398075151 273 1790 537 617 854 353 1980 641 1586 576 64 224 M12264 GO_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CONTRACTION.html A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. 118/194 Gene Ontology BP GO:0006941 1.45582730533495e-09 2.94520193553197e-08 1770 1108.90909090909 618 1.32347936936212e-10 4 2.70605110188473 3.02267840876442 1 24.5433015850703 1767 4 161 361 153 1975 4531 840 618 426 1362 225 M10109 GO_ATP_DEPENDENT_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. 77/200 Gene Ontology BP GO:0043044 9.33752939816228e-07 1.4189263321244e-06 50 1313.90909090909 619 8.48866669211062e-08 46 1.5976169207318 1.73618748756106 1 11.1963543691116 46 232 2731 2849 3026 119 153 613 1070 2995 619 226 M11549 GO_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_PROLIFERATION.html The expansion of a muscle cell population by cell division. 28/33 Gene Ontology BP GO:0033002 7.09176506620646e-08 4.02645553947883e-07 2045 1174.27272727273 621 6.44705935891963e-09 222 2.73571833756811 2.79079287119627 1 21.0556055232841 2043 701 621 448 581 2440 3129 1939 222 481 312 227 M10103 GO_REGULATION_OF_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GOLGI_ORGANIZATION.html Any process that modulates the frequency, rate or extent of Golgi organization. 19/19 Gene Ontology BP GO:1903358 1.66692076214887e-06 2.29812809074924e-06 900 1239 622 1.51538365923772e-07 104 1.88992135007055 -1.90093317660363 -1 12.7850566030635 896 1004 2740 212 3344 533 357 568 104 3249 622 228 M10373 GO_CARDIAC_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_DEVELOPMENT.html The progression of a cardiac septum over time, from its initial formation to the mature structure. 113/145 Gene Ontology BP GO:0003279 9.61294346032211e-08 4.02645553947883e-07 1045 828.181818181818 622 8.73903989123784e-09 38 2.20792287401097 2.60761345098159 1 16.9735355295708 1045 38 493 759 954 1017 3112 595 622 320 155 229 M10398 GO_CELL_PART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PART_MORPHOGENESIS.html The process in which the anatomical structures of a cell part are generated and organized. 711/988 Gene Ontology BP GO:0032990 2.55491032664754e-10 6.00403926762172e-09 1395 1002.09090909091 624 2.55491032694128e-11 116 2.15179673841445 2.29942822692774 1 21.2926337831968 522 1392 4237 342 377 229 1129 624 1392 116 663 230 M11998 GO_FOREBRAIN_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_CELL_MIGRATION.html The orderly movement of a cell from one site to another at least one of which is located in the forebrain. 67/93 Gene Ontology BP GO:0021885 8.00620922665836e-08 4.02645553947883e-07 430 601.909090909091 624 7.27837228910837e-09 118 2.46614712916041 2.77049269722812 1 18.9706907845447 426 253 371 935 735 360 1030 118 953 816 624 231 M13997 GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. 51/57 Gene Ontology BP GO:0045992 5.48565055269382e-07 9.46061231344861e-07 80 965.272727272727 625 4.98695629138995e-08 78 2.55970835862304 2.67722236132757 1 18.5458160110362 78 408 415 608 2653 442 926 1985 1821 657 625 232 M13368 GO_GRANULOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_MIGRATION.html The movement of a granulocyte within or between different tissues and organs of the body. 61/100 Gene Ontology BP GO:0097530 2.05886557109738e-07 5.00778959870156e-07 495 1200.45454545455 626 1.8716961488872e-08 359 2.69651642371729 -2.98474001779484 -1 20.4435031228985 493 359 523 2690 1837 626 564 503 3561 866 1183 233 M12951 GO_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. 37/52 Gene Ontology BP GO:0045445 9.32801248987478e-08 4.02645553947883e-07 1875 744.636363636364 627 8.48001171398459e-09 114 2.33656458786753 2.70082204332867 1 17.9684748883417 1874 540 656 157 920 1399 1097 114 353 454 627 234 M11224 GO_CEREBELLAR_CORTEX_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 38/57 Gene Ontology BP GO:0021696 2.60833124756489e-08 3.53835722883948e-07 2890 1321.72727272727 628 2.37121025317219e-09 40 2.63132683985202 2.80741663359453 1 20.4268176241385 2889 539 578 56 40 2432 2596 2217 574 628 1990 235 M12126 GO_MELANIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. 9/18 Gene Ontology BP GO:0006582 4.62834836832538e-07 8.40141046894164e-07 630 1027.63636363636 630 4.62834933229805e-08 17 2.52693292358819 -2.54906463878558 -1 18.4646226240084 630 1176 4345 57 2600 739 163 145 17 919 513 236 M14556 GO_DIENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. 63/125 Gene Ontology BP GO:0021536 5.09763415574582e-07 8.95743645267571e-07 575 1271.45454545455 630 4.63421394265662e-08 330 2.50004046659839 2.56390041199148 1 18.1828704696025 574 330 532 1820 2602 461 431 2313 2941 630 1352 237 M15281 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT.html Any process that modulates the frequency, rate or extent of actin filament-based movement. 44/71 Gene Ontology BP GO:1903115 7.4062268261828e-08 4.02645553947883e-07 345 1554 631 6.73293370501e-09 341 2.64277996143882 2.8221221670392 1 20.3368025348974 2812 470 551 881 631 3158 4290 341 343 418 3199 238 M14615 GO_MUSCLE_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_FATE_COMMITMENT.html The process in which the cellular identity of muscle cells is acquired and determined. 5/19 Gene Ontology BP GO:0042693 4.58183344768307e-06 5.73561233039261e-06 585 1664.54545454545 632 4.58184289464946e-07 91 3.32315315071993 3.32315315071993 1 20.9623760030103 585 3104 4504 2029 3908 632 91 188 131 2619 519 239 M10831 GO_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. 14/28 Gene Ontology BP GO:0046068 1.10798447411385e-08 1.82171440213843e-07 450 807.181818181818 634 1.00725861790362e-09 2 2.49579445333158 2.33893238569242 1 20.2396568650681 450 1035 1009 1263 2 522 278 2838 130 634 718 240 M13617 GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 35/45 Gene Ontology BP GO:0060314 9.38360237075681e-08 4.02645553947883e-07 255 945.727272727273 635 8.53054797363013e-09 171 2.10627623247601 2.13552185517209 1 16.1873811686085 252 635 1737 1822 926 200 325 226 2374 1735 171 241 M11014 GO_ENDOSOME_TO_LYSOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_TO_LYSOSOME_TRANSPORT.html The directed movement of substances from endosomes to lysosomes. 50/55 Gene Ontology BP GO:0008333 1.7910157029944e-07 4.713572435539e-07 130 1544.90909090909 636 1.62819622618242e-08 89 1.07511923416299 -1.10647343082124 -1 8.12324549288994 128 486 3900 2956 1686 89 168 589 2566 3790 636 242 M13151 GO_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MORPHOGENESIS.html Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 834/1215 Gene Ontology BP GO:0009887 2.76522951725363e-22 3.67617512679462e-20 640 1101.36363636364 640 2.76522951725364e-23 19 2.46628427387383 2.69844970457408 1 57.8649779118096 640 1369 4411 281 786 222 2477 456 1238 19 216 243 M15272 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. 39/52 Gene Ontology BP GO:0001937 2.46507540765147e-07 5.55178890213083e-07 265 869.181818181818 641 2.2409778944186e-08 103 2.55265235775112 2.83400386513257 1 19.2090472569192 263 604 962 103 2003 717 1789 331 494 1654 641 244 M13874 GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. 21/35 Gene Ontology BP GO:0034142 1.05677086018153e-07 4.02645553947883e-07 965 591.727272727273 642 9.60700828130515e-09 74 2.93154231924988 -3.4755455133531 -1 22.5701452548027 961 869 677 74 1085 647 393 640 192 642 329 245 M13894 GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. 65/71 Gene Ontology BP GO:0034446 6.92954390775089e-08 4.02645553947883e-07 465 727.909090909091 642 6.2995855691065e-09 77 2.24731065145914 2.47847757326291 1 17.2781680539897 462 288 751 908 558 319 2391 642 783 828 77 246 M12381 GO_PATTERNING_OF_BLOOD_VESSELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERNING_OF_BLOOD_VESSELS.html The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. 62/76 Gene Ontology BP GO:0001569 2.4971224206906e-06 3.2803813166215e-06 110 1210.27272727273 645 2.27011386824364e-07 107 2.61615333721514 2.91526989508858 1 17.2484870249772 107 1881 338 645 3528 376 1710 1867 2194 363 304 247 M13032 GO_EMBRYONIC_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PATTERN_SPECIFICATION.html The process that results in the patterns of cell differentiation that will arise in an embryo. 67/93 Gene Ontology BP GO:0009880 1.30410303209688e-07 4.18739690741189e-07 1960 1248.81818181818 645 1.1855482812734e-08 118 2.56681296679635 2.92179835950971 1 19.6964205040221 1959 244 361 118 1343 1729 2828 3372 534 604 645 248 M15121 GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 38/55 Gene Ontology BP GO:0002756 1.06694780676011e-06 1.56955679571761e-06 45 1038.18181818182 645 9.69953022004401e-08 24 1.95827824669477 -2.04941590316553 -1 13.6433953391985 44 615 1965 1583 3126 79 24 645 1003 1792 544 249 M16085 GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. 23/36 Gene Ontology BP GO:0048486 4.50997614498703e-08 4.02645553947883e-07 230 725.090909090909 645 4.09997839767368e-09 12 2.62184288709728 2.78061303728039 1 20.1748712398655 229 837 645 911 1268 209 569 12 2462 653 181 250 M12068 GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. 12/17 Gene Ontology BP GO:0032460 1.6386636764457e-08 2.55862486124223e-07 650 1239.90909090909 647 1.48969426241022e-09 5 4.09875523912699 -3.72664214292797 -1 32.5737095844153 647 3369 1684 101 3013 968 274 5 13 3494 71 251 M16580 GO_BONE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. 31/37 Gene Ontology BP GO:0070977 4.58909026549332e-08 4.02645553947883e-07 400 801.727272727273 647 4.17190032838133e-09 49 2.87951917866085 3.13270793859003 1 22.1677884407711 399 1989 647 489 190 415 905 1140 1107 1489 49 252 M15882 GO_NOTOCHORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTOCHORD_DEVELOPMENT.html The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. 39/52 Gene Ontology BP GO:0030903 2.09698455974458e-06 2.81270370610883e-06 175 1141.90909090909 649 1.90635141685462e-07 174 2.60299896177546 2.99125898180705 1 17.3715330897544 174 537 451 649 3439 899 1431 2554 1471 377 579 253 M12554 GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. 18/26 Gene Ontology BP GO:0051447 5.75043030929852e-08 4.02645553947883e-07 355 1043.27272727273 653 5.22766405418647e-09 85 1.68039656835343 1.45587678868978 1 12.8935472539878 355 982 2140 2215 366 140 85 946 653 3151 443 254 M16233 GO_REGULATION_OF_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. 29/51 Gene Ontology BP GO:0060306 1.60095261141645e-08 2.51306948561457e-07 655 658.818181818182 654 1.45541147551516e-09 37 3.51456550368781 3.78396066407885 1 27.949513764035 654 674 206 859 754 800 2320 37 399 425 119 255 M11931 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. 74/109 Gene Ontology BP GO:0034121 3.73599541533108e-07 7.21909745329548e-07 395 751.454545454545 655 3.39636004524582e-08 220 2.43019664873076 -2.45987946273172 -1 17.9474115325657 391 220 568 699 2357 655 370 683 332 830 1161 256 M12739 GO_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of neuron differentiation. 614/801 Gene Ontology BP GO:0045664 1.18635384351349e-17 8.76207052994963e-16 660 1003.72727272727 657 1.18635384351349e-18 38 2.31929327851623 2.57537241621039 1 42.1322341437952 657 1401 4385 310 554 57 1531 861 1097 38 150 257 M13572 GO_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION.html A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. 174/242 Gene Ontology BP GO:0007369 6.13935602896399e-08 4.02645553947883e-07 245 973.636363636364 658 5.58123290935443e-09 218 2.08998038943422 2.37151728993322 1 16.0613460347428 218 1707 386 1326 425 244 1518 1512 2472 658 244 258 M11331 GO_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEPARATION.html The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). 17/21 Gene Ontology BP GO:0051304 4.02059484609376e-06 5.07262142594204e-06 435 1538.36363636364 660 3.65509290356634e-07 45 1.56387568767383 1.70027611342194 1 9.91128544796127 433 2663 2891 2003 3662 333 45 371 660 3372 489 259 M10699 GO_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CONDENSATION.html The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. 30/40 Gene Ontology BP GO:0030261 5.73848914410517e-07 9.83107142397694e-07 220 1231.09090909091 661 5.21680967357783e-08 220 2.02929625951735 2.24602644835055 1 14.6405543948695 220 2022 2418 1967 2673 443 354 452 661 1676 656 260 M10503 GO_MYELOID_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MIGRATION.html The movement of a myeloid leukocyte within or between different tissues and organs of the body. 85/150 Gene Ontology BP GO:0097529 1.93721750465341e-07 4.91487080106452e-07 325 1097 664 1.76110697748707e-08 208 2.62773527315577 -2.84097036278689 -1 19.9452656710504 321 208 376 2013 1753 664 488 441 3859 814 1130 261 M12054 GO_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_PRECURSOR_CELL_PROLIFERATION.html The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. 87/155 Gene Ontology BP GO:0061351 4.8172546362968e-08 4.02645553947883e-07 795 663 664 4.37932249252579e-09 48 1.98446431348427 2.4002846525235 1 15.2452647357738 792 159 1450 1153 219 225 1170 255 664 1158 48 262 M16952 GO_POSITIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSSIFICATION.html Any process that activates or increases the frequency, rate or extent of bone formation. 96/117 Gene Ontology BP GO:0045778 5.08059769227298e-08 4.02645553947883e-07 2020 1028.18181818182 664 4.61872528145673e-09 108 2.49738923982746 2.73205904730644 1 19.2123231806148 2016 108 394 528 258 1242 2663 664 647 1393 1397 263 M11203 GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 11/13 Gene Ontology BP GO:0009313 1.20362081757122e-07 4.11313958327346e-07 340 1393.72727272727 669 1.09420080311034e-08 18 1.89956172222467 -1.98803476330255 -1 14.5673605323319 339 1213 2804 3169 3899 669 294 18 502 2377 47 264 M13538 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. 35/47 Gene Ontology BP GO:0055025 7.790531153479e-08 4.02645553947883e-07 855 713.636363636364 670 7.08230129941222e-09 232 2.4209895927074 2.33627545767744 1 18.6214338521291 855 570 670 232 696 370 441 1637 270 1236 873 265 M13864 GO_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MIGRATION.html The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. 121/181 Gene Ontology BP GO:0001764 4.17986709484775e-08 4.02645553947883e-07 510 766.909090909091 672 3.79987924932973e-09 22 2.70043560377485 2.97254652012841 1 20.7827221833195 507 22 229 851 1809 1116 1846 208 672 395 781 266 M16771 GO_INTESTINAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_ABSORPTION.html Any process in which nutrients are taken up from the contents of the intestine. 37/58 Gene Ontology BP GO:0050892 7.65339230889236e-08 4.02645553947883e-07 440 810.090909090909 672 6.95762961376338e-09 438 3.12463725553298 -3.22599540620365 -1 24.0635780327711 871 633 562 440 672 1005 438 462 734 1982 1112 267 M14360 GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 54/68 Gene Ontology BP GO:0030166 2.48988787686813e-07 5.59143257290898e-07 135 1159 674 2.26353468969593e-08 131 2.49043573487582 2.55411660140386 1 18.7290422040425 131 438 731 3647 2010 245 500 170 2728 1475 674 268 M11337 GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY.html The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. 14/34 Gene Ontology BP GO:0007214 1.48171645399701e-06 2.07102032455635e-06 620 1075.45454545455 676 1.3470158654046e-07 49 2.76223503169961 2.92565420773965 1 18.8846224026343 616 2188 1045 1712 3297 676 400 167 49 1203 477 269 M14176 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a ventricular cardiac muscle cell. 16/30 Gene Ontology BP GO:0086005 5.14510817251768e-08 4.02645553947883e-07 4045 1252 677 4.67737117531415e-09 103 3.40588957282462 -3.2695448921246 -1 26.2388366781198 4041 940 289 356 263 3511 2156 1269 103 677 167 270 M16286 GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. 65/98 Gene Ontology BP GO:0003143 7.67716397522493e-08 4.02645553947883e-07 680 766.909090909091 679 6.97924022102617e-09 192 2.13779080894151 2.16497071436164 1 16.4311208667245 825 276 1001 724 679 390 1989 1152 679 529 192 271 M13364 GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. 33/41 Gene Ontology BP GO:0048485 6.06595649836362e-07 1.02182520155145e-06 125 743.090909090909 680 5.51450742809264e-08 91 2.86703966434275 3.36609431820385 1 20.6688707343266 123 680 708 630 2720 143 686 91 1075 1015 303 272 M14599 GO_LIMB_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMB_DEVELOPMENT.html The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. 209/288 Gene Ontology BP GO:0060173 1.61282405373305e-07 4.4655132638076e-07 265 916.363636363636 681 1.46620379269953e-08 138 2.26482340080432 2.54614065011565 1 17.2904978870487 265 1648 411 603 1593 187 1627 681 2045 882 138 273 M11972 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. 73/145 Gene Ontology BP GO:0002718 2.29047048771233e-06 3.03634164653147e-06 110 1089.54545454545 682 2.08224806579745e-07 106 1.91010123418445 -1.96482289861536 -1 12.6432059460005 106 224 1071 1508 3475 195 594 739 2895 682 496 274 M15296 GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 29/51 Gene Ontology BP GO:0035249 8.50610234195995e-08 4.02645553947883e-07 685 866.727272727273 684 7.73282060985525e-09 198 2.94516373109391 3.27226363895498 1 22.675495831683 966 682 513 679 807 979 1796 1664 198 684 566 275 M12799 GO_NEPHRON_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. 101/140 Gene Ontology BP GO:0072009 4.81989015301021e-15 2.2653483719148e-13 1090 829.727272727273 686 4.38171832091837e-16 26 2.58487846318572 2.92296103550559 1 39.4267255070542 1090 42 75 26 348 695 2644 1983 686 58 1480 276 M13677 GO_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. 610/798 Gene Ontology BP GO:0035295 3.32115320157752e-19 3.09066516938804e-17 690 1117 688 3.32115320157753e-20 12 2.31306037164007 2.47529237946994 1 46.0821205235648 688 1408 4442 24 327 12 1928 1744 1477 26 211 277 M15784 GO_REGULATION_OF_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_CONDUCTION.html Any process that modulates the frequency, rate or extent of cardiac conduction. 67/91 Gene Ontology BP GO:1903779 1.01719606928369e-07 4.02645553947883e-07 660 976.363636363636 688 9.24723742104513e-09 257 2.21723665687253 2.22336326108067 1 17.0455700887368 659 257 632 1723 1034 309 688 1507 2710 326 895 278 M14323 GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. 36/54 Gene Ontology BP GO:0031663 1.81001523831476e-07 4.72615090004408e-07 375 759.181818181818 689 1.64546853384629e-08 194 2.54769544975387 -3.02462700793226 -1 19.3869982868235 374 586 899 194 1700 300 337 689 1314 922 1036 279 M10607 GO_INTERMEDIATE_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_ORGANIZATION.html Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 20/32 Gene Ontology BP GO:0045109 6.41169256811032e-08 4.02645553947883e-07 945 904.727272727273 694 5.82881159543006e-09 363 4.21151521680857 4.89416845585711 1 32.4696978630734 549 942 471 363 466 694 760 2597 526 944 1640 280 M15091 GO_PROTEIN_LOCALIZATION_TO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_SYNAPSE.html Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 17/20 Gene Ontology BP GO:0035418 1.7447024853635e-06 2.39189766187282e-06 695 1405 696 1.58609442635944e-07 186 2.96934538771013 3.40863876863304 1 20.0836432110183 691 2163 725 3168 3363 422 290 186 3158 593 696 281 M10875 GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. 30/37 Gene Ontology BP GO:0032793 6.0019852270804e-07 1.01484919564643e-06 230 1081.45454545455 697 5.45635169502517e-08 127 2.14911231974069 2.42133490646512 1 15.4751881979535 227 758 1981 1452 2708 679 421 127 697 2308 538 282 M11916 GO_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CHEMOTAXIS.html The movement of a leukocyte in response to an external stimulus. 92/167 Gene Ontology BP GO:0030595 2.03916613203479e-07 4.99381053281994e-07 300 1057.36363636364 698 1.85378756458531e-08 152 2.69968054430641 -2.92328705264316 -1 20.4715762904179 296 152 267 1526 1836 698 723 529 3664 568 1372 283 M16014 GO_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIOGENESIS.html Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. 98/139 Gene Ontology BP GO:0014013 6.85619422431753e-08 4.02645553947883e-07 4410 2086.72727272727 698 6.23290403453412e-09 101 2.4461906540688 2.94790396488309 1 18.8163436296777 4410 101 416 606 538 4577 3461 3928 563 698 3656 284 M14635 GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. 23/38 Gene Ontology BP GO:0002367 5.94546431766287e-08 4.02645553947883e-07 705 1007 701 5.40496770758007e-09 209 2.37061142788739 -2.37511240784453 -1 18.2317995919857 701 2603 1866 262 396 810 209 674 485 2359 712 285 M10255 GO_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 56/64 Gene Ontology BP GO:0010883 6.12058347325728e-08 4.02645553947883e-07 100 1034.90909090909 703 5.56416694867e-09 99 2.24089332229974 -2.06981134923025 -1 17.2285352158732 99 1897 1539 2214 421 104 169 703 2765 1275 198 286 M13350 GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 61/86 Gene Ontology BP GO:0050922 3.85406729477837e-08 4.02645553947883e-07 460 809.454545454545 703 3.5036976020871e-09 103 2.68305928509677 2.71816119357692 1 20.6483304464165 458 293 226 847 1759 703 949 103 1976 184 1406 287 M10094 GO_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. 124/154 Gene Ontology BP GO:0016358 1.61468203756113e-07 4.4655132638076e-07 480 771.090909090909 704 1.46789286915468e-08 11 2.20649985212913 2.48164565269113 1 16.8425830257878 478 11 704 955 1594 631 1230 231 1081 979 588 288 M16368 GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving mucopolysaccharide. 105/130 Gene Ontology BP GO:1903510 1.01263108544039e-07 4.02645553947883e-07 470 943.545454545455 704 9.20573756409522e-09 66 2.22151144107387 2.48247723032286 1 17.0786320786984 468 66 313 2161 1024 588 704 886 2120 384 1665 289 M11568 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of epithelial cell proliferation. 186/243 Gene Ontology BP GO:0050679 6.55451111416519e-10 1.40544424950279e-08 1265 979.636363636364 707 5.95864646919816e-11 149 2.33339705428135 2.54138543941523 1 22.055945099635 1262 1686 149 557 221 1162 2155 391 2308 178 707 290 M15524 GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. 79/105 Gene Ontology BP GO:0007422 7.3495208444645e-08 4.02645553947883e-07 915 909.363636363636 707 6.6813828090812e-09 181 2.31512830347093 2.53782224972888 1 17.8026826082749 912 181 592 897 624 707 3286 714 1013 649 428 291 M15378 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. 37/41 Gene Ontology BP GO:0071526 1.59981006523035e-07 4.46003173442602e-07 380 932.545454545455 708 1.45437289233306e-08 142 2.40481300448145 2.78333333238669 1 18.3671454871074 378 548 633 1264 1584 708 1701 142 2005 456 839 292 M15674 GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune effector process. 410/673 Gene Ontology BP GO:0002697 2.03241072605448e-07 4.99303437609901e-07 530 1105.45454545455 708 1.84764628528482e-08 437 2.09492476173702 -2.04524261799208 -1 15.8628433187743 528 1499 437 1699 1821 575 708 1005 2962 441 485 293 M14332 GO_MECHANORECEPTOR_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANORECEPTOR_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. 61/96 Gene Ontology BP GO:0042490 3.12169243199758e-08 3.84265473176845e-07 2780 1373.36363636364 709 2.83790225117534e-09 72 2.33524711893682 2.5259490730816 1 18.0155935574059 2780 287 709 517 72 2449 4285 2322 445 1134 107 294 M14506 GO_AMMONIUM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSPORT.html The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 46/97 Gene Ontology BP GO:0015696 3.93878504572477e-08 4.02645553947883e-07 840 839 709 3.58071374203916e-09 133 2.22249719030876 -1.89277896282347 -1 17.0862560498215 839 476 1229 1523 133 681 560 1048 632 1399 709 295 M10531 GO_CIRCULATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. 359/596 Gene Ontology BP GO:0003013 1.29313254400351e-23 2.00564857574944e-21 565 906.363636363636 710 1.17557504000319e-24 15 2.4711693435297 2.73157420559546 1 61.7548539903695 563 1514 15 328 1133 538 2645 859 1626 39 710 296 M12206 GO_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_FORMATION.html The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. 32/47 Gene Ontology BP GO:0048645 2.93431392155641e-07 6.1534076669006e-07 350 934.090909090909 710 2.6675584662992e-08 177 2.63723269993663 2.73344294498937 1 19.7064230509234 348 710 1303 258 2160 253 340 816 177 2890 1020 297 M13942 GO_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_MORPHOGENESIS.html The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. 535/783 Gene Ontology BP GO:0048598 2.47492943767608e-09 4.68123848516536e-08 710 1232.81818181818 710 2.47492944043245e-10 51 2.12026570232681 2.32860148991912 1 18.6920234629721 710 1425 4462 374 529 109 2489 1602 1671 139 51 298 M11199 GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX.html The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. 14/18 Gene Ontology BP GO:0021819 2.80121891616205e-07 5.95298733682208e-07 470 1435.36363636364 713 2.54656297530554e-08 38 1.91268088045012 2.03992610406183 1 14.2972703436346 467 2696 2497 659 3586 602 713 38 774 3358 399 299 M11437 GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. 27/44 Gene Ontology BP GO:0045920 1.47116133355802e-07 4.36007241085699e-07 425 1124.09090909091 713 1.3374194835782e-08 143 1.7911275725591 -1.71196270395294 -1 13.6750750620399 425 826 2579 1648 1472 656 143 369 333 3201 713 300 M11889 GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. 468/638 Gene Ontology BP GO:0060627 5.73752797922579e-08 4.02645553947883e-07 715 878.636363636364 713 5.21593466259876e-09 362 2.02200483665163 -1.85589078428633 -1 15.5356102460155 713 1456 600 377 362 586 913 1411 1297 423 1527 301 M16466 GO_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION.html Long distance growth of a single axon process involved in cellular development. 53/63 Gene Ontology BP GO:0048675 5.61907298655697e-07 9.66206452566504e-07 110 878.454545454545 713 5.10824947430768e-08 63 2.41833670028436 2.72533342013003 1 17.4890884786193 108 383 713 937 2676 258 1137 63 2014 904 470 302 M10848 GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. 64/98 Gene Ontology BP GO:2000737 5.25357100458396e-08 4.02645553947883e-07 3780 1848.36363636364 716 4.77597375458048e-09 276 2.36308905246601 2.46613003294291 1 18.1736201169631 3778 296 716 555 276 4543 3749 3258 366 665 2130 303 M16254 GO_AXIS_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_ELONGATION.html The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. 35/43 Gene Ontology BP GO:0003401 8.73970233264846e-08 4.02645553947883e-07 250 905.818181818182 717 7.94518425440111e-09 182 2.14465850159923 2.40259503986573 1 16.4842369013626 755 598 1360 250 852 246 553 3611 717 840 182 304 M12114 GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of epithelial cell proliferation. 327/422 Gene Ontology BP GO:0050678 3.23194436812986e-14 1.37965478393653e-12 1055 949.454545454545 722 2.93813124375445e-15 66 2.25627543517967 2.50325026034863 1 32.2604481112639 1052 1534 66 430 387 716 2024 1475 1949 89 722 305 M10515 GO_NEURON_PROJECTION_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION.html Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 72/84 Gene Ontology BP GO:1990138 3.90242578432791e-07 7.46934889941495e-07 260 857.181818181818 723 3.54766043322911e-08 51 2.33418442058578 2.73540199001653 1 17.1924980921846 260 240 723 1320 2423 307 1031 51 1806 846 422 306 M14996 GO_DEVELOPMENTAL_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_CELL_GROWTH.html The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. 102/120 Gene Ontology BP GO:0048588 1.9933458810798e-07 4.93878508235586e-07 730 1023.81818181818 726 1.81213278335471e-08 99 2.32974800873327 2.63382375325468 1 17.6658416828882 726 99 800 577 1800 674 2714 453 1858 864 697 307 M12452 GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. 73/109 Gene Ontology BP GO:0035050 3.47097985615068e-08 3.99952679980378e-07 1460 1027.36363636364 727 3.15543628264814e-09 96 2.08254377638607 2.10865703280412 1 16.0111698765779 1458 222 1037 727 96 998 2743 2425 720 509 366 308 M16947 GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. 108/199 Gene Ontology BP GO:0002700 8.465860437614e-07 1.31174321066327e-06 135 1096 729 7.69623972307188e-08 74 1.91539885409047 -1.95973507767111 -1 13.5229176552375 134 74 1305 1524 2962 399 846 372 3147 729 564 309 M11227 GO_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DIFFERENTIATION.html The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. 179/262 Gene Ontology BP GO:0001649 1.88501183657753e-07 4.84583429590898e-07 300 936.181818181818 730 1.71364727099073e-08 261 2.36321431771287 2.38905237424627 1 17.9446700323425 300 1720 414 623 1729 261 1007 708 1576 1230 730 310 M16375 GO_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_MATURATION.html Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 22/23 Gene Ontology BP GO:0090128 3.45784774850385e-07 6.88167903070505e-07 525 839.636363636364 731 3.14349844726439e-08 54 2.42968635252506 2.31294221070602 1 18.0047073628398 524 883 1278 188 2280 731 1052 54 404 1200 642 311 M11578 GO_ADULT_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_LOCOMOTORY_BEHAVIOR.html Locomotory behavior in a fully developed and mature organism. 85/161 Gene Ontology BP GO:0008344 1.14175093106422e-07 4.07093263007034e-07 1660 1208.81818181818 732 1.03795544574413e-08 133 2.25752877569332 2.85617614033676 1 17.3441709209566 1660 142 732 518 1187 2308 4556 573 565 923 133 312 M12808 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. 74/90 Gene Ontology BP GO:0010633 1.92920569294247e-07 4.90549772233375e-07 420 844 732 1.75382351101527e-08 211 2.12032511377008 2.16279516295948 1 16.0761217358145 418 247 952 732 1748 211 791 455 1887 1387 456 313 M14608 GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. 55/84 Gene Ontology BP GO:0007157 4.06631685904638e-14 1.70455606712998e-12 1005 783.090909090909 732 3.69665169004222e-15 13 3.01344549845267 3.32169299690248 1 42.7863814568307 1004 309 68 13 1757 732 955 181 2390 132 1073 314 M14683 GO_REPLICATIVE_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATIVE_SENESCENCE.html A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. 19/22 Gene Ontology BP GO:0090399 9.97951580752066e-07 1.48924589648472e-06 735 1290 734 9.07229121306832e-08 143 2.67274981072837 2.7578607848733 1 18.7324418154461 734 2167 1885 1855 3078 605 369 143 204 2517 633 315 M11987 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. 28/58 Gene Ontology BP GO:0032715 8.01388814597383e-08 4.02645553947883e-07 140 954.272727272727 736 7.28535312535805e-09 137 2.3779176363126 -2.2232633795951 -1 18.2883071905531 137 2051 1432 1410 736 243 200 383 1744 1714 447 316 M13988 GO_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_PROCESS.html A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 67/119 Gene Ontology BP GO:0022600 7.92878360007489e-09 1.35137839161716e-07 670 824.727272727273 737 7.20798511695471e-10 194 3.14731944887225 -3.04221415332904 -1 26.0437764332288 668 1868 194 673 837 934 398 1027 737 605 1131 317 M15540 GO_CELL_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between cells. 94/122 Gene Ontology BP GO:0007043 1.36677581883468e-07 4.24256696800386e-07 4570 1526.72727272727 737 1.24252354886113e-08 7 2.73678814041649 2.59574101380505 1 20.9887264695156 4570 106 304 7 1398 3453 3889 737 92 633 1605 318 M12635 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS.html Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. 58/80 Gene Ontology BP GO:0050690 3.21053938155426e-07 6.55203497472456e-07 165 1484.72727272727 738 2.91867259098178e-08 111 1.29226749973843 -1.24444346762587 -1 9.56121065406821 111 342 3394 2090 2223 164 161 738 3388 3205 516 319 M16883 GO_POSITIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIOGENESIS.html Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. 52/67 Gene Ontology BP GO:0014015 9.06505134791491e-08 4.02645553947883e-07 1065 920.272727272727 740 8.24095611039851e-09 225 2.36943513672198 -2.0833803986434 -1 18.2227019335143 1062 407 740 225 889 1359 653 2326 626 603 1233 320 M11902 GO_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 100/164 Gene Ontology BP GO:0002028 3.64783246273713e-08 4.02645553947883e-07 4255 1651.90909090909 741 3.31621138474731e-09 49 2.4173108092802 2.56680928346878 1 18.5929814449402 4255 49 225 373 248 3350 4457 1713 741 282 2478 321 M13810 GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS.html Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. 47/71 Gene Ontology BP GO:0021952 1.49707094448743e-07 4.36901586057683e-07 785 903.272727272727 741 1.36097367851012e-08 248 2.57989603301146 2.75718584240219 1 19.739804672545 781 462 661 597 1496 741 2439 377 1028 1106 248 322 M10251 GO_REGULATION_OF_VESICLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_FUSION.html Any process that modulates the frequency, rate or extent of vesicle fusion. 56/71 Gene Ontology BP GO:0031338 1.30800711102628e-07 4.19026589517727e-07 535 1288.63636363636 743 1.18909744435789e-08 360 1.30961542443301 -1.37691741502085 -1 9.99842561851493 532 360 3376 1974 1350 577 633 743 1632 2391 607 323 M11005 GO_APICAL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_ASSEMBLY.html The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. 55/65 Gene Ontology BP GO:0043297 2.38901156546618e-07 5.4517267357107e-07 25 1490.81818181818 744 2.17182893172037e-08 22 2.82712580446891 -3.05034608127722 -1 21.3125739890155 2854 370 730 22 1977 3995 4405 85 22 1195 744 324 M13138 GO_POSITIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of exocytosis. 82/117 Gene Ontology BP GO:0045921 5.25860491278936e-08 4.02645553947883e-07 360 763.909090909091 744 4.7805500349859e-09 154 2.07642517178575 -1.80411608055373 -1 15.9565074162974 356 184 1234 1080 280 154 306 744 1520 1429 1116 325 M16217 GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS.html The process in which the branching structure of the salivary gland is generated and organized. 28/33 Gene Ontology BP GO:0060445 5.36280444453076e-07 9.32130335465133e-07 100 944.454545454545 745 4.87527795617182e-08 61 2.75502515341707 3.17429111771734 1 19.9902641774186 100 745 825 941 3424 380 599 61 1647 1170 497 326 M10819 GO_ACTIN_MYOSIN_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MYOSIN_FILAMENT_SLIDING.html The sliding movement of actin thin filaments and myosin thick filaments past each other. 30/58 Gene Ontology BP GO:0033275 2.711751990521e-07 5.82312367861862e-07 380 964.454545454545 747 2.46522938615959e-08 204 2.97579317170167 3.50929760111027 1 22.3357241749487 379 721 747 1706 2105 972 1657 278 450 1390 204 327 M11385 GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 79/160 Gene Ontology BP GO:0001676 4.47449674751866e-08 4.02645553947883e-07 325 695.272727272727 747 4.06772439865796e-09 177 2.16085709260097 -1.93977927336971 -1 16.6095198695468 322 197 983 1050 177 345 293 1029 1611 747 894 328 M14866 GO_MUSCLE_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FILAMENT_SLIDING.html The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. 30/58 Gene Ontology BP GO:0030049 2.711751990521e-07 5.82312367861862e-07 380 964.909090909091 748 2.46522938615959e-08 205 2.97579317170167 3.50929760111027 1 22.3357241749487 380 722 748 1707 2106 973 1658 272 451 1392 205 329 M11450 GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 814/1070 Gene Ontology BP GO:0051960 9.0784018741742e-24 1.50863585430473e-21 750 1094.45454545455 750 9.07840187417424e-25 15 2.26535421008135 2.48186657676239 1 56.9417526348807 750 1371 4301 303 456 142 1839 1096 1436 15 330 330 M10074 GO_FOREBRAIN_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. 48/71 Gene Ontology BP GO:0021884 1.53448563087655e-06 2.1357946875467e-06 575 1077.36363636364 751 1.39498791015573e-07 122 2.63579942167222 3.09961931635933 1 17.9728687684637 573 456 494 1368 3311 751 1231 122 1774 609 1162 331 M10868 GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 20/20 Gene Ontology BP GO:0090153 3.19616558486666e-08 3.85278716745714e-07 1205 1045.18181818182 752 2.9056051193642e-09 79 2.01515926120888 -1.97251190769542 -1 15.5293311318826 1201 969 2412 822 79 747 752 515 483 3053 464 332 M12887 GO_RESPONSE_TO_INSECTICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSECTICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. 10/22 Gene Ontology BP GO:0017085 5.93687639500759e-07 1.00739663723113e-06 70 898.363636363636 752 5.39716181556537e-08 12 3.48697227131236 3.48697227131236 1 25.1863552536226 68 1209 752 1757 2699 175 12 100 1035 1616 459 333 M11494 GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. 20/20 Gene Ontology BP GO:1905038 3.19616558486666e-08 3.85278716745714e-07 1205 1035.81818181818 753 2.9056051193642e-09 80 2.01515926120888 -1.97251190769542 -1 15.5293311318826 1202 970 2413 823 80 748 753 401 484 3055 465 334 M11618 GO_CRANIAL_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 57/92 Gene Ontology BP GO:0021545 1.17084289671047e-07 4.08625383150012e-07 1070 829 754 1.0644026900208e-08 19 2.42800098347786 2.61761375303942 1 18.6568610564361 1069 333 548 604 1217 768 2434 405 968 754 19 335 M12096 GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 109/202 Gene Ontology BP GO:0030799 4.67310132501238e-08 4.02645553947883e-07 845 1114.27272727273 754 4.24827402206859e-09 75 2.36138475339203 2.47236146286528 1 18.1604387454081 841 75 517 754 196 292 1986 3502 2913 417 764 336 M12174 GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of striated muscle contraction. 91/141 Gene Ontology BP GO:0006942 5.07413395202011e-08 4.02645553947883e-07 755 829 754 4.61284915368289e-09 111 2.47680998915577 2.42475284206504 1 19.0531593615591 754 111 403 874 256 344 2062 1243 1157 477 1438 337 M10720 GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 62/91 Gene Ontology BP GO:0048168 2.26338168309327e-08 3.25046758377561e-07 1560 1183.72727272727 756 2.05761973307196e-09 22 2.40782209051061 2.55651683638631 1 18.7903443901691 1558 304 529 201 22 1745 3582 2140 756 491 1693 338 M14434 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. 26/34 Gene Ontology BP GO:0060045 5.15203566726697e-08 4.02645553947883e-07 1840 878.818181818182 758 4.68366889810828e-09 129 2.63840061188639 2.65024743435183 1 20.3029318167228 1838 686 426 203 264 1215 1002 1244 129 758 1902 339 M12346 GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. 118/127 Gene Ontology BP GO:0006892 8.14097587196228e-08 4.02645553947883e-07 315 1565.54545454545 759 7.40088743019502e-09 295 1.34594766783969 -1.38417838868843 -1 10.3068561672242 313 2828 3964 2524 759 295 435 553 885 4215 450 340 M13843 GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. 5/11 Gene Ontology BP GO:0002676 4.9913301750038e-07 8.85761224420011e-07 765 1208.81818181818 761 4.99133129610612e-08 145 3.62631773086645 -4.04659340574973 -1 26.4420474972471 761 1280 4453 189 2655 750 335 339 145 1162 1228 341 M16346 GO_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGIONALIZATION.html The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 257/438 Gene Ontology BP GO:0003002 6.20732473511259e-08 4.02645553947883e-07 1015 1024 761 5.64302264568453e-09 82 2.14675342099313 2.34167034594402 1 16.5004394043918 1014 1601 549 761 437 82 1596 1757 2417 579 471 342 M10314 GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 17/18 Gene Ontology BP GO:0043517 2.58420085108001e-08 3.51587326317991e-07 285 1651.18181818182 763 2.34927352857725e-09 39 2.30496626723544 2.30496626723544 1 17.8882495966721 284 3328 2450 4470 39 328 99 363 3862 2177 763 343 M16262 GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of cation channel activity. 82/127 Gene Ontology BP GO:2001257 3.96860870180172e-08 4.02645553947883e-07 1750 1036.09090909091 764 3.60782615762906e-09 137 2.40636707288813 2.57869596883532 1 18.5083405167213 1750 150 606 494 137 1464 3243 764 1158 693 938 344 M12161 GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 5/10 Gene Ontology BP GO:0046133 1.61961681602795e-07 4.47244928485344e-07 770 1753.18181818182 766 1.6196169340701e-08 28 3.53595406990509 3.53595406990509 1 27.049681192403 766 2752 4348 3170 4153 526 97 28 203 2616 626 345 M12693 GO_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PAIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 28/52 Gene Ontology BP GO:0048265 7.03024562513566e-08 4.02645553947883e-07 255 952 766 6.39113259071982e-09 14 3.10188474208539 3.69315576971282 1 23.8876057881443 253 2050 486 1738 788 475 1914 14 1786 766 202 346 M15316 GO_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_LOCALIZATION.html A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. 70/79 Gene Ontology BP GO:0031503 4.87647349824764e-08 4.02645553947883e-07 190 1503.09090909091 766 4.43315782394411e-09 22 1.64300523251644 1.61785528996182 1 12.604355586791 189 3193 3153 3436 229 22 89 766 3184 2053 220 347 M10513 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 108/192 Gene Ontology BP GO:1903555 1.36224460236727e-07 4.23928240920297e-07 325 915.454545454545 767 1.2384042606525e-08 73 1.97959852108919 -2.21942131473736 -1 15.1540766236853 323 73 1217 1499 1393 271 767 449 2421 1124 533 348 M12364 GO_NEURAL_CREST_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_MIGRATION.html The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. 51/70 Gene Ontology BP GO:0001755 5.00180025906561e-07 8.86328559668381e-07 400 1245.09090909091 770 4.54709217840732e-08 235 2.43080858924192 2.34582975060699 1 17.6899845592283 398 430 512 2183 2578 770 642 849 2637 235 2462 349 M12687 GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE.html The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. 10/60 Gene Ontology BP GO:0050912 4.25008823014639e-08 4.02645553947883e-07 700 1098.72727272727 770 3.86371664750187e-09 58 2.9537100724351 -3.26309406700942 -1 22.7415948529019 700 2278 1458 1922 163 262 58 639 1684 2152 770 350 M13734 GO_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_BURST.html A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 18/26 Gene Ontology BP GO:0045730 3.03930019766844e-07 6.31051486825133e-07 930 686 772 2.76300056140715e-08 109 2.61446480641764 -2.55182073297075 -1 19.5007834097102 795 927 864 117 2184 772 287 182 109 930 379 351 M16968 GO_HEAD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_MORPHOGENESIS.html The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. 55/69 Gene Ontology BP GO:0060323 4.4837044348119e-07 8.23635086268447e-07 65 1160.09090909091 774 4.07609577146582e-08 61 2.28207051439463 2.60160014167859 1 16.6891882344591 61 371 714 1418 2483 325 1005 2537 2693 774 380 352 M12263 GO_PROXIMAL_DISTAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROXIMAL_DISTAL_PATTERN_FORMATION.html The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). 26/48 Gene Ontology BP GO:0009954 3.22147856721973e-07 6.56526363896802e-07 650 1039 775 2.9286173081306e-08 648 2.5160729339019 2.77240491786191 1 18.7107229156517 648 775 879 768 2226 663 1249 1311 750 1439 721 353 M13402 GO_AMINOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 151/196 Gene Ontology BP GO:0006022 2.67414838766288e-08 3.59618856872699e-07 310 964.454545454545 776 2.43104401833431e-09 219 2.25258252564602 2.51454604678963 1 17.4526499972506 306 1739 219 2159 1101 270 776 619 2296 256 868 354 M13236 GO_RELAXATION_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_MUSCLE.html A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. 28/37 Gene Ontology BP GO:0090075 1.60928341219044e-07 4.4655132638076e-07 510 802.272727272727 778 1.46298502718938e-08 103 2.40410225387043 2.49739467660126 1 18.360135615972 506 726 1025 1305 1588 281 778 1128 903 482 103 355 M13542 GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. 63/94 Gene Ontology BP GO:0050891 2.29585320789922e-09 4.41429957700624e-08 3980 1676.45454545455 782 2.08713928208646e-10 154 3.09400039541542 3.39350523847752 1 27.4190562253121 3977 268 171 299 782 2772 3288 4630 154 457 1643 356 M13278 GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. 16/23 Gene Ontology BP GO:0070233 2.20270628942343e-07 5.17090003367254e-07 800 760.363636363636 790 2.00246046360459e-08 186 2.53493912819836 -2.73879675815801 -1 19.1696682760238 798 1038 1242 210 1914 790 296 265 401 1224 186 357 M14745 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 10/16 Gene Ontology BP GO:0034375 2.15660408982869e-07 5.13521287170422e-07 790 907.272727272727 790 1.96054936475921e-08 72 3.18084864917847 3.56219552868285 1 24.0919571709068 1167 1181 786 72 1880 1524 2055 136 106 790 283 358 M10716 GO_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROPTOTIC_PROCESS.html A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. 33/46 Gene Ontology BP GO:0070266 4.30892555139477e-07 8.02619319080858e-07 180 1040.81818181818 792 3.9172058139475e-08 49 2.48946964850774 -2.46497600086663 -1 18.2490885128985 176 736 1534 2273 2449 210 49 792 889 1764 577 359 M14983 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. 16/18 Gene Ontology BP GO:1902285 4.28806010417095e-07 7.99944739357711e-07 90 1174.81818181818 792 3.89823721814981e-08 53 2.82285786228436 3.18747107377522 1 20.711731991354 88 2165 792 1763 3640 177 128 53 2727 914 476 360 M16477 GO_INNERVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNERVATION.html The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. 26/39 Gene Ontology BP GO:0060384 1.42743617206674e-06 2.00309270437226e-06 525 1134.54545454545 793 1.2976700893069e-07 123 3.08909175991435 3.27131896086891 1 21.1855415574562 523 793 387 880 3283 720 1806 123 1390 355 2220 361 M15552 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 89/127 Gene Ontology BP GO:0051279 1.52549464976127e-07 4.38697565224918e-07 1150 1037.54545454545 797 1.38681341412736e-08 117 2.22035308461248 2.24968225884863 1 16.9696667443241 1146 117 598 498 1522 385 2043 2379 1376 797 552 362 M12766 GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION.html The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 162/271 Gene Ontology BP GO:0009952 5.94132702568038e-08 4.02645553947883e-07 755 1282 799 5.40120653284731e-09 233 2.12844091039443 2.36285573857417 1 16.3588069820123 1228 1735 753 751 395 233 2077 2899 2529 799 703 363 M13499 GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 29/37 Gene Ontology BP GO:0061037 3.25439823795019e-07 6.61542813507306e-07 580 1037.18181818182 799 2.95854429033117e-08 43 2.62839009268637 3.06755604558435 1 19.5400547782636 579 799 1062 2017 2233 320 783 204 1835 1534 43 364 M15095 GO_RESPIRATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_DEVELOPMENT.html The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. 227/307 Gene Ontology BP GO:0060541 5.19809507679438e-08 4.02645553947883e-07 2195 1363.54545454545 799 4.72554109055767e-09 76 2.22511470795138 2.3253296166937 1 17.1065004266013 2194 1620 281 76 268 799 3471 3443 2004 199 644 365 M15603 GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. 22/24 Gene Ontology BP GO:0070861 5.1951297617214e-06 6.43581969682899e-06 355 1559.81818181818 805 4.72285639059899e-07 81 1.4662120967196 -1.39552531940838 -1 9.10259720257918 352 2602 3210 1593 3732 805 81 751 510 3270 252 366 M13772 GO_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within an organism or cell. 70/109 Gene Ontology BP GO:0030104 9.21811875925144e-11 2.35669816410972e-09 3825 1624.27272727273 806 8.38010796330697e-12 125 3.04407957516746 3.26287977857948 1 31.6599202329771 3825 200 126 293 806 2688 3490 4109 125 406 1799 367 M10160 GO_CERAMIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. 11/13 Gene Ontology BP GO:0046514 1.98492033784097e-07 4.93246485651519e-07 465 1362.54545454545 807 1.80447319720705e-08 112 1.73472569757677 -1.79572606788 -1 13.1288214209959 464 2251 2990 3187 1792 418 112 270 807 2373 324 368 M12542 GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of glial cell proliferation. 26/29 Gene Ontology BP GO:0060251 1.21670160677043e-07 4.13234494620643e-07 675 1052.72727272727 807 1.10609243096332e-08 334 1.80765108051896 -1.88471140860431 -1 13.8531116151206 672 805 1968 1204 1254 807 334 590 2003 1177 766 369 M10519 GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 24/54 Gene Ontology BP GO:0030800 1.80295577217211e-07 4.72066258868601e-07 1615 1077.36363636364 808 1.63905083629902e-08 66 3.03438087665932 3.041801673604 1 23.1120100657267 1611 808 487 66 1693 913 1221 2897 692 748 715 370 M12373 GO_GLYCOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 11/13 Gene Ontology BP GO:0019377 1.98492033784097e-07 4.93246485651519e-07 465 1368.18181818182 808 1.80447319720705e-08 113 1.73472569757677 -1.79572606788 -1 13.1288214209959 465 2252 2991 3188 1793 419 113 317 808 2379 325 371 M12564 GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS.html The cellular component assembly that is part of the initial shaping of the component during its developmental progression. 274/381 Gene Ontology BP GO:0010927 2.93771437214389e-08 3.74023910244642e-07 450 971.636363636364 809 2.67064946488356e-09 60 2.149248123512 2.16467471080166 1 16.6029725365077 449 2353 878 2639 60 272 511 491 1213 1013 809 372 M14875 GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune effector process. 147/270 Gene Ontology BP GO:0002699 5.13195659438176e-07 9.00075161464694e-07 95 1254.90909090909 809 4.66541617410685e-08 93 1.79587419978741 -1.79983134539622 -1 13.0278981931057 93 1763 1567 1581 2607 260 317 809 3365 705 737 373 M12810 GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION.html Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 19/20 Gene Ontology BP GO:0090129 1.46563001953196e-07 4.35199520158406e-07 675 1088.27272727273 810 1.33239101561053e-08 20 2.37089285253773 2.19363158201004 1 18.1371586261831 671 968 1608 789 3107 761 1183 20 330 1724 810 374 M13972 GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. 12/26 Gene Ontology BP GO:0045073 2.23997973458729e-06 2.98044772806252e-06 145 1341.27272727273 810 2.03634728661504e-07 13 2.32669264598025 -2.32669264598025 -1 15.4458388156521 142 2256 1825 810 3768 110 13 132 3458 2087 153 375 M10067 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. 132/164 Gene Ontology BP GO:0050680 2.35264479000979e-07 5.3972042302237e-07 540 977.909090909091 813 2.13876821963445e-08 424 2.1016217155439 2.46245292150908 1 15.827961782633 537 1803 813 912 1964 424 1215 694 1153 674 568 376 M10490 GO_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 75/113 Gene Ontology BP GO:0001656 3.47107492836767e-08 3.99952679980378e-07 1100 1077.81818181818 813 3.15552271193904e-09 206 2.85749895870619 3.41812323098572 1 22.0075512696489 1096 206 221 400 1247 813 2362 3029 752 323 1407 377 M10301 GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 362/507 Gene Ontology BP GO:0010721 8.94717751903906e-14 3.52806923695667e-12 1345 954.454545454545 815 8.13379774458127e-15 70 2.35982933491144 2.63423067766447 1 32.5820429230467 1342 1519 70 431 815 534 2289 1625 1036 152 686 378 M13801 GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 562/821 Gene Ontology BP GO:0000904 1.54087913675471e-22 2.10873841862343e-20 820 1201 817 1.54087913675471e-23 18 2.39088741483534 2.64452254385488 1 56.7907775702734 817 1412 4450 288 393 578 2754 920 1040 18 541 379 M12167 GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 135/200 Gene Ontology BP GO:0002221 3.42702237126237e-07 6.84715782949634e-07 240 1028.45454545455 818 3.11547536827508e-08 236 2.1643803782131 -2.33070651709387 -1 16.0331849194274 236 1802 922 723 2272 558 422 818 1498 1256 806 380 M12944 GO_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MORPHOGENESIS.html The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. 73/93 Gene Ontology BP GO:0048813 5.84103636985423e-08 4.02645553947883e-07 1400 1011.54545454545 818 5.31003320448609e-09 233 2.27207236827188 2.58493239966349 1 17.4696798576586 1400 233 818 596 385 1660 3120 394 1004 510 1007 381 M13541 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 101/147 Gene Ontology BP GO:0010522 1.37239873573515e-07 4.24585858868063e-07 1350 1085.45454545455 819 1.24763529213437e-08 69 2.18815532102321 2.21268804528631 1 16.7596707205382 1349 69 539 516 1402 408 2018 2555 1694 571 819 382 M10559 GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cation channel activity. 39/56 Gene Ontology BP GO:2001259 8.84704734183444e-08 4.02645553947883e-07 720 923.545454545455 822 8.04277063418938e-09 222 2.58112876114923 2.79537188211608 1 19.8599804851541 717 536 881 2176 860 666 1855 222 863 822 561 383 M14234 GO_NEGATIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GROWTH.html Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. 244/323 Gene Ontology BP GO:0045926 8.29601683331379e-08 4.02645553947883e-07 825 1010.36363636364 822 7.54183376922701e-09 189 2.08406836368395 2.33493640896231 1 16.0156213088147 822 1613 821 1745 783 189 1409 1173 1388 779 392 384 M14978 GO_REGULATION_OF_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUTAMATE_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of glutamate. 10/26 Gene Ontology BP GO:0014048 6.31268073774627e-08 4.02645553947883e-07 1565 946.272727272727 823 5.73880083534761e-09 94 3.77163990272806 3.45751755906757 1 29.0676189431798 1564 1180 823 469 446 1711 1838 309 94 1621 354 385 M14269 GO_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 43/53 Gene Ontology BP GO:0033280 8.56704593488565e-08 4.02645553947883e-07 2625 1437.72727272727 826 7.7882238804509e-09 61 2.97973616944733 -3.12612863380853 -1 22.9428856123016 2623 512 348 61 826 2289 1296 3826 382 679 2973 386 M11777 GO_SYNAPTIC_VESICLE_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_RECYCLING.html The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. 28/39 Gene Ontology BP GO:0036465 6.64266081290141e-08 4.02645553947883e-07 1375 1213.36363636364 829 6.03878273951758e-09 362 1.67323733911492 -1.60893624551105 -1 12.8381764202643 1375 800 2631 1791 504 829 533 885 596 3041 362 387 M15143 GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 70/102 Gene Ontology BP GO:0060193 2.71195121675619e-07 5.82312367861862e-07 560 1166.63636363636 831 2.46541050096351e-08 247 2.50643946597261 -2.78008575596136 -1 18.7966077348571 831 1866 556 1158 2107 706 1146 247 2841 559 816 388 M16818 GO_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_CIRCULATION.html Any process that modulates the frequency, rate or extent of blood circulation. 275/435 Gene Ontology BP GO:1903522 6.58095458655974e-24 1.13411784041713e-21 780 1018 832 5.98268598778156e-25 13 2.63493696864537 2.81393122475043 1 66.6432648418371 778 1557 13 832 746 326 2039 2239 1788 33 847 389 M10034 GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. 16/22 Gene Ontology BP GO:0042053 3.9941317018841e-07 7.56705814693271e-07 740 1118.36363636364 833 3.63102947911332e-08 408 2.46079665372471 2.33413698325276 1 18.1138506293601 736 1031 1162 1742 2407 833 696 408 766 1990 531 390 M15930 GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. 16/22 Gene Ontology BP GO:0042069 3.9941317018841e-07 7.56705814693271e-07 740 1116.18181818182 834 3.63102947911332e-08 370 2.46079665372471 2.33413698325276 1 18.1138506293601 737 1032 1163 1743 2408 834 697 370 767 1995 532 391 M11393 GO_NEURAL_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. 193/237 Gene Ontology BP GO:0021915 5.2554277975088e-08 4.02645553947883e-07 370 857.363636363636 838 4.77766174822917e-09 115 2.03942427021888 2.16468319138651 1 15.6703354416303 370 1667 838 927 279 115 1151 1681 1517 411 475 392 M16638 GO_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. 64/88 Gene Ontology BP GO:0055072 5.40885799682982e-08 4.02645553947883e-07 410 1490.18181818182 841 4.91714375437315e-09 183 1.57844904037151 -1.64558139809563 -1 12.1050657803057 410 2466 3079 3678 313 199 183 841 1937 2610 676 393 M12079 GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. 23/37 Gene Ontology BP GO:0030320 1.10495140611741e-07 4.02645553947883e-07 2165 1186.18181818182 844 1.0045013287397e-08 393 2.88813260708637 2.68082368243112 1 22.2344063261956 2164 832 675 407 1154 1897 2275 1605 393 844 802 394 M15677 GO_GANGLION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLION_DEVELOPMENT.html The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. 19/27 Gene Ontology BP GO:0061548 2.13025463675748e-06 2.8515750359127e-06 235 1238.81818181818 844 1.93659699952786e-07 129 2.70018819319622 2.78518108125945 1 18.0045196148506 232 958 844 2217 3634 362 303 129 3114 1074 760 395 M10256 GO_CARBOHYDRATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORT.html The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. 85/126 Gene Ontology BP GO:0008643 2.65858505128258e-07 5.75100736858827e-07 1035 843.090909090909 845 2.41689579323522e-08 173 2.33219055423823 -2.23976903922209 -1 17.4979656327386 1034 173 845 1251 2090 729 963 239 371 1304 275 396 M13241 GO_CELLULAR_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions at the level of a cell. 23/37 Gene Ontology BP GO:0030002 1.10495140611741e-07 4.02645553947883e-07 2165 1168.63636363636 845 1.0045013287397e-08 394 2.88813260708637 2.68082368243112 1 22.2344063261956 2165 833 676 408 1155 1898 2276 1402 394 845 803 397 M14871 GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. 39/42 Gene Ontology BP GO:0045839 8.69661264640101e-08 4.02645553947883e-07 250 1306.18181818182 845 7.9060118092533e-09 184 1.79823838847442 1.95942656807776 1 13.8049581908656 457 3223 2817 2534 845 248 184 246 897 2469 448 398 M10832 GO_ADULT_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_BEHAVIOR.html Behavior in a fully developed and mature organism. 130/246 Gene Ontology BP GO:0030534 3.31735072719034e-09 6.05318938573203e-08 1430 1142.90909090909 846 3.01577339290231e-10 181 2.56298391844925 2.95285670769042 1 22.2704797288367 1426 1788 181 409 1642 1251 3841 601 846 352 235 399 M11487 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. 97/102 Gene Ontology BP GO:0000070 1.2951920173901e-07 4.18739690741189e-07 120 934.090909090909 846 1.17744735785557e-08 100 1.77155497047955 2.07567920573787 1 13.5621153865528 120 100 2237 1907 1332 368 244 846 991 1295 835 400 M14026 GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT.html The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. 1226/1793 Gene Ontology BP GO:0006928 1.04981966660526e-27 5.42756767634918e-25 785 1237.90909090909 848 1.04981966660526e-28 8 2.33795227366228 2.50544833506612 1 68.5077677580435 784 1321 4467 277 359 509 2389 848 1738 8 917 401 M14292 GO_NEUTRAL_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. 71/116 Gene Ontology BP GO:0006638 8.7193439675519e-08 4.02645553947883e-07 525 1265.45454545455 848 7.92667664829909e-09 231 1.98198543492366 -1.97992205403227 -1 15.2260926198899 525 2451 1692 2656 848 231 410 450 2424 1705 528 402 M11055 GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. 25/34 Gene Ontology BP GO:0002042 1.1722479241734e-07 4.08625383150012e-07 40 923.181818181818 849 1.06567998785042e-08 3 2.71841984269039 2.91452826726451 1 20.9007667336521 40 2071 901 1858 2652 59 30 16 1676 849 3 403 M11196 GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. 45/50 Gene Ontology BP GO:0046825 9.13296730152303e-07 1.39467334604485e-06 750 1976.81818181818 850 8.30270099358045e-08 332 1.91118761395525 2.13214455970575 1 13.431421919658 747 4183 3244 3323 3009 723 619 850 736 3979 332 404 M13923 GO_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. 25/54 Gene Ontology BP GO:0055078 8.12816051222538e-08 4.02645553947883e-07 3775 1738.54545454545 850 7.3892371022999e-09 348 3.01040876805342 -3.21710766007189 -1 23.1801132943192 3771 765 531 447 757 3981 4064 2175 348 850 1435 405 M16015 GO_AMINOGLYCAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 58/79 Gene Ontology BP GO:0006026 1.00469420331794e-07 4.02645553947883e-07 580 1158.18181818182 852 9.13358408363848e-09 331 2.14870592952771 2.65023557832754 1 16.5155404748856 580 331 1134 3128 1010 582 852 815 2535 1092 681 406 M14509 GO_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. 47/82 Gene Ontology BP GO:0046530 3.55949922522057e-07 6.99719049216364e-07 2335 1361 853 3.23590891011943e-08 173 2.60776599777378 3.06889914266512 1 19.3090773603663 2333 466 608 1289 2311 2066 3519 173 853 668 685 407 M11905 GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 70/125 Gene Ontology BP GO:1903557 1.37867440236786e-07 4.24835370983751e-07 530 1188.27272727273 854 1.25334044433208e-08 251 1.82898968739516 -1.89541771629198 -1 13.9912604867306 251 260 1616 2417 1404 528 854 530 3254 1120 837 408 M12492 GO_ARTERY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_MORPHOGENESIS.html The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. 76/97 Gene Ontology BP GO:0048844 5.16966826461534e-10 1.12404048762875e-08 280 1212.27272727273 854 4.69969842348195e-11 146 3.00210066641684 3.20421823941113 1 28.7585270359295 276 1852 146 168 3514 836 2374 2007 854 295 1013 409 M15065 GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 25/32 Gene Ontology BP GO:0050995 7.11725103379142e-08 4.02645553947883e-07 2025 1257.54545454545 854 6.47022842185692e-09 223 2.27481712904334 -2.83787476881668 -1 17.4909083568761 2025 854 1862 223 583 2142 1966 704 284 2633 557 410 M12344 GO_NEPHRIC_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. 20/29 Gene Ontology BP GO:0072176 3.18459294095132e-07 6.50478970774648e-07 215 895.909090909091 855 2.89508491084972e-08 214 2.39195920820434 2.72898204998377 1 17.7943011120779 214 937 1396 1007 2220 622 593 338 855 1216 457 411 M11740 GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 306/414 Gene Ontology BP GO:0051961 1.21640004552441e-10 3.02668952504014e-09 860 737.181818181818 856 1.10581822326515e-11 130 2.34336535726065 2.71993310257603 1 24.0404889784949 856 1546 130 490 958 168 1492 944 1114 262 149 412 M11315 GO_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGENERATION.html The regrowth of a lost or destroyed body part, such as an organ or tissue. 177/245 Gene Ontology BP GO:0031099 6.81351240104075e-08 4.02645553947883e-07 1390 971.727272727273 858 6.19410237459882e-09 39 2.30642358439669 2.27523392026315 1 17.7353586636976 1387 1696 303 39 535 310 1254 2059 858 515 1733 413 M13653 GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. 25/31 Gene Ontology BP GO:0045879 1.08072441542343e-07 4.02645553947883e-07 385 917.545454545455 859 9.82476789557063e-09 194 2.31915891603894 2.25072329669712 1 17.8338561286179 383 810 1296 1731 1116 337 194 782 1284 1301 859 414 M14783 GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. 25/31 Gene Ontology BP GO:0034394 7.61547208096847e-08 4.02645553947883e-07 885 1109.54545454545 860 6.92315667689455e-09 52 2.08180181458427 2.29397747093629 1 15.9980913891622 885 823 1492 860 662 1421 2715 305 52 2632 358 415 M15229 GO_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. 991/1348 Gene Ontology BP GO:0030030 5.18200855067021e-11 1.36999351058344e-09 860 1222.63636363636 860 5.18200855079104e-12 99 2.12363135104712 2.30076432209507 1 22.6607331249806 860 1343 4542 317 331 806 1918 623 1371 99 1239 416 M14345 GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. 26/42 Gene Ontology BP GO:0055083 1.70691887294029e-07 4.59245216956312e-07 1625 1085.27272727273 861 1.55174455034127e-08 415 2.9348739827118 2.78462717180182 1 22.3931634434738 1624 754 565 415 1646 1823 2051 983 459 757 861 417 M16129 GO_NEGATIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXONOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. 83/105 Gene Ontology BP GO:0050771 1.11456581449575e-07 4.02645553947883e-07 945 848.272727272727 862 1.01324170087453e-08 163 2.3838143931595 2.77503390481449 1 18.3339138238931 944 163 586 909 1169 862 2206 211 1064 827 390 418 M10429 GO_SINGLE_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BEHAVIOR.html The specific behavior of a single organism in response to external or internal stimuli. 395/632 Gene Ontology BP GO:0044708 3.87469162561419e-11 1.07315119845136e-09 1480 1088.72727272727 863 3.52244693243857e-12 115 2.28073829277587 2.59300627477403 1 24.6373390842339 1478 1504 115 863 1075 667 3141 585 1678 241 629 419 M11817 GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 20/33 Gene Ontology BP GO:0061217 6.05169971380044e-08 4.02645553947883e-07 410 1612.54545454545 863 5.50154534569904e-09 95 2.59684860698067 2.34307477225043 1 19.9815607475948 2737 863 721 95 410 2378 2355 4607 409 403 2760 420 M12838 GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 142/173 Gene Ontology BP GO:0010594 6.74818063289075e-08 4.02645553947883e-07 865 972.363636363636 863 6.13470985443762e-09 198 2.15229349556826 2.1389937076385 1 16.5432873895443 863 1775 701 198 523 361 1358 1724 1267 847 1079 421 M14991 GO_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 177/261 Gene Ontology BP GO:0050920 3.48470654291501e-12 1.11823031339197e-10 855 1141 865 3.16791503901867e-13 95 2.46768274124255 2.50921640960081 1 29.5962945532606 852 1704 95 865 853 815 1867 1007 2573 140 1780 422 M16461 GO_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIOR.html The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 512/825 Gene Ontology BP GO:0007610 1.57109648009497e-10 3.82738844077586e-09 1195 1320.45454545455 866 1.57109648020604e-11 109 2.32351769734888 2.61611538474186 1 23.5495584900795 1193 1440 4625 338 866 372 2717 836 1448 109 581 423 M15376 GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT.html The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis. 30/38 Gene Ontology BP GO:0090662 8.08563443814111e-08 4.02645553947883e-07 320 1206.36363636364 867 7.35057703210138e-09 120 1.65221283498851 -1.79254623966712 -1 12.6755689267313 316 744 2453 1940 750 981 679 120 1465 2955 867 424 M14739 GO_HINDBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_MORPHOGENESIS.html The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. 57/80 Gene Ontology BP GO:0021575 7.21448385071704e-08 4.02645553947883e-07 1495 990 868 6.55862189754762e-09 175 2.51840810512941 2.58346447209465 1 19.3748870624123 1493 390 829 175 602 898 868 2461 1691 877 606 425 M14976 GO_FEMALE_MEIOTIC_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_MEIOTIC_DIVISION.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. 24/32 Gene Ontology BP GO:0007143 1.43804183882495e-07 4.2919876049086e-07 55 1001.36363636364 868 1.30731084802122e-08 39 1.98366587704075 2.12182603018612 1 15.1725507739895 51 868 1726 2208 1460 91 39 297 1406 2164 705 426 M15636 GO_CELLULAR_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 52/58 Gene Ontology BP GO:0071295 2.07747972118323e-12 7.00471966859823e-11 855 1555.18181818182 868 1.88861792835017e-13 88 3.25734504247591 3.26503950676602 1 39.900357986028 854 377 88 868 3362 1793 4128 2786 733 220 1898 427 M13415 GO_BLOOD_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. 412/539 Gene Ontology BP GO:0048514 1.20808739821601e-21 1.47927122734186e-19 600 999.545454545455 869 1.09826127110546e-22 18 2.52541346259732 2.65819177634776 1 57.4080156167576 598 1496 18 675 1542 510 2083 1116 2034 54 869 428 M14064 GO_RETINA_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_LAYER_FORMATION.html The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. 30/38 Gene Ontology BP GO:0010842 2.13125949941356e-07 5.11172703648005e-07 3255 1550.45454545455 872 1.93750882352752e-08 72 2.5589110092011 2.98970376050168 1 19.3673906256959 3252 660 771 861 1868 4151 3166 72 226 1156 872 429 M15295 GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION.html The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. 55/73 Gene Ontology BP GO:0006929 8.95031793440383e-08 4.02645553947883e-07 490 759.454545454545 872 8.13665299866545e-09 107 2.72801778964696 3.37698388454107 1 20.9960480284314 488 357 453 931 872 635 1172 107 1365 1027 947 430 M10438 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 17/40 Gene Ontology BP GO:0046189 5.67810642727143e-07 9.75636233607606e-07 1700 997.090909090909 874 5.16191626615188e-08 64 2.5800707374587 -2.49497514719626 -1 18.6524515825754 1696 941 668 64 2665 1541 874 275 339 590 1315 431 M10670 GO_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_PRIMARY_GERM_LAYER.html The formation of the ectoderm, mesoderm and endoderm during gastrulation. 128/178 Gene Ontology BP GO:0001704 8.97933892727268e-08 4.02645553947883e-07 195 1092.81818181818 876 8.16303572160544e-09 191 2.18750374545399 2.41717743954183 1 16.8156101252514 191 1800 300 1294 876 389 1510 2225 2298 631 507 432 M15506 GO_CEREBRAL_CORTEX_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_CELL_MIGRATION.html The orderly movement of cells from one site to another in the cerebral cortex. 51/66 Gene Ontology BP GO:0021795 5.40993810984352e-08 4.02645553947883e-07 880 782.545454545455 876 4.918125675343e-09 109 2.27216982823309 2.59218690111796 1 17.4704336314417 880 378 697 599 314 923 1372 109 876 1251 1209 433 M12137 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 27/30 Gene Ontology BP GO:0051985 2.55863992857266e-06 3.3545651134541e-06 155 1509.27272727273 879 2.32603900392926e-07 111 1.66985893084109 1.82054581290399 1 10.9526454925648 152 2939 2878 2457 3518 257 111 273 879 2914 224 434 M12652 GO_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT.html The directed movement of calcium ions into a cell or organelle. 61/111 Gene Ontology BP GO:0070509 3.81194856243072e-08 4.02645553947883e-07 1110 1065 879 3.46540784407319e-09 125 2.33042419955884 2.71351468034588 1 17.9209839631721 1106 297 639 879 125 1047 2414 1291 2357 865 695 435 M13260 GO_APPENDAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APPENDAGE_DEVELOPMENT.html The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. 209/288 Gene Ontology BP GO:0048736 1.61282405373305e-07 4.4655132638076e-07 265 946.272727272727 881 1.46620379269953e-08 137 2.26482340080432 2.54614065011565 1 17.2904978870487 264 1647 410 602 1592 186 1626 1020 2044 881 137 436 M16165 GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. 42/59 Gene Ontology BP GO:0046622 5.0544438342621e-08 4.02645553947883e-07 1590 981 882 4.59494904580607e-09 150 2.36638211757215 2.25804733621547 1 18.1990893056646 1589 461 546 150 254 986 882 2170 181 891 2681 437 M16176 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition. 36/44 Gene Ontology BP GO:1902808 4.33804511395944e-06 5.45243757840445e-06 820 1872.09090909091 882 3.94368515264385e-07 302 2.20490411351368 2.37084707231817 1 13.932476668521 820 3711 2926 3059 3678 454 302 800 882 3512 449 438 M11270 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. 41/62 Gene Ontology BP GO:0086004 5.89733666711657e-08 4.02645553947883e-07 1850 1269.90909090909 884 5.36121529563731e-09 319 2.62163900197217 2.8221221670392 1 20.1732943537253 1846 1924 650 884 392 1838 2757 719 319 566 2074 439 M12969 GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. 28/34 Gene Ontology BP GO:0030201 9.00455511386464e-08 4.02645553947883e-07 795 937.636363636364 885 8.18595952947205e-09 162 2.30045620805418 2.16163424284129 1 17.6892058458148 794 739 1059 1702 885 966 1345 162 379 1409 874 440 M12273 GO_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_PAIN.html The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. 71/149 Gene Ontology BP GO:0019233 1.30432726528708e-07 4.18739690741189e-07 2560 1450.90909090909 886 1.1857521296523e-08 263 2.53335346804622 2.65614792432121 1 19.4383271866817 2559 263 476 580 1345 2802 4224 1562 886 443 820 441 M10054 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. 60/82 Gene Ontology BP GO:0030858 1.55702707306016e-06 2.1633545685206e-06 1210 1251 887 1.41548015911904e-07 334 2.20242765489158 -1.84103490899183 -1 14.9860535544012 1210 334 887 2210 3317 734 532 1574 1853 586 524 442 M11471 GO_MANGANESE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_TRANSPORT.html The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/14 Gene Ontology BP GO:0006828 2.59920856123002e-07 5.68867235907963e-07 890 1536.72727272727 887 2.5992088652449e-08 42 2.23736359181364 -2.22116668172507 -1 16.7951182235675 887 2309 4305 2252 2214 625 68 42 599 2934 669 443 M11165 GO_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of exocytosis. 164/250 Gene Ontology BP GO:0017157 9.50675621568117e-08 4.02645553947883e-07 295 822.818181818182 888 8.64250602408381e-09 62 2.010455927942 -1.81652086550937 -1 15.4462888005715 295 1722 1048 888 944 62 295 702 1165 1116 814 444 M10510 GO_CORONARY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORONARY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. 68/93 Gene Ontology BP GO:0060976 4.3978726775536e-07 8.13003638007822e-07 960 1100.09090909091 891 3.99806686973011e-08 155 2.28816156223332 2.80348374135867 1 16.7496220114114 958 283 891 780 2469 1644 2498 155 913 756 754 445 M13500 GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 24/29 Gene Ontology BP GO:0030206 1.05080244859403e-06 1.55070846600318e-06 35 1134.90909090909 891 9.55275409542725e-08 35 2.8978393005803 2.98096383396573 1 20.2571376370961 35 891 944 3136 3116 162 142 376 1102 1798 782 446 M10369 GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoclast differentiation. 79/137 Gene Ontology BP GO:0045670 2.26492796083699e-07 5.25883722643439e-07 375 1322.36363636364 893 2.05902563092203e-08 373 2.66210000814229 -2.92475024001398 -1 20.1128680001533 373 2845 684 760 1938 640 434 893 2690 2347 942 447 M11019 GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein oligomerization. 33/43 Gene Ontology BP GO:0032459 5.60692967657353e-07 9.6483150092813e-07 895 1370.45454545455 894 5.09721009596237e-08 234 3.78314751131357 -3.66837803842103 -1 27.4201530820799 894 3719 1095 735 2662 699 382 903 523 3229 234 448 M16547 GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION.html Any process that modulates the frequency, rate or extent of sister chromatid segregation. 75/81 Gene Ontology BP GO:0033045 1.00180854473016e-06 1.49260811995819e-06 210 1528.54545454545 895 9.10735455383203e-08 209 1.62985356435515 1.80667961476657 1 11.3810139896013 209 1858 3008 2444 3082 420 236 895 784 3051 827 449 M11646 GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM.html The process in which the anatomical structures of embryonic epithelia are generated and organized. 165/203 Gene Ontology BP GO:0016331 7.49999554764819e-08 4.02645553947883e-07 830 1071.63636363636 896 6.81817800302701e-09 205 2.06446818289281 2.32156186803637 1 15.8640298014917 827 1719 896 1321 648 205 1723 1895 1364 556 634 450 M10247 GO_LENS_FIBER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. 28/49 Gene Ontology BP GO:0070306 2.8211994950436e-08 3.68884365916242e-07 4575 1464.90909090909 897 2.56472684656513e-09 51 2.02189798593759 -1.27826782112398 -1 15.6277842676705 4572 768 1766 657 51 2694 1089 709 201 2710 897 451 M11624 GO_RESPONSE_TO_MURAMYL_DIPEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MURAMYL_DIPEPTIDE.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. 20/24 Gene Ontology BP GO:0032495 1.58214438623927e-06 2.19232912121927e-06 355 1250.54545454545 897 1.43831411277263e-07 319 2.02636382066663 -1.78918566220074 -1 13.7656657373896 351 897 1276 1562 3325 856 319 2178 691 542 1759 452 M10038 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION.html The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. 20/46 Gene Ontology BP GO:0050908 3.5076192940557e-08 3.99952679980378e-07 2710 1518.45454545455 899 3.18874486361838e-09 101 2.70587364610328 2.79777126410362 1 20.8343179989343 2706 899 819 114 101 3405 4482 571 298 1494 1814 453 M14231 GO_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/57 Gene Ontology BP GO:0032371 6.63446507406902e-07 1.08889474390276e-06 3020 1750 899 6.03133370436627e-08 199 2.96347618131246 4.12569022111789 1 21.2686052832685 3018 580 889 199 2789 3344 4265 2263 405 899 599 454 M14697 GO_CELLULAR_COMPONENT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MORPHOGENESIS.html The process in which cellular structures, including whole cells or cell parts, are generated and organized. 977/1351 Gene Ontology BP GO:0032989 4.01995829179072e-18 3.17031625961055e-16 900 1214.09090909091 899 4.01995829179073e-19 32 2.24776481532217 2.39911190991719 1 42.0298771744404 897 1341 4512 291 252 472 1766 1653 1240 32 899 455 M14779 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. 20/46 Gene Ontology BP GO:0050962 3.5076192940557e-08 3.99952679980378e-07 2710 1520.36363636364 900 3.18874486361838e-09 102 2.70587364610328 2.79777126410362 1 20.8343179989343 2707 900 820 115 102 3406 4483 578 299 1499 1815 456 M15298 GO_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/57 Gene Ontology BP GO:0032374 6.63446507406902e-07 1.08889474390276e-06 3020 1720.36363636364 900 6.03133370436627e-08 200 2.96347618131246 4.12569022111789 1 21.2686052832685 3019 581 890 200 2790 3345 4266 1927 406 900 600 457 M16504 GO_AUTOPHAGOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. 47/52 Gene Ontology BP GO:1905037 6.23195285449965e-07 1.043250280533e-06 150 1844.09090909091 901 5.66541329075388e-08 120 1.37114060765308 -1.49285416910467 -1 9.8160722224417 150 3691 3572 3902 2737 156 120 901 441 4346 269 458 M16663 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY.html Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. 12/14 Gene Ontology BP GO:2000095 6.41481376685884e-07 1.06676656387399e-06 905 1245.90909090909 901 5.83165057936969e-08 135 2.57808757531085 2.83091241956279 1 18.5171172953213 901 2720 1755 1806 2756 287 135 536 598 1606 605 459 M12672 GO_HIPPOCAMPUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPOCAMPUS_DEVELOPMENT.html The progression of the hippocampus over time from its initial formation until its mature state. 84/129 Gene Ontology BP GO:0021766 6.1645788315456e-07 1.03476858958087e-06 285 1040.72727272727 902 5.60416414446489e-08 166 1.89663886607217 2.16397412177962 1 13.6257349521029 282 196 1698 987 2729 417 902 166 1399 2324 348 460 M13284 GO_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions within an organism or cell. 53/98 Gene Ontology BP GO:0055081 2.55687375581269e-07 5.65745344301423e-07 3045 1613.09090909091 902 2.32443095725139e-08 113 2.53893345022863 2.72753290772005 1 19.0801152863394 3043 392 834 113 2042 2818 4315 2193 501 902 591 461 M16790 GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of organelle assembly. 57/66 Gene Ontology BP GO:1902117 1.47259833846733e-07 4.36155319470942e-07 750 1195.09090909091 902 1.33872585185237e-08 93 1.90348702559841 -1.77370170508859 -1 14.5390471148319 749 369 2123 522 1473 902 476 1633 93 3320 1486 462 M11465 GO_NEURAL_RETINA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_RETINA_DEVELOPMENT.html The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. 52/87 Gene Ontology BP GO:0003407 1.48629741001281e-07 4.36901586057683e-07 3425 1532.81818181818 903 1.35117955493232e-08 355 2.13482177333942 2.56397551308344 1 16.3166036194822 3424 355 903 697 1484 3400 3756 396 570 1149 727 463 M12752 GO_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. 109/141 Gene Ontology BP GO:0060070 9.16652895311626e-08 4.02645553947883e-07 665 903.363636363636 903 8.33320848640841e-09 60 1.98026489578427 2.38998586337189 1 15.2127856445957 663 60 1195 207 903 1163 2530 1000 1078 862 276 464 M13359 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. 156/215 Gene Ontology BP GO:0051092 8.98317673371783e-08 4.02645553947883e-07 480 1218.81818181818 904 8.16652463684047e-09 477 2.08339594038197 -2.2831070933528 -1 16.0104206597496 477 2382 1292 1148 877 536 618 904 3408 1190 575 465 M14544 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. 151/288 Gene Ontology BP GO:0002703 3.29666198985717e-07 6.66639210726007e-07 460 1405.18181818182 906 2.99696589441489e-08 426 1.80109541417603 -1.67917031166604 -1 13.3500902266238 460 1753 1662 2019 2245 426 785 747 3728 906 726 466 M16704 GO_METAPHASE_PLATE_CONGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAPHASE_PLATE_CONGRESSION.html The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. 51/51 Gene Ontology BP GO:0051310 7.8520551511462e-08 4.02645553947883e-07 610 1173 906 7.13823221035925e-09 279 1.67634615744167 2.06863832893965 1 12.8622206095077 610 424 2593 1978 702 653 279 1124 906 2623 1011 467 M15991 GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of autophagosome assembly. 41/43 Gene Ontology BP GO:2000785 9.20529761260319e-08 4.02645553947883e-07 980 1570.63636363636 907 8.3684527252488e-09 4 1.15671664768301 -1.08907646405975 -1 8.8433076477745 977 606 3554 2783 907 293 543 712 2650 4248 4 468 M16721 GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. 19/30 Gene Ontology BP GO:0090025 3.50081117758487e-07 6.94934915072628e-07 1120 1039.81818181818 907 3.18255612241937e-08 317 3.15154374831174 3.19560562928625 1 23.3682789783007 1119 907 396 477 2287 1365 1870 622 317 465 1613 469 M13536 GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. 42/46 Gene Ontology BP GO:0070830 1.22447862647099e-07 4.14338946095474e-07 1205 937.727272727273 908 1.11316244965743e-08 25 2.65403123571913 -3.0816632563026 -1 20.3839153297678 1205 516 908 25 1259 1940 2986 104 43 1058 271 470 M15288 GO_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_BEHAVIOR.html The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. 194/330 Gene Ontology BP GO:0007626 1.18396373830841e-11 3.55463316326451e-10 355 970.363636363636 909 1.07633067119526e-12 103 2.39374908511769 2.76535191505286 1 27.2524325241676 1471 1641 103 352 353 1066 3049 991 909 188 551 471 M16868 GO_CELLULAR_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 37/52 Gene Ontology BP GO:0071312 9.08282062970671e-08 4.02645553947883e-07 2345 1357.27272727273 909 8.25711000426905e-09 141 2.94115606484223 3.30076004200925 1 22.6444997824927 2341 594 530 141 892 1992 3304 2398 1265 564 909 472 M12440 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD.html The morphogenetic process in which an epithelial sheet bends along a linear axis. 20/25 Gene Ontology BP GO:0060571 2.29968996543168e-07 5.31831879182586e-07 1000 991.545454545455 910 2.09062745983767e-08 364 2.81080538335205 2.90168758537887 1 21.2255228462968 998 910 816 652 1949 494 399 1682 364 945 1698 473 M12044 GO_HISTONE_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_EXCHANGE.html The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. 45/164 Gene Ontology BP GO:0043486 2.78112909046019e-07 5.93333042545222e-07 25 1226.81818181818 911 2.52829949276052e-08 25 1.64303101854914 1.80974488822482 1 12.2699796270697 25 508 2581 2840 2123 174 53 911 1920 1514 846 474 M14968 GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a humoral immune response. 38/65 Gene Ontology BP GO:0002920 9.75665213441138e-08 4.02645553947883e-07 395 1506.45454545455 911 8.86968415191229e-09 109 2.97619270248366 -3.17476226668103 -1 22.9154797682485 395 3497 911 2374 977 634 654 439 3944 2637 109 475 M12628 GO_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CONTRACTION.html A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. 219/347 Gene Ontology BP GO:0006936 3.33609982837056e-15 1.65136941504343e-13 1125 980.272727272727 912 3.03281802579141e-16 55 2.55839504715808 2.82532254113252 1 39.4465170339538 1124 1611 55 316 222 1049 3477 912 949 166 902 476 M15312 GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 30/34 Gene Ontology BP GO:0090181 3.88850627784996e-07 7.45190268156336e-07 915 1597.81818181818 913 3.53500633194975e-08 305 1.56092198294209 -1.35909600610997 -1 11.4648224058726 913 2555 3017 1628 2380 824 305 658 895 3489 912 477 M10849 GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. 21/53 Gene Ontology BP GO:0002701 1.41647316348302e-07 4.2854237685504e-07 1190 876.909090909091 914 1.2877029588026e-08 225 2.47443280055672 -2.9186029241721 -1 18.9537622069127 482 914 1187 734 1434 1118 1188 225 1010 834 520 478 M13691 GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that modulates the frequency, rate or extent of regulated secretory pathway. 117/188 Gene Ontology BP GO:1903305 1.39317556617533e-07 4.25357343137389e-07 915 909.272727272727 915 1.26652332218164e-08 30 2.11698714478733 -1.95237050854562 -1 16.20920732304 915 30 955 510 1421 445 631 1215 1489 722 1669 479 M12476 GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. 10/12 Gene Ontology BP GO:0006677 9.53661831504858e-06 1.12824523315335e-05 295 1327.27272727273 916 8.6696905953503e-07 1 2.36054726373482 -2.36054726373482 -1 14.0216365261453 294 2263 2536 916 3906 553 224 285 1 2689 933 480 M14474 GO_DETECTION_OF_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_ABIOTIC_STIMULUS.html The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. 128/227 Gene Ontology BP GO:0009582 2.52831486602835e-08 3.44992641396772e-07 805 1084.63636363636 916 2.29846808644055e-09 138 2.49627237133977 2.57945641485444 1 19.4062984900427 802 1806 218 138 1262 916 3536 1490 1101 259 403 481 M10308 GO_BODY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_MORPHOGENESIS.html The process in which the anatomical structures of the soma are generated and organized. 62/79 Gene Ontology BP GO:0010171 3.57098012103321e-07 7.01383305325772e-07 65 1251.72727272727 919 3.24634609151374e-08 64 2.20262766609617 2.5195265483468 1 16.2905064277008 64 326 919 1428 2313 459 1334 2486 2911 909 620 482 M16683 GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 18/30 Gene Ontology BP GO:0061213 8.99048429458578e-08 4.02645553947883e-07 2115 1311.90909090909 919 8.1731678745359e-09 96 2.52447752649849 2.34307477225043 1 19.4218291158413 2115 919 801 96 881 2318 2542 2704 437 375 1243 483 M10663 GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. 23/30 Gene Ontology BP GO:0006656 2.29352955324899e-06 3.03953090608589e-06 925 1388.45454545455 921 2.08502904026168e-07 223 1.8064111466235 -1.67480497034554 -1 11.9502827817212 921 2077 2357 2362 3476 517 223 390 345 2354 251 484 M16087 GO_SOMITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITE_DEVELOPMENT.html The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 86/123 Gene Ontology BP GO:0061053 8.50987982092197e-08 4.02645553947883e-07 1380 1106.63636363636 921 7.73625468190448e-09 153 2.16719606641978 2.69328976657842 1 16.6585466926315 1376 153 907 214 809 746 2327 1882 1861 977 921 485 M12585 GO_CEREBELLAR_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 62/95 Gene Ontology BP GO:0021695 1.34942362678053e-07 4.23104321793113e-07 1460 942.272727272727 925 1.22674882686429e-08 112 2.62311487468425 2.81310726477918 1 20.1164247939036 1457 325 705 112 1382 858 925 1443 1192 1215 751 486 M10682 GO_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CYCLE.html The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. 98/143 Gene Ontology BP GO:0042633 6.16473419291448e-08 4.02645553947883e-07 1255 859.909090909091 927 5.60430396878153e-09 76 2.72690171468533 3.33996908891198 1 20.9874160934752 1254 76 234 441 1426 927 1629 1067 667 414 1324 487 M13786 GO_REGULATION_OF_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. 26/38 Gene Ontology BP GO:0030823 6.50412295688791e-08 4.02645553947883e-07 1120 1501 928 5.91283922652464e-09 469 2.28809511362554 2.1077541560702 1 17.5936028023241 1120 801 928 766 483 740 1456 4052 3646 469 2050 488 M13884 GO_MOLTING_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLTING_CYCLE.html The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. 98/143 Gene Ontology BP GO:0042303 6.16473419291448e-08 4.02645553947883e-07 1255 881 928 5.60430396878153e-09 77 2.72690171468533 3.33996908891198 1 20.9874160934752 1255 77 235 442 1427 928 1630 1289 668 415 1325 489 M12156 GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication. 10/13 Gene Ontology BP GO:2000105 8.86725374125613e-06 1.05387820327113e-05 935 1625.09090909091 931 8.0611722559488e-07 258 1.51190930420493 1.84790001642444 1 8.99786540360483 931 2275 2743 2062 3889 865 258 389 568 3190 706 490 M12968 GO_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 108/167 Gene Ontology BP GO:0090279 2.11983353257999e-07 5.09746016904119e-07 1210 1089.09090909091 934 1.9271215789444e-08 50 2.19513636855007 2.13694107387287 1 16.602709445989 1206 50 455 507 1862 409 1926 1917 2069 645 934 491 M13915 GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT.html Any apoptotic process that is involved in anatomical structure development. 27/38 Gene Ontology BP GO:1902742 4.85509391117539e-07 8.66209814750732e-07 800 1116 934 4.41372271147945e-08 414 2.69810789903356 2.97727163998144 1 19.6790904263881 800 2056 1174 1019 2561 572 934 414 525 1555 666 492 M13480 GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. 36/47 Gene Ontology BP GO:0000038 9.43658670530193e-08 4.02645553947883e-07 295 1136.54545454545 935 8.57871555460992e-09 273 1.7153575542003 -1.28989910656535 -1 13.1639421344483 292 640 2177 2415 935 273 307 1146 1443 2134 740 493 M15905 GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. 44/77 Gene Ontology BP GO:1902930 1.10011134179827e-07 4.02645553947883e-07 590 1138.27272727273 935 1.00010126982673e-08 164 2.37017734914334 -2.05175633709017 -1 18.2284423448353 587 546 935 2404 1146 689 164 1511 2326 1433 780 494 M12233 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 39/43 Gene Ontology BP GO:0010656 6.92994740182965e-08 4.02645553947883e-07 2640 1535 936 6.29995238192851e-09 549 2.46121535671793 2.62808559588679 1 18.9325475231995 2640 549 762 635 559 1888 2624 3535 936 823 1934 495 M15566 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 53/65 Gene Ontology BP GO:0010596 1.09751244436249e-07 4.02645553947883e-07 400 1027.72727272727 937 9.97738635558198e-09 237 2.12058396101354 2.11461421783414 1 16.298039848673 396 1900 1400 769 1142 237 937 507 1346 2100 571 496 M10535 GO_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COCAINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. 45/70 Gene Ontology BP GO:0042220 1.51886071000327e-07 4.38336566905022e-07 970 983.363636363636 939 1.38078255896736e-08 21 2.63633247142398 2.81207794773417 1 20.1693339280711 967 504 631 904 2222 939 2311 21 1154 1127 37 497 M14286 GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE.html Any process in by an organism or tissue maintains a population of neuronal stem cells. 30/36 Gene Ontology BP GO:0097150 3.97202415214685e-08 4.02645553947883e-07 3580 1699.63636363636 939 3.61093111260033e-09 138 2.6115118535451 -2.22727304546689 -1 20.0949690713566 3577 691 788 721 138 4105 3217 1558 208 939 2754 498 M15337 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. 30/42 Gene Ontology BP GO:0032743 4.41726103618764e-08 4.02645553947883e-07 3375 1891.54545454545 940 4.01569193170859e-09 172 1.85721938063113 -1.93235057181654 -1 14.2611283456063 3371 705 2058 790 172 4273 3927 763 641 940 3167 499 M12312 GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of adenylate cyclase activity. 44/86 Gene Ontology BP GO:0045761 4.69046677040456e-08 4.02645553947883e-07 945 1209.72727272727 941 4.26406079127886e-09 204 2.53105627967604 2.70300491392792 1 19.4727104378617 941 518 917 1740 204 367 1387 3346 2192 1034 661 500 M15611 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 40/48 Gene Ontology BP GO:0050654 4.36016605738016e-07 8.0860313531247e-07 70 1282 941 3.96378811047177e-08 67 2.34585243788208 2.68631932586982 1 17.1812092771518 67 584 961 3650 2462 198 243 409 2828 1759 941 501 M15651 GO_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a T cell. 30/50 Gene Ontology BP GO:0002456 1.02365607297255e-07 4.02645553947883e-07 3430 1336.90909090909 941 9.30596473275536e-09 83 2.66387622788183 -2.41407357352668 -1 20.4999650517671 3427 679 920 690 1041 2917 1523 1575 83 941 910 502 M12413 GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 69/99 Gene Ontology BP GO:0070167 1.02785397368461e-07 4.02645553947883e-07 3060 1736 942 9.34412747006007e-09 261 2.84284856911941 2.54423393701728 1 21.8841710071323 3059 261 319 410 1044 3507 4415 942 575 701 3863 503 M13009 GO_TERPENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERPENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. 87/174 Gene Ontology BP GO:0006721 1.86636479505095e-07 4.81781975852907e-07 430 1212.27272727273 943 1.6966954121669e-08 296 2.45852532036232 2.35980749915001 1 18.6800373709993 427 1849 724 2372 1719 296 552 1046 2689 718 943 504 M12587 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization. 34/39 Gene Ontology BP GO:0031113 9.50873716760409e-08 4.02645553947883e-07 1075 1405.81818181818 945 8.64430688962393e-09 290 1.62140787152413 1.69184102539928 1 12.4373175098513 1071 2010 3118 2302 945 427 773 671 547 3310 290 505 M16319 GO_KINETOCHORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 12/12 Gene Ontology BP GO:0051383 9.76762205450048e-07 1.46516095500451e-06 260 1297.63636363636 945 8.8796603555996e-08 72 1.86479314455612 2.15597143967517 1 13.0545802381768 258 1175 2213 2395 3064 587 72 685 945 2090 790 506 M14465 GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. 7/18 Gene Ontology BP GO:0033604 1.84765795560962e-05 2.10096590113674e-05 950 1728.45454545455 946 1.84767331806903e-06 21 3.65896789767139 3.65896789767139 1 20.5960212696449 946 3100 4496 1339 4087 855 347 569 21 2529 724 507 M10269 GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 18/26 Gene Ontology BP GO:0051284 4.24879494561445e-07 7.94453219248685e-07 150 1158.45454545455 949 3.86254160561079e-08 148 1.71805440452265 1.81961426789166 1 12.5715438504034 148 949 2266 2261 2440 183 218 827 1049 1951 451 508 M11508 GO_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_CYCLE.html Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 22/27 Gene Ontology BP GO:0042634 7.59771854182817e-08 4.02645553947883e-07 3940 1946.90909090909 949 6.90701709474187e-09 128 3.0781948501463 -2.22110686880661 -1 23.7043836808774 3936 865 607 422 658 4227 3624 1915 128 949 4085 509 M16921 GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 410/508 Gene Ontology BP GO:0031346 7.64096904165609e-08 4.02645553947883e-07 1505 1120.54545454545 949 6.94633573367252e-09 308 2.13399361609566 2.44146952662057 1 16.4017526586844 1504 1495 308 484 669 949 2997 796 1309 575 1240 510 M14565 GO_HAIR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hair cell. 41/64 Gene Ontology BP GO:0035315 4.98007701198349e-08 4.02645553947883e-07 1995 1098.90909090909 950 4.52734284065099e-09 247 2.16798702811884 -2.05184690179034 -1 16.6646641400914 1991 519 1272 950 247 1678 762 908 359 2406 996 511 M16163 GO_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 407/596 Gene Ontology BP GO:0048568 8.65168614653705e-10 1.80521505111376e-08 2095 1367.72727272727 952 7.86516922721763e-11 58 2.21167617077241 2.24451075003118 1 20.6092420456099 2093 1497 154 58 805 791 3918 3330 1231 216 952 512 M13063 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. 12/30 Gene Ontology BP GO:0002532 1.0144847420523e-06 1.50576322679643e-06 665 1386.09090909091 954 9.22259281692155e-08 243 2.39529099275658 -2.67259741609094 -1 16.7632575813245 664 2254 1820 1618 3090 954 606 243 566 2569 863 513 M14930 GO_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_SYSTEM_PROCESS.html A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. 272/419 Gene Ontology BP GO:0003012 1.99990962881593e-15 1.03395327809784e-13 1145 1009.90909090909 955 1.81809966255993e-16 52 2.4885765292446 2.78856150198689 1 38.9792110387251 1145 1564 52 327 234 955 3407 1252 1131 159 883 514 M13655 GO_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_SALVAGE.html Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. 13/17 Gene Ontology BP GO:0043174 2.68475263045291e-06 3.50411051598804e-06 960 1525.81818181818 956 2.44068718797744e-07 170 1.39483277567494 1.46970658750874 1 9.09983238730734 956 1145 2820 3674 3535 397 170 207 703 2786 391 515 M14890 GO_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTHENED_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. 67/88 Gene Ontology BP GO:0007224 9.62250458491453e-08 4.02645553947883e-07 125 1601.27272727273 956 8.74773182344548e-09 20 1.51429192299891 1.52283390856367 1 11.6088624936296 124 3195 3247 3211 956 20 98 512 3180 2627 444 516 M10207 GO_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION.html The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. 47/80 Gene Ontology BP GO:0051899 1.25248003153802e-07 4.14772809944564e-07 960 1048.36363636364 957 1.13861827531169e-08 115 2.96882762019777 3.50184046384893 1 22.8122448228508 957 1906 339 1773 1295 759 1120 115 2097 666 505 517 M12429 GO_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 102/151 Gene Ontology BP GO:0009308 1.85167143240237e-07 4.78657065276013e-07 795 1084.81818181818 957 1.68333780750164e-08 105 2.19484969661298 -2.23842552131123 -1 16.6730720965238 793 105 1182 1891 1717 332 848 957 2093 863 1152 518 M12069 GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 121/221 Gene Ontology BP GO:0002263 1.56418824614086e-07 4.41807401483567e-07 395 961.818181818182 958 1.4219894157762e-08 17 1.85029321740375 -1.93534757674044 -1 14.1173566238256 394 17 1362 1522 1558 765 615 779 1459 958 1151 519 M12028 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. 65/82 Gene Ontology BP GO:1904377 3.06082271358563e-08 3.81823273091526e-07 4650 2016.27272727273 960 2.78256614197303e-09 67 2.24479242544017 -2.00579047226365 -1 17.3212973552607 4647 273 872 499 67 4580 3349 2719 186 960 4027 520 M15390 GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 12/22 Gene Ontology BP GO:0046135 3.84164644902026e-08 4.02645553947883e-07 530 1320.54545454545 960 3.49240592373019e-09 10 3.4643766335536 3.8691980116459 1 26.6911866737283 527 3069 1554 2211 2647 960 680 10 166 2088 614 521 M12779 GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the cytosol. 53/99 Gene Ontology BP GO:0060401 5.83058873156636e-08 4.02645553947883e-07 1625 1256.09090909091 961 5.30053535099323e-09 345 2.5730524660312 3.17017052275747 1 19.7975168903754 1623 345 352 425 382 2234 4271 1081 1669 474 961 522 M13092 GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION.html Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. 37/62 Gene Ontology BP GO:0002026 2.2787668077817e-07 5.28061287442561e-07 1085 1213.90909090909 961 2.0716064034701e-08 434 2.38106042898691 2.48449821679159 1 17.9735026815479 1085 624 1052 2004 1942 718 961 434 3389 692 452 523 M14254 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. 65/82 Gene Ontology BP GO:1903078 3.06082271358563e-08 3.81823273091526e-07 4650 2042.27272727273 961 2.78256614197303e-09 68 2.24479242544017 -2.00579047226365 -1 17.3212973552607 4648 274 873 500 68 4581 3350 2995 187 961 4028 524 M15720 GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 11/17 Gene Ontology BP GO:0002283 8.96443605937352e-08 4.02645553947883e-07 555 1585.54545454545 961 8.14948765877391e-09 42 1.41250277315758 -1.40528268846931 -1 10.8216059464579 551 1212 2850 3739 873 433 42 961 2634 3347 799 525 M12702 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 19/37 Gene Ontology BP GO:0090281 2.93949094288959e-06 3.80669394858483e-06 235 1553.45454545455 962 2.67226806404144e-07 235 1.41950726150267 1.4751367951763 1 9.20087732347142 235 962 2841 2758 3568 252 314 582 1927 2920 729 526 M12076 GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 23/34 Gene Ontology BP GO:0072529 2.7315353566826e-07 5.85706636619546e-07 965 1548.36363636364 963 2.48321426893818e-08 81 2.80871780876557 3.15957318316642 1 21.0673343743808 963 3534 1959 3670 2111 675 479 81 554 2358 648 527 M10333 GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. 41/51 Gene Ontology BP GO:0031109 6.11019321025347e-07 1.02786438927366e-06 965 1404.45454545455 965 5.55472264297736e-08 238 1.63231828929611 2.11848573972449 1 11.7182078455269 965 579 2907 2885 2724 396 238 304 1159 2975 317 528 M10686 GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE.html Any process in which a protein is transported to, or maintained at, the kinetochore. 12/13 Gene Ontology BP GO:0034501 1.97768079414878e-06 2.67271238314676e-06 90 1293.90909090909 965 1.79789324725354e-07 8 1.8371468712312 1.8371468712312 1 12.2794656934232 90 1170 2272 2881 3411 105 8 437 965 2079 815 529 M15227 GO_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MORPHOGENESIS.html The process in which bones are generated and organized. 97/125 Gene Ontology BP GO:0060349 4.83218712274636e-07 8.63778973574292e-07 180 1111.36363636364 965 4.39289834919254e-08 107 2.42571839761362 2.42546088803269 1 17.6855593959351 180 107 377 965 2554 492 1138 2051 2592 744 1025 530 M16808 GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase A. 13/16 Gene Ontology BP GO:0034199 3.15130359268748e-07 6.45393277958822e-07 710 1216.27272727273 967 2.86482185825789e-08 85 2.26073477606875 2.19831488301008 1 16.8217660450693 708 2231 1620 1736 2211 725 413 967 380 2303 85 531 M11111 GO_LYMPH_NODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_NODE_DEVELOPMENT.html The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. 11/17 Gene Ontology BP GO:0048535 3.01177812362569e-07 6.26175317659978e-07 970 1259.54545454545 970 2.73798048721381e-08 82 2.1561710839626 -2.36034910588167 -1 16.0731970615059 970 1233 2365 2220 2180 704 82 493 455 2898 255 532 M10087 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 108/165 Gene Ontology BP GO:0051928 1.00393363550497e-07 4.02645553947883e-07 1985 1142.09090909091 971 9.12666983016208e-09 58 2.48231860325574 2.61821756371565 1 19.0957640254432 1985 58 290 513 1006 971 2730 1873 1956 349 832 533 M12519 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. 24/27 Gene Ontology BP GO:0031112 5.71781502736146e-07 9.80722115300793e-07 975 1646.81818181818 974 5.19801501220548e-08 302 1.45433587400069 1.57447243632743 1 10.4651313847905 974 2093 3198 2545 2669 826 572 761 433 3742 302 534 M13430 GO_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_MIGRATION.html Any process that modulates the frequency, rate or extent of neuron migration. 68/79 Gene Ontology BP GO:2001222 4.0321412450785e-07 7.62756281788806e-07 440 1150.36363636364 974 3.66558362189645e-08 264 2.46517804336522 2.72075142632174 1 18.1359734581679 437 264 282 572 2491 1158 2607 1379 2134 356 974 535 M15663 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. 54/90 Gene Ontology BP GO:1901379 6.42846411772706e-08 4.02645553947883e-07 3150 1712.63636363636 974 5.84405845960789e-09 363 2.6505217376225 -2.08063276754521 -1 20.3966788969344 3150 363 569 481 470 3788 4162 3280 519 974 1083 536 M10442 GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS.html The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 32/50 Gene Ontology BP GO:0050951 7.49827642304694e-08 4.02645553947883e-07 2070 1385.09090909091 975 6.81661516237388e-09 191 2.69110038651463 2.87592603124092 1 20.7105218464581 2066 695 822 191 647 2176 3467 1668 975 933 1596 537 M14056 GO_BLASTODERM_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTODERM_SEGMENTATION.html The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. 20/27 Gene Ontology BP GO:0007350 2.95211390902939e-06 3.81985150687257e-06 470 1146 975 2.68374351853619e-07 388 3.25124611005669 3.3067265625157 1 21.200697689129 466 975 773 892 3571 478 388 998 1600 1217 1248 538 M15098 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. 15/16 Gene Ontology BP GO:0003198 9.5045786106542e-07 1.43534740556727e-06 955 1199 975 8.64052974262239e-08 365 2.62732070298025 -2.60728296196395 -1 18.4631632663111 952 1068 975 1578 3045 808 365 822 1637 1370 569 539 M10491 GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. 297/367 Gene Ontology BP GO:0032886 9.73796600613253e-08 4.02645553947883e-07 760 1202.09090909091 976 8.85269676106259e-09 384 1.67902784949671 1.93005045044261 1 12.8829613233374 759 1553 2499 1937 976 384 862 717 1280 1483 773 540 M12018 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. 402/532 Gene Ontology BP GO:0000226 1.10248577626794e-07 4.02645553947883e-07 755 1109.18181818182 976 1.00225984683346e-08 649 1.83442813236283 2.07082227862113 1 14.0848565185462 753 1507 1845 1897 1152 649 891 653 1140 976 738 541 M12569 GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. 46/63 Gene Ontology BP GO:0061005 1.24615155835139e-07 4.14338946095474e-07 2125 1074.45454545455 976 1.13286511721588e-08 325 2.70344817634029 3.28188205034257 1 20.7653722543534 2125 435 325 417 1288 976 1962 1893 524 346 1528 542 M16320 GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 21/23 Gene Ontology BP GO:0046325 7.98015197569193e-08 4.02645553947883e-07 1995 1208.72727272727 976 7.25468387741756e-09 302 2.32101767111431 -2.54126339330014 -1 17.8482320921165 1992 906 1497 976 732 2167 867 302 1480 1695 682 543 M10588 GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. 46/54 Gene Ontology BP GO:0030517 2.11745240463485e-07 5.09436713483245e-07 700 1181.63636363636 978 1.92495691675917e-08 252 2.58030888060908 2.89517609391011 1 19.5348140868086 696 1909 615 1709 1861 978 1382 252 2234 517 845 544 M14412 GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). 80/201 Gene Ontology BP GO:0007188 7.58095627700475e-08 4.02645553947883e-07 1290 1332.63636363636 978 6.89177867112375e-09 226 2.26015580168361 2.45309613199226 1 17.3775148766066 1290 226 892 2646 657 1094 3309 978 2486 700 381 545 M15257 GO_REGULATION_OF_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ASSEMBLY.html Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 20/28 Gene Ontology BP GO:0090169 9.76466286490713e-08 4.02645553947883e-07 105 1760.36363636364 979 8.87696663482731e-09 15 1.10829998448224 -0.940304356117476 -1 8.46884401234352 101 2158 3532 4185 979 116 15 283 3882 4083 30 546 M15541 GO_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_STORAGE.html The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 29/37 Gene Ontology BP GO:0019915 1.35439138821799e-07 4.23886744058351e-07 420 841.454545454545 979 1.23126497418066e-08 239 2.25344117792873 -2.35003277780616 -1 17.2647350016496 419 688 1090 1054 1384 483 573 1306 979 1041 239 547 M11083 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. 15/46 Gene Ontology BP GO:0002719 5.88107705016697e-07 1.00017001149221e-06 980 1076.90909090909 980 5.34643511118817e-08 298 2.53101316790538 -3.23263108292136 -1 18.2628197982945 980 1067 1212 509 2694 1666 1383 298 707 783 547 548 M13865 GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. 15/15 Gene Ontology BP GO:0051988 2.07396198271383e-06 2.78825342547456e-06 495 1198.54545454545 980 1.88542176169191e-07 215 2.16748124928475 2.6533162779426 1 14.4577486463794 495 1026 1805 1141 3432 817 825 665 215 1783 980 549 M15892 GO_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. 121/178 Gene Ontology BP GO:0007498 6.34544311571869e-08 4.02645553947883e-07 945 1083.27272727273 980 5.76858481703619e-09 33 2.04607523541134 2.30842955224059 1 15.7217752650392 942 33 980 2229 452 516 1385 1584 2102 1284 409 550 M15907 GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. 61/93 Gene Ontology BP GO:0045071 6.54858140425123e-06 7.93917385981787e-06 45 1405.90909090909 982 5.95327354274786e-07 45 2.35731499899985 -2.56999984339671 -1 14.4374282887706 45 2465 886 1902 3813 947 567 481 2061 982 1316 551 M11493 GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 113/180 Gene Ontology BP GO:0051282 1.05681572886959e-07 4.02645553947883e-07 1990 1345.27272727273 983 9.6074161785085e-09 10 2.16524778559409 2.35175499559675 1 16.6434783200383 1990 10 424 432 1086 983 3159 3127 2170 588 829 552 M16151 GO_AORTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_MORPHOGENESIS.html The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. 44/54 Gene Ontology BP GO:0035909 1.03835177558348e-07 4.02645553947883e-07 75 1359.54545454545 983 9.43956204174015e-09 73 3.45216924455307 3.63156098833658 1 26.5967724171055 73 2499 252 983 4125 781 1786 1841 1342 619 654 553 M10630 GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. 20/23 Gene Ontology BP GO:0045618 1.56907166546803e-06 2.17677115665556e-06 470 1379.45454545455 984 1.42642980413968e-07 468 1.7643621237936 -1.70680377958116 -1 11.9791014596966 984 979 2523 1198 3322 832 470 468 1220 2275 903 554 M12165 GO_HYPOTHALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPOTHALAMUS_DEVELOPMENT.html The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. 18/35 Gene Ontology BP GO:0021854 1.35698468606254e-06 1.91858090071377e-06 875 1406.63636363636 984 1.23362320278786e-07 387 2.37392767928981 2.71402262176677 1 16.3107310622945 875 980 1544 984 3261 711 387 413 3329 1525 1464 555 M10878 GO_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. 7/16 Gene Ontology BP GO:0006182 4.43194444554067e-07 8.17030012087984e-07 150 1283.09090909091 985 4.43194532943683e-08 5 2.42652510438352 2.42652510438352 1 17.7623895039559 147 2299 4268 1507 2565 191 5 985 719 1285 143 556 M16767 GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM.html A circulatory process that occurs at the level of the vasculature. 146/233 Gene Ontology BP GO:0003018 7.93398163825142e-13 2.81807760021251e-11 905 1197.27272727273 987 7.21271058023116e-14 82 2.51238769138676 2.71322601368845 1 31.9530963763722 902 1755 82 683 1863 496 2047 2115 2096 144 987 557 M11897 GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of astrocyte differentiation. 34/50 Gene Ontology BP GO:0048710 1.84056708794777e-08 2.79874466020293e-07 3635 1865.54545454545 990 1.67324282122395e-09 11 2.74998129684155 3.20344473694974 1 21.691263257077 3631 672 737 990 11 3514 3114 3379 456 771 3246 558 M12832 GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. 37/61 Gene Ontology BP GO:0034123 2.29461138786523e-07 5.3118541232522e-07 1020 1001 992 2.08601057017675e-08 221 2.83694010052257 -2.94856326012461 -1 21.4256462505423 1020 617 992 748 1946 1471 1159 330 221 1685 822 559 M13357 GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS.html A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 18/28 Gene Ontology BP GO:0097067 1.38113019893772e-07 4.24835370983751e-07 540 1032.90909090909 992 1.25557298694837e-08 233 2.57344566726917 -2.91103522138958 -1 19.7280479366459 540 992 1465 737 1409 1261 570 393 233 2762 1000 560 M12496 GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. 46/74 Gene Ontology BP GO:1903307 9.94345054137357e-08 4.02645553947883e-07 980 1234.09090909091 993 9.03950090072065e-09 402 2.28403667663057 -1.98272777285067 -1 17.5622140825975 978 1925 1245 1302 993 546 402 790 2724 872 1798 561 M12926 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 50/63 Gene Ontology BP GO:2001240 9.46345387653736e-07 1.43198214268385e-06 215 1453.36363636364 993 8.60314358846427e-08 121 2.49257121131786 2.55485395784976 1 17.514020882575 211 2874 743 1448 3038 240 667 2452 3200 993 121 562 M13006 GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS.html The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 166/326 Gene Ontology BP GO:0050953 4.57844149716544e-09 8.13110239935526e-08 710 1332.63636363636 993 4.1622195515397e-10 186 2.47099821822022 2.63691641644243 1 21.0844840620703 706 1729 186 2166 1761 993 2614 964 2304 354 882 563 M12776 GO_EMBRYONIC_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_MORPHOGENESIS.html Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 283/440 Gene Ontology BP GO:0048562 4.10310913472987e-10 9.13481665258281e-09 1245 1068.09090909091 994 3.73009921408647e-11 63 2.2338389304219 2.43434522086202 1 21.6160064019351 1243 1559 142 428 994 566 3240 2056 1264 194 63 564 M10316 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 62/84 Gene Ontology BP GO:0010518 2.18647551662468e-07 5.15590364235942e-07 1195 1064.36363636364 995 1.98770521266193e-08 233 2.59418520561969 -2.88905740891212 -1 19.6240614990368 1191 338 460 233 1904 1440 1424 279 2954 490 995 565 M12833 GO_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TASTE.html The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. 28/88 Gene Ontology BP GO:0050909 4.04530693990539e-08 4.02645553947883e-07 550 1049.27272727273 995 3.6775518311723e-09 140 2.60644496865699 -2.62151795239908 -1 20.0557808247886 547 2567 1179 1490 140 239 166 995 2435 1408 376 566 M16493 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. 50/63 Gene Ontology BP GO:1901099 9.46345387653736e-07 1.43198214268385e-06 215 1451.81818181818 995 8.60314358846427e-08 122 2.49257121131786 2.55485395784976 1 17.514020882575 212 2875 744 1449 3039 241 668 2424 3201 995 122 567 M11402 GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. 10/17 Gene Ontology BP GO:0045835 1.59469806644096e-07 4.451187824325e-07 655 1308.45454545455 996 1.44972562003154e-08 50 1.795796358391 1.41725776656916 1 13.6914812706305 655 1224 2250 2676 1581 232 50 996 295 3630 804 568 M16315 GO_CENTROMERE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROMERE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. 37/52 Gene Ontology BP GO:0034508 8.21166142640074e-07 1.28346861326982e-06 10 1173.45454545455 997 7.46514953769565e-08 7 1.93778393649003 2.02142619508012 1 13.7043403148266 10 1962 1785 2832 2934 83 7 494 1096 997 708 569 M11632 GO_CARTILAGE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_MORPHOGENESIS.html The process in which the anatomical structures of cartilage are generated and organized. 13/20 Gene Ontology BP GO:0060536 2.93926469226613e-07 6.16053991581725e-07 985 1110.90909090909 999 2.67205916814601e-08 373 3.25553335047428 3.66262780697947 1 24.3487624650472 985 1148 937 999 2162 763 373 1853 1091 1374 535 570 M16063 GO_PEPTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 20/24 Gene Ontology BP GO:0043171 2.49171959967675e-08 3.44536160746657e-07 1370 1339.81818181818 999 2.26519966172541e-09 33 1.68300130236607 -1.83226240243258 -1 13.0514662854976 1366 974 2712 1979 33 1262 427 965 999 3390 631 571 M15023 GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of glia cell differentiation. 66/97 Gene Ontology BP GO:0045685 5.2989717234182e-08 4.02645553947883e-07 3665 1907 1000 4.81724713731863e-09 287 2.75342418057304 3.30877409764571 1 21.1925458636893 3664 303 515 614 287 2805 4335 3319 368 1000 3767 572 M12655 GO_BEHAVIORAL_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_PAIN.html Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 16/32 Gene Ontology BP GO:0048266 2.04631042539061e-07 5.00119458251237e-07 660 1489.27272727273 1002 1.86028237793307e-08 35 3.36405527310767 4.30262648191443 1 25.5322315077111 658 2666 1002 933 2999 1818 3261 35 718 1993 299 573 M10055 GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION.html The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. 19/24 Gene Ontology BP GO:0021801 2.80313674080747e-07 5.95298733682208e-07 440 1319 1004 2.54830645270005e-08 59 1.84107491845069 1.90280902250292 1 13.7581620168225 438 2171 2451 1004 2131 871 1132 59 593 3248 411 574 M16705 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. 41/61 Gene Ontology BP GO:0002763 8.00447941458727e-08 4.02645553947883e-07 930 1588.45454545455 1004 7.27679973256569e-09 495 2.35578091676242 -3.15136737889853 -1 18.1170976124601 930 2891 1411 2739 734 929 970 495 4021 1349 1004 575 M12797 GO_TELENCEPHALON_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_GLIAL_CELL_MIGRATION.html The orderly movement of glial cells through the telencephalon. 19/24 Gene Ontology BP GO:0022030 2.80313674080747e-07 5.95298733682208e-07 440 1323.54545454545 1005 2.54830645270005e-08 94 1.84107491845069 1.90280902250292 1 13.7581620168225 439 2172 2452 1005 2132 872 1133 94 594 3254 412 576 M13820 GO_RESPONSE_TO_CAFFEINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAFFEINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. 28/34 Gene Ontology BP GO:0031000 2.47953819008481e-08 3.44396752192973e-07 925 1335.18181818182 1005 2.25412565275524e-09 32 2.2743362548145 2.26524522554728 1 17.6738539061619 922 2052 2086 1653 32 879 932 615 2142 2369 1005 577 M14065 GO_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 266/418 Gene Ontology BP GO:0008544 5.42104772939165e-21 6.30603377121484e-19 1955 1073.18181818182 1007 4.92822520853784e-22 20 2.67006997539287 3.31085132451754 1 58.668823845276 1951 1568 20 336 231 1007 3503 1102 1472 78 537 578 M13605 GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 17/20 Gene Ontology BP GO:0036109 4.52888719935921e-07 8.28989462573501e-07 395 1447.54545454545 1009 4.1171710287904e-08 86 1.57337611183283 -1.39586163345485 -1 11.4690514746803 393 1009 2736 3178 2493 406 86 749 2375 2182 316 579 M10820 GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 424/544 Gene Ontology BP GO:0010769 3.42571087844858e-14 1.44907570158375e-12 1010 1037.45454545455 1010 3.11428261677148e-15 67 2.26327144293884 2.5401595086279 1 32.302438212463 1010 1473 67 386 917 752 2690 1381 1363 105 1268 580 M12513 GO_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 18/33 Gene Ontology BP GO:0042417 6.00322402898357e-07 1.01484919564643e-06 920 1478.45454545455 1010 5.45747787918807e-08 588 1.81107451305536 1.97219686169216 1 13.024873127513 917 996 1756 1965 2709 1010 588 2674 1751 929 968 581 M10725 GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. 29/44 Gene Ontology BP GO:0007202 4.15270151079942e-07 7.8070788403029e-07 1015 1223 1011 3.77518390423643e-08 296 2.9676181834067 -3.0218474414104 -1 21.8170811757706 1011 776 706 1161 2427 1170 1000 296 3230 1038 638 582 M12526 GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. 14/23 Gene Ontology BP GO:0021681 1.55809482175605e-07 4.41300019561337e-07 4640 1924.81818181818 1012 1.41644993827657e-08 63 2.98718814838865 -2.73522647252384 -1 22.8566953911138 4638 1012 483 63 1551 4426 3602 596 80 635 4087 583 M12831 GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL.html Any process that modulates the potential difference across a post-synaptic membrane. 35/76 Gene Ontology BP GO:0060078 1.75863094621554e-07 4.66677501662496e-07 515 1070.09090909091 1012 1.59875553345145e-08 241 2.94847786518632 3.36210658901616 1 22.4725765321599 511 637 575 1754 1673 926 1589 241 1618 1235 1012 584 M16341 GO_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 87/169 Gene Ontology BP GO:0030814 4.62549760986699e-08 4.02645553947883e-07 775 1404.27272727273 1012 4.20499791556184e-09 177 2.43348630271951 2.62772974837384 1 18.7180857722057 1408 177 726 1732 192 771 2543 4041 2074 1012 771 585 M11043 GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of glia cell differentiation. 33/45 Gene Ontology BP GO:0045687 1.73554396880876e-07 4.63043926999263e-07 2375 1399.36363636364 1014 1.57776736883909e-08 402 2.75426799977801 -2.32417867525817 -1 20.9968825367927 2371 668 749 963 1663 2606 1448 2651 402 1014 858 586 M15304 GO_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 204/277 Gene Ontology BP GO:0048863 2.14688311681239e-15 1.09774144423385e-13 835 1000.72727272727 1014 1.9517119243749e-16 53 2.57232805003074 2.74159362990404 1 40.2136150447229 832 1638 53 429 1014 670 1360 1894 1732 93 1293 587 M15529 GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 27/44 Gene Ontology BP GO:0002089 8.07180049550776e-08 4.02645553947883e-07 2545 1658.63636363636 1015 7.33800071969285e-09 17 1.87083222899649 2.44298246426475 1 14.3664126909221 2545 792 1884 656 743 3571 4112 1015 351 2559 17 588 M10383 GO_EPIDERMIS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_MORPHOGENESIS.html The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 39/52 Gene Ontology BP GO:0048730 1.26624301789086e-07 4.16747130248656e-07 530 1068.81818181818 1016 1.15113008251944e-08 399 3.15288422908566 4.25318928784545 1 24.2250408848187 1659 529 399 530 1305 1016 1703 1995 411 688 1522 589 M12643 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. 14/15 Gene Ontology BP GO:0071459 7.01566467438442e-07 1.13307489517219e-06 155 964.454545454545 1016 6.37787901057976e-08 32 2.10905589981259 1.95187538272054 1 15.0627650693658 155 1076 1689 1097 2837 165 32 692 283 1567 1016 590 M10808 GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. 120/184 Gene Ontology BP GO:0048706 7.02036629727043e-07 1.13321533546309e-06 530 1217 1018 6.38215321593035e-08 34 2.24470266011439 2.51343119247034 1 16.0380227633656 530 34 390 592 2838 1306 2447 1467 2238 527 1018 591 M14957 GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM.html The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. 43/51 Gene Ontology BP GO:0001738 1.16690521159464e-07 4.08548528935279e-07 1050 1049.81818181818 1018 1.06082297589876e-08 158 2.73791423682017 3.06205899856811 1 21.0516596133621 1048 520 1018 750 1214 906 1255 3093 158 1326 260 592 M11939 GO_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHESION.html The attachment of a cell to the underlying substrate via adhesion molecules. 210/262 Gene Ontology BP GO:0031589 9.90806988069325e-10 2.05813612298508e-08 455 1201.27272727273 1019 9.00733625923232e-11 156 2.37775810300465 2.47543216939795 1 22.0008336998834 454 1644 156 856 1424 820 3042 1342 2185 272 1019 593 M14633 GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 19/21 Gene Ontology BP GO:0010649 1.54333521237337e-07 4.40560659090385e-07 1105 1062.90909090909 1019 1.40303210967347e-08 472 2.34433523382842 2.60380247539271 1 17.9177656832922 1102 935 1607 1394 1536 1019 657 574 669 1727 472 594 M11622 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 78/85 Gene Ontology BP GO:0007173 8.98916564939885e-08 4.02645553947883e-07 285 1057.45454545455 1020 8.17196910608615e-09 221 2.0192914605949 -2.12815293390264 -1 15.514624482121 285 221 1745 783 879 1237 1298 693 1020 2271 1200 595 M11824 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of extracellular matrix assembly. 16/16 Gene Ontology BP GO:1901201 5.27233417563733e-08 4.02645553947883e-07 2530 1476.63636363636 1020 4.79303118362693e-09 283 1.57200343538488 -1.84187513081138 -1 12.0552142515906 2528 1013 2376 1020 283 2288 942 947 735 1538 2573 596 M14931 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. 46/60 Gene Ontology BP GO:0035088 6.51119947791809e-08 4.02645553947883e-07 1815 1329.54545454545 1021 5.91927242784174e-09 98 2.55368664793719 2.94475027476786 1 19.6477379885021 1811 450 738 98 484 2047 2233 4524 152 1021 1067 597 M10648 GO_EMBRYONIC_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. 32/46 Gene Ontology BP GO:0000578 1.0532514823258e-07 4.02645553947883e-07 1160 1056.63636363636 1022 9.57501393409348e-09 172 2.14207763306428 -1.80881450325115 -1 16.4642759757168 1157 714 1858 172 1080 571 407 1728 373 2541 1022 598 M13935 GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 71/88 Gene Ontology BP GO:0043535 1.01194312838948e-07 4.02645553947883e-07 905 1394 1022 9.19948340851139e-09 265 1.7973952666002 1.87332552155086 1 13.7984373267403 905 265 1996 799 1022 767 904 3363 1084 1945 2284 599 M15632 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. 46/60 Gene Ontology BP GO:0061245 6.51119947791809e-08 4.02645553947883e-07 1815 1331 1022 5.91927242784174e-09 99 2.55368664793719 2.94475027476786 1 19.6477379885021 1812 451 739 99 485 2048 2234 4530 153 1022 1068 600 M15042 GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of muscle tissue development. 64/88 Gene Ontology BP GO:1901863 6.62474953155397e-08 4.02645553947883e-07 2740 1404.90909090909 1023 6.02249975549249e-09 215 2.14207694044033 2.29176790326901 1 16.4642706188321 2740 252 874 215 502 1809 1992 2676 265 1023 3106 601 M13126 GO_NEURON_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. 11/44 Gene Ontology BP GO:0048665 2.0305666856078e-06 2.73386191786258e-06 1670 1141.36363636364 1026 1.8459714179932e-07 228 3.03219311612256 3.47060617221638 1 20.2980851069817 1667 1185 1026 228 3425 1216 1020 379 619 1356 434 602 M12487 GO_LIPOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOXYGENASE_PATHWAY.html The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. 10/15 Gene Ontology BP GO:0019372 1.1821557581148e-07 4.09573398548636e-07 1230 987.272727272727 1027 1.07468711057926e-08 177 2.72494685444778 -2.55288197922783 -1 20.9478807002351 975 1227 1495 177 1227 1027 540 1484 271 1614 823 603 M12357 GO_DETECTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS.html The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. 31/46 Gene Ontology BP GO:0016048 7.87620105569013e-08 4.02645553947883e-07 1390 1147.18181818182 1028 7.1601830342412e-09 197 2.70580418979259 2.80407635805193 1 20.8242438435172 1388 712 898 197 707 1640 2679 1981 230 1028 1159 604 M13134 GO_CELL_SEPARATION_AFTER_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SEPARATION_AFTER_CYTOKINESIS.html The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components. 17/17 Gene Ontology BP GO:0000920 5.35420736657431e-08 4.02645553947883e-07 780 1558.18181818182 1028 4.86746136080117e-09 192 1.13103988623532 -0.78831117744817 -1 8.64471871573831 780 1028 3357 3203 303 561 192 1821 1118 3921 856 605 M11775 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of hair follicle development. 14/18 Gene Ontology BP GO:0051797 1.12790544171038e-07 4.05064193023647e-07 3245 1484.63636363636 1030 1.02536863594211e-08 34 3.61144561575485 4.8153355379441 1 27.8172859318076 3244 1030 527 414 1178 3128 3427 793 34 884 1672 606 M14567 GO_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 102/134 Gene Ontology BP GO:0072091 9.03185039775647e-08 4.02645553947883e-07 810 1334.90909090909 1030 8.21077342595351e-09 313 2.09558610948241 2.41655890623444 1 16.1047017344065 809 2414 1606 1030 886 1000 2128 561 2753 1184 313 607 M15108 GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. 17/19 Gene Ontology BP GO:0002313 1.23361026449355e-07 4.14338946095474e-07 2715 1311.90909090909 1031 1.12146393969639e-08 184 2.60391229914886 -2.18638098829233 -1 19.9970395910578 2712 984 1028 184 1269 2354 828 2544 436 1061 1031 608 M15205 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. 31/41 Gene Ontology BP GO:0035850 1.01707776152416e-07 4.02645553947883e-07 3405 1638 1033 9.24616189585898e-09 321 2.75342799837703 3.48820141532932 1 21.1925753913078 3401 651 439 416 1033 2023 2803 2767 321 432 3732 609 M14155 GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. 83/102 Gene Ontology BP GO:0035305 1.04373153620011e-07 4.02645553947883e-07 1260 1247.72727272727 1034 9.48846896106532e-09 202 1.7596331515354 -1.59325465300072 -1 13.5063779828303 1256 202 2679 1952 1066 774 698 1034 841 2626 597 610 M11070 GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. 36/46 Gene Ontology BP GO:0045747 1.01888435609749e-07 4.02645553947883e-07 4605 2162 1035 9.26258548440919e-09 185 2.84129464498658 3.4243167231789 1 21.8721526638287 4604 600 641 185 1035 4245 4204 3795 327 761 3385 611 M13761 GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell. 36/55 Gene Ontology BP GO:0042491 1.0119773578776e-07 4.02645553947883e-07 2565 1253.18181818182 1035 9.19979458570475e-09 239 2.30936474326725 -2.17623102947785 -1 17.7581061429793 2562 572 1132 928 1023 2332 1187 1035 239 2135 640 612 M15089 GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. 137/213 Gene Ontology BP GO:0045834 1.00420447420129e-07 4.02645553947883e-07 1785 1217.27272727273 1035 9.12913200035332e-09 238 2.07603714516588 -2.04979031588924 -1 15.9535063449902 1783 1785 998 238 1007 938 1631 1684 1792 499 1035 613 M13840 GO_REGULATION_OF_EXOSOMAL_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOSOMAL_SECRETION.html Any process that modulates the frequency, rate or extent of exosomal secretion. 18/20 Gene Ontology BP GO:1903541 1.89437413347171e-07 4.85648641490021e-07 275 1476.18181818182 1036 1.72215845144758e-08 19 1.16669995119072 -1.13136532862532 -1 8.80566572500532 271 1036 3255 2963 1733 71 19 2068 465 4154 203 614 M15384 GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. 26/37 Gene Ontology BP GO:0099601 1.00896877250825e-06 1.50039363965513e-06 780 1346.36363636364 1036 9.17244759312724e-08 422 3.16894193244325 3.51804441753254 1 22.2167936639841 1165 780 422 2200 3088 779 1036 2580 1729 471 560 615 M11677 GO_REFLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REFLEX.html An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. 24/41 Gene Ontology BP GO:0060004 8.93154533303297e-07 1.36840567779396e-06 750 1239.18181818182 1039 8.11958996277987e-08 129 2.53516025958987 2.65951164691741 1 17.8755017041768 746 809 853 129 2997 1039 254 2135 2384 1186 1099 616 M16862 GO_ACUTE_PHASE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_PHASE_RESPONSE.html An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. 42/111 Gene Ontology BP GO:0006953 4.34185071059209e-07 8.05527566044059e-07 1040 1481.90909090909 1039 3.94713778862392e-08 286 3.34098235644174 -3.01316038892074 -1 24.5199824670565 1039 522 286 672 3231 2284 1428 3460 657 624 2098 617 M11909 GO_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSPORT.html The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 215/370 Gene Ontology BP GO:0015849 4.16050259073531e-11 1.13875403262891e-09 1970 1188.63636363636 1040 3.78227508255817e-12 117 2.32371716052206 -2.16577429398388 -1 25.0311335415227 1966 1622 117 1040 712 925 1001 2046 1244 195 2207 618 M14392 GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoblast differentiation. 136/162 Gene Ontology BP GO:0045667 1.0220972627481e-07 4.02645553947883e-07 1305 1028.45454545455 1040 9.29179372939716e-09 219 2.33433756390402 2.55036337809965 1 17.951250663572 1304 1789 372 939 1040 219 1995 1165 1263 978 249 619 M10425 GO_B_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 24/28 Gene Ontology BP GO:0001782 2.649558440095e-08 3.57344794833682e-07 1815 1424 1043 2.40868952000437e-09 42 2.07669363107685 -2.34566966305166 -1 16.0887709331473 1813 2969 2639 1025 42 1755 531 365 603 2879 1043 620 M11423 GO_REGULATION_OF_DOPAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of dopamine. 15/27 Gene Ontology BP GO:0014059 1.00455434581315e-07 4.02645553947883e-07 1370 914.454545454545 1043 9.13231265166065e-09 39 2.68876909865519 2.86780836431858 1 20.6924912249867 1368 1064 1127 712 1009 1254 1429 39 178 1043 836 621 M12576 GO_MACROMOLECULAR_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_REMODELING.html The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. 14/28 Gene Ontology BP GO:0034367 7.72619926164354e-08 4.02645553947883e-07 2685 1518.45454545455 1043 7.0238177572551e-09 391 3.30620356317799 3.72713622984279 1 25.4678462152064 2681 1043 391 691 688 3364 4566 1123 529 434 1193 622 M14048 GO_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. 546/697 Gene Ontology BP GO:0001944 8.85951658945409e-14 3.52336159749828e-12 620 1368.54545454545 1044 8.85951658945441e-15 74 2.40353141553038 2.61854510524608 1 33.1890276256762 617 1428 4470 1044 1619 391 1937 618 2186 74 670 623 M14867 GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). 14/28 Gene Ontology BP GO:0034369 7.72619926164354e-08 4.02645553947883e-07 2685 1517.72727272727 1044 7.0238177572551e-09 392 3.30620356317799 3.72713622984279 1 25.4678462152064 2682 1044 392 692 689 3365 4567 1105 530 435 1194 624 M11108 GO_NEGATIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LOCOMOTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. 318/444 Gene Ontology BP GO:0040013 6.68370934891423e-12 2.08274880471856e-10 595 988.818181818182 1045 6.07609940812231e-13 98 2.32848575200438 2.48190171589531 1 27.1603849563453 593 1541 98 376 448 1045 2271 1058 1329 203 1915 625 M13647 GO_BILE_ACID_AND_BILE_SALT_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_AND_BILE_SALT_TRANSPORT.html The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/63 Gene Ontology BP GO:0015721 2.50913818073223e-07 5.61029310665405e-07 1280 1242.81818181818 1045 2.28103496991259e-08 507 3.3198369730933 -3.65077633574562 -1 24.9948777844794 1031 716 514 1045 2020 2225 2134 925 507 1277 1277 626 M16168 GO_PROTEIN_LIPID_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_REMODELING.html The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. 14/28 Gene Ontology BP GO:0034368 7.72619926164354e-08 4.02645553947883e-07 2685 1517.72727272727 1045 7.0238177572551e-09 393 3.30620356317799 3.72713622984279 1 25.4678462152064 2683 1045 393 693 690 3366 4568 1095 531 436 1195 627 M10455 GO_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. 278/408 Gene Ontology BP GO:0007517 3.30154861946206e-12 1.07427312771727e-10 1245 1218.54545454545 1046 3.0014078358791e-13 93 2.43226069290303 2.68345902404248 1 29.2212122798046 1244 1574 93 1248 1046 937 3534 1006 1696 113 913 628 M15568 GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 92/182 Gene Ontology BP GO:0033559 5.26430348592848e-08 4.02645553947883e-07 1285 1150.18181818182 1046 4.78573055626925e-09 118 2.24270506019693 -2.20702192705941 -1 17.2425475396184 1285 118 770 1477 281 1046 855 1959 2600 644 1617 629 M16627 GO_NEPHRIC_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_MORPHOGENESIS.html The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. 17/25 Gene Ontology BP GO:0072178 3.69019084038234e-07 7.16010716095128e-07 595 1182.09090909091 1046 3.35471950850923e-08 594 2.42626484344616 2.88706384423267 1 17.9286640113168 594 1046 1637 1032 2342 1087 945 594 1353 1755 618 630 M12296 GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. 14/21 Gene Ontology BP GO:0048714 9.70353078229838e-08 4.02645553947883e-07 610 1021.54545454545 1047 8.82139200935602e-09 155 3.69787956674036 4.0891860586934 1 28.4971425464477 1386 1112 1047 610 969 1098 944 609 155 2037 1270 631 M11799 GO_LIPID_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. 17/42 Gene Ontology BP GO:0044241 8.5682040568842e-08 4.02645553947883e-07 1115 1209.63636363636 1048 7.7892767187134e-09 230 3.82564926936557 -3.85297715948113 -1 29.4853376053383 1111 2169 538 1048 828 1040 230 2769 742 1746 1085 632 M14450 GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. 13/23 Gene Ontology BP GO:0042402 1.03221140242207e-07 4.02645553947883e-07 870 1403.36363636364 1050 9.38374046229173e-09 391 1.87376196800408 -2.25726623486261 -1 14.3890718468225 867 1133 2131 3375 1050 863 391 580 3210 1383 454 633 M15199 GO_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 13/23 Gene Ontology BP GO:0009310 1.03221140242207e-07 4.02645553947883e-07 870 1401 1051 9.38374046229173e-09 392 1.87376196800408 -2.25726623486261 -1 14.3890718468225 868 1134 2132 3376 1051 864 392 544 3211 1384 455 634 M16730 GO_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. 376/476 Gene Ontology BP GO:0048589 4.96477816295024e-08 4.02645553947883e-07 1655 1170.27272727273 1052 4.51343479544659e-09 244 2.16716882501873 2.44625162403859 1 16.6583360024807 1655 1517 283 497 244 1052 3024 1948 1606 294 753 635 M11762 GO_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_PROCESS.html Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. 549/703 Gene Ontology BP GO:0007017 8.57969507068541e-08 4.02645553947883e-07 640 1487.27272727273 1053 8.57969540193566e-09 236 1.73237492401569 1.97552601369316 1 13.2955576929209 639 1432 4323 2831 937 236 765 1053 1440 2076 628 636 M14261 GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 24/37 Gene Ontology BP GO:0009190 1.28988207431536e-07 4.18245386187413e-07 160 1234.81818181818 1053 1.17262013631131e-08 157 2.38360853469407 2.37733629340623 1 18.284732848394 157 2586 1053 2653 1329 161 222 1550 2840 750 282 637 M16736 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS.html Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. 51/76 Gene Ontology BP GO:0021955 3.57547880973493e-07 7.01420683166559e-07 1085 1142.45454545455 1054 3.25043580984381e-08 422 2.53955000780872 2.75718584240219 1 18.7980422562993 1084 422 862 613 2315 1054 3002 431 1057 1253 474 638 M11375 GO_CARDIAC_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MYOFIBRIL_ASSEMBLY.html The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. 22/41 Gene Ontology BP GO:0055003 3.42036049493299e-07 6.84715782949634e-07 1100 1031 1055 3.10941911518158e-08 58 3.51462088503717 4.11856686190808 1 26.0996564796095 1100 874 499 1055 2268 1449 2341 58 370 1196 131 639 M13101 GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 15/19 Gene Ontology BP GO:0060192 8.24998405174305e-08 4.02645553947883e-07 2500 1305 1055 7.4999857828335e-09 128 2.54622000697334 2.03213727404357 1 19.5899895743211 2496 1055 1239 128 774 1534 912 1335 240 1044 3598 640 M11163 GO_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of muscle contraction. 147/232 Gene Ontology BP GO:0006937 4.2782559841937e-10 9.43446686940914e-09 1060 1127 1058 3.88932362275062e-11 144 2.68450795841887 2.72569661146689 1 25.9522200544332 1058 1752 144 418 400 1100 3769 721 1282 196 1557 641 M12265 GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. 40/72 Gene Ontology BP GO:1903792 6.72410071247964e-07 1.09702807206058e-06 720 1326.81818181818 1058 6.11282069785546e-08 318 2.5385039699777 2.57725905278291 1 18.1939310489547 720 605 1058 1927 2806 692 1076 318 3094 1272 1027 642 M16278 GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 15/19 Gene Ontology BP GO:0060315 5.72035207592167e-07 9.80722115300793e-07 350 1361 1059 5.20032142118663e-08 331 1.61516066871787 1.72660974393664 1 11.633782178576 347 1059 2558 2733 2671 331 467 519 1585 2238 463 643 M13784 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell migration. 83/93 Gene Ontology BP GO:0014910 1.17860203553313e-07 4.08807542125352e-07 640 1261.09090909091 1060 1.07145645334016e-08 199 2.42064352003452 2.83988052517708 1 18.5994473643063 637 215 728 1367 1221 1762 2657 199 2978 1060 1048 644 M16281 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. 81/94 Gene Ontology BP GO:1901989 2.4939601748772e-07 5.59787587732929e-07 2895 1372 1062 2.26723677963375e-08 237 1.8230732504263 2.029214233069 1 13.6815251927035 414 237 2892 2504 2011 657 489 1176 755 2895 1062 645 M13913 GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/47 Gene Ontology BP GO:0051954 1.00881756880434e-07 4.02645553947883e-07 1945 1467 1063 9.17106922785468e-09 83 2.76991398181525 2.82759425087612 1 21.3200811069812 1944 767 805 2184 1020 2846 3695 83 561 1169 1063 646 M12319 GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neutrophil migration. 23/50 Gene Ontology BP GO:1902624 2.69361927400884e-06 3.51272715301657e-06 1065 1561.54545454545 1064 2.44874779273416e-07 639 2.49130361419646 -3.00064721673283 -1 16.3308844974532 1064 898 1228 1804 3538 878 639 974 3757 1656 741 647 M14216 GO_DETECTION_OF_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_VISIBLE_LIGHT.html The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 39/83 Gene Ontology BP GO:0009584 9.04688156169603e-08 4.02645553947883e-07 2110 1520.45454545455 1064 8.22443812156693e-09 425 2.66853131766824 2.97474611203558 1 20.5359683970916 2107 566 1007 1064 888 2492 4645 733 425 1653 1145 648 M11339 GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/33 Gene Ontology BP GO:0032373 3.34329796009145e-06 4.29022763604676e-06 1330 1233.45454545455 1069 3.03936640077117e-07 114 3.35026537832114 4.05341409976206 1 21.6451693441852 1327 783 1069 186 3601 1651 1923 820 114 1406 688 649 M15839 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/33 Gene Ontology BP GO:0032376 3.34329796009145e-06 4.29022763604676e-06 1330 1230.72727272727 1070 3.03936640077117e-07 115 3.35026537832114 4.05341409976206 1 21.6451693441852 1328 784 1070 187 3602 1652 1924 774 115 1413 689 650 M15282 GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle development. 119/167 Gene Ontology BP GO:0048634 1.15965489751972e-07 4.08548528935279e-07 735 1088.18181818182 1071 1.05423178058816e-08 13 2.13613758519996 2.42237392592183 1 16.4020052663823 2069 13 733 230 1205 1071 2140 1738 732 873 1166 651 M13847 GO_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). 193/553 Gene Ontology BP GO:0002250 1.8078519779157e-07 4.72315286537998e-07 225 1048.72727272727 1072 1.64350193316011e-08 222 2.14164914426604 -2.20861355529626 -1 16.2814441467716 222 1666 484 704 1699 891 1072 1090 1950 655 1103 652 M11912 GO_FOREBRAIN_GENERATION_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_GENERATION_OF_NEURONS.html The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. 70/114 Gene Ontology BP GO:0021872 2.13904301189202e-07 5.12011405619142e-07 1050 1130.36363636364 1073 1.94458474533595e-08 241 2.59131689206881 2.87943181190167 1 19.6117305546811 1047 241 268 1344 2460 1073 1738 484 1649 301 1829 653 M12767 GO_POSITIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIVISION.html Any process that activates or increases the frequency, rate or extent of cell division. 126/192 Gene Ontology BP GO:0051781 9.14975075444668e-08 4.02645553947883e-07 1075 1328.81818181818 1075 8.31795557725708e-09 27 2.06920131533411 2.17723124456297 1 15.9006367434776 1075 27 1083 2024 901 672 665 2618 3197 967 1388 654 M12981 GO_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. 190/204 Gene Ontology BP GO:0000819 2.10435834725438e-07 5.07398994174999e-07 725 1177.27272727273 1075 1.91305322594715e-08 7 1.77142839251628 1.95683152466764 1 13.3824543971318 7 2788 2422 1892 1856 149 92 723 1223 1075 723 655 M15379 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. 95/148 Gene Ontology BP GO:1903426 3.50040509648232e-07 6.94934915072628e-07 1075 1161.63636363636 1075 3.18218695766321e-08 143 2.20546138720654 -2.36156075063483 -1 16.3222961578205 1050 143 1331 263 2286 1479 1678 576 1072 1825 1075 656 M14335 GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 18/39 Gene Ontology BP GO:0051350 4.2685980040768e-07 7.97341891327553e-07 1715 1245.90909090909 1076 3.88054439300097e-08 137 2.96009167241104 3.07275145220523 1 21.728709422138 1711 977 778 137 2443 869 886 2157 1076 1229 1442 657 M14391 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND.html The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. 24/35 Gene Ontology BP GO:0050910 0.000107648041232354 0.000115066927602605 165 1627.72727272727 1076 9.78666444652249e-06 164 2.79283066960939 2.82455771234185 1 13.2017411290085 164 2065 584 1016 4324 1076 1942 3217 1885 751 881 658 M14005 GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell. 77/145 Gene Ontology BP GO:0050715 1.05068929218931e-07 4.02645553947883e-07 1075 1664.63636363636 1077 9.55172129426149e-09 214 2.51166854845029 -2.9433017247418 -1 19.3227620556808 2747 214 520 1073 1077 3334 3469 1073 1743 378 2683 659 M15961 GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS.html The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 21/32 Gene Ontology BP GO:0021692 3.15775374344207e-08 3.85278716745714e-07 4325 2138.54545454545 1077 2.87068526251514e-09 70 2.74276660885803 -2.1682509459038 -1 21.1736335479943 4322 886 842 70 75 4255 3416 3951 1022 1077 3608 660 M15724 GO_LONG_CHAIN_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_TRANSPORT.html The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 37/73 Gene Ontology BP GO:0015909 8.25961395556169e-08 4.02645553947883e-07 785 1248.18181818182 1078 7.50874024150744e-09 176 2.12119646334776 -1.68227344748167 -1 16.3027770576341 785 645 1752 1573 778 843 176 1352 2767 1981 1078 661 M10469 GO_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_PRESSURE.html Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 166/298 Gene Ontology BP GO:0008217 4.32688451345297e-11 1.17736804918694e-09 940 1290.72727272727 1079 3.9335313759437e-12 118 2.521508466941 2.86209537168595 1 27.1263456473425 940 1727 118 1079 1349 1204 4218 637 2463 191 272 662 M13035 GO_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_GROWTH.html Any process that modulates the frequency, rate, extent or direction of cell growth. 432/558 Gene Ontology BP GO:0001558 4.2330031772357e-08 4.02645553947883e-07 1205 1031.36363636364 1079 3.84818478062054e-09 158 2.17337866579457 2.39265328900803 1 16.7063640861743 1203 1483 259 1257 158 821 2558 1079 1467 341 719 663 M15323 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. 12/25 Gene Ontology BP GO:0002689 6.78150976398928e-07 1.10407155114913e-06 3625 1964.36363636364 1079 6.16501077672143e-08 420 3.13968783364162 2.99126705805585 1 22.5165568885166 3621 1079 475 420 2813 3778 3594 1059 446 581 3742 664 M16435 GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity. 26/40 Gene Ontology BP GO:0035587 1.05209911957762e-07 4.02645553947883e-07 3135 1966.09090909091 1079 9.56453790810756e-09 406 2.97626986804662 3.45382312279951 1 22.9160765813151 3133 748 406 424 1079 3813 3853 4420 816 472 2463 665 M13518 GO_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_GROWTH.html The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. 77/100 Gene Ontology BP GO:0035265 6.62004700338408e-08 4.02645553947883e-07 2780 1670 1080 6.01822472962611e-09 179 2.58614711191742 2.96701780396978 1 19.8987933596541 2778 179 301 461 500 2690 4525 3582 1080 321 1953 666 M15518 GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 51/58 Gene Ontology BP GO:0061001 1.19291647023154e-07 4.10546590935448e-07 1235 1087.54545454545 1081 1.08446957719602e-08 299 2.21061325810652 2.39853506622529 1 16.9717802702835 1030 433 1231 1392 1232 1354 736 299 1058 1081 2117 667 M12361 GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. 34/51 Gene Ontology BP GO:0050850 4.51643206698919e-08 4.02645553947883e-07 3820 2044.90909090909 1084 4.10584741791645e-09 180 2.06552152377427 2.16511694950994 1 15.8721765392003 3818 620 1424 959 180 4040 4563 1084 584 773 4449 668 M13650 GO_MESODERM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_MORPHOGENESIS.html The process in which the anatomical structures of the mesoderm are generated and organized. 77/111 Gene Ontology BP GO:0048332 5.13527542580293e-08 4.02645553947883e-07 545 1299.18181818182 1085 4.66843231424669e-09 191 1.8526156140813 2.19801199221681 1 14.2255219439059 541 2441 1649 2305 262 450 858 1085 2111 2398 191 669 M10481 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. 15/19 Gene Ontology BP GO:2001028 2.41433289268059e-06 3.18150409222395e-06 570 1501.54545454545 1086 2.19485049293784e-07 491 1.92364549611912 2.07183382281989 1 12.6864024737459 567 1086 1709 2283 3496 687 491 1004 2528 1778 888 670 M14001 GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the Notch signaling pathway. 68/96 Gene Ontology BP GO:0008593 1.1597480627584e-07 4.08548528935279e-07 1935 1063 1086 1.05431647626861e-08 233 2.74800948269387 -2.32559182362934 -1 21.1296609843593 1934 248 255 695 1428 2007 1300 1779 728 233 1086 671 M15202 GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. 40/58 Gene Ontology BP GO:1901862 1.31536255398339e-07 4.19743364004444e-07 1090 1156.27272727273 1087 1.1957842114799e-08 217 2.44628770663414 2.77642447835 1 18.7636603771831 2001 559 1087 621 1355 792 1608 2410 982 1087 217 672 M10360 GO_BONE_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. 34/39 Gene Ontology BP GO:0061430 1.46618224917197e-06 2.05300812681227e-06 60 1527.72727272727 1088 1.33289384209534e-07 57 2.85815465352096 3.01407788703547 1 19.5570865169797 57 1975 323 972 4166 1088 1909 2267 2643 500 905 673 M12682 GO_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 97/115 Gene Ontology BP GO:0051983 6.46284327071879e-07 1.07207164843688e-06 175 1490.54545454545 1088 5.87531379025511e-08 173 1.67306131504808 1.86657356302657 1 11.9762629101227 173 2413 2965 1589 2761 591 408 824 1088 2698 886 674 M12097 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 29/35 Gene Ontology BP GO:0050650 8.16186640157738e-07 1.27740209776453e-06 80 1717.72727272727 1089 7.41988129961984e-08 79 2.69022347221507 2.86306181825478 1 19.0723947508732 79 2569 1089 4461 2930 234 177 540 3308 2502 1006 675 M13576 GO_SKIN_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. 89/111 Gene Ontology BP GO:0098773 1.0613721088837e-07 4.02645553947883e-07 1155 959.272727272727 1089 9.64883781898857e-09 110 2.62027063860075 3.26158866977399 1 20.1627111724654 1153 110 328 474 1089 1231 2148 1249 789 534 1447 676 M10483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. 35/50 Gene Ontology BP GO:0048662 6.99496698016518e-08 4.02645553947883e-07 4025 1794.63636363636 1090 6.35906109324754e-09 572 2.8860330497008 3.14448004514588 1 22.2181679520611 4023 685 817 1528 572 4192 3843 797 1193 1001 1090 677 M14928 GO_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. 84/111 Gene Ontology BP GO:0030510 6.41103212306126e-08 4.02645553947883e-07 1775 1470.27272727273 1091 5.82821119080501e-09 167 2.03656817093944 2.26333558706851 1 15.6482458293228 1998 167 897 1771 465 1774 3809 1091 2743 449 1009 678 M11583 GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 32/49 Gene Ontology BP GO:0051023 3.02586858673967e-06 3.90876361302045e-06 40 1660.54545454545 1092 2.75079340773785e-07 37 1.33871285745119 -1.33751229419776 -1 8.65272385228373 37 689 2868 2561 3577 356 492 652 3982 1960 1092 679 M12061 GO_GLYCEROLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. 316/425 Gene Ontology BP GO:0046486 1.06397928256255e-07 4.02645553947883e-07 630 1203.54545454545 1092 9.67253940017685e-09 88 1.85710255675227 -1.83852358982812 -1 14.2602248076199 629 1556 1839 1910 1092 88 861 676 2079 2220 289 680 M10482 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. 18/23 Gene Ontology BP GO:0045603 2.8299796905044e-06 3.67715596199859e-06 1125 1331 1096 2.57271211897072e-07 241 2.32820180277857 -2.24983379902811 -1 15.1990444361578 1121 952 1003 1140 3553 1768 1096 599 2459 709 241 681 M12946 GO_RESPONSE_TO_AMPHETAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMPHETAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. 27/46 Gene Ontology BP GO:0001975 1.11175350502125e-07 4.02645553947883e-07 1055 1158.45454545455 1098 1.01068505563898e-08 326 1.75105720565289 1.6734671910341 1 13.4400499944865 1051 763 1902 1156 1163 847 809 326 1098 2241 1387 682 M13685 GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of epidermis development. 38/47 Gene Ontology BP GO:0045684 1.00475706274157e-06 1.49556449550113e-06 2655 1422.45454545455 1098 9.13415928747464e-08 257 2.68742225103976 -2.04015919290075 -1 18.8298652376894 2652 576 803 894 3085 2079 1368 2048 257 1098 787 683 M14226 GO_MONOSACCHARIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSPORT.html The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 55/83 Gene Ontology BP GO:0015749 1.5859462168959e-07 4.44738738572283e-07 1575 1050.81818181818 1098 1.44176939202213e-08 206 2.59871524133658 -2.54079543750574 -1 19.8602816733404 1741 389 799 864 1571 1402 1287 628 206 1574 1098 684 M15805 GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-6 production. 110/195 Gene Ontology BP GO:0032675 1.51404715304955e-07 4.37569031250903e-07 625 1134.27272727273 1098 1.37640659749707e-08 63 1.99904418726603 -1.86992526194841 -1 15.2706942563566 624 63 1098 1786 1515 825 1140 914 2398 990 1124 685 M15773 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. 16/22 Gene Ontology BP GO:0055026 1.49473200936043e-07 4.36901586057683e-07 1380 1135.36363636364 1099 1.35884737356006e-08 142 2.78635516513038 3.28337669446511 1 21.3277444446735 1377 1018 1099 957 1491 1058 1749 1222 142 1546 830 686 M13964 GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. 18/36 Gene Ontology BP GO:0042430 1.2308740056801e-07 4.14338946095474e-07 3115 1725.36363636364 1100 1.1189764314055e-08 582 2.48549791002237 -2.76469627465165 -1 19.0829808060521 3112 955 1100 709 1264 3584 3994 753 582 713 2213 687 M15779 GO_LYMPH_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. 22/28 Gene Ontology BP GO:0001945 1.09018714435603e-06 1.59306681284276e-06 1840 1341.81818181818 1100 9.91079713261204e-08 113 2.40194007345332 2.46326945774604 1 16.7389723374113 1836 896 1279 1100 3150 1400 2057 910 1069 950 113 688 M12303 GO_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. 305/465 Gene Ontology BP GO:0019216 7.4981498758431e-08 4.02645553947883e-07 1340 1249.36363636364 1101 6.81650011945347e-09 645 2.05726082076148 -1.79028804572609 -1 15.8082866988666 1340 1565 970 1167 646 645 1101 2701 1857 803 948 689 M14847 GO_DETERMINATION_OF_ADULT_LIFESPAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETERMINATION_OF_ADULT_LIFESPAN.html The control of viability and duration in the adult phase of the life-cycle. 16/19 Gene Ontology BP GO:0008340 7.15839286523697e-07 1.14953625930237e-06 1010 1416.27272727273 1101 6.50763199495144e-08 190 2.82207342013331 3.00531766649731 1 20.1685263825658 1009 2677 1693 2076 2855 583 266 1101 190 2418 711 690 M15345 GO_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. 38/91 Gene Ontology BP GO:0048663 1.37051989484812e-07 4.2456917914303e-07 2555 1472.09090909091 1101 1.24592725475139e-08 246 2.63088089860531 2.9842745228964 1 20.1715106685841 2553 575 755 246 1400 2336 3465 646 900 1101 2216 691 M15911 GO_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. 339/435 Gene Ontology BP GO:0001525 2.37220617439268e-18 1.97104916597306e-16 705 1115.27272727273 1101 2.15655106762971e-19 29 2.47477871896842 2.58853657195904 1 46.9028682977488 703 1533 29 854 1595 701 1947 1331 2406 68 1101 692 M10876 GO_NEGATIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. 191/243 Gene Ontology BP GO:0030308 7.93991493807839e-08 4.02645553947883e-07 250 1045.63636363636 1105 7.21810474966735e-09 246 2.0321755518405 2.30144303960192 1 15.6142724819644 741 1697 1125 1766 720 250 1635 806 1411 1105 246 693 M14028 GO_NEURON_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_CELL_CELL_ADHESION.html The attachment of a neuron to another cell via adhesion molecules. 13/22 Gene Ontology BP GO:0007158 1.05625314416443e-06 1.55579166818521e-06 1240 1281.09090909091 1106 9.60230592079832e-08 252 3.47494157963484 3.27187844031948 1 24.3058605922 1239 1106 478 1895 3122 796 252 2000 522 734 1948 694 M15338 GO_GOLGI_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LOCALIZATION.html Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. 18/19 Gene Ontology BP GO:0051645 6.74920241604383e-08 4.02645553947883e-07 1110 1981.36363636364 1107 6.13563874827017e-09 448 1.02571629520827 -1.070107053209 -1 7.83012613158839 1107 3317 3780 3558 524 784 474 448 3327 3997 479 695 M16608 GO_POSITIVE_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELINATION.html Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 13/16 Gene Ontology BP GO:0031643 1.09806412396346e-07 4.02645553947883e-07 1110 1001.09090909091 1108 9.98240162518225e-09 126 4.25661222218154 4.80123534211046 1 32.8184866366613 1108 1153 875 934 1143 1310 1481 126 539 1822 521 696 M13531 GO_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SIZE.html Any process that modulates the size of a cell. 209/258 Gene Ontology BP GO:0008361 5.41347368064694e-08 4.02645553947883e-07 320 1080.72727272727 1111 4.92133983077695e-09 316 2.30591274357954 2.61348540248768 1 17.7314077241477 1199 1639 316 449 317 1222 2759 1187 1111 697 992 697 M10130 GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 57/102 Gene Ontology BP GO:0018958 1.07912035664151e-07 4.02645553947883e-07 4375 2058.09090909091 1112 9.81018554157608e-09 273 2.1541434020983 2.22074096440504 1 16.5575949167189 4373 332 809 698 1112 3957 4624 1265 1050 273 4146 698 M12387 GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT.html The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. 58/62 Gene Ontology BP GO:0006893 2.06962694494455e-08 3.07666906543993e-07 1115 1756.90909090909 1113 1.8814790585585e-09 14 1.48855698753548 -1.62259014127389 -1 11.6201694667429 1113 2865 3607 3449 14 961 1649 545 811 3739 573 699 M11676 GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION.html Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. 38/49 Gene Ontology BP GO:0097035 1.2847601501325e-07 4.17457330905484e-07 1635 1151.09090909091 1114 1.1679638410547e-08 75 2.73867076249908 -2.30814121888906 -1 21.0264753442693 1633 563 1046 85 1324 1630 888 1114 75 1791 2513 700 M11996 GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 108/157 Gene Ontology BP GO:0002224 3.29596181938531e-07 6.66639210726007e-07 760 1068 1114 2.99632937561337e-08 89 2.20311091228581 -2.42599012734036 -1 16.352892721518 757 89 1114 736 2244 1260 789 844 1288 1502 1125 701 M14835 GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). 36/87 Gene Ontology BP GO:0007193 7.24386105013261e-08 4.02645553947883e-07 1960 1415.81818181818 1114 6.58532844422604e-09 134 2.3993887135603 2.73921518841793 1 18.4543685651144 1960 621 938 2174 606 1964 4056 500 1507 1114 134 702 M10964 GO_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of dendrite morphogenesis. 103/125 Gene Ontology BP GO:0048814 1.97569280321938e-07 4.93246485651519e-07 1125 948.272727272727 1115 1.79608452785905e-08 90 2.10510740198555 2.29533646969334 1 15.9539418113918 932 90 1137 192 1783 782 1123 1121 1012 1115 1144 703 M16543 GO_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_PATTERNING.html The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. 35/52 Gene Ontology BP GO:0021532 1.68888130997266e-08 2.60210752824596e-07 1280 1204.90909090909 1115 1.53534665721613e-09 10 1.97908694470563 2.16107840851617 1 15.6574776404233 1279 670 2047 1205 10 297 693 2847 1115 2319 772 704 M10441 GO_DENDRITIC_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_MIGRATION.html The movement of a dendritic cell within or between different tissues and organs of the body. 13/48 Gene Ontology BP GO:0036336 5.81804022819293e-08 4.02645553947883e-07 2050 1337.72727272727 1117 5.28912762004976e-09 60 3.07233752459607 -3.32596932432005 -1 23.6590820166477 2047 1117 1073 487 379 2453 2380 727 60 1808 2184 705 M13507 GO_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASODILATION.html An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. 27/34 Gene Ontology BP GO:0042311 1.08128695573181e-07 4.02645553947883e-07 830 1457.72727272727 1117 9.82988189887655e-09 616 2.20239204040184 2.35621938464233 1 16.9307590157981 826 2060 1392 2455 1117 616 894 1855 3075 1054 691 706 M11732 GO_ANATOMICAL_STRUCTURE_ARRANGEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_ARRANGEMENT.html The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 32/39 Gene Ontology BP GO:0048532 2.15745142826403e-07 5.13521287170422e-07 330 1195.36363636364 1119 1.96131967257876e-08 116 2.45373740415544 2.93786393921588 1 18.5612335535649 328 2014 1119 1580 1882 448 627 116 3511 1350 174 707 M14070 GO_REGULATION_OF_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GASTRULATION.html Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. 49/69 Gene Ontology BP GO:0010470 1.79282442123092e-06 2.45209054438198e-06 120 1377.54545454545 1119 1.62984171112856e-07 116 2.62241396352308 2.82940340714467 1 17.6908542784599 116 2480 557 1421 3371 795 2093 1119 2050 661 490 708 M14774 GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. 262/403 Gene Ontology BP GO:0002831 1.84001264216555e-07 4.7749337740829e-07 375 1041 1119 1.67273890550781e-08 295 2.04036898485222 -1.91673951027286 -1 15.4949287259737 371 1593 978 1478 1710 335 535 1450 1587 1119 295 709 M13025 GO_CELL_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGGREGATION.html The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. 35/45 Gene Ontology BP GO:0098743 1.6594734155427e-05 1.8985812152742e-05 230 1592.45454545455 1120 1.50862357562187e-06 230 2.58191508728654 2.75776841440177 1 14.6404362548949 230 1964 433 985 4038 1120 2090 2561 2674 366 1056 710 M16064 GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. 14/29 Gene Ontology BP GO:0045346 4.21244745678873e-07 7.89070773608613e-07 760 1237.09090909091 1120 3.82949842124258e-08 125 1.78545748517766 -2.06233793169028 -1 13.0751677673764 756 1120 2356 1439 2436 608 240 201 1355 2972 125 711 M16140 GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 81/144 Gene Ontology BP GO:0002285 2.00360811716558e-07 4.95366023866707e-07 950 1121.90909090909 1120 1.82146209058218e-08 186 1.8399904124674 -1.85527993622247 -1 13.9275937280139 949 186 1585 1120 1804 1030 672 1209 1518 1089 1179 712 M16303 GO_PENTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. 13/18 Gene Ontology BP GO:0019321 1.82247038076978e-07 4.75067489172088e-07 380 1653.72727272727 1121 1.65679139249313e-08 377 1.32311462615872 -1.34106574879094 -1 10.0153169515373 377 1121 2908 2855 1704 540 503 403 3480 3218 1082 713 M16745 GO_CARTILAGE_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_CONDENSATION.html The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. 35/45 Gene Ontology BP GO:0001502 1.6594734155427e-05 1.8985812152742e-05 235 1593 1121 1.50862357562187e-06 231 2.58191508728654 2.75776841440177 1 14.6404362548949 231 1965 434 986 4039 1121 2091 2557 2675 367 1057 714 M12673 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that modulates the frequency, rate or extent of protein localization to the cell surface. 37/46 Gene Ontology BP GO:2000008 1.0825563923411e-07 4.02645553947883e-07 2505 1439.18181818182 1122 9.84142223282334e-09 144 2.10581955708758 -2.33903398149256 -1 16.1838491547344 2502 648 2113 245 1122 3397 1871 337 144 2532 920 715 M13018 GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. 18/28 Gene Ontology BP GO:0045672 4.18520967048687e-08 4.02645553947883e-07 775 1414.81818181818 1122 3.80473613645906e-09 152 2.73337189333327 -3.60978575547718 -1 21.0374576795371 771 2643 1178 2716 152 589 239 457 4170 1526 1122 716 M13633 GO_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIVISION.html Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. 289/381 Gene Ontology BP GO:0051302 8.07745829632467e-08 4.02645553947883e-07 775 1193 1122 7.3431441753585e-09 378 1.8986564589049 2.13223932412438 1 14.5816105504144 775 1570 1122 2368 748 378 774 1410 1865 831 1282 717 M15889 GO_SKIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_DEVELOPMENT.html The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. 246/353 Gene Ontology BP GO:0043588 1.00969685052776e-17 7.5776120088801e-16 2495 1268.63636363636 1122 9.17906227752505e-19 31 2.63445087972455 3.14371761739862 1 48.0723322546445 2491 1591 31 362 154 1751 4414 1470 1122 100 469 718 M11430 GO_RESPONSE_TO_AXON_INJURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AXON_INJURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. 53/74 Gene Ontology BP GO:0048678 1.08469460062988e-07 4.02645553947883e-07 375 1629.36363636364 1123 9.86086049190904e-09 87 2.69704507396723 2.95515850493557 1 20.7564991841728 3235 373 375 87 1123 2296 3016 3407 281 782 2948 719 M13352 GO_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULUS_DEVELOPMENT.html The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. 74/90 Gene Ontology BP GO:0032835 2.11608883246185e-13 7.94045269148789e-12 550 1225.54545454545 1123 1.92371712042005e-14 76 2.91288158775809 3.14352591730307 1 39.0010141882812 546 189 76 840 3030 1220 2747 2248 1123 108 1354 720 M12354 GO_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMOPOIESIS.html Any process that modulates the frequency, rate or extent of hemopoiesis. 319/511 Gene Ontology BP GO:1903706 1.23944178387608e-07 4.14338946095474e-07 1085 1575.81818181818 1124 1.12676532154917e-08 665 2.05612284959589 -2.17053139577584 -1 15.7685690277173 665 2774 1081 2892 1278 1003 1124 1019 3136 1083 1279 721 M16250 GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that increases the frequency, rate, or extent of monocyte chemotaxis. 14/23 Gene Ontology BP GO:0090026 1.08540660225149e-07 4.02645553947883e-07 1660 1194 1124 9.86733323456216e-09 514 3.00568636184835 3.01838967211999 1 23.1435893110741 1657 1066 651 906 1124 1717 1948 1266 514 636 1649 722 M12465 GO_EAR_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_DEVELOPMENT.html The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 227/339 Gene Ontology BP GO:0043583 2.24430232197923e-15 1.13508029393145e-13 1130 1087 1128 2.04027483816292e-16 54 2.53629001732009 2.75772937703178 1 39.6042258976586 1128 1608 54 366 1645 758 3373 1486 1217 186 136 723 M10443 GO_LYSOSOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_TRANSPORT.html The directed movement of substances into, out of or within a lysosome. 93/101 Gene Ontology BP GO:0007041 1.08801100119144e-07 4.02645553947883e-07 185 1727.72727272727 1129 9.89100959090068e-09 122 1.28673564223408 -1.28318036878428 -1 9.84889915606955 185 2426 3874 2098 1129 122 404 611 3269 4125 762 724 M14135 GO_DETECTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS.html The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. 51/106 Gene Ontology BP GO:0009583 6.87863624999974e-08 4.02645553947883e-07 3760 1897.90909090909 1130 6.25330587733709e-09 414 2.47479557766008 -2.31568978601103 -1 19.0375795218497 3760 414 909 1489 545 3895 4118 1130 932 1079 2606 725 M16576 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 203/279 Gene Ontology BP GO:0007178 1.08908140983572e-07 4.02645553947883e-07 635 1242.27272727273 1130 9.90074057953896e-09 235 2.09276400526003 2.30204021296628 1 16.0828750463034 632 2367 694 1291 1130 235 2180 1903 2187 796 250 726 M10213 GO_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 53/102 Gene Ontology BP GO:0051339 6.45053632734012e-08 4.02645553947883e-07 1785 1516.27272727273 1132 5.86412410588533e-09 445 2.38073396395497 2.59557443639981 1 18.3100892014933 1785 445 1085 1779 473 644 1791 3307 3189 1049 1132 727 M16190 GO_PROTEIN_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HYDROXYLATION.html The addition of a hydroxy group to a protein amino acid. 17/20 Gene Ontology BP GO:0018126 3.53938483949779e-06 4.51322489947471e-06 460 1512.90909090909 1132 3.21762775792082e-07 160 1.85280562005729 2.19336145754605 1 11.8751512121979 459 1041 2228 2649 3708 1132 1877 160 307 2600 481 728 M11529 GO_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 32/54 Gene Ontology BP GO:0006584 5.30515004369719e-08 4.02645553947883e-07 1245 1183.45454545455 1137 4.82286379238845e-09 291 1.87153645207776 2.15971297468518 1 14.3718592854979 1245 707 2002 1988 291 984 953 1603 1811 1137 297 729 M14527 GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros. 18/26 Gene Ontology BP GO:0072010 1.09298850324822e-07 4.02645553947883e-07 2695 1531.45454545455 1137 9.93625961408461e-09 195 2.64451365193671 2.9058025219525 1 20.3502112252869 2691 931 649 395 1137 1393 1643 2939 195 523 4350 730 M12536 GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of T cell death by apoptotic process. 32/41 Gene Ontology BP GO:0070232 1.39552106549887e-07 4.25515040482715e-07 2495 1382.54545454545 1138 1.26865559456422e-08 486 2.7551827618399 -2.78728083611959 -1 21.1262030386579 2494 683 780 944 1423 2797 2366 1143 486 1138 954 731 M10466 GO_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DEGRANULATION.html The regulated exocytosis of secretory granules by a leukocyte. 35/68 Gene Ontology BP GO:0043299 2.09904875045217e-07 5.06580593145951e-07 1770 1196.54545454545 1139 1.90822631884107e-08 406 1.79833822190438 -1.80321817804468 -1 13.5888364814982 927 623 1770 1139 1855 1253 659 406 449 2313 1768 732 M16390 GO_EPITHELIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. 17/23 Gene Ontology BP GO:0072148 1.67132299960184e-06 2.30351478588489e-06 3775 2089.09090909091 1139 1.51938569935851e-07 156 2.65924099443476 2.94224349718095 1 18.028038048547 3774 998 1139 211 3345 2896 4577 510 156 1062 4312 733 M13417 GO_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. 32/65 Gene Ontology BP GO:0042461 1.08328102784388e-06 1.58656173199797e-06 1080 1468.36363636364 1140 9.84801419320296e-08 242 2.58653755679944 2.64744634689202 1 18.0388922624003 1078 2535 1104 2194 3142 1020 1680 242 1505 1140 512 734 M11722 GO_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. 376/485 Gene Ontology BP GO:0016055 7.97141276220574e-08 4.02645553947883e-07 920 1304 1141 7.24673913730865e-09 439 1.7765409237368 2.11121155357184 1 13.6371458926163 916 1520 2433 951 730 455 1418 1141 1356 2985 439 735 M10805 GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION.html Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 24/28 Gene Ontology BP GO:0010544 5.11652291655447e-07 8.97706679137555e-07 1065 1565.54545454545 1142 4.6513855513642e-08 560 2.91271323264555 3.51854288115693 1 21.1978979099073 1061 864 560 1142 2606 1806 3439 1031 2965 584 1163 736 M11645 GO_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 33/62 Gene Ontology BP GO:0043330 1.58217089814191e-06 2.19232912121927e-06 420 1580.81818181818 1142 1.43833821453697e-07 257 2.03831301673018 -2.15436581865246 -1 13.8474471529878 416 2548 2460 2514 3326 416 257 539 1142 2982 789 737 M10238 GO_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_SECRETION.html The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. 32/54 Gene Ontology BP GO:0014047 2.48850937721705e-07 5.59143257290898e-07 1765 1262.45454545455 1143 2.26228150791136e-08 314 2.25301359372306 -1.98384498391253 -1 16.9337203250777 1765 725 1318 2382 2008 965 539 314 1077 1651 1143 738 M15740 GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. 32/54 Gene Ontology BP GO:0009712 5.30515004369719e-08 4.02645553947883e-07 1250 1195 1143 4.82286379238845e-09 292 1.87153645207776 2.15971297468518 1 14.3718592854979 1246 708 2003 1989 292 985 954 1715 1812 1143 298 739 M11688 GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle tissue development. 119/167 Gene Ontology BP GO:1901861 1.19693790628517e-07 4.10861475461767e-07 2190 1171.72727272727 1146 1.088125428551e-08 16 2.14135583754844 2.42237392592183 1 16.4359748552634 2186 16 745 231 1235 1146 2293 2202 644 793 1398 740 M10714 GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. 37/77 Gene Ontology BP GO:0002286 8.71762573603047e-08 4.02645553947883e-07 1980 1284.63636363636 1147 7.92511461951942e-09 350 1.87919036073441 -1.91347690283108 -1 14.431056063453 470 1970 1977 1977 847 659 350 1076 2237 1421 1147 741 M13904 GO_METANEPHRIC_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 26/42 Gene Ontology BP GO:0072210 6.28667005782174e-08 4.02645553947883e-07 1150 1375.72727272727 1147 5.71515476133473e-09 445 2.08639874720141 2.340639080583 1 16.0336449359341 1147 755 1136 1095 445 1270 2358 2857 2394 470 1206 742 M12937 GO_ENSHEATHMENT_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENSHEATHMENT_OF_NEURONS.html The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. 107/139 Gene Ontology BP GO:0007272 1.10091022759023e-07 4.02645553947883e-07 870 1843.90909090909 1148 1.00082752971026e-08 84 2.56770100201449 2.7295917655004 1 19.7561276549738 3337 84 441 870 1148 2936 4394 1622 866 611 3974 743 M10784 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. 36/48 Gene Ontology BP GO:0045197 5.68374014872126e-08 4.02645553947883e-07 2295 1394 1149 5.16703663232884e-09 56 2.41436090147084 2.86558932459535 1 18.5701662997102 2292 595 1180 147 354 2420 2154 3878 56 1109 1149 744 M13182 GO_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT.html Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. 107/139 Gene Ontology BP GO:0008366 1.10091022759023e-07 4.02645553947883e-07 3340 1831.18181818182 1149 1.00082752971026e-08 85 2.56770100201449 2.7295917655004 1 19.7561276549738 3338 85 442 871 1149 2937 4395 1472 867 612 3975 745 M10270 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 10/25 Gene Ontology BP GO:0044550 1.07389187729023e-07 4.02645553947883e-07 1150 1365.27272727273 1150 9.76265390645824e-09 30 2.26900326944382 -2.65015810173933 -1 17.4459428665346 2084 1150 1341 65 1105 2949 4078 190 30 1150 876 746 M15451 GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 558/721 Gene Ontology BP GO:0010720 1.93862342521822e-13 7.333670567106e-12 1155 1339.18181818182 1151 1.93862342521839e-14 75 2.20008167399003 2.42257608575911 1 29.5238935974822 1151 1417 4557 391 495 318 2385 1393 1872 75 677 747 M16412 GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. 13/15 Gene Ontology BP GO:0048711 1.72763504761234e-07 4.61728080214833e-07 860 1048.45454545455 1152 1.57057743934689e-08 164 2.08321806568412 -2.60040016335308 -1 15.8592306226055 858 1152 1813 1207 1660 957 558 164 1609 1386 169 748 M11810 GO_REGULATION_OF_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_FORMATION.html Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. 27/52 Gene Ontology BP GO:0003156 1.58487258133538e-07 4.44738738572283e-07 2435 1356.36363636364 1154 1.4407933595537e-08 82 2.3741888133877 -1.775118123545 -1 18.1354775171255 2433 770 1154 989 1569 1685 1057 2632 996 1553 82 749 M12173 GO_EMBRYO_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT.html The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. 893/1244 Gene Ontology BP GO:0009790 7.11034710792425e-08 4.02645553947883e-07 1155 1459.72727272727 1154 7.11034733543091e-09 219 2.05932207082548 2.18192355459043 1 15.8242287969269 1154 1364 4352 351 698 451 2795 2391 1536 219 746 750 M10903 GO_PHOSPHOLIPID_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 29/34 Gene Ontology BP GO:0046839 7.59335734670811e-07 1.20545519393493e-06 455 1604.63636363636 1155 6.90305451597859e-08 284 1.40453564699906 -1.44487526715975 -1 9.9510456762983 455 2563 3206 2253 2887 284 323 1155 387 3652 486 751 M16228 GO_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 927/1233 Gene Ontology BP GO:0060284 2.69055238863174e-20 2.84525915097806e-18 1295 1387.27272727273 1156 2.69055238863174e-21 22 2.21058067353049 2.3902249330966 1 46.8054279740994 1292 1347 4606 307 505 712 2595 1156 1634 22 1084 752 M16538 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. 89/230 Gene Ontology BP GO:0007187 5.72990523982834e-08 4.02645553947883e-07 1395 1105.72727272727 1156 5.20900489914895e-09 137 2.51621123244232 2.67558444138726 1 19.3578960333202 1394 137 330 1256 360 1156 3404 2080 1287 364 395 753 M11967 GO_SYNAPTIC_VESICLE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYCLE.html A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. 85/129 Gene Ontology BP GO:0099504 1.28087364064174e-07 4.17034908558357e-07 1890 1306.36363636364 1157 1.16443065019652e-08 124 1.97636768322711 -1.86038277623109 -1 15.146194295039 1889 124 910 1245 1318 918 1157 3492 461 815 2041 754 M12177 GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of leukocyte differentiation. 246/409 Gene Ontology BP GO:1902105 1.69119084137709e-07 4.56444952722019e-07 450 1505.63636363636 1157 1.53744633762077e-08 448 2.07289863339105 -2.21028649400983 -1 15.7926897718169 448 2782 1157 2429 1638 648 924 1125 3208 1263 940 755 M12755 GO_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE.html An immune response mediated through a body fluid. 112/484 Gene Ontology BP GO:0006959 1.11869914096412e-07 4.03733058669573e-07 485 1450.36363636364 1160 1.01699927077267e-08 64 2.61941479269392 -2.62043086344203 -1 20.152380991811 485 64 253 2828 2378 1160 1470 2713 2969 707 927 756 M12078 GO_VENTRAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. 35/71 Gene Ontology BP GO:0021517 7.01480047169165e-07 1.13307489517219e-06 735 1357.36363636364 1161 6.3770933712671e-08 141 2.64433468907953 2.64459467283971 1 18.9118284233576 733 2005 1161 2419 2836 1085 887 141 1426 1734 504 757 M13330 GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. 32/61 Gene Ontology BP GO:0006775 1.10977739640732e-07 4.02645553947883e-07 3485 1935.54545454545 1161 1.00888859308128e-08 533 3.0445499317561 2.66379884440412 1 23.4441675151757 3481 690 729 533 1161 3448 3406 3008 884 1139 2812 758 M13110 GO_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_PRODUCTION.html The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. 12/36 Gene Ontology BP GO:0032609 3.29455524499796e-07 6.66639210726007e-07 700 1061.90909090909 1162 2.9950506712418e-08 117 1.85388596523263 -1.97694514715735 -1 13.7444023841525 699 1162 1834 1390 2243 358 219 117 1425 2083 151 759 M12556 GO_MESENCHYMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. 148/195 Gene Ontology BP GO:0048762 3.62794584459243e-13 1.31881500116317e-11 745 1095.54545454545 1164 3.29813258599366e-14 80 2.56576724573188 2.6856324705272 1 33.6574607293481 745 1742 80 883 1664 685 1164 1755 1675 120 1538 760 M16905 GO_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_EFFECTOR_PROCESS.html Any process of the immune system that can potentially contribute to an immune response. 447/940 Gene Ontology BP GO:0002252 8.40877297510849e-08 4.02645553947883e-07 780 1329.81818181818 1164 7.64433936046008e-09 618 2.06476627404068 -1.95648614008663 -1 15.8663352948393 776 1485 618 2830 791 1172 1021 1164 2559 669 1543 761 M10035 GO_LACTATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSPORT.html The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 12/13 Gene Ontology BP GO:0015727 1.07990719846288e-07 4.02645553947883e-07 2325 1329.54545454545 1165 9.81733864974507e-09 205 3.04739651193596 2.85465521743438 1 23.4661835049658 2324 1165 851 2172 1113 1899 803 205 492 1592 2009 762 M13665 GO_LACTATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 12/13 Gene Ontology BP GO:0035873 1.07990719846288e-07 4.02645553947883e-07 2325 1328 1166 9.81733864974507e-09 171 3.04739651193596 2.85465521743438 1 23.4661835049658 2325 1166 852 2173 1114 1900 804 171 493 1600 2010 763 M13362 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 29/39 Gene Ontology BP GO:0098901 3.47443102107735e-08 3.99952679980378e-07 100 1221 1168 3.15857370540782e-09 97 2.54601559871206 2.63767284229916 1 19.5973821828016 1362 2542 1123 1279 97 1168 1737 989 98 1039 1997 764 M16246 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. 28/42 Gene Ontology BP GO:1901381 5.20364649954781e-07 9.11274639156791e-07 3500 1894.36363636364 1171 4.73058884578503e-08 430 2.72966175419113 2.85779269186059 1 19.8377238482495 3497 757 867 896 2611 2883 3601 1023 430 1171 3102 765 M10419 GO_ORGAN_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_REGENERATION.html The regrowth of a lost or destroyed organ. 92/128 Gene Ontology BP GO:0031100 1.37175290505668e-07 4.24585858868063e-07 1175 1169.63636363636 1172 1.24704817326253e-08 125 2.12070189447143 2.05824616435858 1 16.2398529254286 1295 125 1172 710 1401 889 931 1172 716 1787 2668 766 M10785 GO_LOOP_OF_HENLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOOP_OF_HENLE_DEVELOPMENT.html The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. 10/16 Gene Ontology BP GO:0072070 1.11931151017354e-07 4.03733058669573e-07 1175 1852.36363636364 1172 1.01755597011059e-08 48 2.57417023938377 -1.56665259032325 -1 19.8025151521948 3619 1173 1171 742 1172 4538 3782 261 48 1152 2718 767 M15466 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. 213/264 Gene Ontology BP GO:0031110 1.12346720598731e-07 4.0491811847087e-07 880 1243.09090909091 1174 1.02133387578097e-08 505 1.68205174717621 2.0156288210321 1 12.9013763522127 878 1633 2364 1495 1174 505 981 705 1325 1949 665 768 M10683 GO_AMIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSPORT.html The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 85/124 Gene Ontology BP GO:0042886 4.86531038502374e-08 4.02645553947883e-07 1175 1075.36363636364 1175 4.42300953874575e-09 171 2.65025589035957 -2.47758981874968 -1 20.3946227838947 1650 171 509 1474 227 1175 799 1309 1951 1173 1391 769 M13929 GO_PURINE_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOTIDE_TRANSPORT.html The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. 12/18 Gene Ontology BP GO:0015865 2.60271874514935e-07 5.69100109078005e-07 950 1325.90909090909 1177 2.36610823005916e-08 387 1.77348663745737 1.9032950662924 1 13.2912259434173 947 1177 2559 1951 2067 525 406 581 1899 2086 387 770 M16676 GO_STABILIZATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_STABILIZATION_OF_MEMBRANE_POTENTIAL.html The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 7/16 Gene Ontology BP GO:0030322 4.06363394904625e-07 7.67373732342215e-07 1170 1457.18181818182 1177 4.06363469213687e-08 23 3.48364749109924 -3.06337624457968 -1 25.6602052180146 1166 1251 4643 426 2481 1177 857 466 23 1916 1623 771 M16418 GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 30/30 Gene Ontology BP GO:0051984 1.95047605952357e-07 4.93024708629241e-07 790 1377.90909090909 1178 1.77316021131719e-08 288 1.97420176765605 2.18173366622514 1 14.9559134218036 790 761 2473 1178 1760 1013 288 1846 347 3224 1477 772 M10565 GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS.html The process in which the left cardiac ventricle is generated and organized. 12/18 Gene Ontology BP GO:0003214 1.49223668561888e-07 4.36901586057683e-07 1955 1126.45454545455 1180 1.35657889712338e-08 149 2.00526277648657 -2.22534377081523 -1 15.3201260995572 1953 1096 1460 235 1490 2358 777 149 428 1180 1265 773 M15001 GO_CONVERGENT_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONVERGENT_EXTENSION.html The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. 21/25 Gene Ontology BP GO:0060026 1.13844354889258e-07 4.06950048332718e-07 435 1160.90909090909 1181 1.03494873436738e-08 176 1.99915704216568 2.04264305658803 1 15.347735318864 432 2102 1962 1641 1181 176 283 2123 1148 1338 384 774 M12908 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. 44/56 Gene Ontology BP GO:1901021 1.11256236548734e-07 4.02645553947883e-07 1015 1196.36363636364 1182 1.01142038340978e-08 553 2.56219262540072 2.70000165906688 1 19.7135248278528 1015 1917 1039 1307 1165 895 1462 1182 1382 1243 553 775 M15696 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. 25/30 Gene Ontology BP GO:0015012 3.31164604116081e-07 6.6850711624821e-07 850 1328.09090909091 1183 3.01058776332808e-08 436 2.13103786158225 2.03102639278562 1 15.8114205909581 848 848 1466 2648 2249 1183 1607 436 613 1975 736 776 M15832 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of endothelial cell proliferation. 81/103 Gene Ontology BP GO:0001938 5.79024408755874e-07 9.88804473316968e-07 1240 1481.72727272727 1183 5.26385964682774e-08 447 2.19611622129025 2.2854800374288 1 15.8458915316931 1240 2438 1020 1183 2682 447 1530 1074 3278 740 667 777 M12038 GO_SPECIFICATION_OF_SYMMETRY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_SYMMETRY.html The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. 132/206 Gene Ontology BP GO:0009799 2.73648363201286e-08 3.62759496859141e-07 870 1098.09090909091 1185 2.48771242368253e-09 47 2.08453654021114 2.06043930659495 1 16.1334554466138 869 1815 1185 1948 47 351 1238 1332 1650 916 728 778 M16467 GO_DERMATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. 12/14 Gene Ontology BP GO:0030205 5.3388026562646e-06 6.59974727938342e-06 110 1584.72727272727 1186 4.8534687383028e-07 109 2.6486886716199 2.6486886716199 1 16.49173865432 109 1186 1480 3660 3740 341 193 829 2802 2091 1001 779 M11534 GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. 14/17 Gene Ontology BP GO:0072202 6.74194212345034e-07 1.09911801128685e-06 800 1309.81818181818 1187 6.12904017230209e-08 426 2.43344890972753 2.68827866964717 1 17.4342883407797 799 1116 1486 1497 2808 1187 1182 517 1354 2036 426 780 M11927 GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY.html Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 254/367 Gene Ontology BP GO:0050803 9.61985984539278e-14 3.73010065505105e-12 1540 1082.90909090909 1187 8.74532713217562e-15 72 2.45175621932832 2.78431523512928 1 33.7835759230168 1537 1588 72 437 168 848 3223 1253 1439 160 1187 781 M11945 GO_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_FORMATION.html The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 24/26 Gene Ontology BP GO:0003272 2.30535842507867e-07 5.32349019944965e-07 3295 1758.72727272727 1188 2.09578060604995e-08 352 2.75873641741608 2.87232650900519 1 20.8290136036813 3295 815 526 553 1951 3480 4341 1891 1188 954 352 782 M12716 GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 25/81 Gene Ontology BP GO:0070098 8.2294224006816e-07 1.28538108191915e-06 1190 1700.54545454545 1188 7.4812958900175e-08 389 3.15609562656061 -3.24509345071938 -1 22.3827122676784 1188 2583 440 2659 2936 1065 389 1818 3895 662 1071 783 M10804 GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 13/15 Gene Ontology BP GO:0044090 1.78909118228268e-06 2.4477039903444e-06 1190 1611.81818181818 1190 1.62644785201355e-07 51 1.43928903597075 -1.47075007613763 -1 9.66437435303585 1190 2246 2885 2238 3370 539 602 780 51 3604 225 784 M15370 GO_NEURAL_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_FORMATION.html The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. 124/142 Gene Ontology BP GO:0001841 1.03727902019591e-07 4.02645553947883e-07 990 1433.72727272727 1191 9.42980971911476e-09 31 1.79562864262584 1.90310843941082 1 13.7847739226116 990 31 2417 1619 1057 497 2178 2266 2460 1191 1065 785 M11535 GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. 18/36 Gene Ontology BP GO:1902932 1.30402268723897e-07 4.18739690741189e-07 2455 1342.09090909091 1192 1.18547524048482e-08 580 2.68687265341924 -2.89330166219273 -1 20.6225133612628 2451 1011 1388 620 1342 2923 871 862 580 1523 1192 786 M16089 GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. 106/204 Gene Ontology BP GO:0002698 1.25035040453127e-07 4.14431426073273e-07 445 1286.45454545455 1192 1.13668225053985e-08 79 1.9258920889195 -1.96488840696556 -1 14.7630721124947 442 79 1583 2384 1293 724 1192 368 3401 1909 776 787 M13520 GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of lymphocyte differentiation. 129/229 Gene Ontology BP GO:0045619 4.53848734213712e-07 8.29813403313878e-07 635 1623.81818181818 1193 4.12589843491281e-08 24 1.76241530271318 -1.70135908488473 -1 12.8584944676183 635 24 2383 2978 2495 453 1029 2244 3512 1193 916 788 M10919 GO_CHROMOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION.html Any process in which a chromosome is transported to, or maintained in, a specific location. 65/72 Gene Ontology BP GO:0050000 1.53145465670711e-07 4.39183276674602e-07 2930 1340.63636363636 1195 1.39223160301281e-08 251 1.56734272894797 1.89360573768648 1 11.9476622205356 484 310 2928 2014 1528 529 251 1491 1195 2926 1091 789 M15200 GO_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. 80/124 Gene Ontology BP GO:0019218 1.21462785364213e-07 4.12831512271501e-07 730 1373.72727272727 1196 1.10420720063834e-08 204 2.15341467688071 -1.76407060423313 -1 16.5237019699291 728 2436 1196 2494 1253 518 204 1132 2368 1831 951 790 M14009 GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. 27/32 Gene Ontology BP GO:0072498 5.21062424220475e-05 5.6939959133346e-05 35 1663.63636363636 1197 4.73704332557994e-06 34 2.87846606914017 3.12691330996096 1 14.6733231202611 34 2047 485 1010 4350 1197 2394 2254 2619 1055 855 791 M10494 GO_ENDOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. 72/73 Gene Ontology BP GO:0007032 1.15026790904519e-07 4.07839457749109e-07 15 1464.54545454545 1198 1.04569815380623e-08 4 1.28467312506545 -1.21380948115135 -1 9.82429895662314 15 1873 3764 3425 1198 4 29 67 1922 3805 8 792 M12415 GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. 43/50 Gene Ontology BP GO:0048745 1.54830859099239e-05 1.7805931472782e-05 125 1407.81818181818 1198 1.40756317066711e-06 125 2.90367227281134 3.19623342958716 1 16.5756034178503 125 1931 417 1018 4020 1082 2073 1661 1488 473 1198 793 M10587 GO_PROSTATE_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a prostate gland are generated and organized. 31/37 Gene Ontology BP GO:0060512 3.22328935319414e-07 6.56526363896802e-07 2320 1671.63636363636 1199 2.93026347768047e-08 641 2.41569408281687 2.8518862047461 1 17.9601502158702 2320 675 945 641 2227 956 1199 4054 771 1264 3336 794 M11241 GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that activates or increases the frequency, rate or extent of viral release from host cell. 18/18 Gene Ontology BP GO:1902188 1.15085580920821e-07 4.07839457749109e-07 535 2035.90909090909 1199 1.04623260855578e-08 433 1.19562451340202 -1.2353134373004 -1 9.13617960976992 535 3007 3436 3741 1199 1004 482 433 4130 3992 436 795 M14854 GO_PHARYNGEAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHARYNGEAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. 22/36 Gene Ontology BP GO:0060037 1.72767583380251e-06 2.37204947025173e-06 4430 2026.90909090909 1199 1.57061562778207e-07 319 2.83511184023664 3.32976723819533 1 19.183486988534 2673 875 811 1102 3357 2396 4426 4429 709 1199 319 796 M15416 GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 9/21 Gene Ontology BP GO:0009074 4.10715525249802e-08 4.02645553947883e-07 1550 1453.36363636364 1200 4.10715532840727e-09 181 2.57227849596237 -3.09199378925154 -1 19.7915308593991 1546 1200 4555 738 181 1924 2168 489 1071 1332 783 797 M10906 GO_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_SECRETION.html The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. 37/51 Gene Ontology BP GO:0030073 5.07151601169174e-08 4.02645553947883e-07 2200 1176.90909090909 1202 4.61046920782007e-09 255 2.29730968507627 -2.46712357708496 -1 17.6648700416642 2196 609 1202 757 255 1966 826 1021 1445 1422 1247 798 M13053 GO_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DIFFERENTIATION.html The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. 75/95 Gene Ontology BP GO:0002062 7.86319722552406e-07 1.24067333639754e-06 505 1350.36363636364 1203 7.14836366906741e-08 228 2.41927484975459 2.62092271928894 1 17.1782006269302 505 228 489 590 2902 1203 2136 2014 2876 585 1326 799 M13131 GO_ESTABLISHMENT_OF_TISSUE_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_TISSUE_POLARITY.html Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 23/29 Gene Ontology BP GO:0007164 3.51769751545965e-07 6.95537638350604e-07 1315 1266.27272727273 1203 3.19790734356656e-08 690 2.4032281725216 2.62690588117362 1 17.7940771962155 1313 892 1663 1647 2295 776 793 1203 998 1659 690 800 M13877 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS.html The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. 73/110 Gene Ontology BP GO:0017156 1.96875599000997e-07 4.93246485651519e-07 1375 1235.36363636364 1206 1.78977833290165e-08 219 1.91809376832403 -1.84732567159602 -1 14.5274781835985 1372 219 1206 869 1776 789 1035 2851 873 1296 1303 801 M10877 GO_MODIFIED_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSPORT.html The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 27/36 Gene Ontology BP GO:0072337 4.81695786910864e-07 8.61718760667532e-07 1955 1404.90909090909 1207 4.37905356708595e-08 389 2.60732770707476 -2.6499073676707 -1 19.0206248998395 1955 740 673 1051 2552 2154 2242 1207 389 678 1813 802 M13434 GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. 22/26 Gene Ontology BP GO:0001836 1.42117669194619e-06 1.99659877645702e-06 910 1469.90909090909 1207 1.29197964546556e-07 218 2.16265925818682 -2.6154140088494 -1 14.8047134513657 906 2616 2291 1811 3281 1207 494 218 454 2580 311 803 M10789 GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 11/25 Gene Ontology BP GO:0002281 9.51345669196103e-07 1.43534740556727e-06 725 1486.27272727273 1208 8.64860073260561e-08 641 2.08574576742651 -2.20994189770615 -1 14.6360911436818 724 1208 2295 817 3048 844 641 794 2695 1855 1428 804 M10933 GO_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. 125/161 Gene Ontology BP GO:0010469 8.10240619756944e-08 4.02645553947883e-07 755 1364.63636363636 1208 7.36582408724901e-09 2 2.23876789726875 2.57665897199407 1 17.2120967764739 1817 2 761 1334 753 1057 2314 2695 2318 752 1208 805 M12725 GO_RESPONSE_TO_INSULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSULIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 242/299 Gene Ontology BP GO:0032868 2.84962812996544e-08 3.70372058344391e-07 1095 1648.81818181818 1208 2.5905710607966e-09 54 1.68564223022981 -1.67601823731907 -1 13.0080885779081 1093 2359 2962 1143 54 952 1208 1228 3038 3168 932 806 M10768 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 58/104 Gene Ontology BP GO:0035725 1.76938102423352e-09 3.53344631148437e-08 4515 1940.90909090909 1212 1.60852820514234e-10 164 3.05141342752179 3.23519814606645 1 27.3969565169128 4515 315 164 835 1734 3360 4548 860 1212 260 3547 807 M10257 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 278/369 Gene Ontology BP GO:0090287 9.69097189944895e-08 4.02645553947883e-07 1715 1391.27272727273 1213 8.80997484212280e-09 344 2.23148529554797 2.39791023732517 1 17.1557717566259 1712 1583 344 1295 968 766 3295 1213 2638 525 965 808 M13978 GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 78/103 Gene Ontology BP GO:0061178 5.65588235187029e-08 4.02645553947883e-07 1635 1336.54545454545 1213 5.14171136115896e-09 196 2.18891204087196 2.37115815185886 1 16.8265021485159 1632 212 1213 196 350 1910 2785 2829 475 716 2384 809 M14914 GO_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 60/70 Gene Ontology BP GO:0010332 1.33447182767798e-07 4.20399283289481e-07 1215 1438.72727272727 1213 1.21315628056739e-08 310 1.86106650096767 1.965139381411 1 14.2487054114206 1213 382 2332 3716 1377 537 310 656 2086 2059 1158 810 M16492 GO_ISOPRENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 105/195 Gene Ontology BP GO:0006720 1.15516863080259e-07 4.08387002100415e-07 805 1636.36363636364 1214 1.05015335587073e-08 694 2.26688649022775 2.19073518683018 1 17.412713394251 804 2831 1214 2858 1202 700 694 2295 2961 981 1460 811 M12681 GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/33 Gene Ontology BP GO:0051953 2.49185765775163e-06 3.27438963047679e-06 1360 1466.09090909091 1216 2.26532770926364e-07 242 4.41753838669178 4.31633378192608 1 29.2002828843633 1357 1194 1108 1316 3509 1078 1864 1161 242 2082 1216 812 M15028 GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of B cell differentiation. 21/26 Gene Ontology BP GO:0045579 1.47637185363634e-07 4.36788789058922e-07 780 1273.72727272727 1217 1.34215632064767e-08 176 1.97317403381918 -2.01111566321772 -1 15.0735894537673 777 933 2172 1135 1475 1217 1283 176 2348 2070 425 813 M11761 GO_AXON_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_REGENERATION.html The regrowth of axons following their loss or damage. 26/34 Gene Ontology BP GO:0031103 2.07355263594632e-07 5.02774383275572e-07 4245 2062.36363636364 1218 1.88504802853058e-08 286 2.4052998372255 2.17725624186727 1 18.2195161298563 4242 788 1218 1070 1843 3426 4424 929 286 1176 3284 814 M16920 GO_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. 119/127 Gene Ontology BP GO:0007030 3.29170031598588e-08 3.93734744737334e-07 1220 1845.18181818182 1219 2.99245487748837e-09 80 1.28381901678533 -1.28843948934921 -1 9.8414318622476 1219 80 3941 4337 83 705 909 1589 2206 4371 857 815 M13098 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion. 11/17 Gene Ontology BP GO:2000778 5.80451137846621e-07 9.9076120821194e-07 840 1443.27272727273 1220 5.27682991812484e-08 308 1.85076670750657 2.01127884060685 1 13.3359388716784 840 1220 2486 1827 2684 757 445 424 2505 2380 308 816 M16913 GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 225/273 Gene Ontology BP GO:0010770 8.73910227296237e-08 4.02645553947883e-07 1225 1291.81818181818 1221 7.94463874555219e-09 412 2.17024085056443 2.48517732570352 1 16.6820956293928 1221 1625 412 588 851 1299 3232 1144 2033 439 1366 817 M11475 GO_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 604/850 Gene Ontology BP GO:0031175 5.54985403260175e-13 2.00181944292216e-11 1035 1372.90909090909 1222 5.54985403260313e-14 80 2.31631015780971 2.55990916253812 1 29.8673815892133 1035 1409 4306 323 650 1276 2916 593 1222 80 1292 818 M16687 GO_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a cell of a different type via adhesion molecules. 26/46 Gene Ontology BP GO:0034113 1.71348744275725e-07 4.59265960319672e-07 970 1405.81818181818 1222 1.557715978376e-08 643 2.37559105758081 2.51030450252639 1 18.1061439774703 968 2037 1222 1260 1653 1033 1106 2243 643 1179 2120 819 M12444 GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 658/835 Gene Ontology BP GO:0031344 3.0451471186298e-11 8.63967655060028e-10 1355 1320.81818181818 1223 3.04514711867153e-12 95 2.16502441774143 2.39041477035794 1 23.628688573643 1355 1394 4369 324 300 584 2373 1351 1161 95 1223 820 M16000 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 506/975 Gene Ontology BP GO:0050778 1.07295857163726e-07 4.02645553947883e-07 685 1677.90909090909 1225 1.07295862344307e-08 683 1.94945524013226 -1.95922989261035 -1 14.9744979374485 683 1461 4585 1984 1225 1219 1127 838 2924 1307 1104 821 M11518 GO_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_CHECKPOINT.html A cell cycle checkpoint that originates from the mitotic or meiotic spindle. 28/31 Gene Ontology BP GO:0031577 7.25101909198983e-07 1.16061203422871e-06 170 1473.54545454545 1226 6.59183771078836e-08 46 1.84687906337907 1.95530065054868 1 13.154220256733 166 3254 2779 2491 2863 107 46 196 1226 2712 369 822 M11440 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. 347/433 Gene Ontology BP GO:0030111 8.4946137018584e-08 4.02645553947883e-07 975 1263.45454545455 1227 7.72237639077402e-09 639 1.85715078109159 2.12566173932483 1 14.260597783786 971 1538 1648 639 804 709 2085 1227 1757 1777 743 823 M15189 GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. 123/198 Gene Ontology BP GO:0002761 1.0190606806539e-07 4.02645553947883e-07 725 1655.18181818182 1230 9.26418843507045e-09 525 2.36370550311847 -2.74437732137098 -1 18.1783878629646 723 3655 1118 2006 1036 1230 1047 525 3126 2468 1273 824 M12021 GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition. 80/93 Gene Ontology BP GO:1902749 1.18982741789956e-07 4.10397848442301e-07 370 1339.72727272727 1231 1.08166134749916e-08 367 1.99016556003326 2.37623119818589 1 15.2694248991308 367 1857 2379 1643 1231 737 872 842 1495 2427 887 825 M12059 GO_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 87/132 Gene Ontology BP GO:0043542 6.31171053228869e-07 1.05263043393331e-06 255 1283.72727272727 1232 5.73792031190317e-08 60 2.17161643957693 2.41031933038071 1 15.5966207953202 254 2432 1232 2296 2748 60 384 168 3007 1436 104 826 M13908 GO_NEUROGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROGENESIS.html Generation of cells within the nervous system. 1416/1999 Gene Ontology BP GO:0022008 2.3052199103011e-23 3.46006072342937e-21 1235 1421.27272727273 1233 2.30521991030111e-24 16 2.21460026122683 2.4433260713369 1 54.6981622606554 1233 1311 4459 286 610 787 2746 1508 1620 16 1058 827 M15496 GO_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION.html The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. 42/98 Gene Ontology BP GO:0001708 1.281114079519e-07 4.17034908558357e-07 2420 1128 1233 1.16464923101948e-08 178 2.54348467125344 3.07373859835787 1 19.5219252276391 2420 527 925 222 1319 1233 2171 1479 675 1259 178 828 M11191 GO_POSITIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_GROWTH.html Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 35/45 Gene Ontology BP GO:0060421 8.55484013954643e-08 4.02645553947883e-07 3315 1654.54545454545 1234 7.77712770200625e-09 121 2.48547726888283 2.31675431346583 1 19.1201937431403 3313 565 555 153 822 2299 2082 4275 121 1234 2781 829 M15087 GO_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 201/329 Gene Ontology BP GO:0016042 9.91733827083075e-08 4.02645553947883e-07 515 1481.72727272727 1234 9.01576247081145e-09 515 1.99263094393752 -2.00472869533595 -1 15.3084270011299 515 2789 2201 1928 991 612 1234 526 2408 2105 990 830 M15852 GO_POSITIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AUTOPHAGY.html Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 98/126 Gene Ontology BP GO:0010508 2.98633398489801e-07 6.22554302496884e-07 605 1598.27272727273 1237 2.71484944570035e-08 288 1.63399895958401 -1.71553059494871 -1 12.160703664725 604 2418 3378 1215 2173 386 1237 1217 1733 2932 288 831 M16391 GO_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSPORT.html The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 94/164 Gene Ontology BP GO:0006814 1.05123967167441e-09 2.17396364102268e-08 2480 1290.09090909091 1237 9.55672429251576e-11 112 2.91823912524891 -2.81741288089309 -1 26.9412592848996 2479 112 157 1237 2050 2489 1795 625 974 379 1894 832 M12910 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. 67/120 Gene Ontology BP GO:0002708 1.61420609356865e-06 2.23339308753343e-06 385 1573.09090909091 1239 1.46746116178306e-07 291 1.59572710227773 -1.49652867095445 -1 10.8027941466947 382 291 2531 2459 3332 407 396 2351 3263 1239 653 833 M13288 GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. 12/17 Gene Ontology BP GO:0030007 2.33415944868351e-07 5.37133724763818e-07 1400 1468.27272727273 1239 2.12196336030324e-08 540 2.67595465542038 2.51130218397301 1 20.1883291088976 1396 1118 988 540 1959 1239 1415 4327 557 851 1761 834 M10131 GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 44/65 Gene Ontology BP GO:0050854 7.19997611796672e-08 4.02645553947883e-07 2900 1878.90909090909 1241 6.54543304872867e-09 485 2.29089981416989 -2.41350900119272 -1 17.6152948870879 2897 493 1190 485 600 3108 2653 2874 1079 1241 4048 835 M10566 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. 31/40 Gene Ontology BP GO:0051154 1.16959834333545e-07 4.08625383150012e-07 2220 1433.45454545455 1242 1.06327127774133e-08 575 2.23885014413779 -2.75003173432231 -1 17.1953972816792 2217 719 1666 1193 1216 2717 1704 575 1242 1487 1032 836 M16573 GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. 24/31 Gene Ontology BP GO:0032331 3.68340138326778e-07 7.1545279562112e-07 645 1238.18181818182 1243 3.34854727270001e-08 47 2.36542633779983 2.78846780405107 1 17.4774901952787 641 2095 1601 2051 2641 342 719 47 1243 2166 74 837 M13277 GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. 34/50 Gene Ontology BP GO:0071825 1.15330247216637e-07 4.08387002100415e-07 4155 2050.27272727273 1244 1.04845684784161e-08 681 2.57464132075624 -1.83229773852211 -1 19.7906588463047 4155 681 1244 1106 1200 3562 2425 3117 910 1122 3031 838 M14163 GO_RESPONSE_TO_PROGESTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROGESTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. 51/72 Gene Ontology BP GO:0032570 1.09932695932267e-07 4.02645553947883e-07 1690 1556.72727272727 1244 9.99388194777634e-09 464 2.19903800911929 -2.13571710562301 -1 16.9048183031512 1687 464 1155 1553 1145 1149 1244 2567 3322 1080 1758 839 M12558 GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids with a chain length of less than C6. 18/26 Gene Ontology BP GO:0046459 6.66484072740405e-06 8.06130903022547e-06 430 1863.45454545455 1245 6.05896447131373e-07 298 1.28039187335319 -1.42242539100335 -1 7.78448605396345 429 2645 3276 3186 3819 652 298 731 440 3777 1245 840 M10737 GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN.html Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. 9/16 Gene Ontology BP GO:2000047 4.1505153525147e-06 5.22661649127223e-06 305 1637.45454545455 1247 4.15052310458504e-07 103 1.84759235932954 -1.84759235932954 -1 11.6990371090173 305 1247 4258 2040 3693 579 103 522 1374 3519 372 841 M11228 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. 91/151 Gene Ontology BP GO:0051153 3.71543798349546e-08 4.02645553947883e-07 3815 2019.54545454545 1248 3.3776709511301e-09 116 2.18938169076934 1.76032794611572 1 16.8301345096975 3812 140 1181 1121 116 4606 3991 3390 850 1248 1760 842 M11590 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 14/23 Gene Ontology BP GO:0010744 1.08969442467787e-07 4.02645553947883e-07 610 1542 1248 9.90631344229222e-09 609 2.43597868305926 -2.51069358955804 -1 18.7373623134046 609 2225 1418 2046 1131 1199 876 1248 3454 1205 1551 843 M13949 GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY.html The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. 16/43 Gene Ontology BP GO:0060397 5.37197774671486e-06 6.63723113527993e-06 300 1901.63636363636 1249 4.88362805827118e-07 193 1.88242736090248 -1.88242736090248 -1 11.6853204344297 298 4049 2976 1681 4188 886 363 193 1182 3853 1249 844 M11144 GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. 21/23 Gene Ontology BP GO:0061099 1.47047335415376e-06 2.05839726741199e-06 1135 1866 1250 1.33679485183148e-07 547 1.55122795694331 -1.36487088015673 -1 10.5651512559134 879 983 3249 2558 3292 1134 547 2061 1133 3440 1250 845 M13752 GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of chemokine production. 60/101 Gene Ontology BP GO:0032722 1.21109031388562e-07 4.11930060709781e-07 3965 2043.63636363636 1252 1.10099125505056e-08 397 2.60704197935565 2.25387305570224 1 20.0291821948522 3961 397 930 977 1252 4535 3752 759 1705 1238 2974 846 M15794 GO_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. 51/61 Gene Ontology BP GO:0030850 2.59720111132567e-07 5.68695377458746e-07 4165 1779.54545454545 1252 2.36109219812477e-08 401 2.23019600072776 2.41379087228471 1 16.7413376842269 4161 401 1008 636 2065 2622 3227 2446 780 1252 977 847 M12883 GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS.html The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 13/31 Gene Ontology BP GO:0009072 7.63023155555036e-08 4.02645553947883e-07 1095 1200.36363636364 1253 6.93657438198973e-09 293 2.56551206467836 -2.93480400808948 -1 19.7391979993877 1094 1147 1836 1512 665 1579 1253 293 1462 1379 984 848 M14257 GO_HEAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_DEVELOPMENT.html The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. 787/1144 Gene Ontology BP GO:0060322 1.37000748749925e-07 4.2456917914303e-07 585 1302.45454545455 1254 1.37000757196068e-08 163 2.18251133210043 2.46797771783851 1 16.7162213611609 582 1386 4484 1254 1508 223 1883 802 1655 387 163 849 M10669 GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epidermis development. 72/90 Gene Ontology BP GO:0045682 4.54173058324322e-07 8.29813403313878e-07 2375 1511 1255 4.12884683713527e-08 262 2.66451495035761 -1.88727781773673 -1 19.49286804854 2375 262 566 910 2497 1986 1110 3018 442 1255 2200 850 M11389 GO_RELAXATION_OF_CARDIAC_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_CARDIAC_MUSCLE.html The process in which the extent of cardiac muscle contraction is reduced. 21/30 Gene Ontology BP GO:0055119 1.99266179475941e-07 4.93878508235586e-07 1135 1416.45454545455 1256 1.81151088658712e-08 639 2.24429230729098 2.14313091101729 1 17.0140779651624 1134 2084 1471 1354 1799 773 1251 2978 1256 639 842 851 M11523 GO_POSITIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of STAT cascade. 62/133 Gene Ontology BP GO:1904894 1.96935818270916e-07 4.93246485651519e-07 2250 1523 1256 1.790325780908e-08 269 2.34130253162412 -2.63770718265083 -1 17.7555418065084 2248 361 1042 269 1777 3094 2599 691 2370 1046 1256 852 M15878 GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. 62/133 Gene Ontology BP GO:0046427 1.96935818270916e-07 4.93246485651519e-07 2250 1523.54545454545 1257 1.790325780908e-08 270 2.34130253162412 -2.63770718265083 -1 17.7555418065084 2249 362 1043 270 1778 3095 2600 687 2371 1047 1257 853 M12805 GO_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. 97/169 Gene Ontology BP GO:0030216 5.34900970102048e-08 4.02645553947883e-07 4130 1651.54545454545 1259 4.86273621006783e-09 102 2.78740727729408 3.49083050759661 1 21.4553775645976 4127 102 233 1259 302 3456 4372 1478 828 400 1610 854 M12157 GO_STARTLE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STARTLE_RESPONSE.html An action or movement due to the application of a sudden unexpected stimulus. 19/45 Gene Ontology BP GO:0001964 2.21341155696884e-07 5.1753788816965e-07 1135 1343 1261 2.01219252696306e-08 757 2.44767193279376 2.46979066766958 1 18.5050804967511 1131 2622 1261 1764 1922 1278 1370 968 881 819 757 855 M16943 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. 83/143 Gene Ontology BP GO:0002705 8.04197769123037e-07 1.26246026306663e-06 535 1538.81818181818 1262 7.31089148266557e-08 195 1.72378054155137 -1.65137702550128 -1 12.1944436529147 534 195 2230 2711 2918 565 576 1392 3609 935 1262 856 M14199 GO_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSSIFICATION.html The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. 327/459 Gene Ontology BP GO:0001503 9.17568225360961e-15 4.14509218699471e-13 730 1121.63636363636 1263 8.34152932146333e-16 62 2.47734919596712 2.52656252177244 1 36.9961422189825 729 1540 62 411 1263 638 2100 1785 2106 258 1446 857 M14605 GO_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/46 Gene Ontology BP GO:0051955 1.23290350276895e-07 4.14338946095474e-07 1705 1217.27272727273 1267 1.12082142896562e-08 590 2.97131483807044 2.85015294030857 1 22.8330759951804 1705 857 646 918 1267 1713 2200 1362 590 1314 818 858 M12541 GO_ARACHIDONIC_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_SECRETION.html The controlled release of arachidonic acid from a cell or a tissue. 8/14 Gene Ontology BP GO:0050482 6.42389277284758e-07 1.06751332400213e-06 630 1821.81818181818 1268 6.42389462983624e-08 87 2.13467608127449 -1.74039243016909 -1 15.3138211201658 627 1268 4373 3868 2845 381 87 256 3995 2196 144 859 M16553 GO_SIALYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLATION.html The covalent attachment of sialic acid to a substrate molecule. 12/21 Gene Ontology BP GO:0097503 3.18002169941448e-06 4.0965229699268e-06 890 1657.27272727273 1268 2.8909329963927e-07 854 2.51342214098444 2.88766377543281 1 16.2738235092201 889 1182 1330 2655 3588 1268 1757 1263 2582 854 862 860 M15723 GO_ARACHIDONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONATE_TRANSPORT.html The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/14 Gene Ontology BP GO:1903963 6.42389277284758e-07 1.06751332400213e-06 630 1842.90909090909 1269 6.42389462983624e-08 88 2.13467608127449 -1.74039243016909 -1 15.3138211201658 628 1269 4569 3869 2846 382 88 281 3996 2199 145 861 M16208 GO_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 89/135 Gene Ontology BP GO:0006970 1.21996676914066e-07 4.13739458951273e-07 4575 2092.90909090909 1269 1.10906076071956e-08 145 2.37267431703687 -1.79002305855484 -1 18.2138826197818 4573 145 585 899 1257 4414 3390 1817 865 1269 3808 862 M16923 GO_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSSIFICATION.html Any process that modulates the frequency, rate or extent of bone formation. 196/250 Gene Ontology BP GO:0030278 1.32200089418933e-09 2.6979255090627e-08 2250 1509.90909090909 1269 1.20181899543975e-10 159 2.38450744988346 2.40509182330911 1 21.7245664782947 2247 1658 159 866 497 1269 3984 2638 1229 361 1701 863 M10632 GO_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 70/93 Gene Ontology BP GO:0061035 3.67435188106699e-08 4.02645553947883e-07 1705 1309.72727272727 1270 3.34031994766777e-09 114 2.37296690519585 2.65313693120778 1 18.2500172992334 1703 271 671 755 114 1427 3882 1597 1863 1270 854 864 M11316 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. 13/16 Gene Ontology BP GO:0055022 2.14025829342194e-07 5.12011405619142e-07 975 1287.54545454545 1270 1.94568954694169e-08 107 2.95841719027437 3.71657890867975 1 22.4046224606927 1343 1123 1270 973 1872 974 1813 1277 107 2294 1117 865 M10101 GO_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 723/1049 Gene Ontology BP GO:0048666 1.26453014423891e-15 6.76305604729153e-14 1275 1464.09090909091 1271 1.26453014423891e-16 53 2.29197897160303 2.54399736314174 1 36.4027437026574 1271 1387 4223 309 553 1294 3271 1138 1339 53 1267 866 M13460 GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. 70/97 Gene Ontology BP GO:0042439 5.80658889919183e-07 9.9076120821194e-07 2450 1219 1271 5.27871857432676e-08 46 2.12017029159226 -2.12323424349174 -1 15.29214810898 139 2448 1631 1900 2685 46 149 194 2448 1271 498 867 M16411 GO_NEGATIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_GROWTH.html Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 13/16 Gene Ontology BP GO:0061117 2.14025829342194e-07 5.12011405619142e-07 975 1293 1271 1.94568954694169e-08 108 2.95841719027437 3.71657890867975 1 22.4046224606927 1344 1124 1271 974 1873 975 1814 1320 108 2302 1118 868 M14274 GO_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_SECRETION.html The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 40/87 Gene Ontology BP GO:0050663 4.76772795898317e-07 8.55845019629915e-07 640 1719.09090909091 1273 4.33429908383746e-08 480 2.13550261951282 -2.04028211904149 -1 15.5676705083974 636 1967 1629 3026 2543 1093 1024 480 3981 1273 1258 869 M14661 GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. 48/59 Gene Ontology BP GO:0050775 3.51476824829096e-07 6.95537638350604e-07 130 1314.90909090909 1273 3.19524437256198e-08 129 1.84648035216457 2.02431774827553 1 13.6479310505739 129 2496 2415 2119 2293 317 534 236 1273 2346 306 870 M16738 GO_V_D_J_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_V_D_J_RECOMBINATION.html The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). 14/17 Gene Ontology BP GO:0033151 1.75343111973831e-06 2.40315611197124e-06 1275 1933.81818181818 1273 1.59402956113571e-07 192 1.97644949064555 2.40567810485121 1 13.3287307291889 1273 3585 2805 3222 3364 1129 457 192 680 3725 840 871 M12819 GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 210/257 Gene Ontology BP GO:0051495 5.8613821115243e-08 4.02645553947883e-07 2380 1573.54545454545 1276 5.32852933426093e-09 216 1.99999803502785 2.33465633550364 1 15.3654054777506 2378 1643 1236 216 388 2419 4377 1276 896 1536 944 872 M15477 GO_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of organelle assembly. 168/202 Gene Ontology BP GO:1902115 6.41184925755066e-08 4.02645553947883e-07 1280 1591.18181818182 1278 5.82895404038411e-09 467 1.60116703960042 -1.50948721442058 -1 12.2807710854339 1278 1730 3150 1369 467 778 972 1794 874 4110 981 873 M14390 GO_CELL_FATE_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_DETERMINATION.html A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. 33/63 Gene Ontology BP GO:0001709 1.24051245492107e-07 4.14338946095474e-07 4595 2225.45454545455 1279 1.12773865897251e-08 638 2.61934922054303 -1.9264244677624 -1 20.1161995488795 4593 654 667 1101 1279 4540 3942 2211 638 694 4161 874 M14291 GO_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_CHEMOTAXIS.html The movement of a macrophage in response to an external stimulus. 11/17 Gene Ontology BP GO:0048246 4.93458215787113e-07 8.7702867763844e-07 1105 1650.27272727273 1281 4.48598478608568e-08 226 2.93575802272642 -3.65267155668684 -1 21.4023593039758 1105 3070 1281 2507 2573 613 226 300 3897 1865 716 875 M10744 GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 18/29 Gene Ontology BP GO:0072207 9.95094571592623e-07 1.48593550758038e-06 1325 1640.36363636364 1283 9.04631837899837e-08 710 2.30914672877031 2.47254835206172 1 16.1727575499398 1321 947 1076 1088 3077 1283 2632 2886 1898 710 1126 876 M14413 GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE.html The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein. 34/36 Gene Ontology BP GO:0072661 6.18215363744941e-08 4.02645553947883e-07 2000 1310.90909090909 1285 5.62013982833841e-09 276 2.36852119749354 -1.546004542314 -1 18.2156333545702 1997 641 1367 1285 433 967 377 3552 276 2205 1320 877 M10910 GO_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROTIC_CELL_DEATH.html A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. 41/55 Gene Ontology BP GO:0070265 5.26902685497672e-07 9.19954294791996e-07 200 1525.27272727273 1286 4.79002556083228e-08 69 2.27797413034962 -2.21485542622305 -1 16.5267204546032 196 3224 2129 2765 2619 220 69 1117 1286 2405 748 878 M13124 GO_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that modulates the frequency, rate, or extent of mast cell activation. 37/56 Gene Ontology BP GO:0033003 9.25276006228989e-08 4.02645553947883e-07 1290 1418.72727272727 1286 8.41160041040229e-09 453 1.6341562626888 -1.684593894158 -1 12.5359159795893 1286 642 2693 1571 911 811 453 1298 1279 2261 2401 879 M13868 GO_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 46/71 Gene Ontology BP GO:0098900 5.5437847626238e-08 4.02645553947883e-07 1640 1214.72727272727 1286 5.03980445665614e-09 163 2.67773979516896 2.82952770324002 1 20.6071885046691 1636 1908 700 1286 339 1593 2590 163 513 1020 1614 880 M16377 GO_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that modulates the extent to which blood vessels can be pervaded by fluid. 28/38 Gene Ontology BP GO:0043114 1.98549466500171e-07 4.93246485651519e-07 760 1232.45454545455 1287 1.80499531290195e-08 342 2.64172223941208 2.38388179165551 1 20.0470206566943 760 2937 1287 1744 1795 520 505 342 1316 1414 937 881 M10709 GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 271/326 Gene Ontology BP GO:0060828 1.48609122999534e-07 4.36901586057683e-07 895 1323.90909090909 1288 1.35099211852747e-08 802 1.91670617955196 2.2572024265314 1 14.6390104670657 895 1595 1288 992 1482 802 1857 987 1597 1948 1120 882 M14825 GO_BODY_FLUID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_FLUID_SECRETION.html The controlled release of a fluid by a cell or tissue in an animal. 75/126 Gene Ontology BP GO:0007589 1.41374522622679e-07 4.2854237685504e-07 1600 1298.09090909091 1288 1.28522301552335e-08 254 2.21390798332551 -2.44012664079816 -1 16.94734340438 1596 254 1175 1111 1433 1875 1288 1008 702 1829 2008 883 M13066 GO_MIDDLE_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDDLE_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). 19/30 Gene Ontology BP GO:0042474 6.28981001608698e-06 7.64936905511048e-06 400 1574.90909090909 1290 5.71802545341311e-07 349 2.92085194170829 2.97376723882685 1 17.9704841666629 397 2628 1290 2742 3798 816 600 349 1974 2114 616 884 M11317 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. 114/144 Gene Ontology BP GO:0097191 7.74949207320043e-08 4.02645553947883e-07 2605 1997.36363636364 1292 7.04499304197819e-09 694 1.65335941276252 -1.7633669183074 -1 12.6844367762108 976 3441 3379 2603 694 917 994 1292 2605 4040 1030 885 M15245 GO_LINOLEIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LINOLEIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 19/30 Gene Ontology BP GO:0043651 5.35722636890365e-07 9.32130335465133e-07 2090 1490.36363636364 1292 4.87020697585803e-08 616 2.46091985627835 -1.71711021756829 -1 17.8452663313544 2049 926 1022 1292 2627 2087 616 1883 983 820 2089 886 M10724 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 42/68 Gene Ontology BP GO:0051966 2.87464697719417e-07 6.05236759497035e-07 1465 1322.27272727273 1293 2.61331577528382e-08 420 2.68021200387577 2.99572868095258 1 20.0525661840773 1464 507 420 1085 2149 1391 2615 847 1293 746 2028 887 M11342 GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. 109/351 Gene Ontology BP GO:0002460 1.64511807581289e-07 4.51606749661201e-07 1610 1414.45454545455 1293 1.49556199893791e-08 762 2.2362378681315 -2.29494011699094 -1 17.0577434828904 1224 1826 882 762 1607 1610 1275 1532 2351 1293 1197 888 M15460 GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 15/21 Gene Ontology BP GO:0035413 2.07132537664711e-07 5.02496192780971e-07 1985 1236.18181818182 1293 1.88302324696801e-08 159 2.39271359550114 -2.40675627783606 -1 18.1243354556085 1982 1071 1293 585 1842 1585 580 2075 159 1372 1054 889 M10721 GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase C activity. 47/64 Gene Ontology BP GO:1900274 4.88444642307575e-07 8.69779150653329e-07 485 1738.90909090909 1294 4.44040682502028e-08 291 2.77371271291396 -3.02865682198627 -1 20.2274206881683 2577 485 482 796 2567 3649 3651 291 2774 562 1294 890 M15691 GO_POSITIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_STORAGE.html Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 24/29 Gene Ontology BP GO:0010884 3.42933772478389e-08 3.99952679980378e-07 25 983.727272727273 1295 3.11757979840005e-09 23 2.1762308394275 -2.17154280237904 -1 16.7360935552753 23 2069 1573 1721 93 120 47 1295 2024 1462 394 891 M10164 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 19/24 Gene Ontology BP GO:0051968 5.37753543858832e-07 9.33644492378785e-07 1300 1368.81818181818 1296 4.88866977548926e-08 221 3.37147941069853 3.83998817095205 1 24.4833751557482 1296 989 603 2236 2632 1190 1354 221 1918 1072 1546 892 M15074 GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 44/87 Gene Ontology BP GO:0002275 2.96174100033349e-07 6.18645295610645e-07 270 1214 1296 2.69249218096067e-08 270 1.79125311240179 -1.97559939584178 -1 13.3468701974978 270 526 2124 1642 2168 797 541 294 1483 2213 1296 893 M15769 GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to a muscle, across a synapse. 21/40 Gene Ontology BP GO:0007274 1.13578875560416e-07 4.06950048332718e-07 3145 1785.18181818182 1297 1.03253528567387e-08 833 2.37135371321034 -1.95966905202081 -1 18.2242960004988 3142 930 1153 2377 1180 1744 833 1297 1005 1339 4637 894 M10321 GO_REGULATION_OF_COLLATERAL_SPROUTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COLLATERAL_SPROUTING.html Any process that modulates the frequency, rate or extent of collateral sprouting. 25/35 Gene Ontology BP GO:0048670 3.51559523129109e-08 3.99952679980378e-07 2700 1856.18181818182 1298 3.19599571588203e-09 103 2.70293678257867 3.09797824549953 1 20.8115933895702 2696 795 931 182 103 3156 3688 3313 134 1298 4122 895 M12721 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. 28/58 Gene Ontology BP GO:0002686 9.4452462671109e-08 4.02645553947883e-07 3575 2126.27272727273 1298 8.58658788420281e-09 779 2.75381428376272 -2.80408145138566 -1 21.1955629955803 3571 779 973 1298 938 3546 3441 2966 834 1168 3875 896 M10713 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN.html The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. 25/37 Gene Ontology BP GO:0050965 4.64935653987893e-08 4.02645553947883e-07 1925 1468.63636363636 1299 4.22668785285075e-09 193 2.53449737617812 2.45479674695063 1 19.4993245293924 1925 843 1188 219 193 2303 2855 3000 209 1299 2121 897 M11734 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 71/88 Gene Ontology BP GO:0001837 6.52554920876094e-08 4.02645553947883e-07 2330 1538.90909090909 1299 5.9323176384719e-09 236 2.35337033966145 2.54981470445718 1 18.0984537529901 2326 236 427 589 489 2223 3037 3911 1299 386 2005 898 M15173 GO_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. 139/169 Gene Ontology BP GO:0001952 1.23548245036219e-07 4.14338946095474e-07 1305 1672.81818181818 1302 1.12316592704071e-08 678 2.10238160689786 2.23354596998876 1 16.125647452115 1302 2390 678 1840 1273 710 2585 2545 3050 745 1283 899 M15576 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. 25/37 Gene Ontology BP GO:0050961 4.64935653987893e-08 4.02645553947883e-07 1930 1473.18181818182 1302 4.22668785285075e-09 194 2.53449737617812 2.45479674695063 1 19.4993245293924 1926 844 1189 220 194 2304 2856 3038 210 1302 2122 900 M11095 GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. 14/24 Gene Ontology BP GO:0048172 1.26477083602978e-07 4.16747130248656e-07 2805 1775.36363636364 1303 1.14979173521903e-08 804 2.60489214478775 -2.23236009040358 -1 19.9966741776896 2805 1103 1193 1288 1303 2422 2288 3842 804 883 1598 901 M13575 GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. 106/151 Gene Ontology BP GO:1901343 2.41440110754869e-09 4.6041837514033e-08 215 1316.63636363636 1303 2.19491010018036e-10 173 2.66446235527935 2.70563797530933 1 23.5392528159009 215 1829 173 1303 2731 651 1734 1756 2391 462 1238 902 M16562 GO_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. 1469/2129 Gene Ontology BP GO:0009888 6.9986260210527e-37 1.62823034379791e-33 1360 1399.18181818182 1304 6.99862602105268e-38 2 2.37911984490072 2.56134932312344 1 94.2388120996226 1356 1304 4635 275 178 336 2665 2029 1685 2 926 903 M10912 GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. 28/42 Gene Ontology BP GO:0033006 1.49678412140196e-07 4.36901586057683e-07 815 1499.27272727273 1306 1.36071293021512e-08 341 1.57366673112047 -1.52987565326748 -1 12.0005900785713 813 817 3041 2760 1494 480 341 587 1815 3038 1306 904 M13858 GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. 57/69 Gene Ontology BP GO:0006687 4.16617786168375e-08 4.02645553947883e-07 1555 1317.27272727273 1306 3.78743449143579e-09 150 1.95074559950589 -1.82869940547638 -1 14.9844778210283 1554 375 2238 2190 150 1263 1306 954 1379 1175 1906 905 M15515 GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 34/58 Gene Ontology BP GO:0071470 2.83549904649185e-07 5.99980766863418e-07 1585 1316.81818181818 1306 2.57772673813541e-08 15 2.30318516231782 3.39585492124952 1 17.2278292122644 1585 661 1238 1306 2946 2039 1917 40 256 2482 15 906 M15731 GO_PHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 27/34 Gene Ontology BP GO:0009395 1.49177242990516e-07 4.36901586057683e-07 1310 1339.72727272727 1306 1.3561568464173e-08 368 2.82771606792219 -2.99999602902421 -1 21.6458636863859 1306 807 1417 1913 1489 1277 879 888 2457 1936 368 907 M11251 GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic hydroxy compound. 420/648 Gene Ontology BP GO:1901615 1.09238314317566e-07 4.02645553947883e-07 1100 1233.36363636364 1307 9.93075634015097e-09 479 2.06958166156174 -2.07100510780973 -1 15.9035784131778 1098 1492 535 1461 1136 870 1599 1307 1930 479 1660 908 M12708 GO_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of mast cell degranulation. 28/42 Gene Ontology BP GO:0043304 1.49678412140196e-07 4.36901586057683e-07 3045 1487.09090909091 1307 1.36071293021512e-08 342 1.57366673112047 -1.52987565326748 -1 12.0005900785713 814 818 3042 2761 1495 481 342 440 1816 3042 1307 909 M14824 GO_HEART_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_FORMATION.html The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. 18/21 Gene Ontology BP GO:0060347 7.07280902200422e-06 8.51261779083954e-06 1175 1632.45454545455 1307 6.4298470550669e-07 549 2.65152177652396 2.65533470875534 1 16.1550287265369 1173 2629 926 2187 3839 1307 2079 1330 1007 931 549 910 M10562 GO_REGULATION_OF_PODOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PODOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of podosome assembly. 22/27 Gene Ontology BP GO:0071801 8.10330140823764e-07 1.27037269044912e-06 1740 1427.09090909091 1308 7.3666403572213e-08 117 2.84229053352976 -2.82859001133331 -1 20.1645348761759 1736 904 1308 519 2922 2147 1235 546 117 2578 1686 911 M16095 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. 26/46 Gene Ontology BP GO:1903170 3.5080222985582e-07 6.95476257144921e-07 1065 1950 1308 3.18911168902907e-08 816 1.39376042670489 1.53979044104014 1 10.276553676638 1063 816 2944 3745 2291 1036 1223 1110 3111 2803 1308 912 M14525 GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. 41/57 Gene Ontology BP GO:0048635 1.54996302476586e-07 4.40859340231257e-07 1935 1229.36363636364 1310 1.40905739451382e-08 300 2.43063294958867 2.77642447835 1 18.580264322469 1932 547 1115 624 1543 785 1519 2500 1310 1348 300 913 M10281 GO_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGY.html Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 299/374 Gene Ontology BP GO:0010506 8.1487688373127e-08 4.02645553947883e-07 510 1771.63636363636 1312 7.40797194467449e-09 173 1.43567419032368 -1.410611316502 -1 11.0008180717158 510 1578 3947 3095 760 182 746 1312 3255 3930 173 914 M15954 GO_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 1400/2148 Gene Ontology BP GO:0048468 3.81380702189138e-29 2.95760734547676e-26 1315 1456.18181818182 1312 3.81380702189137e-30 5 2.26039370952599 2.46496454422872 1 69.686193201087 1318 1312 4583 279 407 1311 3031 856 1414 5 1502 915 M16660 GO_NUCLEAR_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 220/255 Gene Ontology BP GO:0098813 3.53035115193924e-07 6.96342683763175e-07 5 1366.09090909091 1312 3.20941065314237e-08 5 1.71536329996418 1.87737226407181 1 12.6704495185398 5 3127 2789 2355 2303 96 80 769 1539 1312 652 916 M15330 GO_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron. 879/1295 Gene Ontology BP GO:0030182 3.00177294592701e-15 1.50185478681703e-13 1315 1461.72727272727 1313 3.00177294592703e-16 55 2.29906114327142 2.56131643448778 1 35.5521516797659 1225 1360 4548 305 722 1313 3133 657 1447 55 1314 917 M11291 GO_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. 15/27 Gene Ontology BP GO:0055075 1.27862255277103e-07 4.17034908558357e-07 785 1768.27272727273 1314 1.16238420643961e-08 532 2.93968063501401 2.51130218397301 1 22.5788728603167 2522 1039 782 532 1314 2302 2576 3943 567 784 3090 918 M14792 GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neuron migration. 23/24 Gene Ontology BP GO:2001224 2.98330827735291e-06 3.85914190006203e-06 1315 1465.81818181818 1314 2.71210211170313e-07 191 2.28281706215438 2.73706478426903 1 14.84283657998 669 2099 1314 2227 3572 873 614 191 2475 1315 775 919 M12615 GO_CHLORIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_TRANSPORT.html The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 60/116 Gene Ontology BP GO:0006821 2.39841860048036e-07 5.46515266798977e-07 2440 1296.63636363636 1315 2.18038078359424e-08 279 2.42658342281729 -2.49289175256462 -1 18.275322915668 2439 312 669 350 1979 2403 1931 1315 279 1237 1349 920 M13623 GO_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that modulates the frequency, rate or extent of reproductive process. 121/184 Gene Ontology BP GO:2000241 6.45584042277193e-08 4.02645553947883e-07 1965 1591.09090909091 1315 5.86894601110622e-09 28 2.3039511474708 2.35505417084859 1 17.7162363686356 1961 28 398 913 475 1315 2054 4209 2246 493 3410 921 M10299 GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION.html The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 11/22 Gene Ontology BP GO:0086069 9.48917598680913e-08 4.02645553947883e-07 3300 1842 1316 8.62652399645649e-09 44 3.32636809782632 3.67170498478151 1 25.6238025420577 3296 1196 1316 488 943 2691 3577 972 44 2375 3364 922 M15035 GO_NEUROTRANSMITTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 23/41 Gene Ontology BP GO:0042133 2.29389036148948e-08 3.26596701964021e-07 1600 1381.90909090909 1316 2.08535489582487e-09 24 2.62584607938233 2.78747523815191 1 20.4945383146718 1597 2073 950 1290 24 2113 2138 617 2663 1316 420 923 M14457 GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 594/724 Gene Ontology BP GO:0051493 5.78302920975934e-08 4.02645553947883e-07 1370 1396.63636363636 1317 5.78302936025476e-09 91 1.90863322687808 2.15090395248738 1 14.6587727618952 1367 1414 4494 91 458 1366 2429 784 1317 530 1113 924 M15018 GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 54/83 Gene Ontology BP GO:0050810 7.23799537988185e-08 4.02645553947883e-07 690 1327.72727272727 1317 6.57999601637435e-09 205 2.21778627036935 -1.78398759897796 -1 17.0498209035286 686 2479 1317 2092 604 490 205 1455 2572 1966 739 925 M15894 GO_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. 46/67 Gene Ontology BP GO:0048806 5.33166276820158e-07 9.29147073424793e-07 445 1215.27272727273 1317 4.84696732756497e-08 315 2.4335582516935 2.7004447171693 1 17.6498073453457 444 1927 1350 1365 2623 315 613 1317 508 2161 745 926 M13210 GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. 17/17 Gene Ontology BP GO:2000303 1.7374232533253e-07 4.63279678952587e-07 1925 1414 1318 1.57947580957837e-08 250 2.02064293965373 -1.97582002024181 -1 15.3762023672142 1923 1024 2315 821 1665 1436 1318 931 250 3011 860 927 M13649 GO_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REGENERATION.html The regrowth of lost or destroyed tissues. 57/80 Gene Ontology BP GO:0042246 3.6610379776666e-08 4.02645553947883e-07 4380 1994.45454545455 1318 3.32821639871839e-09 112 2.53921321404034 2.48548927761289 1 19.535797711831 4377 356 683 218 112 2967 3932 4020 1318 876 3080 928 M13771 GO_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 30/44 Gene Ontology BP GO:0033198 1.33424233779511e-06 1.8933301609517e-06 1070 1414.18181818182 1318 1.21294831543528e-07 387 2.49804191701007 3.04237543562419 1 17.1862581917974 1067 787 1508 1782 3248 920 967 387 2181 1391 1318 929 M12516 GO_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_PROLIFERATION.html The expansion of a leukocyte population by cell division. 71/127 Gene Ontology BP GO:0070661 2.23587237638291e-08 3.2409295789725e-07 1655 1276.18181818182 1320 2.03261127191473e-09 20 2.03771992210442 -2.14837680157118 -1 15.8894327871279 1653 245 1203 945 20 1467 458 1698 3457 1320 1572 930 M15224 GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. 41/42 Gene Ontology BP GO:0061298 2.59683156191535e-05 2.91351397647036e-05 50 1579.36363636364 1320 2.36078383168173e-06 50 2.82804314174008 2.76784903594443 1 15.4097691712817 50 2504 445 1425 4160 661 1320 2988 2373 567 880 931 M11417 GO_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELINATION.html Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 46/53 Gene Ontology BP GO:0031641 1.43718398174403e-07 4.2919876049086e-07 2730 1482 1321 1.30653097784573e-08 603 2.90980977372491 3.52139817318687 1 22.3044570076082 2726 1937 1038 644 1459 2277 1321 603 1061 2160 1076 932 M12684 GO_PONS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PONS_DEVELOPMENT.html The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. 10/20 Gene Ontology BP GO:0021548 1.03437682801751e-06 1.52889306885816e-06 1130 1446.81818181818 1322 9.40343013047377e-08 77 2.15929166465642 2.45892860861322 1 15.0842017403204 1126 1222 2050 1381 3111 1322 2201 227 77 2690 508 933 M15850 GO_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEATH.html The process of cell death in a neuron. 58/89 Gene Ontology BP GO:0070997 7.50752359456864e-08 4.02645553947883e-07 2490 1562.45454545455 1322 6.82502168251246e-09 367 2.38399585775278 2.54274866123527 1 18.3353173053973 2486 367 1280 622 649 2257 2642 1322 701 2323 2538 934 M15005 GO_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 504/763 Gene Ontology BP GO:0043900 1.074262497919e-07 4.02645553947883e-07 990 1847.09090909091 1323 1.0742625498508e-08 987 1.93620206473644 -1.88708256300903 -1 14.8719953709428 987 2769 4529 1896 1226 1323 1233 1772 2482 1037 1064 935 M15299 GO_RETINA_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_HOMEOSTASIS.html A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. 68/134 Gene Ontology BP GO:0001895 3.06941145031476e-08 3.81870895142101e-07 2515 1403.18181818182 1323 2.79037408467164e-09 69 2.86426636383922 2.91871384569511 1 22.1295151075838 2512 300 480 1700 69 1447 2940 2331 1045 1288 1323 936 M11062 GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. 30/37 Gene Ontology BP GO:0035025 3.43457155311586e-05 3.81500631096875e-05 145 1683.09090909091 1325 3.12238652159121e-06 145 2.86665202457481 3.26174511798973 1 15.2156505680447 145 2546 466 996 4295 1325 2184 2404 2305 776 1072 937 M10512 GO_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 148/204 Gene Ontology BP GO:0051216 4.12252409884881e-08 4.02645553947883e-07 500 1329.09090909091 1327 3.74774925099978e-09 202 2.36867605773876 2.52378764153221 1 18.216831073012 500 1762 228 1327 2461 744 1768 1646 3138 202 844 938 M11657 GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 77/129 Gene Ontology BP GO:0045428 7.85059738335586e-07 1.23910548252221e-06 1335 1454.90909090909 1332 7.13690925891483e-08 523 2.3292068744889 -2.53673572242034 -1 16.53638170114 1332 1856 1166 648 2901 1732 2112 523 920 1788 1026 939 M13947 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. 26/38 Gene Ontology BP GO:0070229 1.13966772147792e-07 4.06950048332718e-07 2730 1679.18181818182 1332 1.03606161865111e-08 813 2.26447961439035 -2.462548666494 -1 17.3983084125716 2727 813 1332 953 1184 2524 1583 1922 1308 1178 2947 940 M13317 GO_GLYCOPROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 22/29 Gene Ontology BP GO:0006516 1.695664196312e-06 2.33360707052343e-06 2805 1660.18181818182 1334 1.54151409387048e-07 275 2.74417998509566 -1.47262555416871 -1 18.5884541793149 2801 924 1334 1319 3350 1989 607 865 275 1844 2954 941 M14159 GO_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 1127/1567 Gene Ontology BP GO:0009628 4.20675544008594e-08 4.02645553947883e-07 2375 1784.27272727273 1335 4.2067555197215e-09 176 2.10420774019804 2.3013191476648 1 16.1713830578949 2372 1335 4477 849 663 762 3366 1989 2497 176 1141 942 M14165 GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION.html Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. 39/46 Gene Ontology BP GO:0070570 8.05594153315553e-08 4.02645553947883e-07 3090 1630.18181818182 1335 7.32358348013394e-09 249 2.61454491806401 2.81979821344588 1 20.1184273663147 3087 602 1335 249 739 2790 3904 1459 516 1946 1305 943 M12991 GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. 34/68 Gene Ontology BP GO:0001914 1.08614704688093e-06 1.58975848038281e-06 2485 1636.54545454545 1336 9.87406893741433e-08 141 1.4740542439455 -1.46980268063123 -1 10.2344293868918 141 646 2551 2483 3145 441 272 465 4041 2481 1336 944 M13871 GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that activates or increases the frequency, rate, or extent of tissue remodeling. 22/31 Gene Ontology BP GO:0034105 4.82340521627369e-08 4.02645553947883e-07 1340 1746.63636363636 1336 4.38491392911344e-09 220 2.87060396794023 -2.95822214249403 -1 22.0988365139678 1336 3285 1055 2663 220 1730 844 1321 4029 1198 1532 945 M10637 GO_SEROTONIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. 12/21 Gene Ontology BP GO:0042428 1.54763824470495e-06 2.15152696522621e-06 1995 1481.63636363636 1337 1.40694484856917e-07 365 1.99180362765751 2.12652858407043 1 13.5487865137969 1993 1168 1900 1511 3315 1337 1093 1835 600 1181 365 946 M12965 GO_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 72/83 Gene Ontology BP GO:0061383 8.02390592931473e-08 4.02645553947883e-07 190 1365.63636363636 1337 7.2944602017864e-09 186 2.59896966013416 2.76441554451832 1 19.9979653740662 186 2440 241 1337 3692 607 2383 1525 1970 300 341 947 M14453 GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. 21/25 Gene Ontology BP GO:0045605 4.66199268298793e-06 5.83125052525345e-06 1865 1729.18181818182 1337 4.23818414744368e-07 231 2.89550230502181 -2.40347536501209 -1 18.2263648329274 1861 921 1054 1165 3695 2417 1735 3697 231 1337 908 948 M11295 GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 22/29 Gene Ontology BP GO:0010832 3.61006050939038e-07 7.05485575396616e-07 1140 1369.54545454545 1338 3.28187372888959e-08 319 2.49276618297122 -2.87084677895123 -1 18.442280572859 1136 2096 1556 1186 2325 1915 1338 319 963 1473 758 949 M15261 GO_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. 267/410 Gene Ontology BP GO:0050727 1.60408690571143e-08 2.51306948561457e-07 715 1457.72727272727 1338 1.45826083400666e-09 207 2.29305671881125 -2.20833384591697 -1 18.1997053122822 712 1598 207 2359 897 1338 1018 2037 3453 396 2020 950 M13111 GO_OPTIC_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPTIC_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. 18/26 Gene Ontology BP GO:0021554 6.94251814124613e-08 4.02645553947883e-07 1340 1333.90909090909 1339 6.31138032757318e-09 53 2.67426393058065 2.51945802081322 1 20.58030551018 1339 2170 1584 634 563 1937 2398 758 53 1956 1281 951 M12727 GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 53/61 Gene Ontology BP GO:0010660 5.50180332413574e-08 4.02645553947883e-07 3630 1800.72727272727 1340 5.00163951065993e-09 328 2.39174551446654 2.44846655674227 1 18.3952546169453 3627 388 779 633 328 2285 2768 3253 1340 901 3506 952 M14054 GO_VITAMIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORT.html The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 31/42 Gene Ontology BP GO:0051180 1.30371503421488e-07 4.18739690741189e-07 2360 1687.36363636364 1340 1.18519555588431e-08 378 2.59351068028178 -2.11030843766767 -1 19.9023560887215 2360 717 904 1253 1340 3356 2026 2078 378 1029 3120 953 M14813 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. 1093/1430 Gene Ontology BP GO:0022603 5.16399450927826e-15 2.40280664516718e-13 1525 1559.63636363636 1340 5.1639945092783e-16 61 2.18836245149298 2.39268280428319 1 33.295228381276 1523 1333 4517 329 408 1340 3147 921 1682 61 1895 954 M15735 GO_COLLECTING_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLECTING_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. 18/27 Gene Ontology BP GO:0072044 5.83470634763836e-08 4.02645553947883e-07 4010 1838 1340 5.3042786385299e-09 57 3.45099370622553 4.43052219571513 1 26.5876805812246 4010 1002 1340 213 384 3101 3423 870 57 1529 4289 955 M12884 GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. 52/73 Gene Ontology BP GO:0019935 1.30385684820176e-07 4.18739690741189e-07 1445 1567.54545454545 1341 1.18532447770585e-08 434 2.52465327707415 2.74531571103058 1 19.3712173603736 1445 434 793 1323 1341 2132 2670 3050 1162 721 2172 956 M11553 GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 233/320 Gene Ontology BP GO:0071229 7.46171191521360e-09 1.28590168672181e-07 1305 1520.45454545455 1342 6.78337449138306e-10 192 2.49640918844145 2.56049567151512 1 20.7013819643752 1305 1628 192 239 1934 1089 3181 3461 2032 322 1342 957 M10268 GO_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 951/1356 Gene Ontology BP GO:0060429 5.53159305637395e-25 1.16993193142309e-22 1940 1465.09090909091 1344 5.53159305637398e-26 2 2.39782629946223 2.66919455226518 1 63.4977261765481 1936 1344 4234 2 166 249 3055 2660 1561 13 896 958 M10396 GO_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or around a point. 80/126 Gene Ontology BP GO:0009798 7.66746811834751e-08 4.02645553947883e-07 3830 2294.63636363636 1344 6.97042580506826e-09 159 2.27999497397871 2.60034799935059 1 17.5309547894474 3829 213 989 159 675 3519 4551 4273 1344 1160 4529 959 M10386 GO_COGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COGNITION.html The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. 274/419 Gene Ontology BP GO:0050890 1.00845294918652e-07 4.02645553947883e-07 2350 1571.36363636364 1345 9.16775450375247e-09 627 2.05136806786819 2.29327186403876 1 15.7627110328615 2349 1582 682 1345 1019 1401 3961 1327 1771 627 1221 960 M10180 GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. 130/154 Gene Ontology BP GO:0002244 1.43597591021877e-07 4.29132685308152e-07 1055 1561.63636363636 1346 1.30543273086115e-08 12 2.20516322656979 2.77292781609304 1 16.8784017613666 1055 12 933 2708 1458 1138 1645 2878 2779 1346 1226 961 M15294 GO_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_FORMATION.html The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 44/51 Gene Ontology BP GO:0060343 1.22425577419716e-08 1.99176997109768e-07 45 1481.36363636364 1346 1.11295980091808e-09 41 2.83072891987338 2.89887251933148 1 22.8369362607037 41 2492 202 1346 4233 900 1639 2150 2259 283 750 962 M10948 GO_ROUNDABOUT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUNDABOUT_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 11/15 Gene Ontology BP GO:0035385 1.06053556299329e-05 1.24581468684872e-05 400 1640.36363636364 1347 9.64127886784274e-07 260 3.62098775093632 3.62098775093632 1 21.3750960384266 400 2274 1347 2724 4057 1106 1044 260 1023 2376 1433 963 M11118 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS.html A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. 15/27 Gene Ontology BP GO:0002087 1.71943433924272e-07 4.60329573101057e-07 190 1317.18181818182 1347 1.56312224875184e-08 25 2.23186195068569 2.23718279321177 1 17.0017368209017 188 2655 1810 1347 3542 230 450 25 1947 2228 67 964 M13049 GO_CILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 212/278 Gene Ontology BP GO:0044782 2.29895260095664e-08 3.26596701964021e-07 315 1744.63636363636 1348 2.08995693180018e-09 25 1.66749709124299 1.60215616388613 1 12.9771176577624 315 3640 3282 4304 25 31 214 1348 2934 2477 621 965 M14489 GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 61/109 Gene Ontology BP GO:0010830 2.78543757495832e-08 3.67156969866319e-07 1915 1298.45454545455 1348 2.53221600929543e-09 49 2.23208434509246 -2.45214330359595 -1 17.2685760104845 1915 335 1348 1515 49 2459 2370 1468 739 1135 950 966 M14099 GO_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. 961/1416 Gene Ontology BP GO:0006629 8.53303615439357e-08 4.02645553947883e-07 1095 1592.09090909091 1352 8.53303648205075e-09 781 1.90848237203824 -1.8831094780441 -1 14.6576060220165 1092 1352 4473 1888 927 788 1656 1255 1844 781 1457 967 M13471 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. 25/54 Gene Ontology BP GO:0046641 1.32908194214108e-06 1.88715846102607e-06 165 1608.54545454545 1357 1.20825704097962e-07 161 1.58533927461703 -1.58752223545143 -1 10.8720640373568 161 772 2102 2403 3246 846 1169 1025 2980 1633 1357 968 M14794 GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. 38/54 Gene Ontology BP GO:0048169 3.44928677903639e-08 3.99952679980378e-07 1680 1584.63636363636 1357 3.13571530283299e-09 94 2.21363626804243 2.18703595551459 1 17.0255260557134 1676 589 1357 655 94 1859 3736 3798 627 1100 1940 969 M10208 GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION.html The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. 17/25 Gene Ontology BP GO:0021889 1.00484129890388e-07 4.02645553947883e-07 2875 1882.18181818182 1358 9.13492131636008e-09 202 2.78930182249882 -2.3262418099249 -1 21.4700303357296 3506 948 785 628 1011 2874 2873 4612 202 1358 1907 970 M12679 GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary amino compound. 14/25 Gene Ontology BP GO:1901160 1.28875733985733e-07 4.18245386187413e-07 2150 1334.45454545455 1358 1.17159765032053e-08 466 2.00423668108971 2.13179961170817 1 15.3581733135632 2148 1092 1704 1504 1327 1358 1825 1675 695 885 466 971 M14989 GO_LYTIC_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. 63/73 Gene Ontology BP GO:0080171 2.07694800057773e-07 5.02811604926545e-07 1360 1844.72727272727 1358 1.88813472423239e-08 346 1.25200319418028 -1.03894241543629 -1 9.43418116177637 1358 346 3731 3927 1846 501 681 902 2944 3683 373 972 M12329 GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 17/22 Gene Ontology BP GO:0098911 2.49703219847117e-08 3.44536160746657e-07 1585 1263.36363636364 1359 2.27002929710259e-09 11 2.91740462305969 2.997612822423 1 22.6996256477263 1583 2141 1056 69 34 1267 1700 2128 11 1359 2549 973 M16410 GO_LYSOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. 63/73 Gene Ontology BP GO:0007040 2.07694800057773e-07 5.02811604926545e-07 1360 1867.09090909091 1359 1.88813472423239e-08 347 1.25200319418028 -1.03894241543629 -1 9.43418116177637 1359 347 3732 3928 1847 502 682 1137 2945 3685 374 974 M10116 GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of hepatocyte proliferation. 11/16 Gene Ontology BP GO:2000345 2.06919376335673e-06 2.7826469886991e-06 1150 1428.81818181818 1360 1.88108700865838e-07 433 2.2065934924426 -2.10640941278736 -1 14.7228296352108 1149 1197 1802 1360 3431 1426 433 819 1397 1854 849 975 M16296 GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. 22/35 Gene Ontology BP GO:0032925 1.32642380110383e-07 4.20399283289481e-07 3250 1847.63636363636 1361 1.20583989188779e-08 118 1.48911556721033 1.59738945821725 1 11.3803960149445 888 2977 3070 3247 1361 677 625 839 3248 3274 118 976 M16964 GO_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a higher concentration of a chemical. 42/52 Gene Ontology BP GO:0050918 4.45535385522095e-07 8.19721687953462e-07 2285 1536.63636363636 1361 4.05032250682001e-08 514 2.66350171311758 2.57031146133525 1 19.5025340178049 2285 514 595 542 2479 1361 2734 2515 1281 893 1704 977 M13145 GO_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other. 121/132 Gene Ontology BP GO:0007062 3.69842938510578e-07 7.16336250094093e-07 5 1350.09090909091 1362 3.36220909713679e-08 4 1.85288462100289 1.92113947295009 1 13.6669492834137 4 2820 2529 2360 2347 167 78 988 1362 1400 796 978 M11264 GO_CAMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 13/17 Gene Ontology BP GO:0006171 1.00326930909753e-06 1.49430604840936e-06 1365 1983.81818181818 1363 9.12063424200217e-08 793 2.72007995162563 2.84994543593838 1 19.0611406005888 1363 2708 1265 3655 3083 1314 1204 2739 2691 1007 793 979 M13117 GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 41/45 Gene Ontology BP GO:0010837 6.6498119640391e-07 1.09102874008018e-06 1600 1426.27272727273 1363 6.04528543094538e-08 99 2.58449484798771 3.22782449263183 1 18.5328655277715 1600 552 1066 1317 2791 2122 2507 99 384 1888 1363 980 M13214 GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS.html The process in which the right cardiac ventricle is generated and organized. 18/27 Gene Ontology BP GO:0003215 6.68464304482006e-07 1.09365837157341e-06 715 1713.18181818182 1364 6.07695006902945e-08 113 2.97086137121687 3.62226403673115 1 21.3150532661748 2583 956 767 1364 2799 2699 3302 113 713 711 2838 981 M12753 GO_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_INFLAMMATORY_RESPONSE.html Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. 68/158 Gene Ontology BP GO:0002526 1.74086693585941e-11 5.06265865784613e-10 2270 1173.09090909091 1365 1.58260630533926e-12 18 3.35557198150025 -3.18071540792033 -1 37.6207171592467 1390 250 109 18 1365 2268 1366 2865 738 267 2268 982 M16078 GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of B cell activation. 70/210 Gene Ontology BP GO:0050871 6.88599974982896e-08 4.02645553947883e-07 1370 1356.27272727273 1366 6.25999996850977e-09 298 2.12234436012572 -2.00013674478736 -1 16.3116551085397 1538 298 1366 1543 548 1409 1142 1246 3481 980 1368 983 M11744 GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. 36/82 Gene Ontology BP GO:0021515 2.22066110516309e-07 5.17979430590306e-07 1160 1559 1367 2.01878302664977e-08 659 2.48869102581449 2.47114713842373 1 18.815806927095 2088 659 1159 1159 1925 2141 2668 953 1367 1111 1919 984 M12782 GO_PHOSPHOLIPID_SCRAMBLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_SCRAMBLING.html The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). 15/21 Gene Ontology BP GO:0017121 7.96636883096568e-08 4.02645553947883e-07 3380 1620 1368 7.24215374494005e-09 29 2.87217168248243 -2.6330475255859 -1 22.1109615149072 3378 1047 1395 701 728 3236 2072 474 29 1368 3392 985 M12879 GO_REGULATION_OF_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXCRETION.html Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. 15/33 Gene Ontology BP GO:0044062 1.11233702838226e-07 4.02645553947883e-07 2300 1961.90909090909 1369 1.01121553147535e-08 1093 2.90755813789672 -3.59025114555982 -1 22.3846470575169 2299 1122 1102 3866 1164 2201 1117 1093 3662 1369 2586 986 M13346 GO_CARDIAC_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_FATE_COMMITMENT.html The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. 7/19 Gene Ontology BP GO:0060911 3.82110037966984e-09 6.91812453953454e-08 1155 1583 1369 3.82110038624021e-10 2 4.54566036656934 5.05481406945418 1 39.2592745906582 1155 2745 4422 920 2013 1829 1369 2 263 1911 784 987 M11139 GO_SECOND_MESSENGER_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECOND_MESSENGER_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. 176/251 Gene Ontology BP GO:0019932 1.1841137767161e-11 3.55463316326451e-10 1030 1361.36363636364 1371 1.0764670697477e-12 104 2.45494008309624 2.52661951020959 1 27.9517136829121 1029 1688 104 403 1371 742 2695 3148 2232 145 1418 988 M10809 GO_NEURON_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. 44/65 Gene Ontology BP GO:0042551 1.3327505324631e-07 4.20399283289481e-07 2510 1968.54545454545 1372 1.21159146654597e-08 365 2.41069175006847 2.69326683451511 1 18.4871549580073 2509 489 942 728 1372 3037 4545 3777 365 1242 2648 989 M16656 GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. 34/39 Gene Ontology BP GO:0014065 9.9133850562421e-08 4.02645553947883e-07 1275 1414.36363636364 1372 9.01216863904324e-09 658 2.25947927868227 -2.55097135509488 -1 17.3722825196909 1275 658 1372 807 990 1697 2297 1274 2140 1626 1422 990 M14014 GO_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYSTEM_PROCESS.html A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. 1143/2821 Gene Ontology BP GO:0003008 8.34996914734381e-32 1.29508021475302e-28 1715 1645.27272727273 1373 8.34996914734373e-33 3 2.39606242832413 2.56323089254316 1 80.7097927659049 1713 1329 4465 276 455 1157 3711 1885 1373 3 1731 991 M16048 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 27/29 Gene Ontology BP GO:0010662 1.97513655870879e-07 4.93246485651519e-07 3490 1784.54545454545 1374 1.79557885094042e-08 478 2.43047173678729 2.45606421560026 1 18.4356880899323 3486 771 1147 1374 1782 2657 3118 478 1315 1056 2446 992 M15116 GO_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 92/111 Gene Ontology BP GO:0034332 1.3331313308358e-07 4.20399283289481e-07 2760 1829.90909090909 1375 1.21193764692674e-08 121 2.62752321479301 2.79608853399748 1 20.1592564941922 2758 121 381 676 1375 3593 4007 2121 520 924 3653 993 M15138 GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. 37/55 Gene Ontology BP GO:0002053 4.17950140776267e-07 7.84794997995146e-07 1015 1421.09090909091 1375 3.79954745615766e-08 116 2.17816386436444 2.61004093882848 1 15.9798757804868 1013 1983 1743 665 2431 506 1375 2761 1351 1688 116 994 M16073 GO_POSITIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 350/563 Gene Ontology BP GO:0051047 2.93253458608751e-09 5.45803337162607e-08 1465 1188.09090909091 1376 2.66594053636044e-10 54 2.22105967998746 -2.10751205631728 -1 19.4064064984583 1463 1527 178 54 671 1376 1685 1098 2544 201 2272 995 M12081 GO_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSPORT.html The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 374/632 Gene Ontology BP GO:0006820 2.6393111342334e-13 9.74659897427622e-12 2125 1418.18181818182 1377 2.39937375839429e-14 78 2.30732710909364 -2.23473590937529 -1 30.623375359422 2122 1509 78 1233 1196 1423 1377 2937 1044 161 2520 996 M14542 GO_ICOSANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. 75/162 Gene Ontology BP GO:0006690 1.01384051426601e-07 4.02645553947883e-07 1490 1360.54545454545 1379 9.21673237261355e-09 229 2.25772025467705 -2.16417020761849 -1 17.3586778951617 1489 229 860 1482 1026 1379 896 2177 2745 670 2013 997 M10920 GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. 18/30 Gene Ontology BP GO:0044065 5.6028008510917e-06 6.89860607571572e-06 265 1490 1380 5.09346829086407e-07 115 2.08332886492832 2.07466298670136 1 12.9011566195407 261 2637 2196 1380 3781 324 418 202 2319 2757 115 998 M12407 GO_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. 27/55 Gene Ontology BP GO:0050433 1.34514456560381e-07 4.22331826164274e-07 2840 1832.18181818182 1380 1.22285877077264e-08 297 2.85487073407438 3.12665571459218 1 21.9055756774324 2837 2044 1010 1072 1380 3182 4586 496 297 1053 2197 999 M16181 GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acid derivative. 75/162 Gene Ontology BP GO:1901568 1.01384051426601e-07 4.02645553947883e-07 1490 1369.36363636364 1380 9.21673237261355e-09 230 2.25772025467705 -2.16417020761849 -1 17.3586778951617 1490 230 861 1483 1027 1380 897 2264 2746 671 2014 1000 M15639 GO_CELLULAR_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 25/29 Gene Ontology BP GO:0071305 1.34661404000112e-07 4.22508100345598e-07 4395 2038.72727272727 1381 1.22419465675182e-08 213 3.04256829058429 -3.10514438223197 -1 23.3518912997999 4395 811 438 687 1381 4348 2441 2762 213 663 4287 1001 M10604 GO_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION.html The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. 528/718 Gene Ontology BP GO:0051301 1.15692789239069e-07 4.0843592437738e-07 305 1502.36363636364 1382 1.15692795262239e-08 302 1.68592419394619 1.88061576263728 1 12.9236553606007 302 1439 4251 2826 1312 438 586 1483 1041 1466 1382 1002 M13011 GO_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a cell population. 767/1073 Gene Ontology BP GO:0008283 1.78754380174548e-09 3.55446209808621e-08 1635 1648.72727272727 1382 1.78754380318337e-10 136 2.08244908483662 2.23001717891897 1 18.6579806497612 1631 1382 4400 844 520 1107 3109 1047 2233 136 1727 1003 M12966 GO_PHOTORECEPTOR_CELL_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_MAINTENANCE.html Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. 37/52 Gene Ontology BP GO:0045494 3.63430519546169e-08 4.02645553947883e-07 1170 1453.36363636364 1384 3.30391386863532e-09 110 2.37048763665606 2.36040229336217 1 18.2308421671767 1169 647 1682 1919 110 884 2006 3158 1384 2260 768 1004 M13755 GO_ENDODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. 82/113 Gene Ontology BP GO:0007492 9.53098974449391e-08 4.02645553947883e-07 585 1484.27272727273 1384 8.66453650672908e-09 141 2.29226059050045 2.59203858191776 1 17.6258193887381 583 141 248 460 2133 1826 3151 3360 2750 291 1384 1005 M10259 GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING.html The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. 589/794 Gene Ontology BP GO:0009792 9.35615855179583e-08 4.02645553947883e-07 505 1520.81818181818 1385 9.3561589457155e-09 308 1.99302291960835 2.10842134764492 1 15.3114586151445 1385 1418 4233 505 1045 308 2666 2275 1604 504 786 1006 M14202 GO_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of endocytosis. 238/321 Gene Ontology BP GO:0030100 6.12115894791049e-08 4.02645553947883e-07 1285 1306.90909090909 1385 5.56469010747478e-09 422 2.14470613570618 -2.00572577664333 -1 16.4846053125598 1281 1609 695 456 422 1385 1397 2419 1692 537 2483 1007 M16054 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the rate of production of a cytokine. 203/317 Gene Ontology BP GO:0001818 1.25050875178783e-07 4.14431426073273e-07 1410 1457.63636363636 1385 1.13682620260762e-08 760 2.06642136986378 -2.10665919874975 -1 15.8478226579785 1407 1671 760 1487 1294 1113 1373 2261 2488 795 1385 1008 M15567 GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of leukocyte degranulation. 38/56 Gene Ontology BP GO:0043300 2.20853352870021e-07 5.1743738716224e-07 405 1404.90909090909 1386 2.00775795491842e-08 207 1.85304687235448 -1.93643709881829 -1 13.9847266508428 401 2525 2583 1841 1918 366 207 324 721 3182 1386 1009 M14192 GO_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REMODELING.html The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. 116/161 Gene Ontology BP GO:0048771 9.72429507064158e-11 2.47252158271559e-09 165 1679.63636363636 1388 8.84026824642857e-12 19 2.57998442207391 2.7220319451698 1 26.7523928703076 3200 19 127 104 164 3255 4411 1388 2808 165 2835 1010 M10613 GO_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 187/221 Gene Ontology BP GO:0051783 1.35941433728015e-07 4.23886744058351e-07 635 1303.63636363636 1389 1.23583129207318e-08 372 1.79695663926089 1.98866315658458 1 13.7465232490597 634 1700 2008 1554 1389 402 372 1286 2217 1434 1344 1011 M13125 GO_MIDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). 124/187 Gene Ontology BP GO:0030901 5.7185259800848e-07 9.80722115300793e-07 1085 1707 1389 5.19866133319904e-08 467 2.05388762075941 2.37522314457293 1 14.821839105122 1081 3155 1960 1389 2670 467 1194 1844 1068 3409 540 1012 M14083 GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of plasma membrane organization. 113/137 Gene Ontology BP GO:1903729 3.41761638581574e-08 3.99952679980378e-07 1855 1231.36363636364 1389 3.10692403537011e-09 45 1.85732365023841 -1.62052461107073 -1 14.2684810029663 1852 45 1713 581 91 2172 1578 1174 586 1389 2364 1013 M16232 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html The directed movement of a protein to a specific location in the plasma membrane. 116/130 Gene Ontology BP GO:0090002 3.0258118769346e-08 3.8051628819937e-07 2280 1365.90909090909 1389 2.75073810777334e-09 65 2.0309353911917 -1.76507843158391 -1 15.664979903498 2278 1817 1389 1261 65 1807 1339 1875 350 1706 1138 1014 M16939 GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of cell proliferation. 749/1017 Gene Ontology BP GO:0008285 7.80600850514142e-08 4.02645553947883e-07 1980 1775.63636363636 1389 7.80600877934338e-09 315 2.12039738289303 2.41993664143492 1 16.2965968181814 1976 1389 4653 1270 831 1126 3265 1509 2262 315 936 1015 M10951 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html The directed movement of a protein to a specific location. 1474/1849 Gene Ontology BP GO:0045184 6.50675983269491e-08 4.02645553947883e-07 1135 2361 1390 6.50676002321555e-09 596 1.51491026110416 -1.36355490386737 -1 11.6136448375482 1132 3870 4270 4279 596 760 1180 1390 2923 4526 1045 1016 M15823 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein. 16/25 Gene Ontology BP GO:0042523 9.48106810664863e-07 1.4337149788832e-06 775 1571.18181818182 1390 8.61915653871803e-08 347 2.56646460964488 -3.13592284711906 -1 18.0346539465101 773 3563 2010 824 3041 1390 1026 347 352 2422 1535 1017 M10367 GO_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_SECRETION.html The controlled release of acid by a cell or a tissue. 64/113 Gene Ontology BP GO:0046717 7.61338862193126e-08 4.02645553947883e-07 3255 1679 1391 6.92126262309323e-09 290 2.49523651117573 -2.03113665211484 -1 19.1956735698458 3254 290 299 1052 661 2621 1391 3338 2178 302 3083 1018 M13989 GO_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSPORT.html The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 176/297 Gene Ontology BP GO:0006816 5.0899581081046e-09 9.00516162623982e-08 1720 1297.90909090909 1392 4.62723465443712e-10 187 2.32451358998441 2.49849522076746 1 19.7038023187407 1717 1691 187 1246 216 1092 3062 1593 1783 298 1392 1019 M10152 GO_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of neurological system. 684/2079 Gene Ontology BP GO:0050877 1.7766451332225e-18 1.50304178270623e-16 1810 1602.54545454545 1393 1.7766451332225e-19 29 2.3359917232859 2.46879779444906 1 44.5993487108251 1810 1393 4229 296 775 905 3449 1344 1759 29 1639 1020 M16876 GO_CYTOSOLIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_TRANSPORT.html The directed movement of substances or organelles within the cytosol. 231/284 Gene Ontology BP GO:0016482 1.18685432061021e-07 4.09676049985113e-07 520 1693.63636363636 1395 1.07895853148959e-08 58 1.41138538345266 -1.28665104805924 -1 10.8001317428759 518 2362 3765 2868 1230 58 318 1872 1395 3937 307 1021 M11087 GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. 60/90 Gene Ontology BP GO:0046928 3.57391026007726e-07 7.01420683166559e-07 3470 2003.90909090909 1396 3.24900985514616e-08 351 2.05600492079463 2.34267970078305 1 15.1991819509587 3469 351 1753 1372 2314 3728 3833 1212 1272 1396 1343 1022 M13646 GO_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 461/645 Gene Ontology BP GO:0009314 1.08633389469581e-07 4.02645553947883e-07 1400 1327.36363636364 1397 9.8757631667063e-09 207 1.94700357481546 2.08153758960494 1 14.955536293942 1397 1477 1402 1790 1126 207 1866 1131 2882 1003 320 1023 M13064 GO_PREPULSE_INHIBITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREPULSE_INHIBITION.html The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. 11/22 Gene Ontology BP GO:0060134 7.51331848447987e-07 1.19356336320535e-06 2110 1765.81818181818 1398 6.8302918639892e-08 362 2.66616957669441 2.57937176104011 1 18.9960075455828 2109 2253 1398 1119 2885 1565 992 4047 362 1355 1339 1024 M12904 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune system process. 782/1372 Gene Ontology BP GO:0002684 1.02122453175265e-07 4.02645553947883e-07 1140 1873.63636363636 1402 1.02122457868314e-08 532 2.09297247230782 -2.07799617307072 -1 16.0844873699007 1138 1388 4393 1917 1173 1302 1411 2680 3274 532 1402 1025 M14536 GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/28 Gene Ontology BP GO:0010829 9.20852569893851e-08 4.02645553947883e-07 1540 1111.63636363636 1402 8.37138734943563e-09 338 2.1373375229507 -2.25511713529516 -1 16.427615067093 1539 838 1624 1402 908 1483 428 359 1848 1461 338 1026 M12087 GO_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION.html The attachment of one cell to another cell via adhesion molecules. 571/888 Gene Ontology BP GO:0098609 8.06069033213119e-25 1.63071270066984e-22 2320 1714.09090909091 1403 8.06069033213123e-26 1 2.50645241361034 2.73816420799112 1 65.9417945995365 2319 1403 4343 1 243 1153 3581 3025 1126 14 1647 1027 M15129 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 4/21 Gene Ontology BP GO:0033139 4.77674067683415e-08 4.02645553947883e-07 3690 1798.09090909091 1403 4.77674077951178e-09 36 4.88335696033024 -5.96392799868506 -1 37.6658490449543 3687 1284 4536 121 277 3865 2159 1614 36 1403 797 1028 M15765 GO_VESICLE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING.html The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. 54/63 Gene Ontology BP GO:0048278 1.3733179171269e-07 4.24587924810065e-07 1350 2115 1403 1.24847091168571e-08 245 1.37801216431722 -1.10444054668465 -1 10.516443526252 588 2871 3459 3886 1403 683 245 1346 3501 3936 1347 1029 M10296 GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that modulates the frequency, rate or extent of protein activation cascade. 28/46 Gene Ontology BP GO:2000257 8.5449687703369e-08 4.02645553947883e-07 855 1895.90909090909 1404 7.76815372930006e-09 349 2.95714056731231 -3.22549966333116 -1 22.7681269494596 853 3520 1404 3859 819 1458 870 492 4194 3037 349 1030 M11198 GO_HEXOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. 13/22 Gene Ontology BP GO:0035428 5.04940604495537e-07 8.90632537042356e-07 4310 1833.09090909091 1404 4.5903701853524e-08 18 3.88250307634734 -3.69600323284535 -1 28.3061654740918 4308 2201 462 836 2589 3442 1404 1126 18 1006 2772 1031 M15888 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 4/21 Gene Ontology BP GO:0033141 4.77674067683415e-08 4.02645553947883e-07 3690 1802.54545454545 1404 4.77674077951178e-09 37 4.88335696033024 -5.96392799868506 -1 37.6658490449543 3688 1285 4579 122 278 3866 2160 1611 37 1404 798 1032 M13216 GO_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. 61/90 Gene Ontology BP GO:0048546 1.37880582092966e-07 4.24835370983751e-07 2885 1771.18181818182 1405 1.25345991576686e-08 250 2.22407676387392 2.53308548804808 1 17.0358066294732 2882 277 589 625 1405 2555 3996 3252 322 250 3330 1033 M13957 GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of glucose across a membrane. 13/22 Gene Ontology BP GO:1904659 5.04940604495537e-07 8.90632537042356e-07 4310 1835 1405 4.5903701853524e-08 19 3.88250307634734 -3.69600323284535 -1 28.3061654740918 4309 2202 463 837 2590 3443 1405 1136 19 1008 2773 1034 M13556 GO_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSPORT.html The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 298/504 Gene Ontology BP GO:0015711 1.877618725582e-09 3.70193217378519e-08 2255 1503.45454545455 1407 1.70692611562225e-10 166 2.26580441274058 -2.11779213681635 -1 20.261464341726 2255 1551 166 2158 1103 1319 1297 2385 1407 243 2654 1035 M12588 GO_REGULATION_OF_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESODERM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of mesoderm development. 16/28 Gene Ontology BP GO:2000380 9.31488732809766e-07 1.41641080841956e-06 1415 1770.36363636364 1412 8.46808297460023e-08 272 2.20663937451899 2.81308562962644 1 15.5057856894764 1412 1081 1961 2334 3024 1349 1017 1408 272 3583 2033 1036 M15680 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 103/201 Gene Ontology BP GO:0070588 3.87927275454598e-08 4.02645553947883e-07 1550 1183.18181818182 1412 3.52661165722676e-09 56 2.47048684697327 2.89069554981687 1 19.0042549833456 1672 56 244 1692 131 1548 3362 1412 1546 389 963 1037 M11140 GO_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING.html Any process that mediates the transfer of information from one cell to another. 571/1050 Gene Ontology BP GO:0007267 8.95856742319139e-22 1.12660038432728e-19 1985 1695.09090909091 1413 8.9585674231914e-23 20 2.5056617464006 2.78336201115977 1 57.3166342495081 1981 1413 4279 668 617 828 4080 1831 1781 20 1148 1038 M14213 GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 90/160 Gene Ontology BP GO:0042035 4.03262508747144e-07 7.62756281788806e-07 895 1755 1413 3.66602347877855e-08 768 2.12401833644856 -2.0728360965737 -1 15.6118602570901 892 3179 1257 2264 2411 1624 1302 768 3259 936 1413 1039 M14909 GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. 44/58 Gene Ontology BP GO:0031952 5.01241119806102e-07 8.86459494662788e-07 1025 1452 1413 4.55673849097589e-08 541 2.03860250726058 2.30672590403185 1 14.8189708920161 1021 541 1930 1651 2584 919 1058 1615 1413 2212 1028 1040 M11091 GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme adenylate cyclase. 25/45 Gene Ontology BP GO:0007190 6.35117305786977e-08 4.02645553947883e-07 1415 1775.81818181818 1414 5.77379385565601e-09 453 2.02722609065766 2.17887092172176 1 15.5759924125539 1414 861 2133 2281 453 945 936 4418 3236 1968 889 1041 M13981 GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphatidylinositol. 21/23 Gene Ontology BP GO:0046856 5.2102128071668e-06 6.4527868490144e-06 350 1874.54545454545 1416 4.73656831494812e-07 316 1.06303227559937 -1.15369136545529 -1 6.56977849453747 346 2985 3632 2130 3733 544 316 805 1416 3948 765 1042 M14311 GO_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PIGMENTATION.html The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. 44/53 Gene Ontology BP GO:0048066 3.0965893153538e-07 6.39656754858952e-07 405 1261.45454545455 1416 2.81508159201037e-08 405 2.21751339956396 -1.95238655607425 -1 16.5085930661741 1189 538 1558 1529 2194 840 405 1416 2130 1672 405 1043 M12147 GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. 20/22 Gene Ontology BP GO:0045540 1.79661486661127e-07 4.72066258868601e-07 1420 1517.36363636364 1417 1.6332863757551e-08 518 1.79740689467548 -1.52783848741601 -1 13.6483624852608 1417 2135 2566 809 1687 1392 518 872 1006 2645 1644 1044 M16723 GO_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_TRANSPORT.html The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 65/102 Gene Ontology BP GO:0015833 5.54514180757051e-08 4.02645553947883e-07 1780 1260 1417 5.0410381339426e-09 305 2.36609460424639 -2.3623083596682 -1 18.1968656231949 1778 305 997 1493 340 1623 1038 1768 1326 1417 1775 1045 M13948 GO_OOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. 40/71 Gene Ontology BP GO:0009994 8.57241863350437e-08 4.02645553947883e-07 3035 1936.72727272727 1418 7.79310815230303e-09 524 2.25763022774208 2.35453959665193 1 17.3579816098102 3035 524 796 744 829 2944 4059 3007 1418 1086 2862 1046 M15739 GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 28/55 Gene Ontology BP GO:0010866 9.70809480282734e-08 4.02645553947883e-07 1420 1832.45454545455 1420 8.82554111929391e-09 970 1.86003096905355 -1.86615184591657 -1 14.2828737025226 1420 2049 2320 2241 970 1352 1174 3750 1268 2372 1241 1047 M15722 GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. 200/298 Gene Ontology BP GO:0090257 4.24803816827944e-08 4.02645553947883e-07 1795 1401.27272727273 1422 3.86185295482357e-09 162 2.398120586713 2.43665253290925 1 18.4445606321005 1792 1663 265 877 162 1422 4153 1476 1402 385 1817 1048 M13795 GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 12/15 Gene Ontology BP GO:0030207 5.61073179331423e-06 6.90654365986537e-06 590 1766.90909090909 1423 5.10067827508882e-07 589 2.52415828788602 2.96799155056233 1 15.6512841546318 589 1174 1680 3160 3753 880 1136 1022 2534 2085 1423 1049 M14711 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization. 21/22 Gene Ontology BP GO:0031116 2.05439975863724e-07 5.00119458251237e-07 1425 1887.09090909091 1423 1.86763631861894e-08 222 1.2882062213556 1.36977501223445 1 9.71359028626321 1354 2140 3381 3504 1833 890 831 1423 1423 3757 222 1050 M15092 GO_PROSTATE_GLAND_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_GROWTH.html The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. 14/17 Gene Ontology BP GO:0060736 1.6573186963757e-07 4.52287618430271e-07 1400 1390.54545454545 1424 1.50665347384177e-08 360 2.10146400327432 -1.95613030763022 -1 16.0218373390964 1399 1107 1991 1424 1618 1797 1150 696 360 2047 1707 1051 M15944 GO_ARACHIDONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. 37/110 Gene Ontology BP GO:0019369 1.66931265835948e-07 4.53963284590687e-07 895 1291.72727272727 1425 1.51755707729395e-08 363 2.44788702699614 -2.16405110063172 -1 18.6752297615676 891 1980 1266 1502 1626 609 497 1647 2403 1425 363 1052 M16514 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 39/77 Gene Ontology BP GO:1903556 6.81487881968048e-07 1.10902498801874e-06 1125 1485.45454545455 1425 6.19534630064314e-08 491 2.28752916887577 -2.90319537114183 -1 16.3719007624098 1125 1969 1425 1768 2814 1195 670 894 1519 2470 491 1053 M15077 GO_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_RECOGNITION.html The process in which a cell in an organism interprets its surroundings. 128/345 Gene Ontology BP GO:0008037 1.8209497282518e-10 4.3674634461627e-09 1655 1275.63636363636 1426 1.65540884400229e-11 133 2.73886503543407 2.96148347237503 1 27.5877468892856 1652 1801 133 678 2285 877 2115 1426 1234 236 1595 1054 M13211 GO_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 91/128 Gene Ontology BP GO:0060191 2.12647829915671e-07 5.1104354191636e-07 2655 1525.63636363636 1429 1.93316227699827e-08 132 2.51126335540475 -2.77239531983628 -1 19.0051805014998 2654 132 346 204 1864 3331 3370 741 2401 310 1429 1055 M10129 GO_SYNAPTIC_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_LOCALIZATION.html Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. 110/155 Gene Ontology BP GO:0097479 2.20779436849453e-07 5.1743738716224e-07 1435 1525.54545454545 1431 2.00708599096018e-08 61 1.86377123985669 -1.6050632320645 -1 14.066258050589 1431 61 1683 1062 1917 462 927 4342 749 1986 2161 1056 M11382 GO_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins. 41/47 Gene Ontology BP GO:0097435 4.6300410271784e-05 5.091841384888e-05 135 1993.09090909091 1432 4.20921679293722e-06 135 2.67958771914186 2.63921975270433 1 13.8097138557846 135 2517 628 1432 4203 1137 2232 2955 4154 1347 1184 1057 M10827 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. 77/123 Gene Ontology BP GO:1903428 5.7227526672478e-07 9.80772307944899e-07 1195 1614.36363636364 1433 5.20250377807279e-08 272 2.27482798113916 -2.52400905826857 -1 16.4272650210527 1195 2445 1433 272 2672 2081 2408 604 1085 2207 1356 1058 M13385 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of activation. 272/554 Gene Ontology BP GO:0050867 8.45088656786874e-08 4.02645553947883e-07 1360 1556.72727272727 1433 7.68262444772151e-09 429 1.94265905491461 -1.83808037168145 -1 14.9219349548839 1360 1586 865 1545 798 1096 1433 2481 3797 429 1734 1059 M15197 GO_GLYCEROLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. 28/46 Gene Ontology BP GO:0046503 2.63664643488191e-07 5.72483241320837e-07 1435 1687.72727272727 1434 2.39695159170692e-08 529 2.19779344352215 -2.25684801020207 -1 16.4889433750724 1434 834 1789 3381 2083 1362 637 1153 3644 1719 529 1060 M11002 GO_SINGLE_ORGANISM_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELL_ADHESION.html The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. 478/734 Gene Ontology BP GO:0098602 9.62484966988559e-26 2.63437797141045e-23 2750 1549.90909090909 1435 8.74986333625959e-27 8 2.38701072184941 2.73803110363203 1 65.0800317295198 2749 1435 8 289 232 2274 4228 2299 1358 43 2134 1061 M10799 GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. 60/65 Gene Ontology BP GO:1901185 1.41705745388838e-07 4.2854237685504e-07 1035 1940.36363636364 1436 1.2882341319668e-08 841 1.44770095911809 -1.35659813008579 -1 11.0464384681794 1033 2862 3566 2142 1436 946 841 1449 1375 4264 1430 1062 M14290 GO_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. 44/63 Gene Ontology BP GO:0006939 2.61934920662178e-07 5.71126141443822e-07 4575 1875.18181818182 1436 2.38122683498639e-08 271 3.07875131862158 3.89542602515971 1 23.1434362844805 4571 487 271 462 2073 4099 3218 1436 777 618 2615 1063 M15914 GO_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. 492/738 Gene Ontology BP GO:0030855 1.18656432648601e-24 2.30045158797476e-22 4105 2029.63636363636 1436 1.07869484226001e-25 4 2.45763404999893 2.7208239460605 1 64.2112749478458 4104 1436 10 4 165 3057 4008 4117 799 57 4569 1064 M14484 GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 254/307 Gene Ontology BP GO:0051494 1.75165594537726e-07 4.65466347597117e-07 970 1288.09090909091 1438 1.59241462258672e-08 476 1.78123905905837 1.94692145317605 1 13.5378405156436 969 1587 1618 1484 1670 476 1102 1438 1410 1445 970 1065 M10486 GO_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical. 783/1214 Gene Ontology BP GO:0048878 7.06189899882018e-11 1.8460121371635e-09 2070 1554.54545454545 1439 7.06189899904461e-12 101 2.18555528978094 -1.99964843013433 -1 22.9821725907436 2067 1381 4245 1235 275 958 1653 1792 1954 101 1439 1066 M13363 GO_POSITIVE_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HAIR_CYCLE.html Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 10/13 Gene Ontology BP GO:0042635 9.50945580896861e-07 1.43534740556727e-06 2590 1555.72727272727 1440 8.6449635631039e-08 25 4.51349424361507 5.15741813490919 1 31.7919229668018 2588 1192 613 401 3046 2068 2604 1440 25 1153 1983 1067 M10937 GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that activates or increases the activity of a transporter. 89/118 Gene Ontology BP GO:0032411 1.91287250844156e-07 4.88775166489764e-07 950 1227 1442 1.73897515887587e-08 474 2.62935307625302 2.87952365622653 1 19.9652499427775 950 1843 474 1720 1740 479 1442 1773 1627 894 555 1068 M16620 GO_ALCOHOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 63/86 Gene Ontology BP GO:0046164 1.54635589162411e-07 4.40634342739212e-07 1885 1477.81818181818 1442 1.40577818210525e-08 738 2.22103917801905 -2.37146231387177 -1 16.9698033542082 1016 1885 1442 1925 1539 738 1053 1039 2506 1883 1230 1069 M13461 GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of dendrite development. 91/107 Gene Ontology BP GO:1900006 3.66613709146326e-07 7.1348082959502e-07 190 1242 1444 3.33285245672546e-08 128 1.97282465768136 2.22012891061429 1 14.5624349712385 187 2835 1864 1638 2335 128 420 711 1444 1930 170 1070 M15097 GO_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of ions within an organism or cell. 500/819 Gene Ontology BP GO:0050801 2.22996113484453e-13 8.30080732834526e-12 2405 1370.81818181818 1444 2.02723739531342e-14 77 2.22535630494117 -2.0545600118838 -1 29.7194568854433 2405 1444 77 1238 326 1186 1935 2017 2174 97 2180 1071 M16757 GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 68/105 Gene Ontology BP GO:0002088 9.9563417275034e-08 4.02645553947883e-07 3420 1815.90909090909 1445 9.05122016189872e-09 279 1.75182429812621 2.17763378385861 1 13.4459828328377 3420 279 1970 820 995 4334 3249 1445 1258 1891 314 1072 M14090 GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. 11/18 Gene Ontology BP GO:0070296 2.56076163062735e-07 5.66043889183328e-07 1450 1417.63636363636 1446 2.32796538972326e-08 228 1.95272999718229 2.14961736750498 1 14.6504767412244 1446 2250 1982 2021 2045 988 1571 228 682 1357 1024 1073 M12279 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE.html Any process that modulates the size of an anatomical structure. 492/671 Gene Ontology BP GO:0090066 7.83235358015018e-16 4.39083629017334e-14 2425 1565 1447 7.12032143650014e-17 46 2.27523670028422 2.58799907409909 1 36.6522803453983 2425 1447 46 333 224 2352 4327 2119 1361 133 2448 1074 M11448 GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. 45/68 Gene Ontology BP GO:0003254 1.32751458750452e-07 4.20399283289481e-07 2115 1726.63636363636 1448 1.20683151600804e-08 494 2.62654229215406 2.8673974459331 1 20.151692083494 2113 494 617 1324 1363 2022 2850 1448 2526 1128 3108 1075 M16847 GO_INNER_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. 123/188 Gene Ontology BP GO:0042472 2.58741343464638e-07 5.67775356325191e-07 1840 1520.18181818182 1449 2.35219430813759e-08 7 2.34946175978472 2.54653474128671 1 17.6441298939933 1839 7 332 566 2059 1967 4581 2339 1449 546 1037 1076 M12435 GO_MITOTIC_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis. 49/58 Gene Ontology BP GO:0090307 4.55885401050392e-07 8.3153068251175e-07 1380 1436.54545454545 1451 4.14441359562984e-08 442 1.89512793482227 2.19137800275446 1 13.8324543192479 1380 442 2110 2370 2500 1451 1507 564 837 1962 679 1077 M11237 GO_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_TRANSPORT.html The directed movement of substances into, out of or within a vacuole. 290/316 Gene Ontology BP GO:0007034 1.42939559183113e-07 4.2854237685504e-07 105 2101.72727272727 1452 1.29945062245689e-08 7 1.16360971546149 -1.177647505421 -1 8.85852401547818 104 3633 4171 4389 1452 7 189 1028 3460 4472 214 1078 M13120 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS.html Any microtubule cytoskeleton organization that is involved in mitosis. 49/58 Gene Ontology BP GO:1902850 4.55885401050392e-07 8.3153068251175e-07 1385 1423.90909090909 1452 4.14441359562984e-08 415 1.89512793482227 2.19137800275446 1 13.8324543192479 1381 443 2111 2371 2501 1452 1508 415 838 1963 680 1079 M10174 GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST.html Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. 8/28 Gene Ontology BP GO:0044144 6.97189062100998e-08 4.02645553947883e-07 685 1516.81818181818 1453 6.97189083974264e-09 233 2.25975934913978 -2.38606137509256 -1 17.3744486376091 685 2290 4230 1808 676 887 233 1453 1995 1576 852 1080 M15995 GO_MESENCHYME_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_MORPHOGENESIS.html The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. 47/58 Gene Ontology BP GO:0072132 2.82493703246447e-07 5.98835171392127e-07 4615 1686.18181818182 1454 2.56812490473095e-08 302 2.82323945657248 -1.96822373054393 -1 21.1439179984605 4611 446 302 508 2136 3501 2283 1526 980 801 1454 1081 M10533 GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 41/84 Gene Ontology BP GO:0090207 1.43240839802291e-07 4.28892939253578e-07 690 1541.27272727273 1456 1.30218953753298e-08 548 1.86231088288178 -1.97956166601928 -1 14.2387361508654 689 2518 2431 2249 1456 548 608 2337 1110 2404 604 1082 M12885 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. 55/92 Gene Ontology BP GO:1903727 2.82659188985698e-07 5.98913117645926e-07 3125 1777.63636363636 1456 2.56962932092879e-08 391 2.171506505999 -2.04039766835389 -1 16.2390176628044 3122 391 1103 826 2137 2521 1327 3073 1456 1026 2572 1083 M11627 GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. 29/44 Gene Ontology BP GO:0045746 1.26598060232596e-07 4.16747130248656e-07 2115 1255.90909090909 1458 1.15089152288752e-08 424 2.92800419294681 -2.4998591675999 -1 22.4898419920724 2112 723 457 1475 1304 1529 1144 1613 1458 424 1576 1084 M14237 GO_REGULATION_OF_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. 459/729 Gene Ontology BP GO:0044057 6.12514074484966e-26 2.03573427755611e-23 3025 1294.09090909091 1458 5.56830976804513e-27 6 2.54225685189918 2.73572829231631 1 69.6636183746337 1479 1458 6 831 369 753 3022 3024 1636 49 1608 1085 M14470 GO_LYMPH_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. 15/17 Gene Ontology BP GO:0036303 9.95265633695553e-06 1.17477701511553e-05 3475 1915.27272727273 1459 9.04791032946186e-07 294 2.59954042772496 2.83377288678739 1 15.3964972984337 3475 1069 1459 752 3915 3318 3792 677 532 1785 294 1086 M14622 GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of guanylate cyclase activity. 7/14 Gene Ontology BP GO:0031282 4.5986295925313e-07 8.37472543798361e-07 1440 1928.27272727273 1459 4.5986305441643e-08 98 2.3737602365434 -2.46287913746543 -1 17.3430956785235 1437 1278 4505 1122 2592 1847 1003 98 3957 1913 1459 1087 M11915 GO_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. 60/112 Gene Ontology BP GO:0031016 9.43591375360045e-08 4.02645553947883e-07 1460 1346.63636363636 1460 8.57810378028338e-09 166 1.97838169105854 -2.1926867346454 -1 15.1982205828744 1814 329 1456 166 934 1894 1694 1824 1460 1806 1436 1088 M16936 GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 37/58 Gene Ontology BP GO:0002067 2.497488663166e-07 5.59830093920551e-07 1890 1252.27272727273 1461 2.27044449698771e-08 61 2.53561268747992 -2.34626764194549 -1 19.0690231414597 1890 573 1128 171 2014 2265 1809 1461 61 1689 714 1089 M11532 GO_REGULATION_OF_WATER_LOSS_VIA_SKIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WATER_LOSS_VIA_SKIN.html A process that modulates the rate or extent of water loss from an organism via the skin. 28/34 Gene Ontology BP GO:0033561 2.17871385024075e-09 4.25947711981941e-08 4190 1911 1462 1.9806489567258e-10 50 3.84490623260309 -2.99778369697251 -1 34.1706782823868 4186 667 168 302 1844 3637 3826 4595 50 284 1462 1090 M14503 GO_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 487/735 Gene Ontology BP GO:0042493 2.81798916701941e-11 8.04423533382902e-10 2140 1458.45454545455 1462 2.56180833368681e-12 112 2.28407392937847 2.51791663590906 1 25.01930308414 2139 1462 112 492 637 1592 4320 1251 2172 369 1497 1091 M15275 GO_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_MOVEMENT.html A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules. 217/278 Gene Ontology BP GO:0007018 7.40190985459036e-08 4.02645553947883e-07 775 1930.45454545455 1463 6.72900918511634e-09 125 1.74656151670043 1.98604516582913 1 13.4052794853764 772 3424 3131 4307 630 125 835 1463 2303 3727 518 1092 M15643 GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. 28/31 Gene Ontology BP GO:0046827 4.49141924314366e-07 8.24401330901281e-07 530 1758.27272727273 1463 4.08310923644682e-08 310 2.05248783007888 2.17645485084878 1 14.9988488654952 529 3257 2742 1877 2485 1037 715 1372 310 3554 1463 1093 M14537 GO_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. 191/208 Gene Ontology BP GO:0007033 1.61257220720623e-07 4.4655132638076e-07 90 1612.63636363636 1464 1.46597484127795e-08 6 1.3419548120227 -1.22891286471298 -1 10.2030252401391 89 1708 4014 3890 1591 6 116 471 1464 4311 79 1094 M12647 GO_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BACTERIUM.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. 455/948 Gene Ontology BP GO:0009617 3.48654511767847e-09 6.33706813771794e-08 910 1521.18181818182 1465 3.16958647563993e-10 182 2.17819791175228 -2.24193537982989 -1 18.8590763442221 910 1475 182 2834 1193 1419 1784 1465 3309 215 1947 1095 M15186 GO_ENDOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_SYSTEM_DEVELOPMENT.html Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. 85/165 Gene Ontology BP GO:0035270 6.53786121869069e-08 4.02645553947883e-07 2710 1846.18181818182 1465 5.94351037543629e-09 178 2.16717468943955 2.33889658195248 1 16.6583813590211 2708 178 1194 209 490 2121 2863 4496 1451 1465 3133 1096 M13361 GO_CELLULAR_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. 142/197 Gene Ontology BP GO:0044242 1.00189858595071e-07 4.02645553947883e-07 680 1842.36363636364 1466 9.10816937798204e-09 678 1.80068945942726 -1.71332165391026 -1 13.8239152374488 678 2816 2956 2423 1005 1243 1413 699 3093 2474 1466 1097 M13213 GO_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE.html Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. 489/1073 Gene Ontology BP GO:0045087 1.60074210111572e-07 4.46003173442602e-07 265 1436.09090909091 1467 1.45522019780667e-08 261 2.13453363446086 -2.20499569556841 -1 16.2912718656832 550 1467 261 2643 1780 1050 1059 2030 3096 261 1600 1098 M10879 GO_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SECRETION.html The controlled release of proteins from a cell. 114/190 Gene Ontology BP GO:0009306 7.65854370416714e-08 4.02645553947883e-07 1725 1469.09090909091 1468 6.96231270070276e-09 59 1.88672342646076 -1.87102499339513 -1 14.4893182193172 1723 59 1468 1579 674 1248 1256 1581 3607 1435 1530 1099 M10835 GO_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_LOCALIZATION.html Any process in which is the spindle is transported to, and/or maintained in, a specific location. 49/67 Gene Ontology BP GO:0051653 2.19904159922316e-07 5.16774775817444e-07 925 1485.45454545455 1469 1.99912892639233e-08 430 1.94561846448368 2.29341876592785 1 14.6898064188125 925 491 2222 2860 1912 793 1469 430 1793 2958 487 1100 M14884 GO_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ASSEMBLY.html A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. 179/211 Gene Ontology BP GO:0034329 9.95126264011313e-13 3.4814454935674e-11 1515 1377.54545454545 1470 9.04660240010691e-14 83 2.73116183421699 2.96142904750771 1 34.4412363027711 1514 1681 83 282 967 1470 2843 3286 218 312 2497 1101 M15836 GO_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that modulates the frequency, rate or extent of viral genome replication. 95/138 Gene Ontology BP GO:0045069 4.33530420676793e-07 8.05276266430785e-07 140 1441.72727272727 1470 3.94118641916373e-08 138 2.1117301589415 -2.38544878270998 -1 15.4607765300133 138 2833 1581 1514 2456 1305 965 262 2059 1470 1276 1102 M10283 GO_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. 323/410 Gene Ontology BP GO:0006644 1.46902397680952e-07 4.35651278782326e-07 750 1458.63636363636 1471 1.33547643172897e-08 192 1.75436216980025 -1.7518210196507 -1 13.393014227912 748 1554 2673 2373 1471 192 957 1001 2001 2662 413 1103 M13940 GO_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell. 445/577 Gene Ontology BP GO:0040007 1.80791767512254e-09 3.57967699674264e-08 2390 1551.72727272727 1471 1.64356152418933e-10 165 2.18911687613512 2.50379817173604 1 19.6108309641565 2389 1471 165 412 343 1995 3966 2956 1409 214 1749 1104 M15557 GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. 23/31 Gene Ontology BP GO:2001026 1.12572039787052e-06 1.63840381960948e-06 1110 1946.27272727273 1472 1.02338270353821e-07 1071 1.96969407701115 2.03112025896754 1 13.6791175664383 1109 2076 1472 1217 3166 1103 1439 3014 3569 1071 2173 1105 M10497 GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH.html The activation of endogenous cellular processes that result in the death of a cell as part of its development. 31/41 Gene Ontology BP GO:0010623 1.27654895786044e-06 1.821460380535e-06 1480 1627.54545454545 1473 1.16049972597997e-07 527 2.54469697477438 2.52834881145075 1 17.5608860719071 1477 2924 1524 1443 3226 775 1139 1473 527 2120 1275 1106 M13846 GO_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T cell differentiation. 100/190 Gene Ontology BP GO:0045580 4.29940996619103e-07 8.01488564610852e-07 735 1768.72727272727 1474 3.90855527855925e-08 119 1.70700185913182 -1.62828975987563 -1 12.4821018011681 731 119 2522 3027 2447 822 1474 2201 3604 1222 1287 1107 M10171 GO_OLIGOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 56/71 Gene Ontology BP GO:0009311 5.50586291383239e-08 4.02645553947883e-07 2490 1539.63636363636 1475 5.00533004693243e-09 329 2.16557659063961 -1.94140757746099 -1 16.6460213604825 2490 364 1475 1262 329 2543 1285 1953 410 1675 3150 1108 M13740 GO_NEGATIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 188/307 Gene Ontology BP GO:0051048 9.17866727992732e-08 4.02645553947883e-07 1980 1308.45454545455 1475 8.34424332988406e-09 62 2.34097030755808 -2.30973696303047 -1 18.0025495581547 1978 1689 279 62 906 1475 1758 2610 1141 494 2001 1109 M15684 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. 14/30 Gene Ontology BP GO:0060850 8.87149820017436e-07 1.3605498063748e-06 1475 1471.81818181818 1475 8.06500161600664e-08 159 2.00318121225758 -2.45471536669964 -1 14.1089521683925 1475 2686 2586 1590 2994 1295 159 382 236 2496 291 1110 M10757 GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of an adaptive immune response. 115/220 Gene Ontology BP GO:0002819 3.9546721724819e-07 7.51678497490126e-07 485 1727.45454545455 1476 3.59515716669578e-08 483 1.77031812777015 -1.75461967640422 -1 13.0085678826597 483 1824 2191 3446 2398 897 1069 638 3618 1476 962 1111 M12172 GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. 71/92 Gene Ontology BP GO:0001954 1.6445091574211e-07 4.51606749661201e-07 1480 1465.45454545455 1476 1.49500843668078e-08 243 2.20717264887099 2.59711447339777 1 16.8346994353235 1476 243 547 646 1606 1588 3620 2558 2336 521 979 1112 M12691 GO_SPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 125/149 Gene Ontology BP GO:0006665 7.03157874987592e-08 4.02645553947883e-07 1875 1491.63636363636 1477 6.39234452237937e-09 18 1.79790496191175 -1.85603218585011 -1 13.8023794067332 1872 18 2463 3129 575 1198 1586 1186 1274 1477 1630 1113 M12201 GO_TAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAXIS.html The directed movement of a motile cell or organism in response to an external stimulus. 410/733 Gene Ontology BP GO:0042330 2.82187816835303e-27 1.31301991173466e-24 1760 1318.18181818182 1478 2.56534378941184e-28 2 2.54275750654816 2.65197401335409 1 73.3382338449963 1756 1478 2 315 378 1080 3454 1802 2115 28 2092 1114 M16423 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 16/33 Gene Ontology BP GO:0090208 6.47685777437913e-07 1.07363089505472e-06 1075 2026 1478 5.88805425562168e-08 398 1.68981963748692 -1.81315125873675 -1 12.0959652350028 1072 3804 3302 2746 2763 650 1060 1422 1478 3591 398 1115 M10248 GO_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION.html The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 411/1652 Gene Ontology BP GO:0007600 2.46357405866954e-24 4.40885003653437e-22 2755 1610 1479 2.23961278060867e-25 6 2.5315242468846 2.70808680126914 1 65.2799750344034 2752 1479 12 6 639 2321 4632 1925 1301 65 2578 1116 M10107 GO_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 432/813 Gene Ontology BP GO:0050865 7.58733726932258e-09 1.30272621085454e-07 1480 1475.81818181818 1480 6.89757935953611e-10 151 2.0504599119788 -1.94522690639748 -1 16.9709723435251 1480 1486 263 1082 622 1357 1613 2474 3516 151 2190 1117 M10671 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. 62/82 Gene Ontology BP GO:0051148 1.48350211737641e-07 4.36901586057683e-07 4255 2461.81818181818 1480 1.34863837946528e-08 328 2.3170042743379 2.32876900478508 1 17.7178244623302 4253 328 1030 961 1480 4443 3987 4427 829 1045 4297 1118 M12535 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. 47/88 Gene Ontology BP GO:0032735 1.05960619192363e-06 1.56023658576603e-06 200 1899.54545454545 1481 9.6327882024712e-08 200 1.40552928439453 -1.501874245489 -1 9.76770896468799 200 2483 2744 2996 3123 620 818 1075 4053 1481 1302 1119 M12865 GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 228/317 Gene Ontology BP GO:0090092 1.10055693423907e-07 4.02645553947883e-07 2450 1780.81818181818 1481 1.00050635390435e-08 353 2.27657536534727 2.45707678798405 1 17.5045068891745 2450 2361 353 1273 1147 1189 3778 2599 2427 531 1481 1120 M11082 GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC.html The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine. 10/32 Gene Ontology BP GO:0007271 1.24280661400515e-05 1.44786659363193e-05 1530 1508.45454545455 1482 1.12983057711416e-06 74 3.22147902703237 -2.74013773352847 -1 18.7510768992035 1526 2271 1482 1480 4090 1438 74 274 285 2144 1529 1121 M15931 GO_MELANOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. 25/30 Gene Ontology BP GO:0030318 3.94266538245293e-07 7.51011780073326e-07 2320 1445.36363636364 1482 3.58424189911483e-08 130 2.59534927828987 -2.36590154988561 -1 19.1202143564635 2316 764 794 130 2392 2951 1540 1482 923 664 1943 1122 M16234 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 449/537 Gene Ontology BP GO:0010639 2.67564873856688e-07 5.77246137399951e-07 870 1666.81818181818 1482 2.43240823998219e-08 414 1.65821724495043 1.82253151347486 1 12.4082803389852 870 1482 3293 2028 2096 414 830 915 2257 3280 870 1123 M14618 GO_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 25/33 Gene Ontology BP GO:0072215 1.36124137860264e-07 4.23928240920297e-07 2035 1819.63636363636 1483 1.23749223893539e-08 552 2.53907965201997 2.35851965528154 1 19.4660736183669 2033 859 1283 552 1392 1257 2335 4647 2202 1973 1483 1124 M10430 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. 24/45 Gene Ontology BP GO:0045956 1.60545408794982e-07 4.46513919380185e-07 2110 1677.27272727273 1484 1.45950382282558e-08 866 2.42791268103582 -2.00641651962191 -1 18.5431024454065 2108 866 1399 1099 1587 1959 1484 973 3129 1460 2386 1125 M14280 GO_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_CHEMOTAXIS.html The directed movement of a lymphocyte in response to an external stimulus. 20/56 Gene Ontology BP GO:0048247 3.28688964602657e-06 4.2248335698789e-06 1485 1906.90909090909 1484 2.98808596071264e-07 350 2.80463578643565 -3.10806491620032 -1 18.1258610619614 601 2636 1484 3916 3596 535 486 350 3971 1919 1482 1126 M11183 GO_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE.html Any process that modulates the frequency, rate or extent of a defense response. 740/1123 Gene Ontology BP GO:0031347 1.84162882314985e-07 4.7749337740829e-07 995 1892 1485 1.84162897577171e-08 778 2.03172510433749 -1.94490313550895 -1 15.4288493705201 994 2325 4284 1485 1815 1342 1162 2116 3107 778 1404 1127 M12614 GO_SULFUR_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 35/44 Gene Ontology BP GO:0044273 8.28298251168116e-08 4.02645553947883e-07 1145 1692.63636363636 1485 7.52998438503165e-09 619 1.99867532715334 2.50290827148247 1 15.3551754047435 1141 619 1485 3144 780 1428 2103 1671 3199 1446 1603 1128 M13511 GO_NEURONAL_ION_CHANNEL_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ION_CHANNEL_CLUSTERING.html The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. 16/29 Gene Ontology BP GO:0045161 5.3450841151088e-07 9.31137266477022e-07 2155 1700.27272727273 1487 4.85916855794741e-08 90 3.21671484433029 3.20313960716794 1 23.3593060452342 2153 997 905 90 2624 1487 1009 4613 247 1543 3035 1129 M12316 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. 127/212 Gene Ontology BP GO:1902107 1.99570067673324e-07 4.94198789187854e-07 745 1592.90909090909 1488 1.81427350706417e-08 660 1.91746239743962 -2.04451558811099 -1 14.5207197922537 742 1816 1488 2435 1801 1081 1676 891 3725 660 1207 1130 M12332 GO_CARDIAC_ATRIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_ATRIUM_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. 31/55 Gene Ontology BP GO:0003230 5.66878314981524e-08 4.02645553947883e-07 4625 2303.72727272727 1488 5.15343935989445e-09 351 2.39194831627572 -2.18288824694477 -1 18.3968231245151 4624 2019 1444 1170 351 4644 3355 1198 467 1488 4581 1131 M16783 GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 113/155 Gene Ontology BP GO:0010717 2.08194209377652e-07 5.03496702824436e-07 1710 1608.36363636364 1488 1.89267480981682e-08 52 2.08192065812074 2.27021231597353 1 15.7545915996752 1708 52 837 627 1849 1488 3937 3526 1298 821 1549 1132 M13580 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. 122/186 Gene Ontology BP GO:2000379 1.23363314543556e-07 4.14338946095474e-07 2640 1765.27272727273 1489 1.12148474055508e-08 54 2.23822527716808 -2.30026909903007 -1 17.1742455246455 2636 54 847 1023 1270 3580 3314 1429 2139 1637 1489 1133 M11973 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. 118/218 Gene Ontology BP GO:0070665 2.57029592513585e-07 5.67073823596828e-07 1230 1617.09090909091 1491 2.33663293220706e-08 39 1.94722262221329 -1.77369655216375 -1 14.6070077136057 1230 39 1006 1998 2049 1048 1491 3070 3617 381 1859 1134 M13112 GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). 45/111 Gene Ontology BP GO:0007200 7.33326098042566e-07 1.17176041696156e-06 1990 1343.36363636364 1492 6.66660311347547e-08 360 3.03890200473355 -2.74882745030553 -1 21.695483047402 1989 513 407 1492 2869 1572 938 360 1710 565 2362 1135 M15575 GO_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. 59/74 Gene Ontology BP GO:0060350 1.8262235891195e-06 2.4875346487626e-06 575 1882.36363636364 1492 1.66020464097495e-07 572 2.31396794384201 2.45810143059606 1 15.5805197069238 572 1892 966 1412 3388 1123 2336 3367 2892 1492 1266 1136 M10719 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. 11/15 Gene Ontology BP GO:0002583 5.44105721534339e-08 4.02645553947883e-07 4175 1911.18181818182 1494 4.9464157726473e-09 320 2.43020917310781 2.23267912924743 1 18.6927398316339 4171 1163 1339 1494 320 3290 2782 2953 635 1353 1523 1137 M11868 GO_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH.html Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. 683/998 Gene Ontology BP GO:0040008 5.03618619955395e-08 4.02645553947883e-07 1870 1597.45454545455 1494 5.03618631368822e-09 51 2.09437726493607 2.28450811641774 1 16.0953523019267 1866 1398 4328 51 336 1494 3000 1936 1377 285 1501 1138 M13377 GO_GRANULOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_ACTIVATION.html The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 21/32 Gene Ontology BP GO:0036230 3.4318077397033e-07 6.8533053273989e-07 535 1844.18181818182 1494 3.11982570457766e-08 531 1.68490748924947 -1.43343356402717 -1 12.45776815543 531 986 2589 3272 2274 1086 651 966 2993 3444 1494 1139 M14330 GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of T cell mediated immunity. 53/118 Gene Ontology BP GO:0002709 1.45174849363311e-06 2.03340931392983e-06 440 1791.81818181818 1494 1.31977222874731e-07 396 1.49366781696723 -1.54721882429486 -1 10.1788805550573 440 396 2685 2936 3290 678 1065 1494 3987 1643 1096 1140 M12121 GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 31/43 Gene Ontology BP GO:0010743 7.44503307100162e-07 1.18392819136605e-06 670 1791.90909090909 1496 6.76821417316444e-08 667 2.37065982282733 -2.19984825372659 -1 16.8892314095394 667 2030 1474 2908 2882 1463 1332 1496 3026 848 1585 1141 M11859 GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 28/35 Gene Ontology BP GO:0090200 1.87668665218071e-06 2.55029877120235e-06 1250 1941.63636363636 1497 1.70608023006387e-07 261 2.43280038563519 2.3628976442282 1 16.354094824523 1250 3524 2275 3248 3393 312 261 1497 422 3957 1219 1142 M12209 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 20/30 Gene Ontology BP GO:0010523 4.5157123029763e-07 8.26903161973583e-07 675 1850.90909090909 1497 4.10519384533645e-08 660 1.7005371941129 1.69016871586556 1 12.4065580147345 673 946 2362 3246 2492 660 745 2359 4146 1497 1234 1143 M14373 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 195/240 Gene Ontology BP GO:0043242 1.49811040255445e-07 4.36901586057683e-07 1140 1447.90909090909 1497 1.36191864051788e-08 827 1.78967433761267 1.969930283716 1 13.6619700616747 1140 1660 1847 1899 1497 827 1330 1901 1117 1549 1160 1144 M14531 GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. 14/25 Gene Ontology BP GO:0035590 1.61518564861126e-07 4.4655132638076e-07 890 1546 1497 1.46835069744928e-08 812 3.34212867934655 -2.66346060173428 -1 25.5640178517055 2476 1078 812 886 1597 2083 1497 1727 894 886 3070 1145 M10795 GO_MALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. 13/30 Gene Ontology BP GO:0030539 1.04237022949624e-05 1.22602342716026e-05 820 1648.36363636364 1498 9.47613789388741e-07 578 2.28567365892557 2.16675123589407 1 13.4738443863924 819 2236 1932 1498 3929 1232 1522 659 954 2773 578 1146 M12064 GO_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION.html The controlled release of a substance by a cell or a tissue. 575/906 Gene Ontology BP GO:0046903 6.24818538252084e-08 4.02645553947883e-07 2030 1731.54545454545 1498 6.24818555820004e-09 279 2.16968532546989 -2.11147258509687 -1 16.6777990931856 2029 1419 4342 1041 543 1498 1447 2143 2446 279 1860 1147 M14182 GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in an epithelial cell. 47/55 Gene Ontology BP GO:1904019 8.60638173325605e-07 1.32953168010758e-06 910 1747.27272727273 1499 7.82398645460663e-08 481 3.00342494940715 3.08049957540096 1 21.2417321288791 907 1922 481 616 2971 1499 2962 3193 1246 1107 2316 1148 M13328 GO_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_NUCLEAR_DIVISION.html A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. 419/475 Gene Ontology BP GO:0007067 2.20714273699494e-07 5.1743738716224e-07 185 1519 1500 2.00649359856894e-08 182 1.62422094797238 1.84384314189193 1 12.245090452322 182 1500 3508 2836 1916 491 498 976 1686 2063 1053 1149 M15201 GO_MATURE_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION.html The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. 21/24 Gene Ontology BP GO:0002335 1.49859215849573e-07 4.36901586057683e-07 3610 1819.90909090909 1501 1.36235660052416e-08 181 2.42011883747267 -2.10956141569618 -1 18.5109098260381 3606 889 1107 181 1501 3398 1775 4495 487 835 1745 1150 M16358 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE.html Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. 24/40 Gene Ontology BP GO:0043576 1.78905383922956e-06 2.4477039903444e-06 345 1435.81818181818 1501 1.62641390372823e-07 292 2.02329164041132 1.85712593226461 1 13.6275445522333 341 2582 1812 1741 3369 428 605 958 1501 2165 292 1151 M16719 GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 46/72 Gene Ontology BP GO:0060119 2.68217690897606e-08 3.59659053529268e-07 3255 1913.45454545455 1501 2.43834267425126e-09 43 2.09567287412106 2.36587992232814 1 16.2296442256517 3253 483 1501 1371 43 3767 3943 3151 1143 2162 231 1152 M10707 GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 9. 31/53 Gene Ontology BP GO:0034162 1.34992967973998e-06 1.91151028601039e-06 1300 1709.72727272727 1503 1.22720955278499e-07 383 2.67710007596673 -2.63389300052718 -1 18.4121016230602 1300 3245 1691 786 3255 1908 1200 470 383 3066 1503 1153 M15523 GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. 396/638 Gene Ontology BP GO:0002683 8.8638777989913e-08 4.02645553947883e-07 1505 1408.18181818182 1503 8.05807105101826e-09 248 2.07669290128293 -2.10299775664543 -1 15.958578086893 1341 1503 278 1078 863 1756 1934 1504 3054 248 1931 1154 M12775 GO_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 105/118 Gene Ontology BP GO:0038127 1.29729347182033e-07 4.18739690741189e-07 740 1513.27272727273 1504 1.17935777119908e-08 114 1.87935142229545 -1.89502657309176 -1 14.3936145089532 738 114 2448 1011 1334 1543 1504 1377 1709 3298 1570 1155 M13473 GO_FACE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FACE_DEVELOPMENT.html The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. 76/90 Gene Ontology BP GO:0060324 9.32189853145815e-07 1.41701384733338e-06 155 1659.63636363636 1504 8.47445680123648e-08 151 2.22257484898681 2.43702415755712 1 15.6180089399122 151 2844 1016 1869 3025 251 991 3143 3091 1504 371 1156 M11112 GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE.html A process that modulates the size of a cellular component. 383/480 Gene Ontology BP GO:0032535 4.54225151827372e-08 4.02645553947883e-07 3180 1870.09090909091 1505 4.12931964732343e-09 186 2.17468797225989 2.45210537702687 1 16.7164905101465 3179 1505 258 388 186 3205 4647 2522 918 483 3280 1157 M14364 GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 13/13 Gene Ontology BP GO:0009263 7.05302074382964e-07 1.13634714408031e-06 770 1552.09090909091 1505 6.41183909542877e-08 211 1.89530549728135 1.93147233626835 1 13.5228656670465 769 1101 2245 1505 2844 1208 1225 1657 211 1816 2492 1158 M15198 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin polymerization. 76/97 Gene Ontology BP GO:0030838 8.50726796544623e-08 4.02645553947883e-07 1680 1271.09090909091 1505 7.733880267652e-09 231 2.07888683782732 -1.86772258302621 -1 15.9755464073018 1678 231 1536 570 808 1578 1013 2149 687 1505 2227 1159 M16025 GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. 32/37 Gene Ontology BP GO:0044803 1.50505037876544e-07 4.37329540718478e-07 100 1923.09090909091 1505 1.36822771066184e-08 61 1.0971639573338 -1.06016391177346 -1 8.33509860477164 98 3505 3743 4174 1505 126 61 89 3805 3825 223 1160 M11502 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 38/54 Gene Ontology BP GO:0090313 4.51335154372082e-07 8.26903161973583e-07 1510 1936.18181818182 1506 4.10304769967793e-08 562 1.49123716220063 -1.7221787744378 -1 10.8669021529602 1506 2899 3303 3070 2489 1041 592 1016 864 3956 562 1161 M13342 GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. 12/24 Gene Ontology BP GO:0031272 1.38232699086008e-06 1.9484906054141e-06 330 1789.63636363636 1506 1.25666169038089e-07 289 1.79022888400406 -1.876411620565 -1 12.2604052637709 327 3074 2533 3888 3271 680 289 917 631 2570 1506 1162 M10532 GO_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASODILATION.html Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels. 45/71 Gene Ontology BP GO:0042312 1.6870246026137e-07 4.56114205459707e-07 1705 1332.81818181818 1509 1.53365884725429e-08 362 2.55023214593694 2.61690504406063 1 19.4540062754504 1702 457 362 427 1636 1509 3341 2133 1721 475 898 1163 M12371 GO_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BEHAVIOR.html Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 48/91 Gene Ontology BP GO:0050795 5.07537077700016e-07 8.9335897397218e-07 2810 1739.36363636364 1509 4.6139744980744e-08 334 2.58458445400495 3.09541595428275 1 18.8048620191159 2810 498 582 1509 2596 3676 3775 334 1789 513 1051 1164 M13963 GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. 24/29 Gene Ontology BP GO:0045683 9.87091830957152e-07 1.47815807653987e-06 2615 1663.63636363636 1510 8.97356612585384e-08 175 2.94214832216558 -2.33520698180503 -1 20.6424950533236 2612 822 839 788 3069 3243 2578 1709 175 955 1510 1165 M14086 GO_DETECTION_OF_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_BIOTIC_STIMULUS.html The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. 38/76 Gene Ontology BP GO:0009595 8.92213237325374e-07 1.36741376590084e-06 2515 1581.90909090909 1510 8.11103271967246e-08 17 1.53833300260394 -1.53954466667875 -1 10.806941415871 17 2513 2505 2513 2996 141 213 323 3853 1510 817 1166 M16157 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. 46/60 Gene Ontology BP GO:0040018 1.50888665072239e-07 4.37436111265502e-07 1950 1437.81818181818 1510 1.37171523110049e-08 151 2.09262850602532 -2.38316622546172 -1 15.9907385175097 1946 458 1614 162 1510 2768 2718 151 361 2640 1488 1167 M11956 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. 370/470 Gene Ontology BP GO:0032970 4.48939247668966e-08 4.02645553947883e-07 2120 1478.27272727273 1511 4.08126597118336e-09 179 2.11501708187159 2.35876324295544 1 16.2549845519282 2117 1511 266 688 179 2313 3876 1588 1116 197 2410 1168 M10927 GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. 96/145 Gene Ontology BP GO:0048704 1.4153373083341e-06 1.98959652437419e-06 755 1567.90909090909 1512 1.28667110806468e-07 122 2.25837568494617 2.60399655837844 1 15.4686745253479 752 122 477 1409 3279 1731 2774 1979 2583 629 1512 1169 M12630 GO_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 104/139 Gene Ontology BP GO:0055076 4.06275407849133e-08 4.02645553947883e-07 435 1443.54545454545 1514 3.69341286683496e-09 141 1.80125917455985 -1.83397324943802 -1 13.8283215220956 435 2409 2752 3165 141 338 282 1539 1514 2264 1040 1170 M14239 GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. 155/300 Gene Ontology BP GO:0051480 8.68800623506454e-16 4.75591682491239e-14 2095 1624.27272727273 1514 7.89818748642229e-17 35 2.62234391095886 2.85145676303167 1 42.1496043195534 2094 1717 48 35 755 1514 3986 3939 2480 86 1213 1171 M10409 GO_SINGLE_ORGANISM_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. 107/146 Gene Ontology BP GO:0044801 1.47971537841288e-07 4.36901586057683e-07 1515 2117.54545454545 1515 1.34519588903476e-08 668 1.7119622370494 -1.48107372469059 -1 13.0642627382273 1515 2411 3148 2505 1479 668 976 4116 1210 3772 1493 1172 M11842 GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. 26/54 Gene Ontology BP GO:0021522 1.58690279932542e-06 2.19784872643696e-06 790 1617.90909090909 1515 1.44263994908222e-07 185 2.38138536222897 2.37307962896572 1 16.192321243086 787 3267 1987 2465 3327 866 750 209 1515 2439 185 1173 M13316 GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 18/43 Gene Ontology BP GO:2000516 5.26858903061433e-08 4.02645553947883e-07 1190 1469 1515 4.78962650617019e-09 282 2.70552255917966 -2.7048545196387 -1 20.8220656590617 1186 1025 1604 1576 282 2361 1916 1515 1248 2335 1111 1174 M14999 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. 45/62 Gene Ontology BP GO:2000649 8.57557557508614e-08 4.02645553947883e-07 2030 1367.36363636364 1515 7.79597809941922e-09 175 2.15642702313665 -2.13862893848943 -1 16.5752568739756 2026 482 1385 2197 830 2045 1562 175 1719 1515 1105 1175 M11267 GO_CELLULAR_COMPONENT_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MAINTENANCE.html The organization process that preserves a cellular component in a stable functional or structural state. 23/26 Gene Ontology BP GO:0043954 8.27486614700179e-07 1.29000766299311e-06 1520 1573.81818181818 1516 7.52260841766468e-08 305 2.16925969232378 -2.00222795367191 -1 15.3478851061852 1516 2966 2277 1753 2939 1457 685 346 305 2019 1049 1176 M12058 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation. 133/174 Gene Ontology BP GO:0030856 3.11437673800396e-07 6.41771256064323e-07 2240 1558.27272727273 1516 2.83125198080295e-08 358 2.36694656759664 -1.99245220932957 -1 17.6239047220894 2239 1796 358 1077 2199 1944 1457 2818 1516 519 1218 1177 M13341 GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of chondrocyte differentiation. 52/71 Gene Ontology BP GO:0032330 1.06592252361573e-07 4.02645553947883e-07 2575 1903.63636363636 1516 9.69020522964342e-09 1096 2.35432997329639 2.83152179797531 1 18.1058757411212 2573 1904 1256 1113 1096 2806 3715 1516 1408 2254 1299 1178 M13852 GO_DICARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSPORT.html The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 68/107 Gene Ontology BP GO:0006835 2.96226460051691e-07 6.18645295610645e-07 2615 1519.09090909091 1516 2.69296818125558e-08 275 2.34753975097468 -2.26093431100273 -1 17.5238117776195 2615 275 674 1471 2169 2009 1516 1732 607 871 2771 1179 M10696 GO_SALIVARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SALIVARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. 48/55 Gene Ontology BP GO:0007431 2.94283958289642e-07 6.16248090873855e-07 1520 1483.45454545455 1517 2.67530906958792e-08 406 2.4993157847442 2.78237725279834 1 18.6685360139074 1517 406 634 573 2164 1886 3561 1863 877 998 1839 1180 M14229 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. 23/32 Gene Ontology BP GO:1902547 1.06052701825684e-06 1.56109845490322e-06 1415 1601.18181818182 1517 9.64115935902215e-08 124 2.80215024600046 2.87483011102058 1 19.5750021086305 1411 2604 1377 1517 3124 1538 2864 217 815 2022 124 1181 M11130 GO_GLIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DEVELOPMENT.html The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 86/123 Gene Ontology BP GO:0021782 7.9441998526966e-08 4.02645553947883e-07 2895 1909.27272727273 1518 7.22200012687423e-09 175 2.27727899775838 2.55611370939777 1 17.5099489153955 2895 175 977 1130 721 3110 4164 1921 1387 1518 3004 1182 M13690 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER.html The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. 21/39 Gene Ontology BP GO:0048791 6.09741130382627e-06 7.44847854993532e-06 3645 2088.72727272727 1518 5.54311654834159e-07 386 2.46126424263309 -2.59399910045764 -1 15.1610839733263 3641 888 871 1470 3780 3225 2722 1518 386 640 3835 1183 M12057 GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 90/106 Gene Ontology BP GO:0010812 4.87498514285571e-07 8.6875932093863e-07 800 1620.54545454545 1520 4.43180565736831e-08 429 2.52778207827335 2.41687333420329 1 18.426389737084 797 2425 429 778 2564 860 2419 3283 2103 648 1520 1184 M15620 GO_PROTEIN_CHROMOPHORE_LINKAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHROMOPHORE_LINKAGE.html The covalent or noncovalent attachment of a chromophore to a protein. 6/12 Gene Ontology BP GO:0018298 8.36915866198013e-07 1.30022354771932e-06 1555 1907.54545454545 1520 8.36916181390855e-08 561 2.54600502958571 -2.52931836070481 -1 18.0207559709302 1555 1281 4563 2851 3016 1383 561 726 2035 1520 1492 1185 M10787 GO_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_PROLIFERATION.html The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. 18/25 Gene Ontology BP GO:0043616 2.18762521640731e-06 2.91913396384951e-06 1565 1722.54545454545 1522 1.98875217430035e-07 680 3.44376758103003 3.50425982727287 1 22.9486136048534 1561 2178 680 2707 3456 1406 2197 707 1468 1522 1066 1186 M16512 GO_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. 8/16 Gene Ontology BP GO:0036149 7.18655842370156e-07 1.15227623519929e-06 1485 2079 1522 7.1865607478006e-08 571 2.31630924667124 -2.24147184023555 -1 16.5326308063644 1481 1254 4628 2400 2908 1522 571 661 4121 2200 1123 1187 M14755 GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic hydroxy compound. 157/247 Gene Ontology BP GO:1901617 1.36950084650949e-07 4.2456917914303e-07 1140 1561.27272727273 1523 1.24500084705543e-08 948 2.04446443246258 -1.90268968694375 -1 15.6523847141739 1139 1746 1023 1905 1399 1523 1333 1549 2654 948 1955 1188 M16001 GO_POSITIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 117/178 Gene Ontology BP GO:0050921 6.27377934718147e-08 4.02645553947883e-07 1450 1552.36363636364 1523 5.70343593281088e-09 342 2.40154310039752 2.50630592568277 1 18.4710310006037 1447 1822 342 2224 443 1281 2555 1523 2821 643 1975 1189 M12122 GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. 15/29 Gene Ontology BP GO:0048557 7.1551975099654e-07 1.14953625930237e-06 1810 1644.63636363636 1524 6.50472712463278e-08 679 2.20047268637704 2.71758790808351 1 15.7034513948389 1806 1077 1576 1417 2854 2305 2333 679 1524 1367 1153 1190 M12916 GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. 184/216 Gene Ontology BP GO:0071559 3.1399653855512e-07 6.44191311242051e-07 1280 1820.72727272727 1525 2.85451439427731e-08 774 2.0825674186696 2.27233196494501 1 15.4899762075634 1280 2374 1040 1399 2208 1525 3573 2464 2587 804 774 1191 M16780 GO_MITOTIC_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CHROMOSOME_CONDENSATION.html The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. 15/15 Gene Ontology BP GO:0007076 1.35241289384891e-06 1.91386167733545e-06 645 1736.63636363636 1525 1.22946702292967e-07 400 1.80963544885466 1.97520345194401 1 12.4114715264342 645 2675 2949 2876 3257 841 683 400 1525 2678 574 1192 M14034 GO_SYNAPTIC_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_SIGNALING.html Cell-cell signaling to or from a synapse. 337/577 Gene Ontology BP GO:0099536 2.60462721227774e-16 1.49621363194177e-14 2835 1807.54545454545 1526 2.36784292025248e-17 44 2.36112365869744 2.64609808025059 1 39.3748550155213 2832 1526 44 669 1097 2255 4585 3234 1419 123 2099 1193 M15391 GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 22/39 Gene Ontology BP GO:0032891 1.0760514590976e-06 1.57945345084578e-06 935 1879 1526 9.78229077645557e-08 934 2.83311406540252 2.91366419873167 1 19.7750499342305 934 2609 1324 2717 3134 1165 1501 1293 2620 1846 1526 1194 M13775 GO_VOCALIZATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOCALIZATION_BEHAVIOR.html The behavior in which an organism produces sounds by a mechanism involving its respiratory system. 19/36 Gene Ontology BP GO:0071625 3.47183755050643e-07 6.90656696131099e-07 2575 1424.45454545455 1527 3.15621645309091e-08 106 3.0271566883691 3.07710071755965 1 22.4517203719143 2574 902 448 106 2281 1527 1882 2745 722 463 2019 1195 M15213 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that activates or increases the rate or extent of osteoblast proliferation. 18/22 Gene Ontology BP GO:0033690 1.04307248129999e-07 4.02645553947883e-07 4005 2189.27272727273 1528 9.48247755231407e-09 252 3.1515248069897 2.70524075513463 1 24.2715314438636 4005 1022 1141 252 1065 2897 4420 4507 606 1528 2639 1196 M10528 GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/20 Gene Ontology BP GO:0010766 2.91095994775819e-07 6.11498719499722e-07 3845 1804.45454545455 1529 2.64632757538717e-08 195 2.35189609925461 -2.94149412281801 -1 17.5708751036912 3842 1042 1529 227 2157 3775 1865 195 825 1366 3026 1197 M13591 GO_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 105/157 Gene Ontology BP GO:0006633 2.44048869905238e-08 3.39987841817087e-07 1025 1581 1530 2.21862611465913e-09 31 1.97729443626056 -2.06434911470323 -1 15.3654778460262 1022 1830 1517 2379 31 1530 772 1654 2973 1340 2343 1198 M16753 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. 12/16 Gene Ontology BP GO:2000727 4.35121073801313e-06 5.46750838886716e-06 275 1727.54545454545 1530 3.95565394905628e-07 155 2.04764382567307 2.04764382567307 1 12.9284593210115 274 3372 2399 2800 3679 290 155 266 1530 3505 733 1199 M10722 GO_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that modulates the frequency, rate or extent of developmental growth. 335/478 Gene Ontology BP GO:0048638 4.15855295365669e-10 9.21416518731647e-09 2015 1383.72727272727 1531 3.78050268585705e-11 45 2.28668047166546 2.51533022492492 1 22.1193816137539 2011 1531 143 45 629 1672 3393 2556 842 292 2107 1200 M11255 GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 90/124 Gene Ontology BP GO:0051341 9.88664429365901e-08 4.02645553947883e-07 1835 1571.81818181818 1531 8.98785885268891e-09 192 2.12115135276439 -2.11397300311715 -1 16.3024281638457 1835 192 1619 2591 988 1684 1156 1531 3053 1467 1174 1201 M11938 GO_RESPONSE_TO_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METAL_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. 355/517 Gene Ontology BP GO:0010038 7.59931807311208e-10 1.59998312190907e-08 4070 2158.81818181818 1532 6.90847097794277e-11 152 2.48363281108191 2.57539758887964 1 23.3135323525734 4069 1532 152 404 1000 3621 4143 2802 1461 573 3990 1202 M12284 GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. 24/25 Gene Ontology BP GO:1901798 1.53547255479796e-07 4.39394452489232e-07 925 2065.54545454545 1532 1.39588423815005e-08 179 1.95984939259087 2.20156921842497 1 14.964981265232 923 4228 2988 4331 1532 597 179 626 3998 2882 437 1203 M12003 GO_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MOTILITY.html Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. 851/1223 Gene Ontology BP GO:0048870 4.77995574754031e-25 1.05910162349072e-22 1535 1704.72727272727 1533 4.77995574754032e-26 11 2.37301367396876 2.49613100374699 1 62.9636347338381 1533 1361 4338 283 508 1642 3740 1350 1983 11 2003 1204 M12505 GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of T cell tolerance induction. 24/53 Gene Ontology BP GO:0002664 1.76345069589094e-05 2.0106189874983e-05 70 1950.63636363636 1534 1.60314984664984e-06 70 1.16063058933629 -1.15759584604272 -1 6.48958699472577 70 852 3144 2546 4053 460 385 1254 3974 3185 1534 1205 M14712 GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT.html The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. 13/16 Gene Ontology BP GO:0072531 2.15421705568827e-06 2.87868235500217e-06 1715 1578 1535 1.95838105916185e-07 559 2.21782721101798 -2.02483187951469 -1 14.7587829743574 1714 1131 1788 2392 3451 1535 911 559 847 1818 1212 1206 M16162 GO_ACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase (MAPK). 157/224 Gene Ontology BP GO:0000187 5.17207745598976e-08 4.02645553947883e-07 1640 1355.09090909091 1535 4.70188870689312e-09 253 2.16126103815859 -1.99946008248813 -1 16.6126440609311 1640 1751 866 253 265 1587 1380 1535 2897 1131 1601 1207 M16578 GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. 23/33 Gene Ontology BP GO:0045940 5.36875313936948e-08 4.02645553947883e-07 1860 1275.81818181818 1535 4.88068479125947e-09 248 2.30405182764002 -2.4899100992524 -1 17.7170150481168 1856 878 1550 248 305 2282 1535 488 1784 1317 1791 1208 M13808 GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. 77/130 Gene Ontology BP GO:0017158 3.89536382224459e-07 7.45890035592759e-07 2335 1669.27272727273 1536 3.5412404654233e-08 218 2.16391894468785 -1.88148754354775 -1 15.9324839708933 2331 218 1013 730 2382 1536 1499 3231 2019 763 2640 1209 M14035 GO_MITOTIC_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_CHECKPOINT.html A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. 164/191 Gene Ontology BP GO:0007093 9.85606937174077e-08 4.02645553947883e-07 815 1763.45454545455 1536 8.96006346663254e-09 214 1.80971449573928 1.96285799639065 1 13.893716576159 815 3431 3037 2930 986 214 782 1536 1622 2810 1235 1210 M16306 GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of a defense response. 369/564 Gene Ontology BP GO:0031349 2.54564505832538e-07 5.65745344301423e-07 705 1732.72727272727 1536 2.3142230480772e-08 704 1.94132937410262 -2.01730066630806 -1 14.5648796989082 704 2773 1091 1536 2032 1790 1408 1339 3176 1388 1823 1211 M11796 GO_MEMBRANE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a membrane. 32/40 Gene Ontology BP GO:0071709 3.41946516345239e-07 6.84715782949634e-07 1780 1354.27272727273 1537 3.10860517721889e-08 89 2.47832243309006 2.61709780132938 1 18.3737225873407 1777 625 772 89 2267 1649 1537 2994 367 615 2205 1212 M12976 GO_REGULATION_OF_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METAL_ION_TRANSPORT.html Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 307/505 Gene Ontology BP GO:0010959 1.36311979004057e-14 6.09865036832575e-13 4305 2086.54545454545 1537 1.2391998091278e-15 63 2.33065344181161 2.51637494274035 1 34.3266338110712 4304 1537 63 349 330 3197 4571 2903 1327 137 4234 1213 M14227 GO_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of B cell activation. 102/269 Gene Ontology BP GO:0050864 1.40161724541767e-07 4.26814466160235e-07 1065 1904.09090909091 1537 1.27419757701321e-08 1065 2.04514558508659 -1.98624746217346 -1 15.651968189293 1065 2832 1703 2938 1425 1537 1227 1257 3905 1450 1606 1214 M11306 GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. 20/24 Gene Ontology BP GO:0060644 4.99783402956699e-07 8.86239395563079e-07 4090 2077.81818181818 1538 4.54348651358787e-08 148 2.46485781400909 1.44825636803272 1 17.9393470544585 4089 944 1538 777 2577 4057 3958 1214 148 2276 1278 1215 M12397 GO_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 53/76 Gene Ontology BP GO:0090183 9.9594620913032e-08 4.02645553947883e-07 2760 1686.81818181818 1538 9.05405685651901e-09 325 2.5133165121603 2.57825888879582 1 19.3355077188702 2760 366 423 482 996 2080 3971 3919 1538 325 1695 1216 M11582 GO_RESPONSE_TO_GRAVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GRAVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. 14/20 Gene Ontology BP GO:0009629 3.41578867298246e-08 3.99952679980378e-07 3070 1628.63636363636 1539 3.10526247819733e-09 41 3.85093970081423 -5.25890943348987 -1 29.6945113894078 3067 1110 883 41 90 2855 1539 4243 63 1565 2459 1217 M12959 GO_REGULATION_OF_CHEMOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_SECRETION.html Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell. 13/20 Gene Ontology BP GO:0090196 1.49440521494416e-06 2.08499774067022e-06 2110 1765.36363636364 1539 1.35855111823398e-07 959 2.97381533291814 -3.2811678600343 -1 20.3285173337367 2106 1155 959 1539 3303 2224 2461 1303 1643 1380 1346 1218 M13601 GO_REGULATION_OF_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS.html Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. 19/27 Gene Ontology BP GO:0042481 1.54643430409012e-07 4.40634342739212e-07 2060 1514 1540 1.40584946617529e-08 352 3.68763645171702 3.70393832622674 1 28.2432942543283 2058 978 648 2201 1540 1996 2939 352 1014 1345 1583 1219 M11017 GO_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 38/43 Gene Ontology BP GO:0060996 6.6674531045355e-07 1.09238236955647e-06 1020 1648.63636363636 1542 6.06132284110458e-08 863 1.88933966915463 2.18627002761997 1 13.519131740103 1019 1968 2093 2321 2795 951 1205 863 1542 2361 1017 1220 M11217 GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. 55/75 Gene Ontology BP GO:0070228 1.10169134083143e-07 4.02645553947883e-07 2660 1659.27272727273 1543 1.00153763272791e-08 399 2.49997123946137 -2.6018919968441 -1 19.2322928543939 2660 399 757 956 1150 3312 2286 1912 1543 1025 2252 1221 M14842 GO_THALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THALAMUS_DEVELOPMENT.html The process in which the thalamus changes over time, from its initial formation to its mature state. 17/31 Gene Ontology BP GO:0021794 6.40277275686935e-07 1.06547346577944e-06 745 1249.36363636364 1543 5.82070420027443e-08 217 2.41004933977675 2.29999733666276 1 17.3050070659102 744 2182 1543 1605 2754 217 338 1719 655 1750 236 1222 M11856 GO_REGULATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 296/473 Gene Ontology BP GO:0042391 1.90955173156058e-15 9.98330809769816e-14 3475 2024.54545454545 1544 1.73595611960052e-16 51 2.53143028679011 2.86017458415346 1 39.6988291866632 3472 1544 51 348 531 2227 4183 4537 1168 175 4034 1223 M14731 GO_BEHAVIORAL_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_COCAINE.html Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. 8/15 Gene Ontology BP GO:0048148 3.09248389427108e-09 5.71005061906482e-08 505 1829.72727272727 1544 3.09248389857464e-10 1 3.67648853205338 3.80946919616963 1 32.1034507943992 501 3094 4515 1357 3659 1161 1544 1 2249 1586 460 1224 M14446 GO_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_REGENERATION.html The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. 36/47 Gene Ontology BP GO:0031102 2.2431101121264e-07 5.22174902015509e-07 2270 1648.63636363636 1545 2.03919121893903e-08 506 2.41735459349307 2.36320664289583 1 18.2632723770909 2270 614 1078 1060 1931 1545 2503 3410 506 1113 2105 1225 M15585 GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 30/49 Gene Ontology BP GO:0032350 1.36480658693016e-07 4.23928240920297e-07 4255 1978.27272727273 1545 1.24073333781656e-08 607 2.58587105929772 2.8127707405538 1 19.8267013436003 4252 741 717 1104 1397 4504 3074 1766 1545 607 2054 1226 M11231 GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS.html The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 51/987 Gene Ontology BP GO:0007606 2.52515253625731e-08 3.44992641396772e-07 2955 1708.54545454545 1547 2.29559324112812e-09 38 2.59087305564425 -2.65876479974932 -1 20.1456364791305 2951 404 518 1464 38 2163 2839 3823 1547 788 2259 1227 M11323 GO_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATRIX_ADHESION.html The binding of a cell to the extracellular matrix via adhesion molecules. 145/186 Gene Ontology BP GO:0007160 1.2187414165347e-07 4.13625369156524e-07 305 1635 1547 1.10794680368157e-08 256 2.41542341453636 2.46548722605156 1 18.5442518391961 304 2810 256 1714 2428 1228 2942 1380 2793 583 1547 1228 M12560 GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. 303/340 Gene Ontology BP GO:0051056 5.30232901254394e-08 4.02645553947883e-07 4485 2160.63636363636 1547 4.82029921848909e-09 290 2.07281064406215 -1.68700919587167 -1 15.9285519748798 4484 1547 492 680 290 3717 3072 3385 1401 467 4232 1229 M16408 GO_REGULATION_OF_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROPTOTIC_PROCESS.html Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. 16/18 Gene Ontology BP GO:0060544 6.26955188670202e-08 4.02645553947883e-07 3600 1683.45454545455 1547 5.69959278670135e-09 442 1.91541682138002 -2.04328659748018 -1 14.7112383654819 3597 1020 1823 1807 442 2572 1458 755 1415 1547 2082 1230 M13218 GO_GALACTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. 16/16 Gene Ontology BP GO:0006012 4.88943252204469e-08 4.02645553947883e-07 1550 1510.54545454545 1548 4.44493875519166e-09 233 2.01566850188419 -1.83584132851192 -1 15.4866038338536 1548 1070 2569 2674 233 1750 1646 787 1060 2415 864 1231 M13516 GO_PIGMENT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. 36/41 Gene Ontology BP GO:0050931 3.19169482393518e-07 6.51643528555085e-07 1555 1413 1548 2.901541169979e-08 631 2.23162669316754 -1.92884489080549 -1 16.5925550751323 1552 631 1386 1109 2221 1627 1158 1707 1565 1548 1039 1232 M16068 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. 17/30 Gene Ontology BP GO:1901380 9.40318771308759e-08 4.02645553947883e-07 2735 1748.36363636364 1548 8.54835283181493e-09 869 2.56531609050131 -2.29371585572844 -1 19.7376822980167 2734 985 1252 1548 929 2249 869 3464 899 1753 2550 1233 M16287 GO_MESODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the mesoderm. 9/23 Gene Ontology BP GO:0001710 1.41525203964638e-07 4.2854237685504e-07 1040 2150.63636363636 1549 1.41525212977861e-08 277 2.3254579128113 2.56549192026918 1 17.8064395869247 1038 3604 4612 3496 1549 777 998 1171 3672 2463 277 1234 M12032 GO_NEGATIVE_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_AGING.html Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 22/27 Gene Ontology BP GO:0090344 2.52679195539241e-06 3.31467802888099e-06 1550 1975.27272727273 1550 2.29708623411205e-07 366 2.22771729928448 2.69025782999069 1 14.6600438040888 1550 4234 2842 1884 3515 912 366 1134 729 3813 749 1235 M14725 GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to another cell. 209/357 Gene Ontology BP GO:0022409 8.52000767016708e-08 4.02645553947883e-07 1615 1688.54545454545 1551 7.74546181829458e-09 314 1.9174828284145 -1.78478953345159 -1 14.7272172548521 1612 1637 719 1527 811 1301 1551 3447 3489 314 2166 1236 M13712 GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT.html A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. 117/132 Gene Ontology BP GO:0044774 1.55964124971167e-07 4.41300019561337e-07 1165 2066.90909090909 1552 1.41785578207181e-08 715 1.84818440064216 2.07451209519351 1 14.102264892677 1162 3659 3181 2983 1552 715 1166 2155 1502 3200 1461 1237 M14045 GO_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 273/420 Gene Ontology BP GO:0006631 5.30043220065726e-08 4.02645553947883e-07 490 1390.90909090909 1552 4.81857484396355e-09 288 1.89313911839683 -1.81540493417782 -1 14.5389383948387 490 1589 1819 2358 288 894 878 1225 2515 1552 1692 1238 M15924 GO_MODULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 303/448 Gene Ontology BP GO:0050804 2.96259432706347e-09 5.4920125114846e-08 3115 1895.90909090909 1552 2.69326757368456e-10 179 2.29734289276686 2.72634157875047 1 20.0689749700883 3113 1552 179 465 1244 2574 4403 3046 1434 340 2505 1239 M11944 GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION.html The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. 9/13 Gene Ontology BP GO:0017187 1.41829265191457e-07 4.2854237685504e-07 2075 1853 1553 1.41829274243451e-08 3 4.50211626118755 -5.86419447294423 -1 34.5698645968193 2075 1210 4334 31 1553 1455 455 4545 3 2452 2270 1240 M15864 GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of stem cell proliferation. 73/102 Gene Ontology BP GO:2000648 2.54784276587113e-07 5.65745344301423e-07 1115 1458.63636363636 1553 2.31622096449044e-08 135 2.11334869004469 2.45406482101277 1 15.8645825759406 1115 1871 1553 273 2034 1415 2409 1750 2594 896 135 1241 M13040 GO_PROTEIN_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CARBOXYLATION.html The addition of a carboxy group to a protein amino acid. 9/13 Gene Ontology BP GO:0018214 1.41829265191457e-07 4.2854237685504e-07 2080 1861.09090909091 1554 1.41829274243451e-08 4 4.50211626118755 -5.86419447294423 -1 34.5698645968193 2076 1211 4403 32 1554 1456 456 4552 4 2457 2271 1242 M13340 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 274/356 Gene Ontology BP GO:0090068 2.35073178389734e-07 5.3972042302237e-07 595 1557.36363636364 1554 2.13702912279679e-08 359 1.81916611123873 1.91164688389071 1 13.6868640368464 595 2351 2419 2468 1963 359 662 1554 2498 1419 843 1243 M12404 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 465/586 Gene Ontology BP GO:0044089 6.98128465342403e-08 4.02645553947883e-07 3200 2058.27272727273 1555 6.34662261360174e-09 383 2.10028480893994 2.3609429884389 1 16.1410423651801 3196 1469 383 531 570 3143 4470 2834 1555 989 3501 1244 M13456 GO_DNA_REPLICATION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INITIATION.html The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. 29/31 Gene Ontology BP GO:0006270 3.42416430232857e-05 3.80708160065349e-05 10 1741.63636363636 1555 3.11292508954111e-06 8 1.54625339454726 1.54625339454726 1 8.16148836818045 8 2922 2729 2409 4285 216 48 941 3005 1040 1555 1245 M11626 GO_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 753/1387 Gene Ontology BP GO:0050776 1.42040405648623e-07 4.2854237685504e-07 1315 1877.18181818182 1556 1.42040414727588e-08 582 1.975857778455 -1.92796928474969 -1 15.1140117008015 1314 1390 4317 1074 1556 1606 1488 2690 2916 582 1716 1246 M12014 GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. 21/25 Gene Ontology BP GO:0046621 5.48627870290529e-08 4.02645553947883e-07 1900 1516.27272727273 1556 4.98752621792734e-09 82 2.89663088763986 3.90414697324489 1 22.3001336361875 1899 2126 1540 626 324 1332 1556 2466 82 2835 1893 1247 M16440 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. 82/112 Gene Ontology BP GO:1901019 6.60422876857636e-08 4.02645553947883e-07 2130 1424.27272727273 1556 6.00384451530015e-09 160 2.30971127455247 2.38324746525909 1 17.7607862815159 2130 160 830 512 496 1556 3113 2540 1851 887 1592 1248 M14733 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 79/93 Gene Ontology BP GO:0090003 4.71136140697558e-08 4.02645553947883e-07 3475 1963.72727272727 1557 4.28305591624609e-09 198 1.9275845751441 -1.70067892456458 -1 14.8053460756856 3474 198 1557 578 207 3664 2818 3593 553 1550 3409 1249 M15210 GO_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS.html Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. 92/117 Gene Ontology BP GO:0050764 8.54625736292618e-08 4.02645553947883e-07 1500 1687.63636363636 1558 7.76932517719951e-09 732 2.34215376148931 -2.17707790992988 -1 18.0117026148124 1498 2421 1024 1108 820 1580 1558 2980 1572 732 3271 1250 M12060 GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. 78/125 Gene Ontology BP GO:1901616 1.58748860566503e-07 4.44738738572283e-07 1560 1532 1559 1.44317156383269e-08 869 2.15591397227528 -2.15712653737914 -1 16.4586978320473 1559 1851 1183 1491 1572 1213 1793 869 2098 1311 1912 1251 M15365 GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS.html Any apoptotic process that contributes to the shaping of an anatomical structure. 23/28 Gene Ontology BP GO:0060561 3.50600081724107e-07 6.95371773342826e-07 1395 1643.63636363636 1559 3.18727397815487e-08 699 2.33349813767704 2.52306573463047 1 17.2750842867698 1393 2108 1740 1442 2289 1147 1425 1559 699 2024 2254 1252 M16301 GO_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that modulates the frequency, rate or extent of neutrophil migration. 31/60 Gene Ontology BP GO:1902622 6.57256603299252e-07 1.08447339544377e-06 2215 1717.09090909091 1560 5.97506181506106e-08 665 2.69911031939709 -3.27094066858592 -1 19.3678583259381 2213 709 665 1325 2776 2260 1560 2431 2927 1031 991 1253 M16681 GO_SYNCYTIUM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNCYTIUM_FORMATION.html The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. 31/57 Gene Ontology BP GO:0006949 9.68051020796193e-07 1.45536124794109e-06 1290 1845.27272727273 1560 8.8004676978305e-08 328 2.6993091257131 3.18193874458685 1 18.9522416180572 1289 2028 934 2679 3058 1560 2315 328 3461 1266 1380 1254 M14190 GO_POSITIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GROWTH.html Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. 289/393 Gene Ontology BP GO:0045927 5.12390415671177e-08 4.02645553947883e-07 4325 2183.90909090909 1561 4.65809479640904e-09 79 2.16556174208193 2.20117364049877 1 16.6459065189275 4325 1561 360 79 259 3737 4268 3896 1323 725 3490 1255 M15977 GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. 117/146 Gene Ontology BP GO:0031098 6.66293263392609e-08 4.02645553947883e-07 1045 2056.63636363636 1561 6.05721166883643e-09 507 1.59609751378749 -1.5756147323245 -1 12.2415624134536 1042 1827 3375 3510 507 1364 1269 821 4014 3333 1561 1256 M11452 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. 18/24 Gene Ontology BP GO:2000725 1.9495561266426e-07 4.93024708629241e-07 580 1649.36363636364 1562 1.77232390854987e-08 576 1.88842020768058 1.84549749043106 1 14.3015864497696 576 2652 2370 2794 1758 658 611 682 1562 3146 1334 1257 M16354 GO_REGULATION_OF_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of organ morphogenesis. 239/309 Gene Ontology BP GO:2000027 6.87845331975947e-08 4.02645553947883e-07 1830 1564.27272727273 1562 6.25313957710827e-09 544 2.08186917480005 2.31699593201663 1 15.9986123658181 1826 2358 991 1393 544 1119 2401 2467 1580 966 1562 1258 M11016 GO_RESPONSE_TO_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANGIOTENSIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. 21/29 Gene Ontology BP GO:1990776 3.54234281524207e-08 4.00785157005513e-07 4620 2110 1564 3.2203117020721e-09 105 2.53313157255617 2.26320607807367 1 19.4949228241511 4618 936 1564 638 105 3973 4349 803 609 2064 3551 1259 M11074 GO_CELLULAR_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. 44/63 Gene Ontology BP GO:0006879 3.95153572029817e-08 4.02645553947883e-07 520 1626.18181818182 1565 3.59230526479435e-09 135 1.66026460030101 -1.68297303668388 -1 12.7378428033521 520 2514 2893 3689 135 559 362 1565 2006 2726 919 1260 M11388 GO_MONOVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 289/504 Gene Ontology BP GO:0015672 8.6142707602937e-08 4.02645553947883e-07 2225 1853.09090909091 1566 7.83115554326564e-09 269 2.30360444368635 -2.1816520164004 -1 17.7135548959574 2222 1566 269 3124 835 3161 2956 1231 1424 672 2924 1261 M12815 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that stops or decreases the rate or extent of glial cell proliferation. 14/16 Gene Ontology BP GO:0060253 3.30394652242896e-07 6.67532052490749e-07 1640 1605.09090909091 1568 3.00358819873976e-08 213 1.62962423784935 -1.61159244050621 -1 12.068162966935 1639 1075 2052 2309 2247 1531 671 1210 3141 1568 213 1262 M14770 GO_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 58/98 Gene Ontology BP GO:0014902 6.10762131235651e-07 1.02780332609023e-06 1570 1700.36363636364 1568 5.55238455268165e-08 563 2.53643911156129 3.18496209113606 1 18.2658837896421 1568 1891 611 2383 2723 1371 2547 760 3029 1258 563 1263 M13373 GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. 44/58 Gene Ontology BP GO:0030514 4.76031182662976e-08 4.02645553947883e-07 2690 1874.72727272727 1569 4.32755629966576e-09 212 2.04608181183727 2.4991261223504 1 15.7218261283618 2688 523 1569 1825 212 2934 4635 1552 2854 1035 795 1264 M15300 GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a humoral immune response. 8/19 Gene Ontology BP GO:0002922 0.000106133922430191 0.000113552803188706 715 2149.09090909091 1569 1.06138991755216e-05 509 3.25822825779507 -3.25822825779507 -1 15.4415058219034 714 1275 4547 2898 4339 867 509 1569 3471 2821 630 1265 M13787 GO_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell. 134/260 Gene Ontology BP GO:0050707 7.08967581138686e-08 4.02645553947883e-07 2900 1734.54545454545 1570 6.44516003623393e-09 47 2.55584912214507 -2.927855334918 -1 19.6644629732466 2896 1795 249 47 580 3741 3584 1570 1155 308 3155 1266 M14448 GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. 29/36 Gene Ontology BP GO:0060351 0.000216605524994333 0.000228333825962536 160 1866.63636363636 1570 1.96933503888089e-05 158 2.85308586485833 3.00975004579228 1 12.4618482008461 158 2034 612 997 4395 1570 2602 3045 3004 857 1259 1267 M14754 GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. 278/471 Gene Ontology BP GO:0034110 7.56307837461873e-08 4.02645553947883e-07 2085 1817.90909090909 1571 6.8755260314722e-09 252 1.98208836117748 -1.83163777286327 -1 15.2268886710144 2085 1571 525 1322 655 1454 1895 4584 3169 252 2485 1268 M16211 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. 65/115 Gene Ontology BP GO:0032755 2.49545673621075e-07 5.59830093920551e-07 2950 1774.54545454545 1574 2.26859729024552e-08 319 2.2715096427513 -2.36477940710991 -1 17.0721177919436 2947 319 993 954 2012 3227 2866 1204 1574 1260 2164 1269 M16074 GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. 205/259 Gene Ontology BP GO:0030178 1.58994763730529e-07 4.44738738572283e-07 1420 1625.72727272727 1575 1.44540704746488e-08 977 1.84971327150723 2.22179580059075 1 14.1064747724042 1416 1678 2119 1426 1575 977 2004 1072 1380 2531 1705 1270 M16696 GO_CENTROSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_LOCALIZATION.html Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. 31/32 Gene Ontology BP GO:0051642 4.77886343601523e-07 8.57210931679987e-07 1575 1552.72727272727 1575 4.34442224916849e-08 311 1.78298674396726 2.24998594211116 1 12.9793644039966 1575 702 2429 2039 2545 1559 1681 311 1494 2128 617 1271 M13323 GO_HEART_VALVE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_FORMATION.html The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. 21/24 Gene Ontology BP GO:0003188 1.59008264067826e-07 4.44738738572283e-07 3460 2033.90909090909 1576 1.44552977782168e-08 357 2.63624210419171 3.04940929210903 1 20.1485617195405 3459 836 510 1284 1576 3437 4090 4154 791 357 1879 1272 M14047 GO_ACTIVATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_IMMUNE_RESPONSE.html Any process that initiates an immune response. 389/757 Gene Ontology BP GO:0002253 9.9638025070835e-08 4.02645553947883e-07 1125 1772.54545454545 1576 9.0580026894039e-09 997 1.96481927351755 -2.02338931465747 -1 15.0933262790978 1122 1525 1505 2445 997 1935 1576 1627 2939 2402 1425 1273 M10212 GO_VIRAL_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_BUDDING.html A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. 25/25 Gene Ontology BP GO:0046755 1.59046907583125e-07 4.44738738572283e-07 95 1809.54545454545 1577 1.44588108255701e-08 36 0.946642048836803 -0.908925895709393 -1 7.16911326690389 75 2085 3768 4160 1577 92 36 93 3928 3981 110 1274 M10413 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION.html The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. 8/21 Gene Ontology BP GO:0021843 1.8725430485326e-06 2.54541127806667e-06 1405 1915.09090909091 1577 1.87254462642233e-07 144 3.49051453675865 4.23652783120117 1 23.5126818392479 1402 1255 4238 1375 3426 1950 3162 144 313 1577 2224 1275 M10772 GO_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ASSEMBLY.html Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. 308/403 Gene Ontology BP GO:0030031 3.09080604855228e-08 3.82848241393431e-07 1260 1652.72727272727 1577 2.80982371997762e-09 70 1.84709522707568 1.87014368379505 1 14.2317396503696 1258 2344 2142 2364 70 801 1388 2859 1577 1427 1950 1276 M11086 GO_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. 254/310 Gene Ontology BP GO:0007009 3.48124241462744e-08 3.99952679980378e-07 4550 2112.09090909091 1577 3.16476588155821e-09 222 2.21411164568464 2.57979438720569 1 17.0292043918462 4547 1577 222 343 420 4190 3054 3841 624 246 4169 1277 M13592 GO_HEART_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_FORMATION.html The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. 13/18 Gene Ontology BP GO:0060914 4.94107141679475e-06 6.1472741450123e-06 1580 1968.27272727273 1577 4.49189319471569e-07 147 3.16557553552081 2.68787273878754 1 19.8482511643201 1577 3044 1504 1537 3716 1099 612 2972 147 2785 2658 1278 M16170 GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. 55/62 Gene Ontology BP GO:0060603 6.89285519367476e-07 1.11672894206715e-06 1900 1823.81818181818 1577 6.2662339575338e-08 660 2.53707486946074 2.86338009533615 1 18.1599121591283 1896 2866 1061 660 2827 1023 1577 4042 826 2062 1222 1279 M13432 GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION.html An organelle organization which involves another organism. 25/25 Gene Ontology BP GO:1902590 1.59046907583125e-07 4.44738738572283e-07 80 1814.54545454545 1578 1.44588108255701e-08 37 0.946642048836803 -0.908925895709393 -1 7.16911326690389 76 2086 3769 4161 1578 93 37 138 3929 3982 111 1280 M10790 GO_INDOLALKYLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLALKYLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. 8/18 Gene Ontology BP GO:0006586 6.46243122930702e-07 1.07207164843688e-06 365 1653.90909090909 1579 6.46243310864357e-08 362 2.88881988364613 -2.88881988364613 -1 20.7538348660112 362 3097 4262 1964 2848 504 411 509 2022 1579 635 1281 M14497 GO_LIPID_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 85/112 Gene Ontology BP GO:0046834 1.51334346164766e-07 4.37569031250903e-07 3360 2008.18181818182 1579 1.37576687795277e-08 182 2.0017403432392 -1.92212803031522 -1 15.2914290475549 3358 182 1258 1565 1514 2516 2926 4115 1046 2031 1579 1282 M15650 GO_MULTI_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves another organism. 25/25 Gene Ontology BP GO:1902592 1.59046907583125e-07 4.44738738572283e-07 80 1819.09090909091 1579 1.44588108255701e-08 38 0.946642048836803 -0.908925895709393 -1 7.16911326690389 77 2087 3770 4162 1579 94 38 178 3930 3983 112 1283 M11933 GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. 12/17 Gene Ontology BP GO:0003161 2.52273550548171e-07 5.63037951909527e-07 3310 1644.63636363636 1580 2.29339617705757e-08 316 2.70074683455647 -1.75718206452924 -1 20.3095112931241 3307 2235 1580 982 2023 2598 1011 1347 316 1595 1097 1284 M15895 GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. 23/31 Gene Ontology BP GO:0050849 3.253092000175e-07 6.61542813507306e-07 1175 1568.63636363636 1581 2.95735680109338e-08 500 1.64654154585137 2.01918313429745 1 12.2023070792473 1171 845 2326 2244 2232 850 1581 672 2809 2025 500 1285 M11467 GO_REGULATION_OF_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXIT_FROM_MITOSIS.html Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. 23/27 Gene Ontology BP GO:0007096 1.19714824783184e-07 4.10861475461767e-07 1585 1624.09090909091 1582 1.0883166481597e-08 253 1.58551916825078 1.5420873876349 1 12.142925993769 1582 2116 3052 1658 1237 727 253 1103 2040 3393 704 1286 M12613 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION.html The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. 8/21 Gene Ontology BP GO:0021826 1.8725430485326e-06 2.54541127806667e-06 1405 1929.09090909091 1582 1.87254462642233e-07 146 3.49051453675865 4.23652783120117 1 23.5126818392479 1403 1256 4377 1376 3427 1951 3163 146 314 1582 2225 1287 M16840 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. 53/108 Gene Ontology BP GO:0046635 8.04893437755831e-07 1.26270032564999e-06 240 1719 1582 7.31721574758927e-08 240 1.69029057166625 -1.56483370723915 -1 11.9553583554007 240 428 2568 2536 2920 728 1075 1582 3280 2102 1450 1288 M13050 GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 79/104 Gene Ontology BP GO:0010517 1.5990545843919e-07 4.46003173442602e-07 3390 1798.18181818182 1583 1.45368609147098e-08 204 2.6033630333446 -2.83713386877195 -1 19.8921037827355 3389 204 305 221 1583 4489 3872 732 2569 276 2140 1289 M13798 GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION.html The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. 111/170 Gene Ontology BP GO:0099531 2.74856406268362e-07 5.87732931234691e-07 1950 1525.90909090909 1584 2.49869491461344e-08 53 2.0019412351812 -1.92699042748104 -1 14.9827446825969 1947 53 810 83 2117 1042 1584 4400 1805 594 2350 1290 M10201 GO_INORGANIC_ION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_IMPORT_INTO_CELL.html The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 17/26 Gene Ontology BP GO:0099587 3.7249505412565e-08 4.02645553947883e-07 1940 1598.81818181818 1586 3.38631873120532e-09 99 2.46079440617611 -2.5028951633486 -1 18.9292918120495 1939 1016 1586 1350 117 1938 995 4301 99 2589 1657 1291 M11296 GO_INORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSPORT.html The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 81/147 Gene Ontology BP GO:0015698 2.35847087283085e-07 5.40178690738178e-07 2860 1492.18181818182 1586 2.14406465969688e-08 162 2.4057621567133 -2.59139001056246 -1 18.1323646233086 2860 162 508 341 1968 2854 2330 1586 498 959 2348 1292 M14110 GO_BLOOD_VESSEL_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_REMODELING.html The reorganization or renovation of existing blood vessels. 34/45 Gene Ontology BP GO:0001974 8.36158885553331e-07 1.29948139428178e-06 1590 1661.90909090909 1586 7.60144730322058e-08 292 2.9123689834946 3.22035195681971 1 20.6295878346643 1586 1981 511 1353 2951 1582 3257 292 2376 621 1771 1293 M12093 GO_INORGANIC_CATION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_IMPORT_INTO_CELL.html The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 17/26 Gene Ontology BP GO:0098659 3.7249505412565e-08 4.02645553947883e-07 1940 1607.81818181818 1587 3.38631873120532e-09 100 2.46079440617611 -2.5028951633486 -1 18.9292918120495 1940 1017 1587 1351 118 1939 996 4386 100 2594 1658 1294 M12531 GO_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 52/57 Gene Ontology BP GO:0034333 8.8488139431463e-08 4.02645553947883e-07 1925 1973.45454545455 1588 8.04437663551113e-09 146 2.3120009919831 2.54600749020941 1 17.7784953894241 1921 440 1394 895 861 3024 4345 4619 146 2475 1588 1295 M14572 GO_PERICARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. 25/30 Gene Ontology BP GO:0060039 8.16947925788503e-08 4.02645553947883e-07 4530 2083.27272727273 1588 7.42679960113678e-09 261 2.24700802968349 -1.64666147718466 -1 17.2758275199095 4528 856 1588 261 766 4491 2651 980 420 1972 4403 1296 M14943 GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. 21/29 Gene Ontology BP GO:1900271 2.16665884626642e-07 5.13962042198191e-07 980 1824.18181818182 1588 1.96969005422613e-08 827 2.92705895179742 2.78882808776238 1 22.1602036380805 979 3289 1560 1588 1890 1166 827 1299 3462 1693 2313 1297 M12015 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. 34/44 Gene Ontology BP GO:0002832 5.99092829405547e-08 4.02645553947883e-07 1830 1516.45454545455 1591 5.44629859745215e-09 404 2.37850325652214 -2.40388042947262 -1 18.2928364880748 1828 2006 2094 1591 404 1551 840 1952 674 3091 650 1298 M16215 GO_DNA_PACKAGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING.html Any process in which DNA and associated proteins are formed into a compact, orderly structure. 152/328 Gene Ontology BP GO:0006323 1.18826357621751e-06 1.7128223110719e-06 195 1525.45454545455 1591 1.08024019820244e-07 85 1.81062070236265 1.94888475547687 1 12.5238275504929 192 2385 2640 2866 3189 85 203 388 2683 1591 558 1299 M11050 GO_LYMPHOCYTE_COSTIMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_COSTIMULATION.html The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. 55/114 Gene Ontology BP GO:0031294 2.28639571884354e-08 3.26596701964021e-07 2600 1701.63636363636 1592 2.07854158418671e-09 23 1.98391879371154 -1.90495900282521 -1 15.4591728087255 2598 387 1592 960 23 1695 1371 3089 1769 1573 3661 1300 M14023 GO_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 140/211 Gene Ontology BP GO:0042471 3.12049491982868e-07 6.42462958493931e-07 1595 1592.54545454545 1592 2.83681396585626e-08 274 2.40222397161365 2.56516221249851 1 17.8867499551204 1592 1776 274 556 2250 1803 4342 2408 1568 520 429 1301 M14660 GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 15/35 Gene Ontology BP GO:0032660 5.83094605960929e-07 9.93823883346594e-07 1510 1663 1593 5.30086145914665e-08 160 2.21611441901088 -1.91644571762391 -1 15.9852306961584 1508 2215 1927 1437 2688 940 160 2102 1593 2676 1047 1302 M11780 GO_DORSAL_VENTRAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_PATTERN_FORMATION.html The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 73/135 Gene Ontology BP GO:0009953 8.15303681143893e-08 4.02645553947883e-07 1870 1481.54545454545 1594 7.41185192144039e-09 306 2.16702068415847 2.144716967387 1 16.6571902530337 1869 306 1420 2279 761 907 2296 1594 1884 1892 1089 1303 M10104 GO_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DEVELOPMENT.html The progression of an endothelial cell over time, from its formation to the mature structure. 64/70 Gene Ontology BP GO:0001885 1.1620446875102e-07 4.08548528935279e-07 4025 1995.54545454545 1595 1.05640431717241e-08 320 1.98421846980263 -2.11463627131788 -1 15.2281953929107 4025 320 1595 720 1208 4380 2376 1911 1000 1511 2905 1304 M10865 GO_BETA_AMYLOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). 16/25 Gene Ontology BP GO:0050435 2.62789259656841e-05 2.947115992247e-05 595 1599.18181818182 1596 2.38902180652908e-06 217 1.51217532526238 -1.57067238406029 -1 8.18270287104206 591 2659 2974 2026 4126 636 217 418 1596 1992 356 1305 M12450 GO_CELL_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. 239/292 Gene Ontology BP GO:0034330 1.91930355339503e-17 1.37392606676109e-15 2205 1576.36363636364 1596 1.74482141217731e-18 33 2.72370612331631 2.96768356496498 1 48.8532291475193 2202 1596 33 280 890 2297 3617 2723 354 153 3195 1306 M14288 GO_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_POLYMERIZATION.html Assembly of actin filaments by the addition of actin monomers to a filament. 28/38 Gene Ontology BP GO:0030041 6.9649974638961e-07 1.12723941563508e-06 1060 1660.45454545455 1596 6.33181788086468e-08 179 2.4051564435706 -2.41213000236029 -1 17.1984769668992 1057 2941 1859 1596 2830 1292 664 179 2805 2370 672 1307 M12416 GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. 12/27 Gene Ontology BP GO:1901533 2.85966890437261e-07 6.03154693443602e-07 2145 1447.81818181818 1597 2.59969934189691e-08 28 1.7934449628906 -2.40675651133054 -1 13.3872150234089 1322 1159 2141 2115 2145 1969 893 345 2212 1597 28 1308 M13919 GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 268/336 Gene Ontology BP GO:0006650 1.84142786503075e-07 4.7749337740829e-07 810 1441.09090909091 1597 1.67402547196419e-08 181 1.80761759921513 -1.79691727207787 -1 13.7156281540103 808 1597 2301 1924 1711 181 1070 1305 1904 2793 258 1309 M15438 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. 28/30 Gene Ontology BP GO:0033137 1.65332824866845e-08 2.57288840837937e-07 2120 1505.45454545455 1597 1.50302569190312e-09 8 2.17795527264621 2.29978156636853 1 17.254081176248 2116 797 1597 1564 8 1486 2231 1803 934 2371 1653 1310 M13232 GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. 47/68 Gene Ontology BP GO:0033628 3.21122082434289e-08 3.86093294461692e-07 2940 1568.54545454545 1598 2.91929170110485e-09 81 2.25570537406848 -2.1783064697971 -1 17.3928284411829 2938 469 848 1805 81 2542 1598 2714 1176 937 2146 1311 M12791 GO_POLYOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSPORT.html The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/22 Gene Ontology BP GO:0015791 1.1860662053475e-07 4.09676049985113e-07 3785 1775.18181818182 1599 1.07824206299166e-08 122 3.92183162515596 -3.89027207468374 -1 30.1935734526876 3783 1161 763 398 1229 3656 1650 1693 122 1599 3473 1312 M13534 GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. 10/22 Gene Ontology BP GO:0021514 8.5695640245735e-06 1.02162903936307e-05 1685 1669 1599 7.79054309582222e-07 570 2.39880967483633 2.19576188909359 1 14.3756517073235 1685 2267 1440 1613 3876 1599 728 570 1837 1154 1590 1313 M14022 GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that increases the extent to which blood vessels can be pervaded by fluid. 8/13 Gene Ontology BP GO:0043117 1.90341554584716e-07 4.86893487346171e-07 505 1499 1600 1.90341570888176e-08 33 2.12833060716849 2.12833060716849 1 16.14557063007 504 2301 4466 1600 1853 238 33 60 2984 2197 253 1314 M13140 GO_CHEMOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of chemicals. 16/29 Gene Ontology BP GO:0007635 2.86696760994423e-07 6.04166679758628e-07 1605 1750.63636363636 1601 2.60633453050735e-08 43 2.48487224967277 3.39492318095365 1 18.5858967791288 1601 1065 1237 1793 3340 2131 2593 43 3397 1540 517 1315 M12859 GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT.html The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. 34/54 Gene Ontology BP GO:0048566 5.10640128937119e-07 8.96606988658269e-07 1670 1732.45454545455 1602 4.64218406783093e-08 653 2.47884094500322 2.5216580382134 1 18.0265583804201 1666 653 859 1378 2604 1777 2306 3885 1602 926 1401 1316 M14329 GO_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE.html Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. 824/1745 Gene Ontology BP GO:0006955 5.81617639322825e-14 2.35327554414705e-12 985 1846.54545454545 1602 5.8161763932284e-15 71 2.21833510825016 -2.1979997953857 -1 31.0940834091083 981 1375 4487 1689 1358 1602 1426 2465 2829 71 2029 1317 M11667 GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 395/602 Gene Ontology BP GO:0045088 9.16994308952032e-07 1.39894246542748e-06 725 1867.72727272727 1604 8.33631537427076e-08 725 1.79166185731964 -1.76216061238054 -1 12.5821050738123 725 2772 2308 1604 3012 1143 933 1466 3212 2328 1042 1318 M13869 GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 80/131 Gene Ontology BP GO:0042345 8.52792887944629e-07 1.31960269624422e-06 1210 2243.09090909091 1604 7.75266562286896e-08 1082 2.20400259826939 -1.97830615820906 -1 15.5690883788841 1207 3673 2621 3795 2966 1604 1595 1089 1082 3649 1393 1319 M15212 GO_MEMBRANE_PROTEIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. 44/63 Gene Ontology BP GO:0033619 1.41703332453696e-07 4.2854237685504e-07 1755 1865.81818181818 1604 1.28821219618995e-08 172 1.8724495304637 -1.31984457760874 -1 14.3176182696046 1754 3211 2480 3226 1435 1167 779 1604 1487 3209 172 1320 M11633 GO_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_SECRETION.html The controlled release of a peptide from a cell or a tissue. 55/82 Gene Ontology BP GO:0002790 4.90548521263622e-08 4.02645553947883e-07 3155 1716.18181818182 1605 4.45953211092461e-09 238 2.42482446004887 -2.33710728332896 -1 18.6510934418478 3151 400 1117 758 238 2718 1605 2727 1437 1804 2923 1321 M13073 GO_ENDODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. 55/73 Gene Ontology BP GO:0035987 2.26932002104663e-06 3.01076513401563e-06 215 1753.54545454545 1605 2.0630203289766e-07 213 2.49944130295138 2.6543766235072 1 16.5869952864091 213 1894 334 919 3669 1605 2691 2957 3122 550 1335 1322 M15939 GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS.html The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. 12/15 Gene Ontology BP GO:0003222 1.31386878852125e-06 1.86726679077256e-06 3570 2038.27272727273 1605 1.19442688471049e-07 274 2.39260945988445 -2.25453305730918 -1 16.4739683570967 3569 1141 1463 1179 3242 2783 674 2697 274 1605 3794 1323 M11278 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY.html Any process that increases the activity of triglyceride lipase. 4/15 Gene Ontology BP GO:0061365 5.42087176511169e-07 9.38716647676394e-07 870 1783.54545454545 1607 5.42087308747542e-08 196 1.41933457826213 -1.41933457826213 -1 10.2434245796605 866 2758 4291 2543 2704 468 196 554 1607 3106 526 1324 M11555 GO_REGULATION_OF_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of tolerance induction. 28/59 Gene Ontology BP GO:0002643 6.60415462326447e-06 7.99613100755909e-06 3820 1873.45454545455 1607 6.00379495298489e-07 113 1.30834785105043 -1.26323188860719 -1 7.96227860666225 113 747 2870 2529 3817 654 542 1196 3820 2713 1607 1325 M12886 GO_REGULATION_OF_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCRINE_PROCESS.html Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 35/62 Gene Ontology BP GO:0044060 3.46554272150814e-08 3.99952679980378e-07 1770 1468.72727272727 1607 3.15049343281726e-09 95 2.34999364334068 -2.29224633034116 -1 18.0806203975546 1766 1996 1359 2408 95 1607 1088 254 2909 2027 647 1326 M12302 GO_LIPOPROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_TRANSPORT.html The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/19 Gene Ontology BP GO:0042953 1.38084292009193e-07 4.24835370983751e-07 990 1732.18181818182 1608 1.25531182432851e-08 797 2.44824512641235 2.73388535037869 1 18.7632509426966 988 3356 2004 2332 1407 990 797 1608 2250 2038 1284 1327 M15274 GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that activates or increases the frequency, rate or extent of blood circulation. 83/135 Gene Ontology BP GO:1903524 5.43514016247261e-08 4.02645553947883e-07 2100 1629.63636363636 1608 4.94103663340795e-09 188 2.59467675430531 2.40647871426247 1 19.9647632280082 2100 188 288 753 319 1608 3311 4035 2830 419 2075 1328 M14433 GO_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANOIKIS.html Any process that modulates the frequency, rate or extent of anoikis. 48/78 Gene Ontology BP GO:2000209 5.5686010794379e-08 4.02645553947883e-07 3670 2303 1609 5.06236474580851e-09 344 2.1692444318409 2.1855698545449 1 16.6743891384254 3669 463 1589 1401 344 4502 3244 4603 870 1609 3039 1329 M12552 GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 129/187 Gene Ontology BP GO:0042990 1.08634381035295e-07 4.02645553947883e-07 1695 2225.63636363636 1610 9.87585330905285e-09 1012 1.85860224720902 -1.75507462168354 -1 14.2718236974096 1692 3654 2977 4226 1127 1012 1515 1460 1610 3804 1405 1330 M14895 GO_CELL_MIGRATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_IN_HINDBRAIN.html The orderly movement of a cell that will reside in the hindbrain. 15/24 Gene Ontology BP GO:0021535 5.24931413128424e-07 9.17545403939352e-07 1210 1932.81818181818 1610 4.77210489436204e-08 541 1.64961526321048 2.09600742071433 1 11.9418436051461 1208 3023 2925 2544 2616 1272 1610 541 1438 3135 949 1331 M16481 GO_DEVELOPMENTAL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. 228/357 Gene Ontology BP GO:0021700 7.53852502486492e-10 1.59439804275893e-08 2405 1591.54545454545 1610 6.85320457040734e-11 48 2.17875036784547 2.48446525499099 1 20.4430040727385 2404 1610 151 48 402 1648 3960 3585 2123 177 1399 1332 M10763 GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 48/78 Gene Ontology BP GO:0090218 2.54795105378032e-07 5.65745344301423e-07 2125 1659.18181818182 1611 2.31631940806705e-08 579 2.14273029062756 -2.04495764037815 -1 16.0865771269607 2123 1907 1321 1033 2035 1611 579 2749 1236 1364 2293 1333 M10667 GO_MEMBRANE_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. 36/45 Gene Ontology BP GO:0044091 3.09861664614674e-07 6.39656754858952e-07 1690 1268.90909090909 1612 2.81692462052295e-08 86 2.44726094443943 2.64277476736991 1 18.2296482934676 1689 556 795 86 2195 1612 1859 1969 300 760 2137 1334 M15641 GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 137/250 Gene Ontology BP GO:0050777 2.02044139558937e-07 4.97676750327016e-07 650 1547.27272727273 1612 1.83676507376653e-08 521 2.12650044370152 -1.97162048877039 -1 16.1071320525879 650 1786 521 1133 1813 1539 1612 1769 3558 759 1880 1335 M10113 GO_LIPID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_MODIFICATION.html The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. 198/244 Gene Ontology BP GO:0030258 7.41875956163722e-08 4.02645553947883e-07 1615 1681.45454545455 1613 6.74432710164537e-09 635 1.81165068958193 -1.60088140648276 -1 13.908691465738 1613 1677 2066 1568 635 794 2222 2921 1579 2466 955 1336 M14903 GO_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_SLEEP.html Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. 11/36 Gene Ontology BP GO:0030431 1.65416314198962e-07 4.52287618430271e-07 1060 1894 1613 1.50378478760445e-08 1056 2.5677791677141 2.76480271498471 1 19.5999316984552 1056 1218 1780 3882 1613 1308 1141 1077 4068 1869 1822 1337 M11230 GO_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_VIRUS.html Reactions triggered in response to the presence of a virus that act to protect the cell or organism. 175/318 Gene Ontology BP GO:0051607 3.81974342487464e-07 7.34129126639476e-07 610 2083.54545454545 1614 3.47249462552419e-08 607 2.10353552473895 -2.12940632276219 -1 15.5025800887912 607 3646 1526 3415 2372 1614 1483 1506 3358 1464 1928 1338 M10345 GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. 51/73 Gene Ontology BP GO:0046470 7.64134524066996e-07 1.21059514487018e-06 220 1188.09090909091 1615 6.94667990433573e-08 56 2.21009611107976 -2.21162359006666 -1 15.712501838709 216 1903 1615 2356 2893 56 114 235 1706 1670 305 1339 M15571 GO_RESPONSE_TO_SALT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. 12/19 Gene Ontology BP GO:1902074 6.03142349438197e-05 6.55705923349517e-05 1615 1993.18181818182 1615 5.48326259599057e-06 429 2.5599713389893 -3.34452662624975 -1 12.8486050680769 1615 3071 2162 1609 4367 2195 429 550 1047 3504 1376 1340 M16810 GO_AMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving AMP, adenosine monophosphate. 16/18 Gene Ontology BP GO:0046033 8.72068980757201e-07 1.34362151240505e-06 695 1876.63636363636 1615 7.92790296764699e-08 80 1.80514433339508 1.94757155142457 1 12.7158166316734 695 2679 2763 3224 4297 686 326 80 1615 3594 684 1341 M10678 GO_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 219/292 Gene Ontology BP GO:0002064 2.88472225519126e-09 5.39060749132729e-08 3575 1686.54545454545 1616 2.62247478088529e-10 28 2.25429589308961 -1.98255895521567 -1 19.7130651293091 3575 1616 177 28 37 3840 2699 3383 560 238 2399 1342 M10685 GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. 94/156 Gene Ontology BP GO:0045833 6.84234822984772e-08 4.02645553947883e-07 2070 1840.90909090909 1617 6.22031676605056e-09 536 1.98639300276745 -1.86776923906371 -1 15.2601815836697 2068 1844 1519 2038 536 1601 1546 3781 1617 2292 1408 1343 M13816 GO_NEGATIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BEHAVIOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 7/21 Gene Ontology BP GO:0048521 7.20563372105833e-07 1.15379683847004e-06 1610 1922.27272727273 1618 7.20563605751147e-08 144 2.64723829392413 -1.84908486721895 -1 18.9075089309273 1610 3101 4451 2246 2910 888 144 979 670 2528 1618 1344 M14324 GO_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. 358/578 Gene Ontology BP GO:0022407 1.95445018256132e-08 2.94306042053652e-07 2315 1766 1619 1.77677290902217e-09 164 2.07673025405266 -1.89058136288016 -1 16.3007542576493 2313 1521 230 1287 526 1619 2041 4571 2633 164 2521 1345 M10638 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. 221/330 Gene Ontology BP GO:0050688 4.70155462289621e-07 8.47768633581501e-07 690 1452.45454545455 1620 4.27414147968344e-08 687 2.06215174435526 -1.86464558150065 -1 15.0396807265887 687 2363 1309 1718 2531 861 800 1620 1656 1700 732 1346 M12548 GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 9/13 Gene Ontology BP GO:0043650 1.51184863217907e-07 4.37569031250903e-07 1145 1929.27272727273 1621 1.51184873503496e-08 250 2.1403239724013 1.79434795532059 1 16.3572066371238 1142 1239 4374 2891 1621 922 250 1082 3442 2456 1803 1347 M14007 GO_MICROTUBULE_BUNDLE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BUNDLE_FORMATION.html A process that results in a parallel arrangement of microtubules. 84/140 Gene Ontology BP GO:0001578 1.58438345047362e-07 4.44738738572283e-07 1540 2014 1621 1.44034869506987e-08 1304 2.18554214826796 2.08547507253684 1 16.6863004423951 1540 2843 1651 3663 1568 1500 1621 1564 1304 2325 2575 1348 M11506 GO_TOOTH_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOOTH_MINERALIZATION.html The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. 28/32 Gene Ontology BP GO:0034505 3.21699925452441e-05 3.5836000793158e-05 225 1793.09090909091 1622 2.92458754252662e-06 221 2.93730807527382 2.81744370576206 1 15.6897555704611 221 2554 461 930 4187 1622 2787 3066 1662 765 1469 1349 M15314 GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. 10/16 Gene Ontology BP GO:0072505 1.83833308179365e-07 4.7749337740829e-07 3110 1677 1622 1.67121203218716e-08 696 3.43080179136243 -3.71517571542295 -1 26.1242870910306 3106 1219 1207 1932 1708 2437 1390 1462 696 1622 1668 1350 M14322 GO_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULOGENESIS.html The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. 68/94 Gene Ontology BP GO:0001570 6.06770477517013e-07 1.02182520155145e-06 935 1599.27272727273 1623 5.51609677152058e-08 637 2.07288923330022 2.30690626719035 1 14.9152159144552 935 1880 1476 1867 2721 713 1623 2091 2657 992 637 1351 M16823 GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION.html A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. 27/30 Gene Ontology BP GO:0034629 8.04588017999577e-08 4.02645553947883e-07 1835 1626.72727272727 1624 7.31443679477378e-09 370 2.11012897931573 2.21134046501756 1 16.2171790417501 1832 820 2160 2020 737 1791 1624 4485 764 1291 370 1352 M10205 GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 18/30 Gene Ontology BP GO:0035588 1.80030487647409e-07 4.72066258868601e-07 1745 1674.27272727273 1625 1.6366409307243e-08 469 3.2195517322602 3.4510565717845 1 24.5286863621591 1742 951 469 875 1690 2258 3221 3537 1341 708 1625 1353 M16534 GO_BIOLOGICAL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOLOGICAL_ADHESION.html The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. 953/1424 Gene Ontology BP GO:0022610 4.13399887349572e-37 1.62823034379791e-33 1685 1720 1625 4.1339988734957e-38 1 2.52440603657041 2.69015754642467 1 100 1683 1338 4632 829 481 914 3694 1982 1625 1 1741 1354 M14540 GO_RESPONSE_TO_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 544/708 Gene Ontology BP GO:0070848 6.77225494993476e-08 4.02645553947883e-07 1685 1775.54545454545 1626 6.77225515632023e-09 637 2.01468529041129 2.21011908175182 1 15.478999490262 1682 1430 4500 925 643 885 3270 1685 2248 637 1626 1355 M16925 GO_DIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 214/346 Gene Ontology BP GO:0072511 1.18062996310023e-08 1.92758008156116e-07 2720 1670.09090909091 1626 1.07329997221462e-09 200 2.27727055089552 2.43808525095537 1 18.3909570154565 2717 1626 200 1243 412 1921 4034 1860 1601 286 2471 1356 M13374 GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. 38/57 Gene Ontology BP GO:2000179 5.38386839029096e-08 4.02645553947883e-07 4605 2010.27272727273 1628 4.89442592913244e-09 243 1.83282044394707 -1.5944059793047 -1 14.0724223521042 4602 610 1958 243 309 4073 3006 1628 992 910 3782 1357 M10471 GO_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 42/70 Gene Ontology BP GO:0051602 1.55344345212047e-07 4.41011127682522e-07 2170 1834.27272727273 1630 1.41222141982798e-08 515 2.09080119270768 -2.02566506266033 -1 15.9677468492288 2169 608 1630 1155 1547 1600 515 3402 1693 3069 2789 1358 M12668 GO_REGULATION_OF_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of heart morphogenesis. 28/47 Gene Ontology BP GO:2000826 8.31083804778891e-07 1.29408206566537e-06 1630 1778.72727272727 1630 7.55531017030667e-08 722 1.85091298121708 -1.64916509682942 -1 13.0773523137063 1630 2046 2147 1222 2944 1282 722 1183 3086 1715 1589 1359 M12864 GO_BONE_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MINERALIZATION.html The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. 41/53 Gene Ontology BP GO:0030282 7.42093163245524e-08 4.02645553947883e-07 3680 1794.90909090909 1630 6.74630171161316e-09 52 3.25870612059326 -2.97093955016888 -1 25.1004920059706 3680 560 500 52 640 3006 1720 3589 651 1630 3716 1360 M15683 GO_CARDIAC_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. 54/69 Gene Ontology BP GO:0060411 1.68055508118727e-07 4.555734802126e-07 3360 2141.54545454545 1631 1.52777746323907e-08 393 2.24770028696174 2.25732773267377 1 17.1353807495709 3359 393 915 1157 1631 2822 4599 3556 1033 505 3587 1361 M15950 GO_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 226/310 Gene Ontology BP GO:0007584 9.97861711920931e-11 2.52339703563483e-09 3330 2025.09090909091 1631 9.07147010878356e-12 128 2.58325851496036 2.73542958403259 1 26.7588382961576 2821 1631 128 486 1573 3327 3655 3329 1548 412 3366 1362 M16703 GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 10/13 Gene Ontology BP GO:0007260 3.6395458218708e-07 7.09757196528284e-07 1895 1707.81818181818 1631 3.30867856725018e-08 860 2.6354412426201 -2.5201310575317 -1 19.4953730735504 1894 1223 1533 1631 2331 1918 860 1400 2481 2157 1358 1363 M13315 GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. 16/20 Gene Ontology BP GO:0035358 1.68110824312279e-07 4.555734802126e-07 3005 2182.63636363636 1632 1.52828033780275e-08 1259 3.01415601116403 -1.98665038544637 -1 23.0135769366462 3005 2197 1384 1362 1632 3706 2617 3890 1259 1541 1416 1364 M16126 GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. 71/105 Gene Ontology BP GO:2000177 4.11506613282049e-08 4.02645553947883e-07 3220 1985.18181818182 1632 3.74096928162924e-09 143 1.87907590567301 2.15327416130328 1 14.430170846349 3218 272 1632 251 143 3358 4615 2650 1441 1321 2936 1365 M10616 GO_RESPONSE_TO_PROSTAGLANDIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 38/86 Gene Ontology BP GO:0034695 1.68416561128508e-07 4.55820858027515e-07 3525 2226.63636363636 1633 1.53105976383e-08 612 2.38404999439862 2.76490536314144 1 18.1804108825898 3521 612 1165 1373 1633 4627 2796 3153 1404 1507 2702 1366 M13312 GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 165/217 Gene Ontology BP GO:0010771 8.86212842777805e-08 4.02645553947883e-07 2525 1641.72727272727 1634 8.05648071342354e-09 419 2.23997169818325 2.50663339303992 1 17.2214072005507 2523 1715 419 504 862 1634 3143 3200 1021 610 2428 1367 M13890 GO_OOCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. 25/45 Gene Ontology BP GO:0001556 8.06761909011023e-08 4.02645553947883e-07 2695 1834.90909090909 1634 7.33419944177987e-09 742 2.35491371910928 2.54568584252914 1 18.1103905417045 2692 802 831 1550 742 2162 3356 1599 2423 1634 2393 1368 M11500 GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 48/76 Gene Ontology BP GO:0002755 8.13346745313101e-07 1.27381434060648e-06 640 1640.63636363636 1636 7.39406405463674e-08 504 2.4733628971547 -2.48508235389787 -1 17.5303115630532 638 3489 1686 1636 2928 1032 538 504 1929 2875 792 1369 M12192 GO_DETECTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS.html The series of events by which a mechanical stimulus is received and converted into a molecular signal. 55/82 Gene Ontology BP GO:0050982 4.73256285568586e-06 5.91316191393831e-06 360 1653.09090909091 1636 4.30233912385434e-07 360 2.49486526059284 2.54729360829046 1 15.6719436957739 360 1896 501 980 3699 1636 2977 2779 1883 548 925 1370 M16052 GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Ras protein signal transduction. 215/239 Gene Ontology BP GO:0046578 7.05354910116471e-08 4.02645553947883e-07 4240 2163 1636 6.41231757028425e-09 564 2.1875831820281 2.64029831702006 1 16.8162245027479 4239 1636 564 703 577 4323 3253 2712 1550 659 3577 1371 M16575 GO_POSITIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXONOGENESIS.html Any process that activates or increases the frequency, rate or extent of axonogenesis. 93/107 Gene Ontology BP GO:0050772 6.74060924148941e-08 4.02645553947883e-07 1405 1611.90909090909 1637 6.1278267709235e-09 522 2.35377094468899 2.81239516229906 1 18.1015521080825 1401 2419 984 1789 522 1637 3530 531 2062 1699 1157 1372 M13048 GO_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEARNING.html Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. 147/227 Gene Ontology BP GO:0007612 2.13084656343738e-07 5.11172703648005e-07 1640 1572.27272727273 1638 1.93713342711281e-08 756 2.10213115835426 2.25259866887778 1 15.8918251146175 1638 2813 1014 1829 1867 853 2832 785 1664 1244 756 1373 M16856 GO_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 19/37 Gene Ontology BP GO:0010453 6.23859675844794e-07 1.04365655495074e-06 1030 1578 1640 5.67145320685783e-08 601 2.25822130208505 2.43039660025814 1 16.2328808122953 1026 2144 1640 2116 2739 601 813 1396 2245 1731 907 1374 M11527 GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. 8/16 Gene Ontology BP GO:2000400 3.45334754853926e-07 6.88152570142299e-07 1470 2025.45454545455 1641 3.45334808519179e-08 976 2.45869926394486 2.71340539603263 1 18.220959965014 1468 2305 4308 3200 2366 1386 1289 1760 976 1581 1641 1375 M11446 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 41/63 Gene Ontology BP GO:0010719 1.43236830178813e-07 4.28892939253578e-07 4355 2031.90909090909 1642 1.3021530864057e-08 481 2.17769717856447 2.15214133627141 1 16.6675324223844 4351 567 1642 618 1455 3723 4316 1318 481 1885 1995 1376 M11994 GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of an acute inflammatory response. 51/97 Gene Ontology BP GO:0002673 1.67639234161909e-07 4.54825280790299e-07 1430 2361.45454545455 1642 1.52399315396328e-08 476 2.49116120085925 -3.08318610013017 -1 19.0047116882775 1428 4422 1445 4305 1630 2212 1642 476 4315 3125 976 1377 M12817 GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. 213/342 Gene Ontology BP GO:0050714 9.30623885255623e-08 4.02645553947883e-07 1750 1529.09090909091 1642 8.46021749656388e-09 161 2.15890882688557 -2.08474346279467 -1 16.5944516138195 1747 1642 567 161 919 2138 2426 1333 2195 526 3166 1378 M14203 GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epidermal cell differentiation. 54/67 Gene Ontology BP GO:0045604 1.85245627220788e-06 2.52031550718809e-06 1645 1818.18181818182 1642 1.68405257456844e-07 743 2.39996008882187 -1.87181182521114 -1 16.1468492855118 1642 1901 1351 2030 3390 1275 743 3301 1053 2430 884 1379 M15036 GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. 8/16 Gene Ontology BP GO:0033089 3.45334754853926e-07 6.88152570142299e-07 1470 2047.72727272727 1642 3.45334808519179e-08 977 2.45869926394486 2.71340539603263 1 18.220959965014 1469 2306 4532 3201 2367 1387 1290 1767 977 1587 1642 1380 M13227 GO_LOCALIZATION_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_OF_CELL.html Any process in which a cell is transported to, and/or maintained in, a specific location. 851/1223 Gene Ontology BP GO:0051674 4.77995574754031e-25 1.05910162349072e-22 1535 1743.09090909091 1643 4.77995574754032e-26 12 2.37301367396876 2.49613100374699 1 62.9636347338381 1534 1362 4415 284 509 1643 3741 1686 1984 12 2004 1381 M14554 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. 170/194 Gene Ontology BP GO:1901988 1.97939867460257e-07 4.93246485651519e-07 885 1864 1645 1.79945350244943e-08 444 1.85367142754675 2.00260290969223 1 14.0360908759629 882 2807 3024 3442 1788 444 853 1645 1640 2679 1300 1382 M10883 GO_ASSOCIATIVE_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASSOCIATIVE_LEARNING.html Learning by associating a stimulus (the cause) with a particular outcome (the effect). 70/113 Gene Ontology BP GO:0008306 1.20485906984778e-07 4.11313958327346e-07 1250 1553.90909090909 1646 1.09532648712135e-08 284 1.99087555400653 1.97443211626771 1 15.2725774066489 1500 2454 1739 2034 1246 430 1250 1896 2614 1646 284 1383 M15776 GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION.html The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. 26/35 Gene Ontology BP GO:0021799 1.30490554819412e-07 4.18739690741189e-07 2055 1805.45454545455 1646 1.18627784144832e-08 607 1.69083959484239 1.79641014390653 1 12.9395089567871 2055 850 2516 647 1347 2723 3866 607 801 2802 1646 1384 M15727 GO_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMPORT_INTO_CELL.html The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 35/59 Gene Ontology BP GO:0098657 1.70974240918791e-07 4.59245216956312e-07 605 1939.72727272727 1647 1.55431140187411e-08 601 2.5287416612608 -2.46324255163662 -1 19.2801160016473 3152 601 623 1278 1647 3407 2533 3806 604 1002 2684 1385 M14720 GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY.html A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. 70/97 Gene Ontology BP GO:0060135 8.51649929752702e-08 4.02645553947883e-07 4280 2081.63636363636 1648 7.74227238837484e-09 292 2.30342239473512 1.90375271494768 1 17.7121468949181 4278 292 1371 514 810 4228 4157 2285 602 1648 2713 1386 M11483 GO_CHONDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. 39/43 Gene Ontology BP GO:0002063 1.3809225322651e-05 1.59598423810967e-05 520 1649.18181818182 1650 1.2553920002567e-06 516 2.64430303531421 2.81051535362021 1 15.2378194046094 516 596 663 619 3998 1650 2626 2549 2046 986 1892 1387 M14217 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. 15/16 Gene Ontology BP GO:1904814 0.000721594829494334 0.000746792869581214 620 2322 1651 6.56210563311716e-05 119 1.15704985572365 1.15704985572365 1 4.2724764604332 618 4290 3709 3097 4483 849 119 1226 1150 4350 1651 1388 M12188 GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 17/21 Gene Ontology BP GO:0010893 8.83932427029894e-07 1.35606250674912e-06 1145 1510.90909090909 1652 8.03575256530057e-08 343 2.11241812068272 -2.16156482473657 -1 14.8876173995829 1144 2190 2118 1652 2991 1453 649 343 1808 1747 525 1389 M12267 GO_ECTODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. 28/39 Gene Ontology BP GO:0007398 2.95298073952596e-07 6.17360494577655e-07 2455 1832.27272727273 1652 2.68452830535818e-08 420 2.41290831781726 -1.8309596447256 -1 18.0172738579863 2454 2039 1393 1081 2166 3171 3248 420 1124 1407 1652 1390 M13900 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that activates, maintains or increases the rate of developmental growth. 195/260 Gene Ontology BP GO:0048639 4.54621102623782e-08 4.02645553947883e-07 4550 2171.27272727273 1652 4.13291920016676e-09 67 2.27780695543009 2.36420738331565 1 17.5140322399377 4549 1652 314 67 187 4300 4225 3721 924 715 3230 1391 M14356 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING.html Any cell surface receptor signaling pathway that is involved in cell-cell signaling. 45/99 Gene Ontology BP GO:1905114 4.20251483999074e-08 4.02645553947883e-07 2585 1726.90909090909 1653 3.82046810933509e-09 156 2.18089408475644 2.22978266110955 1 16.7644897586226 2581 499 1390 629 156 1653 2848 2908 1452 2054 2826 1392 M16917 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. 34/64 Gene Ontology BP GO:0045620 1.20204289036389e-06 1.72893526085415e-06 1655 2041.54545454545 1654 1.09276686103668e-07 731 2.10335296940759 -2.58920952198367 -1 14.554920105481 1654 731 2206 3942 3194 1864 1526 1040 3382 1627 1291 1393 M12268 GO_HYALURONAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 37/45 Gene Ontology BP GO:0030212 5.43093634602547e-07 9.39700311675655e-07 1785 1644.45454545455 1655 4.9372160788281e-08 210 2.0809640933366 2.10684821297478 1 15.0652948471733 1782 627 1406 2862 2642 576 210 1655 3301 1201 1827 1394 M12634 GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). 30/46 Gene Ontology BP GO:0007205 8.76553631541442e-08 4.02645553947883e-07 2610 1821.90909090909 1655 7.96866969514796e-09 157 2.76884980469298 2.82362413335541 1 21.3118505597356 2609 713 1079 733 855 2940 3276 4346 157 1678 1655 1395 M12386 GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION.html Any process that activates or increases the frequency, rate or extent of vasoconstriction. 23/45 Gene Ontology BP GO:0045907 2.90448998582537e-07 6.10415171817771e-07 1410 1778.45454545455 1657 2.6404457902571e-08 1269 2.53002354484102 2.29091874973114 1 18.9118091547942 1409 2104 1269 2066 2155 1404 1359 1561 2815 1657 1764 1396 M14126 GO_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_METABOLIC_PROCESS.html The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 194/392 Gene Ontology BP GO:0008202 1.72085431324287e-07 4.60444802732551e-07 1650 1659.81818181818 1657 1.56441313440838e-08 1044 2.21239796960673 -2.11396880232533 -1 16.8522766035566 1648 2370 1072 1908 1657 1044 1667 1583 1677 2030 1602 1397 M16799 GO_RESPONSE_TO_LEPTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEPTIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. 23/27 Gene Ontology BP GO:0044321 1.62257203736853e-05 1.8609385481577e-05 1335 1884.90909090909 1657 1.47507636772016e-06 308 2.13903030668199 -2.10697432189934 -1 12.1339501108657 1331 2978 1967 1657 4269 1176 1324 308 2496 2740 488 1398 M12989 GO_ORGANELLE_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_FUSION.html The joining of two lipid bilayers to form a single organelle membrane. 82/104 Gene Ontology BP GO:0090174 1.72210528836348e-07 4.60514707284785e-07 1540 2048.90909090909 1658 1.56555038469601e-08 434 1.57735424647369 -1.3034792708011 -1 11.9853432654974 1536 2439 3170 2452 1658 434 601 4130 1270 3290 1558 1399 M11069 GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of epithelial cell migration. 210/251 Gene Ontology BP GO:0010632 6.65804547891987e-08 4.02645553947883e-07 1910 1744.54545454545 1659 6.05276880037992e-09 126 2.15706607361174 2.12936858315609 1 16.5801994112821 1909 1640 432 126 506 1659 2819 4558 1713 393 3435 1400 M10461 GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. 15/23 Gene Ontology BP GO:0003148 4.50962483203499e-05 4.96176030821916e-05 1820 1899.27272727273 1660 4.09974297664239e-06 158 2.05673401556521 2.14844659762531 1 10.6037550000345 1819 2685 2296 1660 4201 1516 877 1366 1187 3127 158 1401 M12722 GO_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. 422/660 Gene Ontology BP GO:0050708 5.05070722792271e-10 1.10333055077579e-08 3095 1888.72727272727 1660 4.59155202643838e-11 38 2.19377237646662 -2.15873522502383 -1 21.0088778920245 3094 1490 155 38 691 3428 3033 3415 1660 122 3650 1402 M13514 GO_REGULATION_OF_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of ion homeostasis. 188/303 Gene Ontology BP GO:2000021 6.44042355618084e-10 1.38737457439396e-08 2745 1983.36363636364 1662 5.85493050733294e-11 148 2.34846843059543 2.53048757521668 1 22.2150309119934 2744 1662 148 853 1153 1557 3780 4585 2585 281 2469 1403 M14962 GO_ENDODERM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_FORMATION.html The formation of the endoderm during gastrulation. 63/84 Gene Ontology BP GO:0001706 9.68814045802323e-07 1.45536124794109e-06 325 1748.54545454545 1662 8.80740429490224e-08 311 2.37791124998681 2.62084021457152 1 16.68340158194 325 1875 311 924 3060 1662 2745 3189 3198 458 1487 1404 M14212 GO_LIPOPROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_LOCALIZATION.html Any process in which a lipoprotein is transported to, or maintained in, a specific location. 14/19 Gene Ontology BP GO:0044872 1.38084292009193e-07 4.24835370983751e-07 990 1738.72727272727 1663 1.25531182432851e-08 798 2.44824512641235 2.73388535037869 1 18.7632509426966 989 3357 2005 2333 1408 991 798 1663 2251 2046 1285 1405 M16624 GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of cation transmembrane transport. 207/316 Gene Ontology BP GO:1904062 8.87847541292134e-08 4.02645553947883e-07 4120 2256.45454545455 1663 8.07134161020669e-09 245 2.30459111908828 -1.99820927617757 -1 17.7211860302317 4120 1634 245 452 865 3506 4061 4283 1663 460 3532 1406 M10732 GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS.html The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. 29/43 Gene Ontology BP GO:0060441 1.50637720895366e-06 2.09981220888597e-06 1915 1534.45454545455 1664 1.36943476399691e-07 27 2.54569323733682 3.04835421286102 1 17.3776554362197 1913 699 1150 151 3306 1664 1976 2732 27 1532 1729 1407 M10982 GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 33/54 Gene Ontology BP GO:0090184 4.53399110261602e-08 4.02645553947883e-07 3685 2124.81818181818 1665 4.1218101782339e-09 182 2.41419727102438 2.25035316465376 1 18.5689007508723 3683 632 672 722 182 2703 4365 3974 1665 275 4500 1408 M11561 GO_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the meiotic cell cycle. 44/61 Gene Ontology BP GO:0051445 2.42175558191551e-07 5.50444561636596e-07 1005 1488.27272727273 1665 2.20159622591084e-08 530 1.82571381985685 1.74320321687324 1 13.7176307358129 1001 535 2179 2257 1984 560 530 1665 1701 2727 1232 1409 M15481 GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 75/104 Gene Ontology BP GO:0046916 2.24280963771576e-08 3.2409295789725e-07 760 1616.45454545455 1666 2.0389178732548e-09 21 1.88663129160092 -1.87193124322352 -1 14.7036621785338 758 2446 2603 3161 21 963 603 1823 1294 2443 1666 1410 M13778 GO_ADRENAL_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENAL_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. 17/28 Gene Ontology BP GO:0030325 6.54860724433947e-07 1.08207080423379e-06 1045 1582.09090909091 1667 5.95328108511336e-08 234 2.3763814601593 3.00725378719373 1 17.0425282701469 1043 2162 1667 1920 2772 1628 2094 899 234 2183 801 1411 M15761 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 184/249 Gene Ontology BP GO:0007163 4.76216726798788e-08 4.02645553947883e-07 1785 1683.45454545455 1667 4.32924306460981e-09 213 1.87980181818167 2.20649686667979 1 14.4357851910606 1781 1698 1549 1125 213 1681 3590 2900 810 1667 1504 1412 M11212 GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. 45/66 Gene Ontology BP GO:0045806 4.08502562339355e-07 7.70475242223356e-07 1455 1712.72727272727 1668 3.71366034719407e-08 511 1.546190681938 -1.33623918027613 -1 11.328552206061 1453 511 3016 1029 2417 1084 1824 2253 1668 2544 1041 1413 M14313 GO_ACIDIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSPORT.html The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/26 Gene Ontology BP GO:0015800 4.76940927552196e-07 8.55845019629915e-07 1395 2051.45454545455 1670 4.33582755408078e-08 662 1.97958816113669 1.75304453423964 1 14.4235475732717 1395 1088 2294 3668 2544 1502 1670 3627 662 3134 982 1414 M11822 GO_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_PROLIFERATION.html The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 69/97 Gene Ontology BP GO:0072089 5.41132327711591e-07 9.38110551729521e-07 1420 1693.81818181818 1671 4.91938600739585e-08 130 2.11853424394208 2.62538379831535 1 15.3410296541564 1418 2453 1671 2709 2637 1035 2571 316 1300 2392 130 1415 M10159 GO_NEURONAL_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_DIVISION.html The self-renewing division of a neuronal stem cell. 16/21 Gene Ontology BP GO:0036445 8.59226815683953e-05 9.2460276905121e-05 1665 2429.18181818182 1672 7.81145795708161e-06 966 1.58855132291577 1.91299322055289 1 7.64720773159916 1662 3570 2998 3957 4298 1180 1672 1211 1629 3578 966 1416 M14924 GO_NEUROBLAST_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_DIVISION.html The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. 16/21 Gene Ontology BP GO:0055057 8.59226815683953e-05 9.2460276905121e-05 1665 2438.36363636364 1673 7.81145795708161e-06 967 1.58855132291577 1.91299322055289 1 7.64720773159916 1663 3571 2999 3958 4299 1181 1673 1294 1630 3587 967 1417 M15980 GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. 61/73 Gene Ontology BP GO:0051057 1.30275162252234e-06 1.85324203731873e-06 565 1790.09090909091 1675 1.1843203581456e-07 428 2.58004567210487 2.85166158938673 1 17.7828157032408 562 2460 428 1422 3237 1675 3816 1972 2064 738 1317 1418 M12783 GO_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIOGENESIS.html The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. 187/263 Gene Ontology BP GO:0042063 1.02144070753634e-08 1.69741557577379e-07 2360 1533.81818181818 1676 9.28582465708001e-10 198 2.37202820265546 2.6354479594049 1 19.3189154111426 2357 1676 198 523 518 1903 4129 2038 1257 365 1908 1419 M14320 GO_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 29/38 Gene Ontology BP GO:0070741 1.76246968998957e-07 4.67014320473887e-07 455 1947.63636363636 1676 1.60224530107728e-08 247 1.60508697058007 -1.71850966610844 -1 12.1860619203907 452 3253 3182 2791 1676 570 247 724 3852 3141 1536 1420 M14222 GO_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 312/453 Gene Ontology BP GO:0006066 2.03910685852708e-07 4.99381053281994e-07 1055 1748.09090909091 1677 1.85373367956831e-08 1038 2.01494780271344 -2.05214838360989 -1 15.2531599248405 1054 2775 1565 1909 1824 1038 1677 1087 2601 2075 1624 1421 M15054 GO_PARAXIAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARAXIAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. 17/23 Gene Ontology BP GO:0048339 1.82083537481867e-07 4.74907342995027e-07 3165 1801.27272727273 1678 1.65530502320052e-08 650 1.71747062449126 -1.37760591523853 -1 13.0313857616463 3162 1010 2355 1189 1703 2586 1340 1127 650 3014 1678 1422 M11684 GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html A process in which a protein is transported to, or maintained in, the cell periphery. 183/212 Gene Ontology BP GO:1990778 4.44438614796285e-08 4.02645553947883e-07 3785 1914.27272727273 1679 4.04035112522479e-09 175 2.10307268848476 -1.75943622315181 -1 16.1626043531503 3781 1679 843 393 175 3622 2975 3006 426 1091 3066 1423 M14719 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. 18/27 Gene Ontology BP GO:2000136 3.55524948773391e-07 6.991790307027e-07 1235 1635.63636363636 1680 3.23204551115486e-08 344 1.70047531016379 -1.38864898853286 -1 12.5559559090932 1232 2174 2481 1680 2310 1205 344 485 2950 2340 791 1424 M14743 GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. 78/129 Gene Ontology BP GO:0002702 2.95102935643669e-06 3.81951031863697e-06 190 1691.63636363636 1680 2.68275755898815e-07 190 1.73811996517351 -1.73826637171464 -1 11.2860828351862 190 1855 2034 2506 3570 357 640 1417 3533 1680 826 1425 M10052 GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 12/19 Gene Ontology BP GO:0071402 1.32340121424213e-06 1.87966601033841e-06 1235 1895.18181818182 1681 1.2030927366632e-07 161 2.60990437473641 2.65417486318411 1 17.9703992707268 1235 2714 1710 2967 3245 1210 906 161 3425 1593 1681 1426 M11220 GO_THYMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMUS_DEVELOPMENT.html The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. 57/80 Gene Ontology BP GO:0048538 1.76117552858903e-07 4.66937306810527e-07 1380 1958.45454545455 1683 1.60106879052472e-08 928 1.7106567365475 2.07700817686873 1 12.9944833962019 1379 3199 2754 1683 1675 1472 2195 1793 928 2941 1524 1427 M14403 GO_POTASSIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_IMPORT.html The directed movement of potassium ions into a cell or organelle. 19/35 Gene Ontology BP GO:0010107 3.51940321432969e-07 6.95537638350604e-07 1805 1594.72727272727 1683 3.19945797939896e-08 464 2.5124440470365 2.08957205809227 1 18.6074166662693 1804 961 712 2188 2297 854 1173 2050 3356 464 1683 1428 M15546 GO_ACTIN_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 193/243 Gene Ontology BP GO:0007015 9.11044549623731e-08 4.02645553947883e-07 4465 2664.09090909091 1684 8.2822235213737e-09 895 1.91346321438405 -1.66984580691447 -1 14.6961287992799 4464 1684 1665 1481 895 4379 3447 4422 1276 996 4596 1429 M12913 GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 37/48 Gene Ontology BP GO:0070169 7.41457569331715e-08 4.02645553947883e-07 2775 1718.63636363636 1686 6.74052358473431e-09 253 2.97043276998989 2.94099607581424 1 22.8709313603479 2775 574 591 506 634 2974 4445 1751 253 1686 2716 1430 M16857 GO_REGULATION_OF_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. 663/834 Gene Ontology BP GO:0022604 1.68062529665693e-10 4.05178730846875e-09 1690 1794.90909090909 1686 1.68062529678403e-11 111 2.17236727697991 2.41831879264363 1 21.9458962964743 1686 1396 4649 332 704 1776 3579 2100 1233 111 2178 1431 M10111 GO_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSPORT.html The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 894/1474 Gene Ontology BP GO:0006811 1.00992617290646e-16 6.35025200342398e-15 2335 1839.09090909091 1687 1.00992617290646e-17 46 2.23773789378167 -2.14200042712017 -1 38.319151490289 2335 1355 4225 1687 488 2109 2193 1636 1484 46 2672 1432 M16307 GO_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS.html An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. 190/443 Gene Ontology BP GO:0006909 4.27961545654274e-08 4.02645553947883e-07 3470 2030.45454545455 1687 3.89055958163021e-09 167 2.20429887616562 -1.97662132897619 -1 16.9455068444395 3467 1687 774 743 167 2794 1943 4566 1500 905 3789 1433 M10576 GO_HEART_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 34/39 Gene Ontology BP GO:0061384 2.47357898805721e-06 3.25332741323052e-06 1690 1812.27272727273 1688 2.2487106993093e-07 580 2.49723022288684 2.5891426247554 1 16.4706003241288 1688 2527 841 2198 3503 1719 3956 1129 1024 770 580 1434 M13200 GO_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of B cell differentiation. 27/36 Gene Ontology BP GO:0045577 1.07601467282422e-06 1.57945345084578e-06 1215 1825.63636363636 1688 9.78195635546137e-08 495 1.83155494312192 -1.88161358262308 -1 12.7478002299596 1212 849 2416 2456 3133 1688 1477 648 3465 2243 495 1435 M13209 GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that modulates the frequency, rate or extent of a response to nutrient levels. 202/261 Gene Ontology BP GO:0032107 9.13668800936319e-08 4.02645553947883e-07 900 1876.27272727273 1689 8.30608035346686e-09 34 1.38271001670691 -1.38940365007939 -1 10.5911831301691 900 2372 3913 2620 900 151 1393 1689 2478 4189 34 1436 M15881 GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 110/141 Gene Ontology BP GO:0007229 3.37614331719023e-07 6.78885086482941e-07 2190 1508.90909090909 1689 3.06922166845171e-08 67 2.38615372766936 2.56831565432229 1 17.6972937266753 1077 67 326 549 2258 2186 3586 2169 1689 503 2188 1437 M10076 GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that activates or increases the frequency, rate or extent of protein maturation. 21/42 Gene Ontology BP GO:1903319 8.99671117986804e-08 4.02645553947883e-07 4150 2354.81818181818 1690 8.17882867980076e-09 363 3.54116594360483 -3.23691483686205 -1 27.2850897290624 4150 915 690 726 883 3752 4526 3958 363 1690 4250 1438 M10985 GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. 21/23 Gene Ontology BP GO:2000050 1.68292021314189e-06 2.31743940566712e-06 1770 1690.81818181818 1691 1.52992863683291e-07 742 2.15432921607711 2.42342241548895 1 14.5786749043909 1770 2130 2040 2255 3348 1034 742 1579 955 1691 1055 1439 M11432 GO_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 47/50 Gene Ontology BP GO:0044088 1.80049571863208e-07 4.72066258868601e-07 815 1863.54545454545 1691 1.63681442362359e-08 99 1.10574265746035 -1.02422806318069 -1 8.35668563485695 811 1938 3705 2798 1691 194 506 1596 2872 4289 99 1440 M14441 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION.html The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. 23/26 Gene Ontology BP GO:0015949 3.50412312553172e-07 6.9529573147544e-07 1525 1868.81818181818 1691 3.1855669851479e-08 579 1.49116177108781 1.94763452059995 1 11.0021172232633 1521 847 2500 3652 2288 1691 1074 1418 579 3099 1888 1441 M10656 GO_SECRETION_BY_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION_BY_CELL.html The controlled release of a substance by a cell. 480/746 Gene Ontology BP GO:0032940 8.86839949990677e-08 4.02645553947883e-07 2415 1706.63636363636 1692 8.06218168854548e-09 296 2.11218596196095 -2.02959614951247 -1 16.233088134786 2413 1465 296 1468 864 1789 1692 3097 2899 596 2194 1442 M14504 GO_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 468/671 Gene Ontology BP GO:0008610 1.80053508120927e-07 4.72066258868601e-07 885 1857 1692 1.63685020779053e-08 857 1.78871151404192 -1.77301597928239 -1 13.5818372235395 884 2335 2498 2833 1692 857 1414 1409 2567 2560 1378 1443 M10676 GO_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 31/35 Gene Ontology BP GO:0051125 2.506923713007e-07 5.61029310665405e-07 1460 1912 1693 2.2790218169761e-08 1010 1.75193690828884 -1.96123520248471 -1 13.1416156040873 1459 2011 2800 1615 2018 1647 1693 1957 1275 3547 1010 1444 M12216 GO_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_DEVELOPMENT.html The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 90/114 Gene Ontology BP GO:0001892 1.01276766527376e-07 4.02645553947883e-07 2775 1809.36363636364 1694 9.20697919905836e-09 190 2.01085397051197 -2.41954485622922 -1 15.4493673371321 2771 190 2031 1169 1025 3009 3040 1694 1249 2394 1331 1445 M13394 GO_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 100/158 Gene Ontology BP GO:0006865 1.12720913449758e-07 4.05064193023647e-07 4140 1996.27272727273 1694 1.02473562932013e-08 86 2.22302837970213 -2.00083150246514 -1 17.083371661597 4139 86 491 1694 1177 2684 2249 4164 559 687 4029 1446 M13818 GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. 20/21 Gene Ontology BP GO:0031293 1.80363526267562e-07 4.72066258868601e-07 320 1990.54545454545 1694 1.63966855503984e-08 147 1.43281374343644 -1.16820232638572 -1 10.8589900782162 320 2990 3280 4166 1694 329 147 1278 3590 3675 427 1447 M11745 GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. 22/25 Gene Ontology BP GO:0044818 5.68474467966764e-07 9.76416278866502e-07 1440 2196.90909090909 1695 5.16795104417445e-08 1120 1.70194497331663 2.05146968996621 1 12.2683431062733 1439 3767 3306 2569 2666 1617 1268 1120 1695 3266 1453 1448 M12290 GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY.html Any process that modulates the activity of the enzyme lipoprotein lipase. 7/17 Gene Ontology BP GO:0051004 8.23410310655068e-07 1.285680595798e-06 1695 1678.09090909091 1695 8.23410615757268e-08 135 1.73638937891252 -2.01098714393445 -1 12.2677725804394 1695 2303 4361 1950 3002 1375 555 355 135 2527 201 1449 M15667 GO_MECHANOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of a mechanical stimulus. 13/22 Gene Ontology BP GO:0007638 6.7680198097315e-08 4.02645553947883e-07 1915 1672.81818181818 1695 6.15274547085546e-09 527 1.98574447792118 2.09427685014856 1 15.2551657697836 1914 1140 1695 2896 527 1025 899 1723 3348 1820 1414 1450 M15987 GO_O_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_GLYCAN_PROCESSING.html The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. 40/65 Gene Ontology BP GO:0016266 4.97454628552721e-07 8.83456636128173e-07 3025 1805.45454545455 1695 4.52231582759163e-08 558 2.85045277439036 -2.83044855589089 -1 20.7665395006946 3023 562 558 1695 2574 2752 1292 1259 1981 753 3411 1451 M11625 GO_REGULATION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSITIVE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 29/34 Gene Ontology BP GO:0050926 1.34402735939313e-07 4.22265989416356e-07 2330 1839.81818181818 1696 1.22184312863878e-08 965 2.50180558898394 2.68810176140548 1 19.1839599047268 1669 2572 965 1803 1379 1696 1561 2329 2329 1533 2402 1452 M16674 GO_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_ASSEMBLY.html The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 21/22 Gene Ontology BP GO:0046847 5.7153120303522e-08 4.02645553947883e-07 3205 1813.63636363636 1696 5.19573834438957e-09 119 2.2858539046103 -2.21456928059934 -1 17.57626886768 3204 871 1248 119 358 3617 3274 2005 320 1696 3238 1453 M12875 GO_ENDOCRINE_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. 28/51 Gene Ontology BP GO:0031018 7.60088775066022e-07 1.206239109953e-06 1685 1753.81818181818 1697 6.90990034248129e-08 205 2.05208030994962 -2.43230964857404 -1 14.5856252000612 1681 806 2336 205 2888 2584 1636 2401 342 2716 1697 1454 M10476 GO_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of a cytokine. 547/853 Gene Ontology BP GO:0001817 1.29148007204403e-08 2.08654749139614e-07 1270 1905.18181818182 1698 1.29148007954968e-09 158 2.02689651956319 -2.05886100966413 -1 16.2732830849836 1266 1431 4243 1893 1266 1698 1684 2158 3087 158 2073 1455 M13299 GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. 17/26 Gene Ontology BP GO:0006688 1.99252958586116e-07 4.93878508235586e-07 4020 2054.27272727273 1698 1.81139069665786e-08 242 2.72505354817389 -2.64650406460556 -1 20.6808050343673 4020 1014 1106 1698 1798 4026 3710 3489 902 592 242 1456 M16329 GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 370/682 Gene Ontology BP GO:0098660 2.79616419969404e-12 9.22734185899034e-11 4500 2382.09090909091 1699 2.54196745427054e-13 91 2.32911762953173 2.53612007720427 1 28.1637021089216 4500 1513 91 1236 656 4021 4366 3451 1699 222 4448 1457 M10120 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. 115/144 Gene Ontology BP GO:0031333 1.81182685828649e-07 4.72822791453003e-07 3190 1714.27272727273 1701 1.64711546136446e-08 68 2.27813670377833 -2.36194234593496 -1 17.3243390536265 3187 68 1641 167 1701 2959 2947 2470 415 2974 328 1458 M13178 GO_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that modulates the frequency, rate or extent of response to wounding. 411/603 Gene Ontology BP GO:1903034 7.20567615010653e-16 4.0887818446885e-14 1705 1711.09090909091 1701 6.550614681915e-17 45 2.38102480634528 -2.29458396329032 -1 38.450364199832 1701 1501 45 1469 405 2323 1829 3358 3252 124 2815 1459 M13446 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. 194/275 Gene Ontology BP GO:2000377 1.27218458433094e-07 4.17034908558357e-07 2875 1939.45454545455 1701 1.15653150717911e-08 815 2.12354127246391 -2.15271282383747 -1 16.2817484055347 2873 1701 835 815 1311 3403 3242 2606 2333 1121 1094 1460 M13257 GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of receptor activity. 49/62 Gene Ontology BP GO:2000273 1.92033438822809e-07 4.89360752707036e-07 835 1653.63636363636 1702 1.74575868713647e-08 586 2.12353582869786 2.58913674963443 1 16.1033277380085 834 2491 1914 2736 1744 599 1532 586 3420 1702 632 1461 M14655 GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. 15/19 Gene Ontology BP GO:0006646 7.34891212253046e-08 4.02645553947883e-07 880 1653.09090909091 1704 6.68082942546783e-09 304 1.83729304746219 -1.74822763921999 -1 14.1070143140732 876 3031 2323 3858 623 764 304 1704 1895 2234 572 1462 M10703 GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS.html The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 182/306 Gene Ontology BP GO:0050954 4.80682491251744e-15 2.2653483719148e-13 3975 2142.45454545455 1705 4.3698408295613e-16 14 2.74069083244852 2.96497076889338 1 41.8095120480423 3972 1670 59 14 1705 4639 2806 3904 542 230 4026 1463 M14639 GO_HEART_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_DEVELOPMENT.html The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. 39/47 Gene Ontology BP GO:0003170 2.82006886557726e-07 5.98348400890605e-07 2630 1679 1706 2.56369929733428e-08 211 2.70428764134029 3.0457831372496 1 20.2498764167298 2626 509 331 515 2344 2393 4650 2238 946 211 1706 1464 M11040 GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. 26/31 Gene Ontology BP GO:0045606 2.34658640754826e-06 3.10453982209897e-06 1710 1794.27272727273 1707 2.13326264590172e-07 546 1.92028454370469 -1.6082584001764 -1 12.6887563455306 1707 2064 2327 2732 3482 994 903 952 1592 2438 546 1465 M15775 GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 116/203 Gene Ontology BP GO:0043271 1.01991116683265e-07 4.02645553947883e-07 2400 1854 1708 9.2719201283211e-09 40 2.08986171642212 2.06056992602387 1 16.0604281952098 2400 40 976 1128 1038 1708 3391 3609 2864 775 2465 1466 M10449 GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any negative regulation of signal transduction that takes place in extracellular region. 9/15 Gene Ontology BP GO:1900116 3.39014293278354e-07 6.80221434508057e-07 1730 1947.54545454545 1709 3.39014344997177e-08 1080 2.34785716259033 2.60827315766126 1 17.4091836053843 1726 1231 4241 3139 2353 1709 1195 1080 1589 1900 1260 1467 M13078 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of multicellular organismal development. 1657/2329 Gene Ontology BP GO:2000026 9.3559950907221e-28 5.42756767634918e-25 1930 1704.36363636364 1709 9.35599509072216e-29 7 2.2071156910063 2.40048607822179 1 64.6681714726127 1929 1299 4405 285 503 1413 3545 1811 1842 7 1709 1468 M16443 GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. 42/48 Gene Ontology BP GO:0035924 2.72301237460135e-07 5.84148297787924e-07 1645 1723 1709 2.47546610148873e-08 551 1.8061187280218 1.84161917608925 1 13.5129204402444 1641 551 2221 1218 2109 783 1022 1910 3033 1709 2756 1469 M13296 GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any regulation of signal transduction that takes place in the extracellular region. 9/15 Gene Ontology BP GO:1900115 3.39014293278354e-07 6.80221434508057e-07 1730 1970 1710 3.39014344997177e-08 1139 2.34785716259033 2.60827315766126 1 17.4091836053843 1727 1232 4419 3140 2354 1710 1196 1139 1590 1902 1261 1470 M12119 GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 139/217 Gene Ontology BP GO:0046890 1.2457371005518e-07 4.14338946095474e-07 1035 1722.36363636364 1711 1.13248833735539e-08 633 1.93200695239277 -1.64203169992126 -1 14.8104994296367 1032 1814 1882 2518 1286 633 650 3473 2607 1711 1340 1471 M12590 GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. 11/18 Gene Ontology BP GO:0002830 1.61794770420315e-06 2.23790447908956e-06 930 1722.09090909091 1711 1.47086263099356e-07 929 2.76041800336834 -2.91009618755881 -1 18.7597696002635 929 1238 1806 1199 3333 1701 1902 1474 1790 1860 1711 1472 M11955 GO_REPLACEMENT_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLACEMENT_OSSIFICATION.html Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. 42/52 Gene Ontology BP GO:0036075 5.0732347493295e-06 6.29990960465176e-06 1430 1994.27272727273 1712 4.61204222575158e-07 643 2.41438131082738 2.5997870545966 1 15.0827069244387 643 1942 856 1429 3722 1430 2764 3490 2494 1455 1712 1473 M16887 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. 281/394 Gene Ontology BP GO:0032102 4.34260377023589e-15 2.10480576488621e-13 3285 1925.54545454545 1712 3.94782160930534e-16 57 2.40469722482866 2.61835208244716 1 36.7641134793374 3284 1563 57 390 701 2910 4620 1712 2514 77 3353 1474 M12956 GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of muscle cell differentiation. 178/264 Gene Ontology BP GO:0051147 5.73964397366475e-08 4.02645553947883e-07 3855 2273.27272727273 1713 5.21785829400725e-09 364 2.15269067401011 2.14384042853629 1 16.5463592427745 3855 1713 769 1361 364 3983 4243 2307 1056 991 4364 1475 M15454 GO_ENDOCHONDRAL_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_OSSIFICATION.html Replacement ossification wherein bone tissue replaces cartilage. 42/52 Gene Ontology BP GO:0001958 5.0732347493295e-06 6.29990960465176e-06 645 1996.09090909091 1713 4.61204222575158e-07 644 2.41438131082738 2.5997870545966 1 15.0827069244387 644 1943 857 1430 3723 1431 2765 3499 2495 1457 1713 1476 M15992 GO_NEUTRAL_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSPORT.html The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 25/38 Gene Ontology BP GO:0015804 5.78853862070935e-08 4.02645553947883e-07 4515 2102.90909090909 1713 5.26230797546793e-09 374 2.62303464484959 2.2454161453193 1 20.1840885198469 4514 858 1208 1713 374 4047 3215 2074 772 1635 2722 1477 M13215 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). 418/1835 Gene Ontology BP GO:0007186 7.08341520394914e-26 2.19727539626502e-23 2355 1695.72727272727 1715 6.43946836722648e-27 7 2.51964698148934 2.71172680602655 1 68.9420835210838 2353 1472 7 1039 462 1715 4569 3019 2042 24 1951 1478 M14802 GO_ACETYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. 11/12 Gene Ontology BP GO:0006085 1.92569909840528e-06 2.60852340753414e-06 3405 2238.18181818182 1715 1.75063707636908e-07 280 1.82744505481669 -1.82744505481669 -1 12.2374083471387 1333 4100 3404 3241 3404 1577 709 825 280 4032 1715 1479 M10509 GO_RESPONSE_TO_ESTRADIOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTRADIOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 171/226 Gene Ontology BP GO:0032355 1.31350986538735e-07 4.19475731204347e-07 1775 1714.72727272727 1716 1.19409994891859e-08 229 2.26449469824376 2.3087734497978 1 17.3623683343077 1773 1716 340 229 1354 1446 2872 3628 2431 717 2356 1480 M16269 GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 799/1010 Gene Ontology BP GO:0051129 8.12504490155646e-08 4.02645553947883e-07 2010 1839.81818181818 1716 8.12504519863005e-09 870 1.89563977575414 2.0287873968447 1 14.5582789520577 2006 1380 4611 1056 870 1133 2097 2290 1716 927 2152 1481 M14602 GO_DETECTION_OF_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_STIMULUS.html The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. 235/1291 Gene Ontology BP GO:0051606 1.00643052743379e-07 4.02645553947883e-07 2690 1718.18181818182 1717 9.14936884977100e-09 239 2.18012287547867 2.35098464881454 1 16.7585250801268 2686 1617 297 1717 1015 2319 4546 1778 1855 239 831 1482 M14860 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. 47/61 Gene Ontology BP GO:0030857 2.31049509302216e-07 5.33270519237704e-07 2415 1795.90909090909 1719 2.10045030516016e-08 490 2.34044354719372 -1.96111536207912 -1 17.6530814752372 2414 490 1051 1190 1953 2388 2307 3830 1305 1108 1719 1483 M12656 GO_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 668/1075 Gene Ontology BP GO:0051046 2.53270809687951e-16 1.47308634684755e-14 2040 1701.27272727273 1721 2.53270809687951e-17 15 2.22455205502789 -2.17452391053626 -1 37.1095893296653 2038 1395 4381 15 517 1721 2010 2350 1707 50 2530 1484 M11204 GO_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_PROLIFERATION.html The expansion of a B cell population by cell division. Follows B cell activation. 19/53 Gene Ontology BP GO:0042100 2.36566065798943e-07 5.40905112610556e-07 2825 1895.63636363636 1723 2.15060082942639e-08 703 2.52660037093059 -2.40114764452595 -1 19.0465170667145 2823 964 1259 808 1972 2320 703 4254 2324 1723 1702 1485 M11324 GO_PITUITARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PITUITARY_GLAND_DEVELOPMENT.html The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. 29/63 Gene Ontology BP GO:0021983 2.12742604919835e-07 5.1104354191636e-07 2770 1787.36363636364 1723 1.93402386811181e-08 781 2.59509611900889 2.65211082677693 1 19.6430618442261 2769 781 918 1195 1865 1723 1045 2764 2669 855 3077 1486 M15679 GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 177/308 Gene Ontology BP GO:0006140 6.19117174582229e-08 4.02645553947883e-07 1850 1761.54545454545 1723 5.62833810913847e-09 434 2.10768847790783 2.22479833310531 1 16.1983037420276 1848 1723 1124 782 434 574 2858 4486 2960 811 1777 1487 M13839 GO_SIGNAL_RELEASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_RELEASE.html The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. 163/246 Gene Ontology BP GO:0023061 1.62924629120546e-07 4.49256982271346e-07 2215 1761.45454545455 1724 1.48113310169272e-08 503 2.10067342746686 -2.10739672199102 -1 16.0231892079209 2215 1724 503 1047 1600 1188 1756 4277 2039 569 2458 1488 M14456 GO_MONOCARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSPORT.html The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 112/209 Gene Ontology BP GO:0015718 2.8978148918477e-08 3.72894192114222e-07 2810 1596.36363636364 1724 2.63437720910672e-09 36 2.48987083439355 -2.2992379868869 -1 19.2545610931713 2809 36 220 674 84 2997 1790 3616 1724 392 3218 1489 M14997 GO_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_RESORPTION.html Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). 33/43 Gene Ontology BP GO:0045124 3.30237094009939e-07 6.67503561437118e-07 1725 1843.81818181818 1724 3.0021558507373e-08 642 3.54697280070454 -4.59459402742556 -1 26.3882804205966 1724 2906 642 1058 2246 2851 1513 1168 2860 1246 2068 1490 M16017 GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/55 Gene Ontology BP GO:0032892 1.02202386029498e-07 4.02645553947883e-07 2370 2024.36363636364 1724 9.2911264343067e-09 734 2.51899092628785 2.83948644730001 1 19.3793947115432 2367 734 895 1724 1039 3280 4617 1804 3355 1535 918 1491 M12445 GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH.html Any process that controls the length of actin filaments in a cell. 167/207 Gene Ontology BP GO:0030832 8.16608341269662e-08 4.02645553947883e-07 3335 2342.09090909091 1725 7.42371246891811e-09 765 1.96709373270979 -1.74328351857918 -1 15.110917376903 3333 1725 1664 1315 765 3450 2999 4146 967 1704 3695 1492 M13613 GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. 19/24 Gene Ontology BP GO:0070884 2.53234717872836e-07 5.64050331384541e-07 2445 1858.63636363636 1725 2.30213406383501e-08 388 2.27371123576084 -2.31661028251609 -1 17.0797953578077 2445 953 1515 1154 2029 2413 2620 4258 388 1725 945 1493 M10825 GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. 17/22 Gene Ontology BP GO:0034114 4.69113605681069e-05 5.15537460376479e-05 1470 2224.72727272727 1726 4.26476008228445e-06 1395 2.99219666230506 -2.80023881119107 -1 15.4133206118614 1467 3561 1469 3216 4206 2371 1478 1395 1405 2178 1726 1494 M12132 GO_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGING.html A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). 324/435 Gene Ontology BP GO:0007568 1.02573386875633e-07 4.02645553947883e-07 3000 1960 1726 9.3248537870947e-09 409 2.22294574358696 2.41139804186838 1 17.0897252457581 2997 1555 409 576 1043 3160 4553 2087 1726 825 2629 1495 M13295 GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 45/69 Gene Ontology BP GO:0060393 6.84262298739774e-07 1.11071488399247e-06 1485 2042.27272727273 1726 6.22056828695288e-08 901 2.00849305013705 1.9850959135995 1 14.3606674267645 1485 1926 1375 1726 2821 901 1207 4493 3456 1305 1770 1496 M12933 GO_ONE_CARBON_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_COMPOUND_TRANSPORT.html The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/11 Gene Ontology BP GO:0019755 1.70848012465849e-07 4.59245216956312e-07 2290 2200.72727272727 1727 1.70848025600919e-08 1250 4.85739466779466 -4.72771900550699 -1 37.1294889818439 2289 1261 4395 1705 1727 2610 2381 1250 3421 1583 1586 1497 M15406 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 1207/1669 Gene Ontology BP GO:0051094 2.09124680639058e-25 5.40587299451965e-23 2120 1823.09090909091 1728 2.09124680639059e-26 10 2.25672919785405 2.43282371522486 1 60.6703371972547 2118 1322 4553 294 345 1595 3483 2276 1728 10 2330 1498 M13498 GO_CELLULAR_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. 14/21 Gene Ontology BP GO:0006883 2.1659794513727e-07 5.13962042198191e-07 3465 1920.18181818182 1729 1.96907242238293e-08 550 2.62376310781966 2.05925132571605 1 19.853340520885 3462 1053 996 1729 1888 2891 3090 918 550 1208 3337 1499 M15713 GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-2 production. 50/66 Gene Ontology BP GO:0032663 1.2939558113917e-07 4.18690986815408e-07 3370 2341.63636363636 1729 1.17632353408839e-08 416 1.8351781092498 -1.85395597772972 -1 14.052991191082 3366 416 1729 1136 1331 4109 3877 3382 1623 861 3928 1500 M14131 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. 18/23 Gene Ontology BP GO:1903019 9.87359304482945e-07 1.47815807653987e-06 855 1857.27272727273 1730 8.97599770554335e-08 374 1.90544535813571 -1.53519793073937 -1 13.3325738299741 1435 2650 2768 2458 3070 1473 374 855 1730 2764 853 1501 M16715 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 19/21 Gene Ontology BP GO:0010664 4.10275913633602e-07 7.73193125207433e-07 3060 1969.54545454545 1730 3.72978172859625e-08 727 2.25315080425478 2.62617582012703 1 16.5511799354545 3057 960 1609 3180 2419 2637 2826 1170 727 1730 1350 1502 M16970 GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of stem cell differentiation. 162/226 Gene Ontology BP GO:2000736 9.99029924295662e-08 4.02645553947883e-07 2830 1835.36363636364 1731 9.08209063329152e-09 442 2.05506485153638 2.26923715508355 1 15.7913026573205 2828 1731 630 612 1002 3046 4074 2309 1303 442 2212 1503 M10062 GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 35/50 Gene Ontology BP GO:0050856 5.33870172208093e-08 4.02645553947883e-07 2425 1595.81818181818 1732 4.85336531966751e-09 113 2.41115736214349 -2.59665870599142 -1 18.5453895203234 2424 630 1250 476 298 2671 1922 2173 113 1732 3865 1504 M12474 GO_REGULATION_OF_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_PLASTICITY.html A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 166/229 Gene Ontology BP GO:0048167 4.53806341524132e-08 4.02645553947883e-07 2845 1888.36363636364 1732 4.12551228077319e-09 183 2.23313172464288 2.69329472021264 1 17.1685055508116 2845 1732 561 1363 183 2464 3821 3056 1653 704 2390 1505 M16739 GO_METANEPHROS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_MORPHOGENESIS.html The process in which the anatomical structures of the metanephros are generated and organized. 21/38 Gene Ontology BP GO:0003338 3.14803295555784e-07 6.45277415956415e-07 2200 1617.09090909091 1733 2.86184855092503e-08 193 2.0914801904236 2.28561093966646 1 15.5548588087013 2197 851 1000 193 2210 1733 2996 2589 1715 359 1945 1506 M11056 GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION.html The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. 10/18 Gene Ontology BP GO:0048505 3.45629176106287e-07 6.88152570142299e-07 3395 1923.45454545455 1734 3.14208391278258e-08 255 2.15312497333765 -1.95972237120004 -1 15.9436102077337 3393 1214 1734 255 2278 3074 1201 3156 395 1612 2846 1507 M10851 GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a sphingolipid. 11/14 Gene Ontology BP GO:0090520 1.90034338597385e-07 4.86483466842119e-07 3065 1648.45454545455 1735 1.72758504556736e-08 335 2.92478202240361 -3.39568237435033 -1 22.227293979212 3065 2259 1382 434 1735 3660 2129 348 335 1856 930 1508 M12350 GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. 41/72 Gene Ontology BP GO:0001754 6.23995816865023e-07 1.04365655495074e-06 3465 1965.09090909091 1735 5.67269085319829e-08 137 2.73716651978344 3.3986691404823 1 19.697542036102 3464 1953 629 1735 2740 3492 4542 137 952 817 1155 1509 M14964 GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC.html Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. 10/18 Gene Ontology BP GO:0040034 3.45629176106287e-07 6.88152570142299e-07 3395 1923.72727272727 1735 3.14208391278258e-08 256 2.15312497333765 -1.95972237120004 -1 15.9436102077337 3394 1215 1735 256 2279 3075 1202 3142 396 1620 2847 1510 M15386 GO_CEREBELLAR_CORTEX_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_FORMATION.html The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 28/45 Gene Ontology BP GO:0021697 1.3791308740065e-07 4.24835370983751e-07 3620 2100.72727272727 1735 1.25375541860104e-08 176 2.52386369939791 -2.12375873760184 -1 19.3459686482586 3618 2043 1251 176 1406 3530 1899 1735 1595 1412 4443 1511 M10221 GO_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 155/226 Gene Ontology BP GO:0045471 1.42511366455991e-09 2.89565671668003e-08 3980 2075.27272727273 1736 1.29555787771189e-10 160 2.48557269810891 2.70322399712141 1 22.5573698256982 3978 1736 160 382 594 3745 4297 2716 1199 440 3581 1512 M11533 GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. 22/36 Gene Ontology BP GO:1903306 6.04308588624279e-07 1.01886743302043e-06 995 1608.27272727273 1736 5.49371595108439e-08 273 1.96113447597169 -1.91500307456787 -1 14.1085336957637 992 2111 2432 2097 2717 1736 273 399 311 3264 1359 1513 M15471 GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 11/14 Gene Ontology BP GO:0003376 1.90034338597385e-07 4.86483466842119e-07 3070 1646.36363636364 1736 1.72758504556736e-08 301 2.92478202240361 -3.39568237435033 -1 22.227293979212 3066 2260 1383 435 1736 3661 2130 301 336 1871 931 1514 M11049 GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. 147/173 Gene Ontology BP GO:0045931 1.32286394128333e-07 4.20399283289481e-07 2565 1717.81818181818 1737 1.20260365529762e-08 803 1.80367152976997 1.98083048368167 1 13.8061025833168 803 1787 2562 2077 1359 1212 832 2562 2751 1737 1214 1515 M14458 GO_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DIFFERENTIATION.html The establishment of the sex of an organism by physical differentiation. 281/438 Gene Ontology BP GO:0007548 2.62861976073545e-07 5.72075198629656e-07 915 1817.09090909091 1737 2.38965461346376e-08 911 2.11155306669053 2.10193781552893 1 15.8386757834621 1737 1592 914 1765 2077 911 2067 3689 2156 1395 1685 1516 M14574 GO_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT.html The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 158/290 Gene Ontology BP GO:0045165 5.67343224207209e-08 4.02645553947883e-07 3755 1830.27272727273 1737 5.15766580761858e-09 139 2.40526866263687 2.73075524793378 1 18.499845203978 3753 1737 322 139 352 3375 4399 1909 743 461 2943 1517 M15988 GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 77/141 Gene Ontology BP GO:0030801 6.53940495054086e-08 4.02645553947883e-07 1900 1893 1737 5.94491376811077e-09 246 2.21012886473455 2.41096569772542 1 16.9905970792826 1897 246 1130 1986 491 1327 3476 4298 3366 869 1737 1518 M10262 GO_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 176/205 Gene Ontology BP GO:0010212 1.91139529977826e-07 4.88666062080673e-07 1635 1863.54545454545 1738 1.73763224167579e-08 980 1.87059699272266 2.1363200579216 1 14.1743585906196 1635 2802 2609 2744 1738 980 1128 1184 2300 2305 1074 1519 M11550 GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. 5/15 Gene Ontology BP GO:0021521 3.7136526626988e-05 4.11223841969003e-05 1740 2048.09090909091 1738 3.71371472463093e-06 151 1.59496098507023 1.67178444778042 1 8.35722894336204 1738 2312 4310 1671 4185 1069 151 919 3468 1894 812 1520 M15600 GO_LOCALIZATION_WITHIN_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_WITHIN_MEMBRANE.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. 164/194 Gene Ontology BP GO:0051668 1.14701049103807e-07 4.07598035460087e-07 2025 1947.27272727273 1738 1.04273686439961e-08 946 2.17140837608954 2.58091258639959 1 16.6771830941806 2024 1738 987 946 1191 2829 4115 2774 1225 1118 2473 1521 M15014 GO_CONNECTIVE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNECTIVE_TISSUE_DEVELOPMENT.html The progression of a connective tissue over time, from its formation to the mature structure. 206/273 Gene Ontology BP GO:0061448 1.09081165896766e-08 1.79983923729664e-07 950 1574.54545454545 1739 9.91646967614689e-10 199 2.33880930652532 2.54443428538759 1 18.9749492484412 948 2366 199 1739 2349 682 2274 2437 3119 208 999 1522 M15625 GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION.html The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. 5/15 Gene Ontology BP GO:0060573 3.7136526626988e-05 4.11223841969003e-05 1740 2072.90909090909 1739 3.71371472463093e-06 152 1.59496098507023 1.67178444778042 1 8.35722894336204 1739 2313 4565 1672 4186 1070 152 927 3469 1896 813 1523 M11511 GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 47/83 Gene Ontology BP GO:0048260 6.08348406631269e-08 4.02645553947883e-07 4425 2347.81818181818 1740 5.53044021321309e-09 416 2.31959941954339 2.03810311190462 1 17.837263066081 4421 500 1343 536 416 3747 4484 1563 3449 1740 3627 1524 M15840 GO_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTION.html The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. 1178/2036 Gene Ontology BP GO:0000003 1.34061046135371e-07 4.21762033582069e-07 1475 1787.81818181818 1740 1.34061054222935e-08 210 2.05655746876327 2.08774946908596 1 15.7527433532924 1473 1332 4575 2163 1474 627 1740 2147 2107 210 1818 1525 M16971 GO_BRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). 33/55 Gene Ontology BP GO:0048854 1.08050951024002e-06 1.58362317603025e-06 2240 1789.72727272727 1741 9.82281855384155e-08 454 2.56354623877101 3.13058353205076 1 17.8801284320857 2240 732 1473 1848 3139 1741 2905 454 1570 2074 1511 1526 M12847 GO_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_VACUOLE.html A process in which a protein is transported to, or maintained at, a location in a vacuole. 59/61 Gene Ontology BP GO:0072665 1.91947229393496e-07 4.89360752707036e-07 330 2121.18181818182 1742 1.74497496491501e-08 26 1.12521231098809 -1.03508761379427 -1 8.48437647382406 330 3927 3982 4040 1742 49 77 537 4270 4353 26 1527 M15439 GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 13/19 Gene Ontology BP GO:0050746 4.48057787985673e-07 8.23385816547131e-07 2015 1772.45454545455 1742 4.07325344762115e-08 694 2.85713871143466 -2.20850966916287 -1 20.9211634035455 2012 2234 1742 1540 2482 1734 816 2586 868 2789 694 1528 M10368 GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. 69/129 Gene Ontology BP GO:0002821 9.35898313824728e-07 1.42079440594664e-06 370 1756.36363636364 1743 8.50817010876272e-08 366 1.51924430097879 -1.4986648647371 -1 10.6410059930795 366 1872 2906 2567 3028 603 796 1104 3362 1743 973 1529 M14103 GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 23/30 Gene Ontology BP GO:0018146 8.79386152348288e-08 4.02645553947883e-07 1745 1756.27272727273 1743 7.99441988635638e-09 502 2.46537477720334 2.66145678940891 1 18.9647172683509 1743 872 657 3649 858 2198 2181 1178 2942 502 2539 1530 M16310 GO_ALKALOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). 12/31 Gene Ontology BP GO:0009820 0.000855288030345039 0.000883386283062257 1270 2135.63636363636 1743 7.77837017672697e-05 157 2.85555627416451 -3.16801669783999 -1 10.4435175468976 1270 3824 2292 2955 4599 1335 157 1233 1508 2576 1743 1531 M10459 GO_POSITIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEMOPOIESIS.html Any process that activates or increases the frequency, rate or extent of hemopoiesis. 162/254 Gene Ontology BP GO:1903708 1.14842257573216e-07 4.07598035460087e-07 1315 1723.72727272727 1744 1.04402057789182e-08 595 2.00015165185026 -2.12764716683922 -1 15.3537508032619 1312 1744 1246 2439 1195 1851 2109 1063 3542 595 1865 1532 M10708 GO_EMBRYONIC_DIGIT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGIT_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. 74/89 Gene Ontology BP GO:0042733 1.16644807118106e-07 4.08548528935279e-07 2930 1914.81818181818 1744 1.06040739366052e-08 257 2.13067516620226 2.28940205191389 1 16.3597996404756 2929 278 1803 257 1213 1513 2435 4574 1549 1744 2768 1533 M11239 GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. 151/245 Gene Ontology BP GO:0022408 1.33218623092207e-07 4.20399283289481e-07 1780 1833.72727272727 1745 1.21107846508288e-08 557 2.12272149920655 -1.93178081898491 -1 16.266464803774 1776 1745 597 1103 1369 2283 2914 3846 1578 557 2403 1534 M14845 GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 57/107 Gene Ontology BP GO:0042108 6.03029010046292e-07 1.01773448811948e-06 1150 1847 1746 5.48208341217342e-08 678 2.40151630587814 -2.2468759512945 -1 17.3011933018197 1148 3198 1173 2288 2715 1746 1245 678 2798 1343 1985 1535 M16475 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. 62/90 Gene Ontology BP GO:1902305 1.17906666995964e-07 4.08807542125352e-07 3040 1770.72727272727 1746 1.07187884831861e-08 295 2.23947120676168 -1.92958241736012 -1 17.1996716521002 3038 295 850 1746 1224 2830 2167 1718 2467 794 2349 1536 M16688 GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. 113/187 Gene Ontology BP GO:0034111 1.91975596891914e-07 4.89360752707036e-07 2210 1951.09090909091 1747 1.74523285130928e-08 29 2.05894066374281 -1.96236482826696 -1 15.610353862342 2206 29 781 1747 1743 2636 3452 3592 1591 589 3096 1537 M10204 GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. 46/70 Gene Ontology BP GO:2000242 1.78353427713814e-07 4.70452663918581e-07 1750 2071.18181818182 1748 1.62139492884438e-08 531 2.19862284582725 1.99787743810069 1 16.7218769175081 1748 531 1541 2665 1683 1561 1873 4504 1302 2639 2736 1538 M11543 GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 23/32 Gene Ontology BP GO:0046131 2.766475585647e-07 5.90748549794195e-07 1505 2053.90909090909 1748 2.51497812138937e-08 634 1.3726287975549 1.60903782065581 1 10.2368477516073 1502 2597 3134 3447 2121 1748 979 634 883 3860 1688 1539 M13399 GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. 17/30 Gene Ontology BP GO:0033630 2.58195426097772e-07 5.67674433889539e-07 710 1637.45454545455 1748 2.34723142181813e-08 197 1.93358741438399 -1.96263394253075 -1 14.5029277522611 709 2644 2090 2749 2056 1520 819 197 2492 1748 988 1540 M14879 GO_CELLULAR_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 156/199 Gene Ontology BP GO:0097306 1.23261119487842e-07 4.14338946095474e-07 3505 2236.72727272727 1748 1.1205556944899e-08 135 2.42162938111012 2.43134194134829 1 18.5899698606064 3503 1748 257 135 1464 3263 4244 4289 1200 516 3985 1541 M15236 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI.html The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. 77/82 Gene Ontology BP GO:0042147 6.14039576400305e-08 4.02645553947883e-07 1270 2280.81818181818 1748 5.58217812307906e-09 426 1.02085010884299 -1.01904031669924 -1 7.79249012537556 1268 3189 4062 4011 426 1055 617 1169 3242 4302 1748 1542 M16080 GO_NEURONAL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ACTION_POTENTIAL.html An action potential that occurs in a neuron. 16/51 Gene Ontology BP GO:0019228 4.03889530038493e-08 4.02645553947883e-07 1970 1690.81818181818 1748 3.67172306775769e-09 11 3.19850624017024 3.84635347008965 1 24.6348947387192 1968 1019 689 1748 2324 2903 3835 11 1945 915 1242 1543 M11995 GO_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 118/201 Gene Ontology BP GO:0001816 1.92930600298104e-07 4.90549772233375e-07 2985 1782.81818181818 1749 1.75391470197541e-08 48 2.42070056375051 -2.50623779980538 -1 18.3681279305547 2983 48 408 1091 1749 3438 2637 1708 1936 484 3129 1544 M13528 GO_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neuroblast proliferation. 29/44 Gene Ontology BP GO:1902692 1.1396561610748e-07 4.06950048332718e-07 1660 1620.90909090909 1749 1.03605110919264e-08 663 1.64557435059088 1.73332159553736 1 12.6150347134665 1658 753 2330 663 1183 1895 2448 1749 2162 856 2133 1545 M13834 GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. 12/19 Gene Ontology BP GO:0060707 1.58550947733098e-07 4.44738738572283e-07 1570 2226.45454545455 1749 1.44137235599678e-08 1048 2.4164517009217 2.50825595855419 1 18.4601395390451 1749 3068 1566 3673 1570 1707 1048 2512 2500 1603 3495 1546 M14377 GO_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_FORMATION.html Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. 156/190 Gene Ontology BP GO:0035148 7.55927208031363e-08 4.02645553947883e-07 1595 1851.18181818182 1750 6.87206576368427e-09 654 1.86734277089982 1.9821803895065 1 14.3394245616669 1591 1750 1861 1599 654 769 2985 3663 2271 832 2388 1547 M13824 GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. 23/40 Gene Ontology BP GO:0046885 3.51759303819009e-07 6.95537638350604e-07 2965 2070.36363636364 1751 3.19781236420023e-08 629 2.75930273430135 2.84360686533778 1 20.4457933195716 2964 2103 870 1751 2294 3669 4472 629 1571 1070 1381 1548 M15324 GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 151/255 Gene Ontology BP GO:0043901 1.87554514695714e-07 4.82683161990685e-07 880 1976.63636363636 1753 1.70504118804658e-08 877 2.09186141678015 -2.15263532806341 -1 15.8766925085018 877 3143 1430 2398 1726 1753 1662 2165 2879 1671 2039 1549 M15726 GO_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. 159/292 Gene Ontology BP GO:0006338 4.66341974188754e-07 8.44314866109055e-07 1135 1978.54545454545 1754 4.23947339128165e-08 876 1.56245760814047 1.7050227953869 1 11.3737142458412 1133 1754 3071 2894 2519 876 1176 2222 1583 2828 1708 1550 M15741 GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. 165/214 Gene Ontology BP GO:0060759 3.57569280135628e-07 7.01420683166559e-07 860 1756.27272727273 1756 3.25063034774464e-08 786 1.96856231089718 -1.9121115391955 -1 14.5483765840826 857 1756 2139 1828 2316 786 898 2748 3113 1738 1140 1551 M14662 GO_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_ANION_GENERATION.html The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. 10/16 Gene Ontology BP GO:0042554 3.56735065327133e-07 7.00966325577344e-07 1730 1838.54545454545 1757 3.24304657429598e-08 771 2.26153994322191 -2.02145541203888 -1 16.7296783507439 1729 2732 1438 2489 2312 1757 771 1061 3220 789 1926 1552 M10421 GO_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a gland are generated and organized. 142/166 Gene Ontology BP GO:0022612 5.94002690362597e-09 1.03905808957036e-07 2565 1782.72727272727 1758 5.40002447242193e-10 189 2.50378998874702 2.81981086530023 1 21.0431942230985 2561 1758 189 569 2119 1519 3658 3828 959 370 2080 1553 M10168 GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of mitosis. 52/63 Gene Ontology BP GO:0045840 5.42307473108192e-07 9.3874876204331e-07 655 1880.90909090909 1759 4.93006915262611e-08 320 2.18150601437592 2.22930179955812 1 15.799310839055 653 3203 1759 2981 2640 893 320 1149 3478 2253 1361 1554 M14382 GO_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE.html Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. 168/350 Gene Ontology BP GO:0051321 6.44702283194816e-07 1.07097455326865e-06 40 1576.45454545455 1760 5.86093156475123e-08 36 1.66483160995843 1.80844147857651 1 11.917741122018 36 2379 3002 2871 2757 42 100 734 3052 1760 608 1555 M15417 GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. 153/211 Gene Ontology BP GO:1990267 7.12727560975965e-08 4.02645553947883e-07 4335 2130.45454545455 1760 6.47934167332718e-09 396 2.52595741894447 2.54524342945518 1 19.4332748840694 4335 1760 506 396 587 3963 2685 2773 477 1486 4467 1556 M10842 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. 52/89 Gene Ontology BP GO:0002720 6.03026890691994e-06 7.37032866401326e-06 115 1545.54545454545 1761 5.48207766921757e-07 115 1.6307604797762 -1.60636098271144 -1 10.0195765291422 115 409 2030 2086 3777 169 483 1916 3494 1761 761 1557 M15855 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. 68/82 Gene Ontology BP GO:0032233 1.06437128067951e-07 4.02645553947883e-07 1765 1697.81818181818 1761 9.67610301976673e-09 299 1.94361849839389 2.29966379919607 1 14.929355472315 2046 299 1761 1197 1093 1761 3801 2493 1347 2289 589 1558 M12735 GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is divided into specific regions along the rostrocaudal axis. 13/21 Gene Ontology BP GO:0021903 1.42876702167698e-07 4.2854237685504e-07 1765 1916 1762 1.2988791949698e-08 128 1.83869355997445 2.17624865027652 1 14.0576483573054 1762 2226 2274 2117 1450 1581 1083 4615 1544 2296 128 1559 M10452 GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. 79/108 Gene Ontology BP GO:0050848 4.80002665668575e-08 4.02645553947883e-07 3675 1908 1764 4.36366069219473e-09 168 2.14438147109541 2.27973802332972 1 16.4820942950215 3674 168 710 901 217 2919 4137 1913 1764 376 4209 1560 M11173 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. 18/22 Gene Ontology BP GO:2000010 1.0055888085605e-06 1.49632386512056e-06 1765 1570.18181818182 1764 9.14172062001074e-08 40 2.67632218205789 -3.0003284121624 -1 18.7509519688473 1764 2139 1356 779 3086 3129 2546 134 40 1953 346 1561 M14074 GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 285/421 Gene Ontology BP GO:0045089 6.52860946647107e-07 1.08143894081488e-06 695 1895 1764 5.93510127624474e-08 692 1.80226814409344 -1.88448906051861 -1 12.9008792695346 692 2780 2285 1608 2766 1764 1315 858 2885 2471 1421 1562 M14268 GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY.html Any process that modulates the activity of the enzyme phospholipase A2. 24/30 Gene Ontology BP GO:0032429 1.95175481043426e-07 4.93024708629241e-07 4455 2056.54545454545 1764 1.77432271235128e-08 389 2.89151437440953 2.68681580411472 1 21.9530160690074 4451 794 389 598 1764 3282 3079 3215 1175 444 3431 1563 M15307 GO_DOPAMINERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. 27/46 Gene Ontology BP GO:0071542 5.40690621000103e-07 9.37694170523101e-07 1055 1861.27272727273 1764 4.91537048986229e-08 551 1.83424282444543 1.80340849265784 1 13.268989977616 1053 2055 1764 1670 2635 812 551 3542 3003 1289 2100 1564 M15366 GO_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. 146/209 Gene Ontology BP GO:0010001 6.95770633552413e-08 4.02645553947883e-07 3835 2157.36363636364 1765 6.32518777778922e-09 333 2.39931846939313 2.67107746430092 1 18.4538252834326 3833 1765 333 563 567 3718 3796 2595 1711 547 4303 1565 M15401 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 7/13 Gene Ontology BP GO:0034374 1.56959601004494e-07 4.4211002269365e-07 3855 2552.36363636364 1765 1.56959612090837e-08 808 3.45932235878674 -3.42639549949505 -1 26.4822067490211 3851 1259 4552 1096 1659 4277 3126 1135 1765 808 4548 1566 M12328 GO_OVARIAN_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVARIAN_FOLLICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. 54/77 Gene Ontology BP GO:0001541 7.92612516802423e-08 4.02645553947883e-07 3145 2242.72727272727 1766 7.20556859416857e-09 277 2.10985592401704 -2.34649755915655 -1 16.2150671803978 3145 3202 1489 1560 717 4185 3761 277 2856 1712 1766 1567 M14300 GO_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 65/100 Gene Ontology BP GO:0046631 1.36139851505791e-06 1.92306839422114e-06 290 1994.72727272727 1767 1.23763577955988e-07 289 1.68324050593563 -1.43047779437768 -1 11.5331518189892 289 1882 2502 3444 3264 936 1177 1147 3893 1641 1767 1568 M10571 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. 14/23 Gene Ontology BP GO:1901017 2.93289059868638e-07 6.1534076669006e-07 1770 1561.27272727273 1768 2.66626453607228e-08 436 2.33821470073068 -2.24655165001618 -1 17.4603711847077 1768 1094 1801 1164 2159 1416 436 1943 851 2483 2059 1569 M12738 GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. 3/14 Gene Ontology BP GO:0007210 4.98966541818042e-07 8.85761224420011e-07 2700 1791.72727272727 1768 4.98966653853501e-08 6 4.20968400723631 3.96276021691795 1 30.7123464741532 2699 1291 4384 46 2654 2359 1079 1631 6 1768 1792 1570 M16105 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. 147/216 Gene Ontology BP GO:1903035 8.24740826669881e-09 1.40055440383028e-07 4350 2250.72727272727 1768 7.49764390692444e-10 162 2.45448688242706 -2.17135439865483 -1 20.2419074094594 4348 1768 195 1725 816 4517 3018 1355 3083 162 3771 1571 M11752 GO_PURINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. 16/17 Gene Ontology BP GO:0043101 1.29272151184639e-07 4.18582685777402e-07 940 2290.36363636364 1769 1.17520144346073e-08 845 1.13968409151862 1.14353627157097 1 8.68833824709612 938 2681 3442 4322 1330 1211 845 1194 4229 3233 1769 1572 M14535 GO_PIRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. 3/15 Gene Ontology BP GO:0034587 3.0937231627752e-08 3.82848241393431e-07 3085 1817.09090909091 1769 3.09372320584525e-09 89 2.18937951897725 -1.77941268541419 -1 16.888095259033 3082 1293 4499 1335 89 2118 291 2212 183 1769 3117 1573 M10771 GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 35/41 Gene Ontology BP GO:0043537 1.61514108018413e-07 4.4655132638076e-07 1560 1920.18181818182 1770 1.46831018069139e-08 694 1.91745428021376 1.86875891147601 1 14.6227625556112 1560 694 1943 787 1596 1209 1819 4598 1770 2314 2832 1574 M12333 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 158/210 Gene Ontology BP GO:0090288 7.92365896081289e-08 4.02645553947883e-07 2400 1951.09090909091 1771 7.20332658745128e-09 716 2.19478051807813 2.44564719956335 1 16.8718900617629 2399 2809 1227 1384 716 1883 4190 1427 2641 1771 1015 1575 M13347 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. 37/78 Gene Ontology BP GO:0032732 4.2046814553227e-06 5.29196181001259e-06 1105 2280.90909090909 1771 3.82244499219148e-07 722 2.1466801065439 -2.50286268109835 -1 13.5955316150317 1103 3231 1470 3296 3673 1771 1248 722 4300 1687 2589 1576 M12897 GO_RESPONSE_TO_GROWTH_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 34/67 Gene Ontology BP GO:0060416 1.02132332994851e-05 1.20248417364637e-05 500 1825.90909090909 1772 9.28480064862797e-07 253 1.76929417114306 -2.1338929574579 -1 10.4245883340408 497 2551 2873 2129 4277 830 748 253 1772 3544 611 1577 M14993 GO_MEIOTIC_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE_PROCESS.html A process that is part of the meiotic cell cycle. 135/298 Gene Ontology BP GO:1903046 4.17707947745994e-07 7.84794997995146e-07 15 1384.27272727273 1772 3.79734570050067e-08 13 1.73311089002692 1.84235962925638 1 12.6937534471055 13 1813 2717 2406 2429 23 51 555 2925 1772 523 1578 M12351 GO_RESPONSE_TO_TESTOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TESTOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. 45/66 Gene Ontology BP GO:0033574 1.03090922544473e-07 4.02645553947883e-07 4350 2689.45454545455 1773 9.37190248866029e-09 501 2.10715575890095 1.60890183904359 1 16.1941835924182 4350 501 1479 1089 1047 4529 4458 4437 1330 1773 4591 1579 M12642 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. 125/180 Gene Ontology BP GO:1903169 1.51296178220252e-07 4.37569031250903e-07 2660 1816.63636363636 1773 1.37541989659128e-08 524 2.26743549694762 2.32337704633277 1 17.3347579904581 2659 1807 524 891 1513 1246 3263 3674 1773 833 1800 1580 M14398 GO_CELLULAR_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, as carried out by individual cells. 802/1131 Gene Ontology BP GO:0044255 7.52288455304007e-08 4.02645553947883e-07 1405 1826.81818181818 1773 7.52288480771212e-09 779 1.83434318614137 -1.77085987684289 -1 14.0841995283944 1405 1385 4491 2354 779 924 1773 1800 2297 1104 1783 1581 M11861 GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 66/115 Gene Ontology BP GO:0033555 4.61065140679854e-07 8.38349394131832e-07 1310 1596 1774 4.19150215734217e-08 180 2.6457350197554 2.80572290862877 1 19.3405318948144 1310 1888 580 1774 2509 1805 2998 180 2290 1163 1059 1582 M11947 GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT.html The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. 135/243 Gene Ontology BP GO:0015850 6.48988198293036e-11 1.70606897551271e-09 450 1627.90909090909 1774 5.89989271192891e-12 20 2.80156676471213 -2.6836536729632 -1 29.6048562422207 2913 1774 122 20 449 3503 2587 3096 453 450 2540 1583 M10192 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT.html The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/32 Gene Ontology BP GO:0043252 3.94258512117527e-07 7.51011780073326e-07 2725 1715.27272727273 1775 3.94258582065442e-08 24 3.25058666612367 1.75551361175228 1 23.9734112708729 2723 1263 4231 59 2457 1775 315 1086 24 1910 3025 1584 M12196 GO_BASE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASE_EXCISION_REPAIR.html In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. 41/43 Gene Ontology BP GO:0006284 1.06318922453987e-05 1.2483016557618e-05 435 1827.18181818182 1775 9.66540329660112e-07 134 2.05780754705714 2.12128510187034 1 12.1008659622194 434 3703 2760 3522 3938 134 146 518 1775 2701 468 1585 M13731 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of phagocytosis. 65/79 Gene Ontology BP GO:0050766 4.39487316555681e-07 8.13003638007822e-07 1775 2063.18181818182 1775 3.99534003955228e-08 1306 2.34563857692822 -2.0237805114598 -1 17.1729470044599 1775 2462 1306 1538 2467 1461 1547 3072 1894 1640 3533 1586 M10285 GO_AMMONIUM_ION_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_METABOLIC_PROCESS.html The chemical reactions and pathways involving the ammonium ion. 145/208 Gene Ontology BP GO:0097164 6.2259875883773e-08 4.02645553947883e-07 1235 1680 1776 5.659988876884e-09 439 1.91849238108824 -1.94187923366953 -1 14.7350253262757 2065 2387 1657 1904 439 1235 1776 1232 2677 791 2317 1587 M12726 GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 36/52 Gene Ontology BP GO:0051491 7.36602013111746e-07 1.17457476593864e-06 1425 1662.72727272727 1776 6.69638417945711e-08 411 2.58742319764387 3.32363804611472 1 18.4537064581299 1422 1985 1299 1776 2875 2348 2066 411 611 1834 1663 1588 M11628 GO_MEMBRANE_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. 20/24 Gene Ontology BP GO:0046466 1.53486392180139e-07 4.39394452489232e-07 1410 1971.63636363636 1777 1.39533093534868e-08 983 1.65619800997279 -1.74240046046191 -1 12.6304138502856 1406 2127 3127 2723 1531 1271 983 1777 2875 2644 1224 1589 M12955 GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. 151/264 Gene Ontology BP GO:1903707 7.02384059203859e-07 1.13321533546309e-06 1140 1827.54545454545 1778 6.38531166773584e-08 358 1.83553726574989 -1.90483493044636 -1 13.0958376825987 358 1778 2180 3020 2840 1139 1353 487 3413 2396 1139 1590 M10689 GO_PHOTOPERIODISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOPERIODISM.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. 36/67 Gene Ontology BP GO:0009648 2.21623491233797e-08 3.23264609627227e-07 1780 2218.72727272727 1779 2.0147590315126e-09 18 2.16208550468379 2.37078548107463 1 16.868382331415 3924 636 1779 775 18 4142 4310 4452 163 2428 1779 1591 M12194 GO_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. 137/235 Gene Ontology BP GO:0009913 5.45323660943109e-08 4.02645553947883e-07 4400 2098.90909090909 1779 4.95748794963898e-09 247 2.50034175042946 -1.88681430748619 -1 19.2351584563356 4396 1779 247 882 322 4632 3361 2584 929 498 3458 1592 M11805 GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE.html An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. 17/108 Gene Ontology BP GO:0002251 9.03417765244845e-06 1.07233424008873e-05 875 2055.81818181818 1780 8.21292250091804e-07 785 4.07671633445411 -4.70199771600678 -1 24.3993527222434 873 3565 1363 1933 3893 1780 1517 868 3444 2593 785 1593 M13754 GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION.html The directed movement of the nucleus to a specific location within a cell. 19/29 Gene Ontology BP GO:0040023 1.97500481881029e-07 4.93246485651519e-07 4435 2131.36363636364 1781 1.79545908737483e-08 180 2.42987573592739 2.98311450663268 1 18.4311420387588 4435 971 1559 1759 1781 3761 1872 1200 180 2924 3003 1594 M14852 GO_MISMATCH_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR.html A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. 30/34 Gene Ontology BP GO:0006298 1.43658127388122e-05 1.65860781051024e-05 635 2211.72727272727 1781 1.30599150429128e-06 355 1.67111375595441 1.95059372059036 1 9.55813393673024 631 3735 2911 3961 4004 743 355 1540 1180 3488 1781 1595 M11236 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. 15/18 Gene Ontology BP GO:0045955 5.4577057920081e-07 9.43339712117894e-07 1080 1900 1782 4.96155195085707e-08 421 1.71161877490719 -1.36770784774111 -1 12.3696430681786 1079 3340 2967 2601 2645 1782 520 421 985 3467 1093 1596 M15753 GO_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. 425/611 Gene Ontology BP GO:0048732 2.03889054810026e-08 3.0406915770226e-07 3125 2038.72727272727 1782 1.85353687908733e-09 214 2.14101983881238 2.35818409746972 1 16.7718666493774 3123 1488 214 524 539 2668 4398 4159 1782 408 3123 1597 M14095 GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. 15/21 Gene Ontology BP GO:1900273 1.79707727370086e-06 2.45646314762929e-06 1130 2040.72727272727 1784 1.6337079469555e-07 941 3.13815885314612 3.11232526325709 1 21.1873909775264 1129 3343 1707 2041 3373 1508 941 969 3696 1784 1957 1598 M11235 GO_CELLULAR_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENTATION.html The deposition or aggregation of coloring matter in a cell. 48/56 Gene Ontology BP GO:0033059 4.54171615467207e-07 8.29813403313878e-07 1075 1988.18181818182 1786 4.12883372024699e-08 940 1.64992702228723 -1.52570768715733 -1 12.0312141579873 1074 1932 3095 3374 2496 1031 1295 1786 940 3528 1319 1599 M15692 GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 38/54 Gene Ontology BP GO:0006213 3.25950383439458e-07 6.62291324953623e-07 385 1711 1786 2.96318574301852e-08 385 1.6632604268169 1.903262183734 1 12.326266087583 385 1966 2524 3382 2234 1255 1276 783 592 2638 1786 1600 M16678 GO_LENS_FIBER_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. 15/29 Gene Ontology BP GO:0070307 2.43728112385956e-08 3.39987841817087e-07 4345 2104.54545454545 1786 2.21571013714646e-09 30 2.45287050178218 -1.75650748372396 -1 19.0859241432824 4341 1054 1391 643 30 4097 3183 2541 133 1786 3951 1601 M12835 GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. 25/27 Gene Ontology BP GO:2000369 5.14074344673061e-07 9.0127653570601e-07 1790 2003.45454545455 1787 4.67340422542666e-08 469 1.41623506980406 -1.45851145247563 -1 10.2511064729446 1787 2958 3258 3238 2608 1221 469 651 1513 3285 1050 1602 M15174 GO_VISUAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VISUAL_BEHAVIOR.html The behavior of an organism in response to a visual stimulus. 51/78 Gene Ontology BP GO:0007632 5.1882939241316e-08 4.02645553947883e-07 1460 1454.09090909091 1787 4.71663095135269e-09 183 1.70281600350102 1.5902997343507 1 13.0669434080116 1460 1913 2723 1849 267 598 1367 1787 1921 1927 183 1603 M11274 GO_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORT.html The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 128/215 Gene Ontology BP GO:0006836 1.79760477214984e-07 4.72066258868601e-07 2925 1957.18181818182 1791 1.63418629002808e-08 357 2.11824409035568 -2.04691005719336 -1 16.1029736531957 2923 1791 357 1043 1688 1702 2264 4645 1854 362 2900 1604 M11596 GO_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BINDING.html Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. 14/21 Gene Ontology BP GO:1900120 2.33154649830511e-07 5.37133724763818e-07 2565 1545.45454545455 1791 2.11958795036456e-08 602 2.09343609762447 2.55042119516682 1 15.7711947745641 2563 1105 1791 1936 1956 1827 638 746 2630 1206 602 1605 M15686 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. 38/69 Gene Ontology BP GO:0002711 5.22201339799788e-06 6.46396071851135e-06 210 1845.72727272727 1793 4.74729617566524e-07 210 1.27945930024873 -1.31248043431178 -1 7.92714508513973 210 585 3142 2560 3735 411 759 1854 4076 1793 1178 1606 M15319 GO_PROTEIN_HOMOTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTRIMERIZATION.html The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. 16/23 Gene Ontology BP GO:0070207 3.66120530005806e-08 4.02645553947883e-07 2930 1824.54545454545 1794 3.32836850998843e-09 113 1.80888539800712 0.842412947749936 1 13.8873041774023 2926 1073 2670 1794 113 3543 1991 808 552 2870 1730 1607 M15877 GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the inflammatory response. 97/167 Gene Ontology BP GO:0050729 1.98534770505699e-07 4.93246485651519e-07 930 1725 1794 1.80486171292809e-08 502 2.50240998688716 -2.56100957341011 -1 18.9844036846482 928 2420 502 1531 1794 2317 1820 1003 3251 1050 2359 1608 M10114 GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 13/25 Gene Ontology BP GO:0090185 3.33413543886437e-06 4.28083118019755e-06 1785 1988.90909090909 1795 3.03103681073732e-07 1042 2.37062402381206 -1.79472364587668 -1 15.2885928264789 1795 2237 1896 1435 3600 2486 1785 1042 1048 2772 1782 1609 M15418 GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. 49/55 Gene Ontology BP GO:2000249 1.07130935644161e-07 4.02645553947883e-07 3560 2232.72727272727 1796 9.73917644190881e-09 444 2.4402930176959 2.39797774910596 1 18.7707301939171 3560 444 768 595 1102 3325 3717 3595 1796 1095 4563 1610 M11876 GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 24/42 Gene Ontology BP GO:0060079 1.9902872496826e-07 4.93878508235586e-07 2510 1999.09090909091 1797 1.80935220885376e-08 894 2.48119182170238 2.76618704928759 1 18.8208913858502 2238 894 1570 1406 1797 2732 3245 1528 1564 2510 2506 1611 M13524 GO_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of T cell proliferation. 131/232 Gene Ontology BP GO:0042129 1.98131632702702e-07 4.93246485651519e-07 1900 2028 1797 1.80119682314915e-08 723 1.92913848430181 -1.82725896703302 -1 14.6117227668044 1898 1797 1084 1561 1789 2012 2943 3876 3031 723 1594 1612 M11103 GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 374/577 Gene Ontology BP GO:0019221 3.40005872057571e-07 6.81916949432706e-07 845 2052.36363636364 1798 3.0909629509532e-08 843 2.01444461510187 -1.94506281343761 -1 14.9196999705748 843 3412 1019 3423 2263 1411 1536 1798 3698 1362 1811 1613 M15119 GO_OSTEOBLAST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DEVELOPMENT.html The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. 24/31 Gene Ontology BP GO:0002076 7.59852206666468e-08 4.02645553947883e-07 3785 2081 1799 6.90774757191639e-09 116 2.87407924231914 -2.91686743430098 -1 22.1257149436657 3784 881 1029 164 659 4382 3747 3563 116 1799 2767 1614 M16171 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 18/20 Gene Ontology BP GO:0090005 1.03579968155695e-07 4.02645553947883e-07 1160 2390.63636363636 1799 9.41636118476609e-09 1056 1.18417529289245 -1.29956868539094 -1 9.05567800602284 1160 2649 3432 3920 1056 1799 1224 1519 4204 3782 1552 1615 M15458 GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 13/32 Gene Ontology BP GO:0045408 5.18382641884082e-06 6.42352711767413e-06 600 1634.36363636364 1800 4.71258057586562e-07 93 2.22418207862519 -1.96394956210142 -1 13.8637153912128 600 1160 1800 2094 3731 436 93 2413 3080 1819 752 1616 M15714 GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 250/307 Gene Ontology BP GO:0043244 9.80962353059209e-08 4.02645553947883e-07 2445 1842 1800 8.91783997090487e-09 983 1.71547552657057 2.00118643571179 1 13.1648545550848 1800 1600 2441 1906 983 1763 2443 2334 1476 2262 1254 1617 M14692 GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT.html The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. 19/24 Gene Ontology BP GO:0060749 1.72737773839435e-06 2.37204947025173e-06 995 1962.90909090909 1801 1.57034463153087e-07 112 2.2967260276257 -2.99794119846394 -1 15.5210042243272 995 2992 1345 2101 3556 1801 2131 112 4245 1728 586 1618 M14258 GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. 31/50 Gene Ontology BP GO:1901532 1.23390943517539e-07 4.14338946095474e-07 1710 1866 1802 1.12173591307402e-08 395 2.15937022645303 -2.49629189441177 -1 16.5655513247272 1710 2033 2138 2993 1271 2473 1533 395 2508 1802 1670 1619 M15053 GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT.html The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. 19/24 Gene Ontology BP GO:0061377 5.48513735143647e-07 9.46061231344861e-07 1000 1959.27272727273 1802 4.9864897445597e-08 62 2.2967260276257 -2.99794119846394 -1 16.629856331349 996 2993 1346 2102 3557 1802 2132 62 4246 1729 587 1620 M16333 GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. 31/61 Gene Ontology BP GO:0046640 1.74253837781296e-06 2.38963485763739e-06 405 1954 1803 1.58412705274044e-07 405 1.55103485284129 -1.53981766375061 -1 10.4422658660116 405 697 2371 2897 3361 1112 2278 1487 3716 1803 1367 1621 M14460 GO_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE.html The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. 1438/1842 Gene Ontology BP GO:0007049 1.82490117886038e-07 4.75434780808363e-07 500 2158.81818181818 1806 1.82490132872229e-08 499 1.58278085385995 1.73357595282251 1 12.0004239891975 499 3107 4495 3385 1806 513 837 1670 2575 3417 1443 1622 M11377 GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. 82/102 Gene Ontology BP GO:0008652 4.19367601178809e-07 7.86504412851672e-07 1010 1750.45454545455 1807 3.81243346472153e-08 185 1.9013644006928 1.82999058963234 1 13.9339082164414 1007 185 1807 3137 2433 1469 1893 1369 2199 1279 2477 1623 M16570 GO_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_GROWTH.html The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. 172/205 Gene Ontology BP GO:0016049 2.59608198801054e-07 5.68695377458746e-07 2220 1710.72727272727 1807 2.36007481305268e-08 407 2.27004767797893 2.68740729660968 1 17.0423307031872 2220 1709 450 491 2064 1982 4396 1850 1442 407 1807 1624 M11271 GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 90/224 Gene Ontology BP GO:0038094 3.60019990234861e-08 4.02645553947883e-07 2890 1773.36363636364 1808 3.27290905569476e-09 107 2.11141050305289 -1.57244219325409 -1 16.2270905888454 2890 148 1808 224 107 2037 940 3776 636 2561 4380 1625 M14836 GO_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 130/167 Gene Ontology BP GO:0033273 8.30258716699192e-11 2.13436122033223e-09 3925 2187.09090909091 1808 7.54780651573202e-12 125 2.68921260123944 2.65052542112477 1 28.0970945391548 3339 1808 125 155 1739 3924 2738 4169 1785 353 3923 1626 M15718 GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of smoothened signaling. 27/42 Gene Ontology BP GO:0045880 3.21433301080445e-07 6.55690113953227e-07 1115 1860.90909090909 1808 2.92212134585276e-08 178 2.11257344740042 1.74956907079231 1 15.6950105917315 1114 2954 2068 3393 2224 1124 178 543 3508 1556 1808 1627 M12612 GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. 31/40 Gene Ontology BP GO:0045822 4.60627492668738e-08 4.02645553947883e-07 1810 1769 1809 4.18752274830161e-09 191 2.18234055505376 -2.66092464540684 -1 16.7756770336281 1809 742 1596 2421 191 2786 2611 532 3663 1265 1843 1628 M14737 GO_RESPONSE_TO_PARATHYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PARATHYROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. 22/27 Gene Ontology BP GO:0071107 1.67493308926069e-07 4.54807218431838e-07 2960 2011.81818181818 1809 1.52266656070812e-08 438 2.35944831559304 2.58831676811274 1 17.9944985899832 2957 918 1291 1809 1628 2757 4065 2399 438 2582 1286 1629 M10474 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE.html Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. 19/21 Gene Ontology BP GO:0090178 7.88033545778387e-07 1.24253476398063e-06 1365 1915.72727272727 1810 7.16394389136211e-08 1073 1.84763849427585 1.89073061901323 1 13.093481510579 1361 2146 2421 2508 2904 1334 1575 1714 2227 1073 1810 1630 M10841 GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 517/769 Gene Ontology BP GO:0071407 6.47579389799865e-08 4.02645553947883e-07 2195 1925.81818181818 1810 6.47579408671022e-09 568 2.17095834149299 2.24076387145738 1 16.6876448400103 2191 1451 4265 568 585 1218 3305 2841 1810 733 2217 1631 M14679 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of production of a cytokine. 352/572 Gene Ontology BP GO:0001819 1.60388678284697e-07 4.46344808647544e-07 1255 1711.81818181818 1811 1.45807899979696e-08 402 2.02355655593352 -2.08065545946856 -1 15.4381015035591 1252 1536 703 2391 1586 1811 2053 1884 3240 402 1972 1632 M13378 GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION.html Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 16/24 Gene Ontology BP GO:0010935 3.05140568154606e-07 6.32560372007763e-07 2500 1819.81818181818 1813 2.77400554979718e-08 1058 2.4374434342082 -2.61211431242099 -1 18.1703869253744 2497 1058 1312 1194 2187 1813 1135 2427 2548 1542 2305 1633 M14096 GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. 88/106 Gene Ontology BP GO:0008286 1.04807601060704e-07 4.02645553947883e-07 920 2120.63636363636 1814 9.52796418670174e-09 348 1.38461328422585 -1.31976040229976 -1 10.6059033613297 920 2836 3630 2980 1074 348 513 1814 3593 4098 1521 1634 M15479 GO_NEGATIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. 272/388 Gene Ontology BP GO:0007162 2.41909438627506e-12 8.04003298524133e-11 4350 2359.54545454545 1814 2.19917671479793e-13 90 2.31665175903736 2.43969850314383 1 28.1800111070412 4349 1573 90 685 762 3770 4506 4430 1814 134 3842 1635 M14282 GO_METANEPHRIC_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. 13/23 Gene Ontology BP GO:0072075 5.64909880754597e-06 6.95009432879731e-06 2475 2018.45454545455 1815 5.13555755745174e-07 943 2.67682808483748 -2.20856613772752 -1 16.5953172714983 2475 1164 1428 943 3756 2355 1305 3612 1253 1815 2097 1636 M15318 GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY.html Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. 58/75 Gene Ontology BP GO:0034260 1.03345007800826e-07 4.02645553947883e-07 3610 2052.45454545455 1815 9.39500115049622e-09 348 1.7064120596027 2.05934387740396 1 13.0947559864097 3609 348 2299 1815 1053 4364 2892 1451 1941 1428 1377 1637 M10567 GO_RESPONSE_TO_AMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. 51/77 Gene Ontology BP GO:0014075 1.55101384044395e-07 4.40859340231257e-07 1820 1694.18181818182 1816 1.41001268162855e-08 449 1.64768830505614 1.73646049805006 1 12.5621081441313 1816 449 2270 2275 1545 1317 1567 635 2114 2622 2026 1638 M12688 GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. 7/16 Gene Ontology BP GO:2001053 1.45139447276258e-06 2.03340931392983e-06 3875 2221.72727272727 1816 1.45139542070911e-07 633 2.52015066865431 2.79730927420914 1 17.2447961720778 3872 1276 4382 650 3329 2955 1660 1816 633 807 3059 1639 M16930 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 49/86 Gene Ontology BP GO:0045980 6.83085717043681e-07 1.11016340950201e-06 2040 1658 1817 6.20987208306776e-08 657 2.3888663401034 2.63087874937864 1 17.1004470121901 2040 1915 1176 1341 2818 931 1817 2190 1389 1964 657 1640 M10380 GO_ANTIMICROBIAL_HUMORAL_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIMICROBIAL_HUMORAL_RESPONSE.html An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. 43/176 Gene Ontology BP GO:0019730 6.15852720245877e-06 7.51278690652765e-06 495 1980.81818181818 1819 5.59867676570877e-07 494 2.21134497650582 -2.11373418099408 -1 13.6011728482587 494 550 1204 3396 3786 1008 1226 2785 3426 2095 1819 1641 M10384 GO_INTERMEDIATE_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. 51/72 Gene Ontology BP GO:0045103 2.03013152469555e-07 4.99270717991986e-07 3090 1819.09090909091 1819 1.8455742836668e-08 397 3.2191013862299 4.53387048673839 1 24.4305078272944 3086 439 413 397 1819 2877 3107 2839 759 787 3487 1642 M16879 GO_INOSITOL_LIPID_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_LIPID_MEDIATED_SIGNALING.html A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. 120/158 Gene Ontology BP GO:0048017 4.2446994599698e-08 4.02645553947883e-07 2015 1534.90909090909 1819 3.858817765334e-09 43 2.14468727669743 -2.18191009688822 -1 16.4844594534174 2013 43 1044 244 160 1819 2267 3162 1652 1978 2502 1643 M13803 GO_COENZYME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 123/138 Gene Ontology BP GO:0009108 3.11013520723711e-08 3.8385833207624e-07 500 2132 1820 2.82739568291365e-09 71 1.45654449111249 -1.52596681294763 -1 11.1987883143635 498 1820 3589 4302 71 1569 1600 1538 2989 3482 1994 1644 M14492 GO_TRACHEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_MORPHOGENESIS.html The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. 15/21 Gene Ontology BP GO:0060439 2.74262259774031e-06 3.57362726051125e-06 1820 2171.18181818182 1820 2.4932963789341e-07 666 1.9188975606977 2.22719288033631 1 12.5376939008478 1820 3042 2853 666 3541 1145 1105 4080 821 3473 1337 1645 M15404 GO_ADULT_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. 14/29 Gene Ontology BP GO:0007512 2.27068015072585e-07 5.26693656098074e-07 4400 1953.54545454545 1821 2.06425489553544e-08 91 2.75326775143114 -1.72695472717687 -1 20.8029648085762 4397 1062 1282 111 1940 4164 3289 837 91 2495 1821 1646 M15598 GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 55/82 Gene Ontology BP GO:0050994 2.0059455809916e-07 4.95680551691657e-07 1825 1850 1821 1.82358705808402e-08 759 2.22081891089253 -2.33184192140342 -1 16.8307999189649 1821 2867 1984 1592 1805 1920 2331 1454 1756 2061 759 1647 M16106 GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT.html The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. 13/18 Gene Ontology BP GO:0021891 2.33407151945064e-07 5.37133724763818e-07 3280 2039.18181818182 1821 2.12188342462004e-08 419 2.74508954368641 3.76796870552274 1 20.7125666367381 3277 1108 1148 640 1958 3902 4518 750 419 1821 2890 1648 M16044 GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 14/17 Gene Ontology BP GO:0060547 4.79225661308688e-07 8.58620331948142e-07 2865 2266.27272727273 1822 4.35659786998519e-08 1026 1.84732903335448 -1.99430589625457 -1 13.4498695767055 2864 1074 1822 1585 2548 3727 4466 1026 1608 1572 2637 1649 M15854 GO_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_MEDIATED_ENDOCYTOSIS.html An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. 204/399 Gene Ontology BP GO:0006898 9.53053370740299e-08 4.02645553947883e-07 4290 2518.90909090909 1823 8.66412192751959e-09 292 2.38297442722652 2.5415696913446 1 18.3274173684145 4288 1651 292 843 948 4269 3983 4622 1823 487 4502 1650 M14689 GO_DENDRITIC_SPINE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. 33/39 Gene Ontology BP GO:0097061 7.37050162152565e-08 4.02645553947883e-07 655 2066.72727272727 1824 6.70045624404932e-09 628 1.86381005199635 -1.02948193621065 -1 14.3121018451455 3650 655 2104 651 628 3662 3933 3043 818 1766 1824 1651 M12330 GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 54/78 Gene Ontology BP GO:0045661 2.0391454815593e-07 4.99381053281994e-07 4120 2281.09090909091 1825 1.85376879142229e-08 405 2.40286120709384 -1.85805323648958 -1 18.2094865832331 4119 405 1015 1552 1825 4265 4489 2167 823 973 3459 1652 M12909 GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 90/133 Gene Ontology BP GO:0048259 7.97770554308049e-08 4.02645553947883e-07 2305 1804.09090909091 1827 7.2524598476095e-09 134 1.95806891712762 -1.87787012045496 -1 15.0411177453592 2301 134 1661 565 731 3031 2713 1503 2956 1827 2423 1653 M10193 GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. 70/79 Gene Ontology BP GO:0061097 8.58339212765216e-07 1.32695173651424e-06 1825 2000.18181818182 1828 7.80308679681853e-08 294 1.86681400057243 -1.73668661188407 -1 13.1659890787605 1822 294 1994 1640 2968 1997 1443 4236 1266 1828 2514 1654 M12610 GO_PROTEIN_HETEROTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTETRAMERIZATION.html The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. 18/43 Gene Ontology BP GO:0051290 2.58392053870875e-06 3.38580182106782e-06 1755 2196.72727272727 1830 2.34902143050231e-07 140 1.58096712990435 1.85619870492253 1 10.3564247759331 1753 1040 2815 3711 3804 1164 730 140 4024 3153 1830 1655 M14858 GO_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a second cell of the identical type via adhesion molecules. 75/108 Gene Ontology BP GO:0034109 7.14711020670086e-08 4.02645553947883e-07 2755 1936.72727272727 1830 6.4973731262619e-09 234 2.27371975956295 2.50346631244509 1 17.4824210936516 2755 234 784 1265 593 3002 4628 2943 621 1830 2649 1656 M15415 GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. 13/13 Gene Ontology BP GO:1904293 0.00207967688514665 0.00213331934448575 915 2363.54545454545 1830 0.000189240493217055 225 1.18848856692643 -1.30759495553795 -1 3.73613686855788 911 4077 3542 3470 4532 1279 225 1830 1532 3902 699 1657 M16741 GO_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 330/422 Gene Ontology BP GO:0009100 8.59401555230577e-08 4.02645553947883e-07 1830 1767.09090909091 1830 7.81274171638173e-09 449 2.09646738004621 2.32112439183115 1 16.1115176477161 1830 1543 449 1255 832 2376 3552 2411 2012 699 2479 1658 M10974 GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. 98/165 Gene Ontology BP GO:0048525 4.76335959175256e-06 5.94366108351426e-06 375 1942.54545454545 1831 4.3303362774872e-07 375 2.17557056540184 -2.36358236010344 -1 13.6471815301081 375 3175 1437 1973 3703 1667 1406 1014 2908 1879 1831 1659 M13563 GO_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENTATION.html The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. 100/137 Gene Ontology BP GO:0035282 8.07870655213539e-08 4.02645553947883e-07 2470 1833.36363636364 1831 7.3442789534516e-09 749 2.18529817343859 2.84149391887367 1 16.7985518139079 2466 1837 1184 770 749 1831 3757 2689 2088 1221 1575 1660 M12749 GO_POSITIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 257/394 Gene Ontology BP GO:0043270 1.5798550652321e-16 9.54683846561686e-15 2560 1768.90909090909 1832 1.43623187748373e-17 42 2.58001788360306 2.89513608774386 1 43.6436204934659 2558 1581 42 841 1650 1832 4004 2600 2048 155 2147 1661 M12762 GO_MYELOID_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_ACTIVATION.html A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. 105/180 Gene Ontology BP GO:0002274 2.30237929917791e-07 5.3192506847442e-07 1185 1727.81818181818 1832 2.09307230920931e-08 1133 1.91990480049573 -1.93214459217842 -1 14.4651642091101 1185 1832 1478 1620 1950 2182 1580 1133 2066 1998 1982 1662 M16155 GO_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 421/571 Gene Ontology BP GO:0097305 1.09146254386713e-19 1.0580365034612e-17 2490 1753.90909090909 1834 9.92238676242847e-21 25 2.36725765864778 2.41734131484611 1 48.4971349794748 2487 1481 25 394 875 1834 4113 3341 1838 104 2801 1663 M13625 GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. 104/159 Gene Ontology BP GO:0046887 5.31698171259315e-08 4.02645553947883e-07 3985 2077.72727272727 1835 4.83361985554045e-09 294 2.32462807854134 -2.03760522781561 -1 17.8761556663807 3983 1835 691 746 294 3691 2711 1805 2806 1036 3257 1664 M15602 GO_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINESIS.html The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. 102/118 Gene Ontology BP GO:0000910 1.12638809371434e-07 4.05064193023647e-07 2660 1576.72727272727 1835 1.02398922853163e-08 78 1.88856787191468 2.23331373016591 1 14.4976428733488 2656 78 1904 686 1175 2612 2793 1861 293 1451 1835 1665 M15820 GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION.html Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. 12/29 Gene Ontology BP GO:0007263 5.55808803229937e-06 6.85080360643417e-06 1185 2197.72727272727 1835 5.0528200675663e-07 972 3.05109754562575 3.05250796392872 1 18.9531005465058 1904 1183 972 1137 3749 1835 2321 4438 3856 1183 1597 1666 M12903 GO_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 403/509 Gene Ontology BP GO:0070482 8.05464712367296e-08 4.02645553947883e-07 2430 2011.09090909091 1836 7.32240674415453e-09 431 2.20677665631691 2.45377076680165 1 16.9646704650179 2429 3410 431 1836 738 1063 3893 3575 2395 741 1611 1667 M13887 GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 36/43 Gene Ontology BP GO:0010800 6.77134323655833e-08 4.02645553947883e-07 2700 1843.09090909091 1836 6.15576676815669e-09 528 2.08733318496765 -1.89991808498596 -1 16.0408720544486 2697 650 1694 805 528 2876 2535 3208 637 1836 2808 1668 M16060 GO_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTOSIS.html A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. 485/858 Gene Ontology BP GO:0006897 6.94476697398812e-08 4.02645553947883e-07 2635 1734.18181818182 1836 6.31342472110404e-09 545 2.0899269042795 -1.86700215682704 -1 16.0609323704348 2635 1457 545 684 564 1970 1905 3571 1836 632 3277 1669 M14522 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 38/45 Gene Ontology BP GO:1902042 1.42828004256076e-07 4.2854237685504e-07 1695 2079.90909090909 1837 1.29843648662483e-08 1099 2.12350141480667 -1.86173749961059 -1 16.2510817550044 1693 2526 1993 3895 1448 1837 1319 1941 3615 1099 1513 1670 M11659 GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 26/33 Gene Ontology BP GO:0046134 6.02521900921167e-07 1.01736567508237e-06 920 1982.09090909091 1839 5.47747332669152e-08 803 1.25753325212895 1.38799581343667 1 9.01081486300965 918 803 3014 3399 2713 1394 1674 1111 1839 2794 2144 1671 M16891 GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. 27/55 Gene Ontology BP GO:0090022 9.24282625978883e-07 1.40729288569363e-06 2495 1821.36363636364 1839 8.40257285724138e-08 687 2.63745549587465 -3.05769131401291 -1 18.562125485873 2495 790 687 1749 3020 2535 1965 1839 3204 860 891 1672 M16893 GO_EMBRYO_IMPLANTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_IMPLANTATION.html Attachment of the blastocyst to the uterine lining. 36/60 Gene Ontology BP GO:0007566 1.63478804927286e-06 2.25851211201503e-06 1610 1947.54545454545 1839 1.48617205823762e-07 708 2.52075051511818 2.10472746629868 1 17.1099168981807 1609 1994 1297 2207 3338 904 1352 2796 708 1839 3379 1673 M12424 GO_NEGATIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 457/670 Gene Ontology BP GO:0051051 8.25839855308098e-08 4.02645553947883e-07 2830 1632.09090909091 1840 7.50763533007836e-09 133 2.0330765145997 -1.97396110244746 -1 15.6212406984398 2829 1470 519 133 777 2324 2451 2986 1840 495 2129 1674 M14259 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. 27/47 Gene Ontology BP GO:0010574 9.52659710939175e-08 4.02645553947883e-07 1875 1760.54545454545 1840 8.66054320174479e-09 756 2.17691113897409 1.78185051190085 1 16.7336849022202 1871 2038 1210 756 947 1840 1284 3229 2191 858 3142 1675 M15012 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 101/120 Gene Ontology BP GO:0071158 6.63344762403381e-07 1.08889474390276e-06 635 1821 1840 6.03040874923097e-08 387 1.76279632064204 1.79348782715705 1 12.6097182822251 633 1840 2834 2547 2788 387 850 1890 1594 3244 1424 1676 M11308 GO_REGULATION_OF_HEAT_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEAT_GENERATION.html Any process that modulates the rate or extent of heat generation. 14/18 Gene Ontology BP GO:0031650 1.96574370051096e-07 4.93246485651519e-07 1935 1985.09090909091 1841 1.78703988741281e-08 285 2.64563472545538 -2.51484450401604 -1 20.0768635025112 1935 2232 1298 3166 1774 1841 285 1192 4327 1564 2222 1677 M13005 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 188/299 Gene Ontology BP GO:0051924 6.7874482704474e-09 1.17405192573947e-07 3580 2097.27272727273 1841 6.17040753762553e-10 191 2.27069874794076 2.31211788384084 1 18.9289077360334 3579 1665 191 455 910 2310 3982 4292 1841 280 3565 1678 M10344 GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. 18/23 Gene Ontology BP GO:0046337 2.83025400026001e-08 3.68884365916242e-07 625 1553.90909090909 1842 2.57295821515512e-09 53 1.92033536398913 -1.87011157084378 -1 14.837608195175 621 3006 2184 3398 53 355 175 1842 2799 2329 331 1679 M12230 GO_NEGATIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WOUND_HEALING.html Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 59/82 Gene Ontology BP GO:0061045 7.06240475958307e-08 4.02645553947883e-07 1845 1852 1843 6.42036816936298e-09 213 2.65385485265604 3.04742538186311 1 20.4224578393533 1843 352 237 1719 1947 2233 4418 1413 3564 213 2433 1680 M14200 GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS.html A multicellular organism process which involves another multicellular organism of the same or different species. 213/337 Gene Ontology BP GO:0044706 1.27010251636051e-08 2.05915923645485e-07 2460 2113.54545454545 1844 1.15463865790278e-09 203 2.41314156320363 2.30901774426925 1 19.410683708768 2459 1650 203 1275 1394 1844 3890 4388 2228 306 3612 1681 M10176 GO_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 268/308 Gene Ontology BP GO:0007059 3.52694823121813e-07 6.95966502114418e-07 20 1553.81818181818 1845 3.20631708785807e-08 18 1.64579344060428 1.83824638910751 1 12.1528665174811 18 3124 3368 2363 2302 180 173 810 1845 2130 779 1682 M16110 GO_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_PROLIFERATION.html The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. 37/52 Gene Ontology BP GO:0007405 6.55426519756183e-07 1.08222129042779e-06 860 1656.63636363636 1845 5.95842468201532e-08 20 2.03636467259289 2.63752803606328 1 14.5891736009974 859 2895 2114 3192 3380 562 1845 71 751 2534 20 1683 M10812 GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 187/272 Gene Ontology BP GO:0071216 2.17167173673272e-07 5.1420969993195e-07 1710 1847.18181818182 1846 1.97424722827597e-08 971 2.1738985998057 -2.27855453803094 -1 16.4311285376903 1709 2798 1065 1441 1893 2208 1896 1387 3105 971 1846 1684 M13680 GO_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTION.html Self-propelled movement of a cell or organism from one location to another. 1068/1674 Gene Ontology BP GO:0040011 4.78176407821978e-28 3.17850689370809e-25 1870 1776.81818181818 1847 4.78176407821977e-29 6 2.39334974639382 2.48939498239766 1 70.8061223819786 1868 1331 4443 278 423 1434 3728 1847 1868 6 2319 1685 M10733 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. 40/59 Gene Ontology BP GO:0050974 3.57837812222011e-05 3.96622043894478e-05 315 1878.36363636364 1848 3.25312393376033e-06 312 2.77079744975981 2.84476659160134 1 14.6468596869218 312 2512 467 1015 4209 1848 3069 2850 2442 626 1312 1686 M13785 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK.html The synchronization of a circadian rhythm to environmental time cues such as light. 44/73 Gene Ontology BP GO:0009649 3.94942937865936e-08 4.02645553947883e-07 2870 1921.81818181818 1848 3.5903904086903e-09 134 2.11501474129868 -1.87150742773147 -1 16.2549664494944 2867 521 1848 776 134 3888 3272 3767 244 2211 1612 1687 M15526 GO_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_DEVELOPMENT.html The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 151/190 Gene Ontology BP GO:0001890 8.98992750960911e-08 4.02645553947883e-07 1965 1815 1848 8.17266170633392e-09 880 2.13367250773266 -2.30603240545745 -1 16.3992691458392 1964 2811 1441 1168 880 2514 2149 1848 1644 2106 1440 1688 M10231 GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 10/16 Gene Ontology BP GO:0072216 2.13242564520751e-07 5.11188898874319e-07 4655 2211.36363636364 1849 1.93856895627293e-08 1084 2.91505460392651 1.99536874376289 1 22.0771823012516 4653 1230 1447 1084 1869 3962 3132 1849 2016 1611 1472 1689 M12411 GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. 15/17 Gene Ontology BP GO:0050655 1.07236976551019e-06 1.57554042277199e-06 260 1875.09090909091 1849 9.7488208020666e-08 257 2.47125463399207 2.6486886716199 1 17.2393515361738 257 2222 1849 4463 3131 466 277 1070 2959 2668 1264 1690 M10913 GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. 13/16 Gene Ontology BP GO:0033240 2.08619182743875e-07 5.04262367432337e-07 2340 1707.72727272727 1850 1.89653820478716e-08 171 2.03501506817973 2.47969855007676 1 15.3956974647543 2340 1146 2194 1403 1850 2450 2870 924 171 2775 662 1691 M16873 GO_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_FUSION.html A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 25/49 Gene Ontology BP GO:0007520 1.06761582650052e-06 1.56982208919024e-06 1700 2139.27272727273 1850 9.70560313266726e-08 824 2.80491932903333 3.46391590815193 1 19.5862381002455 1698 2584 824 3167 3128 1794 2824 876 3484 1303 1850 1692 M10811 GO_THYMIC_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMIC_T_CELL_SELECTION.html The process of T cell selection that occurs in the thymus. 16/27 Gene Ontology BP GO:0045061 1.3512534626995e-06 1.91280266563456e-06 1855 1829.18181818182 1851 1.22841299331669e-07 251 2.47226295033806 2.72016402705955 1 16.9945524220802 1851 3335 2214 2768 3256 1201 935 251 840 1991 1479 1693 M11525 GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. 36/41 Gene Ontology BP GO:1900026 2.19253376254584e-07 5.15766410370363e-07 1765 1851 1852 1.99321271005014e-08 656 2.06731848908113 -2.02627694220681 -1 15.6172267152078 1763 656 2193 1826 1910 2644 2601 1349 1852 2133 1434 1694 M12566 GO_EMBRYONIC_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_FORELIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 29/50 Gene Ontology BP GO:0035115 2.64051155494778e-07 5.72787891150211e-07 1650 1795.54545454545 1852 2.4004653380642e-08 756 2.41199113138545 2.53186078229204 1 18.1053216542008 1649 756 1205 1947 2084 1772 1852 2451 2953 2192 890 1695 M12631 GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of adherens junction organization. 94/107 Gene Ontology BP GO:1903391 1.01688643968987e-07 4.02645553947883e-07 1855 2180.18181818182 1853 9.24442260629550e-09 908 2.01041896880928 2.13526586915587 1 15.446002951645 1853 1842 1138 1021 1032 2030 3935 4096 3290 908 2837 1696 M12306 GO_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_ACTIVATION.html The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. 17/42 Gene Ontology BP GO:0045576 9.10774966738772e-07 1.39127902831106e-06 2445 1753.54545454545 1856 8.27977585263147e-08 344 2.02160139158935 -2.43192852910929 -1 14.2159220511899 2441 1021 1856 1188 3008 3016 1459 344 617 2180 2159 1697 M10968 GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 84/99 Gene Ontology BP GO:0061180 1.53998871345043e-07 4.40145422830765e-07 4080 2248.27272727273 1858 1.39998983749897e-08 207 2.33247485390327 2.34993351463372 1 17.8277510805639 4076 207 939 653 1534 3025 4210 1858 2551 1756 3922 1698 M10173 GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 16/20 Gene Ontology BP GO:0061000 2.93398755026689e-06 3.8006247414788e-06 1780 1915.81818181818 1859 2.66726496648189e-07 249 1.79242655068627 1.74409187257563 1 11.6465935559225 1780 1027 2324 1542 3567 1202 249 2390 1859 2408 2726 1699 M12586 GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 11/20 Gene Ontology BP GO:0022010 2.43744761706496e-08 3.39987841817087e-07 2785 2034.72727272727 1859 2.21586149460926e-09 9 4.76436569737473 5.90962275184653 1 37.168822684729 2783 1189 775 471 2992 3303 4251 9 164 1859 4586 1700 M15943 GO_REGULATION_OF_CELL_SHAPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SHAPE.html Any process that modulates the surface configuration of a cell. 174/204 Gene Ontology BP GO:0008360 2.11091503030531e-07 5.08389629193095e-07 2295 2044.18181818182 1859 1.91901384804461e-08 798 2.09693923630019 2.29565670942391 1 15.8583334649953 2291 1711 827 1271 1859 2779 4351 2546 1469 798 2584 1701 M15467 GO_NEGATIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSSIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation. 71/94 Gene Ontology BP GO:0030279 9.16819081726964e-08 4.02645553947883e-07 3785 2363.36363636364 1860 8.33471927212828e-09 597 1.95447687864713 1.98295146802789 1 15.0133362400036 3782 1860 1255 1210 904 3272 4562 1268 2979 597 4308 1702 M12986 GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM.html The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 11/20 Gene Ontology BP GO:0032291 1.04481678651859e-08 1.73008274294342e-07 2785 2035.27272727273 1861 9.49833446800548e-10 4 4.76436569737473 5.90962275184653 1 38.8593766788514 2784 1190 776 472 2993 3304 4252 4 165 1861 4587 1703 M13075 GO_SOMITOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITOGENESIS.html The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 70/100 Gene Ontology BP GO:0001756 1.48421364498612e-07 4.36901586057683e-07 2750 2096.36363636364 1863 1.34928522283409e-08 791 2.15262705979522 2.87748786811254 1 16.4535494751929 2748 1863 1364 791 1481 2356 3857 3192 1762 1647 1999 1704 M13270 GO_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of chemokine production. 76/124 Gene Ontology BP GO:0032642 1.1131315570564e-07 4.02645553947883e-07 4080 2166.72727272727 1865 1.01193783034308e-08 804 2.52450525017197 -2.83468793473674 -1 19.4220435359784 4079 1865 804 968 1166 4083 3990 971 2258 1344 2306 1705 M13979 GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 173/208 Gene Ontology BP GO:0090090 2.17156741736734e-07 5.1420969993195e-07 1305 1876.36363636364 1865 1.97415239247054e-08 1090 1.84403226342414 2.25399687388674 1 13.9222541652235 1301 2801 2286 1865 1892 1090 1438 1397 1432 2976 2162 1706 M14475 GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 11/15 Gene Ontology BP GO:0009312 6.82640149241808e-07 1.11016340950201e-06 2875 1981.18181818182 1866 6.20582146417254e-08 20 3.27101396558396 -2.47903410959852 -1 23.4532271781853 2874 1169 1186 1258 2816 2978 2007 1743 20 1866 3876 1707 M11556 GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. 10/20 Gene Ontology BP GO:2000846 1.35746491766299e-06 1.91867687177579e-06 625 1749.81818181818 1867 1.23405977750875e-07 188 2.27265564156704 -2.13149514714425 -1 15.610461430763 622 2737 1867 2509 3262 726 188 410 3370 2147 1410 1708 M14844 GO_STEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 11/19 Gene Ontology BP GO:0016127 4.3147523662357e-07 8.03061710403788e-07 2265 1871.90909090909 1868 3.92250292042473e-08 1027 2.75080915853021 -2.63026224394874 -1 20.1748532315116 2265 2241 1353 1066 2450 1990 1027 1678 1528 1868 3125 1709 M14040 GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. 26/27 Gene Ontology BP GO:0016242 5.53073116613829e-07 9.52776457461735e-07 1545 2053.27272727273 1869 5.02793868777027e-08 765 1.30473702756353 -0.903603735935148 -1 9.39786618918156 1545 829 3036 2317 2658 1725 1869 765 3536 3120 1186 1710 M14078 GO_CELLULAR_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 65/74 Gene Ontology BP GO:0031670 2.23050567808197e-09 4.32439288338142e-08 1610 1881.45454545455 1869 2.02773243667582e-10 170 3.05872713292161 3.16584511954894 1 27.1383491544497 1608 1869 170 898 3251 2788 3799 2794 862 451 2206 1711 M11754 GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. 52/91 Gene Ontology BP GO:1904063 6.96846047981679e-08 4.02645553947883e-07 4165 2431.18181818182 1870 6.33496427321957e-09 384 1.89638596482475 1.74326839829397 1 14.5640501195365 4163 384 1870 1602 568 4611 2853 3524 1352 1506 4310 1712 M15450 GO_CHOLESTEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 11/19 Gene Ontology BP GO:0006707 4.3147523662357e-07 8.03061710403788e-07 2270 1878.54545454545 1870 3.92250292042473e-08 1028 2.75080915853021 -2.63026224394874 -1 20.1748532315116 2266 2242 1354 1067 2451 1991 1028 1740 1529 1870 3126 1713 M16787 GO_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). 92/155 Gene Ontology BP GO:0003014 7.47159108856032e-08 4.02645553947883e-07 4385 2277.18181818182 1870 6.7923557657353e-09 131 2.41505098754841 -2.55290331944295 -1 18.5755035560241 4384 131 572 1268 645 3679 3115 4214 1870 818 4353 1714 M13039 GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. 123/171 Gene Ontology BP GO:0071774 1.79799080676657e-07 4.72066258868601e-07 585 1923.36363636364 1871 1.63453723064611e-08 584 1.94874648217782 2.37623316758959 1 14.8062077932101 584 3157 1511 2801 1689 831 2098 1871 3008 2956 651 1715 M16365 GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 39/62 Gene Ontology BP GO:0021680 5.84735165504524e-08 4.02645553947883e-07 2620 1650.90909090909 1871 5.31577437314659e-09 156 2.82107879996055 3.42884390653198 1 21.7157994928064 2617 593 1032 156 386 2834 2688 2196 1871 1947 1840 1716 M16839 GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-12 production. 64/124 Gene Ontology BP GO:0032655 5.37644181000016e-07 9.33644492378785e-07 570 2011 1871 4.88767556719587e-08 566 1.4759412475284 -1.5844775834406 -1 10.6602646658002 566 1877 2540 2985 2631 1293 1832 1546 4082 898 1871 1717 M15321 GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. 61/68 Gene Ontology BP GO:2001244 6.04181288019458e-08 4.02645553947883e-07 2140 1662.09090909091 1872 5.49255731465417e-09 374 2.53009168785582 -2.15939285417431 -1 19.4652501021874 2140 2467 1750 969 409 2245 1264 2205 374 2588 1872 1718 M16623 GO_COPULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPULATION.html The act of sexual union between male and female, involving the transfer of sperm. 11/20 Gene Ontology BP GO:0007620 5.81234628681308e-07 9.9138003198465e-07 1615 2001.36363636364 1872 5.28395256583758e-08 238 3.22516101557599 3.61866842033141 1 23.314714391914 1614 2268 1221 3147 2686 2173 3818 1270 1708 1872 238 1719 M12024 GO_SOMATIC_CELL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_CELL_DNA_RECOMBINATION.html Recombination occurring within or between DNA molecules in somatic cells. 30/36 Gene Ontology BP GO:0016444 1.49243398472701e-06 2.08349694897532e-06 740 2186.81818181818 1873 1.35675908833088e-07 524 1.42418498770056 1.60640880375178 1 9.68238482990074 739 3516 3402 3252 3300 1014 524 830 1553 4052 1873 1720 M12748 GO_REGULATION_OF_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 304/457 Gene Ontology BP GO:0090087 5.54147812517952e-08 4.02645553947883e-07 4270 2352.90909090909 1874 5.03770751341933e-09 131 2.17840005088173 2.26469767498975 1 16.7452004286714 4607 1558 464 131 337 4270 3979 3992 1874 404 4266 1721 M14068 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS.html The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. 30/36 Gene Ontology BP GO:0002562 1.49243398472701e-06 2.08349694897532e-06 740 2182.27272727273 1874 1.35675908833088e-07 525 1.42418498770056 1.60640880375178 1 9.68238482990074 740 3517 3403 3253 3301 1015 525 770 1554 4053 1874 1722 M16185 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 9/23 Gene Ontology BP GO:0032700 4.54230547655372e-07 8.29813403313878e-07 2115 2046.36363636364 1874 4.54230640501824e-08 849 2.06928797479353 -2.20278806311244 -1 15.1153492992025 2111 1257 4601 1012 2575 1874 849 1955 1261 3524 1491 1723 M10453 GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. 68/140 Gene Ontology BP GO:0046634 1.89355187988088e-06 2.56946541180686e-06 250 2009.63636363636 1876 1.72141228152107e-07 249 1.66319303344458 -1.57138004301527 -1 11.1414267485738 249 1876 2790 2578 3398 935 1286 1764 3637 1890 1703 1724 M11335 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. 27/45 Gene Ontology BP GO:0002475 5.14880462338579e-06 6.3835299527349e-06 160 1930.90909090909 1876 4.68074243046473e-07 159 1.37731077496594 -1.08495925554743 -1 8.55033532787574 159 751 2766 2446 3729 819 923 1876 3527 2553 1691 1725 M12654 GO_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. 141/246 Gene Ontology BP GO:0048469 1.28944474713475e-07 4.18245386187413e-07 3840 2484.81818181818 1876 1.17222256610051e-08 535 2.01174502087979 2.211348643216 1 15.4160943300926 3839 1772 637 747 1328 3396 4455 4473 1876 535 4275 1726 M13732 GO_CELLULAR_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 26/40 Gene Ontology BP GO:0071361 2.14499963873285e-07 5.12148364863292e-07 3180 1702 1876 1.94999986170028e-08 152 2.74409193960605 -2.4792883394988 -1 20.7736546521076 3180 766 808 152 1876 3368 2786 2148 748 952 1938 1727 M13800 GO_MAINTENANCE_OF_CELL_NUMBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_NUMBER.html Any process by which the numbers of cells of a particular type in a tissue are maintained. 162/209 Gene Ontology BP GO:0098727 1.50076020999628e-07 4.37259690489211e-07 2145 1921.36363636364 1877 1.36432755670246e-08 813 1.99664035729723 2.13897706787139 1 15.2529492457853 2141 1759 1877 813 1502 1398 2147 3141 1616 2699 2042 1728 M14294 GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. 67/211 Gene Ontology BP GO:0050830 2.16116057686424e-06 2.88713183007445e-06 705 2134.09090909091 1877 1.96469336352181e-07 702 1.94577372603334 -1.93048568328756 -1 12.9327473479691 702 1887 1715 3450 3452 987 1025 2909 3914 1557 1877 1729 M16457 GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. 29/43 Gene Ontology BP GO:0007212 5.95922676159593e-08 4.02645553947883e-07 3755 2256.54545454545 1877 5.41747902092352e-09 398 2.10985307574588 -1.74641941404303 -1 16.2150451513297 3751 727 1422 1336 398 4578 2900 4201 1039 1877 2593 1730 M13812 GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. 21/36 Gene Ontology BP GO:0002437 6.74399725386625e-07 1.09911801128685e-06 3770 2385.72727272727 1878 6.13090847382545e-08 641 2.20464024761475 1.83409689265358 1 15.7853226236816 3770 922 1313 1622 2809 3300 4308 1702 1878 641 3978 1731 M12045 GO_LIPID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. 105/179 Gene Ontology BP GO:0055088 4.78417062801457e-07 8.57832213185041e-07 1775 1764.36363636364 1879 4.34924697126513e-08 543 2.10105246389238 -1.6821517880994 -1 15.3123109030974 1774 2407 1879 1980 2546 1378 1343 2227 2099 1232 543 1732 M13793 GO_REGULATION_OF_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION.html Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. 28/63 Gene Ontology BP GO:0051931 6.79911836634526e-08 4.02645553947883e-07 3380 2179.27272727273 1879 6.18101688770235e-09 533 2.84250065610799 2.39540731063708 1 21.8814801820639 3380 2930 797 1817 533 3596 4537 627 1879 1410 2466 1733 M12807 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. 65/94 Gene Ontology BP GO:1904427 4.55472268711703e-07 8.3153068251175e-07 1880 1738.09090909091 1880 4.14065784554047e-08 433 2.43996216956643 2.54390227153422 1 17.8387746620256 1880 2457 1080 2212 2498 930 1982 1826 2405 1416 433 1734 M16918 GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN.html Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. 28/63 Gene Ontology BP GO:0051930 6.79911836634526e-08 4.02645553947883e-07 3385 2170 1880 6.18101688770235e-09 511 2.84250065610799 2.39540731063708 1 21.8814801820639 3381 2931 798 1818 534 3597 4538 511 1880 1415 2467 1735 M10135 GO_METANEPHRIC_NEPHRON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. 16/29 Gene Ontology BP GO:0072273 2.66102886947572e-07 5.75360935393612e-07 2165 1751.90909090909 1882 2.41911744667528e-08 195 2.07529354988287 2.23940443473634 1 15.5586839586664 2162 976 1264 195 2092 1882 4044 2963 1940 333 1420 1736 M12574 GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. 38/49 Gene Ontology BP GO:0036296 3.95465925862058e-05 4.366642033783e-05 505 2171.18181818182 1882 3.59520940752054e-06 502 2.35244401572569 2.60665623473057 1 12.3009946923976 502 2896 1301 1882 4180 1739 2312 3131 3275 1097 1568 1737 M15622 GO_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEEDING_BEHAVIOR.html Behavior associated with the intake of food. 58/131 Gene Ontology BP GO:0007631 1.48620449483795e-07 4.36901586057683e-07 4150 2119.18181818182 1882 1.35109508658012e-08 379 2.59253705642191 3.00074540525871 1 19.8370306156546 4148 379 806 1098 1483 4170 2791 2393 1194 1882 2967 1738 M15782 GO_RESPONSE_TO_HYPEROXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYPEROXIA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. 38/49 Gene Ontology BP GO:0055093 3.95465925862058e-05 4.366642033783e-05 505 2172.54545454545 1883 3.59520940752054e-06 503 2.35244401572569 2.60665623473057 1 12.3009946923976 503 2897 1302 1883 4181 1740 2313 3132 3276 1102 1569 1739 M11398 GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of T cell proliferation. 77/158 Gene Ontology BP GO:0042102 3.57882026865902e-07 7.01738335864745e-07 1045 1852.63636363636 1884 3.25347350076264e-08 216 1.80215460563011 -1.56856507310656 -1 13.3094325152833 1041 216 1464 2434 2317 1515 2248 2880 3802 578 1884 1740 M12324 GO_ANATOMICAL_STRUCTURE_REGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_REGRESSION.html The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. 15/20 Gene Ontology BP GO:0060033 4.88957821303178e-07 8.7035988619881e-07 410 1699.45454545455 1885 4.44507209068932e-08 117 2.00869347676945 2.17228104390285 1 14.6193835700615 409 3350 2602 1885 2568 274 141 1880 2801 2667 117 1741 M16579 GO_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that modulates the frequency, rate or extent of lymphocyte migration. 32/59 Gene Ontology BP GO:2000401 2.16377739133596e-07 5.13962042198191e-07 3035 2097.81818181818 1886 1.96707054922828e-08 655 3.0024251817621 -2.787850601937 -1 22.7334379228218 3033 698 655 926 1886 3224 2430 3453 1745 1145 3881 1742 M13496 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune system process. 1253/2113 Gene Ontology BP GO:0002682 8.56007364524627e-08 4.02645553947883e-07 1890 1953.36363636364 1887 8.56007397498316e-09 212 2.08414219522628 -2.01988002181403 -1 16.0161923359347 1887 1326 4430 677 931 1904 1772 3572 2837 212 1939 1743 M10887 GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. 202/261 Gene Ontology BP GO:0032104 9.13668800936319e-08 4.02645553947883e-07 900 1893.45454545455 1888 8.30608035346686e-09 33 1.38271001670691 -1.38940365007939 -1 10.5911831301691 899 2371 3912 2619 899 150 1392 1888 2477 4188 33 1744 M12822 GO_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 209/316 Gene Ontology BP GO:1901654 8.22591385102301e-08 4.02645553947883e-07 4200 2380.18181818182 1888 7.47810378054019e-09 400 2.27872234438359 2.32843827777232 1 17.5211120313298 4200 1659 400 715 772 4162 3812 3676 1888 880 4018 1745 M11669 GO_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. 1236/1788 Gene Ontology BP GO:0016192 6.99426985205572e-08 4.02645553947883e-07 1865 2062.72727272727 1889 6.99427007219487e-09 683 1.88256679273168 -1.67961423644337 -1 14.4571700274666 1864 1330 4319 1889 683 1214 1445 3303 1980 2426 2237 1746 M11713 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 137/200 Gene Ontology BP GO:0034764 1.39665064262043e-08 2.24090187590099e-07 2280 1951.90909090909 1889 1.26968241044268e-09 205 2.62493021630726 2.64703295344508 1 21.006680976326 2280 1782 205 1704 1889 1356 2894 4231 2362 447 2321 1747 M15818 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. 41/61 Gene Ontology BP GO:1901016 1.77132081075161e-07 4.6864496475983e-07 4535 2346.27272727273 1889 1.6102917757898e-08 533 2.33261539176594 -1.91271206755323 -1 17.7519639041959 4535 533 1295 947 1677 3740 2881 3839 715 1889 3758 1748 M10422 GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. 30/70 Gene Ontology BP GO:0002820 3.32723227811372e-07 6.71071165585746e-07 1100 2066.09090909091 1891 3.02475707392475e-08 514 2.14010413510143 -2.26857323636943 -1 15.8748235617889 1099 2562 1891 3430 2252 1825 1239 514 3776 2948 1191 1749 M11678 GO_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a leukocyte. 147/448 Gene Ontology BP GO:0002443 1.22743467400051e-07 4.14338946095474e-07 2390 1818.72727272727 1891 1.11584976589286e-08 1133 2.09881725632983 -2.07287776626687 -1 16.0981336847969 1807 2388 1133 2388 1261 1891 1473 2110 2124 2176 1255 1750 M14283 GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. 16/40 Gene Ontology BP GO:0042537 2.20118356840454e-07 5.17017018868568e-07 2530 1947.27272727273 1892 2.00107617149214e-08 1052 2.7348247101705 2.57107954131723 1 20.6895604168139 2526 1052 1235 2390 1913 1892 1529 2055 1833 1545 3450 1751 M12510 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. 134/170 Gene Ontology BP GO:0033135 3.50259799193559e-08 3.99952679980378e-07 3535 2297.63636363636 1893 3.18418004336372e-09 100 2.11403856231959 2.14762906870593 1 16.2548675156918 3535 1792 863 932 100 2837 3703 4380 608 1893 4631 1752 M12857 GO_POSITIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_GROWTH.html Any process that activates or increases the frequency, rate, extent or direction of cell growth. 174/233 Gene Ontology BP GO:0030307 4.84202192677283e-08 4.02645553947883e-07 4025 2441.72727272727 1893 4.40183821212893e-09 226 2.14097942776806 2.1746803191361 1 16.4557822481345 4022 1721 927 1299 226 3372 3868 4321 1893 1231 3979 1753 M15536 GO_MYELIN_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_MAINTENANCE.html The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. 12/14 Gene Ontology BP GO:0043217 6.20721954097643e-08 4.02645553947883e-07 4380 2032.18181818182 1893 5.64292701464626e-09 391 2.20531201877391 -2.4886021493636 -1 16.9533426810964 4376 1171 1893 591 436 4092 3874 2067 391 2089 1374 1754 M13454 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. 155/259 Gene Ontology BP GO:0031348 2.17195542860278e-07 5.1420969993195e-07 1330 2265 1894 1.97450513002695e-08 1155 1.9051894894895 -1.57953453000775 -1 14.3873995294023 1326 2383 1423 2969 1894 1397 1434 4578 3804 1155 2552 1755 M13637 GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. 107/218 Gene Ontology BP GO:0002706 6.60514965734313e-07 1.08599863447412e-06 1265 1790.63636363636 1894 6.00468330948633e-08 83 1.77507673781669 -1.5454875510322 -1 12.7007634001321 1263 83 1894 2428 2785 1303 1932 2438 3808 1088 675 1756 M14851 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell migration. 130/152 Gene Ontology BP GO:0010634 1.10642126441471e-07 4.02645553947883e-07 4370 2173 1896 1.00583756368974e-08 3 2.16367363798043 1.90621642608956 1 16.6313035645069 4370 3 951 560 1156 4098 4514 2179 1896 843 3333 1757 M14534 GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. 99/110 Gene Ontology BP GO:0031023 2.21772660007058e-07 5.17979430590306e-07 595 1893.27272727273 1897 2.01611529420929e-08 339 1.43317921021435 1.40283630064009 1 10.7919182650958 592 2412 3678 2944 1923 524 339 1780 1748 2989 1897 1758 M10898 GO_OTIC_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OTIC_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. 29/42 Gene Ontology BP GO:0071599 5.9793710540737e-05 6.50350947045464e-05 225 1827.09090909091 1899 5.43593961212766e-06 224 2.89389871724854 3.27082610235139 1 14.5504949958695 224 2023 497 1024 4248 1724 2752 2770 2254 683 1899 1759 M12662 GO_NEURAL_NUCLEUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_NUCLEUS_DEVELOPMENT.html The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. 100/153 Gene Ontology BP GO:0048857 5.74222895577574e-07 9.83385768539733e-07 2025 1948.90909090909 1899 5.22020950414347e-08 286 2.24232653862633 2.50183392037011 1 16.1879564759691 2022 3446 1899 1318 2674 1485 2356 713 1747 3492 286 1760 M15265 GO_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. 142/251 Gene Ontology BP GO:0034341 1.24319831716472e-06 1.78207078551061e-06 235 2044.81818181818 1899 1.13018092698581e-07 233 1.98819071948147 -1.97391322931968 -1 13.7207654319992 233 3146 1415 3440 3206 1196 1085 1899 3836 928 2109 1761 M13891 GO_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 53/61 Gene Ontology BP GO:0071616 9.3139992729908e-07 1.41641080841956e-06 335 2019.27272727273 1900 8.46727565109221e-08 334 1.55830794535643 -1.49464800626259 -1 10.919789857826 334 2484 3120 3197 3022 874 472 1446 1741 3622 1900 1762 M15448 GO_THIOESTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 53/61 Gene Ontology BP GO:0035384 9.3139992729908e-07 1.41641080841956e-06 335 2017.27272727273 1901 8.46727565109221e-08 335 1.55830794535643 -1.49464800626259 -1 10.919789857826 335 2485 3121 3198 3023 875 473 1414 1742 3623 1901 1763 M16781 GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 313/463 Gene Ontology BP GO:0060249 2.18090074072014e-07 5.15113256171106e-07 1300 1931.27272727273 1901 1.98263723356082e-08 431 2.05615407460336 2.08152047772246 1 15.5336994221161 1299 3414 929 2857 1901 431 1769 2312 3410 1929 993 1764 M12446 GO_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that modulates the activity of a transporter. 198/288 Gene Ontology BP GO:0032409 5.53071430292737e-08 4.02645553947883e-07 3440 2026.18181818182 1905 5.02792221997032e-09 238 2.37095674536161 2.69197677860796 1 18.2344703426782 3439 1646 238 876 334 2507 4057 4373 1905 287 2626 1765 M15707 GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. 49/60 Gene Ontology BP GO:0045668 7.14678837264485e-08 4.02645553947883e-07 4200 2437.54545454545 1905 6.49708054982831e-09 592 2.01267543034406 -1.79645412018793 -1 15.4634548521616 4198 1905 1494 1214 592 3715 4221 1319 2823 1459 3873 1766 M16470 GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 33/42 Gene Ontology BP GO:0090314 1.83436250958257e-06 2.49642841681418e-06 1905 1999.27272727273 1905 1.667603671889e-07 536 1.62813913958618 -1.99097242185308 -1 10.9290970664759 1905 2917 3140 2139 3389 1482 737 1240 639 3868 536 1767 M10108 GO_MULTICELLULAR_ORGANISM_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_AGING.html An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). 30/39 Gene Ontology BP GO:0010259 2.18917382863398e-07 5.15590364235942e-07 1845 2046.54545454545 1906 1.99015822406737e-08 545 2.32555481363698 2.39429638016035 1 17.5813095338808 1842 3247 1946 3235 1906 1773 1755 2113 545 2947 1203 1768 M13717 GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 9/34 Gene Ontology BP GO:0002323 1.1543682062678e-06 1.67225257277835e-06 1600 1988.54545454545 1908 1.15436880592291e-07 69 2.0158771571118 -1.92273712006807 -1 13.9806118759077 1598 1244 4446 1991 3223 1550 461 1908 69 2459 2925 1769 M16550 GO_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PROCESS.html The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. 1201/1538 Gene Ontology BP GO:0022402 1.99153502731856e-07 4.93878508235586e-07 345 2056.81818181818 1908 1.99153520579811e-08 344 1.58520176078 1.7395406455371 1 11.98724771672 344 2762 4634 3391 1908 410 624 1441 2469 3321 1321 1770 M12778 GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT.html The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. 448/630 Gene Ontology BP GO:0061458 9.26567764841812e-08 4.02645553947883e-07 3775 2201.54545454545 1909 8.42334367150733e-09 570 2.11704038047305 2.07108246442482 1 16.2706331261954 3775 1491 570 771 914 2591 3676 3866 1909 969 3685 1771 M16728 GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. 326/481 Gene Ontology BP GO:0002237 9.08252346242687e-08 4.02645553947883e-07 1580 1704.72727272727 1909 8.2568398521742e-09 383 2.11572728602381 -2.26003273266835 -1 16.2604774052386 1578 1545 465 1956 891 1909 1969 2053 3486 383 2517 1772 M10218 GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of leukocyte proliferation. 192/335 Gene Ontology BP GO:0070663 1.35805290122699e-07 4.23886744058351e-07 1910 1879.54545454545 1910 1.23459362278105e-08 331 2.02686443228893 -1.96290964027385 -1 15.5184656281024 1910 1680 536 1145 1388 1983 2450 3610 3392 331 2250 1773 M13139 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET.html The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. 83/92 Gene Ontology BP GO:0002011 2.19499667794058e-07 5.16084868239388e-07 2065 1712.54545454545 1911 1.99545172449189e-08 172 2.59138462036498 2.69076916052092 1 19.6014601530803 2063 172 284 548 1911 2351 4159 3967 845 317 2221 1774 M13253 GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT.html The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. 128/205 Gene Ontology BP GO:0060538 7.51996421484482e-08 4.02645553947883e-07 3120 1988.36363636364 1911 6.83633133808151e-09 6 2.25692881252703 2.49325483304835 1 17.3525567318031 3118 6 543 1911 651 3090 4611 3122 1551 560 2709 1775 M13992 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 19/23 Gene Ontology BP GO:0009147 1.96212440560618e-07 4.93246485651519e-07 1470 2221.63636363636 1911 1.78374961873011e-08 1470 1.15289544979265 1.18322903600416 1 8.69085788986571 1470 2131 3380 2493 1771 1911 1651 1716 1526 3572 2817 1776 M11354 GO_HYPEROSMOTIC_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPEROSMOTIC_RESPONSE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. 22/43 Gene Ontology BP GO:0006972 1.9193471655991e-08 2.89958518231579e-07 3100 2194.09090909091 1915 1.74486107485825e-09 13 1.87058071185123 -1.72507224678803 -1 14.6870385456881 3100 870 1797 1134 13 2614 2562 4570 1915 1841 3719 1777 M15858 GO_TRYPTOPHAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRYPTOPHAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. 7/13 Gene Ontology BP GO:0006568 5.04459528858363e-07 8.90459100067512e-07 590 1904.09090909091 1915 5.04459643374136e-08 487 2.65778231902325 -2.65778231902325 -1 19.3448879792328 590 3396 4577 2430 2660 691 487 857 2820 1915 522 1778 M13574 GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 73/111 Gene Ontology BP GO:0051588 2.17697883401158e-07 5.14458239001953e-07 4135 2334.72727272727 1918 1.97907186311951e-08 267 2.02149695912458 2.19927272043801 1 15.271489700166 4132 267 1599 1383 1899 4548 3192 1918 2991 895 2858 1779 M13912 GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. 15/21 Gene Ontology BP GO:0002921 1.08811239535099e-06 1.59113355611822e-06 1580 2310.36363636364 1918 9.89193575934538e-08 199 2.71633986472023 -2.74020222233649 -1 18.9452141083704 1576 4050 1918 3413 3148 1866 727 1742 3642 3133 199 1780 M11148 GO_OXIDATIVE_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. 9/41 Gene Ontology BP GO:0070989 1.82706962369732e-06 2.4879587237529e-06 1530 2469.18181818182 1919 1.8270711258816e-07 984 2.6615554188938 -3.21457804321794 -1 17.9361396024852 1530 3605 4280 3894 3419 1489 1365 984 1919 3520 1156 1781 M16224 GO_TRANSCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCYTOSIS.html The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. 11/12 Gene Ontology BP GO:0045056 1.56337045323456e-07 4.41807401483567e-07 2740 1846 1920 1.42124596757387e-08 540 2.93252728942261 -3.53494326973597 -1 22.4347998478269 2739 2276 1403 749 1557 2991 2541 1201 540 2389 1920 1782 M16394 GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. 15/24 Gene Ontology BP GO:0030826 7.72963428524199e-08 4.02645553947883e-07 3525 2135.36363636364 1920 7.02694050620036e-09 692 2.48387835813564 2.3455406360344 1 19.1078274648481 3523 1063 986 725 692 2975 3766 1920 2870 785 4184 1783 M16815 GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. 48/91 Gene Ontology BP GO:0045671 8.23412555978973e-06 9.83655615653444e-06 1370 2223.27272727273 1920 7.48559670773405e-07 1275 2.30088392118674 -2.31436131388936 -1 13.8303721447261 1369 3210 1920 2306 3869 2178 1400 1275 1761 3531 1637 1784 M15367 GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. 22/33 Gene Ontology BP GO:0006658 7.01161778895593e-07 1.13307489517219e-06 30 1432.54545454545 1921 6.37420002148084e-08 26 2.15272194263072 -2.26732351356483 -1 15.3767572704304 38 2974 1989 1921 2835 30 26 82 3001 2584 278 1785 M15494 GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 64/90 Gene Ontology BP GO:0046889 2.14282866165304e-07 5.12148364863292e-07 2385 1753.36363636364 1921 1.94802624578852e-08 247 2.02543428974572 -1.89984523242248 -1 15.3062222294477 2384 339 2084 247 1874 2418 2951 2035 1522 1512 1921 1786 M14600 GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS.html Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. 47/64 Gene Ontology BP GO:0097006 1.97860898635682e-07 4.93246485651519e-07 1485 2324.45454545455 1923 1.79873560391505e-08 1201 2.46455560778185 3.08486225426431 1 18.6956659392272 2705 1923 1201 1785 1787 3815 4356 2433 1485 1482 2597 1787 M15978 GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. 20/24 Gene Ontology BP GO:0010640 2.2181112220458e-07 5.17979430590306e-07 1925 2612.54545454545 1924 2.01646495062089e-08 787 2.94731847404989 2.91365649678561 1 22.3022440541727 3598 3770 1827 1202 1924 3857 4593 880 787 1921 4379 1788 M10626 GO_RESPONSE_TO_IMMOBILIZATION_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IMMOBILIZATION_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. 17/28 Gene Ontology BP GO:0035902 1.4111529431888e-06 1.98548998019398e-06 1200 1923.81818181818 1926 1.28286713486354e-07 63 2.71435104274071 -2.01869792897116 -1 18.6155969022068 1198 2671 1481 3677 3277 1341 63 1926 2116 2591 821 1789 M10393 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM.html A process in which an organism has a negative effect on the functioning of the second organism's cells. 10/82 Gene Ontology BP GO:0044364 2.22197924663282e-07 5.17979430590306e-07 85 1670.36363636364 1927 2.01998133731878e-08 81 3.44190678190339 -3.61023298486631 -1 26.0620518148151 2415 1234 1336 81 1927 2681 2122 1688 85 2139 2666 1790 M11320 GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM.html Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 10/82 Gene Ontology BP GO:0031640 2.22197924663282e-07 5.17979430590306e-07 2420 1671.09090909091 1928 2.01998133731878e-08 82 3.44190678190339 -3.61023298486631 -1 26.0620518148151 2416 1235 1337 82 1928 2682 2123 1680 86 2146 2667 1791 M15770 GO_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_KILLING.html Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 42/141 Gene Ontology BP GO:0001906 3.53393522507979e-07 6.96609636984353e-07 1930 1776.63636363636 1928 3.2126689024982e-08 464 2.05232726161099 -1.87087353790357 -1 15.1792295518205 1928 1944 1786 714 2304 1703 1715 3060 464 1989 1936 1792 M16274 GO_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 51/68 Gene Ontology BP GO:0051489 2.46492455875433e-07 5.55178890213083e-07 2390 1757.81818181818 1928 2.24084075902683e-08 455 2.34568606847581 2.79093788260815 1 17.6432507970874 2387 455 1329 1110 2002 2973 3060 934 535 1928 2623 1793 M14609 GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 26/29 Gene Ontology BP GO:0010888 1.87847438745124e-06 2.55198286855785e-06 1460 2072.45454545455 1929 1.70770544672024e-07 767 2.66418100748405 -2.17830151771884 -1 17.9183809110182 1456 3261 1907 2291 3394 2057 1929 767 2994 1763 978 1794 M16043 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 77/151 Gene Ontology BP GO:0032729 7.29587701245595e-07 1.16700451189321e-06 1105 1806.27272727273 1929 6.63261766544947e-08 158 1.83124450677495 -1.87447007964672 -1 13.0367099416409 1104 3184 1929 2089 2865 1683 1955 158 2476 1418 1008 1795 M13197 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 71/84 Gene Ontology BP GO:2001239 8.21671435015583e-07 1.28382712798103e-06 520 1901.54545454545 1930 7.46974310817595e-08 418 2.30880131712507 2.44967520171872 1 16.3476129612677 517 3462 1149 2346 2935 628 1930 2658 3384 1490 418 1796 M15789 GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cell differentiation. 910/1237 Gene Ontology BP GO:0045597 6.00935736595069e-19 5.4826548674056e-17 2365 1864.54545454545 1931 6.00935736595069e-20 27 2.18932678890547 2.38263826933545 1 42.9523891897149 2365 1356 4572 353 478 1493 3592 1931 1986 27 2357 1797 M10225 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. 27/34 Gene Ontology BP GO:2000678 9.17695048001865e-05 9.86379084858554e-05 375 1807.72727272727 1932 8.34303027662264e-06 372 1.92387410233366 -1.8260044576847 -1 9.21781343466644 372 2058 1949 2970 4304 881 687 807 3483 1932 442 1798 M12245 GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myeloid cell differentiation. 188/290 Gene Ontology BP GO:0045637 9.25733501358029e-08 4.02645553947883e-07 1465 1937.63636363636 1933 8.41575945737985e-09 912 2.22247352169937 -2.47909173477379 -1 17.0860729923175 1462 3136 1110 2438 912 1933 1668 1150 3027 2364 2114 1799 M13280 GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 586/759 Gene Ontology BP GO:0010563 7.78577570478642e-08 4.02645553947883e-07 3205 2330 1933 7.7857759775688e-09 824 2.01880903905135 2.30203418894375 1 15.510893342611 3202 2330 4417 1312 824 1491 4095 3285 1933 1607 1134 1800 M14196 GO_SEGMENT_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENT_SPECIFICATION.html The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. 19/24 Gene Ontology BP GO:0007379 5.52430063646432e-08 4.02645553947883e-07 995 2030.45454545455 1934 5.02209161380186e-09 333 2.10151786631153 -1.31015359292409 -1 16.1505790642323 3003 994 1934 3857 333 2660 993 3538 1227 1726 2070 1801 M15999 GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 586/759 Gene Ontology BP GO:0045936 7.78577570478642e-08 4.02645553947883e-07 3205 2264.09090909091 1934 7.7857759775688e-09 825 2.01880903905135 2.30203418894375 1 15.510893342611 3203 2331 4584 1313 825 1492 4096 2384 1934 1608 1135 1802 M15464 GO_POSITIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_KILLING.html Any process that activates or increases the frequency, rate or extent of cell killing. 43/84 Gene Ontology BP GO:0031343 8.4460624959907e-07 1.30911155209343e-06 555 2047.36363636364 1936 7.67824158048782e-08 364 1.42708533158443 -1.21120881769305 -1 10.0506298877598 554 1936 2798 2559 2958 364 645 3262 4225 1824 1396 1803 M11041 GO_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane. 134/181 Gene Ontology BP GO:0061025 2.26141740378305e-07 5.25330762845858e-07 890 1958.63636363636 1937 2.05583421476184e-08 285 1.68230374996424 -1.53650526730771 -1 12.6732843029131 890 2396 3336 3878 1937 285 763 2504 1092 4003 461 1804 M12500 GO_LYMPHOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. 339/544 Gene Ontology BP GO:0046649 9.65872691651861e-08 4.02645553947883e-07 2820 1923.36363636364 1938 8.78066121869881e-09 132 2.0224490433599 -1.80707841662452 -1 15.5390458247577 2819 1530 435 132 963 3008 2636 4317 1938 288 3091 1805 M12534 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/43 Gene Ontology BP GO:0043267 8.42750474274103e-08 4.02645553947883e-07 2770 1810.36363636364 1939 7.66136824142922e-09 795 2.61686799262211 -2.47432940792805 -1 20.1363944645592 2768 855 974 2015 795 2487 1939 1729 3149 1187 2016 1806 M15948 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of lamellipodium organization. 40/46 Gene Ontology BP GO:1902745 1.17579498185955e-06 1.6974787622068e-06 2130 2122.18181818182 1939 1.06890510024211e-07 477 1.92526673407775 -2.02166714998277 -1 13.3324377131892 2126 3225 2784 1847 3186 1932 1511 477 1939 3550 767 1807 M10246 GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. 108/204 Gene Ontology BP GO:1900544 1.36011800747715e-07 4.23886744058351e-07 2455 2115.27272727273 1942 1.23647099233134e-08 96 2.06729379744653 2.21233909422993 1 15.830062310133 2455 96 1461 1184 1390 1942 4141 3640 3314 1123 2522 1808 M12389 GO_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE.html Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. 894/1049 Gene Ontology BP GO:0000278 2.39403730952565e-07 5.4578420388157e-07 245 1997.09090909091 1942 2.39403756743934e-08 245 1.58610418737849 1.76914889240309 1 11.9108776604869 245 2763 4366 3392 2079 484 568 1260 1942 3424 1445 1809 M15357 GO_GOLGI_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_VESICLE_TRANSPORT.html The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. 387/431 Gene Ontology BP GO:0048193 9.35665992535045e-08 4.02645553947883e-07 1620 2445.63636363636 1942 8.50605483935614e-09 923 1.62984998256894 -1.42663253569243 -1 12.5026103942337 1617 3629 3954 3015 923 1377 1555 3368 1093 4429 1942 1810 M13998 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 108/204 Gene Ontology BP GO:0045981 1.36011800747715e-07 4.23886744058351e-07 2460 2125.27272727273 1943 1.23647099233134e-08 97 2.06729379744653 2.21233909422993 1 15.830062310133 2456 97 1462 1185 1391 1943 4142 3738 3315 1126 2523 1811 M10211 GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. 12/14 Gene Ontology BP GO:0008608 8.75267914560964e-07 1.34587627443892e-06 790 1756.36363636364 1944 7.95698420714245e-08 176 2.52308858147046 2.33523815199121 1 17.8118935250297 786 3058 2070 1944 2984 1328 1082 1965 176 2078 1849 1812 M11703 GO_ENDOCARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. 13/14 Gene Ontology BP GO:0003157 1.33097178649188e-05 1.54093349652817e-05 2865 1963 1944 1.20998167160791e-06 235 1.87695808317702 -1.81919392531373 -1 10.820715573042 2865 2211 1944 1150 3991 2739 1609 2649 235 1375 825 1813 M16086 GO_BASEMENT_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. 28/31 Gene Ontology BP GO:0071711 0.000441606298753614 0.000458864249240859 60 2069.54545454545 1944 4.01540879422527e-05 60 2.51126382074651 2.67248125237195 1 10.0358937603686 60 2557 627 1856 4498 1693 2332 3016 3414 768 1944 1814 M14753 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 810/1268 Gene Ontology BP GO:0051093 1.9553973313424e-10 4.66587886294164e-09 2595 2038.45454545455 1945 1.95539733151446e-11 112 2.2505675238308 2.484694284543 1 22.5727922205427 2595 1379 4516 385 1016 1945 3515 2663 1843 112 2454 1815 M15279 GO_RESPONSE_TO_HYDROPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROPEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. 20/26 Gene Ontology BP GO:0033194 2.46219823095455e-06 3.23999105447724e-06 1950 2095.81818181818 1948 2.23836453327671e-07 900 2.30377089447465 -2.03092785284229 -1 15.1916244844782 1247 2618 1948 2464 3502 1946 900 1618 1754 2651 2406 1816 M12439 GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 45/63 Gene Ontology BP GO:0010464 7.99103053440123e-07 1.25700693294689e-06 1325 1768.81818181818 1951 7.26457585179456e-08 159 2.21552188359363 2.70871775911895 1 15.707549905979 1325 2883 1951 1231 2913 736 1712 2283 1960 2304 159 1817 M11100 GO_HYALURONAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 18/19 Gene Ontology BP GO:0030214 1.95089369030027e-07 4.93024708629241e-07 2160 2000.54545454545 1952 1.77353987572697e-08 267 1.72868984837312 1.83591613564847 1 13.0831907668577 2157 987 2271 3860 1762 1056 267 1692 3769 1952 2233 1818 M12011 GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION.html Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. 14/24 Gene Ontology BP GO:0071675 3.20617404982246e-06 4.12906943089507e-06 1975 2082.45454545455 1953 2.91470792941422e-07 833 3.02378858783355 2.90995562170076 1 19.586665519422 1974 1127 833 1777 3589 2737 3738 993 1953 1207 2979 1819 M12321 GO_REGULATION_OF_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. 18/20 Gene Ontology BP GO:0090231 2.40807946836126e-06 3.17416254002406e-06 1625 1731.90909090909 1954 2.18916554927702e-07 287 1.85996517663159 2.18264369832979 1 12.2652806784515 1621 2173 2485 2035 3495 1526 726 1971 778 1954 287 1820 M15587 GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS.html The process in which any suture between cranial and/or facial bones is generated and organized. 16/20 Gene Ontology BP GO:0097094 4.99090322394266e-06 6.20595208471545e-06 1955 1898.63636363636 1954 4.5371950420942e-07 495 2.09754472363945 1.3141813751777 1 13.1064636245353 1954 1049 1706 1127 3718 1115 495 2581 2366 2419 2355 1821 M16002 GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rho protein signal transduction. 131/144 Gene Ontology BP GO:0035023 7.5344752329772e-08 4.02645553947883e-07 2630 1952.36363636364 1955 6.84952317365e-09 454 2.28841049142584 2.71207392028637 1 17.5960419939128 2630 1794 454 706 652 3313 4386 2241 1955 580 2765 1822 M14205 GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a myeloid leukocyte. 44/91 Gene Ontology BP GO:0002444 3.07290586097794e-07 6.35759491824382e-07 1920 2027.45454545455 1956 2.79355117290359e-08 1015 1.92697616733722 -1.78206966078079 -1 14.3383433740741 1917 1941 2056 2721 2191 2326 1261 1930 1015 2988 1956 1823 M13589 GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT.html The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 18/29 Gene Ontology BP GO:0034219 2.95345897470419e-07 6.17360494577655e-07 3855 1925 1957 2.68496306472784e-08 31 3.37726313884353 -2.92161329527715 -1 25.2592948779183 3853 1000 900 1252 2167 3408 2016 826 31 1957 3765 1824 M11743 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that modulates the frequency, rate or extent of extracellular matrix organization. 41/44 Gene Ontology BP GO:1903053 4.83762793662405e-08 4.02645553947883e-07 3090 1977.54545454545 1958 4.39784367545429e-09 223 2.02606183553927 -2.17113390311443 -1 15.5669878431478 3088 1958 1818 1211 223 2077 1538 2259 2822 1629 3130 1825 M11314 GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS.html Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 10/12 Gene Ontology BP GO:0050930 1.26714471115261e-07 4.16747130248656e-07 1555 1962.63636363636 1960 1.15194980376088e-08 1118 2.87210995213899 2.93330478301968 1 22.058555932065 1553 3075 1142 2882 1306 1280 1118 3039 2089 2145 1960 1826 M15580 GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. 42/53 Gene Ontology BP GO:0000096 4.89682149293539e-07 8.70982813709036e-07 830 2088.63636363636 1960 4.45165689353086e-08 828 1.60313728124158 1.76390756425378 1 11.6463332150441 828 1960 3091 2705 2570 1324 1450 1717 2171 3277 1882 1827 M16661 GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS.html Any process that alters the size or shape of an auditory receptor cell. 16/25 Gene Ontology BP GO:0002093 2.34197920784765e-07 5.38666794568221e-07 1960 1935.45454545455 1960 2.12907223378164e-08 90 1.96193887793849 -2.08969393087589 -1 14.771137841258 2228 2668 2511 1405 1960 1960 1186 1281 90 3592 2409 1828 M15962 GO_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_MEDIATED_ENDOCYTOSIS.html An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. 42/51 Gene Ontology BP GO:0072583 3.27682863815591e-07 6.64650551584109e-07 2930 2119.45454545455 1961 2.9789355692991e-08 68 1.69551114595667 -1.17132371904306 -1 12.5641028165622 2928 545 2927 970 2238 1949 1800 1961 68 3847 4081 1829 M16837 GO_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 132/200 Gene Ontology BP GO:0051592 1.03966610378233e-07 4.02645553947883e-07 4105 2580.45454545455 1962 9.45151048104009e-09 444 2.35770121846651 2.44334547946451 1 18.1319495892321 4103 1804 444 1722 1061 3608 4592 4626 1962 675 3788 1830 M10106 GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 22/37 Gene Ontology BP GO:0010831 3.84599475198057e-06 4.87347864405381e-06 1315 2105.90909090909 1963 3.4963649777145e-07 1120 2.05925745044221 -2.34706628475464 -1 13.12676910489 1311 2606 2482 2865 3646 1963 1217 1488 1120 2577 1890 1831 M14277 GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 43/56 Gene Ontology BP GO:0051353 2.63565617506478e-07 5.72483241320837e-07 1845 2059.54545454545 1963 2.3960513552938e-08 1218 2.07114677833355 -2.21693965114377 -1 15.5328439931834 1845 1963 1880 2776 2081 2353 1218 1672 2946 1325 2596 1832 M10764 GO_RESPONSE_TO_CORTICOSTEROID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTEROID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 196/288 Gene Ontology BP GO:0031960 6.39951489705759e-10 1.38497408446553e-08 3325 2135.54545454545 1965 5.81774081719921e-11 147 2.46645855622309 2.50015910918321 1 23.3385592689064 3324 1685 147 717 627 3131 4144 3770 1965 360 3621 1833 M13100 GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. 106/171 Gene Ontology BP GO:0050709 1.93978127178318e-07 4.91869332839625e-07 1965 2029.81818181818 1965 1.7634376752885e-08 1112 2.11258751544465 -2.25915837516142 -1 16.0140994290778 1965 1839 1247 1112 1754 2129 2284 3800 2458 1710 2030 1834 M13821 GO_DISTAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISTAL_TUBULE_DEVELOPMENT.html The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. 12/19 Gene Ontology BP GO:0072017 2.66631462454286e-07 5.75701307057915e-07 2665 1807.81818181818 1966 2.42392267971809e-08 126 2.61715673038141 2.82398416460453 1 19.6471561126695 2661 1188 1966 1006 2094 2213 2598 871 126 1602 3561 1835 M11976 GO_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE.html Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. 968/1913 Gene Ontology BP GO:0006952 2.39982718496214e-14 1.04358840108681e-12 1525 1932 1967 2.39982718496217e-15 67 2.33881543691833 -2.40053503900178 -1 33.787317251088 1524 1351 4336 1688 1190 2386 1967 2028 2533 67 2182 1836 M11026 GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 15/16 Gene Ontology BP GO:0009070 3.324053013631e-06 4.26906394491445e-06 490 1784.81818181818 1969 3.02187094187604e-07 443 2.06553271926329 1.68130206166349 1 13.3107385210726 486 2664 2027 2670 3599 852 443 866 2278 1779 1969 1837 M14248 GO_RESPONSE_TO_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TEMPERATURE_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. 185/246 Gene Ontology BP GO:0009266 6.37855308806009e-08 4.02645553947883e-07 2680 2029.90909090909 1969 5.79868479363288e-09 461 2.22257961545639 2.37122474563664 1 17.0868935415112 2680 3137 802 1969 461 1350 2814 4151 2819 1069 1077 1838 M15825 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION.html The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. 26/30 Gene Ontology BP GO:0040001 5.09543626404508e-07 8.95695690842529e-07 1200 1896.18181818182 1969 4.63221585836656e-08 577 1.81971844337795 2.41013074440837 1 13.20690151083 1197 841 2510 3394 2601 1532 2208 577 1969 3123 906 1839 M13781 GO_CELLULAR_RESPONSE_TO_CHOLESTEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CHOLESTEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. 25/28 Gene Ontology BP GO:0071397 1.08059393593295e-06 1.58362317603025e-06 955 1901.09090909091 1970 9.82358606089487e-08 157 2.44584809516214 2.67088662892637 1 17.054484707085 954 3269 1854 3228 3140 702 699 2383 2556 1970 157 1840 M16924 GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. 288/418 Gene Ontology BP GO:0043062 4.29051498463906e-25 1.05072453808029e-22 275 1664.90909090909 1970 3.90046816785369e-26 9 2.62697180384986 2.83924753448312 1 69.7239306909144 272 2345 9 1234 3068 1632 2554 1970 3062 62 2106 1841 M14530 GO_STRAND_DISPLACEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRAND_DISPLACEMENT.html The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. 25/27 Gene Ontology BP GO:0000732 1.79685909077334e-05 2.04770642894156e-05 250 1850.63636363636 1971 1.63352160623821e-06 154 1.48564640478529 1.63163857101343 1 8.32146014228337 247 2957 3246 2037 4056 286 154 1258 2772 1971 1373 1842 M16020 GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. 17/28 Gene Ontology BP GO:0036151 9.26190006063152e-07 1.40973572071045e-06 515 1630.90909090909 1972 8.41991269077425e-08 189 2.19390008828908 -2.15655869290579 -1 15.4211171997524 512 2658 2231 1972 3021 365 199 189 3344 2599 850 1843 M16040 GO_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_PHOSPHORYLATION.html The modification of histones by addition of phosphate groups. 37/59 Gene Ontology BP GO:0016572 4.62604632241999e-07 8.40141046894164e-07 2055 1948.90909090909 1972 4.2054975410558e-08 820 1.99068740458519 2.18485700039399 1 14.5243590310279 2052 1972 2219 1650 2512 1714 820 3435 908 1426 2730 1844 M10892 GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. 55/70 Gene Ontology BP GO:0032272 1.69220771967191e-07 4.56454638819326e-07 2510 1960.27272727273 1973 1.53837077257641e-08 266 2.26400000567955 2.20510114965802 1 17.2580907846121 2506 381 1509 1301 1639 1973 3398 3044 266 2060 3486 1845 M14629 GO_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of B cell proliferation. 56/96 Gene Ontology BP GO:0030888 5.87034972862894e-08 4.02645553947883e-07 1410 2184.27272727273 1973 5.33668171388172e-09 389 2.06768863592555 -1.95509693370593 -1 15.8889373946766 1410 3684 1973 3483 389 1329 922 2485 4115 1939 2298 1846 M14856 GO_MYELIN_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_ASSEMBLY.html The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. 25/30 Gene Ontology BP GO:0032288 3.26994418260974e-07 6.63832909322998e-07 4385 1990.81818181818 1974 2.9726769714856e-08 232 2.92150892480537 -2.25456147126935 -1 21.7253464834229 4382 880 1311 527 2236 3753 3038 232 252 1974 3314 1847 M16350 GO_RESPONSE_TO_WATER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. 21/31 Gene Ontology BP GO:0009415 1.25420935254904e-06 1.79508954703497e-06 1545 2349 1975 1.14019097051663e-07 380 2.73351578027703 3.08984697206753 1 18.892497510478 1542 3296 1975 3217 3211 1842 1810 380 4101 2843 1622 1848 M16600 GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 78/125 Gene Ontology BP GO:0043266 1.14552411839057e-07 4.07501813675178e-07 3615 2179.18181818182 1975 1.04138561639744e-08 209 2.49411488996886 2.85843287185222 1 19.1712935614883 3615 209 528 1304 1189 3386 4527 4543 1975 614 2081 1849 M16861 GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION.html A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. 22/22 Gene Ontology BP GO:0042772 6.97638127245105e-07 1.12829690861017e-06 1645 1913.63636363636 1975 6.34216680429092e-08 398 2.21709078116976 2.40279417786219 1 15.8445392390205 1645 2110 1798 2884 2833 803 565 1975 398 3276 2763 1850 M16931 GO_PROTEIN_HETEROOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 122/185 Gene Ontology BP GO:0051291 3.42615544712549e-07 6.84715782949634e-07 3310 1971.54545454545 1975 3.11468725517788e-08 23 2.18565734057973 -1.85765164299238 -1 16.1918114274224 3308 23 616 914 2271 2950 1975 3873 1817 812 3128 1851 M16954 GO_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of vasculature development. 269/372 Gene Ontology BP GO:1901342 1.80772812664396e-12 6.18482277446642e-11 1355 1756 1975 1.64338920604131e-13 86 2.39809400054949 2.49188679802903 1 29.5047301076735 1352 2352 86 929 1975 1562 3340 2245 2676 179 2620 1852 M10690 GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an alpha-amino acid. 69/84 Gene Ontology BP GO:1901607 4.24444617261182e-07 7.94105671136421e-07 960 1977.63636363636 1976 3.85858817408216e-08 284 1.64519116115654 1.56190426173941 1 12.034392237205 959 284 2762 3148 2439 1584 1874 1644 2241 1976 2843 1853 M16782 GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 333/547 Gene Ontology BP GO:0034762 2.33633338325012e-14 1.02556219172291e-12 3315 2014.45454545455 1976 2.12393943931831e-15 64 2.37696747674062 2.55083849259418 1 34.3619075360672 3314 1529 64 381 787 1976 3846 4376 2430 168 3288 1854 M10505 GO_COLLAGEN_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_FIBRIL_ORGANIZATION.html Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. 54/60 Gene Ontology BP GO:0030199 3.13041287129781e-05 3.49048911817606e-05 135 1998.90909090909 1977 2.84587037754331e-06 132 2.70006719948043 2.88055660737071 1 14.4515424193003 132 2868 458 1796 4425 1977 2427 2530 3076 599 1700 1855 M15165 GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. 15/17 Gene Ontology BP GO:0090266 6.13531531473841e-06 7.48888304288505e-06 1825 1828.54545454545 1977 5.57757493167995e-07 310 1.97211051379698 2.4587322173074 1 12.1218917986895 1824 2683 2478 2057 3784 1690 575 1977 500 2236 310 1856 M13943 GO_LIPID_PARTICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. 14/19 Gene Ontology BP GO:0034389 2.39194389468811e-07 5.45574261861949e-07 1830 2106.72727272727 1978 2.1744946861378e-08 160 1.39670654059184 -1.4421840088499 -1 10.4765806457717 1829 2699 3239 3679 1978 1661 1114 2396 700 3719 160 1857 M11127 GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of endothelial cell differentiation. 31/40 Gene Ontology BP GO:0045601 4.55695484135939e-07 8.3153068251175e-07 1840 1933.27272727273 1981 4.14268707751033e-08 545 2.28942720669196 -2.33650023580539 -1 16.7318484712614 1840 1999 1041 1981 2499 2907 2528 1221 3229 545 1476 1858 M13086 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. 220/306 Gene Ontology BP GO:1904950 7.45860939212331e-08 4.02645553947883e-07 1985 2128.54545454545 1983 6.78055422271894e-09 644 1.83797103650393 -1.81118029839809 -1 14.1122580096229 1983 1661 2325 2890 644 1671 1719 3880 2520 2858 1263 1859 M16776 GO_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ASSEMBLY.html Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 37/40 Gene Ontology BP GO:0030032 6.21291457146507e-08 4.02645553947883e-07 4355 2159.63636363636 1983 5.64810431538277e-09 438 1.94457639399086 1.93735841613786 1 14.9367640181315 4352 582 1593 1496 438 3541 3550 2596 745 1983 2880 1860 M12129 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition. 26/30 Gene Ontology BP GO:1902751 7.17238198294899e-08 4.02645553947883e-07 1090 1890.90909090909 1984 6.520347469801e-09 517 1.43207728135821 1.7294211852337 1 10.9729988971077 1089 842 3115 2488 598 1984 2031 3630 517 3117 1389 1861 M14610 GO_REGULATION_OF_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROVILLUS_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. 24/32 Gene Ontology BP GO:0032530 1.07786951817101e-06 1.58089875652441e-06 3320 2144.81818181818 1984 9.79881860239548e-08 289 2.77063970301033 -3.22386678963992 -1 19.3353793851721 3316 835 1170 1063 3136 4420 4201 668 289 2511 1984 1862 M15705 GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. 26/55 Gene Ontology BP GO:0042462 2.5383211942877e-06 3.3288637308401e-06 1985 2001.81818181818 1984 2.3075673845115e-07 467 2.81444211513746 2.97385623616315 1 18.541934962531 1984 2942 1164 2405 3517 2273 2753 467 1828 1443 1244 1863 M15965 GO_RESPONSE_TO_GONADOTROPIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GONADOTROPIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 24/37 Gene Ontology BP GO:0034698 2.86086913481631e-07 6.03154693443602e-07 3720 2226.72727272727 1986 2.60079046076581e-08 839 2.13809700217257 1.74042914827991 1 15.9796645659438 3717 839 1514 923 2147 4041 3700 1986 1245 1463 2919 1864 M10479 GO_VENTRICULAR_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_MORPHOGENESIS.html The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. 38/43 Gene Ontology BP GO:0060412 2.42672698976738e-07 5.50807838214029e-07 1180 2603.90909090909 1987 2.20611568859037e-08 755 2.22858393342141 2.25983290497491 1 16.7665708756014 4491 1961 1177 1177 1987 4161 3170 4286 1051 755 4427 1865 M10979 GO_NOTCH_RECEPTOR_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_RECEPTOR_PROCESSING.html The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. 18/20 Gene Ontology BP GO:0007220 2.11833068534436e-06 2.83724602156227e-06 2160 1903.54545454545 1987 1.92575702276386e-07 81 2.02566498643472 -1.14549015070143 -1 13.4865229125374 1841 2160 2156 1839 3444 1405 780 1987 81 3144 2102 1866 M12261 GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. 34/46 Gene Ontology BP GO:0030513 1.03329545344332e-07 4.02645553947883e-07 2975 2239.63636363636 1987 9.39359547250114e-09 634 1.92731791153593 1.90218075077568 1 14.8032836488773 2972 634 1344 795 1052 1987 4094 4148 2742 772 4096 1867 M12573 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 266/314 Gene Ontology BP GO:0010948 4.28940925144528e-07 7.99944739357711e-07 1260 2325.90909090909 1987 3.89946371615011e-08 1018 1.66859766172475 1.83801153624363 1 12.2006523747256 1257 3634 3548 3941 2445 1018 1214 1697 1987 3435 1409 1868 M15732 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY.html Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. 16/17 Gene Ontology BP GO:0010715 8.39277441812945e-08 4.02645553947883e-07 3560 2027.90909090909 1987 7.62979521664108e-09 489 2.31145852326318 -2.66891333073464 -1 17.774299833689 3556 1072 1678 1987 789 2909 1659 2171 489 2421 3576 1869 M10718 GO_DENDRITIC_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_CHEMOTAXIS.html The movement of a dendritic cell in response to an external stimulus. 9/38 Gene Ontology BP GO:0002407 6.33621043797728e-07 1.05633777025827e-06 1990 1822.90909090909 1988 6.33621224461831e-08 62 3.50557358500392 -3.48497113285757 -1 25.2339153224343 1988 1243 4257 173 2832 2298 2063 608 62 1901 2627 1870 M11978 GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 211/267 Gene Ontology BP GO:0008654 2.42809044852895e-07 5.50848603461979e-07 305 1751.54545454545 1988 2.20735519682897e-08 148 1.53240159929949 -1.5428978952217 -1 11.4966771011084 301 3133 3609 2907 1988 148 648 498 2152 3616 267 1871 M14101 GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 16/18 Gene Ontology BP GO:0046475 1.48708204864662e-06 2.07743032948326e-06 1385 1946.72727272727 1988 1.35189368530483e-07 270 2.77098145497174 -2.80057254739209 -1 18.9402475500455 1384 3330 1988 2706 3298 1236 590 614 3582 2416 270 1872 M14273 GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 234/288 Gene Ontology BP GO:0010810 1.24523329834939e-07 4.14338946095474e-07 2590 2189.18181818182 1988 1.13203033530135e-08 309 2.20929207117437 2.3450690499405 1 16.9509056813037 2586 1621 309 1734 1285 1988 3888 3925 2975 336 3434 1873 M16445 GO_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cell proliferation. 1488/2183 Gene Ontology BP GO:0042127 7.14951054116621e-17 4.62037118722866e-15 2565 1946.27272727273 1989 7.14951054116621e-18 44 2.12876726705844 2.32295031041495 1 36.8036967933139 2564 1309 4624 337 380 1833 3936 2213 2180 44 1989 1874 M15320 GO_RESPONSE_TO_MINERALOCORTICOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MINERALOCORTICOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. 38/50 Gene Ontology BP GO:0051385 1.87262113224346e-07 4.82197350765291e-07 2055 2278.27272727273 1992 1.70238299239944e-08 803 2.65076263259653 2.92198840116571 1 20.1475197749096 2051 4193 1625 803 1725 2925 3725 1992 1829 2942 1251 1875 M13918 GO_RETINOIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. 16/33 Gene Ontology BP GO:0042573 8.50486474643114e-07 1.31688843264187e-06 820 1920.27272727273 1994 7.73169821298549e-08 284 2.83352450086892 2.76262586484021 1 20.0485069314542 816 2661 1199 3158 2964 671 284 3017 3106 1994 1253 1876 M16225 GO_EPITHELIAL_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MATURATION.html The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 16/25 Gene Ontology BP GO:0002070 1.45122457950315e-07 4.32578345190784e-07 3280 1990.45454545455 1996 1.31929515930257e-08 659 1.85067494649269 -2.11728348819937 -1 14.1408106844258 3276 2206 2317 1566 1463 3629 3116 801 659 1996 866 1877 M15920 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT.html Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. 21/25 Gene Ontology BP GO:0061311 3.10766528502945e-07 6.41240202715832e-07 2945 1827.09090909091 1998 2.82515065819146e-08 217 2.4092932210892 -2.24005630462444 -1 17.9421006811029 2945 877 906 217 2196 3049 1998 3994 315 1076 2525 1878 M16471 GO_BILE_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 31/68 Gene Ontology BP GO:0008206 2.31328631903919e-07 5.33650036811569e-07 2130 1839.81818181818 1998 2.10298778389077e-08 923 2.80242749142309 -2.43701689186445 -1 21.1569276686649 2060 1998 923 1069 1954 2130 2002 2662 1482 2126 1832 1879 M14075 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/23 Gene Ontology BP GO:0051590 1.29890949289034e-07 4.18739690741189e-07 3030 2061.09090909091 2000 1.18082688143609e-08 1119 1.95308351579451 -1.70931838293135 -1 14.9623546669494 3027 1119 1933 2228 1335 2754 2000 1439 3373 1209 2255 1880 M13562 GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 9/12 Gene Ontology BP GO:0060394 1.12969276093032e-06 1.64315736686739e-06 790 2100.54545454545 2001 1.12969333522331e-07 383 1.64112292406969 1.48936123147602 1 11.3775869559167 789 2282 4436 2001 3205 383 496 3666 3507 1903 438 1881 M15745 GO_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON_REORGANIZATION.html A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. 82/107 Gene Ontology BP GO:0031532 7.42031289480655e-08 4.02645553947883e-07 4175 2513.63636363636 2001 6.74573922280367e-09 203 1.96396883185757 -1.6245700820574 -1 15.0867488023643 4175 203 2001 1795 638 3884 3470 3288 1834 1790 4572 1882 M10141 GO_DENTATE_GYRUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENTATE_GYRUS_DEVELOPMENT.html The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. 9/19 Gene Ontology BP GO:0021542 3.09828667847897e-07 6.39656754858952e-07 2240 1940.63636363636 2002 3.09828711045116e-08 230 2.30534554322291 1.98386508102218 1 17.1665499120266 2236 2288 4227 2002 2264 1420 459 230 1864 2446 1911 1883 M14077 GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. 30/40 Gene Ontology BP GO:0046460 2.84502725558825e-07 6.01176740247598e-07 540 1541.54545454545 2002 2.58638874864144e-08 152 2.00786951052933 -2.03481567595875 -1 15.0035661911463 538 2928 2024 3369 2142 507 596 152 2293 2002 406 1884 M14468 GO_RESPONSE_TO_VITAMIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. 33/35 Gene Ontology BP GO:0033197 2.74603732568534e-05 3.0714691529841e-05 865 2295.81818181818 2002 2.49642872935348e-06 599 2.49340612318795 2.76611612196633 1 13.5050344192856 861 2002 599 1455 4136 2425 3914 3527 3726 695 1914 1885 M15906 GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 30/38 Gene Ontology BP GO:0046473 2.55478083903835e-07 5.65745344301423e-07 560 1882.72727272727 2004 2.32252830519628e-08 557 1.80603233508019 -2.03339589479284 -1 13.5426343196125 557 3241 2428 2877 2039 1192 1107 610 3450 2004 1205 1886 M11704 GO_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DIFFERENTIATION.html The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 94/108 Gene Ontology BP GO:0045446 2.48445153849931e-07 5.59143257290898e-07 3795 2181.09090909091 2005 2.25859256278864e-08 123 2.24918480756539 2.31521915585218 1 16.9047680819323 3793 123 720 689 2005 3879 3140 3505 891 907 4340 1887 M16472 GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 30/40 Gene Ontology BP GO:0046463 2.84502725558825e-07 6.01176740247598e-07 540 1547.27272727273 2005 2.58638874864144e-08 203 2.00786951052933 -2.03481567595875 -1 15.0035661911463 539 2929 2025 3370 2143 508 597 203 2294 2005 407 1888 M10905 GO_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSPORT.html The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 413/695 Gene Ontology BP GO:0030001 2.13040810610631e-17 1.47952073398696e-15 2870 1816 2006 1.93673464191483e-18 35 2.33304532000193 -2.13802169687255 -1 41.7407143677417 2868 1476 35 2156 588 2006 2348 3421 1722 91 3265 1889 M15573 GO_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. 33/132 Gene Ontology BP GO:0009620 1.61222349992024e-07 4.4655132638076e-07 3745 2480.45454545455 2007 1.46565783460786e-08 787 2.83567942565834 -3.87987242571505 -1 21.6745743532527 3743 2007 787 1780 1590 4346 3155 4034 1867 1767 2209 1890 M11524 GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 11/20 Gene Ontology BP GO:0019370 2.44675444360556e-07 5.53132660470759e-07 2010 2085.27272727273 2008 2.22432246884011e-08 452 1.78859323763626 1.90181669074659 1 13.4320527010812 2008 2248 2152 2693 1995 1418 452 1313 4202 1858 2599 1891 M11501 GO_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of the process of creating protein polymers. 184/225 Gene Ontology BP GO:0032271 6.09607130918098e-08 4.02645553947883e-07 4320 2550.72727272727 2009 5.54188316190867e-09 419 1.89094365762495 2.01540336237734 1 14.521958285766 4316 1699 2009 1328 419 4576 3865 3058 712 1940 4136 1892 M14088 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. 82/150 Gene Ontology BP GO:0045621 6.30816607529187e-07 1.05263043393331e-06 995 1901.09090909091 2009 5.73469807642134e-08 199 1.63497924191982 -1.49816214095237 -1 11.7170324353025 993 199 2597 2481 2745 1330 2170 2009 3537 1280 1571 1893 M10983 GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. 15/17 Gene Ontology BP GO:1903504 6.13531531473841e-06 7.48888304288505e-06 1825 1829.90909090909 2010 5.57757493167995e-07 309 1.97211051379698 2.4587322173074 1 12.1218917986895 1823 2682 2477 2056 3783 1689 574 2010 499 2227 309 1894 M13508 GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. 236/273 Gene Ontology BP GO:0045930 8.63003623053717e-08 4.02645553947883e-07 945 1944.27272727273 2010 7.84548779006493e-09 268 1.78239802804694 1.99058239257038 1 13.6824458457332 945 3636 3248 3489 836 268 1116 2054 2010 2846 939 1895 M16532 GO_CELLULAR_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_DEFENSE_RESPONSE.html A defense response that is mediated by cells. 52/121 Gene Ontology BP GO:0006968 1.34051792907078e-06 1.89991773498823e-06 50 1907.81818181818 2010 1.21865340534941e-07 48 1.55330448551757 -1.60708267500329 -1 10.6447954122973 48 2476 2363 3433 3252 798 731 364 4222 2010 1289 1896 M11784 GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 178/213 Gene Ontology BP GO:0032869 4.15424907872913e-08 4.02645553947883e-07 1515 2057.90909090909 2011 3.77659014288509e-09 148 1.55613675655038 -1.59442928423975 -1 11.9324983549179 1513 2376 3438 2231 148 1372 1485 2011 2666 3832 1565 1897 M16100 GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. 97/119 Gene Ontology BP GO:0032273 5.32607503019624e-08 4.02645553947883e-07 3695 2171.54545454545 2011 4.84188650830683e-09 116 1.8932822422066 -1.77342431951493 -1 14.5400453414679 3692 116 2011 1366 295 3582 2556 4076 754 1984 3455 1898 M15441 GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 67/82 Gene Ontology BP GO:0051785 3.32123622677466e-07 6.70152305428557e-07 1330 1940.18181818182 2012 3.01930611651467e-08 333 2.15287787382954 2.1748910100782 1 15.9717402412587 1329 2461 1768 2577 2251 839 333 2640 3409 2012 1723 1899 M14293 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. 30/60 Gene Ontology BP GO:0032753 1.66374180973817e-05 1.90252903433564e-05 315 2134.27272727273 2013 1.51250399259717e-06 311 1.41710384763348 -1.24290582441224 -1 7.98752073631532 311 2013 2641 2575 4041 910 1479 1534 3623 2611 1739 1900 M16820 GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. 20/23 Gene Ontology BP GO:1900025 1.05442630324176e-07 4.02645553947883e-07 1695 2003.72727272727 2013 9.58569412526181e-09 596 2.06401046703456 1.95210251683961 1 15.8604897404271 1694 2989 2013 2918 1082 596 1490 2741 1978 2282 2258 1901 M16401 GO_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. 15/19 Gene Ontology BP GO:0070231 5.75421547773225e-08 4.02645553947883e-07 2015 2248.27272727273 2014 5.23110511657889e-09 368 1.16179037919005 1.28361047842452 1 8.88254884738896 2014 2224 3514 3308 368 1629 1155 1386 3766 3480 1887 1902 M11462 GO_DETECTION_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_OTHER_ORGANISM.html The series of events in which a stimulus from another organism is received and converted into a molecular signal. 31/63 Gene Ontology BP GO:0098543 3.64922791078796e-06 4.64565183827534e-06 30 1816.54545454545 2015 3.31748542174743e-07 30 1.37920330857358 -1.35383706720316 -1 8.79243405423736 30 2015 2783 2565 3628 283 301 684 4196 2122 1375 1903 M14545 GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. 17/21 Gene Ontology BP GO:2000773 2.10056117353793e-06 2.81587759737021e-06 1965 2285.72727272727 2015 1.90960289014322e-07 688 2.67640917387807 3.13653597002118 1 17.8627662406958 1962 4523 2617 2146 3441 1316 985 2015 688 3699 1751 1904 M16045 GO_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 1290/1589 Gene Ontology BP GO:0033043 9.78351624700051e-08 4.02645553947883e-07 2045 2093.81818181818 2015 9.78351667772788e-09 977 1.71737780537285 1.87701393981365 1 13.1795671393236 2044 1324 4589 1563 1110 1785 2522 977 2031 3072 2015 1905 M10070 GO_APICAL_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, apical regions of the cell. 23/30 Gene Ontology BP GO:0045176 2.61299995754356e-07 5.70140887477118e-07 2795 1913.36363636364 2016 2.37545478899703e-08 16 2.64818579192158 3.76787871690737 1 19.894813358358 2792 916 1677 1090 2070 3216 2899 3677 16 2016 678 1906 M12388 GO_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MEMBRANE.html The process of directing proteins towards a membrane, usually using signals contained within the protein. 190/285 Gene Ontology BP GO:0006612 2.44766848895185e-07 5.53132660470759e-07 280 2493.54545454545 2016 2.22515341933977e-08 277 1.18950990699424 -0.85381756048263 -1 8.89854614396739 277 4357 4170 3358 1996 585 371 2016 3938 4573 1788 1907 M13565 GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. 30/52 Gene Ontology BP GO:0002726 1.60351056693697e-05 1.84043775726633e-05 90 2078.90909090909 2016 1.45774750412607e-06 86 1.23791367366806 -1.23375974062674 -1 6.98606848649715 86 2016 3173 2570 4028 449 880 1666 4200 2310 1490 1908 M11906 GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 38/53 Gene Ontology BP GO:0045744 4.58015662618763e-08 4.02645553947883e-07 2955 2051 2018 4.16377883776493e-09 188 2.05294806949752 2.20399705668614 1 15.7749310644579 2954 2528 2087 2018 188 1448 1853 2269 3997 1509 1710 1909 M10300 GO_REGULATION_OF_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATURATION.html Any process that modulates the frequency, rate or extent of cell maturation. 22/24 Gene Ontology BP GO:1903429 3.30903219948143e-07 6.68269393410899e-07 1645 1859.90909090909 2019 3.00821154290446e-08 322 2.10705045894028 2.45494697069343 1 15.6326786722336 1643 2971 2019 818 2248 1304 1743 2982 2193 2216 322 1910 M15099 GO_NEGATIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STAT_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of STAT cascade. 35/50 Gene Ontology BP GO:1904893 2.58845847383449e-07 5.67775356325191e-07 855 2275.36363636364 2019 2.35314434398666e-08 851 2.62195834573269 3.14247815635283 1 19.7024825302075 851 3718 1872 3892 2061 1288 978 2019 3396 3643 1311 1911 M16055 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 50/54 Gene Ontology BP GO:0060999 2.50797972933849e-07 5.61029310665405e-07 580 1485.27272727273 2019 2.27998183204174e-08 153 1.80933822477063 2.03898336903092 1 13.5755672755181 578 2482 2297 2087 2019 953 632 153 2027 2058 1052 1912 M12557 GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. 35/42 Gene Ontology BP GO:2000279 1.72080859156988e-06 2.36475531755745e-06 780 2157.45454545455 2020 1.56437267051206e-07 312 2.28368177173321 2.520622603049 1 15.4359620288363 779 4212 2698 3080 3354 842 312 2020 1065 3970 1400 1913 M13553 GO_POSITIVE_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINESIS.html Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. 31/66 Gene Ontology BP GO:0032467 2.19219762742537e-07 5.15766410370363e-07 2220 2113.54545454545 2020 1.992907132607e-08 1008 1.90949725426302 1.98387839246737 1 14.4171315461522 2020 2912 2402 3390 1909 2218 1008 2220 1932 1801 1437 1914 M10305 GO_URETER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_URETER_DEVELOPMENT.html The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. 14/21 Gene Ontology BP GO:0072189 5.47602583739338e-07 9.45803571692332e-07 2420 2231.81818181818 2021 4.97820654584809e-08 1115 2.36077873221998 2.48684518194399 1 17.0968505248567 2419 1115 1397 2091 2649 1759 1904 4031 3603 1561 2021 1915 M11642 GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/27 Gene Ontology BP GO:0034035 3.94090714378728e-06 4.97883272876519e-06 845 1838 2021 3.58264927566945e-07 227 2.27337680969613 -2.28473465172909 -1 14.4768439162665 842 3582 2437 2878 3656 594 227 600 2021 2778 603 1916 M13827 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. 11/17 Gene Ontology BP GO:0001956 3.60411192452546e-07 7.04915207432408e-07 4530 2661 2022 3.27646592269364e-08 1199 2.14627747885893 -1.91288245941284 -1 15.865447316768 4529 1199 2022 1352 2322 4297 4523 1956 1998 1864 3209 1917 M16827 GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 14/22 Gene Ontology BP GO:0071371 2.52296180900787e-07 5.63037951909527e-07 1530 1860.81818181818 2024 2.29360190758308e-08 591 2.10514804755071 -2.45078249948341 -1 15.8079261479814 1529 1167 2062 2949 2024 2217 1363 591 3218 2498 851 1918 M11579 GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of activated T cell proliferation. 28/43 Gene Ontology BP GO:0046006 1.04507603036317e-07 4.02645553947883e-07 4145 2420.09090909091 2025 9.50069163643538e-09 789 2.46886380938926 2.4794755602507 1 18.9917021035317 4144 789 1215 1727 1068 4340 4189 3129 2025 1166 2829 1919 M16792 GO_LUNG_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_ALVEOLUS_DEVELOPMENT.html The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. 48/56 Gene Ontology BP GO:0048286 2.78394383624506e-08 3.67156969866319e-07 3680 2337.45454545455 2025 2.53085806497627e-09 48 2.38185992323479 2.57313204297214 1 18.4342270869314 3678 2877 1643 1567 48 3612 4098 2572 1982 1610 2025 1920 M16698 GO_ASTROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DEVELOPMENT.html The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 22/39 Gene Ontology BP GO:0014002 9.50240373038997e-07 1.43534740556727e-06 1850 2324.09090909091 2027 8.63855257703764e-08 928 2.39721672992783 2.23200662358325 1 16.8371195874715 3251 928 1407 1551 3044 3837 3735 2090 1847 1848 2027 1921 M14837 GO_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATPASE_ACTIVITY.html Any process that modulates the rate of ATP hydrolysis by an ATPase. 89/124 Gene Ontology BP GO:0043462 3.15563613237172e-07 6.45698105713528e-07 2105 1872.63636363636 2029 2.86876053182724e-08 747 2.3041575007787 2.25746683462602 1 17.1462736747187 2102 3181 2029 1792 2215 1075 2433 1832 1062 2131 747 1922 M16513 GO_POLYOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 31/43 Gene Ontology BP GO:0046173 8.16870262576135e-07 1.2780421424905e-06 1800 2117.90909090909 2029 7.42609605349119e-08 1087 2.24831620980118 -2.34849827083929 -1 15.9219802907089 1799 2029 1817 3407 2931 2357 2305 1425 2013 2127 1087 1923 M12736 GO_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION.html The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 121/184 Gene Ontology BP GO:0042113 2.54115237521486e-07 5.6574076563994e-07 3015 2480.36363636364 2030 2.31013878975964e-08 1149 2.14513645844656 -2.10252044126777 -1 16.1047661994667 3012 1819 1294 1149 2030 3900 3075 4390 1753 1283 3579 1924 M10400 GO_PIGMENT_GRANULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_LOCALIZATION.html Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. 25/29 Gene Ontology BP GO:0051875 9.98685539566726e-07 1.48938583833461e-06 2035 1766.27272727273 2031 9.07896357198446e-08 197 2.11008788573309 -2.06688409921409 -1 14.7671471585965 2031 860 2074 716 3080 2573 2032 1730 197 2629 1507 1925 M14366 GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS.html A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. 32/34 Gene Ontology BP GO:0034067 7.48539865689051e-07 1.18953415131529e-06 845 2266.45454545455 2031 6.80491018524013e-08 138 0.95906353697869 -0.91687987949443 -1 6.7689467089617 844 2031 3847 3518 2884 639 138 1573 3931 4111 1415 1926 M16008 GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of ARF protein signal transduction. 14/16 Gene Ontology BP GO:0032012 2.63686041332904e-05 2.95607234587613e-05 1690 2284.63636363636 2031 2.39717456232191e-06 38 2.17730782358093 -1.56861507307385 -1 11.8236925213559 1690 4065 2909 2031 4127 1460 1042 2176 38 3723 1870 1927 M13403 GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 29/38 Gene Ontology BP GO:0045662 5.05983989412634e-07 8.91796781339768e-07 3365 1881.63636363636 2032 4.59985550713915e-08 202 2.45165813762867 2.799617691563 1 17.8346782509765 3363 715 948 202 2593 3289 4294 2032 583 538 2141 1928 M13410 GO_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 40/73 Gene Ontology BP GO:0042116 1.17887312249144e-07 4.08807542125352e-07 3170 2257.09090909091 2032 1.07170289605593e-08 1222 2.31258136153113 2.14815820617008 1 17.7645362117737 3170 2888 1491 1812 1222 3975 3013 1367 1818 2032 2040 1929 M14727 GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. 104/151 Gene Ontology BP GO:1904064 2.50088400428821e-07 5.59991014049714e-07 2850 2198.90909090909 2032 2.27353117143647e-08 579 2.46265581034657 2.71140141181603 1 18.5170183049116 2847 1828 579 2647 2017 2032 3727 4018 2451 934 1108 1930 M13590 GO_SULFUR_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSPORT.html The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 22/34 Gene Ontology BP GO:0072348 2.13386227333661e-07 5.11269884543525e-07 1095 2093.81818181818 2033 1.93987498209811e-08 602 1.95882413586808 -1.91642993929753 -1 14.8012291083258 1095 2138 2300 4300 1870 1633 2033 602 2730 1845 2486 1931 M16494 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 17/42 Gene Ontology BP GO:0003071 2.54680249366442e-07 5.65745344301423e-07 3595 2143.18181818182 2033 2.31527526226534e-08 805 2.0604169978781 -1.78688414213023 -1 15.4646538108577 3591 2183 1832 1994 2033 2513 805 1638 2283 1754 2949 1932 M16527 GO_RESPONSE_TO_REDOX_STATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REDOX_STATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. 36/54 Gene Ontology BP GO:0051775 9.93522612383563e-08 4.02645553947883e-07 3195 2271.18181818182 2034 9.03202415682875e-09 344 2.26554617793622 2.19814991174941 1 17.4192050666044 3193 3500 1979 1387 992 2034 2646 1391 344 3246 4271 1933 M11612 GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 50/61 Gene Ontology BP GO:0010591 3.86227260697772e-07 7.4046783849474e-07 2150 1631.54545454545 2035 3.51115753184559e-08 126 1.81102722716444 2.52347211864932 1 13.3243655329231 2146 459 2397 662 2379 2035 3800 621 511 2811 126 1934 M13001 GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. 37/48 Gene Ontology BP GO:2000171 6.8981073105683e-07 1.11719085680732e-06 3400 2376.36363636364 2035 6.27100861224827e-08 607 1.94362720140498 2.31979647463375 1 13.8876185804066 3398 607 2035 1547 2828 1972 1774 4651 1697 2533 3098 1935 M16545 GO_RESPONSE_TO_HISTAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HISTAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. 2/19 Gene Ontology BP GO:0034776 4.05452900837011e-05 4.47267033569136e-05 1355 2385.5 2036 4.50511341485647e-06 137 1.98395438453804 -1.98395438453804 -1 10.3330248564918 1353 2318 4633 NA 4213 1568 137 4014 543 3322 1754 1936 M11551 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. 42/70 Gene Ontology BP GO:0003333 2.55216898589207e-07 5.65745344301423e-07 1695 1901.27272727273 2037 2.32015389269393e-08 542 2.37250703670956 2.19504094550299 1 17.8226699391102 1691 542 971 3127 2037 2340 2202 2975 1100 1057 2872 1937 M13721 GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. 184/242 Gene Ontology BP GO:0045017 2.55456208752837e-07 5.65745344301423e-07 395 1696.72727272727 2038 2.32232944014102e-08 155 1.61412609098579 -1.61220375221221 -1 12.0926744926943 392 2797 3228 2427 2038 155 741 813 2274 3526 273 1938 M13069 GO_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JNK_CASCADE.html An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 86/112 Gene Ontology BP GO:0007254 2.55592849482275e-07 5.65745344301423e-07 1495 2378 2040 2.32357162887901e-08 1178 1.61345702168704 -1.52822954337591 -1 12.0876192970742 1494 2841 3141 3505 2040 1571 1178 1359 4152 3369 1508 1939 M13921 GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. 64/112 Gene Ontology BP GO:0031644 7.71536202580599e-08 4.02645553947883e-07 3135 2019.81818181818 2041 7.01396572398404e-09 329 3.11768860405539 3.08689134513933 1 24.0098358472996 3135 1889 329 2223 686 3259 3570 757 2041 897 3432 1940 M10352 GO_CELLULAR_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 24/40 Gene Ontology BP GO:0098586 7.99941768281047e-07 1.25747602966612e-06 2010 2254.63636363636 2042 7.27220053770853e-08 605 2.11974387144906 -2.38700578918238 -1 15.0236391003544 2010 890 2042 2237 2915 3185 4025 3796 605 1795 1301 1941 M14494 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. 31/67 Gene Ontology BP GO:0002833 6.98645527406948e-07 1.12953357853528e-06 205 1837.63636363636 2042 6.35132499339288e-08 185 1.38104938759294 -1.41217055334352 -1 9.83011281687255 204 2042 3033 3004 2834 404 185 1336 4089 2123 960 1942 M13468 GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION.html The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). 14/22 Gene Ontology BP GO:0042074 4.6779219452113e-08 4.02645553947883e-07 3040 1876 2043 4.25265640425388e-09 198 2.45257874352706 2.85042678356928 1 18.8657503224123 3040 1091 1781 240 198 2539 2500 2619 292 2043 4293 1943 M15372 GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle phase transition. 376/442 Gene Ontology BP GO:1901987 2.03440430458087e-07 4.99381053281994e-07 1010 2224.36363636364 2043 1.84945862973473e-08 859 1.5921064152851 1.74169506135561 1 12.0306436317447 1006 3120 3888 2618 1822 859 1111 2043 2282 3893 1826 1944 M12145 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. 26/48 Gene Ontology BP GO:0001916 4.47902284769835e-06 5.61144138673679e-06 120 1995.18181818182 2045 4.0718472424129e-07 119 1.14923877114296 -1.16239527743896 -1 7.19523179120276 119 2045 3223 2566 3689 401 449 1403 4283 2441 1328 1945 M16204 GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. 60/68 Gene Ontology BP GO:0008156 1.65812099744328e-06 2.28667368141778e-06 445 2504.90909090909 2045 1.50738386105097e-07 441 1.45899354013993 1.58549504414819 1 9.85024281355016 441 4417 3720 4568 3343 1001 485 2045 1345 4265 1924 1946 M13413 GO_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G1_S_PHASE_TRANSITION.html The cell cycle process by which a cell in G1 phase commits to S phase. 121/140 Gene Ontology BP GO:0044843 2.35270652247116e-06 3.11086770362555e-06 200 1935.72727272727 2047 2.13882639862513e-07 198 1.5388661948924 1.65401180289214 1 10.1463441395993 198 2824 3339 2047 3483 623 528 1375 2721 2194 1961 1947 M14407 GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. 121/140 Gene Ontology BP GO:0000082 2.35270652247116e-06 3.11086770362555e-06 200 1935.27272727273 2048 2.13882639862513e-07 199 1.5388661948924 1.65401180289214 1 10.1463441395993 199 2825 3340 2048 3484 624 529 1360 2722 2195 1962 1948 M15358 GO_RESPONSE_TO_X_RAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_X_RAY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). 35/37 Gene Ontology BP GO:0010165 1.86328311201364e-05 2.11821556809173e-05 2050 2465 2048 1.69390808474431e-06 952 1.7367684199297 2.08071576838005 1 9.71457598699009 2048 3964 3000 3807 4069 1566 952 1345 1285 3174 1905 1949 M15453 GO_REGULATION_OF_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_SPECIFICATION.html Any process that mediates the adoption of a specific fate by a cell. 14/24 Gene Ontology BP GO:0042659 0.000102657986963814 0.000109859156702536 715 1680.27272727273 2048 9.33297977980156e-06 237 1.94785630089706 2.1472787635621 1 9.22377183632874 715 2690 2165 2124 4317 542 237 1018 2270 2048 357 1950 M14093 GO_VENTRICULAR_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_DEVELOPMENT.html The progression of the ventricular septum over time from its formation to the mature structure. 67/78 Gene Ontology BP GO:0003281 1.52309637776569e-07 4.38675008470983e-07 2565 2225.81818181818 2050 1.38463316655653e-08 606 1.99879268846611 2.15885706948497 1 15.2661099426015 2565 1870 1333 2050 1519 2613 4085 3997 1598 606 2248 1951 M10124 GO_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ACTIVATION.html A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. 409/670 Gene Ontology BP GO:0045321 1.26913965949354e-07 4.16747130248656e-07 2450 1813.54545454545 2051 1.15376339337081e-08 263 2.01684554924264 -1.8344305808126 -1 15.4592424919214 2447 1494 343 713 1309 2796 2544 3241 2051 263 2748 1952 M12366 GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. 3/14 Gene Ontology BP GO:0021520 1.68936092975232e-07 4.56215693913961e-07 2760 1807.63636363636 2052 1.68936105817965e-08 18 1.41893212987033 1.41893212987033 1 10.778240557344 845 2759 4364 2331 3829 503 18 31 2052 2756 396 1953 M14454 GO_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_POTENTIATION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. 43/63 Gene Ontology BP GO:0060291 3.12978470452898e-07 6.43237112640165e-07 2275 2018.90909090909 2052 2.84525922707404e-08 1147 2.41684592477291 2.91169495388449 1 17.9947217369518 2273 1949 1219 2245 2203 1853 2078 3532 1657 1147 2052 1954 M12103 GO_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_EFFLUX.html The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 18/31 Gene Ontology BP GO:0033344 2.57920940477942e-07 5.67674433889539e-07 2545 2028.18181818182 2054 2.34473609741609e-08 237 3.03944530597596 3.7340850994646 1 22.8563301796404 2541 2175 1685 1555 2054 2611 3542 2633 237 1524 1753 1955 M14479 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition. 28/33 Gene Ontology BP GO:1902750 7.35149386764446e-07 1.17266030051936e-06 1545 2322.18181818182 2054 6.68317847655643e-08 1052 1.83578255200298 2.28848829557325 1 13.0646099199751 1543 4217 3328 3495 2874 2054 1168 1052 1336 3295 1182 1956 M15149 GO_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 27/35 Gene Ontology BP GO:0046058 7.43383839524939e-07 1.18295656816332e-06 1190 1919.81818181818 2054 6.75803718832504e-08 859 2.54667340812931 2.67147039549945 1 18.1519429762121 1187 2054 969 3138 2880 1353 1714 2798 2080 859 2086 1957 M11149 GO_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that modulates the frequency or rate of macrophage activation. 20/34 Gene Ontology BP GO:0043030 3.76464542533219e-07 7.25037051492992e-07 2430 2281.27272727273 2055 3.42240551776309e-08 973 2.13201747302233 -2.65075706528566 -1 15.7278349059616 2430 973 1594 2055 2365 3274 3666 1157 3682 1917 1981 1958 M13873 GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is regionalized in the dorsoventral axis. 17/25 Gene Ontology BP GO:0021904 6.54870273957093e-07 1.08207080423379e-06 2510 1881.09090909091 2056 5.95336789901182e-08 578 2.28948602978615 2.50465992217898 1 16.4155816220864 2507 1023 1767 794 2773 1699 2056 2511 578 2184 2800 1959 M14748 GO_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY.html The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. 33/45 Gene Ontology BP GO:0014896 6.07881168551402e-08 4.02645553947883e-07 3645 2215.36363636364 2057 5.5261925940704e-09 413 2.2902813375502 2.5483881190746 1 17.6105114718724 3642 693 1572 1400 413 3955 3551 2833 1886 2367 2057 1960 M15848 GO_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 495/825 Gene Ontology BP GO:0043269 9.46702471093167e-24 1.51896779241259e-21 4225 2260.27272727273 2057 8.60638610084698e-25 14 2.44093628892462 2.70052878332121 1 61.354398663121 4224 1442 14 311 758 3513 4309 3815 2057 73 4347 1961 M10701 GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that modulates the activity of a monooxygenase. 66/91 Gene Ontology BP GO:0032768 9.98703641473402e-08 4.02645553947883e-07 2730 2035.72727272727 2060 9.07912442554703e-09 1001 2.02371435953342 -1.92256104059267 -1 15.5488320194887 2729 1886 1956 1677 1001 2523 1148 2060 3124 2132 2157 1962 M14746 GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. 35/50 Gene Ontology BP GO:0046426 2.58845847383449e-07 5.67775356325191e-07 850 2281.72727272727 2060 2.35314434398666e-08 850 2.62195834573269 3.14247815635283 1 19.7024825302075 850 3717 1871 3891 2060 1287 977 2099 3395 3642 1310 1963 M12663 GO_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a lymphocyte. 106/369 Gene Ontology BP GO:0002449 1.13929431966569e-07 4.06950048332718e-07 2065 1881.18181818182 2061 1.03572216242301e-08 1133 2.13891137791186 -2.15331849617037 -1 16.4278412375094 2061 1836 1361 2394 1182 2115 1566 2233 2589 2223 1133 1964 M10061 GO_L_PHENYLALANINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. 6/12 Gene Ontology BP GO:0006558 7.85062732540128e-08 4.02645553947883e-07 3890 2277.90909090909 2062 7.85062760274687e-09 7 1.87599461155587 -2.47899896037229 -1 14.4063395345514 3886 1270 4222 1518 838 4438 4258 313 7 2245 2062 1965 M15806 GO_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLIC_PROCESS.html The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. 34/78 Gene Ontology BP GO:0019748 1.00020303380183e-06 1.49117100809994e-06 1850 2328.09090909091 2062 9.09275898665609e-08 1582 2.26765856277891 -2.6621712405517 -1 15.876144554728 1847 2537 1582 1945 3081 2567 2908 2062 3335 1925 1820 1966 M16379 GO_SUBPALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBPALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. 27/44 Gene Ontology BP GO:0021544 2.62071479666441e-06 3.43208160677723e-06 1275 1797.72727272727 2062 2.38247083504925e-07 424 2.54291862800341 2.10061577925389 1 16.7023830377982 1272 2062 1378 2485 3520 440 484 2669 2797 2244 424 1967 M13543 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 6/12 Gene Ontology BP GO:1902222 7.85062732540128e-08 4.02645553947883e-07 3890 2293.54545454545 2063 7.85062760274687e-09 8 1.87599461155587 -2.47899896037229 -1 14.4063395345514 3887 1271 4433 1519 839 4439 4259 263 8 2248 2063 1968 M16112 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 6/12 Gene Ontology BP GO:1902221 7.85062732540128e-08 4.02645553947883e-07 3890 2306.72727272727 2064 7.85062760274687e-09 9 1.87599461155587 -2.47899896037229 -1 14.4063395345514 3888 1272 4594 1520 840 4440 4260 238 9 2249 2064 1969 M16398 GO_APOPTOTIC_MITOCHONDRIAL_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_MITOCHONDRIAL_CHANGES.html The morphological and physiological alterations undergone by mitochondria during apoptosis. 76/85 Gene Ontology BP GO:0008637 5.48863481943425e-08 4.02645553947883e-07 2065 2024.54545454545 2064 4.98966814215144e-09 325 1.71379101897018 -2.00282228742708 -1 13.1518262545318 2064 1861 2904 2726 325 2570 3089 1774 912 2930 1115 1970 M16711 GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION.html Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. 21/23 Gene Ontology BP GO:0048070 5.51700755319189e-05 6.01890648182927e-05 2245 1942.90909090909 2064 5.01558719067438e-06 304 3.11593806248933 -2.85336823793982 -1 15.8015385262805 2245 3290 1452 2203 4239 2064 623 804 304 2844 1304 1971 M10978 GO_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 99/130 Gene Ontology BP GO:0009408 1.65596201771547e-07 4.52287618430271e-07 2340 2332.45454545455 2065 1.50542012941945e-08 951 2.1806987962405 2.13340689277601 1 16.6298157781374 2337 3906 1763 2065 1614 1152 951 4649 3758 2285 1177 1972 M16388 GO_L_PHENYLALANINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. 6/12 Gene Ontology BP GO:0006559 7.85062732540128e-08 4.02645553947883e-07 3890 2320.18181818182 2065 7.85062760274687e-09 10 1.87599461155587 -2.47899896037229 -1 14.4063395345514 3889 1273 4620 1521 841 4441 4261 351 10 2250 2065 1973 M13047 GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. 21/22 Gene Ontology BP GO:1903055 1.66242895830252e-07 4.53416292085676e-07 4050 2280 2066 1.51129916720355e-08 564 1.72408293593847 -1.91240010658916 -1 13.1238884280687 4048 923 2208 1397 1620 3036 1683 2919 564 2066 4616 1974 M14284 GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 25/38 Gene Ontology BP GO:0060117 5.52352845596023e-08 4.02645553947883e-07 3345 1944.45454545455 2066 5.02138963149016e-09 332 2.00802353275266 -1.73712363389721 -1 15.4274761958774 3344 2066 2210 1414 332 2491 1502 1069 462 3559 2940 1975 M14805 GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of DNA biosynthetic process. 108/119 Gene Ontology BP GO:2000278 3.6275641789639e-07 7.08090577860156e-07 1005 2125.09090909091 2066 3.29778616100953e-08 559 1.84056181934533 1.95667644703282 1 13.5865635187866 1003 4135 3018 3101 2328 662 559 2066 904 3969 1631 1976 M12901 GO_G1_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage. 88/99 Gene Ontology BP GO:0044783 2.05266208641979e-07 5.00119458251237e-07 1670 2206.27272727273 2067 1.86605661630816e-08 1174 1.92089288684643 2.15545754205078 1 14.5348673239873 1670 2838 2787 3448 1832 1174 1379 2809 1271 2994 2067 1977 M13212 GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. 21/26 Gene Ontology BP GO:0030859 4.6762524832905e-07 8.45651100068041e-07 2275 1700.54545454545 2067 4.25113952478243e-08 14 3.63085011866903 4.35834498353579 1 26.5635986872248 2271 908 884 120 2522 2410 3588 2137 14 2067 1785 1978 M15322 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein. 20/31 Gene Ontology BP GO:0042522 7.61095319172085e-07 1.20701312887107e-06 1700 1938.45454545455 2069 6.91905074977253e-08 434 2.48981804470517 -3.13592284711906 -1 17.7180686861991 1699 3297 2069 828 2890 2278 2049 845 434 2652 2282 1979 M12514 GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM.html Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. 408/924 Gene Ontology BP GO:0098542 3.74841470843299e-07 7.23108359798454e-07 1160 1939.54545454545 2071 3.40765031554306e-08 285 2.30965539103922 -2.28787716432629 -1 17.0500746838993 1159 3118 285 3130 2361 2183 1940 1399 3183 506 2071 1980 M13914 GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. 556/639 Gene Ontology BP GO:0010256 4.25833474130353e-08 4.02645553947883e-07 2485 2085 2071 4.25833482290391e-09 200 1.76854653540573 -1.47368234864025 -1 13.5753157804277 2481 1427 4460 1076 200 2071 1911 3123 1135 2742 2309 1981 M14798 GO_SOMATIC_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_DIVISION.html The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. 32/39 Gene Ontology BP GO:0048103 2.05263447038964e-07 5.00119458251237e-07 3225 2186.90909090909 2072 1.86603151082153e-08 536 1.96329211106983 1.79283764952279 1 14.857963126879 3225 711 2089 1216 1831 2072 2514 4138 536 1351 4373 1982 M14021 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 53/78 Gene Ontology BP GO:0002066 3.28516402215032e-08 3.93734744737334e-07 3350 1869.27272727273 2073 2.98651279200567e-09 82 1.90352407953031 -1.79447583736741 -1 14.6416323099641 3350 427 2073 964 82 2707 2061 2362 666 2562 3308 1983 M14883 GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. 33/44 Gene Ontology BP GO:0038083 1.32572517078974e-07 4.20399283289481e-07 1725 1761.81818181818 2073 1.20520477334387e-08 265 2.05729155212828 -2.17156433442604 -1 15.7619000480959 1725 728 2346 265 1360 2293 2199 943 3085 2073 2363 1984 M10684 GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 95/190 Gene Ontology BP GO:0032649 7.74578548398223e-07 1.22339239161471e-06 1510 1837.09090909091 2074 7.04162564648063e-08 322 1.90045221365579 -1.98124824237376 -1 13.4861919955113 1507 2415 1571 2254 2898 2074 2290 322 2383 1082 1412 1985 M12099 GO_RESPONSE_TO_MAGNESIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MAGNESIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. 25/45 Gene Ontology BP GO:0032026 1.84691774363746e-07 4.77959302622087e-07 3975 2494.72727272727 2074 1.67901627153429e-08 1419 2.60120868530767 -2.70297450954487 -1 19.7810138851229 3971 2074 1419 2010 1715 3845 2697 1990 2392 1969 3360 1986 M16940 GO_REGULATION_OF_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of T cell migration. 18/35 Gene Ontology BP GO:2000404 3.73290779552355e-07 7.21612794872085e-07 1060 2194.36363636364 2074 3.39355311719513e-08 1056 3.09462092546659 -3.09115318515464 -1 22.8831144689132 2074 1056 1057 3174 2356 1878 1143 4449 3016 1531 2404 1987 M14926 GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of keratinocyte differentiation. 36/44 Gene Ontology BP GO:0045616 6.45995051650545e-07 1.07207164843688e-06 1285 1849.45454545455 2075 5.8726840121528e-08 809 2.42536194069763 -2.04211146996011 -1 17.4077466311985 1284 2533 1532 2462 2759 2075 1437 2357 809 2137 959 1988 M15090 GO_REGULATION_OF_CHOLESTEROL_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_STORAGE.html Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 20/23 Gene Ontology BP GO:0010885 2.62543988713479e-07 5.72075198629656e-07 1630 2021.63636363636 2075 2.38676381859096e-08 259 1.98630400399111 -1.50971121769291 -1 14.8930804794019 1627 2631 2554 3212 2075 1206 259 2200 3435 1920 1119 1989 M12033 GO_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_MEDIATED_IMMUNITY.html Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. 57/269 Gene Ontology BP GO:0019724 2.62631535276714e-07 5.72075198629656e-07 3420 2488.36363636364 2076 2.38755969662854e-08 1175 2.37229205410247 -2.8888296972329 -1 17.8071820282859 1876 3472 1531 3418 2076 3027 2029 2031 3418 3319 1175 1990 M12406 GO_COMPLEMENT_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION.html Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. 38/240 Gene Ontology BP GO:0006956 1.01479411502094e-07 4.02645553947883e-07 685 2145 2077 9.22540147118512e-09 654 3.36278298520807 -3.4610052775452 -1 25.9054421721213 684 3230 654 3653 1028 2447 1985 3475 3368 2077 994 1991 M12780 GO_REGULATION_OF_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ORGANIZATION.html Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. 25/33 Gene Ontology BP GO:0090224 6.08404595727746e-08 4.02645553947883e-07 810 1867 2078 5.53095102320931e-09 79 1.24515037420804 -0.940304356117476 -1 9.52727082367434 806 2078 3398 3736 417 425 79 2231 3477 3799 91 1992 M15867 GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 23/28 Gene Ontology BP GO:0048261 3.62159143225164e-07 7.07441852823967e-07 2080 2010.63636363636 2078 3.29235638948196e-08 859 1.45323745675412 -1.03882705856778 -1 10.7064660542922 2078 903 2791 2780 2326 1575 859 2006 2622 2736 1441 1993 M16316 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. 16/23 Gene Ontology BP GO:0002888 2.94860526121778e-06 3.8174346912761e-06 3570 2043.81818181818 2078 2.68055383015223e-07 417 2.40141892642987 -2.49909705800391 -1 15.6330385441687 1572 3567 2078 1838 3569 1309 417 896 2377 2423 2436 1994 M16378 GO_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 268/370 Gene Ontology BP GO:0009612 3.11406276746428e-10 7.20882291393596e-09 2925 1970.09090909091 2078 2.83096615264097e-11 137 2.42653242244202 2.60250095426759 1 23.7912943048608 2924 1594 137 905 1445 2869 4281 3067 2081 290 2078 1995 M11871 GO_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROAUTOPHAGY.html The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. 304/417 Gene Ontology BP GO:0016236 1.06564360533873e-07 4.02645553947883e-07 2080 2271.45454545455 2079 9.68766960869767e-09 892 1.92141830009733 -1.68447750394561 -1 14.757654937585 2079 3123 2738 3654 1095 892 1697 2945 1177 4131 1455 1996 M12754 GO_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. 39/50 Gene Ontology BP GO:0009112 1.77164516013871e-07 4.6864496475983e-07 1790 2452.45454545455 2079 1.61058663891647e-08 1256 1.31637781434077 1.27337635051684 1 9.97320944638382 1789 1971 3454 3738 1679 2029 2755 1256 2517 3710 2079 1997 M11687 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 30/47 Gene Ontology BP GO:0048147 2.74051057245388e-07 5.86280261775996e-07 2080 2068.36363636364 2080 2.49137355803244e-08 207 1.76497688819352 1.979318229752 1 13.1993851720547 2080 2036 2696 2573 2115 1496 2390 1572 207 3729 1858 1998 M12421 GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. 27/47 Gene Ontology BP GO:2001258 1.67445492524189e-07 4.54807218431838e-07 2085 1857.90909090909 2081 1.52223186607939e-08 698 1.78859436215001 1.67062173831566 1 13.6159307447794 2081 782 2372 3218 1627 2157 3066 698 1348 2240 848 1999 M13489 GO_LIPID_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSLOCATION.html The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. 24/30 Gene Ontology BP GO:0034204 4.00950645100668e-06 5.06000366599785e-06 2050 2135.36363636364 2081 3.64501250760235e-07 150 2.67648388814163 -2.27099231405154 -1 17.0393484910416 2050 2081 1777 1329 3661 2370 1503 2665 150 2885 3018 2000 M16700 GO_RESPONSE_TO_MONOAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MONOAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. 53/70 Gene Ontology BP GO:0071867 1.19911859805949e-07 4.10861475461767e-07 2355 1950.72727272727 2082 1.09010787583447e-08 395 1.6917527647708 1.70123840781912 1 12.963429652099 2351 395 2144 1000 1241 2518 4263 2488 2082 1644 1332 2001 M15431 GO_STRIATUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATUM_DEVELOPMENT.html The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. 25/37 Gene Ontology BP GO:0021756 3.66462453748932e-06 4.66270111373743e-06 1890 2186.09090909091 2083 3.33148240164496e-07 693 2.62638592388754 2.14171872791013 1 16.831284072601 1886 2083 1421 2472 3630 883 943 4557 2845 2634 693 2002 M16258 GO_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progress through the mitotic cell cycle. 564/683 Gene Ontology BP GO:0007346 1.43350092720629e-07 4.28944039504236e-07 1565 2420.81818181818 2083 1.43350101967792e-08 992 1.6120466690412 1.81795207994794 1 12.3113454808665 1509 3115 4608 3089 1565 992 1564 2083 2646 3733 1725 2003 M13080 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. 11/18 Gene Ontology BP GO:2000258 8.53715544376308e-06 1.01802625012377e-05 1380 2186.18181818182 2085 7.76108052053628e-07 233 3.07479431399682 -3.26789728588471 -1 18.4614296507357 1378 3841 2085 3395 4139 1638 262 233 3499 3341 237 2004 M14656 GO_ENDOCYTIC_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_RECYCLING.html The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. 29/29 Gene Ontology BP GO:0032456 1.2925292191494e-06 1.84087494848551e-06 645 2086.45454545455 2085 1.17502725320737e-07 499 1.54819196705591 -1.49137892361347 -1 10.6350917232472 642 3251 3230 2903 3233 903 499 2085 1313 3655 1237 2005 M16714 GO_EXTRACELLULAR_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins. 31/36 Gene Ontology BP GO:0043206 6.9143755783231e-05 7.47504404413043e-05 205 2198.45454545455 2085 6.28599354514227e-06 201 2.72010962358144 2.79732444569884 1 13.4715875824002 201 2545 504 1003 4469 2085 3403 3106 4190 1032 1645 2006 M12149 GO_NEGATIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 58/67 Gene Ontology BP GO:0010507 1.93704885249251e-07 4.91487080106452e-07 2090 2104.45454545455 2086 1.76095365731379e-08 140 1.45987864666421 -1.04395124670393 -1 11.0351403367372 2086 398 3238 2808 1752 1881 2628 1433 3377 3408 140 2007 M10286 GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-4 production. 34/68 Gene Ontology BP GO:0032673 1.04332502751137e-05 1.22683632878706e-05 475 2277.45454545455 2087 9.4848179581339e-07 474 1.40672632548463 -1.20471281670899 -1 8.25244569808309 474 1988 2797 2589 3930 1225 1747 1527 3883 2805 2087 2008 M11496 GO_XENOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XENOPHAGY.html The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. 103/157 Gene Ontology BP GO:0098792 3.80188401878969e-07 7.30998609067291e-07 4030 2405.90909090909 2088 3.4562587961859e-08 849 2.75688149867213 2.90830274747862 1 20.3557578369397 4030 2410 849 1701 2371 4648 3768 2023 880 1697 2088 2009 M11800 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 1274/1619 Gene Ontology BP GO:0051130 6.95980156148365e-08 4.02645553947883e-07 2410 2063.81818181818 2088 6.95980177945843e-09 470 2.03227333892365 2.18373334328934 1 15.6150287857704 2406 1325 4324 470 673 2088 3499 2647 1979 620 2671 2010 M11663 GO_CYTOKINETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINETIC_PROCESS.html A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). 18/20 Gene Ontology BP GO:0032506 1.34712910084285e-05 1.55886389112702e-05 2090 2226.36363636364 2089 1.22467031800743e-06 958 1.77488657851485 1.76645519417257 1 10.2158866453958 2089 2657 3043 2061 3993 1450 958 1300 1151 3449 2339 2011 M11122 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 24/27 Gene Ontology BP GO:0010875 4.38308507053235e-06 5.50013345015832e-06 2135 1989.54545454545 2090 3.98463073002458e-07 259 3.11364195875247 3.91971613202443 1 19.7028521911667 2135 2090 1499 798 3684 2549 2950 2577 259 1796 1548 2012 M11242 GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html The directed killing of a target cell by a leukocyte. 34/73 Gene Ontology BP GO:0001909 9.38928897131442e-07 1.42400135539524e-06 2300 2211.72727272727 2090 8.53572088957509e-08 1535 1.64238250514511 -1.26841315252313 -1 11.5098837748409 2296 2003 2739 2418 3031 2090 1925 1754 1535 2478 2060 2013 M10249 GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT.html The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. 147/195 Gene Ontology BP GO:0061008 8.17571057265079e-08 4.02645553947883e-07 2030 2058.36363636364 2092 7.43246443316289e-09 767 1.78267553291867 -1.69308603767245 -1 13.6845921209254 2030 1793 2487 1831 767 2609 1247 2092 2702 2320 2764 2014 M12649 GO_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASOCONSTRICTION.html A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure. 22/39 Gene Ontology BP GO:0042310 4.19108663936596e-06 5.27627871563036e-06 2805 2040.54545454545 2092 3.81008602142941e-07 368 3.69215215768097 4.53952863604241 1 23.4633213933631 2803 2092 368 1486 3670 2953 3119 2744 960 1474 777 2015 M16521 GO_MONOAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOAMINE_TRANSPORT.html The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/24 Gene Ontology BP GO:0015844 1.61201281851509e-05 1.84928393603322e-05 3800 2208 2092 1.46547693671614e-06 281 2.79483354749835 -2.29591992394244 -1 15.8948742025743 3800 2710 1714 1114 4055 4196 3507 307 512 2092 281 2016 M11125 GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. 63/118 Gene Ontology BP GO:0045824 2.47567486000149e-06 3.25496330138088e-06 290 2079.63636363636 2094 2.25061604172684e-07 290 1.67452566493907 -1.35487230465583 -1 11.0100521475935 290 349 2220 3464 3505 1223 1293 1907 4278 2094 2253 2017 M16828 GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION.html Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. 24/26 Gene Ontology BP GO:2000615 5.92276612561789e-06 7.25227125855264e-06 1795 2328.36363636364 2094 5.38434733704552e-07 851 1.31029863218728 1.47875387120033 1 8.04150345415732 1793 2094 3199 2802 3770 1370 1843 851 3039 3187 1664 2018 M10186 GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 70/102 Gene Ontology BP GO:0070373 4.90013742416029e-08 4.02645553947883e-07 3455 2039.90909090909 2095 4.4546704848207e-09 237 1.81692133627682 1.87010678098843 1 13.949455644679 3451 285 2120 1411 237 1962 3190 2615 2095 2052 3021 2019 M11460 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 45/65 Gene Ontology BP GO:0010765 3.24950317747642e-07 6.6112541691289e-07 3140 2001.09090909091 2095 2.95409423403943e-08 474 2.33809386923778 2.55452380282654 1 17.3713298286998 3137 474 1017 900 2231 2203 2095 3086 1146 1513 4210 2020 M16271 GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 20/27 Gene Ontology BP GO:0042454 1.41823509485992e-06 1.9930679240058e-06 1660 2250.90909090909 2095 1.2893054628448e-07 549 2.16037220488951 2.3857613724819 1 14.790956727464 1656 3298 2190 4112 3280 2040 1460 549 1799 2281 2095 2021 M10996 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. 43/51 Gene Ontology BP GO:1900077 3.34650836265942e-07 6.74374335706118e-07 2745 2031.90909090909 2096 3.04228079246396e-08 554 1.96110156990273 -1.73802841757908 -1 14.5333525049552 2742 554 1964 1597 2254 2003 1037 2373 2306 2096 3425 2022 M12594 GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 184/241 Gene Ontology BP GO:0071453 1.00023219918013e-07 4.02645553947883e-07 2185 2266.81818181818 2096 9.0930204059617e-09 1003 2.08324385224195 2.35607564437127 1 16.009244381294 2184 3642 1635 1875 1003 1297 2758 4181 1714 2550 2096 2023 M12821 GO_REGULATION_OF_STEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of steroid hormone secretion. 15/30 Gene Ontology BP GO:2000831 5.01693571971996e-07 8.86922564736206e-07 1185 1895.45454545455 2096 4.56085169435914e-08 407 2.07319490093974 -1.96016606498523 -1 15.0716076457129 1184 3339 2181 2096 2585 1238 478 407 3056 2670 1616 2024 M14411 GO_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. 43/46 Gene Ontology BP GO:0097581 4.71739611431443e-08 4.02645553947883e-07 4465 2256.90909090909 2097 4.28854201406198e-09 208 1.83902265005443 1.87807648358905 1 14.1203913878269 4465 495 1915 1503 208 3746 4158 2590 773 2097 2876 2025 M14516 GO_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPOLYMERIZATION.html The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. 35/40 Gene Ontology BP GO:0051261 6.08277102323083e-08 4.02645553947883e-07 2410 1778.72727272727 2097 5.52979199219377e-09 415 2.31384810232073 2.49147032478021 1 17.7927812903175 2410 687 1669 1094 415 2097 2255 2274 2302 2028 2335 2026 M10241 GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 18/21 Gene Ontology BP GO:0051532 1.52014942345235e-07 4.38336566905022e-07 2465 2060 2101 1.38195411681017e-08 605 1.40191841570338 -1.7639583962832 -1 10.6772072250992 2462 2653 3281 1879 1517 2101 1094 605 2148 3774 1146 2027 M11530 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 28/35 Gene Ontology BP GO:0043243 3.13496792032904e-08 3.84881417764934e-07 2800 2092 2101 2.84997087727442e-09 73 2.26503575786724 2.30251822461059 1 17.4689371591695 2797 2057 2122 1355 73 2649 3922 1659 1237 3040 2101 2028 M16209 GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. 53/70 Gene Ontology BP GO:2000677 4.32258922938725e-05 4.76047519155949e-05 125 1778.45454545455 2101 3.92970378411911e-06 121 1.71911211697444 -1.83056509983573 -1 8.88359460431347 121 2869 2227 3012 4197 405 281 486 3621 2101 243 2029 M12005 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 84/100 Gene Ontology BP GO:0010595 2.69959004153507e-07 5.80998726330373e-07 2740 1969.90909090909 2102 2.45417306618013e-08 183 2.16744993969155 1.93277193161177 1 16.2430609096865 2738 183 1144 600 2102 2211 2220 3374 1651 1261 4185 2030 M16480 GO_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 263/439 Gene Ontology BP GO:0009615 2.70178299217594e-07 5.81201861423701e-07 1310 2221.90909090909 2103 2.45616665816129e-08 1084 2.07131520478402 -2.07255792497018 -1 15.5176718517003 1309 3635 1448 3416 2103 2117 1963 1991 3167 1084 2208 2031 M14188 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 130/153 Gene Ontology BP GO:0007179 9.65197215629586e-07 1.45200861439524e-06 1080 2167.72727272727 2104 8.7745239916997e-08 687 1.86248840490743 2.08440965077903 1 13.0471396107885 1076 2821 2065 1854 3057 1367 3596 2120 3098 2104 687 2032 M11081 GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY.html The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. 21/35 Gene Ontology BP GO:0007250 3.16617758048721e-06 4.07981841096842e-06 1200 2163.18181818182 2105 2.87834739742666e-07 851 2.02618562784722 -1.94185162446897 -1 13.1034701956104 1200 2142 2557 2105 3587 851 939 3975 3503 2065 871 2033 M10118 GO_ACYLGLYCEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. 19/41 Gene Ontology BP GO:0055090 6.58350158301043e-06 7.97527541414932e-06 290 2035.81818181818 2108 5.98501934929654e-07 213 1.56231658909236 -1.63423004257111 -1 9.52999759154046 286 3311 3056 3514 4628 321 360 213 4083 2108 514 2034 M13481 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE.html The directed movement of a protein to a specific location in a membrane. 317/432 Gene Ontology BP GO:0090150 4.43599573199498e-08 4.02645553947883e-07 570 2108.72727272727 2108 4.03272347403702e-09 174 1.52796257934494 -1.2893025520346 -1 11.7145939368072 569 3880 4074 3354 174 556 378 2108 2450 4483 1170 2035 M15078 GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. 17/18 Gene Ontology BP GO:1904152 1.03006499936424e-05 1.21216298483606e-05 935 2066.09090909091 2108 9.36427111161115e-07 352 1.40503469162081 -1.27606299874192 -1 8.25127764763088 933 2660 3323 2108 3926 1200 352 2948 762 3378 1137 2036 M12013 GO_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. 34/47 Gene Ontology BP GO:0046513 2.46242880567988e-07 5.55120214768822e-07 4080 2369.81818181818 2109 2.23857189208736e-08 652 2.29545884554884 -2.18932930895406 -1 17.2633858705016 4077 652 1521 2168 2001 3439 3576 2109 950 925 4650 2037 M12740 GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 23/55 Gene Ontology BP GO:0032689 1.46660124122688e-07 4.35210177004379e-07 4235 2647.18181818182 2109 1.33327394454176e-08 1470 2.2560818737687 1.7009191659282 1 17.253848183815 4232 2089 1598 1572 1470 4588 3699 2709 2109 1658 3395 2038 M11476 GO_MALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GAMETE_GENERATION.html Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. 416/832 Gene Ontology BP GO:0048232 2.20371690667798e-07 5.17090003367254e-07 1790 2308.36363636364 2110 2.00337920674729e-08 1136 1.7816407474704 1.92609742532226 1 13.4424940597249 1790 3628 3100 3875 1915 1445 2110 1354 2818 2221 1136 2039 M11653 GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. 41/52 Gene Ontology BP GO:0008154 5.20739639182733e-08 4.02645553947883e-07 4170 2533.81818181818 2110 4.73399683189664e-09 269 2.17194357352177 -2.18374809462453 -1 16.6952648109635 4168 583 1963 1116 269 4623 3610 2983 2110 1886 4561 2040 M11593 GO_TRIGLYCERIDE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. 19/41 Gene Ontology BP GO:0070328 1.31411838605055e-05 1.5229371980805e-05 290 2043.36363636364 2111 1.19466021426733e-06 284 1.56231658909236 -1.63423004257111 -1 8.99917925107334 287 3312 3057 3515 4629 322 361 284 4084 2111 515 2041 M11332 GO_GANGLIOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 20/27 Gene Ontology BP GO:0001573 2.54853915288896e-07 5.65745344301423e-07 3045 2142.81818181818 2113 2.31685404374421e-08 727 2.17237792420579 -1.79611452871415 -1 16.3105817071894 3041 2113 1414 2185 2036 4003 1974 1188 2380 727 2510 2042 M12589 GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. 19/36 Gene Ontology BP GO:0042088 1.25244855799701e-06 1.79312096626465e-06 415 1669.45454545455 2113 1.13859024637276e-07 256 1.71882325422032 -1.86676120813771 -1 11.8422953851904 412 2150 2377 2549 3210 592 256 524 2884 2113 1297 2043 M15755 GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. 22/24 Gene Ontology BP GO:1904666 7.03798287741811e-07 1.13500528055764e-06 1915 1939.63636363636 2115 6.39816829902577e-08 409 1.76257995401127 2.20379346034605 1 12.5697625113169 1912 2115 2720 2512 2841 1227 409 2721 1001 2963 915 2044 M10858 GO_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. 934/1187 Gene Ontology BP GO:0007010 6.02155767731178e-08 4.02645553947883e-07 2465 2036.18181818182 2117 6.021557840478e-09 182 1.99741598830532 2.25253949165076 1 15.3454354397791 2464 1353 4266 1887 571 2439 3428 2117 1349 182 2342 2045 M10341 GO_PINOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PINOCYTOSIS.html An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. 21/23 Gene Ontology BP GO:0006907 1.26674341121232e-05 1.47317098034765e-05 1570 2306.54545454545 2118 1.15159155007651e-06 667 1.40218435424196 -1.57373406536477 -1 8.09070898671666 1566 2118 3109 2933 3973 2110 1407 667 2613 2830 2046 2046 M12438 GO_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 142/203 Gene Ontology BP GO:0043279 5.33539790963109e-08 4.02645553947883e-07 3230 1952 2118 4.85036185365829e-09 296 2.27970720262212 2.48075639343873 1 17.5287291113184 3227 1780 395 567 296 3763 4068 2118 2624 371 2263 2047 M16057 GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT.html The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. 17/21 Gene Ontology BP GO:0060525 7.37578737604317e-07 1.17509377491192e-06 4430 2241.45454545455 2118 6.70526349897581e-08 39 2.67775717719522 -1.95453770557979 -1 19.1009487359874 4429 972 1249 260 2878 3537 3706 3716 39 1752 2118 2048 M16489 GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. 19/25 Gene Ontology BP GO:0072525 6.26581924037507e-07 1.04722905623079e-06 1755 2053.90909090909 2118 5.69620093176686e-08 410 1.9411855708785 -2.19890586126289 -1 13.9359790671752 1751 993 2420 3372 2742 2136 1894 1469 3288 2118 410 2049 M14085 GO_RESPONSE_TO_AMINO_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINO_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 146/177 Gene Ontology BP GO:0043200 1.94183498593001e-07 4.9212190574795e-07 2645 2146.72727272727 2119 1.76530468847867e-08 912 2.23690168253126 -2.18746930376547 -1 16.9618965367428 2641 2814 912 1632 1755 2416 1184 3277 1997 2119 2867 2050 M10499 GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the rate of skeletal muscle tissue development. 27/40 Gene Ontology BP GO:0048643 1.56581875710829e-07 4.41807401483567e-07 3265 1939.27272727273 2120 1.42347169868476e-08 254 1.7984651049765 -1.38584449248574 -1 13.7190348617722 3261 786 2375 254 1560 3084 2120 4421 308 2239 924 2051 M15952 GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT.html The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. 18/23 Gene Ontology BP GO:0060841 6.63461888426087e-06 8.02883788516666e-06 3175 2177.72727272727 2120 6.03148990236673e-07 524 2.82261229252638 2.82321561566194 1 17.290824504868 3173 2120 686 1115 3818 2482 3339 1623 1269 524 3806 2052 M16616 GO_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_BACTERIUM.html Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. 160/539 Gene Ontology BP GO:0042742 1.00658657655672e-07 4.02645553947883e-07 1070 1956 2120 9.15078747829104e-09 251 2.51261305784804 -2.56403365361766 -1 19.3300670700994 1068 3430 251 2658 2089 2120 2309 1481 3349 496 2265 2053 M11045 GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. 14/21 Gene Ontology BP GO:0003323 4.51200045852331e-06 5.64971424475483e-06 2455 1834.90909090909 2121 4.10182701113962e-07 26 2.20360297303546 -2.31677854402219 -1 13.8830573483971 2452 1090 2121 154 3691 2102 920 2443 26 2484 2701 2054 M10534 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS.html Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 16/17 Gene Ontology BP GO:0010561 7.99432027241919e-07 1.25709943317224e-06 2125 2106.27272727273 2124 7.26756652489302e-08 724 1.7739156693381 -1.30806368021811 -1 12.5560710590853 2124 2678 2889 2487 2914 2076 724 778 2063 2863 1573 2055 M12384 GO_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that modulates the frequency, rate, or extent of a homeostatic process. 468/664 Gene Ontology BP GO:0032844 7.35621643100351e-08 4.02645553947883e-07 3020 2132.27272727273 2125 6.68746970634171e-09 239 2.15434807672592 2.20145357945689 1 16.5591779090209 3020 1466 239 694 1325 2556 3789 4455 2125 332 3454 2056 M16028 GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of embryonic development. 31/48 Gene Ontology BP GO:0040019 1.20889185834974e-07 4.11483088288319e-07 3440 2193.27272727273 2125 1.098992658889e-08 970 2.47121836609963 3.05559433909102 1 18.9817321332824 3440 2927 1699 2304 1251 3935 2550 970 1752 2125 1173 2057 M10957 GO_SPHINGOMYELIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOMYELIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. 13/14 Gene Ontology BP GO:0006684 5.64877423266247e-06 6.95009432879731e-06 425 1733.27272727273 2126 5.13526248786053e-07 180 1.85100955100507 -1.85100955100507 -1 11.4437929302103 423 3053 2905 2474 3755 530 180 386 2126 2776 458 2058 M15621 GO_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_P38MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of p38MAPK cascade. 38/45 Gene Ontology BP GO:1900744 2.35450420594748e-07 5.3972042302237e-07 3865 2507.09090909091 2127 2.1404585981213e-08 626 2.03683513062958 2.32764648044516 1 15.336860141161 3865 626 1613 1182 1965 3363 4430 3081 2127 911 4415 2059 M14138 GO_REGULATION_OF_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. 17/19 Gene Ontology BP GO:0033127 0.000114443090563139 0.000121993974888954 2130 2383 2128 1.04044585708181e-05 807 2.42914941877368 3.16953355612926 1 11.3946241124637 2128 3333 2996 2137 4337 2052 1471 1782 1247 3923 807 2060 M15435 GO_CELLULAR_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. 491/767 Gene Ontology BP GO:0055082 3.86158300311962e-10 8.63843543919018e-09 2225 1695.72727272727 2128 3.5105300034522e-11 141 2.17999477816064 -2.00648824432684 -1 21.1564689257004 3075 1454 141 1242 341 2222 2224 2742 2128 157 2927 2061 M15792 GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that activates or increases the activity of a monooxygenase. 27/35 Gene Ontology BP GO:0032770 6.21124849963543e-07 1.04110011775229e-06 2130 2262.81818181818 2128 5.64659113932243e-08 814 1.97814023637466 -2.16091258973845 -1 14.2093391611634 3854 814 2128 1213 2734 3835 1908 2130 857 1937 3481 2062 M16685 GO_GLYCOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. 17/26 Gene Ontology BP GO:0016137 8.7421246365411e-06 1.04113401417522e-05 825 2380.36363636364 2128 7.94741761386724e-07 824 1.88314042696224 -2.09654068252783 -1 11.2444965864279 824 3024 2895 2128 3881 1926 1713 835 3441 3924 1593 2063 M11364 GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. 20/25 Gene Ontology BP GO:0050774 8.03117820145587e-06 9.59904242778684e-06 2275 1962.72727272727 2129 7.30109774518837e-07 353 1.90075713112978 -1.68685733318315 -1 11.4317492674086 2272 2129 2582 800 3867 2547 1496 1676 814 3054 353 2064 M12844 GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that activates or increases the activity of a phosphoprotein phosphatase. 20/27 Gene Ontology BP GO:0032516 2.79838198290548e-07 5.95298733682208e-07 1570 2393 2129 2.54398394441585e-08 1142 1.60414742024681 1.84178361745707 1 11.9743777680544 1570 2161 2922 4135 2129 1912 1842 1280 3844 3386 1142 2065 M15335 GO_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERTILIZATION.html The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). 107/221 Gene Ontology BP GO:0009566 2.18781960984992e-07 5.15590364235942e-07 2670 2340.36363636364 2129 1.98892711583692e-08 1725 2.21256672776785 -2.27526429886406 -1 16.7221117612652 2667 2408 1953 1968 1905 3299 3408 1725 1869 2129 2413 2066 M12561 GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 21/50 Gene Ontology BP GO:0071378 1.19260695016143e-05 1.39112563025849e-05 475 2305 2133 1.08419401387457e-06 271 1.67678558848625 -1.77329896657186 -1 9.74580973965473 471 4244 3234 3600 4279 921 811 271 2133 4122 1269 2067 M16308 GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 40/46 Gene Ontology BP GO:0060444 0.000268893927041154 0.0002821748855486 2135 2388.81818181818 2134 2.44478907359173e-05 1280 2.40908551250637 2.8128096295213 1 10.2386046796107 2134 3947 1771 1880 4414 1495 2150 3191 1450 2565 1280 2068 M12025 GO_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENTATION.html The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. 87/105 Gene Ontology BP GO:0043473 2.82136607402709e-07 5.98350790448863e-07 1030 2195.90909090909 2135 2.56487857804561e-08 1028 1.96914724848038 -1.68209157380841 -1 14.717106350969 1616 2840 2634 3873 2135 1028 1455 1998 2434 3113 1029 2069 M11058 GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a type 2 immune response. 17/45 Gene Ontology BP GO:0002828 3.0298188857961e-06 3.91169458257748e-06 495 2147.18181818182 2136 2.7543845985833e-07 491 2.34202554232825 -2.39532294722855 -1 15.2138411656935 491 3020 2136 2976 3579 1318 1690 1905 2649 2179 1676 2070 M11631 GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that activates or increases the rate of neuroblast proliferation. 24/33 Gene Ontology BP GO:0002052 1.63237662358138e-07 4.49700913530147e-07 3065 2133.45454545455 2136 1.48397885882001e-08 749 1.64895740837391 1.76849102830647 1 12.5546653765394 3062 873 2319 1221 1602 3180 3690 1656 2136 749 2980 2071 M10045 GO_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_RHYTHM.html Any biological process in an organism that recurs with a regularity of approximately 24 hours. 143/192 Gene Ontology BP GO:0007623 1.55622787940547e-07 4.41300019561337e-07 3145 2520.63636363636 2137 1.4147527177176e-08 1493 2.11836938004949 -1.79178001815184 -1 16.1789179577989 3143 2817 1717 2005 1548 2758 2137 4490 1889 1493 3730 2072 M15388 GO_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_SECRETION.html Any process that modulates the frequency, rate, or extent of peptide secretion. 224/327 Gene Ontology BP GO:0002791 4.93657842379798e-08 4.02645553947883e-07 245 1908.81818181818 2138 4.48779866779077e-09 77 2.16306041994442 2.21847137050512 1 16.6265608201727 2900 1627 370 77 241 2155 3916 3717 2138 245 3611 2073 M14855 GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 28/30 Gene Ontology BP GO:0032878 2.96245320697684e-08 3.74573227501718e-07 1135 2378.63636363636 2139 2.69313931533485e-09 63 1.71545499784578 -1.74211415357116 -1 13.2298116342851 1135 4218 3290 4007 63 2139 1316 975 3903 3552 1567 2074 M10423 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN.html The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. 10/27 Gene Ontology BP GO:0001991 2.09299345826481e-08 3.10149635710387e-07 3865 2420.27272727273 2140 1.90272134379702e-09 15 1.94756716809775 1.68444762799501 1 15.2268816890701 3862 1193 1881 2387 15 4146 2048 3710 988 2140 4253 2075 M11757 GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of phospholipid metabolic process. 79/120 Gene Ontology BP GO:1903725 9.67659483085869e-08 4.02645553947883e-07 4030 2536.09090909091 2140 8.79690477861738e-09 965 1.86391728568315 -1.76448475353404 -1 14.3129312107718 4026 1853 1762 2140 965 3489 2635 3833 1944 1247 4003 2076 M12466 GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. 45/50 Gene Ontology BP GO:0001953 2.83778872609344e-07 6.00192315568764e-07 1745 2324 2141 2.57980826558273e-08 1555 2.30056681876644 2.05787318571853 1 17.2077009760658 1745 1955 1555 2022 2141 1618 2560 3596 2784 2545 3043 2077 M16437 GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. 10/15 Gene Ontology BP GO:1900121 1.68420028298667e-07 4.55820858027515e-07 3475 2313.09090909091 2141 1.53109128356354e-08 1228 2.05207650823899 2.54735363862752 1 15.6344937859165 3471 1228 2060 1530 1634 2946 2141 3419 2919 1624 2472 2078 M15972 GO_MATERNAL_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PLACENTA_DEVELOPMENT.html Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 33/41 Gene Ontology BP GO:0001893 1.14413949120008e-06 1.66157336222034e-06 1730 1981.36363636364 2143 1.04012735111417e-07 320 2.09403050744917 -2.55709047129646 -1 14.5336628002387 1728 2908 2385 2484 3172 2143 1633 320 705 3509 808 2079 M11702 GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND.html A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. 34/47 Gene Ontology BP GO:0001702 1.44857843948796e-06 2.03080309699834e-06 1980 2395 2145 1.31689035754337e-07 1246 2.01993914964795 2.43589428658427 1 13.8028919415028 1977 2910 2145 3772 3288 2031 1733 1492 3271 2480 1246 2080 M12070 GO_POSITIVE_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASODILATION.html Any process that activates or increases the frequency, rate or extent of vasodilation. 27/43 Gene Ontology BP GO:0045909 4.43642173542227e-07 8.17531498412666e-07 2530 1781.45454545455 2146 4.03311148186501e-08 521 2.5353963456243 2.45779171849332 1 18.5631394179082 2529 785 707 521 2475 2252 3463 2146 2681 1052 985 2081 M16599 GO_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 193/278 Gene Ontology BP GO:0030098 1.35790877584224e-07 4.23886744058351e-07 2610 2125.27272727273 2147 1.23446259968784e-08 601 2.19050574350491 -2.00786187389861 -1 16.7796798326609 2608 1690 736 765 1387 3125 2519 4559 2147 601 3241 2082 M10304 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. 20/25 Gene Ontology BP GO:1900015 6.43298803482869e-08 4.02645553947883e-07 2265 1936.45454545455 2148 5.84817111175888e-09 471 2.69075472024099 -2.39775891985437 -1 20.7078483980849 2262 2148 1140 1569 471 2833 3177 2365 3298 943 1095 2083 M11292 GO_HORMONE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_TRANSPORT.html The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 72/118 Gene Ontology BP GO:0009914 1.05645841817502e-07 4.02645553947883e-07 2870 1840.09090909091 2149 9.60416789915492e-09 251 2.31593541284314 -2.42512999390703 -1 17.8089249448947 2869 251 734 1075 1083 2898 2266 2856 2149 1103 2957 2084 M16433 GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION.html The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. 18/22 Gene Ontology BP GO:0060900 3.55303081097618e-07 6.991790307027e-07 3880 2570.45454545455 2149 3.23002853163251e-08 900 2.29081963059438 -2.1502782092956 -1 16.9506788232656 3876 2149 1518 2043 2308 4507 3670 1806 3539 1959 900 2085 M10758 GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 102/128 Gene Ontology BP GO:0006661 3.26577180217456e-06 4.20117119035616e-06 1200 2574.18181818182 2151 2.96888786366597e-07 986 1.35381744698618 -1.3537826477384 -1 8.7002152031918 1196 3171 3858 4012 3593 1083 1850 2071 2151 4345 986 2086 M11843 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). 446/684 Gene Ontology BP GO:0032787 8.0984109957335e-08 4.02645553947883e-07 1610 1952.18181818182 2151 7.36219208531255e-09 752 1.9613390542186 -1.94055267913736 -1 15.0664096044526 1607 2337 1200 1890 752 2151 2190 2787 2359 1537 2664 2087 M12464 GO_L_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_IMPORT.html The directed movement of L-enantiomer amino acids into a cell or organelle. 10/23 Gene Ontology BP GO:0043092 6.00366014842336e-07 1.01484919564643e-06 4545 2423.09090909091 2151 5.45787435162244e-08 474 2.69470877174017 2.07613670929634 1 19.4300215990519 4545 1216 1352 1931 2710 4603 2440 1517 474 2151 3715 2088 M14750 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. 28/30 Gene Ontology BP GO:1904376 2.9007945541776e-07 6.09914010871594e-07 840 2549 2152 2.63708630605445e-08 836 1.15940269043514 -1.25950915454775 -1 8.61120513886571 836 2946 3626 4504 2152 1816 916 1938 4254 3296 1755 2089 M10645 GO_STEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. 55/94 Gene Ontology BP GO:0055092 3.13338119575364e-07 6.4340788631252e-07 3910 2395.54545454545 2153 2.84852876548181e-08 888 2.52689427620401 3.00211431411663 1 18.818426832669 3909 1898 1191 1556 2204 3411 4441 1649 2153 888 3051 2090 M16531 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. 28/30 Gene Ontology BP GO:1903077 2.9007945541776e-07 6.09914010871594e-07 840 2546.81818181818 2153 2.63708630605445e-08 837 1.15940269043514 -1.25950915454775 -1 8.61120513886571 837 2947 3627 4505 2153 1817 917 1904 4255 3297 1756 2091 M13144 GO_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. 55/94 Gene Ontology BP GO:0042632 3.13338119575364e-07 6.4340788631252e-07 3910 2366 2154 2.84852876548181e-08 889 2.52689427620401 3.00211431411663 1 18.818426832669 3910 1899 1192 1557 2205 3412 4442 1314 2154 889 3052 2092 M16266 GO_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other 765/1247 Gene Ontology BP GO:0055085 3.16516191662855e-09 5.82114561188641e-08 2705 2157.36363636364 2155 3.16516192113676e-10 142 2.282751363574 -2.18971095912415 -1 19.8710699143302 2701 1384 4610 2155 982 3191 2924 1368 1486 142 2788 2093 M12565 GO_ORGANELLE_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FISSION.html The creation of two or more organelles by division of one organelle. 529/735 Gene Ontology BP GO:0048285 2.64607639640052e-07 5.73520453692257e-07 170 1795.09090909091 2156 2.64607671147798e-08 170 1.59345561752228 1.7993657616832 1 11.925073593033 170 2767 4375 2854 2156 346 462 900 2493 2209 1014 2094 M11869 GO_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORT.html The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 568/954 Gene Ontology BP GO:0006812 6.94859494057663e-10 1.48311065405977e-08 2440 1991.18181818182 2157 6.94859494274935e-11 127 2.23326392876171 -2.14728154129258 -1 21.041946630675 2436 1415 4329 2157 381 2395 2387 1933 1556 127 2787 2095 M15081 GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION.html Any process that activates or increases the frequency, rate or extent of dendrite extension. 17/29 Gene Ontology BP GO:1903861 5.01006409148451e-07 8.86381301052373e-07 2350 1934.90909090909 2157 4.55460475675246e-08 58 2.31707415490043 -2.32606373940014 -1 16.857403057808 2347 2176 2157 1280 2582 2929 2070 1457 58 2596 1632 2096 M10942 GO_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. 39/56 Gene Ontology BP GO:0046632 2.94119243351115e-07 6.16180476953057e-07 1350 2141.27272727273 2158 2.67381166065537e-08 1044 2.10167508014375 -1.71540341931499 -1 15.6821157505861 1348 2523 2014 2917 2163 2158 1752 1044 3555 1394 2686 2097 M11035 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. 23/36 Gene Ontology BP GO:0045686 2.04389415778715e-07 5.00012592859286e-07 2065 2195.90909090909 2158 1.85808577061245e-08 1670 2.37599743913829 -1.68859254706625 -1 18.003177910435 2417 2613 2063 1872 1827 2579 2064 2536 1670 2356 2158 2098 M14528 GO_MITOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_RECOMBINATION.html The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. 41/43 Gene Ontology BP GO:0006312 3.53504739516751e-05 3.92193026459571e-05 45 1895.72727272727 2158 3.213731089992e-06 35 1.32797114008487 1.37060368949948 1 6.97407868020452 42 2515 3373 2453 4170 201 35 982 3602 2158 1322 2099 M15666 GO_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_EXTENSION.html Any process that modulates the frequency, rate or extent of dendrite extension. 17/29 Gene Ontology BP GO:1903859 5.01006409148451e-07 8.86381301052373e-07 2350 1938.36363636364 2158 4.55460475675246e-08 59 2.31707415490043 -2.32606373940014 -1 16.857403057808 2348 2177 2158 1281 2583 2930 2071 1485 59 2597 1633 2100 M11700 GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. 17/33 Gene Ontology BP GO:0002675 4.24730591663164e-05 4.68199820660674e-05 965 2677.45454545455 2159 3.86126174278556e-06 964 2.62307670179115 -3.12398254642719 -1 13.6319149718665 964 4272 1851 3921 4193 2159 1357 1290 4447 3007 1991 2101 M10060 GO_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSPORT.html The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 80/175 Gene Ontology BP GO:0006813 1.54030260235413e-09 3.08923621066973e-08 2880 1739.63636363636 2160 1.40027509402959e-10 149 2.64474589190547 2.83606514707185 1 23.9186187875753 2876 149 163 2160 1608 2024 2838 2394 2267 183 2474 2102 M13603 GO_PARTURITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARTURITION.html The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. 13/26 Gene Ontology BP GO:0007567 2.21285397478874e-05 2.49549431524286e-05 2105 2079 2160 2.01170566630245e-06 956 2.92284027667192 -3.78245897759562 -1 16.1675195227626 2104 2247 1436 1999 4104 2160 1010 2218 956 2299 2336 2103 M15797 GO_ADENOHYPOPHYSIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOHYPOPHYSIS_DEVELOPMENT.html The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. 6/17 Gene Ontology BP GO:0021984 4.18460575190759e-07 7.85119780791371e-07 2160 1980.63636363636 2160 4.18460653989943e-08 397 3.18429860566494 -2.36386435826439 -1 23.4081462384044 2160 2308 4573 1532 2505 2633 725 397 1393 963 2598 2104 M12706 GO_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_REMODELING.html The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. 61/78 Gene Ontology BP GO:0046849 2.93453935371856e-07 6.1534076669006e-07 3280 2298.54545454545 2161 2.6677634046831e-08 340 2.11480783317444 2.40332427076502 1 15.7822668126211 3279 340 1121 1181 2161 4000 4535 2192 3724 1132 1619 2105 M10390 GO_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 49/68 Gene Ontology BP GO:0010043 4.91613530220768e-07 8.74083972532378e-07 3135 1984.09090909091 2163 4.46921490979184e-08 132 3.2344045261235 -3.4287148519004 -1 23.5957489833128 3132 1910 688 378 2571 3559 2163 2947 132 1458 2887 2106 M11875 GO_MEMBRANE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DOCKING.html The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. 69/78 Gene Ontology BP GO:0022406 8.3204715003529e-08 4.02645553947883e-07 840 2248.09090909091 2163 7.56406528639625e-09 544 1.4330467361674 -1.05296917225774 -1 10.9804968440589 838 3194 3476 3453 785 1291 544 1726 3243 4016 2163 2107 M10051 GO_GLUCURONATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. 9/28 Gene Ontology BP GO:0019585 1.14867102606294e-06 1.66565113188054e-06 3140 2098.72727272727 2164 1.14867161981368e-07 138 3.21501739555785 -2.86908660336094 -1 22.3648726550049 3138 1236 4220 458 3217 2164 717 2940 138 3022 1836 2108 M10893 GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. 6/48 Gene Ontology BP GO:0042738 5.1220792258528e-06 6.35547590343816e-06 1710 2386 2165 5.12209103195412e-07 962 3.48470974820736 -3.78118390143256 -1 21.7986482290662 1706 2310 4269 2016 3754 2196 2165 1543 3876 962 1449 2109 M11169 GO_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORT.html A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 172/301 Gene Ontology BP GO:0098656 2.94449607132416e-07 6.16317598734651e-07 4250 2453.54545454545 2165 2.67681496856158e-08 356 2.32478930621204 2.30559590936357 1 17.3575904612002 4250 1710 356 1691 2165 4551 3753 3171 704 555 4083 2110 M14004 GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. 87/125 Gene Ontology BP GO:0060333 1.49320274277068e-06 2.08394491964966e-06 295 1915.81818181818 2165 1.35745796022812e-07 291 1.86050174846592 -1.7282130607505 -1 12.6800360037445 291 2427 1774 2413 3302 1135 1061 2574 2921 1011 2165 2111 M14675 GO_URONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. 9/28 Gene Ontology BP GO:0006063 1.14867102606294e-06 1.66565113188054e-06 3140 2129.36363636364 2165 1.14867161981368e-07 139 3.21501739555785 -2.86908660336094 -1 22.3648726550049 3139 1237 4510 459 3218 2165 718 2968 139 3033 1837 2112 M15689 GO_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTOSIS.html A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells. 318/474 Gene Ontology BP GO:0006887 1.07493499778958e-07 4.02645553947883e-07 2865 2085.72727272727 2165 9.77213682101485e-09 625 2.10342861892474 -1.98674086625122 -1 16.1653571865285 2863 1548 625 2165 1108 2866 1993 3449 2554 1319 2453 2113 M11621 GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). 48/58 Gene Ontology BP GO:0007223 9.45017215745653e-07 1.43198214268385e-06 1570 2225.45454545455 2166 8.59106928801039e-08 664 1.62357930856709 1.84345498561173 1 11.3721655341879 1569 1935 3217 2600 3034 989 2166 1420 3357 3529 664 2114 M14586 GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. 16/27 Gene Ontology BP GO:0051580 8.76195895016284e-06 1.04296226643918e-05 1835 2355.81818181818 2166 7.96544895153345e-07 292 1.79784620903117 -1.92538187687082 -1 10.7288727342981 1831 3795 2166 3003 3883 1728 292 2636 4395 913 1272 2115 M16166 GO_EPOXYGENASE_P450_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPOXYGENASE_P450_PATHWAY.html The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. 9/57 Gene Ontology BP GO:0019373 4.25383698229131e-08 4.02645553947883e-07 2820 2004.45454545455 2166 4.25383706371939e-09 199 3.02078080729967 -2.36717017686361 -1 23.2603326086259 2816 1217 4600 858 199 2166 2302 3932 392 1335 2232 2116 M15033 GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. 28/54 Gene Ontology BP GO:0045581 5.52420503650726e-07 9.52004667958085e-07 1575 2241.36363636364 2168 5.0220058396699e-08 1370 2.15364237766577 -2.58099514662168 -1 15.5803352620542 1574 2059 2168 3938 2657 2339 2592 1370 2770 1718 1470 2117 M13392 GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. 12/14 Gene Ontology BP GO:2000052 7.68204309351841e-06 9.20776571719247e-06 2875 2186.90909090909 2169 6.98369992554343e-07 541 2.67126509157775 3.2048417671147 1 16.165950703919 2875 2258 1887 1395 3857 2334 2003 2653 541 2084 2169 2118 M13529 GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN.html The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. 14/25 Gene Ontology BP GO:0032490 1.34955406363776e-06 1.91151028601039e-06 65 1670.09090909091 2169 1.22686808318215e-07 62 2.3736133296499 -2.3736133296499 -1 16.313160611331 62 3360 2169 3223 3254 76 127 612 2665 2490 333 2119 M14644 GO_PEPTIDYL_TYROSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_MODIFICATION.html The modification of peptidyl-tyrosine. 167/243 Gene Ontology BP GO:0018212 1.19345637399637e-07 4.10546590935448e-07 4305 2659.45454545455 2169 1.08496039885365e-08 685 2.25382240509058 2.38072029946501 1 17.3055269644448 4302 1740 685 1014 1233 4326 3852 4338 2169 1136 4459 2120 M16125 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST.html Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. 134/211 Gene Ontology BP GO:0050691 5.83697349751165e-07 9.94122902046915e-07 2255 1729.09090909091 2169 5.30634095105491e-08 367 2.58809688904258 -2.39222848066441 -1 18.6852798408189 2252 2394 758 2169 2690 2333 2365 906 1235 1551 367 2121 M16119 GO_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. 126/185 Gene Ontology BP GO:0006766 1.96584390707043e-07 4.93246485651519e-07 4535 2411.63636363636 2170 1.78713098430133e-08 15 2.16718037027767 2.07959864638899 1 16.4274090651115 4533 15 1112 2170 1775 4053 4350 2456 1083 968 4013 2122 M13693 GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that activates or increases the frequency, rate or extent of receptor internalization. 20/32 Gene Ontology BP GO:0002092 2.96796028292429e-07 6.19278887733037e-07 3965 2528.90909090909 2171 2.69814607574894e-08 545 2.36950413242289 2.04846199582322 1 17.6874598749898 3964 2133 1431 545 2171 3388 4176 1288 3334 1498 3890 2123 M10801 GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. 31/45 Gene Ontology BP GO:0040020 5.77700669667511e-07 9.87524326217094e-07 1920 1937.63636363636 2173 5.25182564878806e-08 550 1.9565236913249 1.78607859341567 1 14.1072305809419 1916 760 2173 2278 2680 932 550 2924 1766 2748 2587 2124 M13122 GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 27/35 Gene Ontology BP GO:0040036 6.3453449808121e-08 4.02645553947883e-07 2045 2161.45454545455 2174 5.76849560347963e-09 451 2.01106908741952 2.11343896239637 1 15.4510310920033 2045 2575 2174 1022 451 1589 1545 4271 3306 2242 2556 2125 M14969 GO_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of MAP kinase activity. 371/484 Gene Ontology BP GO:0043405 9.73219779405004e-08 4.02645553947883e-07 2955 2054.18181818182 2174 8.8474529314326e-09 885 1.95802147767201 -1.73882832376226 -1 15.0407508396322 2955 1524 885 1203 975 2844 2174 3664 2439 970 2963 2126 M14817 GO_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 238/332 Gene Ontology BP GO:0051260 7.24971568327048e-08 4.02645553947883e-07 4625 2440.18181818182 2175 6.59065083833836e-09 608 2.16361976154703 2.14589742997466 1 16.6308868739756 4625 1618 1077 1049 608 3810 4016 2920 2175 1318 3626 2127 M10229 GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. 168/229 Gene Ontology BP GO:0043524 2.99761159953631e-07 6.23973595231859e-07 4155 2527.90909090909 2176 2.72510182543288e-08 1219 1.94683212879864 2.24329351594021 1 14.5062836558138 4151 1743 1636 1219 2176 4481 3188 2203 1563 1645 3802 2128 M11158 GO_L_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSPORT.html The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 42/67 Gene Ontology BP GO:0015807 1.75262635072029e-07 4.65466347597117e-07 3530 2584.72727272727 2178 1.59329680940272e-08 530 2.09205797351602 1.97286662869677 1 15.9181039075899 3529 530 1498 2178 1672 3787 4607 3557 964 1708 4402 2129 M10563 GO_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that modulates the frequency, rate or extent of cellular senescence. 40/46 Gene Ontology BP GO:2000772 2.68049248816752e-07 5.77706783125219e-07 2765 2440 2179 2.43681164978209e-08 1537 1.77449292423674 2.24533816151216 1 13.2848361048929 2762 3701 2865 2610 2098 2179 2038 1812 1690 3548 1537 2130 M10923 GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. 33/56 Gene Ontology BP GO:0045762 8.40042606296251e-08 4.02645553947883e-07 2180 2187.63636363636 2179 7.63675125792938e-09 790 2.1074168199839 2.14671427428279 1 16.1962026882362 2179 2024 1978 2475 790 1781 2608 2751 3051 1765 2662 2131 M13469 GO_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 45/70 Gene Ontology BP GO:0048708 1.12719281987595e-07 4.05064193023647e-07 3020 2163.81818181818 2179 1.0247207978444e-08 271 2.074050272859 -2.19580587358515 -1 15.9316154132097 3017 2500 1863 271 1176 2670 1550 3941 2179 1775 2860 2132 M12134 GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 14/26 Gene Ontology BP GO:0071257 0.000429762080619113 0.000447156297209466 1870 2191.72727272727 2181 3.90769141874052e-05 431 2.05998404841138 -2.35497482216767 -1 8.24188423084175 1870 3047 2099 1146 4449 2544 591 2784 431 2967 2181 2133 M12042 GO_NEGATIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COAGULATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. 48/67 Gene Ontology BP GO:0050819 2.2023281139199e-08 3.22246311763185e-07 2165 2081.54545454545 2182 2.00211648724226e-09 180 2.9135253864395 3.34353032641066 1 22.7716551194237 2163 484 216 2650 2182 2451 4638 1641 3658 180 2634 2134 M15963 GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. 14/24 Gene Ontology BP GO:0036152 1.18534921498901e-06 1.70915088235013e-06 575 1831.36363636364 2182 1.07759077604531e-07 92 2.43576916504851 -2.21503115367968 -1 16.8861912431597 571 3355 2182 2436 3497 375 381 92 3612 2971 673 2135 M10042 GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL.html A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. 39/78 Gene Ontology BP GO:0097553 4.11788294990924e-08 4.02645553947883e-07 3155 1981.27272727273 2183 3.74353002453303e-09 93 2.27563353434682 2.78995866203529 1 17.4972225899875 3153 502 814 93 144 4110 3455 3681 2183 985 2674 2136 M10521 GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 30/37 Gene Ontology BP GO:0006221 3.03662863564681e-07 6.30778260788599e-07 1275 2442.72727272727 2183 2.76057186798947e-08 1274 1.16907355051071 1.19055147465662 1 8.66323806362251 1274 2017 3494 2926 2183 1863 2153 2375 2143 3728 2714 2137 M16606 GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL.html The directed movement of calcium ion into a cytosol. 39/78 Gene Ontology BP GO:1902656 4.11788294990924e-08 4.02645553947883e-07 3155 1981.81818181818 2184 3.74353002453303e-09 94 2.27563353434682 2.78995866203529 1 17.4972225899875 3154 503 815 94 145 4111 3456 3675 2184 988 2675 2138 M12619 GO_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYMERIZATION.html The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. 74/96 Gene Ontology BP GO:0051258 5.07638325205769e-07 8.9335897397218e-07 2410 2472.63636363636 2185 4.6148949303696e-08 1775 2.01025123597173 -1.8684050138195 -1 14.6032624213676 2409 1864 1775 2432 2597 3505 4175 2185 2047 2174 2036 2139 M15771 GO_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_CHECKPOINT.html A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. 230/269 Gene Ontology BP GO:0000075 3.04196819746768e-07 6.31323729831273e-07 2185 2093.09090909091 2185 2.76542601644056e-08 527 1.70968425682596 1.84934270284366 1 12.7161840031842 1415 2786 3265 2920 2185 527 1095 2184 1831 2549 2267 2140 M15883 GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 17/22 Gene Ontology BP GO:0043649 2.20251019548764e-06 2.9347880697606e-06 480 1945.90909090909 2185 2.00228400046726e-07 375 1.58518033381446 -1.66902138937653 -1 10.5033220936389 476 2185 2465 2889 3460 477 375 1553 3866 2598 1061 2141 M12181 GO_ESTABLISHMENT_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization or cell growth patterns. 124/172 Gene Ontology BP GO:0030010 1.32968264020204e-07 4.20399283289481e-07 2540 2250.90909090909 2186 1.20880247324384e-08 1251 1.84305176271294 2.18469290697151 1 14.1097842841387 2540 1818 2186 2023 1366 2400 4404 2232 1251 2363 2177 2142 M16762 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of macrophage differentiation. 13/17 Gene Ontology BP GO:0045651 3.04538240065943e-07 6.31750526538936e-07 2260 1889.54545454545 2186 2.76852983838278e-08 590 2.31031063758302 -2.75523451957238 -1 17.218835688713 2257 2704 1527 2440 2186 2360 1884 729 3099 1009 590 2143 M12325 GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. 14/31 Gene Ontology BP GO:0021895 1.05846892756658e-07 4.02645553947883e-07 3610 2039.18181818182 2187 9.62244525901713e-09 267 2.04993388774144 -0.980086119510119 -1 15.7516188123609 3608 1142 2187 2294 1088 3126 1004 556 267 3359 3800 2144 M13375 GO_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that modulates the frequency, rate, or extent of cellular extravasation. 21/37 Gene Ontology BP GO:0002691 2.83444913458291e-07 5.99980766863418e-07 2310 2340.09090909091 2187 2.57677227251766e-08 402 2.44619060137775 2.22776200984173 1 18.303902836908 2308 2617 1552 3182 2140 2187 3282 402 3875 2068 2128 2145 M15414 GO_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_INVAGINATION.html The infolding of a membrane, resulting in formation of a vesicle. 41/170 Gene Ontology BP GO:0010324 5.99003128478359e-08 4.02645553947883e-07 2045 2176.81818181818 2187 5.44548313443334e-09 403 2.50283300792933 -2.07555035363064 -1 19.2544263132783 2042 2885 1830 2480 403 2145 2187 2435 3009 2704 1825 2146 M12352 GO_CENTRIOLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE_ASSEMBLY.html A cellular process that results in the assembly of one or more centrioles. 20/27 Gene Ontology BP GO:0098534 3.05336470133126e-07 6.32560372007763e-07 905 2196.09090909091 2189 2.77578647736883e-08 729 1.38154810529048 1.27823386186652 1 10.254412725654 903 3542 3457 2975 2189 1053 729 1868 1319 3671 2451 2147 M16275 GO_REGULATION_OF_CELL_PROJECTION_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_SIZE.html A process that modulates the size of a cell projection. 17/27 Gene Ontology BP GO:0032536 7.20596091251652e-07 1.15379683847004e-06 4570 2032.09090909091 2189 6.55087570253141e-08 116 3.13864865780325 2.73153755768507 1 22.4364471435719 4568 991 924 116 2862 3373 3498 1010 227 2189 2595 2148 M15437 GO_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. 120/149 Gene Ontology BP GO:0050673 3.05862003984523e-07 6.33367113724961e-07 3530 2007 2190 2.78056405916337e-08 20 2.46346803601908 2.65839626274396 1 18.3638424297422 3528 20 367 525 2190 2676 4131 3180 2146 528 2786 2149 M11240 GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION.html The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. 13/14 Gene Ontology BP GO:0036508 3.45951584952984e-06 4.42471886967079e-06 1520 2415.09090909091 2191 3.14501935423219e-07 1030 1.0415879041522 -1.05756986221032 -1 6.64158596924619 1518 1156 3391 3205 3611 2027 2191 2999 1030 3894 1544 2150 M16270 GO_DEFENSE_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_FUNGUS.html Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. 20/101 Gene Ontology BP GO:0050832 2.58074471563522e-07 5.67674433889539e-07 4405 2574.45454545455 2191 2.34613183488509e-08 727 3.4533558753353 2.05366661876486 1 25.9829177648017 4401 2145 727 2191 2055 4396 3549 3605 1017 1500 2733 2151 M10601 GO_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 137/177 Gene Ontology BP GO:0010921 1.24156194929804e-07 4.14338946095474e-07 2585 2245.63636363636 2192 1.1286927448774e-08 1281 1.7234623559401 -1.50431610443732 -1 13.200711785929 2582 2818 3023 1821 1281 1808 1394 2906 1912 2965 2192 2152 M12900 GO_PROTEIN_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMANNOSYLATION.html The removal of one or more mannose residues from a mannosylated protein. 13/14 Gene Ontology BP GO:0036507 3.45951584952984e-06 4.42471886967079e-06 1520 2415.63636363636 2192 3.14501935423219e-07 1031 1.0415879041522 -1.05756986221032 -1 6.64158596924619 1519 1157 3392 3206 3612 2028 2192 2992 1031 3898 1545 2153 M14868 GO_MAST_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a mast cell. 21/51 Gene Ontology BP GO:0002448 3.08309278970394e-07 6.37300344313301e-07 4015 2454.90909090909 2193 2.80281201979131e-08 372 2.23706176496733 2.18482399130707 1 16.6593677350486 4014 913 1427 1138 2193 3909 3911 3306 372 2069 3752 2154 M13320 GO_RENAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_WATER_HOMEOSTASIS.html Renal process involved in the maintenance of an internal steady state of water in the body. 31/53 Gene Ontology BP GO:0003091 2.05507931265069e-07 5.00119458251237e-07 2785 2170.63636363636 2195 1.86825409511019e-08 749 2.04064104994391 2.02593180475597 1 15.447387060125 2781 749 1924 2195 1835 2545 2972 3337 1421 2753 1365 2155 M14486 GO_RESPONSE_TO_MUSCLE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. 36/61 Gene Ontology BP GO:0014850 2.66404050598174e-07 5.75701307057915e-07 2160 2531.81818181818 2197 2.42185529870708e-08 1592 2.30980705816975 2.15768578936228 1 17.3277722689296 2159 3232 1998 2997 2093 2197 1592 4304 2345 2136 2797 2156 M13309 GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 production. 54/103 Gene Ontology BP GO:0032652 1.19718634300584e-06 1.72301517290634e-06 2095 2458.09090909091 2198 1.08835181316904e-07 1292 2.02556240987732 -2.3851175844276 -1 14.0164612412787 2092 2870 1349 2787 3193 1948 1960 2198 4201 1292 3149 2157 M12756 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. 10/28 Gene Ontology BP GO:0032693 0.000495084466667632 0.000513973231460172 2200 2158.90909090909 2199 4.50178104358733e-05 615 3.21735335105975 -2.84806462978914 -1 12.6949654217477 2199 3083 1602 2410 4535 1770 801 1057 615 2691 2985 2158 M15407 GO_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 794/1446 Gene Ontology BP GO:0009607 1.50598168056177e-07 4.37329540718478e-07 1620 2255.54545454545 2199 1.50598178262091e-08 249 2.14756638714131 -2.14286989983149 -1 16.4135219711493 1619 2324 4554 2829 1616 2199 2210 2047 3162 249 2002 2159 M16594 GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process that decreases the concentration of calcium ions in the cytosol. 8/20 Gene Ontology BP GO:0051481 3.90084758474155e-06 4.93358081321078e-06 1425 2311.09090909091 2201 3.90085443223382e-07 150 2.5267167438696 2.52595182686129 1 16.1137009636833 1424 2302 4639 3724 3676 1102 150 1442 4228 2201 534 2160 M15396 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. 27/46 Gene Ontology BP GO:0032736 4.21406646299713e-06 5.30233944086686e-06 175 2143.72727272727 2202 3.83097684999895e-07 172 1.26281802506824 -1.26834982399484 -1 7.95409264483339 172 791 3007 2568 3674 1252 1783 1632 3942 2558 2202 2161 M13657 GO_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE.html The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. 396/732 Gene Ontology BP GO:0006954 7.84015172366976e-27 3.31638417911231e-24 2330 1699.81818181818 2203 7.12741065788161e-28 3 2.58061125182452 -2.55140138508641 -1 73.1756807106582 2327 1498 3 301 925 2977 2245 3246 2203 47 2926 2162 M12728 GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. 34/51 Gene Ontology BP GO:1901224 3.91327707849856e-07 7.48396146578454e-07 835 2069.63636363636 2204 3.5575252496161e-08 660 1.92589444361981 -1.89119929434959 -1 14.1652411663888 835 3504 2970 1676 2384 837 660 2482 3331 2204 1883 2163 M11979 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. 36/79 Gene Ontology BP GO:2000107 9.43716134077235e-08 4.02645553947883e-07 4405 2551.45454545455 2205 8.5792379505369e-09 936 2.29824335564671 2.25327313084417 1 17.6720912265413 4403 1986 1434 2669 936 3481 2205 4541 1211 1306 3894 2164 M11003 GO_POLYOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 87/118 Gene Ontology BP GO:0019751 1.19685257283274e-06 1.72301517290634e-06 1590 2374.63636363636 2206 1.08804838540876e-07 565 1.83684174907446 -1.94628331863584 -1 12.7009618626894 1588 2837 2793 3877 3192 2206 2162 565 1846 3707 1348 2165 M12246 GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an external stimulus. 941/1381 Gene Ontology BP GO:0032101 4.48987560642874e-09 8.06617420722507e-08 2145 1958.81818181818 2207 4.48987561550028e-10 37 2.09099316395798 -1.97927110383833 -1 17.834956083742 2144 1354 4357 37 537 2214 2207 3440 2749 147 2361 2166 M12334 GO_FATTY_ACID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. 17/37 Gene Ontology BP GO:0055089 5.05115507133846e-05 5.5340297967831e-05 2355 2226.81818181818 2207 4.59206458959572e-06 825 1.71799799791348 -1.56627238245083 -1 8.7419045863402 2352 2199 2924 825 4220 2207 2941 1337 997 3008 1485 2167 M12462 GO_PROTEIN_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DESTABILIZATION.html Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. 42/51 Gene Ontology BP GO:0031648 3.43420057414596e-07 6.85514168661567e-07 985 1969.36363636364 2207 3.12200100929534e-08 108 1.60238715995234 -1.66861894293716 -1 11.8423663175472 982 3494 3437 3006 2275 1125 757 426 2207 3846 108 2168 M15900 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein. 15/20 Gene Ontology BP GO:0042510 6.91375257851564e-08 4.02645553947883e-07 3910 2281.72727272727 2207 6.28522981435298e-09 243 2.28379630899788 1.64292803306848 1 17.5603550338398 3906 2207 2041 1176 556 3954 3099 1592 243 2237 4088 2169 M14197 GO_CELLULAR_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 28/32 Gene Ontology BP GO:0036315 1.24666779396876e-07 4.14338946095474e-07 2350 2142.54545454545 2209 1.13333442237576e-08 1231 2.65117362682908 2.67088662892637 1 20.3618570095811 2346 2571 1323 2268 1289 2209 2708 4210 2002 1411 1231 2170 M15075 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 110/162 Gene Ontology BP GO:0050806 3.14773514579874e-07 6.45277415956415e-07 4505 2579.45454545455 2209 2.86157781470293e-08 82 2.32552365958734 -1.70555605436402 -1 17.307019663603 4501 82 644 1769 2209 4122 3912 4263 2118 638 4116 2171 M12339 GO_REGULATION_OF_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_AGGREGATION.html Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. 21/26 Gene Ontology BP GO:0090330 5.37134302606529e-07 9.33265836455631e-07 2215 1786.27272727273 2211 4.88304030680877e-08 485 2.67154086319977 3.36824123758074 1 19.3796800036026 2211 911 659 962 2630 2480 3940 2328 797 485 2246 2172 M13369 GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 13/20 Gene Ontology BP GO:0050857 3.69455953332822e-07 7.16282729524009e-07 2980 2165 2212 3.35869104888407e-08 1300 2.56453504832362 -2.83941536204158 -1 18.9557549800412 2978 2212 1387 1300 2345 2908 2146 1324 2995 1381 2839 2173 M11753 GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. 26/36 Gene Ontology BP GO:0060122 5.02999623650937e-08 4.02645553947883e-07 3445 2461.27272727273 2213 4.57272395592118e-09 251 2.28551001583516 2.4985644542055 1 17.5736091668165 3442 2580 1738 2213 251 4448 2741 4611 1034 2103 1913 2174 M14671 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition. 119/135 Gene Ontology BP GO:1902807 1.90076712383188e-07 4.86483466842119e-07 1880 2307.18181818182 2214 1.72797026186849e-08 1346 1.91080507802058 1.99094923660403 1 14.4857391241069 1877 3161 2942 2958 1737 1346 1647 2894 1558 3045 2214 2175 M11065 GO_PRIMITIVE_STREAK_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMITIVE_STREAK_FORMATION.html The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. 10/19 Gene Ontology BP GO:0090009 5.10217757530038e-07 8.96203558243589e-07 2225 2214.09090909091 2215 4.63834432598483e-08 664 2.79539103196724 3.06082701868246 1 20.3423737277553 2224 3386 2007 664 2603 2215 2459 3168 1826 2142 1661 2176 M16172 GO_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_IMPORT.html The directed movement of amino acids into a cell or organelle. 13/29 Gene Ontology BP GO:0043090 3.1584112608888e-07 6.45981872391893e-07 3930 2055.36363636364 2216 2.87128337665774e-08 569 2.26071389826409 -2.6788786595826 -1 16.820527333657 3927 1128 1500 2386 2216 3391 1198 997 569 2301 2996 2177 M14676 GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. 11/23 Gene Ontology BP GO:1902259 1.04929252378933e-06 1.5489714826116e-06 1320 1944.09090909091 2217 9.53902749319034e-08 136 2.33820798529715 -2.72341882740405 -1 16.3265682662923 1319 2726 2217 2486 3115 882 136 2162 1509 2383 2450 2178 M13704 GO_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_LOCALIZATION.html Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. 27/39 Gene Ontology BP GO:0051647 2.10590027893796e-07 5.07444536400742e-07 3055 2312.63636363636 2218 1.91445498229139e-08 282 2.06844701894794 -1.53049644777047 -1 15.6434805243394 3051 819 2055 1982 1858 3041 2218 3465 282 3202 3466 2179 M10692 GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER.html The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 15/16 Gene Ontology BP GO:0090557 6.28328368324391e-06 7.64342979820495e-06 1525 2431.54545454545 2221 5.71209238964806e-07 956 1.85508627946903 -1.54339327832252 -1 11.3765712703394 1525 3573 2672 1963 3797 2221 956 2181 2264 3464 2131 2180 M16552 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 14/18 Gene Ontology BP GO:0010661 2.33340304574791e-07 5.37133724763818e-07 4615 2761.18181818182 2221 2.12127572112499e-08 1623 1.98212784199262 1.45865535977562 1 14.9271641234093 4612 2221 2108 1623 1957 3315 2104 2835 3101 2050 4447 2181 M13739 GO_MAMMARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. 155/219 Gene Ontology BP GO:0030879 1.16959610062134e-07 4.08625383150012e-07 3890 2248.81818181818 2222 1.06326923891011e-08 259 2.23959482982233 -2.25100393227303 -1 17.2011510555209 3890 1766 609 259 1215 4428 3845 2240 2222 1051 3212 2182 M15495 GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. 32/33 Gene Ontology BP GO:0033627 0.000431217615759194 0.00044857043731892 185 2320.90909090909 2223 3.92092873696184e-05 183 2.71778777960187 2.89795807685117 1 10.9020908810118 183 2920 855 1874 4450 2051 2912 2979 3941 1142 2223 2183 M16750 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. 28/47 Gene Ontology BP GO:0002483 5.01853500842089e-06 6.23864370670115e-06 195 2082.09090909091 2223 4.56231496045455e-07 195 1.36646851080131 -1.0865661145208 -1 8.4986937817906 195 737 2751 2441 3719 1169 1574 2223 3423 2719 1952 2184 M15637 GO_PEPTIDE_HORMONE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_PROCESSING.html The generation of a mature peptide hormone by posttranslational processing of a prohormone. 18/44 Gene Ontology BP GO:0016486 1.22402577919045e-07 4.14338946095474e-07 1760 1879.54545454545 2225 1.11275077026567e-08 490 1.64929789723343 -1.63172303185265 -1 12.6282249833022 1758 981 2225 3380 1258 1026 490 2310 2662 2341 2244 2185 M16535 GO_CORTICAL_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. 57/61 Gene Ontology BP GO:0030865 2.04140347657979e-07 4.99665985088152e-07 4055 2520.81818181818 2225 1.85582151454893e-08 386 2.17039422949132 -2.04550105943231 -1 16.4371823678375 4051 386 1725 1092 1826 3869 2634 4099 1481 2225 4341 2186 M16775 GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 16/17 Gene Ontology BP GO:0010839 7.71682610259399e-06 9.23993614394488e-06 1335 2056.72727272727 2225 7.01532106421665e-07 520 1.91243117523369 2.5200860537974 1 11.5408919695902 1334 1087 2229 2225 3861 2502 3599 520 859 3241 1167 2187 M10406 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 15/20 Gene Ontology BP GO:0038084 5.90427954087576e-05 6.42333708293077e-05 1860 2420.63636363636 2226 5.36767091247695e-06 710 1.69991488487816 1.82831078707406 1 8.51575184552452 1858 2694 2716 2587 4247 1348 710 2082 4171 2226 1988 2188 M12539 GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. 125/222 Gene Ontology BP GO:0071346 1.30280565314196e-06 1.85324203731873e-06 295 2178.81818181818 2226 1.18436947694888e-07 293 1.90159304722603 -1.84721912761149 -1 13.0795462565118 293 3154 1778 3467 3238 1321 1291 2226 3922 1004 2273 2189 M15470 GO_CELLULAR_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 294/401 Gene Ontology BP GO:1901653 4.86731609724573e-08 4.02645553947883e-07 2225 2070.18181818182 2226 4.42483291357367e-09 228 1.76617288476936 -1.69109576910629 -1 13.5569575172229 2223 2350 2509 2226 228 2084 1830 1537 2295 2852 2638 2190 M11297 GO_CARBOHYDRATE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHORYLATION.html The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. 21/24 Gene Ontology BP GO:0046835 2.22813856156868e-08 3.23985272718095e-07 2230 2349.09090909091 2227 2.02558053103186e-09 19 1.2944256918354 -1.5427954119372 -1 10.0561525977667 2227 3293 3409 4323 19 1616 1252 936 3714 3941 1110 2191 M11992 GO_REGULATION_OF_CENTRIOLE_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTRIOLE_REPLICATION.html Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. 14/18 Gene Ontology BP GO:0046599 1.30705799736077e-05 1.51626548534522e-05 1405 2459.54545454545 2227 1.18824160262061e-06 364 0.898291404744827 1.03924245876952 1 5.13260574034841 1404 2227 3582 3926 3984 1029 364 1197 4185 3976 1181 2192 M11243 GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of vacuolar transport. 21/23 Gene Ontology BP GO:1903337 3.22407638406231e-07 6.56526363896802e-07 1320 2168.54545454545 2228 2.93097896049758e-08 348 1.25865265323427 -1.03149385679814 -1 9.30849002875405 1320 2117 3426 2313 2228 1178 348 2183 2738 3441 2562 2193 M16636 GO_ESTROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 18/50 Gene Ontology BP GO:0008210 2.68471985955168e-07 5.78333403078425e-07 2220 2571.81818181818 2228 2.440654715614e-08 697 1.83797007003778 2.20160799132525 1 13.7626976212504 2218 3316 2775 4486 2100 2050 2228 697 2867 3459 2094 2194 M12954 GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. 14/31 Gene Ontology BP GO:0045652 3.92540248256075e-07 7.49790548085187e-07 4330 2468.27272727273 2229 3.56854834814565e-08 655 2.69637698777404 1.94719071306953 1 19.8708088542352 4327 2229 1674 2078 2387 3461 3009 655 1923 2039 3369 2195 M14107 GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 23/45 Gene Ontology BP GO:0050996 3.24340068174301e-07 6.60172500968951e-07 3110 2270.36363636364 2229 2.94854650900812e-08 920 2.27956780810009 -2.18589133155648 -1 16.9356487059702 3108 920 1733 1152 2229 3725 3595 2480 2504 1660 1868 2196 M14627 GO_CERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. 65/80 Gene Ontology BP GO:0006672 1.25851206740488e-06 1.79958716952517e-06 2245 2216.63636363636 2229 1.14410253394406e-07 337 1.87238828951329 -1.81880350391554 -1 12.9059815635348 2242 337 2702 4097 3215 2745 2229 1493 1803 1826 1694 2197 M15760 GO_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 646/808 Gene Ontology BP GO:0010564 2.38335174022516e-07 5.44147970915979e-07 1220 2440.81818181818 2230 2.38335199584164e-08 1059 1.58867675217226 1.70577547304583 1 11.932868702435 1217 3112 4570 3096 2074 1059 1304 2230 2780 3667 1740 2198 M13401 GO_EXOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCRINE_SYSTEM_DEVELOPMENT.html Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. 61/75 Gene Ontology BP GO:0035272 4.50809360929063e-07 8.26483828369948e-07 2235 1936.09090909091 2231 4.09826775732676e-08 307 2.29151332379995 2.56396694327123 1 16.7545155048732 2231 307 949 607 2488 2445 4264 2974 1164 1133 2735 2199 M13475 GO_RESPONSE_TO_ESTROGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTROGEN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 256/351 Gene Ontology BP GO:0043627 9.48134815023161e-09 1.58693212025279e-07 3050 2040.63636363636 2231 8.61940744644858e-10 165 2.33114991174754 2.3113221955623 1 19.0666162991565 3046 1599 197 165 769 2231 4148 4107 2272 289 3624 2200 M10779 GO_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. 12/21 Gene Ontology BP GO:0043501 2.39262515423716e-06 3.15694399601259e-06 3495 2518.63636363636 2235 2.17511614214281e-07 1002 3.15607951295064 -0.957038124778578 -1 20.893088453467 4385 3589 1652 2235 3492 3750 1309 1002 1218 3493 1580 2201 M13725 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 36/61 Gene Ontology BP GO:0071380 3.26318978809534e-07 6.62750854823554e-07 3875 2694.63636363636 2235 2.9665366110127e-08 1307 2.36630583838094 2.69384190610029 1 17.5791265833366 3871 1979 1307 1830 2235 4620 2875 4071 1359 1835 3659 2202 M15772 GO_NEPHRON_TUBULE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_TUBULE_FORMATION.html The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. 14/25 Gene Ontology BP GO:0072079 2.11312775739958e-06 2.83109227042334e-06 3005 2496.72727272727 2235 1.92102707917108e-07 1130 1.99578847468974 -1.2556490445781 -1 13.2883678552629 3004 1130 1730 2082 3443 2235 1568 4583 3336 1571 2782 2203 M11145 GO_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_MORPHOGENESIS.html The process in which the anatomical structures of the lung are generated and organized. 50/70 Gene Ontology BP GO:0060425 3.99030186074174e-07 7.56705814693271e-07 2735 1813.72727272727 2236 3.62754780408393e-08 214 2.35213919826777 2.74551457238785 1 17.3094802042756 2732 418 1109 561 2405 2236 2938 2688 214 1341 3309 2204 M13970 GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of T cell cytokine production. 34/76 Gene Ontology BP GO:0002724 1.01550538486356e-05 1.19684563216063e-05 145 2203.36363636364 2236 9.23190974908407e-07 144 1.28279040955778 -1.2526735750478 -1 7.53299013166545 144 2532 3159 2574 3922 604 1446 2236 4238 1924 1458 2205 M16662 GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. 8/12 Gene Ontology BP GO:0042487 1.34301140480105e-07 4.22231896387789e-07 2205 2308.45454545455 2236 1.34301148596664e-08 397 5.37926779069321 5.62654188071873 1 41.3671174011959 2422 2297 4642 2205 1477 2433 3371 1711 397 2202 2236 2206 M11963 GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 18/20 Gene Ontology BP GO:0051974 5.55023735582871e-07 9.55429316192045e-07 1455 2284.81818181818 2238 5.04567159642054e-08 173 2.45874139935731 2.76004468304775 1 17.7974955399073 1454 4522 2572 4196 2661 1410 747 1167 173 3993 2238 2207 M10653 GO_CELLULAR_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 520/821 Gene Ontology BP GO:0071396 1.01221513838467e-07 4.02645553947883e-07 2940 2355.90909090909 2239 1.01221518449075e-08 225 2.31532301398094 2.35620692902007 1 17.8041885362058 2939 1449 4253 544 1167 2239 4122 4015 2094 225 2868 2208 M16717 GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of anion transport. 64/109 Gene Ontology BP GO:1903793 3.29033285258807e-07 6.66639210726007e-07 4550 2348.90909090909 2239 2.99121213153842e-08 318 2.65838889824879 -2.25152618484614 -1 19.7535324444837 4550 318 554 1715 2239 3814 2548 2656 2141 1336 3967 2209 M11705 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 165/207 Gene Ontology BP GO:1903828 1.33097191733352e-07 4.20399283289481e-07 1755 2585.90909090909 2240 1.20997454350511e-08 1368 1.61249015928449 -1.47190453896824 -1 12.3318024226606 1755 3142 3536 4481 1368 2116 1461 3034 2240 3650 1662 2210 M13958 GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 12/18 Gene Ontology BP GO:0001574 1.13993512296336e-06 1.65650160123314e-06 2310 2332 2240 1.03630519420347e-07 852 2.51328349301823 2.93342599143325 1 17.4681460039897 2310 2240 1368 2186 3170 2191 2621 4353 2552 852 1809 2211 M15041 GO_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXPLORATION_BEHAVIOR.html The specific behavior of an organism in response to a novel environment or stimulus. 30/41 Gene Ontology BP GO:0035640 6.61797756586011e-07 1.08733932252638e-06 2625 2314.09090909091 2240 6.01634505151108e-08 1157 2.84832142239593 3.18889516526525 1 20.4402876019869 2625 3242 1198 2240 2787 2436 1849 3980 2060 1157 1881 2212 M16351 GO_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_KILLING.html Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. 66/138 Gene Ontology BP GO:0031341 3.29212701690999e-07 6.66639210726007e-07 2235 2181.27272727273 2241 2.99284319050093e-08 286 1.8126870342824 -1.42526608465319 -1 13.4366723259183 2232 286 1506 2451 2241 1814 2570 3214 4005 1164 2511 2213 M12343 GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. 58/66 Gene Ontology BP GO:1900024 1.7591926454245e-07 4.66677501662496e-07 4080 2481.63636363636 2242 1.5992661691776e-08 385 2.10093884702771 -2.09166429851122 -1 15.9832464179355 4078 385 1835 2242 1674 3005 3707 3567 1777 1881 3147 2214 M16327 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. 29/37 Gene Ontology BP GO:0000083 1.62357731066103e-05 1.86163263344154e-05 955 2201.36363636364 2242 1.4759902660163e-06 795 1.80800074873066 1.93633255957259 1 10.2398508644888 953 2552 2411 1962 4030 1742 1748 2242 795 2850 2930 2215 M10366 GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. 11/17 Gene Ontology BP GO:0031953 1.40353358108233e-06 1.97598842746628e-06 4425 2648.27272727273 2243 1.27594043317743e-07 1074 2.41932762251397 -1.92347068143054 -1 16.5871686121041 4424 2243 1446 1126 3275 3848 3684 2208 1074 1352 4451 2216 M15754 GO_RESPONSE_TO_MERCURY_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MERCURY_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. 13/20 Gene Ontology BP GO:0046689 2.75522724599916e-07 5.8888710958356e-07 3425 2378.18181818182 2244 2.50475235550661e-08 238 2.2782098138081 -2.39382951027327 -1 17.062229266218 3421 2244 2197 2680 2118 3352 1671 2013 238 3217 3009 2217 M16659 GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 38/47 Gene Ontology BP GO:0072528 9.87662467217377e-07 1.47815807653987e-06 1025 2122.09090909091 2244 8.97875373287601e-08 590 1.30895186353977 1.34988513690218 1 9.12662419249336 1023 590 3207 2420 3071 1830 2244 1923 1322 2943 2770 2218 M11723 GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS.html Any process that modulates levels of neurotransmitter. 184/285 Gene Ontology BP GO:0001505 2.36132270999668e-07 5.40178690738178e-07 3355 2155.36363636364 2247 2.14665723949474e-08 508 1.99887222577138 -1.9030702199999 -1 15.0481989419559 3354 1693 715 700 1971 2253 2460 3840 2247 508 3968 2219 M15938 GO_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORT.html The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 55/104 Gene Ontology BP GO:0015908 1.48656859888317e-07 4.36901586057683e-07 3170 2122.36363636364 2247 1.35142609030232e-08 394 2.20657279661053 -1.85437046187029 -1 16.8684624904063 3167 394 1082 1131 1485 3606 2247 2568 3587 890 3189 2220 M16160 GO_PROTEIN_INSERTION_INTO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_INSERTION_INTO_MEMBRANE.html The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. 22/30 Gene Ontology BP GO:0051205 1.26295930517908e-07 4.16747130248656e-07 2130 2552.45454545455 2249 1.14814488880191e-08 654 2.05936785041115 -2.33916413356485 -1 15.7873492068236 3551 2128 2130 2743 1302 4410 4454 1870 654 2586 2249 2221 M16572 GO_LYSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. 13/16 Gene Ontology BP GO:0006553 3.97543911325279e-07 7.54393074794667e-07 2215 2348.90909090909 2249 3.61403621056535e-08 693 1.56754574731046 1.13164374116327 1 11.5038047010109 2212 2249 3089 3706 2403 1583 808 4256 693 3219 1620 2222 M10834 GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that activates or increases the frequency, rate or extent of membrane invagination. 20/22 Gene Ontology BP GO:1905155 1.26855643112564e-07 4.16747130248656e-07 3405 2537.09090909091 2250 1.15323318570247e-08 1307 2.95434818488852 -2.10918473957188 -1 22.693115107964 3405 3546 1731 2250 1307 3430 2124 1674 1385 2643 4413 2223 M14759 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 20/22 Gene Ontology BP GO:0060100 1.26855643112564e-07 4.16747130248656e-07 3410 2541.36363636364 2251 1.15323318570247e-08 1308 2.95434818488852 -2.10918473957188 -1 22.693115107964 3406 3547 1732 2251 1308 3431 2125 1705 1386 2650 4414 2224 M15184 GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. 47/59 Gene Ontology BP GO:0030834 1.03416642526514e-07 4.02645553947883e-07 3225 2554.45454545455 2251 9.4015133988981e-09 1054 2.04858630545559 1.97077103353292 1 15.7411963559495 3221 1921 2251 1943 1054 3173 4589 2027 1320 2256 4344 2225 M12269 GO_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION.html The movement of a leukocyte within or between different tissues and organs of the body. 241/380 Gene Ontology BP GO:0050900 5.21583852682562e-17 3.51728937178545e-15 3260 2012.54545454545 2253 4.74167138802328e-18 36 2.52106652794961 -2.63484095731525 -1 43.9662368282632 3256 1603 36 848 1941 3136 2253 2459 3187 125 3294 2226 M10717 GO_NEGATIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. 32/49 Gene Ontology BP GO:0014014 6.02591833339139e-07 1.01736567508237e-06 2605 2328.09090909091 2257 5.47810907629407e-08 1871 2.00740173500035 -1.44920976406866 -1 14.4453676813458 2602 2026 2017 1871 2714 2560 2001 2969 2255 2257 2337 2227 M12624 GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE.html A cascade of processes induced by the detection of DNA damage within a cell. 115/128 Gene Ontology BP GO:0042770 2.7391059211321e-07 5.86249303175147e-07 1895 2406.81818181818 2257 2.49009660196731e-08 1117 1.69822196645228 1.86572218857685 1 12.6963113149402 1895 3164 3274 3008 2114 1117 1527 2484 2018 3617 2257 2228 M14517 GO_CELLULAR_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 63/108 Gene Ontology BP GO:0071277 3.37358598982871e-07 6.78885086482941e-07 4620 2776.72727272727 2257 3.0668968246825e-08 730 2.6072080506037 -2.51195654183538 -1 19.3463167982002 4619 1890 765 2206 2257 4338 4060 3956 1992 730 3731 2229 M11349 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. 32/41 Gene Ontology BP GO:0030835 1.39682526705068e-06 1.96747037814481e-06 4035 2430.54545454545 2258 1.26984195811324e-07 414 2.15766107181506 -2.48389468779492 -1 14.786915083086 4031 2001 1955 1506 3273 4260 3201 935 414 2258 2902 2230 M11759 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 35/38 Gene Ontology BP GO:1903846 2.35467968780445e-07 5.3972042302237e-07 2260 2313.27272727273 2258 2.14061812711633e-08 1330 2.35050806031451 -1.82544495307165 -1 17.71459452641 2258 2903 1718 1330 1966 2374 1760 2819 1581 2315 4422 2231 M12814 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. 23/35 Gene Ontology BP GO:0045987 1.33701190954689e-07 4.20914507112428e-07 3945 2415.72727272727 2259 1.21546544618317e-08 877 3.21134674526713 -3.00593986208599 -1 24.6593610897306 3945 2123 877 2259 1378 3275 1500 3170 2936 1313 3797 2232 M13331 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. 35/38 Gene Ontology BP GO:0030511 2.35467968780445e-07 5.3972042302237e-07 2260 2301.27272727273 2259 2.14061812711633e-08 1331 2.35050806031451 -1.82544495307165 -1 17.71459452641 2259 2904 1719 1331 1967 2375 1761 2677 1582 2316 4423 2233 M13568 GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. 32/43 Gene Ontology BP GO:0048713 9.65616305646044e-08 4.02645553947883e-07 4585 2219.09090909091 2259 8.77833043662309e-09 273 2.95278918687268 3.63550057915262 1 22.7344725496963 4583 733 1243 637 961 3469 3589 3789 273 2259 2874 2234 M13744 GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 28/57 Gene Ontology BP GO:2000514 3.37618759965941e-07 6.78885086482941e-07 1230 2226.45454545455 2259 3.06926192525422e-08 1229 2.340022859118 -2.4911168373062 -1 17.3531662491354 1229 2574 1886 2517 2259 2741 2845 2154 2553 1716 2017 2235 M13245 GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. 17/23 Gene Ontology BP GO:2000310 5.99916268170308e-07 1.01484919564643e-06 3435 1973.54545454545 2260 5.45378574328241e-08 591 2.95565144754199 3.4066129327723 1 21.3215016595455 3433 963 624 1348 2707 2948 3367 2666 802 591 2260 2236 M14312 GO_ARGININE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARGININE_METABOLIC_PROCESS.html The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. 14/21 Gene Ontology BP GO:0006525 2.6857915685494e-06 3.50448350209208e-06 2260 2474.54545454545 2260 2.44163167946172e-07 1210 2.54571355138199 -2.67137578283244 -1 16.6929403109929 2260 2217 1320 1983 3536 2747 2424 4259 3665 1210 1599 2237 M12448 GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 23/29 Gene Ontology BP GO:0060099 1.49851713816988e-07 4.36901586057683e-07 3120 2379.63636363636 2262 1.36228840021864e-08 1369 2.93028566997741 -2.1567487321349 -1 22.4347575892289 3116 2610 1369 1798 1499 3335 2262 2421 1427 2021 4318 2238 M16139 GO_RENAL_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_FILTRATION.html A renal system process in which fluid circulating through the body is filtered through a barrier system. 9/13 Gene Ontology BP GO:0097205 4.86174717758902e-08 4.02645553947883e-07 3250 2191.90909090909 2262 4.86174728395365e-09 64 2.25236133093223 2.37865463975526 1 17.3172309648113 3247 1195 4596 78 301 4123 4515 2262 64 1334 2396 2239 M16582 GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 1235/1720 Gene Ontology BP GO:0010648 7.32649471659982e-08 4.02645553947883e-07 3265 2406.90909090909 2262 7.32649495814868e-09 264 1.99994119881761 2.24591596230283 1 15.364965895745 3265 1327 4637 852 740 2262 4295 3459 2119 264 3256 2240 M12180 GO_WATER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSPORT.html The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/21 Gene Ontology BP GO:0006833 1.99806689109695e-06 2.69634722861779e-06 2265 2261.72727272727 2263 1.81642609615276e-07 711 4.24372385027962 4.25979681424875 1 28.4802407093073 2263 2257 711 2175 3416 2465 1270 3076 3451 1354 2441 2241 M15230 GO_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that modulates the frequency, rate or extent of membrane invagination. 23/29 Gene Ontology BP GO:1905153 1.49851713816988e-07 4.36901586057683e-07 3120 2375.81818181818 2263 1.36228840021864e-08 1370 2.93028566997741 -2.1567487321349 -1 22.4347575892289 3117 2611 1370 1799 1500 3336 2263 2368 1428 2023 4319 2242 M10223 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein. 11/14 Gene Ontology BP GO:0042511 1.43464087039894e-07 4.29009252568525e-07 3795 2008.90909090909 2264 1.30421905813931e-08 143 2.07848376998616 1.27642810888156 1 15.9031919265831 3792 2264 2241 1407 1457 3068 2421 443 143 2374 2488 2243 M10478 GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of cholesterol homeostasis. 14/18 Gene Ontology BP GO:2000188 7.69353502569175e-06 9.2191652007581e-06 1700 2187 2264 6.99414720962514e-07 625 1.73745449127117 -1.39947242179675 -1 10.4775990067308 1697 3364 2982 2789 3858 1344 795 1373 625 2966 2264 2244 M13142 GO_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_IMPORT.html The directed movement of the hexose monosaccharide glucose into a cell or organelle. 14/18 Gene Ontology BP GO:0046323 7.07806477517038e-07 1.13998737967697e-06 3035 2160.54545454545 2264 6.43460641127158e-08 268 2.10994429376376 -1.32945741082298 -1 15.0624130120189 3032 3359 2264 1930 2847 2089 1833 1361 268 2487 2296 2245 M10433 GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of endocytosis. 135/190 Gene Ontology BP GO:0045807 7.0202902841086e-08 4.02645553947883e-07 2750 1959.72727272727 2265 6.38208228011725e-09 502 2.33831516516611 -2.17840871937307 -1 17.9820141844433 2746 1805 660 502 573 3044 2428 2622 2265 1146 3766 2246 M12823 GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 51/68 Gene Ontology BP GO:0051898 3.42333322334123e-08 3.99952679980378e-07 4075 2481.45454545455 2265 3.11212116055488e-09 92 1.86287219070435 -1.46961120512808 -1 14.3114140209881 4072 1902 2265 816 92 3821 3165 4309 1369 1249 4236 2247 M13807 GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. 83/130 Gene Ontology BP GO:0050728 1.33228489334562e-07 4.20399283289481e-07 2535 2123.63636363636 2265 1.21116815820607e-08 826 2.16570653839761 -1.83804966924459 -1 16.597945062673 2531 2434 1075 2265 1370 2026 1329 3408 2769 826 3327 2248 M11852 GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. 10/16 Gene Ontology BP GO:0048712 2.01103923650789e-06 2.71149393435851e-06 3270 2460.63636363636 2266 1.82821915892618e-07 695 3.53589846248889 4.51833643059788 1 23.7023466317976 3269 3597 1562 2266 3420 3680 3910 695 757 2149 1762 2249 M12849 GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. 4/14 Gene Ontology BP GO:0072283 9.78308732208279e-07 1.46651756796557e-06 2655 2416.18181818182 2266 9.78309162898132e-08 232 2.1636131925765 2.14713180166887 1 15.1619318810842 2653 1288 4390 1391 3135 1692 2145 3843 232 2266 3543 2250 M13699 GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 10/17 Gene Ontology BP GO:0010759 2.18742407600323e-06 2.91913396384951e-06 1280 2356.54545454545 2266 1.98856931902391e-07 130 2.2424831890174 2.38945320083516 1 14.9075677771113 1276 3849 1917 2542 3928 2266 2575 130 4081 2154 1204 2251 M12080 GO_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. 108/163 Gene Ontology BP GO:0042752 6.68060552830362e-08 4.02645553947883e-07 3585 2288.36363636364 2267 6.07327793742681e-09 93 1.86288571215588 -1.58364605984264 -1 14.3049528258998 3583 93 2267 1172 512 4193 3083 4425 1108 1503 3233 2252 M12118 GO_LEFT_RIGHT_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_PATTERN_FORMATION.html The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 25/39 Gene Ontology BP GO:0060972 8.91441444151428e-08 4.02645553947883e-07 4450 2548.45454545455 2268 8.10401345702451e-09 846 1.81295626949886 -1.71238129065782 -1 13.91878906788 4449 846 2082 1582 869 3196 3492 4582 2268 1300 3367 2253 M14491 GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE.html The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. 4/15 Gene Ontology BP GO:0007342 7.69487689566026e-07 1.21576442090007e-06 2475 1911.63636363636 2269 7.69487956016241e-08 15 5.440160504638 -4.83753532408724 -1 38.8146849469405 2473 2315 4497 142 2961 3135 1876 169 15 2269 1176 2254 M14821 GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 50/58 Gene Ontology BP GO:0010799 3.77590990536017e-08 4.02645553947883e-07 3820 2284 2269 3.43264542742451e-09 121 1.8710079333311 -1.74414459513313 -1 14.3677716214957 3819 478 2269 1209 121 3678 3358 3736 1094 2057 3305 2255 M15177 GO_INTRACELLULAR_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIPID_TRANSPORT.html The directed movement of lipids within cells. 37/57 Gene Ontology BP GO:0032365 6.2891177372811e-07 1.05074559538847e-06 3410 2363 2269 5.71738139558686e-08 1160 1.98041786750429 -1.37972373607896 -1 14.2162257214811 3410 1987 2883 1675 2743 3123 2257 1162 1160 3324 2269 2256 M11210 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 17/21 Gene Ontology BP GO:0009148 1.64056914529806e-07 4.50890031486821e-07 2015 2464 2270 1.49142660694317e-08 1605 1.0761497934763 1.07114391015079 1 8.15622294465474 2015 2633 3399 2500 1605 2270 2080 1962 1881 3695 3064 2257 M16522 GO_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. 187/270 Gene Ontology BP GO:0042594 8.31294067112355e-07 1.29408206566537e-06 2060 2306.54545454545 2272 7.5572216475098e-08 1009 2.18686283424115 -1.87850615741205 -1 15.4696437343214 2056 3884 1911 2272 2945 1009 1344 3152 2353 3292 1154 2258 M13750 GO_GLYCINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycine, aminoethanoic acid. 11/20 Gene Ontology BP GO:0006544 2.24218416175334e-06 2.98252798874737e-06 1505 2152.36363636364 2273 2.03835131539435e-07 1014 1.82585802667245 1.28471862829596 1 12.098197481445 1505 1206 2273 3675 3467 1264 1014 1287 2445 2382 3158 2259 M13777 GO_LONG_TERM_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_MEMORY.html The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. 32/45 Gene Ontology BP GO:0007616 3.42725780891833e-07 6.84715782949634e-07 2795 2329.72727272727 2273 3.11568940257446e-08 1011 2.60656757660472 3.17767563602116 1 19.3298308387206 2793 3238 1273 3163 2273 3213 4117 1011 1778 1141 1627 2260 M14370 GO_RESPONSE_TO_CORTICOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. 26/34 Gene Ontology BP GO:0051412 4.05747742873913e-06 5.11499389756792e-06 1940 2537.81818181818 2273 3.68862264726929e-07 1574 2.62462691158273 2.97968756525829 1 16.6923149690986 1937 3266 1670 2025 3665 2724 4333 1650 2273 2799 1574 2261 M14214 GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. 53/71 Gene Ontology BP GO:0043124 3.44853665736466e-07 6.88080663238326e-07 3065 2268.90909090909 2276 3.13503381629877e-08 1350 1.73607922825319 -1.81476838243203 -1 12.8355937991907 1350 2872 3063 2793 2276 1722 1726 2775 1776 3065 1540 2262 M14305 GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. 15/27 Gene Ontology BP GO:0035883 4.88651317228473e-06 6.08590626087818e-06 2460 1888.18181818182 2276 4.4422945690544e-07 28 2.20360297303546 -2.31677854402219 -1 13.7969800891746 2458 1089 2276 170 3712 2188 740 2542 28 2673 2894 2263 M11570 GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. 20/32 Gene Ontology BP GO:0002714 1.27559136228288e-06 1.82065233395775e-06 1395 2069 2277 1.15962918353595e-07 331 2.04281581607941 -2.13970212130106 -1 14.0775876697539 1391 3772 2552 3195 3224 1476 331 1242 2343 2277 956 2264 M12071 GO_HOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. 11/13 Gene Ontology BP GO:0050667 6.55337159641593e-07 1.08222129042779e-06 1560 2350.90909090909 2277 5.9576123168532e-08 1217 1.63562132915788 1.74409665597925 1 11.6978575519725 1557 2277 2831 2929 2774 2103 2227 1437 3170 3338 1217 2265 M13002 GO_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. 264/391 Gene Ontology BP GO:0046883 5.6081163214808e-08 4.02645553947883e-07 3970 2292.63636363636 2277 5.09828769494522e-09 92 2.17161069885959 2.28771343178505 1 16.6926902953339 3967 1590 318 92 347 3644 4223 3999 2277 231 4531 2266 M10691 GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION.html A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. 9/20 Gene Ontology BP GO:0060231 1.14239945418772e-06 1.65956436476287e-06 4535 2187.81818181818 2278 1.14240004147257e-07 148 2.65399497924606 -3.30080947806413 -1 18.4493263933891 4532 1207 4255 148 3214 2879 2501 2278 205 918 1929 2267 M16302 GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 126/167 Gene Ontology BP GO:0071260 2.1576060958912e-07 5.13521287170422e-07 2145 2416.81818181818 2278 1.96146027954013e-08 1401 2.12473041758376 2.3385503776222 1 16.0586636602264 2145 3156 1408 2350 1883 2091 3378 2843 3652 1401 2278 2268 M11966 GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 12/24 Gene Ontology BP GO:0045723 9.67339018181475e-05 0.000103710332986138 1145 2367.45454545455 2279 8.79437776957649e-06 630 2.06176547078721 -1.83816720545599 -1 9.83156479329576 1143 3590 2788 2067 4502 1784 2279 630 3490 2568 1201 2269 M12547 GO_ETHANOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. 13/17 Gene Ontology BP GO:0006067 8.7648240675564e-07 1.34729852614271e-06 2515 2384.63636363636 2279 7.96802505406714e-08 1060 2.7782613470944 -3.07827941764185 -1 19.6221722142736 2513 2216 1060 1912 2985 3347 4163 1514 2279 1810 2432 2270 M14225 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. 20/32 Gene Ontology BP GO:0002891 1.27559136228288e-06 1.82065233395775e-06 1395 2083 2279 1.15962918353595e-07 332 2.04281581607941 -2.13970212130106 -1 14.0775876697539 1392 3773 2553 3196 3225 1477 332 1385 2344 2279 957 2271 M15486 GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. 50/71 Gene Ontology BP GO:0035914 4.37950336557303e-07 8.11219313694718e-07 1865 2149.45454545455 2279 3.98136748853975e-08 854 2.41304366503256 -2.43908976111236 -1 17.6721781190438 1863 1911 854 2873 2466 2279 1906 2643 3192 994 2663 2272 M16019 GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. 9/17 Gene Ontology BP GO:0007171 2.04659383409902e-07 5.00119458251237e-07 3590 2205 2279 2.04659402258363e-08 416 2.54639447278373 1.65897291718112 1 19.3013917314521 3588 2279 4587 719 1933 2648 1736 2579 416 1333 2437 2273 M16109 GO_FEMALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. 20/23 Gene Ontology BP GO:0030540 4.48769771764435e-07 8.24043310189391e-07 2305 1979.36363636364 2280 4.07972603006662e-08 160 2.40630984850847 2.8488081010295 1 17.6027515264484 2303 957 1655 241 2484 2098 4042 2893 160 2280 2660 2274 M10971 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 41/75 Gene Ontology BP GO:0071379 1.62979966918984e-07 4.49256982271346e-07 2285 2675.27272727273 2281 1.48163617266214e-08 1225 2.4161592998861 -2.13847669367191 -1 18.445065683725 4297 1959 1225 2282 1601 3638 2101 3739 2281 1884 4421 2275 M11276 GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. 23/32 Gene Ontology BP GO:1901385 1.77142226767856e-07 4.6864496475983e-07 3740 2440.45454545455 2281 1.61038400937461e-08 730 2.65505658505779 -2.1555227314283 -1 20.2200785709023 3737 884 1493 3162 1678 3549 4334 2281 730 2020 2977 2276 M15996 GO_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_DUPLICATION.html The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 41/48 Gene Ontology BP GO:0051298 4.75926679638125e-07 8.54684230164491e-07 925 2172.63636363636 2281 4.32660711450475e-08 879 1.35186103547869 1.34524523830895 1 9.81815846836076 924 2886 3719 3018 2542 1128 971 879 2132 3419 2281 2277 M11735 GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. 13/17 Gene Ontology BP GO:0060389 6.47868157504213e-08 4.02645553947883e-07 1860 1953.54545454545 2283 5.88971069620905e-09 33 1.9275517752675 1.8755035572143 1 14.805092395233 1857 1149 2335 584 479 2652 3669 4153 33 2295 2283 2278 M15717 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. 95/166 Gene Ontology BP GO:0045638 1.12178775880743e-06 1.63370217268574e-06 1490 2469.36363636364 2284 1.01980757346488e-07 897 1.9709985618907 -2.06565549312188 -1 13.6912201689016 1486 3178 2284 3005 3164 2246 2164 897 3328 3536 1875 2279 M10227 GO_POSITIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA replication. 91/115 Gene Ontology BP GO:0045740 6.46177376157489e-07 1.07207164843688e-06 2290 2556.81818181818 2287 5.87434150864401e-08 1232 1.60501678831074 1.5299650833607 1 11.4849928956081 2287 1850 3226 2148 2760 1929 1232 3548 1767 3915 3463 2280 M12441 GO_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGY.html The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. 437/578 Gene Ontology BP GO:0006914 1.3832486289284e-07 4.24835370983751e-07 1220 2172.09090909091 2288 1.25749883263643e-08 145 1.79871341750095 -1.54016605051941 -1 13.7579511576971 1220 3407 3309 3429 1413 145 1066 2814 2288 4301 501 2281 M12896 GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. 226/332 Gene Ontology BP GO:0043903 2.11289221453171e-07 5.08602559452461e-07 1185 2326.72727272727 2288 1.92081128859553e-08 1183 1.73075661836442 -1.89601391641484 -1 13.0706772735899 1183 3422 3088 2934 1860 1889 1389 2288 2910 3180 1451 2282 M15297 GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 418/577 Gene Ontology BP GO:0051090 8.9496869631495e-08 4.02645553947883e-07 2355 2335 2288 8.13607938838758e-09 871 1.85865275199968 -1.89332083525964 -1 14.272214311018 2354 2770 2188 1667 871 2193 2372 3513 3235 2288 2234 2283 M16198 GO_ENDOTHELIAL_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 16/17 Gene Ontology BP GO:0061154 0.000393397961682267 0.000410145802309565 2290 2651.36363636364 2288 3.57698477856233e-05 994 1.13911724805647 1.20606519420043 1 4.56321211647915 2288 4051 3480 3094 4538 2175 1384 994 1492 4237 1432 2284 M12960 GO_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 37/45 Gene Ontology BP GO:0036314 1.03181497120848e-07 4.02645553947883e-07 2985 2575.90909090909 2289 9.38013654183009e-09 1049 2.29384830410254 2.30809122064079 1 17.6380990661912 2982 1992 1749 1857 1049 3497 4552 3235 2289 1980 3153 2285 M10210 GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 25/40 Gene Ontology BP GO:0045745 2.55755851735842e-07 5.65745344301423e-07 4025 2776.36363636364 2290 2.32505346789223e-08 690 2.04244055291001 2.06097352413419 1 15.3288316381215 4024 2063 1412 2290 2043 3855 4082 690 3966 1967 4148 2286 M14604 GO_FUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. 11/15 Gene Ontology BP GO:0006004 1.16900414114001e-05 1.36427797058552e-05 2110 2360.36363636364 2290 1.06273668442831e-06 267 1.18882317052566 -1.43528373573922 -1 6.8918822245964 2110 2265 3172 2942 4460 2626 1436 267 645 3751 2290 2287 M14318 GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. 106/121 Gene Ontology BP GO:0032231 4.77494138166492e-08 4.02645553947883e-07 2995 2352.36363636364 2291 4.34085589572872e-09 91 1.80061751113904 2.02671837887752 1 13.8233587757724 2994 91 1928 1614 214 3351 4584 4028 2291 2224 2557 2288 M14490 GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 37/45 Gene Ontology BP GO:0035412 9.23163309985689e-07 1.40604873367051e-06 3155 2150.45454545455 2291 8.39239724875832e-08 288 2.50316789147371 2.50779656545397 1 17.6129445973924 3155 588 826 902 3019 3096 4197 2291 288 1423 3870 2289 M15393 GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-glutamate across a membrane. 9/13 Gene Ontology BP GO:0089711 9.34286347407546e-07 1.41927338376994e-06 1090 2242.63636363636 2291 9.34286740208717e-08 329 2.8113341278003 2.09501347476174 1 19.780134688132 1087 2291 4550 3665 3106 1095 329 4284 714 2460 1088 2290 M16386 GO_SIGNAL_PEPTIDE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_PEPTIDE_PROCESSING.html The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. 25/30 Gene Ontology BP GO:0006465 1.66685118605849e-07 4.53963284590687e-07 2310 2200.09090909091 2291 1.5153193748628e-08 269 2.6889882919075 -2.92820181471932 -1 20.5247615102692 2306 2960 1528 1898 1622 2781 2176 3564 269 2291 2806 2291 M10361 GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. 9/20 Gene Ontology BP GO:0002861 3.44455874309602e-06 4.40801205490259e-06 1975 2446.54545454545 2292 3.4445640823509e-07 1316 1.86571583474193 -2.4809957669056 -1 11.9817287367992 1971 2292 4236 1433 3641 2952 1521 1316 2699 3023 1828 2292 M15793 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 20/22 Gene Ontology BP GO:0061003 3.27114635244191e-06 4.20692205027977e-06 875 2241.45454545455 2292 2.97377383297229e-07 250 1.60293650363229 1.70044314486734 1 10.3189555902102 874 2640 2849 3766 3594 2018 1423 250 2292 3061 1889 2293 M12858 GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 20/38 Gene Ontology BP GO:0051354 7.14069610981915e-07 1.1484845834424e-06 2675 2287.63636363636 2293 6.49154402502418e-08 817 2.10089940724951 -1.7490257815667 -1 14.98920779086 2671 2134 2247 2293 2851 2300 1771 4443 817 2648 989 2294 M15808 GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. 17/49 Gene Ontology BP GO:0045721 3.9748233394473e-07 7.54393074794667e-07 2295 1949.54545454545 2293 3.61347641599444e-08 206 1.86739050226597 1.98050706560447 1 13.7239803250391 2293 1033 1945 2407 2402 2905 2750 206 2470 1360 1674 2295 M11157 GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. 160/206 Gene Ontology BP GO:1901136 9.62938649318408e-08 4.02645553947883e-07 2320 1936.90909090909 2295 8.75398810423799e-09 737 2.18040442925533 2.61243282320924 1 16.7607026703159 2318 2380 1093 2641 957 2295 3535 1458 1569 737 2323 2296 M11202 GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/16 Gene Ontology BP GO:0032375 1.9785400081678e-07 4.93246485651519e-07 4015 2641.90909090909 2295 1.97854018432574e-08 355 2.41840510181948 -1.37012774939172 -1 18.3436487259864 4011 2295 4285 1558 1897 2816 1312 4320 355 1580 4632 2297 M15259 GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/16 Gene Ontology BP GO:0032372 1.9785400081678e-07 4.93246485651519e-07 4015 2666.09090909091 2296 1.97854018432574e-08 356 2.41840510181948 -1.37012774939172 -1 18.3436487259864 4012 2296 4545 1559 1898 2817 1313 4310 356 1588 4633 2298 M12830 GO_LYMPHANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHANGIOGENESIS.html Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. 13/15 Gene Ontology BP GO:0001946 1.99432622593958e-05 2.25945944224419e-05 4360 2346.09090909091 2297 1.8130402772491e-06 290 2.85808087082891 -2.31846147685004 -1 15.9561829010584 4358 1125 1496 739 4083 4390 3392 852 290 2297 2785 2299 M10485 GO_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLERANCE_INDUCTION.html A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. 8/14 Gene Ontology BP GO:0002507 4.27211821751263e-07 7.97679216135084e-07 2030 2315.90909090909 2299 4.27211903880758e-08 801 2.40245142551315 -2.9086899111829 -1 17.6153921569657 2028 1248 4244 801 2530 2651 2299 3472 2509 1578 2115 2300 M13441 GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. 36/46 Gene Ontology BP GO:0038034 3.39691745573398e-06 4.35063499078728e-06 1760 2329.36363636364 2299 3.08811154615202e-07 887 1.80128273939711 -1.90480413110791 -1 11.5767759547474 1759 3227 2758 2299 3607 1855 1741 2520 887 3004 1966 2301 M16202 GO_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 145/242 Gene Ontology BP GO:0044070 1.15541536779436e-07 4.08387002100415e-07 3685 2236 2299 1.05037766225044e-08 447 2.39423709660536 -2.12139827929764 -1 18.3967200294413 3684 1769 447 467 1203 3035 2829 3654 2299 792 4417 2302 M16454 GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 138/204 Gene Ontology BP GO:0032479 3.5202904326578e-07 6.95537638350604e-07 3615 2462.63636363636 2299 3.20026454177351e-08 1039 1.6348963735223 -1.64792305234885 -1 12.0722480115912 1330 3896 3439 3612 2299 1443 1039 1049 3732 3614 1636 2303 M14700 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. 36/46 Gene Ontology BP GO:0097192 3.39691745573398e-06 4.35063499078728e-06 1760 2361.45454545455 2300 3.08811154615202e-07 888 1.80128273939711 -1.90480413110791 -1 11.5767759547474 1760 3228 2759 2300 3608 1856 1742 2863 888 3005 1967 2304 M14935 GO_GLIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. 8/16 Gene Ontology BP GO:0021781 1.01841221897664e-05 1.19966381136666e-05 2570 2710.09090909091 2300 1.01841688624225e-06 892 1.87906809734123 -1.64450545726793 -1 11.0800760072476 2570 2300 4526 1438 3955 2287 892 4328 2190 2198 3127 2305 M15951 GO_ORGANELLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_LOCALIZATION.html Any process in which an organelle is transported to, and/or maintained in, a specific location. 495/627 Gene Ontology BP GO:0051640 1.65644738305538e-07 4.52287618430271e-07 3430 2428.27272727273 2300 1.505861370704e-08 1179 1.82397600411044 2.14514992656726 1 13.8926373466602 3428 1460 2279 1733 1615 3264 4083 2300 1179 2624 2746 2306 M12607 GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. 22/34 Gene Ontology BP GO:0002292 6.83508663016035e-07 1.11046292214162e-06 605 2349.27272727273 2301 6.21371704884121e-08 603 1.52194867330913 -1.61325066257117 -1 10.8571296539379 603 3752 3137 3499 2819 1459 928 1357 4144 1843 2301 2307 M15225 GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of MAP kinase activity. 249/335 Gene Ontology BP GO:0043406 7.72107879649956e-08 4.02645553947883e-07 3710 2083.81818181818 2301 7.01916278861555e-09 264 2.14610239152207 -1.96552861894472 -1 16.4954042192636 3709 1607 496 264 687 3472 2616 3771 2301 720 3279 2308 M15263 GO_OLIGODENDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DEVELOPMENT.html The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. 34/53 Gene Ontology BP GO:0014003 5.81477519400812e-07 9.91430889619633e-07 3650 2542.45454545455 2301 5.28616066445462e-08 423 2.95005558995351 3.59545174856137 1 21.3171133425579 3647 2000 1074 1343 2687 3670 4629 2301 423 2206 3987 2309 M11808 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. 24/26 Gene Ontology BP GO:1902116 1.23424150357076e-07 4.14338946095474e-07 2105 2235 2304 1.12203779346731e-08 451 1.26026431772492 1.28228597988683 1 9.62521526771682 2101 840 2986 2909 1272 809 451 3469 3983 3461 2304 2310 M13768 GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 69/88 Gene Ontology BP GO:0072527 3.53469880275104e-07 6.96609636984353e-07 755 2045.54545454545 2305 3.21336306424055e-08 751 1.63154480902669 1.79331594185528 1 12.0459688897744 751 2452 3001 2888 2305 1590 1618 1237 1463 2825 2371 2311 M14816 GO_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_DISASSEMBLY.html A process that results in the breakdown of the extracellular matrix. 70/149 Gene Ontology BP GO:0022617 6.56430953050662e-08 4.02645553947883e-07 2405 2089.81818181818 2306 5.96755429670088e-09 236 2.78430297476472 2.67956601920985 1 21.4313683013858 2403 1859 236 1241 2749 3150 3526 2306 1703 646 3169 2312 M10338 GO_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT.html Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 73/89 Gene Ontology BP GO:0046324 1.83647139821132e-07 4.7749337740829e-07 2310 2071.45454545455 2307 1.66951959228416e-08 570 1.91727482985107 -1.79927140592701 -1 14.5539182146962 2307 2449 2366 1866 1706 1735 2456 1501 2918 2912 570 2313 M15313 GO_SCHWANN_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 40/42 Gene Ontology BP GO:0014037 2.00744874422442e-07 4.95788694632496e-07 3565 2855.45454545455 2307 1.82495357036315e-08 1611 1.79131613997782 1.86747591601497 1 13.5556334295757 3565 1957 2254 1611 1807 4018 3600 4157 2243 2307 3891 2314 M15525 GO_CARDIAC_CHAMBER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_FORMATION.html The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. 12/19 Gene Ontology BP GO:0003207 3.54911324350696e-07 6.98858397039268e-07 4490 2753 2307 3.22646710551078e-08 1172 2.41041781395783 2.71775203427247 1 17.8415888952893 4489 1172 1628 1659 2307 4204 4284 4059 1391 1182 3908 2315 M13737 GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. 4/18 Gene Ontology BP GO:0021892 6.70111444139242e-07 1.09442911533166e-06 4485 2713.54545454545 2308 6.70111646211532e-08 325 3.06816616739384 -1.62548130065235 -1 22.0154233428477 4485 1290 4447 1396 2876 4433 2308 1401 325 2268 4620 2316 M12222 GO_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JAK_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. 108/201 Gene Ontology BP GO:0046425 7.28933944703792e-08 4.02645553947883e-07 4370 2570.36363636364 2309 6.62667244414387e-09 613 2.52087201033569 2.53637928052069 1 19.3939433715403 4367 1833 652 1626 613 4154 4198 3013 2309 1683 3826 2317 M15845 GO_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of STAT cascade. 108/201 Gene Ontology BP GO:1904892 7.28933944703792e-08 4.02645553947883e-07 4370 2576.27272727273 2310 6.62667244414387e-09 614 2.52087201033569 2.53637928052069 1 19.3939433715403 4368 1834 653 1627 614 4155 4199 3068 2310 1684 3827 2318 M10938 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 85/136 Gene Ontology BP GO:0042993 4.0208902756821e-07 7.61155510689537e-07 2270 2403.90909090909 2311 3.65535546415574e-08 1290 2.05914935737191 -1.90979647299646 -1 15.1341910879723 2267 2842 2311 3275 2410 2049 2303 1624 1290 3293 2779 2319 M11867 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT.html The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+. 23/52 Gene Ontology BP GO:0072488 4.78895743606225e-07 8.58359743836581e-07 2280 2242.63636363636 2312 4.35359861683843e-08 1257 2.21621148288588 -1.72325843034267 -1 16.1565086172097 2276 2975 2312 2085 2547 2472 1257 1529 1672 3095 2449 2320 M14726 GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT.html The directed movement of substances from early endosomes to the Golgi. 15/16 Gene Ontology BP GO:0034498 8.07299927150811e-08 4.02645553947883e-07 1725 2622.81818181818 2312 7.33909051613679e-09 744 1.20658777657395 -1.16210143289033 -1 9.22902039609233 1721 4056 3537 4496 744 2094 1171 1963 2732 4025 2312 2321 M12183 GO_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIVISION.html The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. 40/47 Gene Ontology BP GO:0017145 1.95331946651528e-07 4.93152223423526e-07 2970 2265.72727272727 2313 1.77574512722287e-08 538 1.99483927477767 1.77408474778325 1 15.1130618184693 2966 603 2313 1654 1765 2557 2569 4535 538 1480 3943 2322 M11540 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. 19/23 Gene Ontology BP GO:2000696 4.27456186144937e-07 7.97815336595424e-07 3810 2456.18181818182 2314 3.88596608362687e-08 999 2.26199845441029 2.75413851636053 1 16.5793329464086 3807 999 1701 1385 2444 4163 3547 2314 1963 2110 2585 2323 M13682 GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 4/19 Gene Ontology BP GO:0010919 3.39395237430687e-06 4.34923172614978e-06 3335 2516.18181818182 2314 3.39395755782874e-07 425 4.82208350094685 -4.46958320089268 -1 31.1648281649903 3335 2314 4444 922 3638 3856 2658 425 1659 2267 2160 2324 M14597 GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS.html A biological process that directly contributes to the process of producing new individuals, involving another organism. 781/1478 Gene Ontology BP GO:0044703 1.14329585227339e-07 4.07331975545794e-07 2345 2258.45454545455 2314 1.14329591109403e-08 602 2.0537075534463 2.10934382734012 1 15.7683227417422 2314 1391 4502 3131 1298 1747 2886 2286 2341 602 2345 2325 M15340 GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. 230/336 Gene Ontology BP GO:0002218 1.02952511628752e-06 1.5226544908406e-06 1030 2154.63636363636 2314 9.35932361882313e-08 1028 1.84036650841961 -2.09735860063188 -1 12.8450262436422 1028 3129 2349 1621 3108 2314 1699 1030 2680 3044 1699 2326 M15547 GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. 28/53 Gene Ontology BP GO:0045414 4.32348054544889e-07 8.03817365109898e-07 2460 2265.36363636364 2314 3.9304376319159e-08 616 2.51330967758964 -2.55206278063367 -1 18.4228651342868 2457 3978 1804 2314 2453 3211 2172 616 893 3043 1978 2327 M14129 GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. 282/476 Gene Ontology BP GO:0072507 6.7142127811688e-12 2.08274880471856e-10 3455 2183.45454545455 2315 6.10382980108116e-13 99 2.36519205074096 2.50196778981549 1 27.5901648692712 3453 1569 99 1249 418 2315 4565 4410 2881 121 2938 2328 M10874 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. 56/130 Gene Ontology BP GO:0002704 1.34823807764968e-06 1.91027764168817e-06 785 2189.54545454545 2316 1.22567173081685e-07 372 1.58281954166542 -1.35421989379899 -1 10.8444975418037 783 372 2316 2915 3253 1596 2603 1843 4110 2607 1687 2329 M11468 GO_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORELIMB_MORPHOGENESIS.html The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 34/58 Gene Ontology BP GO:0035136 5.06470674434691e-07 8.92064661031881e-07 1925 2166.54545454545 2316 4.60427991846672e-08 676 2.46081226819236 2.54884546245457 1 17.9012665567461 2363 676 1068 1923 2594 2316 2515 4553 2796 1922 1106 2330 M13444 GO_MALE_MEIOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. 35/155 Gene Ontology BP GO:0007140 5.3905054654021e-07 9.3519843141372e-07 865 2315.27272727273 2317 4.9004607147275e-08 430 1.78717048734065 1.85565364363024 1 12.9283261935522 865 3968 2694 3909 2634 557 430 2138 4218 2317 1738 2331 M14634 GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. 3/19 Gene Ontology BP GO:0021527 5.00115048009091e-05 5.48441036621801e-05 2920 2460.27272727273 2317 5.00126303543356e-06 573 2.79701522746339 2.01248034035529 1 14.3102991949606 2920 2317 4506 1953 4238 3056 2157 1041 573 1770 2532 2332 M14249 GO_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOR_SIGNALING.html Any process that modulates the frequency, rate or extent of TOR signaling. 83/108 Gene Ontology BP GO:0032006 1.41328490105418e-07 4.2854237685504e-07 1545 2451 2318 1.28480453803993e-08 620 1.40698913738423 -1.13825059492116 -1 10.7328984166776 1544 4389 3842 3118 1432 1154 620 2318 3611 4178 755 2333 M16092 GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 35/47 Gene Ontology BP GO:0009069 2.24614893529194e-06 2.98664621986978e-06 2080 2527 2318 2.04195566232831e-07 1712 1.61242139605497 1.49599205344747 1 10.6707550978533 2077 1984 2818 3171 3468 1712 1812 2204 3092 2318 3141 2334 M13034 GO_MULTIVESICULAR_BODY_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 34/34 Gene Ontology BP GO:0036257 3.60036126257352e-07 7.04774125147438e-07 85 1757.63636363636 2320 3.27305622889346e-08 22 1.07366071297814 -0.911778969291017 -1 7.88524114186672 83 2543 3800 3267 2320 33 22 506 2804 3918 38 2335 M15764 GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. 294/617 Gene Ontology BP GO:0002768 8.1628708881904e-08 4.02645553947883e-07 1550 2402.18181818182 2321 7.42079199187749e-09 764 1.61657051712826 -1.495993780094 -1 12.3999044955459 1549 2779 3447 2617 764 2015 1751 2321 3304 3903 1974 2336 M13146 GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that modulates I-kappaB kinase/NF-kappaB signaling. 308/420 Gene Ontology BP GO:0043122 1.58392557345398e-07 4.44738738572283e-07 1070 2128.27272727273 2322 1.43993244317389e-08 1066 1.85142838446541 -1.8137982777297 -1 14.1196502100828 1066 3122 2686 2937 1567 1245 1454 2463 2760 2322 1789 2337 M15994 GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 166/233 Gene Ontology BP GO:0043902 1.30850125632766e-07 4.19026589517727e-07 2285 2529.18181818182 2325 1.18954666741256e-08 1295 1.6107990239872 -1.60346756619999 -1 12.3215282343587 2284 2808 3350 3492 1351 2325 1831 2315 3734 3036 1295 2338 M16241 GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX.html The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. 13/13 Gene Ontology BP GO:0016558 2.63714943213664e-05 2.95607234587613e-05 1170 2432.09090909091 2325 2.39743731299133e-06 122 1.26405530430927 -0.762839888005173 -1 6.82116447555907 1168 3829 3550 3533 4508 1091 122 381 2325 4309 1937 2339 M13674 GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-13 production. 28/65 Gene Ontology BP GO:0032656 5.40030049862759e-06 6.66868317943582e-06 235 2334.36363636364 2326 4.90937614063074e-07 234 1.26281802506824 -1.26834982399484 -1 7.80202057797957 234 2035 3082 2579 3743 1363 1956 1690 3953 2717 2326 2340 M12425 GO_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMOCYTE_AGGREGATION.html The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. 45/63 Gene Ontology BP GO:0071594 1.3562081690425e-06 1.9180658390744e-06 2130 2319 2327 1.23291727735359e-07 1749 2.03218932296322 2.3587627454696 1 13.948187852807 2619 1950 2423 2126 3259 2327 2655 2127 1749 1774 2500 2341 M15082 GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. 482/608 Gene Ontology BP GO:0042326 1.04497459875004e-07 4.02645553947883e-07 2775 2027.09090909091 2327 9.49976953077392e-09 506 1.99340723792615 2.27634253299505 1 15.3144310057417 2774 2336 1358 3179 1067 643 3376 2516 2216 2327 506 2342 M16041 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 98/140 Gene Ontology BP GO:0090100 1.271184483749e-07 4.17034908558357e-07 3400 2153.90909090909 2327 1.15562232472679e-08 98 2.18856169899118 2.2791969738116 1 16.7834295359067 3400 98 614 1269 1310 2748 4574 3706 2327 540 3107 2343 M14256 GO_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_IN_THYMUS.html The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. 45/63 Gene Ontology BP GO:0033077 1.3562081690425e-06 1.9180658390744e-06 2620 2323.72727272727 2328 1.23291727735359e-07 1750 2.03218932296322 2.3587627454696 1 13.948187852807 2620 1951 2424 2127 3260 2328 2656 2168 1750 1776 2501 2344 M15024 GO_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOMINERAL_TISSUE_DEVELOPMENT.html Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. 84/111 Gene Ontology BP GO:0031214 1.42702395941271e-10 3.49470657007754e-09 2330 1855.54545454545 2328 1.29729450864115e-11 34 3.07224388206134 2.93534670474822 1 31.3180373963128 2328 165 132 34 2383 3409 4292 3396 947 522 2803 2345 M15508 GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. 29/31 Gene Ontology BP GO:0006760 3.36491292245538e-07 6.77789602951727e-07 1490 2249.36363636364 2329 3.05901221556446e-08 812 2.02152660397482 1.72340619155294 1 14.9789596745978 1488 812 2329 2861 2255 1867 2420 3541 911 2505 3754 2346 M15768 GO_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. 64/92 Gene Ontology BP GO:0048709 3.62795602325083e-07 7.08090577860156e-07 3750 2256.45454545455 2329 3.29814238320605e-08 302 2.87234995911562 3.30795682419044 1 21.2606799688071 3747 302 421 535 2329 3534 4481 2998 1198 786 4490 2347 M12105 GO_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_OLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 432/614 Gene Ontology BP GO:0051259 1.01619213017095e-07 4.02645553947883e-07 4075 2436.54545454545 2330 9.23811070099478e-09 497 2.05586271305026 2.11937212054497 1 15.797473469254 4074 1484 574 867 1031 4626 3665 4198 2330 497 3456 2348 M12842 GO_CILIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MORPHOGENESIS.html A process that is carried out at the cellular level and in which the structure of a cilium is organized. 238/309 Gene Ontology BP GO:0060271 3.81219541645714e-08 4.02645553947883e-07 615 1910.63636363636 2330 3.46563225683224e-09 126 1.64714420556935 1.53043472063571 1 12.63636718763 615 3128 3360 3881 126 178 475 2330 2971 2655 1298 2349 M13561 GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 23/31 Gene Ontology BP GO:2000463 5.95442123479866e-07 1.00932320602981e-06 3320 2022.90909090909 2331 5.41311167854199e-08 615 2.45363081903947 2.79136160361116 1 17.6895702980408 3320 821 840 615 2702 2331 2804 2970 1946 651 3252 2350 M11514 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION.html A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. 21/25 Gene Ontology BP GO:0000132 3.94309430199685e-07 7.51011780073326e-07 2045 2207 2332 3.58463182611269e-08 636 1.94738379446025 2.81215152170995 1 14.3208788100563 2041 2132 2590 3414 2393 2232 2567 636 2332 3171 769 2351 M13905 GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a neurophysiological process. 27/34 Gene Ontology BP GO:0031646 4.63808182049442e-07 8.41036426763855e-07 2335 2146.81818181818 2332 4.21643890754903e-08 598 3.57119359000912 4.07744404178085 1 26.1357186675501 2332 3260 894 2248 2515 2880 2954 598 1490 1935 2509 2352 M13687 GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 490/679 Gene Ontology BP GO:0009991 3.68416696615901e-10 8.28136661523569e-09 4255 2531.27272727273 2334 3.34924269706907e-11 140 2.37876896340583 2.59553391614701 1 23.1476675228497 4254 2334 140 1272 1952 4445 2865 3913 1825 874 3970 2353 M14998 GO_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 87/99 Gene Ontology BP GO:0051225 3.66630703537867e-07 7.1348082959502e-07 2345 2152.09090909091 2336 3.3330069512455e-08 164 1.52733961862791 1.75786811501361 1 11.2508314561097 1875 164 3047 2864 2336 2344 2343 1747 1827 2931 2195 2354 M15559 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 41/54 Gene Ontology BP GO:1901030 2.29791886146518e-07 5.31686547110765e-07 1790 2423 2336 2.08901736498619e-08 1128 1.54987204026705 1.79379636922275 1 11.657743017787 1788 3220 3189 3314 1948 1429 2022 2336 1128 3628 2651 2355 M13817 GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. 15/19 Gene Ontology BP GO:1900745 3.49010260154318e-07 6.93400828564493e-07 4145 2512.09090909091 2337 3.17282105019706e-08 735 2.47789219077829 2.37895915968979 1 18.3541106978742 4143 3342 1681 2032 2284 3194 3211 735 2337 1781 2893 2356 M16788 GO_LEUKOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. 64/87 Gene Ontology BP GO:0001776 6.86583601626953e-08 4.02645553947883e-07 4485 2483.63636363636 2337 6.24166930049174e-09 324 1.81029306960459 1.79825888482871 1 13.8981913759211 4482 324 2337 1008 540 4477 3285 3178 1343 2191 4155 2357 M11135 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 74/148 Gene Ontology BP GO:0003073 3.9544608378773e-08 4.02645553947883e-07 3840 2071.54545454545 2338 3.59496446268911e-09 136 2.30934460547251 2.38858445172996 1 17.757950393464 3838 270 836 2837 136 4493 2703 948 3437 951 2338 2358 M12549 GO_PROTEIN_HETEROTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTRIMERIZATION.html The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. 27/31 Gene Ontology BP GO:0070208 0.00441363629482815 0.00450167682591744 340 2441.90909090909 2338 0.000402046897676042 336 2.84454195037877 3.05691097845874 1 7.96986041264078 336 3270 1120 1881 4545 2338 3420 3179 3354 1554 1864 2359 M14659 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. 18/28 Gene Ontology BP GO:2000679 1.02720878322254e-05 1.20910763175676e-05 630 2070.36363636364 2339 9.33830526750992e-07 626 1.59898360322069 -1.87401444294104 -1 9.40660351724316 626 2651 2611 3478 3925 868 677 1009 3873 2339 717 2360 M13154 GO_CELLULAR_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 47/64 Gene Ontology BP GO:0071320 4.7570191291136e-08 4.02645553947883e-07 3310 2252.09090909091 2341 4.32456293815795e-09 211 2.07647672088452 -2.27696240296083 -1 15.9569061067823 3310 2495 1676 2216 211 3751 2904 2341 504 2007 3358 2361 M13620 GO_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 108/167 Gene Ontology BP GO:0032368 3.69161768302646e-07 7.16010716095128e-07 3245 2251.63636363636 2343 3.35601663862093e-08 95 2.21424018775104 -1.55272334296742 -1 16.3529298467864 3243 95 1111 993 2343 3098 1781 3194 3347 1125 4438 2362 M14878 GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. 162/266 Gene Ontology BP GO:0050866 1.71242306344122e-07 4.59245216956312e-07 2345 2211.63636363636 2343 1.55674836066529e-08 255 2.14986165407403 -2.04464269967264 -1 16.3759604473243 2343 1728 402 1938 1652 3091 3235 3323 3135 255 3226 2363 M16709 GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 328/469 Gene Ontology BP GO:0071214 1.8044513823778e-07 4.72066258868601e-07 2910 2370.45454545455 2343 1.6404104821635e-08 1398 2.02006687770359 2.30033591743836 1 15.3518547497231 2908 2343 1410 1853 1696 2798 4173 1398 3379 2352 1765 2364 M12729 GO_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. 845/1026 Gene Ontology BP GO:0009894 1.04367032121101e-07 4.02645553947883e-07 1910 2641.72727272727 2344 1.04367037022716e-08 1194 1.47165541707668 -1.3844718392768 -1 11.2791036884119 1907 3403 4383 3640 1194 1441 1973 2344 3006 4435 1333 2365 M13318 GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. 16/31 Gene Ontology BP GO:1901623 1.19398463672546e-06 1.72000325531999e-06 2345 2045.45454545455 2345 1.0854411679324e-07 773 3.0860025877358 -2.76904574183752 -1 21.4112190425355 2345 1060 968 773 3190 2906 2612 2858 1291 1225 3272 2366 M10447 GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. 72/77 Gene Ontology BP GO:2000573 1.01538634079077e-06 1.50608627468901e-06 1220 2352.18181818182 2346 9.23078917665195e-08 609 1.61610896253254 1.58418233773488 1 11.2765387892233 1218 3915 3304 3625 3097 637 609 2346 1144 4015 1964 2367 M16622 GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE.html Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. 33/40 Gene Ontology BP GO:0043094 2.43445091597785e-07 5.51658183480627e-07 1575 2690.36363636364 2346 2.21313744124235e-08 1502 1.29203665629436 1.34145131960857 1 9.67621905004551 1573 3716 3556 4491 1990 1861 1634 1502 3694 3231 2346 2368 M15192 GO_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 65/99 Gene Ontology BP GO:0043331 5.01855196522684e-08 4.02645553947883e-07 1735 2646.90909090909 2347 4.56232007246185e-09 249 1.66314726185556 -1.92824997300935 -1 12.760137853322 1734 3469 3563 4391 249 2060 1978 1984 3340 4001 2347 2369 M14762 GO_RHYTHMIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_PROCESS.html Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. 302/434 Gene Ontology BP GO:0048511 1.17899237983717e-07 4.08807542125352e-07 4335 2634.36363636364 2348 1.0718113118364e-08 686 2.07924381468648 2.32411876746238 1 15.9617208427001 4333 2348 893 1510 1223 4427 3453 4303 2077 686 3725 2370 M15280 GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. 1586/2144 Gene Ontology BP GO:0071822 8.74627401778489e-08 4.02645553947883e-07 2265 2621.18181818182 2349 8.7462743620228e-09 955 1.84407893981392 2.00352837919213 1 14.1594976896652 2264 2760 4546 4095 955 1625 2349 3101 2084 2026 3028 2371 M16328 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. 43/69 Gene Ontology BP GO:0051155 1.95115739597713e-07 4.93024708629241e-07 3950 2700.45454545455 2349 1.77377960820299e-08 849 2.31682088690583 1.75724672834001 1 17.5693530809072 3946 1956 1623 1546 1763 4391 4610 3982 849 2349 2690 2372 M16568 GO_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_AGING.html Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 46/53 Gene Ontology BP GO:0090342 2.64635378052284e-07 5.73520453692257e-07 2610 2484.36363636364 2349 2.40577645349966e-08 1383 1.659574911956 2.14017172014594 1 12.4241681020619 2610 3697 3040 2612 2085 2349 2328 1383 1725 3755 1744 2373 M14807 GO_CARDIOLIPIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOLIPIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. 14/15 Gene Ontology BP GO:0032048 1.69524587869304e-06 2.33360707052343e-06 2435 2287.45454545455 2350 1.54113380453982e-07 656 1.54679514284403 -1.14919612333885 -1 10.4327160334897 2435 1136 2931 2948 3349 2350 1463 1859 656 3721 2314 2374 M11192 GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 61/108 Gene Ontology BP GO:0051055 8.61029248917986e-08 4.02645553947883e-07 2000 2165.09090909091 2351 7.82753893287898e-09 834 1.83391276794078 -1.50801095051042 -1 14.0808705925799 1996 2468 2043 2526 834 1528 1277 3322 2627 2351 2844 2375 M14252 GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. 195/250 Gene Ontology BP GO:0006575 1.06385007273775e-07 4.02645553947883e-07 3300 2551.45454545455 2353 9.67136476529242e-09 1091 1.82133103737539 -2.01007813522367 -1 13.9835611074551 3300 1674 1935 2353 1091 4256 3781 2927 1890 1257 3602 2376 M14749 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN.html An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. 31/224 Gene Ontology BP GO:0002455 2.43521579383023e-07 5.51658183480627e-07 1160 2327.81818181818 2353 2.21383278489843e-08 828 3.19353590276245 -3.88274779703395 -1 24.0683009770473 1158 3508 828 3365 1991 2969 2353 2777 3405 2124 1128 2377 M10578 GO_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LOCALIZATION.html Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. 267/339 Gene Ontology BP GO:0051648 2.45366146213016e-07 5.54217805014158e-07 2655 2500.18181818182 2354 2.23060157798839e-08 1138 1.85170846291959 -1.55475940486836 -1 13.9077650544128 2655 2354 2384 1750 1997 2216 2014 4610 1138 2964 3420 2378 M12182 GO_BIOTIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOTIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. 12/13 Gene Ontology BP GO:0006768 3.78143579750925e-05 4.18331449496208e-05 1700 2268.81818181818 2354 3.43772799608606e-06 54 1.79338568580661 -1.39556194701319 -1 9.393595892417 1700 3587 2896 2729 4590 1726 1049 446 54 3826 2354 2379 M10295 GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 17/24 Gene Ontology BP GO:0009084 6.18855056627442e-07 1.03804346737112e-06 2660 2529.54545454545 2355 5.62595664281862e-08 1048 1.99060185137778 1.60852848920429 1 14.3025759755414 2658 1048 2306 3676 2732 2144 2196 2104 2355 2590 4016 2380 M10777 GO_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MATURATION.html Any process leading to the attainment of the full functional capacity of a protein. 272/391 Gene Ontology BP GO:0051604 1.01907362020432e-07 4.02645553947883e-07 4410 2914.27272727273 2356 9.26430606735791e-09 832 2.23734311774493 2.2071613540776 1 17.2010772620153 4406 2356 832 2196 1037 4647 3884 4365 2144 1852 4338 2381 M12734 GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 26/45 Gene Ontology BP GO:0042036 2.29087481208192e-07 5.30584395252223e-07 2200 2434.27272727273 2357 2.08261368239299e-08 612 1.85211320944602 -2.01187999667349 -1 13.9532206404956 2198 3263 2151 2678 1945 2875 2357 3462 3796 1440 612 2382 M11399 GO_MULTICELLULAR_ORGANISMAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MOVEMENT.html Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. 44/75 Gene Ontology BP GO:0050879 3.74054002088367e-07 7.22188079550694e-07 3420 2365.90909090909 2358 3.40049150624313e-08 490 1.73377669117543 -1.33147044579139 -1 12.774377273449 2174 2502 2654 2044 2358 2058 989 3418 490 3420 3918 2383 M15233 GO_MUSCULOSKELETAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCULOSKELETAL_MOVEMENT.html The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. 44/75 Gene Ontology BP GO:0050881 3.74054002088367e-07 7.22188079550694e-07 2175 2341.63636363636 2359 3.40049150624313e-08 491 1.73377669117543 -1.33147044579139 -1 12.774377273449 2175 2503 2655 2045 2359 2059 990 3140 491 3422 3919 2384 M13132 GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. 241/319 Gene Ontology BP GO:0043523 1.47952047612688e-07 4.36901586057683e-07 3745 2625.36363636364 2360 1.34501870511456e-08 1457 1.81611316215285 -1.5168425582064 -1 13.865319076004 3745 2360 2278 1457 1478 3310 2198 3155 1679 2697 4522 2385 M11957 GO_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING.html The series of events that restore integrity to a damaged tissue, following an injury. 476/666 Gene Ontology BP GO:0042060 3.61253964281641e-10 8.15978007671105e-09 4455 2311.90909090909 2363 3.28412694855419e-11 139 2.20118016471677 2.35786898533583 1 21.4289746405701 4455 1464 139 1266 551 4555 3134 3316 2363 234 3954 2386 M13302 GO_ONE_CARBON_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_METABOLIC_PROCESS.html The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. 29/37 Gene Ontology BP GO:0006730 8.35208982762385e-07 1.29843882285111e-06 1885 2225.36363636364 2363 7.59281181674241e-08 759 1.97818309917794 1.55878753193174 1 13.9801478517058 1885 759 2164 2841 2950 2363 2709 2400 1132 1875 3401 2387 M12146 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. 62/127 Gene Ontology BP GO:0001910 3.75897906544773e-07 7.24545550601834e-07 2025 2173.27272727273 2364 3.41725427974285e-08 311 1.7959176594086 -1.40201648061804 -1 13.2328447041319 2021 311 1512 2431 2364 1820 2508 3269 4013 1214 2443 2388 M12376 GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. 46/52 Gene Ontology BP GO:0061098 2.31338988124317e-06 3.06149121655986e-06 3110 2238.54545454545 2364 2.10308392170066e-07 528 2.1929479053607 -2.32003476122899 -1 14.5211494062478 3107 528 1319 1617 3481 2893 2364 3959 1125 1219 3012 2389 M15758 GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY.html Any process that initiates the activity of an inactive protein kinase. 312/415 Gene Ontology BP GO:0032147 5.91427871068913e-08 4.02645553947883e-07 3355 2025.09090909091 2364 5.37661715425745e-09 208 2.09380139733176 -2.01842072084046 -1 16.0908984328994 3351 1549 498 208 394 3749 3117 3481 2364 690 2875 2390 M14902 GO_ORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSPORT.html The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. 9/23 Gene Ontology BP GO:0015695 5.52490422186929e-06 6.813511620556e-06 3050 2588.45454545455 2365 5.52491795797235e-07 843 2.45841860981165 -2.82686998188007 -1 15.2584890241199 3050 1242 4522 2365 3779 3402 1770 3364 843 1905 2231 2391 M15548 GO_CELL_VOLUME_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_VOLUME_HOMEOSTASIS.html Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. 33/45 Gene Ontology BP GO:0006884 3.21702942701123e-07 6.55952582115831e-07 2935 2043 2368 2.92457263403006e-08 196 2.9867851164197 3.19291653826355 1 22.2317972653114 2933 649 636 845 2225 3083 2812 4006 196 2368 2720 2392 M10364 GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. 56/86 Gene Ontology BP GO:0048641 2.73873469644537e-07 5.86249303175147e-07 2115 2939.72727272727 2369 2.48975912489534e-08 403 1.82414899572947 2.02984921007877 1 13.6454062909289 4299 403 2369 1639 2113 4225 4616 4457 2113 1938 4165 2393 M10375 GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-alpha-amino acid across a membrane. 22/33 Gene Ontology BP GO:1902475 1.06289085467838e-05 1.2482663167134e-05 2085 2662.36363636364 2369 9.66269081710141e-07 1487 2.27540402029125 2.08402355889528 1 13.3913552687261 2083 3279 1895 3661 3937 2369 1487 4004 1491 1840 3240 2394 M12685 GO_PROTEIN_K11_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K11_LINKED_UBIQUITINATION.html A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. 30/35 Gene Ontology BP GO:0070979 3.8018340637946e-07 7.30998609067291e-07 525 2255.09090909091 2370 3.4562133825383e-08 125 0.805147010023557 0.838561567711656 1 5.87200838310796 521 2940 3975 4538 2370 226 125 950 4163 4160 838 2395 M16768 GO_MULTI_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_BEHAVIOR.html Any process in which an organism has a behavioral effect on another organism of the same or different species. 67/106 Gene Ontology BP GO:0051705 4.51511179384807e-07 8.26903161973583e-07 3705 2468.81818181818 2372 4.10464792772305e-08 317 2.03556229630507 2.28825541071899 1 14.8710744207707 3704 317 1697 1800 2490 3157 4631 2892 2372 2013 2084 2396 M10058 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 38/48 Gene Ontology BP GO:0042992 1.28174205949594e-07 4.17034908558357e-07 1645 2361 2374 1.16522012197411e-08 604 1.55451590994531 -1.53251398382396 -1 11.8912929390676 1644 3708 3471 3810 1320 1360 604 2374 2645 3954 1081 2397 M13911 GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 266/357 Gene Ontology BP GO:0051091 7.9311318881557e-08 4.02645553947883e-07 3105 2311.36363636364 2375 7.21012015825252e-09 718 1.90452647898959 -2.00115564568799 -1 14.6270103965759 3101 1604 1829 827 718 3547 3182 3144 3291 1807 2375 2398 M14417 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. 50/115 Gene Ontology BP GO:0002707 1.08153917097247e-06 1.58450937107522e-06 1025 2371.72727272727 2376 9.8321791151538e-08 447 1.57905374641718 -1.29218225718766 -1 10.9735228208474 1024 447 2353 2940 3141 1877 3216 2376 4167 2536 2012 2399 M15120 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. 108/134 Gene Ontology BP GO:0002495 8.46326416820383e-08 4.02645553947883e-07 3465 2087.54545454545 2376 7.69387681252763e-09 71 1.73564178255155 1.82227935624662 1 13.3208241950485 3461 71 2620 2376 800 2600 2584 2235 1184 1850 3182 2400 M14444 GO_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. 171/217 Gene Ontology BP GO:0035303 7.68281729742148e-08 4.02645553947883e-07 2380 2385.63636363636 2377 6.98437960520002e-09 682 1.65339758498877 -1.39111223726042 -1 12.6847320074322 3081 2377 3288 1843 682 2377 1570 2810 2112 3432 2670 2401 M15609 GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. 16/18 Gene Ontology BP GO:0051044 5.20423037460855e-05 5.68968137524755e-05 2380 2308.72727272727 2377 4.73123044349037e-06 376 2.26081131303831 -2.13697703335627 -1 11.5035622095775 2377 2670 2387 2007 4229 2200 1498 2093 376 2420 3139 2402 M10857 GO_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ACTIVATION.html A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. 162/224 Gene Ontology BP GO:0030168 1.87175563739132e-07 4.82197350765291e-07 4160 2466.27272727273 2378 1.70159617876358e-08 534 2.25476285549303 -1.79871090216669 -1 17.1222829970073 4158 2378 534 949 1723 4395 3041 3748 1758 1245 3200 2403 M16926 GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 40/56 Gene Ontology BP GO:0002312 3.65836824927224e-07 7.12531915607523e-07 2685 2418.72727272727 2378 3.32578987056408e-08 890 1.99008163222487 1.90934742509801 1 14.6921092943319 3860 2510 1814 1160 2334 4257 2378 2683 890 2035 2685 2404 M13037 GO_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_CYCLE.html The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. 57/66 Gene Ontology BP GO:0007098 7.37560349674313e-07 1.17509377491192e-06 615 2069.09090909091 2379 6.7050963358637e-08 397 1.35074088250869 1.38415096378464 1 9.58406755237134 611 2864 3767 3021 2877 684 397 1071 2379 3157 1932 2405 M13501 GO_POSITIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_RESORPTION.html Any process that activates or increases the frequency, rate or extent of bone resorption. 11/15 Gene Ontology BP GO:0045780 5.12184388176089e-05 5.60487760626374e-05 2055 2488.54545454545 2379 4.65633011622815e-06 548 3.28972284377955 -4.44864897496702 -1 16.811720725883 2053 3838 1611 3150 4224 2379 548 1264 4206 2381 1720 2406 M14984 GO_POSITIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_REMODELING.html Any process that activates or increases the frequency, rate or extent of bone remodeling. 11/15 Gene Ontology BP GO:0046852 5.12184388176089e-05 5.60487760626374e-05 2055 2484.54545454545 2380 4.65633011622815e-06 549 3.28972284377955 -4.44864897496702 -1 16.811720725883 2054 3839 1612 3151 4225 2380 549 1206 4207 2386 1721 2407 M10397 GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 168/214 Gene Ontology BP GO:0046488 6.16818645293243e-07 1.03500077769544e-06 2385 2130.54545454545 2381 5.6074438021096e-08 360 1.71667211770987 -1.6612472061069 -1 12.3228554626891 1512 2381 2916 2114 2730 693 1903 2789 2381 3657 360 2408 M13973 GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 35/45 Gene Ontology BP GO:0061036 1.91486232063769e-07 4.89015059161756e-07 3860 2606.18181818182 2381 1.7407840793689e-08 1736 1.99060623918432 -1.84620390716699 -1 15.0895817546517 3856 2901 1912 1801 1741 3494 2117 2381 2407 1736 4322 2409 M14562 GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 23/34 Gene Ontology BP GO:0045663 9.98192015087202e-08 4.02645553947883e-07 4345 2517.54545454545 2381 9.07447327615942e-09 422 1.89198321472062 -1.24114115192318 -1 14.5299984170669 4342 2105 2381 3696 999 3609 2256 422 1394 2734 3755 2410 M16892 GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. 14/20 Gene Ontology BP GO:0042789 2.25973968004277e-07 5.25330762845858e-07 2385 2545.90909090909 2382 2.05430901104814e-08 1201 2.31739605462828 2.32571694886929 1 17.4964876285923 2382 3807 2318 1382 1935 3716 3905 3416 1201 2499 1444 2411 M12431 GO_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MEMBRANE.html A process in which a protein is transported to, or maintained in, a specific location in a membrane. 441/589 Gene Ontology BP GO:0072657 5.73132586128433e-08 4.02645553947883e-07 2385 2449.81818181818 2383 5.21029637326717e-09 361 1.76170679220647 -1.39572089596267 -1 13.5224159121905 2383 3409 3429 2312 361 1779 1266 3085 1688 4143 3093 2412 M11724 GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 157/222 Gene Ontology BP GO:0070304 3.60590326379789e-07 7.04969238926536e-07 2845 2472.45454545455 2384 3.27809441347499e-08 1449 1.83594520352399 -1.72584334615044 -1 13.5564867212636 2842 2384 2037 1668 2323 2729 2282 2861 3535 1449 3087 2413 M13083 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. 37/42 Gene Ontology BP GO:0032105 8.34157912148637e-07 1.2976719375552e-06 3350 2581.90909090909 2388 7.58325662209418e-08 643 1.79250458576108 -1.35393082303881 -1 12.6588193017772 3346 643 2095 2286 2947 3613 3862 2126 2388 2854 2241 2414 M11391 GO_POSITIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BEHAVIOR.html Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 14/31 Gene Ontology BP GO:0048520 2.8899761234112e-06 3.74987699448754e-06 1175 2342 2389 2.62725447251322e-07 692 2.06364379284075 2.43085181438812 1 13.4390223330958 1174 3362 2088 2311 3561 2389 3124 1456 3120 2485 692 2415 M16865 GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. 150/178 Gene Ontology BP GO:0071901 8.44851781430795e-08 4.02645553947883e-07 3590 2241.54545454545 2389 7.68047103522811e-09 797 1.98691720538211 2.26157940706745 1 15.2642358658902 3586 2389 2101 2722 797 2044 3494 3015 1090 2473 946 2416 M16938 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. 37/42 Gene Ontology BP GO:0032108 8.34157912148637e-07 1.2976719375552e-06 3350 2562.09090909091 2389 7.58325662209418e-08 644 1.79250458576108 -1.35393082303881 -1 12.6588193017772 3347 644 2096 2287 2948 3614 3863 1898 2389 2855 2242 2417 M10527 GO_RESPONSE_TO_COLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COLD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. 62/78 Gene Ontology BP GO:0009409 6.74024085351141e-07 1.09911801128685e-06 2645 2603.54545454545 2390 6.1274935623189e-08 1220 2.08455940863618 -1.86328488292061 -1 14.9199306191673 2645 3923 2256 3969 2807 2390 1220 1643 3889 2222 1675 2418 M14396 GO_MRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION.html The cellular synthesis of messenger RNA (mRNA) from a DNA template. 26/33 Gene Ontology BP GO:0009299 3.93663379719273e-07 7.50765215604951e-07 2325 2808.81818181818 2390 3.57875863782354e-08 1615 2.05289404236813 2.13216680174366 1 15.102723697721 2323 3987 2941 2320 2390 3744 4102 2197 2157 3121 1615 2419 M13282 GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition. 179/212 Gene Ontology BP GO:1902806 3.5137139579892e-07 6.95537638350604e-07 2315 2536.90909090909 2391 3.1942859265269e-08 1586 1.82453766839031 1.92705651179625 1 13.4845221059329 2311 3140 3107 3485 2292 1586 1780 3002 1698 3114 2391 2420 M10132 GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION.html Any process that set the alignment of spindle relative to other cellular structures. 28/33 Gene Ontology BP GO:0051294 7.95884854761622e-08 4.02645553947883e-07 2210 2214.36363636364 2392 7.23531712321834e-09 724 1.79299166692254 2.33980084379742 1 13.7643790535082 2209 831 2711 3867 724 2392 3187 959 2896 3294 1288 2421 M10260 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. 108/134 Gene Ontology BP GO:0002504 8.46326416820383e-08 4.02645553947883e-07 3460 2100.90909090909 2392 7.69387681252763e-09 70 1.73564178255155 1.82227935624662 1 13.3208241950485 3460 70 2619 2375 799 2599 2583 2392 1183 1849 3181 2422 M12017 GO_ORGANOPHOSPHATE_ESTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSPORT.html The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. 80/106 Gene Ontology BP GO:0015748 2.63147690071316e-07 5.72429266901279e-07 2800 2117.27272727273 2392 2.39225201406452e-08 217 1.95283012462757 -1.79751883515084 -1 14.6397274509407 2799 217 2392 2835 2078 2571 2842 2934 790 1452 2380 2423 M12115 GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY.html The formation or destruction of chromatin structures. 133/208 Gene Ontology BP GO:0006333 2.68033785199807e-06 3.50031210366181e-06 270 1878.45454545455 2392 2.436673743231e-07 101 1.69510866724955 1.75430098759695 1 11.0819502214943 268 2392 3151 3422 3533 101 280 1160 3073 2744 539 2424 M13906 GO_TRACHEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_DEVELOPMENT.html The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. 22/31 Gene Ontology BP GO:0060438 1.36740994899211e-06 1.93038789219061e-06 2395 2473.27272727273 2392 1.24310072627861e-07 667 1.63170570516307 1.83717118910671 1 11.1736399915132 2392 2627 3184 667 3266 1284 2204 3773 2131 3567 2111 2425 M15704 GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. 245/343 Gene Ontology BP GO:0043123 2.18956922357666e-07 5.15590364235942e-07 1470 2462.27272727273 2392 1.9905176740868e-08 1416 1.86183116492462 -1.76612185301174 -1 14.0550056495553 1466 3417 2811 3459 1907 1432 1416 3391 3110 2284 2392 2426 M16735 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL.html The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. 35/73 Gene Ontology BP GO:0003044 1.6742891318777e-08 2.58819512645413e-07 4075 2365.27272727273 2393 1.52208104056338e-09 9 2.31541089895158 2.24472364782591 1 18.3423090795612 4071 671 967 3386 9 4565 2393 2256 3871 841 2988 2427 M11379 GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY.html The initiation of the activity of the inactive enzyme JUN kinase (JNK). 40/58 Gene Ontology BP GO:0007257 1.36394933249318e-07 4.23928240920297e-07 1680 2761.09090909091 2394 1.23995401550446e-08 1395 1.36822304465787 -1.50146894293834 -1 10.4421228664459 1679 3700 3388 3999 1395 2394 1440 1788 4534 3760 2295 2428 M16252 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. 118/208 Gene Ontology BP GO:1902106 1.36216775981307e-06 1.9235710429166e-06 535 2195.63636363636 2394 1.23833509383941e-07 533 1.84672538619976 -1.88834344055846 -1 12.663056481212 533 3160 2394 3045 3265 1540 1648 811 3434 2827 1495 2429 M12732 GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 72/101 Gene Ontology BP GO:0050805 3.94831614104265e-07 7.51391206718668e-07 3585 2692.45454545455 2395 3.58937895422076e-08 1233 2.35830641680913 2.91704996900681 1 17.3638652096916 3585 1867 1233 1310 2395 3164 3020 4565 1966 2214 4298 2430 M16196 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. 90/124 Gene Ontology BP GO:0033138 4.14546055083015e-08 4.02645553947883e-07 150 1948.63636363636 2395 3.76860057176643e-09 147 2.09585838134093 2.14137989880023 1 16.1068075364843 3340 147 1267 979 147 2643 3053 3205 649 2395 3610 2431 M10325 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. 23/25 Gene Ontology BP GO:0061339 3.9537661068322e-07 7.51678497490126e-07 4480 2672.81818181818 2397 3.5943334703545e-08 805 1.98369947509018 2.0881139037752 1 14.5889363890581 4478 893 1875 1123 2397 4226 2771 4290 805 2017 4526 2432 M10609 GO_SODIUM_ION_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_EXPORT.html The directed movement of sodium ions out of a cell or organelle. 10/15 Gene Ontology BP GO:0071436 9.93067196059941e-07 1.48386052128032e-06 3185 2502.63636363636 2397 9.0278876756816e-08 1092 2.53654479461309 2.34672070625221 1 17.7774044659603 3184 1202 1092 1752 3076 2397 2794 4459 2236 1151 4186 2433 M13291 GO_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 34/76 Gene Ontology BP GO:0042446 4.63133845966802e-07 8.40141046894164e-07 1600 2459.72727272727 2397 4.2103085769421e-08 1055 1.97978413749738 -1.54430459622322 -1 14.4442432168566 1599 2915 2440 4167 2514 1954 1055 1967 4126 1923 2397 2434 M13345 GO_REGULATION_OF_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 1517/2098 Gene Ontology BP GO:0080134 1.18411610964671e-07 4.09676049985113e-07 2260 2398.27272727273 2397 1.1841161727426e-08 1316 1.85454096217227 -1.77618879501989 -1 14.2235517474587 2256 1316 4421 2397 1338 2730 2415 2932 3011 1517 2048 2435 M12295 GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. 98/122 Gene Ontology BP GO:0032091 2.24334328203095e-07 5.22174902015509e-07 2805 2471.45454545455 2399 2.03940319162276e-08 1772 1.84601888503296 2.32433052994868 1 13.9224598385391 2802 3174 2728 2118 1932 2286 2705 2372 2898 2399 1772 2436 M14757 GO_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLATION.html The covalent attachment of a fucosyl group to an acceptor molecule. 24/29 Gene Ontology BP GO:0036065 2.17308988005443e-07 5.1420969993195e-07 4015 2676.36363636364 2399 1.97553644973214e-08 1669 2.0803676322635 -2.313521870823 -1 15.719757228715 4015 2100 1909 2399 1895 3705 2046 1669 2756 2512 4434 2437 M11834 GO_ERBB2_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB2_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. 53/61 Gene Ontology BP GO:0038128 5.41561065190762e-07 9.38154741747064e-07 1945 2576.36363636364 2400 4.92328362276101e-08 1376 1.68669809327278 -1.56446082040586 -1 12.1929283105815 1942 2878 2985 2343 2639 1865 1376 3607 2400 4019 2286 2438 M13427 GO_ENDOTHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 113/132 Gene Ontology BP GO:0003158 7.15958753375945e-07 1.14953625930237e-06 2635 2361.63636363636 2400 6.50871805795145e-08 954 2.1275109963889 2.18342987762628 1 15.1793538522577 2634 2400 954 1059 2856 2548 4627 2349 1455 1005 4091 2439 M13660 GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. 60/88 Gene Ontology BP GO:1901222 3.95926940951131e-07 7.52245020925117e-07 895 2072.90909090909 2400 3.59933647458954e-08 893 1.88187163895657 -1.76887977496503 -1 13.8340231475839 893 2472 2528 1860 2400 1289 1071 3130 2957 1628 2574 2440 M13875 GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. 76/104 Gene Ontology BP GO:0045639 2.91711768599993e-08 3.72894192114222e-07 2525 2068.09090909091 2400 2.65192520425437e-09 59 2.26872220772439 1.71919802492696 1 17.5352394883494 2525 1862 1160 2935 59 3053 2400 1551 3681 1063 2460 2441 M11052 GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. 23/43 Gene Ontology BP GO:0045939 5.04063662041538e-07 8.90097996007316e-07 3555 2331.72727272727 2401 4.58239797756877e-08 1012 2.58054173171885 -1.70950170474527 -1 18.7802435819586 3552 2596 1012 2401 2588 2438 1472 2161 1599 2018 3812 2442 M15826 GO_STEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 122/191 Gene Ontology BP GO:0016125 1.49553880240673e-07 4.36901586057683e-07 2400 2784.18181818182 2401 1.35958082188366e-08 1492 2.02657392702269 -1.92030897474962 -1 15.4840366186939 3357 2398 1985 2396 1492 3784 3394 3466 2382 2401 3571 2443 M14125 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that activates or increases the frequency, rate or extent of response to wounding. 152/245 Gene Ontology BP GO:1903036 9.56351297733215e-08 4.02645553947883e-07 2815 2120.18181818182 2402 8.69410308460273e-09 384 2.44074363257069 -2.46420930347982 -1 18.7742153346319 1837 2812 384 2402 950 3163 2526 1720 3691 1024 2813 2444 M16852 GO_ORGANELLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FUSION.html The creation of a single organelle from two or more organelles. 120/149 Gene Ontology BP GO:0048284 1.92532127069911e-07 4.90340441848e-07 1665 2562.90909090909 2402 1.75029221744805e-08 823 1.48280122187822 -1.25120916755399 -1 11.2118465066907 1661 2402 3663 3466 1746 823 1514 4127 1680 4037 3073 2445 M10293 GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of adipocyte differentiation. 114/139 Gene Ontology BP GO:0045598 8.5563074591346e-08 4.02645553947883e-07 4250 2519.90909090909 2403 7.7784616290083e-09 610 2.54052387200859 -2.16256527324034 -1 19.5459345885828 4247 2403 610 1309 823 3724 4304 4183 1059 1068 3989 2446 M10523 GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. 15/19 Gene Ontology BP GO:0048715 6.8834746008268e-07 1.11598631768805e-06 1885 2251.27272727273 2403 6.25770614051375e-08 1109 1.96041258056887 -1.72778255399803 -1 14.0095535244512 1881 3041 2705 1230 2825 2655 2317 2403 1470 3128 1109 2447 M14015 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. 17/42 Gene Ontology BP GO:0042534 9.34089671342246e-06 1.10677851814501e-05 830 2222.18181818182 2403 8.49176033983449e-07 730 2.19409113722361 -2.39597725796774 -1 13.0477657915318 830 3793 2403 2581 3900 1051 770 730 3782 3377 1227 2448 M16180 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 130/173 Gene Ontology BP GO:0090101 1.30692567317622e-07 4.19026589517727e-07 2990 2475 2403 1.18811431892279e-08 904 2.04536472603906 2.35620977157348 1 15.6734395624886 2986 3438 1892 2298 1348 2460 4237 2257 3002 2403 904 2449 M16331 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. 508/624 Gene Ontology BP GO:0045786 8.71060811220429e-08 4.02645553947883e-07 2030 2512.09090909091 2403 8.71060845364042e-09 952 1.70301531872422 1.84797998349252 1 13.0684849496656 2027 3627 4614 3468 952 1144 2403 2628 2201 3279 1290 2450 M10798 GO_ENDOCARDIAL_CUSHION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_DEVELOPMENT.html The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 45/53 Gene Ontology BP GO:0003197 1.8933639599679e-07 4.85648641490021e-07 4220 2336.18181818182 2404 1.72124011174055e-08 264 2.75419380000418 2.90168091236597 1 20.9273642232099 4154 432 264 503 2404 3533 4634 4220 861 476 4217 2451 M16590 GO_AZOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AZOLE_TRANSPORT.html The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/15 Gene Ontology BP GO:0045117 4.86909025989879e-07 8.6804126357506e-07 415 2084.81818181818 2404 4.42644667048846e-08 57 2.13992344100851 -2.13992344100851 -1 15.5842071413769 415 4086 2404 3934 4210 630 309 57 2761 2907 1220 2452 M10598 GO_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_PROTEIN_TRANSPORT.html The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. 832/1034 Gene Ontology BP GO:0006886 7.54449727207021e-08 4.02645553947883e-07 1465 2875.54545454545 2405 7.54449752820768e-09 784 1.27907502131025 -1.217711982156 -1 9.78965046416977 1461 4604 4250 4623 784 1626 1718 2405 3596 4587 1977 2453 M13815 GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. 109/135 Gene Ontology BP GO:0046434 3.74088304545765e-08 4.02645553947883e-07 2935 2539.18181818182 2405 3.40080282642517e-09 119 2.00148671669641 -2.18014566900103 -1 15.3769192234893 2932 2405 2400 3656 119 4128 4385 1434 2720 1430 2322 2454 M11573 GO_OVULATION_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE.html The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 107/155 Gene Ontology BP GO:0042698 1.80644835123542e-07 4.72213717881932e-07 3660 2307.18181818182 2406 1.64222590869567e-08 583 2.36698766612699 2.62915467397324 1 18.005633915801 3657 2406 583 1349 1698 3971 3101 2815 2795 696 2308 2455 M15341 GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of cell projection assembly. 197/259 Gene Ontology BP GO:0060491 7.73603829669456e-08 4.02645553947883e-07 4275 2441 2407 7.03276233520286e-09 574 1.84113598852788 2.1538091536876 1 14.1367363475029 4273 1672 1843 574 693 4176 3798 3109 640 2407 3666 2456 M16382 GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. 43/171 Gene Ontology BP GO:0050853 3.67590778487486e-08 4.02645553947883e-07 2410 2171.90909090909 2407 3.34173440572217e-09 115 2.50498870593165 -2.39976339451047 -1 19.2710988895666 2407 2506 1050 1992 115 3604 2971 791 3991 1327 3137 2457 M16907 GO_CORPUS_CALLOSUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORPUS_CALLOSUM_DEVELOPMENT.html The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. 24/36 Gene Ontology BP GO:0022038 7.69886181026941e-06 9.22317301832739e-06 2040 2456.27272727273 2407 6.99898977494061e-07 639 2.06366863508984 2.45355120147767 1 12.4636704567059 2036 3750 2407 1679 3859 2700 3236 1218 2307 3188 639 2458 M15444 GO_MYOTUBE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_CELL_DEVELOPMENT.html The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 24/39 Gene Ontology BP GO:0014904 2.12196370307353e-06 2.84129413248954e-06 2410 2312.63636363636 2408 1.92905977251976e-07 354 2.02437618046689 2.90191975463752 1 13.4763607933095 2408 2088 2126 2477 3445 3228 3906 354 1499 3462 446 2459 M15139 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY.html Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. 31/36 Gene Ontology BP GO:0010613 4.53867012088222e-08 4.02645553947883e-07 4565 2446.90909090909 2409 4.12606383137858e-09 185 1.73191744088459 1.01632363897814 1 13.2920194318121 4562 730 2233 1002 185 4244 3657 2409 1197 2755 3942 2460 M15985 GO_RESPONSE_TO_FOLIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. 18/23 Gene Ontology BP GO:0051593 4.01705111623183e-07 7.60738251681998e-07 4460 2681.54545454545 2409 3.65186531792579e-08 318 2.93389255466665 -3.13082347280272 -1 21.6078993877406 4459 2180 1656 1954 2409 4031 3976 1845 318 3156 3513 2461 M10786 GO_VESICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. 316/377 Gene Ontology BP GO:0016050 1.33371439239129e-07 4.20399283289481e-07 900 2238.18181818182 2410 1.21246770295052e-08 452 1.58314036268432 -1.25922413360297 -1 12.1054706951864 898 2777 3714 3750 1376 452 822 3071 2410 3787 1563 2462 M10047 GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. 9/18 Gene Ontology BP GO:0036150 8.77131037013773e-07 1.34785030225399e-06 405 1941.72727272727 2411 8.7713138322545e-08 84 2.65475828737425 -2.65475828737425 -1 18.7447529154182 403 3093 4219 2411 3828 498 131 84 3745 2445 502 2463 M12603 GO_RESPONSE_TO_PROSTAGLANDIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 49/107 Gene Ontology BP GO:0034694 1.0050188062156e-07 4.02645553947883e-07 3905 2588.81818181818 2413 9.1365350193414e-09 1012 2.41614219867939 -2.21868377493519 -1 18.5839431894089 3904 1919 1088 2714 1012 3230 1851 4594 2413 1701 4051 2464 M12254 GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 22/26 Gene Ontology BP GO:0050860 4.05460278831194e-07 7.65979162566603e-07 1905 2347 2414 3.68600321415994e-08 673 2.13755354831731 -2.40457874361792 -1 15.7072684001318 1903 3271 2185 1784 2414 3054 2780 1789 673 2962 3002 2465 M14160 GO_AMELOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMELOGENESIS.html The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. 15/23 Gene Ontology BP GO:0097186 6.68385411472089e-07 1.09365837157341e-06 2990 2144.45454545455 2414 6.07623285941258e-08 338 2.499099090217 1.86734405322912 1 17.9139488415067 2988 3029 1921 1057 2798 2503 964 3345 338 2232 2414 2466 M16583 GO_HEMOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOSTASIS.html The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. 303/448 Gene Ontology BP GO:0007599 1.84501592270644e-07 4.77959302622087e-07 4610 2686.09090909091 2414 1.67728734312503e-08 679 2.07856724547195 2.34933995730879 1 15.7858759134988 4608 2346 679 2209 1713 4089 2910 3604 2414 1274 3701 2467 M11214 GO_RESPONSE_TO_POTASSIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_POTASSIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. 10/20 Gene Ontology BP GO:0035864 5.97881015401988e-07 1.01271946292881e-06 2385 2185.27272727273 2416 5.43528343531495e-08 335 3.82182183326874 -3.23116041933198 -1 27.6042777651703 2381 3852 1548 2416 2705 2677 1563 527 3350 2684 335 2468 M15447 GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 99/136 Gene Ontology BP GO:0072329 2.01045717045867e-07 4.96268287222503e-07 2420 2427.09090909091 2416 1.82768850380286e-08 1347 1.66182123276838 -1.53568275991533 -1 12.5674048865874 1347 2416 3174 2928 1808 1930 2496 1919 2416 3564 2700 2469 M11855 GO_REGULATION_OF_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENERGY_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of energy homeostasis. 22/44 Gene Ontology BP GO:2000505 2.10051280216233e-06 2.81587759737021e-06 3300 2597.18181818182 2419 1.90955891608142e-07 1625 1.75025027862016 -1.30629662783976 -1 11.6458113401616 3297 2109 2159 2036 3440 2679 1625 2604 2419 1842 4359 2470 M11666 GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS.html The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 32/36 Gene Ontology BP GO:0003203 4.46301679072685e-07 8.20807001077156e-07 4365 2224.81818181818 2420 4.05728881464939e-08 178 2.7058673081529 -2.43137934654248 -1 19.8124980583315 4365 669 542 178 2480 4317 3142 4166 1417 777 2420 2471 M10086 GO_MEIOTIC_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. 42/69 Gene Ontology BP GO:0045132 1.39706041895346e-06 1.96747037814481e-06 35 1671.45454545455 2422 1.2700557328418e-07 11 1.620390362454 1.67868392005278 1 11.0792463160553 33 3215 3087 2422 3274 29 11 469 2713 2812 321 2472 M16324 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. 31/51 Gene Ontology BP GO:0019883 3.86534791191423e-06 4.89425911672987e-06 340 2126 2423 3.51395882114155e-07 338 1.35121516818781 -1.09575052499577 -1 8.57492229423266 338 696 2809 2460 3648 1333 1686 2423 3520 2435 2038 2473 M16849 GO_RESPONSE_TO_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. 94/150 Gene Ontology BP GO:0014823 6.70490898196468e-08 4.02645553947883e-07 3450 2272.54545454545 2424 6.09537198755385e-09 226 2.43063365135757 2.22215273923706 1 18.6960228267446 3449 2424 990 226 516 3067 3627 4440 1638 1558 3063 2474 M10099 GO_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMORY.html The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). 103/156 Gene Ontology BP GO:0007613 1.00444476372869e-07 4.02645553947883e-07 2760 2150.72727272727 2425 9.13131645080187e-09 649 2.39279799378791 2.88470628835739 1 18.4033946911851 2757 3168 1034 3175 1008 2426 3794 649 2425 1361 1861 2475 M11726 GO_PEPTIDYL_ARGININE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_MODIFICATION.html The modification of peptidyl-arginine. 15/19 Gene Ontology BP GO:0018195 2.50482558087485e-06 3.2886437437389e-06 2245 2315.81818181818 2425 2.27711675706027e-07 635 1.79652477788203 1.56818349650724 1 11.8099871286441 2244 2213 2852 2425 3512 1620 635 2678 1145 3130 3020 2476 M14130 GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of anion transmembrane transport. 32/44 Gene Ontology BP GO:1903959 2.58277837211295e-07 5.67674433889539e-07 3935 2588.36363636364 2425 2.34798061393512e-08 940 2.23433963722738 -2.69531612973723 -1 16.7747425735336 3934 2558 2425 1173 2057 4497 3746 940 1506 3410 2226 2477 M15783 GO_RESPONSE_TO_CYTOKINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CYTOKINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 706/1023 Gene Ontology BP GO:0034097 2.30096821438842e-07 5.31863144637323e-07 1475 2645.90909090909 2425 2.30096845263891e-08 836 2.0082589970148 -1.91870516882784 -1 15.1357133336368 1472 3874 4571 3755 2028 1902 1594 3003 3645 836 2425 2478 M16539 GO_UTERUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTERUS_DEVELOPMENT.html The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. 16/24 Gene Ontology BP GO:0060065 2.84919138336415e-06 3.70005233234535e-06 1925 2127 2425 2.59017733938322e-07 374 1.98533517590174 -1.59508939029437 -1 12.9390960491912 1922 3026 2561 3007 3555 1439 836 374 3424 2425 828 2479 M10643 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. 18/31 Gene Ontology BP GO:2001014 6.7520037297629e-07 1.09965255003804e-06 3135 2569.81818181818 2428 6.13818709274205e-08 984 2.43904397589276 -1.73553772868893 -1 17.4739876798404 3134 3310 2046 3209 2812 2428 2235 4296 984 2330 1484 2480 M16589 GO_ZYMOGEN_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_ACTIVATION.html The proteolytic processing of an inactive enzyme to an active form. 132/192 Gene Ontology BP GO:0031638 1.24199231806239e-07 4.14338946095474e-07 3000 2541.45454545455 2428 1.12908398925279e-08 643 2.47988498021109 2.5235123417712 1 19.0396537421584 2996 2395 643 2218 1282 3651 4245 4160 2428 1322 2616 2481 M12867 GO_OVULATION_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE_PROCESS.html A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 86/121 Gene Ontology BP GO:0022602 1.92887173272823e-07 4.90549772233375e-07 4000 2392.90909090909 2429 1.75351991076726e-08 640 2.33108984515131 2.62545382676311 1 17.6843559306863 3996 2429 640 1767 1747 4480 3758 1038 2759 762 2946 2482 M12990 GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 231/352 Gene Ontology BP GO:0070372 9.13316711586654e-08 4.02645553947883e-07 3895 2451.90909090909 2429 8.30287954093135e-09 420 2.09067919087472 2.09849121217438 1 16.0667506973229 3891 1630 541 988 898 2429 4614 4007 3313 420 4240 2483 M16248 GO_NEGATIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_KILLING.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. 36/80 Gene Ontology BP GO:0031342 1.41266373294682e-06 1.9864383044429e-06 1030 2286.45454545455 2429 1.284240581861e-07 599 1.65874001238434 -1.35763784185351 -1 11.3355355778195 1027 599 2026 2895 3278 1869 2897 1626 4065 2429 2440 2484 M13776 GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT.html The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. 37/41 Gene Ontology BP GO:0043001 2.90836062824479e-08 3.72894192114222e-07 2435 2045.36363636364 2431 2.643964242448e-09 56 1.61324972785105 -1.81363604814507 -1 12.4392639311583 2431 2898 3133 1594 56 2759 3275 597 427 3323 2006 2485 M16571 GO_COFACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. 163/181 Gene Ontology BP GO:0051188 6.88057821823079e-08 4.02645553947883e-07 720 2761.09090909091 2431 6.25507130311211e-09 547 1.35603406685887 -1.44073060151436 -1 10.384866285961 718 3889 3996 4494 547 2306 2431 2012 3415 4175 2389 2486 M10128 GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. 88/111 Gene Ontology BP GO:0043407 1.20145146538772e-07 4.11313958327346e-07 3825 2544 2432 1.0922286645461e-08 161 1.81834706800207 -1.42370779329577 -1 13.9401396230569 3821 161 2331 2069 1242 4377 3556 2881 1254 2432 3860 2487 M13355 GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 47/57 Gene Ontology BP GO:0090199 4.18199861221442e-07 7.84947137661706e-07 2670 2349.81818181818 2432 3.80181764288572e-08 763 2.03227897268685 2.30414116902488 1 14.9025036156968 2666 3698 2678 2341 2432 1384 948 1578 763 4050 3310 2488 M14715 GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. 11/44 Gene Ontology BP GO:0002710 6.74652408283688e-07 1.09914483744538e-06 2145 2163.90909090909 2433 6.13320559248008e-08 56 2.19264426106216 -2.67396309621362 -1 15.6988424976877 2142 1204 1969 2433 2810 3198 2876 259 3952 2904 56 2489 M16164 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. 31/60 Gene Ontology BP GO:0002717 1.98503006680888e-06 2.68108705395116e-06 350 2105.18181818182 2434 1.80457441625161e-07 349 1.3192470414214 -1.01214981311881 -1 8.78663795468858 349 2004 2899 2520 3413 563 477 3104 3880 2434 1514 2490 M16835 GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that modulates the frequency, rate or extent of execution phase of apoptosis. 30/35 Gene Ontology BP GO:1900117 1.02045821134758e-06 1.51111922298151e-06 4100 2458.72727272727 2434 9.27689713347234e-08 228 2.48424491489201 2.69644538390225 1 17.3849852496716 4098 2926 1972 1788 3101 3735 2065 2086 228 2613 2434 2491 M12396 GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. 86/132 Gene Ontology BP GO:0040014 4.21770887358036e-07 7.89738405986697e-07 3750 2389.54545454545 2437 3.83428152924962e-08 194 1.95082715122001 1.90575288474232 1 14.2948635573952 3749 194 2198 1603 2437 4084 3828 1108 933 3658 2493 2492 M10467 GO_MYELOID_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 106/127 Gene Ontology BP GO:0002262 2.18606253680211e-07 5.15590364235942e-07 1370 2574.27272727273 2438 1.98732977638498e-08 768 1.40562200524393 -1.41074666226157 -1 10.585844358528 1370 3903 3677 4214 1903 1351 768 1112 3669 3912 2438 2493 M14112 GO_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. 10/25 Gene Ontology BP GO:0019433 2.7241517790957e-05 3.04845556232137e-05 3160 2747.81818181818 2438 2.47653228319264e-06 1619 2.14896121483294 -2.29085052240161 -1 11.6336837100556 3160 2280 1690 1990 4134 3359 2438 3765 3666 1619 2125 2494 M14603 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE.html The directed movement of a protein to a specific location in a vacuole. 42/44 Gene Ontology BP GO:0072666 4.24372323986535e-07 7.94105671136421e-07 465 2314.45454545455 2438 3.85793096224088e-08 113 1.01508674602571 -1.00036783035537 -1 7.38581520461041 463 4192 3953 4054 2438 113 130 853 4392 4430 441 2495 M15157 GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that activates or increases the frequency, rate, or extent of peptide secretion. 81/128 Gene Ontology BP GO:0002793 9.17866428726743e-08 4.02645553947883e-07 4320 2594.81818181818 2439 8.34424060928395e-09 905 2.33645000846107 -2.20245050201057 -1 17.9675887095294 4320 2435 982 1501 905 4532 3402 2439 2833 1233 3961 2496 M12035 GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. 26/36 Gene Ontology BP GO:0060706 6.73154210715223e-08 4.02645553947883e-07 4615 2354.45454545455 2440 6.11958392102129e-09 521 2.28701727939707 2.09192342426617 1 17.5852666284347 4615 2962 2015 1132 521 3393 2737 4249 1152 2440 683 2497 M13723 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. 27/32 Gene Ontology BP GO:1902307 2.36033482156049e-07 5.40178690738178e-07 3355 2641.72727272727 2440 2.14575915890546e-08 1969 1.85423326712949 -1.62660406584035 -1 13.9518569622041 3355 2041 2309 2263 1969 2864 2252 2440 3432 2556 3578 2498 M16885 GO_LACTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATION.html The secretion of milk by the mammary gland. 50/88 Gene Ontology BP GO:0007595 1.19378795945769e-07 4.10546590935448e-07 4245 2387.81818181818 2441 1.08526184021483e-08 481 2.076447920557 1.73980295994111 1 15.9354895539981 4244 481 1535 1171 1234 4287 4439 2441 652 2538 3244 2499 M10313 GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. 49/55 Gene Ontology BP GO:0031122 1.09165923189297e-07 4.02645553947883e-07 2445 2295.27272727273 2442 9.92417532783694e-09 884 1.3021983080555 -0.961125760874729 -1 9.96849033964478 2442 1920 3559 2584 1135 2241 884 2543 2835 2957 2148 2500 M10649 GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. 77/130 Gene Ontology BP GO:2000106 2.40207118366385e-07 5.47079648437978e-07 3575 2413.63636363636 2443 2.1837013144856e-08 941 2.43659838714302 -2.45664807633778 -1 18.349852580882 3574 2443 941 1398 1980 3631 2469 3799 1605 1267 3443 2501 M12094 GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 37/59 Gene Ontology BP GO:0051281 1.3373133179156e-06 1.896068090356e-06 2445 2442.81818181818 2443 1.21574011893502e-07 1794 2.14846566117913 2.15570588483294 1 14.7651727761005 2443 1973 1794 2673 3249 2000 2835 3210 2189 1979 2526 2502 M13728 GO_FEMALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_SEX_DIFFERENTIATION.html The establishment of the sex of a female organism by physical differentiation. 120/166 Gene Ontology BP GO:0046660 3.85721653115147e-07 7.39803319020932e-07 3660 2567.81818181818 2443 3.50656109766345e-08 702 2.25060427692138 2.47367608535542 1 16.5845402993465 3656 1821 702 785 2377 2981 4193 3935 2443 912 4441 2503 M10215 GO_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 868/1225 Gene Ontology BP GO:1901698 5.45931729137679e-08 4.02645553947883e-07 3270 2295.90909090909 2444 5.45931742549543e-09 270 2.03295993404726 -1.85340428229972 -1 15.6203390423859 3267 1373 4232 520 406 2918 2444 3875 2347 270 3603 2504 M12806 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. 26/43 Gene Ontology BP GO:0051769 1.23328955105157e-06 1.76895693003791e-06 2135 2564.63636363636 2444 1.12117294765197e-07 810 1.94140160252937 -2.02363314702607 -1 13.4029760505966 2132 3526 2360 3289 3203 1706 810 1651 3972 3118 2444 2505 M10415 GO_SKELETAL_MUSCLE_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_TISSUE_REGENERATION.html The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. 30/42 Gene Ontology BP GO:0043403 9.86452972803074e-08 4.02645553947883e-07 2450 2232.63636363636 2445 8.9677547003129e-09 987 1.87797007719928 2.0208917295452 1 14.4216181596692 2446 2561 2445 2924 987 1505 1875 2414 2546 2000 2856 2506 M14250 GO_DNA_REPLICATION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_CHECKPOINT.html A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. 13/15 Gene Ontology BP GO:0000076 6.52070830312445e-05 7.0642271791474e-05 1885 2389.27272727273 2445 5.92809234747358e-06 658 1.9858109833913 1.9858109833913 1 9.86607183115744 1046 3821 3106 2531 4265 1433 658 1881 1882 3214 2445 2507 M15395 GO_KETONE_BODY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BODY_METABOLIC_PROCESS.html The chemical reactions and pathways involving ketone body. 9/14 Gene Ontology BP GO:1902224 3.90491815777153e-07 7.47104612997982e-07 2140 2434.72727272727 2446 3.90491884394906e-08 424 2.14256484097762 1.6917338947935 1 15.7724111611222 2138 1246 4551 3145 2446 1442 424 4350 2602 1907 2531 2508 M16598 GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 29/39 Gene Ontology BP GO:0010922 3.17223670144892e-08 3.85278716745714e-07 2220 2392 2446 2.88385158835475e-09 76 1.87688689156998 2.13866481017717 1 14.4567044293679 2216 2048 2322 3204 76 2469 2446 2936 3721 2851 2023 2509 M14440 GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion. 12/14 Gene Ontology BP GO:0006851 4.84007616973172e-08 4.02645553947883e-07 3185 2469.54545454545 2447 4.40006934201372e-09 149 1.86351911846829 1.35728241189558 1 14.3098517101841 3185 1178 2447 2443 225 2565 2382 4569 149 3503 4519 2510 M13634 GO_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_SORTING_PATHWAY.html A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. 12/12 Gene Ontology BP GO:0071985 6.19380068472688e-06 7.54443837330737e-06 960 2095.54545454545 2448 5.63074374781705e-07 220 1.41264775115849 -1.10379274031813 -1 8.64837297261969 960 2707 3027 2448 3792 1074 910 3333 220 3500 1080 2511 M10640 GO_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 440/596 Gene Ontology BP GO:1901652 4.67506853232361e-08 4.02645553947883e-07 2950 1862.81818181818 2449 4.25006239242753e-09 197 2.00819816256816 -1.80046656662074 -1 15.4288268159169 2946 1487 602 571 197 2640 2449 3243 2686 681 2989 2512 M11464 GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. 9/20 Gene Ontology BP GO:0007216 1.55731641032544e-05 1.79050982388047e-05 2390 2702.45454545455 2449 1.55732732398789e-06 646 2.47233298066201 2.03198672350225 1 14.0907981885659 3629 1245 4304 2389 4044 3799 2388 2718 646 2449 2116 2513 M11515 GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein oligomerization. 20/25 Gene Ontology BP GO:0032461 8.37496596677282e-07 1.3006914767488e-06 2505 2541 2450 7.61360832268984e-08 1374 3.61099784159715 -3.61982461799857 -1 25.6012152287398 2503 3551 1374 2450 2952 1971 1897 4642 1420 3056 2135 2514 M11093 GO_OOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOGENESIS.html The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. 63/107 Gene Ontology BP GO:0048477 4.32305052594797e-07 8.03817365109898e-07 3030 2288.36363636364 2452 3.93004670494324e-08 763 2.10191194524292 2.21881567174248 1 15.3904168798253 3026 1884 1277 763 2452 3072 3721 2534 1674 1665 3104 2515 M14167 GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 12/18 Gene Ontology BP GO:0060391 8.29653591188743e-06 9.89586813586573e-06 2195 2466.36363636364 2452 7.54233381777846e-07 744 1.57582293656713 1.74232444662303 1 9.43468649597898 2193 3365 2897 2113 3875 1504 744 3321 2452 3502 1164 2516 M12130 GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS.html Any process that modulates the frequency, rate or extent of removal of superoxide radicals. 9/10 Gene Ontology BP GO:2000121 2.95242865637447e-05 3.2936107739416e-05 2845 2505.54545454545 2453 2.95246788286532e-06 836 2.75718663150528 2.60712723420608 1 14.8435172231814 2844 1253 4346 2063 4156 2443 1557 2889 836 2453 2721 2517 M13423 GO_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. 1529/2245 Gene Ontology BP GO:0045595 8.19788795447037e-26 2.38404829075941e-23 3310 2290.63636363636 2453 8.19788795447041e-27 9 2.18255547796899 2.35638484313503 1 59.6113564153309 3306 1303 4428 295 549 2961 4623 2453 1924 9 3346 2518 M14221 GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is decreased. 24/46 Gene Ontology BP GO:0045776 1.65699177723271e-07 4.52287618430271e-07 2970 2644.54545454545 2454 1.5063562745761e-08 1188 2.2308317070658 2.16128656906196 1 17.014491849433 2969 2101 1413 4465 1617 2887 3708 2454 3988 1188 2300 2519 M16272 GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. 23/30 Gene Ontology BP GO:0032332 4.32399498145299e-07 8.03817365109898e-07 2190 2413.45454545455 2454 3.93090530119436e-08 824 1.8437840420267 -1.57369387191318 -1 13.4877337875517 2188 3277 2535 2713 2454 1312 824 2228 2340 2737 3940 2520 M11681 GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 412/516 Gene Ontology BP GO:0090407 6.88893925943261e-08 4.02645553947883e-07 1845 2526.81818181818 2455 6.26267225013494e-09 550 1.5326423637162 -1.55946543173133 -1 11.750788274724 1844 2339 3748 3368 550 2506 3077 2455 2198 3352 2358 2521 M16273 GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 78/95 Gene Ontology BP GO:0014068 2.65484148801175e-07 5.75092059763439e-07 4050 2235.54545454545 2456 2.41349255307616e-08 225 2.54014042693661 2.58665655184523 1 19.0673728698596 4047 225 533 587 2087 3646 2659 3707 2456 917 3727 2522 M14681 GO_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMETE_GENERATION.html The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. 529/1037 Gene Ontology BP GO:0007276 1.55847231208508e-07 4.41300019561337e-07 2180 2800.27272727273 2457 1.55847242138271e-08 1654 1.83010154967326 1.93934682043016 1 13.9632793429507 2178 4114 4511 4110 1654 1815 2457 2738 2871 2272 2083 2523 M13017 GO_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 66/99 Gene Ontology BP GO:0043550 5.60027086144293e-08 4.02645553947883e-07 3285 2305.63636363636 2458 5.09115545818379e-09 346 1.90211676675564 -1.91158876399711 -1 14.6083732261512 3281 2458 1910 1229 346 3422 2698 3471 1531 1703 3313 2524 M10302 GO_MAMMARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_MORPHOGENESIS.html The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 65/77 Gene Ontology BP GO:0060443 6.53791211612768e-07 1.08207080423379e-06 3040 2171.63636363636 2459 5.94355823550088e-08 658 2.58442566225644 2.89131977140606 1 18.543557893835 3036 2459 913 658 2767 1424 2740 4555 856 1638 2842 2525 M15803 GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. 9/33 Gene Ontology BP GO:0002825 8.02096221270203e-07 1.26001138337956e-06 1525 2398.54545454545 2461 8.02096510781606e-08 375 2.56674125945955 -2.85439083095061 -1 18.2107191067959 1522 2287 4574 2919 2988 2526 2739 375 1797 2461 2196 2526 M15949 GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN.html The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. 9/16 Gene Ontology BP GO:0002016 7.37810661448759e-08 4.02645553947883e-07 2505 2621.90909090909 2462 7.37810685945165e-09 756 2.09957933411481 -2.7548391373812 -1 16.1355860893803 2501 2283 4582 3194 756 3436 2243 1500 3746 2462 2138 2527 M10194 GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-beta production. 62/97 Gene Ontology BP GO:0032648 1.08767921516677e-06 1.59100012202797e-06 2005 2667.45454545455 2463 9.88799775377598e-08 990 1.69822722513133 -1.5116912020976 -1 11.805834519762 2003 3470 3073 4177 3147 2463 1950 990 2256 3637 2176 2528 M12237 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. 64/95 Gene Ontology BP GO:0032024 4.588567918472e-08 4.02645553947883e-07 3445 2427.63636363636 2463 4.17142546743304e-09 189 2.11270815940077 2.48837900838669 1 16.2371269086048 3444 2463 1605 1124 189 3803 4206 4307 831 1741 2991 2529 M16007 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. 16/23 Gene Ontology BP GO:1903427 4.36893776065974e-07 8.09907067743019e-07 2465 2567.18181818182 2464 3.9717623893445e-08 1167 1.95084710479068 -1.71656695191302 -1 14.2691713934781 3813 2196 2461 1833 2464 4210 2492 1587 1167 2872 3144 2530 M16011 GO_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). 222/281 Gene Ontology BP GO:0046777 7.82356365273497e-08 4.02645553947883e-07 4030 2861.90909090909 2464 7.11233084632168e-09 699 1.89835198584208 1.86888191713116 1 14.579255698129 4028 2364 2236 1655 699 4067 4532 3491 1396 2464 4549 2531 M16194 GO_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TISSUE_REMODELING.html Any process that modulates the frequency, rate, or extent of tissue remodeling. 63/85 Gene Ontology BP GO:0034103 7.14389253533172e-08 4.02645553947883e-07 3370 2125.36363636364 2464 6.49444797028174e-09 276 3.05080704492038 2.69335754926823 1 23.4925612124672 3369 2464 276 1071 591 4484 3226 1404 3035 459 3000 2532 M10072 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY.html Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 120/138 Gene Ontology BP GO:0090175 4.37745067214497e-07 8.11162006272025e-07 905 2471.18181818182 2465 3.97950140286236e-08 904 1.39471016304169 1.6314014035177 1 10.1709083363666 904 3658 3893 2821 2465 1368 1087 1770 3077 4036 2104 2533 M10339 GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 294/477 Gene Ontology BP GO:0045861 1.56669291306229e-07 4.41807401483567e-07 2465 2231 2465 1.42426638602882e-08 593 2.19623875238356 2.31546239506882 1 16.7760997000103 2465 1579 593 2838 1562 2042 3160 2509 3394 1471 2928 2534 M12116 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that modulates the activity of the enzyme nitric-oxide synthase. 57/73 Gene Ontology BP GO:0050999 1.14047466801174e-07 4.06950048332718e-07 4120 2447.54545454545 2467 1.03679520648516e-08 402 1.91045964463831 1.91223326793837 1 14.6622282573031 4118 402 2280 1227 1186 3986 2707 2352 3479 2467 2719 2535 M10756 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. 87/124 Gene Ontology BP GO:0051149 1.17351273521018e-07 4.08625383150012e-07 3825 2624.09090909091 2468 1.06682981618827e-08 993 2.1184648081215 2.04408139186189 1 16.265246465465 3824 1848 1435 2677 1218 3601 4429 2468 993 1789 4583 2536 M13153 GO_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 31/40 Gene Ontology BP GO:0010939 4.39733346062495e-07 8.13003638007822e-07 2035 2496.63636363636 2468 3.99757667232628e-08 1644 1.79596144533777 -1.80016864536673 -1 13.1245100919892 2035 2566 2668 3717 2468 1974 1644 3199 2321 2752 2119 2537 M15399 GO_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MIGRATION.html The movement of a lymphocyte within or between different tissues and organs of the body. 33/74 Gene Ontology BP GO:0072676 8.74433718280576e-07 1.34574395276902e-06 2510 2145.72727272727 2470 7.94940059856208e-08 428 2.68067786750275 -3.14228910637208 -1 18.9309735024265 2508 2541 1152 2470 2980 2269 1811 428 3722 1017 2705 2538 M10096 GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION.html The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle. 12/18 Gene Ontology BP GO:0002031 6.98568369221514e-06 8.420825445564e-06 2025 2429.90909090909 2471 6.350641703664e-07 975 1.57555996233128 1.85171364451327 1 9.5666673999422 2023 3366 2816 2471 3833 1072 975 2134 3284 3075 1680 2539 M10317 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 41/52 Gene Ontology BP GO:0050732 8.44070327518529e-08 4.02645553947883e-07 2475 2050.18181818182 2471 7.67336690820760e-09 591 1.81815805632733 -1.4299809033332 -1 13.9590206715832 2471 591 2770 814 796 3076 3795 3022 835 2700 1682 2540 M15017 GO_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location. 1841/2309 Gene Ontology BP GO:0008104 6.50862908837805e-08 4.02645553947883e-07 2475 2844.45454545455 2472 6.50862927900819e-09 597 1.63980150033805 -1.43107021627275 -1 12.5795773158578 2472 3105 4530 4138 597 2073 2295 3035 2225 4440 2379 2541 M10522 GO_RESPONSE_TO_MUSCLE_STRETCH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_STRETCH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. 27/33 Gene Ontology BP GO:0035994 3.84434889394724e-08 4.02645553947883e-07 3310 2321.90909090909 2473 3.49486269193146e-09 129 2.17351454762091 -1.841771079046 -1 16.7074150219331 3309 774 1365 2699 129 2746 2028 3507 2473 1933 4578 2542 M10890 GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. 60/70 Gene Ontology BP GO:0045600 8.41345980489631e-08 4.02645553947883e-07 795 2382.18181818182 2473 7.64860011513839e-09 792 2.58788720579722 2.61368103024837 1 19.9122515750111 3194 2473 1005 1778 793 3206 3815 2728 792 1805 4615 2543 M12214 GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. 15/23 Gene Ontology BP GO:0034104 7.14285731142358e-08 4.02645553947883e-07 4520 2775.18181818182 2473 6.49350685757686e-09 590 2.50371589510383 2.26399054542578 1 19.261254729761 4518 1093 1537 2473 590 4463 4174 2993 2231 2230 4225 2544 M12193 GO_SEXUAL_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEXUAL_REPRODUCTION.html A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. 623/1219 Gene Ontology BP GO:0019953 1.64713407496314e-07 4.51893564316244e-07 2390 2681.81818181818 2474 1.64713419705043e-08 1668 1.93124494698874 2.01353559159384 1 14.7166094511529 2390 3114 4353 3657 1702 1936 2623 3164 2474 1668 2419 2545 M16560 GO_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_AGGREGATION.html The adhesion of one platelet to one or more other platelets via adhesion molecules. 56/83 Gene Ontology BP GO:0070527 1.50653108043617e-07 4.37329540718478e-07 2610 2348.72727272727 2474 1.36957380327404e-08 1127 2.09915563919468 2.58088489433832 1 16.0412051273397 2606 2474 1328 2662 1506 2999 4328 2325 1127 2860 1621 2546 M12231 GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that modulates the frequency, rate, or extent of immunoglobulin production. 55/86 Gene Ontology BP GO:0002637 1.65649785539333e-06 2.28511251738664e-06 240 2264.81818181818 2477 1.50590827514601e-07 237 1.4166057248564 -1.37446923846558 -1 9.5615828402564 237 2477 3312 3912 3342 1266 1435 1083 3791 2519 1539 2547 M14471 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 49/81 Gene Ontology BP GO:0090280 7.20137741533689e-07 1.15379683847004e-06 2480 2276.63636363636 2477 6.54670888418479e-08 465 2.36140786210163 2.21449059970239 1 16.854890574992 2477 465 1063 2202 2861 2010 2846 3754 2943 1094 3328 2548 M11330 GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. 18/25 Gene Ontology BP GO:1902931 3.68412830068387e-07 7.1545279562112e-07 1805 2353 2478 3.34920810693593e-08 519 2.17591413361607 -1.41135739610697 -1 16.0689874671461 1803 2662 1705 2478 2340 1474 519 4178 2831 2758 3135 2549 M11116 GO_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_PROLIFERATION.html The expansion of a T cell population by cell division. Follows T cell activation. 40/59 Gene Ontology BP GO:0042098 4.66943915320483e-08 4.02645553947883e-07 2835 1956.72727272727 2479 4.24494477482943e-09 195 1.79417963805633 -1.85506421089849 -1 13.7735670470653 2835 564 2514 975 195 2479 1154 4182 760 2563 3303 2550 M11248 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD.html The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). 34/61 Gene Ontology BP GO:0043153 2.73341781573314e-08 3.62759496859141e-07 4225 2484.81818181818 2479 2.4849253179044e-09 46 2.09781500849332 2.49090465866485 1 16.2368811693791 4222 677 2000 2437 46 4050 4195 4228 254 2479 2745 2551 M10335 GO_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMMONIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. 53/89 Gene Ontology BP GO:0060359 9.09286765785215e-07 1.38991830525578e-06 3915 2406.72727272727 2480 8.26624674186106e-08 437 2.02659098831978 -2.00085372306701 -1 14.2523046291743 3912 437 1939 1575 3006 4180 3234 2686 1383 1642 2480 2552 M13598 GO_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INTERNALIZATION.html A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. 51/81 Gene Ontology BP GO:0031623 3.75578410742415e-07 7.2422973277433e-07 2480 2626.27272727273 2480 3.41434977145657e-08 1926 1.7619338787116 2.0044733992844 1 12.980897522178 2480 2488 2398 3441 2363 2181 3175 2159 3179 1926 3099 2553 M14795 GO_PHOSPHOLIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORT.html The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. 50/68 Gene Ontology BP GO:0015914 2.26102447976236e-06 3.00387968696289e-06 2395 2446.27272727273 2481 2.05547891227944e-07 408 2.19617897018205 -1.96799958932658 -1 14.5646101236634 2394 1916 2414 2667 3471 2481 1805 3412 408 2537 3404 2554 M10536 GO_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CHEMOTAXIS.html The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). 146/236 Gene Ontology BP GO:0060326 8.4289663850295e-10 1.76666579232172e-08 2935 2204.54545454545 2482 7.66269671659901e-11 153 2.56740105553001 -2.57341912540218 -1 23.9696899085186 2931 1771 153 1755 1415 2856 2482 3805 3294 319 3469 2555 M12759 GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of female gonad development. 6/17 Gene Ontology BP GO:2000194 7.60154678269662e-05 8.20078766053498e-05 2230 2796.63636363636 2482 7.60180682102647e-06 969 2.29676426602046 -2.29941118174146 -1 11.2471280381276 2230 3103 4387 2482 4296 2184 1964 2345 3867 2936 969 2556 M12723 GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 215/303 Gene Ontology BP GO:0050730 8.97589409006636e-08 4.02645553947883e-07 3765 2445.90909090909 2483 8.15990405116229e-09 236 2.13531701503793 2.27475002778002 1 16.4119880765403 3762 1645 550 236 874 3602 4450 4385 2483 561 4357 2557 M14904 GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION.html A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. 608/995 Gene Ontology BP GO:0003006 8.2846917979451e-08 4.02645553947883e-07 3165 2654.63636363636 2484 8.28469210680764e-09 706 1.98999956503359 1.98199531993134 1 15.288075418732 3165 1421 4523 1941 896 2484 3193 4333 2276 706 4263 2558 M15110 GO_CATECHOLAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_TRANSPORT.html The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 9/17 Gene Ontology BP GO:0051937 3.7608900418557e-06 4.77473979938733e-06 3300 2099.72727272727 2484 3.76089640680311e-07 169 3.22501283685647 -2.85862791519086 -1 20.6508514610317 3298 2738 4535 169 3668 3392 2484 240 189 1906 478 2559 M15497 GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. 52/80 Gene Ontology BP GO:0042149 5.39566314085837e-08 4.02645553947883e-07 2730 2404.81818181818 2487 4.90514843017365e-09 311 2.04777645810386 -1.79373221582097 -1 15.7349328432778 2728 2487 1937 2762 311 2364 1915 4237 3318 3179 1215 2560 M14020 GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 154/231 Gene Ontology BP GO:0072330 5.3383545312075e-08 4.02645553947883e-07 3110 2294.18181818182 2488 4.85304969158545e-09 297 2.19958191549496 -2.10519688480952 -1 16.909024977988 3110 1747 540 2171 297 3065 2488 4322 2803 780 3913 2561 M14669 GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. 294/456 Gene Ontology BP GO:0048871 3.20485604865474e-12 1.05015459115426e-10 3955 2392.81818181818 2489 2.91350549878127e-13 92 2.35319589828657 2.51370743295567 1 28.2960452263025 3951 1562 92 838 469 3561 4207 4633 2489 342 4177 2562 M14331 GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 61/118 Gene Ontology BP GO:0030816 1.00537504890665e-07 4.02645553947883e-07 2975 2533.72727272727 2490 9.13977358955598e-09 1013 2.18961090685212 2.43275123005806 1 16.831907310258 2971 2469 1633 2912 1013 2490 4075 2816 3068 1942 2482 2563 M15093 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. 14/16 Gene Ontology BP GO:0010667 8.59383704456613e-07 1.32803466517324e-06 3365 2621.27272727273 2494 7.81258218324505e-08 1581 2.01292152668747 -1.69361328044641 -1 14.2036301704792 3365 2214 2098 2953 2970 3447 2069 3671 1972 2494 1581 2564 M15161 GO_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORT.html The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 46/72 Gene Ontology BP GO:0015918 2.21283024532382e-07 5.1753788816965e-07 3825 2641.81818181818 2494 2.0116640617249e-08 940 2.8422189746818 3.24616222196468 1 21.5045619087311 3823 2494 940 1105 1919 3914 4530 3347 942 1650 4396 2565 M11560 GO_SULFATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATION.html The addition of a sulfate group to a molecule. 9/26 Gene Ontology BP GO:0051923 6.66491636348106e-06 8.06130903022547e-06 4520 2504.45454545455 2495 6.664936353065e-07 429 2.09618474443079 -1.25703832486821 -1 12.8099166275367 4516 2289 4311 2204 3844 3380 585 472 429 3024 2495 2566 M11652 GO_BONE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_GROWTH.html The increase in size or mass of a bone that contributes to the shaping of that bone. 21/26 Gene Ontology BP GO:0098868 3.0625668537981e-06 3.95068576953772e-06 1415 2330.09090909091 2496 2.78415556102885e-07 1414 2.45351434565338 2.53417682631514 1 15.9301939721937 1465 2623 1765 2523 3582 1414 1907 1415 3608 2833 2496 2567 M12232 GO_FATTY_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. 50/61 Gene Ontology BP GO:0035337 3.74016160963657e-06 4.74971942402811e-06 430 2201.09090909091 2497 3.40015269836472e-07 430 1.47393894484018 -1.42213583719364 -1 9.38629594963338 430 2497 3048 4122 3639 722 463 1296 2631 3429 1935 2568 M12368 GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. 48/79 Gene Ontology BP GO:1903018 9.80607960205733e-07 1.46949076935178e-06 1290 2400.09090909091 2498 8.91462179357514e-08 621 1.44848805288393 -1.28503862071473 -1 10.1149852989606 1287 2498 3495 3948 3067 1159 621 2097 3551 3706 972 2569 M12888 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 19/21 Gene Ontology BP GO:0060211 2.21321289504106e-07 5.1753788816965e-07 1630 2701.90909090909 2501 2.01201192517419e-08 864 0.872836605827679 -0.945101445014102 -1 6.5326442884863 1629 3792 3752 4522 1921 1068 864 2501 4595 4043 1034 2570 M11178 GO_REGULATION_OF_HORMONE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_LEVELS.html Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. 429/704 Gene Ontology BP GO:0010817 5.05274456621798e-11 1.34345259809213e-09 3695 2052 2502 4.59340415121276e-12 114 2.18919114777725 -2.09312660215597 -1 23.3859780605754 3691 1480 121 1042 270 3611 3021 3186 2502 114 3534 2571 M12489 GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS.html The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. 36/42 Gene Ontology BP GO:0006904 4.57855535285344e-07 8.34796945800434e-07 165 2025.18181818182 2502 4.1623239142955e-08 133 1.15193914550937 -1.16335972031166 -1 8.36520484993781 163 2536 3587 4316 2502 204 133 361 4048 4012 415 2572 M11484 GO_MEMBRANE_RAFT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_RAFT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. 21/25 Gene Ontology BP GO:0031579 7.56881443794536e-06 9.0848112952502e-06 2160 2418.36363636364 2503 6.88076407054037e-07 677 1.89844091161212 -1.90010653277736 -1 11.4725945562157 2158 2125 2542 802 3851 3267 3764 3221 677 1692 2503 2573 M12102 GO_CELLULAR_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 17/23 Gene Ontology BP GO:0071318 1.31259773777343e-06 1.86603033115178e-06 975 2105.63636363636 2503 1.19327138265116e-07 404 2.27624028304925 2.92515666849925 1 15.6685095074418 972 3558 2503 1624 3241 646 661 3339 3619 2595 404 2574 M12106 GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY.html The disaggregation of a beta-catenin destruction complex into its constituent components. 29/34 Gene Ontology BP GO:1904886 1.10238054939296e-07 4.02645553947883e-07 1925 2204.90909090909 2503 1.00216418602843e-08 1151 1.77904891349068 2.17140028760862 1 13.6565431599778 1924 2573 2585 2613 1151 1998 1695 2831 3036 2503 1345 2575 M13031 GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. 31/36 Gene Ontology BP GO:0014742 4.53867012088222e-08 4.02645553947883e-07 4565 2454.27272727273 2503 4.12606383137858e-09 184 1.73191744088459 1.01632363897814 1 13.2920194318121 4561 729 2232 1001 184 4243 3656 2503 1196 2751 3941 2576 M11712 GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 59/69 Gene Ontology BP GO:0070849 4.59439929863019e-07 8.37029754758272e-07 3675 2442.09090909091 2504 4.17672750737088e-08 323 2.19677860716896 2.34067440969656 1 16.0429717543787 3671 323 943 642 2504 4202 3560 4491 1473 1309 3745 2577 M14965 GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 38/40 Gene Ontology BP GO:0061028 6.41556279805662e-08 4.02645553947883e-07 2925 2150.27272727273 2504 5.83232998649546e-09 468 1.71218171599981 -1.75350568143185 -1 13.1393796008189 2922 2529 2538 767 468 3574 1716 1813 1641 3181 2504 2578 M16529 GO_POST_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. 115/154 Gene Ontology BP GO:0009791 1.38273473827425e-07 4.24835370983751e-07 4295 2536 2504 1.25703165925574e-08 1412 1.97271018344398 -1.29746272555571 -1 15.0987724959269 4294 2829 1903 2737 1412 3764 2504 1431 1687 3124 2211 2579 M11155 GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. 81/125 Gene Ontology BP GO:0044259 3.1332288886585e-10 7.21728416778613e-09 1205 2288 2505 2.84838989918613e-11 138 2.73542737458974 2.82165168513433 1 26.8313213812717 1204 2433 138 2177 4192 2932 3426 2505 3295 254 2612 2580 M16945 GO_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. 42/58 Gene Ontology BP GO:0019933 4.92816975982712e-08 4.02645553947883e-07 2585 2171.72727272727 2505 4.4801544274745e-09 240 2.18547305400224 2.42129803332763 1 16.7999043732811 2584 2505 1574 1832 240 3212 4051 2803 1398 1059 2631 2581 M10929 GO_ACTIVATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_GTPASE_ACTIVITY.html Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. 85/108 Gene Ontology BP GO:0090630 2.32142852159472e-08 3.27808193137699e-07 3220 2008.18181818182 2506 2.11038958735482e-09 27 1.64223599445422 -1.48512463274902 -1 12.77577246394 3219 158 2530 1570 27 2872 2506 3942 981 1655 2630 2582 M13708 GO_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. 547/698 Gene Ontology BP GO:0070925 4.96464642300722e-08 4.02645553947883e-07 2405 2597.36363636364 2509 4.96464653392193e-09 323 1.67141467935851 1.83937656925576 1 12.8240796247931 2402 2766 4445 3856 323 1787 2509 2569 2000 3533 2381 2583 M10781 GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. 83/97 Gene Ontology BP GO:0031145 1.10419947786e-05 1.29286365638716e-05 275 2525.18181818182 2510 1.0038227454308e-06 275 1.22957332916826 1.43407174962588 1 7.16637211092988 275 3187 3974 2625 3952 1320 1153 2072 2510 4287 2422 2584 M14374 GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY.html Any process that activates or increases the activity of a cyclase. 43/72 Gene Ontology BP GO:0031281 1.10943621194959e-07 4.02645553947883e-07 3530 2521.72727272727 2511 1.00857842536115e-08 587 1.91879259152509 2.07069359436005 1 14.7373472106054 3526 587 2153 2095 1160 2511 3279 3116 3801 1823 3688 2585 M15618 GO_DORSAL_VENTRAL_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 24/35 Gene Ontology BP GO:0009950 8.75228590314272e-07 1.34587627443892e-06 2390 2575.63636363636 2512 7.95662671370625e-08 1028 1.95869966593502 2.36284177407637 1 13.8045258942764 2388 3533 2378 1028 2983 3029 3436 2214 1645 3186 2512 2586 M15000 GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 24/34 Gene Ontology BP GO:0050858 7.11085218478688e-07 1.14487180677555e-06 1995 2388.45454545455 2513 6.46441316651044e-08 726 2.07926428100649 -2.31362135274884 -1 14.8372290365702 1994 2956 2080 1955 2849 2983 2801 2402 726 2513 3014 2587 M16053 GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION.html The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. 84/99 Gene Ontology BP GO:0035335 8.22375937479999e-08 4.02645553947883e-07 3390 2445.81818181818 2513 7.47614516564555e-09 176 1.8759402021723 -1.52468371473778 -1 14.4059187220826 3388 176 1841 1053 771 4505 4045 3271 2513 1397 3944 2588 M16330 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 24/38 Gene Ontology BP GO:0035774 1.12822521847979e-07 4.05064193023647e-07 4020 2606.18181818182 2514 1.02565934212593e-08 476 2.08384721064665 2.64156003433594 1 16.0073559669803 4016 2091 2281 806 1179 4363 3697 4051 476 2514 3194 2589 M13495 GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 682/869 Gene Ontology BP GO:0051347 8.88987104194154e-08 4.02645553947883e-07 3415 2592.90909090909 2516 8.88987139757569e-09 819 1.89455966455792 1.94668146745577 1 14.5499251676688 3414 1404 4429 819 980 2056 3332 3886 2516 1664 4022 2590 M13791 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. 42/66 Gene Ontology BP GO:0002639 4.36924020307526e-06 5.4871996396516e-06 490 2449.09090909091 2516 3.97204443680934e-07 489 1.36192335196779 -1.28218484594603 -1 8.56189166085875 489 2516 3224 3923 3681 1369 1432 1557 4026 2813 1910 2591 M14053 GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell. 36/77 Gene Ontology BP GO:0050710 8.0310282167795e-07 1.26116686779193e-06 2715 2190.36363636364 2516 7.30093740771058e-08 885 2.46236534012458 -2.77926426987782 -1 17.4648123303058 2516 1993 1131 885 2917 2715 2609 3670 1109 1837 2712 2592 M13071 GO_RESPONSE_TO_SALT_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. 18/30 Gene Ontology BP GO:0009651 4.80688528484115e-06 5.99154493178834e-06 3330 2376.36363636364 2517 4.36990526151543e-07 777 3.2687636515255 -3.34628275871915 -1 20.54265367455 3326 4028 1546 1017 3707 2982 2517 777 1169 2334 2737 2593 M10346 GO_LUNG_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_EPITHELIUM_DEVELOPMENT.html The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. 30/43 Gene Ontology BP GO:0060428 4.44595113592368e-07 8.18764774416964e-07 4115 2790 2518 4.04177457672761e-08 769 1.89084893465232 -1.69616848363997 -1 13.8163548412186 4112 769 2518 2080 2476 3155 3662 4302 2315 1999 3302 2594 M14949 GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS.html The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. 28/37 Gene Ontology BP GO:0046716 1.01991229013329e-05 1.20112677448499e-05 2230 2438.45454545455 2518 9.27197289492374e-07 195 2.05165315514732 1.98077193016135 1 12.1058806305742 2229 3736 2781 2084 3924 2038 2518 2778 987 3553 195 2595 M15146 GO_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. 973/1375 Gene Ontology BP GO:0061024 7.07583191857358e-08 4.02645553947883e-07 2520 2708.18181818182 2518 7.07583214387687e-09 695 1.74831068219109 -1.44925852003076 -1 13.4188078622884 2518 3110 4537 2267 695 2219 1689 3523 1824 4150 3258 2596 M15613 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. 19/21 Gene Ontology BP GO:0060742 2.56249522580028e-07 5.66158133221686e-07 3730 2146.81818181818 2518 2.32954138570203e-08 78 2.37451314165996 2.79920633310799 1 17.8369175379278 3727 950 1490 654 2046 3140 2716 3693 78 2518 2603 2597 M13477 GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of osteoblast proliferation. 40/49 Gene Ontology BP GO:0033688 1.09541134039011e-07 4.02645553947883e-07 3380 2316.63636363636 2519 9.95828540847463e-09 661 2.37594363614852 2.53920120572004 1 18.2730398997297 3376 2519 1520 661 1140 3704 3537 2944 1134 2033 2915 2598 M13676 GO_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the cell cycle. 1059/1342 Gene Ontology BP GO:0051726 1.31311076674897e-07 4.19475731204347e-07 1975 2690.09090909091 2519 1.31311084434067e-08 1462 1.61383170645881 1.77105262118727 1 12.3440119816097 1972 3109 4441 3575 1462 1510 2452 2519 2912 3709 1930 2599 M12098 GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 18/26 Gene Ontology BP GO:0002068 9.35181671271826e-06 1.10750835236137e-05 2675 2250.09090909091 2520 8.50168769627127e-07 84 1.93854355783422 -2.06169368008516 -1 11.5154191225292 2672 2168 2520 772 3902 2365 1468 2687 84 3148 2965 2600 M12377 GO_POSITIVE_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_RATE.html Any process that activates or increases the frequency or rate of heart contraction. 25/35 Gene Ontology BP GO:0010460 1.50241400766341e-07 4.37329540718478e-07 3445 2517.27272727273 2520 1.36583100933236e-08 735 3.3117425481352 -3.48375701890608 -1 25.3669550884701 3441 2594 735 3659 1503 3200 2520 1945 2444 1065 4584 2601 M13638 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS.html The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. 36/43 Gene Ontology BP GO:0002200 8.65336699522234e-06 1.03082735864745e-05 1040 2494.36363636364 2521 7.86672821101729e-07 700 1.37781027811197 1.59191778096738 1 8.20667065086881 1037 3969 3576 3786 3879 1114 700 928 2521 4127 1801 2602 M16933 GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. 420/511 Gene Ontology BP GO:2001233 6.23714091542968e-08 4.02645553947883e-07 2525 2402.27272727273 2522 5.67012826568785e-09 441 1.84915006542485 1.95810764819443 1 14.198718734786 2878 1510 2195 1863 441 1521 3405 4242 2525 2522 3323 2603 M10473 GO_REGULATION_OF_T_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. 7/13 Gene Ontology BP GO:0010819 4.30853847322175e-05 4.74612441190833e-05 560 2205.45454545455 2523 4.30862201126828e-06 101 2.46389256935409 -2.46389256935409 -1 12.7807955253863 560 3613 4242 2594 4207 642 101 834 3817 2523 1127 2604 M12639 GO_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that modulates the frequency, rate or extent of receptor internalization. 42/56 Gene Ontology BP GO:0002090 4.6834661866464e-07 8.46421139016716e-07 3240 2127.09090909091 2523 4.25769743971416e-08 505 2.00438331869625 -1.6440310388078 -1 14.6171546116361 3239 505 1454 559 2523 3703 3722 833 2747 1456 2657 2605 M14235 GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 17/20 Gene Ontology BP GO:0010745 1.50432661251955e-05 1.73344024964177e-05 2125 2575.90909090909 2523 1.36757899906827e-06 1749 2.3053409625954 -1.80018996480045 -1 13.1713129204655 2121 3014 2374 2100 4012 2985 2523 2639 1911 1749 2907 2606 M12592 GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 21/30 Gene Ontology BP GO:0034381 4.7265544234266e-07 8.50450801709357e-07 1300 2347.54545454545 2524 4.2968685808144e-08 1298 2.15804690702483 2.39374478853601 1 15.7402704732575 1298 2614 1997 2541 2537 2244 2527 2524 2844 2436 2261 2607 M14310 GO_RHYTHMIC_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_BEHAVIOR.html The specific behavior of an organism that recur with measured regularity. 19/32 Gene Ontology BP GO:0007622 8.62238099071754e-07 1.33156119315661e-06 2765 2484.72727272727 2525 7.83853124550746e-08 812 2.83938100016051 3.2410702175953 1 20.0736325714384 2761 2624 1700 2081 2972 2525 2371 3040 812 2516 3930 2608 M16268 GO_NEGATIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DEATH.html Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. 210/276 Gene Ontology BP GO:1901215 4.68596787901797e-07 8.46421139016716e-07 4200 2819.27272727273 2525 4.25997170647507e-08 1228 1.85297271666878 2.11987098740019 1 13.5052010939332 4196 2368 2023 1228 2525 4036 2907 3075 2163 1931 4560 2609 M10537 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 21/23 Gene Ontology BP GO:1902254 1.54335538615699e-06 2.14621416969171e-06 2955 2411.36363636364 2526 1.40305133532792e-07 587 1.92255788513258 2.0191959011317 1 13.076675479433 2953 2114 2526 1824 3314 2013 1794 3409 587 3437 2554 2610 M13353 GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION.html Any recombinational process that contributes to the maintenance of proper telomeric length. 32/33 Gene Ontology BP GO:0000722 0.000188181193663921 0.000198911198118634 95 2104.81818181818 2527 1.71088447298976e-05 52 1.25513023943447 1.29945699769164 1 5.515496768343 91 2914 3416 2527 4390 334 52 1179 3892 2542 1816 2611 M13602 GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS.html The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. 93/145 Gene Ontology BP GO:0044236 4.11802181835105e-11 1.13379618466198e-09 1455 2285 2527 3.74365619857104e-12 116 2.82363935504288 2.77872106002778 1 30.4449279315919 1452 2417 116 2167 4032 2931 3689 2696 2887 221 2527 2612 M16619 GO_NUCLEOTIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SALVAGE.html Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. 12/14 Gene Ontology BP GO:0043173 4.69069853388707e-07 8.46908110114539e-07 1555 2300.54545454545 2527 4.26427230364359e-08 145 1.062232934861 1.07780747002964 1 7.69771828022013 1551 2712 3324 4319 2527 696 145 1799 4312 3088 833 2613 M16177 GO_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 20/24 Gene Ontology BP GO:0070227 3.14485636900094e-08 3.85079386446352e-07 2980 2401.81818181818 2529 2.85896037632367e-09 74 1.2614817180895 1.27001028304796 1 9.68313605465174 2976 2147 3530 2337 74 1885 1212 3550 3118 3062 2529 2614 M10358 GO_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. 25/56 Gene Ontology BP GO:0097028 8.58115834841006e-07 1.32695173651424e-06 2305 2527.90909090909 2530 7.80105608683223e-08 866 1.65976152447173 -1.47793594716728 -1 11.6943007876371 2302 2587 2472 2530 2967 2105 866 4614 1891 2628 2845 2615 M10794 GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. 33/44 Gene Ontology BP GO:0051145 5.93872550166558e-07 1.00739663723113e-06 4110 2394.81818181818 2530 5.39884282252549e-08 553 2.2364779039937 -2.04886230460134 -1 16.1171281231999 4109 663 1035 1147 2700 4143 4293 1635 2530 553 3535 2616 M11588 GO_CREATINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CREATINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. 8/10 Gene Ontology BP GO:0006600 1.51747783241985e-05 1.746431945152e-05 2530 2365.27272727273 2530 1.51748819484481e-06 5 1.90468629130722 -1.51011457280711 -1 10.8568530693087 2530 1260 4313 745 4042 1290 510 4061 5 2817 4445 2617 M12559 GO_ATRIAL_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_MORPHOGENESIS.html The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. 13/20 Gene Ontology BP GO:0060413 1.2057563506587e-06 1.73320491183656e-06 1595 2305.36363636364 2530 1.09614273772671e-07 669 1.84998425991298 -2.18734228597358 -1 12.786843799731 1594 3817 2595 3542 3196 2530 669 1193 2570 1811 1842 2618 M15452 GO_MONOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 197/276 Gene Ontology BP GO:0005996 3.93536000567256e-07 7.50765215604951e-07 2535 2528.90909090909 2532 3.57760064511812e-08 1879 1.86459340300671 -1.78495741060911 -1 13.7079904632141 2532 2793 2454 2219 2389 3086 2704 1879 2135 2823 2804 2619 M11152 GO_RESPONSE_TO_MORPHINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MORPHINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. 28/40 Gene Ontology BP GO:0043278 4.7111485634191e-07 8.48610560170626e-07 1180 2323.72727272727 2533 4.28286324752676e-08 754 1.79300475426225 -1.71877739250053 -1 13.0623658755944 1177 3733 2605 3728 2533 943 754 2547 3678 1713 2150 2620 M14947 GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. 25/50 Gene Ontology BP GO:0045143 3.80405975605703e-05 4.20634269128644e-05 220 1940.36363636364 2533 3.45829594030368e-06 20 1.65114955268395 1.70265317033951 1 8.63564897337144 219 3529 3222 2533 4196 98 20 516 3345 3560 106 2621 M16367 GO_PHOSPHOLIPID_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_EFFLUX.html The directed movement of a phospholipid out of a cell or organelle. 9/18 Gene Ontology BP GO:0033700 5.82928288121506e-06 7.15097633701388e-06 2535 2629.45454545455 2533 5.82929817251401e-07 294 2.74870604241142 3.32278068902463 1 17.0025611707128 2533 2285 4618 792 3805 2836 3921 4461 294 1908 1471 2622 M11206 GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. 203/249 Gene Ontology BP GO:0051054 6.22042187951957e-07 1.0419697559094e-06 1320 2519.45454545455 2534 5.65493058029315e-08 689 1.52583446526003 1.49626207652207 1 10.9361343232157 1316 3882 3730 3115 2735 745 689 2387 2455 4126 2534 2623 M16143 GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. 257/339 Gene Ontology BP GO:0034612 2.6805694063343e-07 5.77706783125219e-07 2295 2917.27272727273 2534 2.4368815754053e-08 1925 1.95982274356423 -1.81742592579192 -1 14.6830707169142 2294 4120 1925 3327 2099 2534 2226 4548 3656 2996 2365 2624 M16195 GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. 28/40 Gene Ontology BP GO:0014072 4.7111485634191e-07 8.48610560170626e-07 1180 2325.27272727273 2534 4.28286324752676e-08 755 1.79300475426225 -1.71877739250053 -1 13.0623658755944 1178 3734 2606 3729 2534 944 755 2548 3679 1720 2151 2625 M10677 GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of dendritic cell differentiation. 26/50 Gene Ontology BP GO:2001198 8.28554123909346e-06 9.88528804756458e-06 455 2440.09090909091 2535 7.53233858535587e-07 451 1.41895718081736 -1.26177125191277 -1 8.48605614338984 451 2568 2777 2535 3874 1674 1754 2475 3660 2437 2636 2626 M14062 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 46/74 Gene Ontology BP GO:0010524 5.17449502887118e-07 9.0651074432747e-07 2535 2139.18181818182 2535 4.70408749630469e-08 492 2.1080807557431 2.10098005079921 1 15.302763735991 2535 492 1487 2671 2610 1941 2627 2753 2196 1398 2821 2627 M15449 GO_KERATINIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINIZATION.html The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. 26/66 Gene Ontology BP GO:0031424 4.71267931975263e-07 8.48610560170626e-07 4240 2559.09090909091 2535 4.28425484478971e-08 563 3.49177871216316 -2.61044381245401 -1 25.5357901390018 4238 804 563 2162 2535 4141 4560 2629 1338 953 4227 2628 M15511 GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT.html Any process that modulates the frequency, rate or extent of the movement of a cellular component. 865/1139 Gene Ontology BP GO:0051270 3.12690768248304e-19 2.9692860095089e-17 2545 2230.54545454545 2535 3.12690768248306e-20 25 2.3094499138185 2.44002064670921 1 46.0586289309918 2543 1368 4560 298 376 2993 4493 2535 1961 25 3384 2629 M13689 GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex assembly. 418/505 Gene Ontology BP GO:0043254 1.20767468854096e-07 4.11483088288319e-07 2505 2538.36363636364 2536 1.09788614075948e-08 1249 1.83681556975581 -1.79023696564633 -1 14.0823752708275 2505 2771 3066 1415 1249 2804 2536 3881 2219 4105 1371 2630 M10871 GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. 150/179 Gene Ontology BP GO:0035567 4.73162867726088e-07 8.51034721116926e-07 1440 2729.90909090909 2538 4.30148154082876e-08 1436 1.28975109751915 1.43880309146051 1 9.3652412397102 1436 3145 4024 3116 2538 1631 1856 2195 3736 4123 2229 2631 M11546 GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of B cell proliferation. 35/57 Gene Ontology BP GO:0030890 1.18423311802837e-07 4.09676049985113e-07 2640 2466.72727272727 2538 1.07657561979473e-08 1213 2.07824363182996 -1.83494214978844 -1 15.9516766569935 2639 2538 1919 2945 1228 1907 1213 3910 3807 1733 3295 2632 M14584 GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. 387/605 Gene Ontology BP GO:0051346 7.6715306986576e-08 4.02645553947883e-07 3535 2272.63636363636 2538 6.97411906015315e-09 240 2.23833979952863 2.43688043222161 1 17.2087857875398 3531 1516 240 1267 867 3762 4036 2538 2874 431 3937 2633 M16689 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. 18/23 Gene Ontology BP GO:0034391 1.10934261053027e-07 4.02645553947883e-07 3500 2324.18181818182 2538 1.00849333315318e-08 1037 1.88017876203278 2.09628434726147 1 14.4387005461369 3499 2192 2577 1037 1159 2692 1273 2964 2538 3460 2175 2634 M12973 GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. 10/13 Gene Ontology BP GO:0060576 0.000697322625302635 0.000721994253567681 3230 2727.36363636364 2539 6.34130681982139e-05 1224 1.61587109232418 1.76810881816271 1 6.03619044932737 3226 3600 2539 3243 4471 2391 1412 1224 4012 1617 2266 2635 M15957 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. 55/133 Gene Ontology BP GO:0002440 2.17702186244325e-07 5.14458239001953e-07 3980 2909.27272727273 2539 1.97911097988332e-08 1900 2.09392330685833 -2.23022106901815 -1 15.8223265816084 3980 2486 2204 2539 1900 4467 3948 2049 2214 3196 3019 2636 M16156 GO_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the cell. 599/901 Gene Ontology BP GO:0019725 5.2744980641943e-08 4.02645553947883e-07 3455 2390.36363636364 2539 5.27449818938578e-09 324 2.11610325135691 -1.95459822315397 -1 16.2633851922714 3455 2329 4599 1247 375 3306 2606 2539 2015 324 3499 2637 M16505 GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 33/41 Gene Ontology BP GO:0043536 1.61786181027937e-07 4.47025594016029e-07 1970 2316.72727272727 2539 1.47078357205055e-08 702 1.61783389065835 1.432695314398 1 12.3208272929754 1967 2539 2578 1601 1598 1108 702 4003 3070 2660 3658 2638 M10706 GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization of an epithelial cell. 33/37 Gene Ontology BP GO:0090162 1.12507873799953e-06 1.63798228032284e-06 2365 2522.81818181818 2540 1.02279937578596e-07 465 1.42788072802116 -1.43652250828285 -1 9.88820791182275 2361 2540 3179 2093 3165 2466 465 2333 2999 2980 3170 2639 M15873 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. 79/96 Gene Ontology BP GO:2001022 9.71225340128566e-08 4.02645553947883e-07 2225 2198.36363636364 2540 8.82932166368068e-09 618 1.74776847729022 1.85441646720809 1 13.4146143469797 2225 3455 2918 3532 971 618 656 2675 3028 2540 1564 2640 M15070 GO_MOTILE_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM_ASSEMBLY.html The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function. 33/57 Gene Ontology BP GO:0044458 3.338396499717e-07 6.73031148751438e-07 2545 2570.18181818182 2542 3.03490636936642e-08 642 2.49773938645856 2.40913054482426 1 18.5410628405036 2542 3715 1926 2295 2253 2515 3301 2585 642 2984 3514 2641 M15834 GO_CYTOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOLYSIS.html The rupture of cell membranes and the loss of cytoplasm. 22/49 Gene Ontology BP GO:0019835 5.36237067799247e-07 9.32130335465133e-07 4450 2619.36363636364 2542 4.87488362276295e-08 846 2.90790603640697 2.31999118806856 1 21.1052701562571 4450 912 846 1068 2629 4650 4287 1864 2542 1847 3718 2642 M11456 GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. 171/214 Gene Ontology BP GO:1901293 1.84203871147191e-07 4.7749337740829e-07 1435 2618.18181818182 2545 1.67458078700368e-08 1433 1.50107537862842 1.46347733219999 1 11.3722232074495 1433 2803 3498 3862 1712 2065 2017 2320 2545 3227 3318 2643 M13588 GO_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that modulates the frequency, rate or extent of muscle hypertrophy. 45/55 Gene Ontology BP GO:0014743 1.46122671049358e-08 2.33645631750056e-07 4645 2590.81818181818 2546 1.32838792745360e-09 3 1.72451473209066 1.35528401982619 1 13.7277343924786 4643 510 2354 991 3 4081 4116 4029 878 2546 4348 2644 M15708 GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. 18/27 Gene Ontology BP GO:0039531 0.000443681950124528 0.00046091808750378 715 2427.72727272727 2546 4.03428594853321e-05 711 1.60813324331286 -1.90613242277853 -1 6.38586718236937 711 2997 2563 1649 4455 1798 890 3430 3324 2342 2546 2645 M16487 GO_ADIPOSE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADIPOSE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. 45/50 Gene Ontology BP GO:0060612 5.90563412649644e-07 1.00288013104336e-06 2180 2700.54545454545 2547 5.36875973799378e-08 1654 2.06836530277985 2.16726364737436 1 14.902770787002 2180 3214 2438 4158 2698 1922 2316 2873 3706 2547 1654 2646 M15756 GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. 35/50 Gene Ontology BP GO:1904837 1.68827371912757e-07 4.56186853374019e-07 2300 2654.45454545455 2548 1.53479440789567e-08 1447 1.31840742945431 1.55895325067298 1 10.0074023581107 2298 3233 3469 2548 1637 3062 4583 1447 1521 3819 1582 2647 M13735 GO_POSITIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPAIR.html Any process that activates or increases the frequency, rate or extent of DNA repair. 46/61 Gene Ontology BP GO:0045739 4.61714966082485e-07 8.3887533665826e-07 4315 2823.18181818182 2549 4.19740966348033e-08 1601 1.56627985068408 1.38320667730069 1 11.4071068388195 4314 2508 3108 3762 2511 3234 1601 2397 2549 3381 1690 2648 M16707 GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 11/13 Gene Ontology BP GO:0051533 8.24152799396642e-07 1.28640824407668e-06 3010 2201.09090909091 2549 7.49230098306118e-08 944 1.50568805137361 -1.93838400536127 -1 10.6237168634027 3010 1198 2824 1440 2937 3271 2549 1060 944 3351 1628 2649 M10591 GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. 250/338 Gene Ontology BP GO:0070302 3.55510418472135e-07 6.991790307027e-07 3330 2686.45454545455 2550 3.2319134174644e-08 1614 1.73647984529388 -1.51273652136027 -1 12.8239858537786 3327 1614 2550 1678 2309 3030 2285 3837 3250 2163 3508 2650 M15266 GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 28/33 Gene Ontology BP GO:0060317 7.66032920105817e-07 1.2125893027406e-06 2715 2271.72727272727 2550 6.96393806214677e-08 756 2.64301001281258 -2.53010165879184 -1 18.8081512067017 2715 2550 756 1772 2895 3181 2495 2737 1925 947 3016 2651 M15339 GO_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G2_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. 41/46 Gene Ontology BP GO:0031572 3.48916326687765e-07 6.93400828564493e-07 2910 2604 2550 3.17196710932112e-08 2026 1.5475663210197 1.89466912635647 1 11.4243950440955 2910 2520 3215 2550 2283 2587 2682 2442 2026 2159 3270 2652 M12567 GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. 20/24 Gene Ontology BP GO:2000269 9.00814890273623e-07 1.37923385470325e-06 2745 2336 2551 8.18922962838802e-08 72 2.1484866535683 2.36705264936018 1 15.1244549716371 2741 966 2215 2551 3000 2442 3194 1856 72 3385 3274 2653 M13152 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 1392/1994 Gene Ontology BP GO:0051240 8.19679777763371e-30 9.53492501483241e-27 2725 2170.27272727273 2551 8.19679777763365e-31 4 2.26285984480123 2.41335359951385 1 71.1077582506258 2724 1317 4412 287 307 2551 4533 2624 2049 4 3065 2654 M14501 GO_CELLULAR_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. 145/207 Gene Ontology BP GO:0009267 1.17352074311107e-06 1.69472129661571e-06 1625 2444 2552 1.06683760826294e-07 982 2.03007916824546 -1.75611081279172 -1 14.065600522102 1625 3893 2408 2552 3185 982 1179 3423 2858 3428 1351 2655 M10465 GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 55/64 Gene Ontology BP GO:0071364 4.82784618675417e-07 8.63334677439168e-07 3170 2347.36363636364 2553 4.38895204201231e-08 344 2.2488804072352 2.34067440969656 1 16.3893613353233 3166 344 777 632 2553 3647 3759 4203 1422 1194 4124 2656 M13150 GO_TETRAHYDROFOLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. 19/20 Gene Ontology BP GO:0046653 4.89045001158775e-06 6.08917953008237e-06 610 2622.18181818182 2553 4.4458735297805e-07 608 1.25613396934634 1.24860584908581 1 7.82015840047869 608 2181 3236 3885 3713 1887 2407 1752 3700 2922 2553 2657 M11443 GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. 31/34 Gene Ontology BP GO:1901889 1.248096814362e-07 4.14431426073273e-07 3555 2411.63636363636 2555 1.13463353197148e-08 384 1.89055932421441 -2.72833060205418 -1 14.4903372380987 3554 2560 2555 2049 1290 4012 3683 384 2205 3067 1169 2658 M13391 GO_VITAMIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 14/24 Gene Ontology BP GO:0009110 3.51371904601755e-06 4.48418396081176e-06 2755 2473.18181818182 2555 3.19429514358999e-07 768 2.64332830173421 -3.16676276688281 -1 16.9947236720187 2753 1129 1821 2661 3620 2900 2545 3964 768 2489 2555 2659 M16118 GO_IMMUNOLOGICAL_SYNAPSE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE_FORMATION.html The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 23/51 Gene Ontology BP GO:0001771 4.83421014655376e-07 8.63808748537429e-07 3760 2452.18181818182 2555 4.39473746255279e-08 191 2.1592448373245 2.5248241240201 1 15.73139013129 3757 876 1575 631 2555 3399 4215 4262 191 1662 3851 2660 M13030 GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 8/21 Gene Ontology BP GO:0042423 4.39777388046699e-07 8.13003638007822e-07 3790 2993.90909090909 2556 4.39777475078591e-08 1266 2.34817594876402 2.8581091216455 1 17.1916350473315 3787 1266 4402 2466 2556 4612 4363 1820 2071 1584 4006 2661 M13885 GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE.html A process of chromosome organization that is involved in a meiotic cell cycle. 31/56 Gene Ontology BP GO:0070192 2.16703765552422e-06 2.89415218460224e-06 85 1831.27272727273 2556 1.97003617281486e-07 17 1.52289474455821 1.5547354634639 1 10.0977282790725 85 3252 3415 2556 3453 47 17 286 3649 3303 81 2662 M10240 GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that activates or increases the frequency, rate or extent of protein binding. 115/132 Gene Ontology BP GO:0032092 1.07608558692698e-07 4.02645553947883e-07 2560 2797 2557 9.78259672328668e-09 1109 1.70477265617066 -1.44475266748623 -1 13.0820765300301 2557 3899 3407 3589 1109 2532 1946 2499 3887 2824 2518 2663 M13996 GO_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 27/41 Gene Ontology BP GO:0071887 2.41108840823994e-07 5.48853038928409e-07 4450 2796.81818181818 2557 2.19189879316639e-08 1416 1.77989512650234 -2.33126472159999 -1 13.3734917814953 4448 2053 2710 1416 1981 3707 2344 3711 1830 2557 4008 2664 M15166 GO_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. 316/378 Gene Ontology BP GO:0033044 8.7845805414168e-07 1.34944381839592e-06 1490 2657.54545454545 2557 7.98598549917637e-08 1487 1.60274285382433 1.68741860649104 1 11.2748739288652 1487 3879 3965 2633 2986 1890 1938 1607 2557 4298 1993 2665 M16878 GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. 8/21 Gene Ontology BP GO:0009713 4.39777388046699e-07 8.13003638007822e-07 3790 3017.63636363636 2557 4.39777475078591e-08 1267 2.34817594876402 2.8581091216455 1 17.1916350473315 3788 1267 4650 2467 2557 4613 4364 1819 2072 1590 4007 2666 M10614 GO_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 387/549 Gene Ontology BP GO:0001101 1.1806583349343e-08 1.92758008156116e-07 3115 2215.45454545455 2558 1.07332576479132e-09 201 2.36599526986279 2.54458159735052 1 19.1114982765277 3111 1522 201 601 1563 2680 4544 4136 2558 492 2962 2667 M16438 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 14/17 Gene Ontology BP GO:0032230 3.23272408523308e-05 3.60025494700563e-05 1835 2548.72727272727 2558 2.93888326227801e-06 1197 2.64482484941665 -2.35563477476251 -1 14.1107508055955 1833 3578 1833 2712 4154 2558 1197 1949 3030 2497 2695 2668 M15499 GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS.html The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. 28/31 Gene Ontology BP GO:0035313 5.91991946177027e-06 7.25153237069817e-06 1445 2268.18181818182 2559 5.3817594468897e-07 365 3.12917026205874 3.12820923967233 1 19.3472841152894 1444 2559 365 966 4356 2765 3968 3444 1666 767 2650 2669 M16870 GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. 206/365 Gene Ontology BP GO:0010466 1.78868437577869e-07 4.7101009623646e-07 1935 2280.18181818182 2559 1.62607683745964e-08 275 2.43322356715279 2.54865827861832 1 18.5156320253625 1931 2369 275 2654 1685 2559 3359 2771 3513 942 3024 2670 M14438 GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of B cell proliferation. 20/36 Gene Ontology BP GO:0030889 6.38261562658706e-05 6.92268310268288e-05 940 2502.63636363636 2560 5.80254618713264e-06 562 2.04341214534541 -2.19540650154092 -1 10.1769603732565 939 3553 2560 3032 4386 1965 815 562 4350 3060 2307 2671 M15503 GO_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_CHEMOTAXIS.html The movement of a monocyte in response to an external stimulus. 21/54 Gene Ontology BP GO:0002548 8.93560620810087e-06 1.0614596805283e-05 2000 2710.72727272727 2561 8.12331136501415e-07 1064 3.08385905428347 -3.17946699950331 -1 18.448486932842 1999 3775 1064 3421 3890 2760 2561 2297 4284 2071 1696 2672 M15915 GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. 44/101 Gene Ontology BP GO:0002715 1.55985727199167e-06 2.16463342874358e-06 2035 2863.27272727273 2561 1.4180530708838e-07 1673 1.67676048700871 -1.03736269912066 -1 11.3841444823949 2032 1918 2032 2479 3321 2561 3834 4510 3861 1673 3275 2673 M11012 GO_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PHASE_TRANSITION.html The cell cycle process by which a cell commits to entering the next cell cycle phase. 311/387 Gene Ontology BP GO:0044770 1.1369549232748e-06 1.65320351812427e-06 185 2114.90909090909 2563 1.03359591895537e-07 184 1.51382851070388 1.65696195251359 1 10.4822470302076 184 3121 3812 2563 3168 697 517 1158 3146 3050 1848 2674 M14730 GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by a ligand binding to an receptor located within a cell. 184/294 Gene Ontology BP GO:0030522 4.86703417601092e-07 8.68007283287805e-07 1605 2519.18181818182 2563 4.42457750249046e-08 1181 1.70092146304798 -1.70294633684678 -1 12.3660445351589 1602 3885 3443 3017 2563 1778 1620 1181 2998 3291 2333 2675 M10697 GO_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_DNA_REPLICATION.html The DNA-dependent DNA replication that takes place as part of the cell cycle. 12/13 Gene Ontology BP GO:0044786 0.000107366582559896 0.000114792442245219 420 2280.81818181818 2564 9.76107479349154e-06 59 1.62817837837968 1.62817837837968 1 7.65552446784185 417 3378 3165 2564 4323 641 59 1924 3431 3077 2110 2676 M14682 GO_KIDNEY_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. 15/27 Gene Ontology BP GO:0072074 8.26883410251634e-06 9.8729497251754e-06 3525 2658.45454545455 2564 7.51715016508809e-07 958 2.49276192948075 -2.20856613772752 -1 14.9874815337471 3525 2209 1626 958 3871 3702 3158 4103 1292 2235 2564 2677 M12936 GO_RESPONSE_TO_ISCHEMIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISCHEMIA.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. 39/46 Gene Ontology BP GO:0002931 8.40384768689093e-07 1.3043063137793e-06 1535 2312.54545454545 2565 7.63986445191298e-08 647 1.66121672709052 -1.41903853351212 -1 11.71966295407 1535 2890 2714 2099 2954 1373 647 4393 2616 1652 2565 2678 M13822 GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. 60/84 Gene Ontology BP GO:1904888 6.15543132765217e-07 1.03360598944661e-06 2775 2241.63636363636 2565 5.59584822717757e-08 365 1.84305722295627 1.91762398552282 1 13.2389760721725 2773 365 1842 2042 2728 2607 3231 1968 2565 2959 1578 2679 M14815 GO_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_FUSION.html The joining of two or more lipid bilayer membranes that surround a cell. 17/32 Gene Ontology BP GO:0045026 1.83810644015756e-07 4.7749337740829e-07 2725 2493.90909090909 2565 1.67100599430174e-08 960 2.68466390494724 -2.51097585740689 -1 20.420331497262 2722 3790 2053 4109 1707 3105 2565 960 1378 3013 2031 2680 M11186 GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. 12/23 Gene Ontology BP GO:0031645 8.42350210560547e-07 1.30648517657941e-06 2325 2453.90909090909 2566 7.65773211895644e-08 662 2.76852173670809 -2.82442079691279 -1 19.5977531644797 2321 3591 2426 2121 2956 2714 2911 662 4054 2566 671 2681 M12077 GO_NEGATIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BINDING.html Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 66/89 Gene Ontology BP GO:0043392 7.2815514891125e-05 7.86468409443836e-05 1180 2775.72727272727 2570 6.61981136799094e-06 1180 1.81463428196954 -1.81695267531975 -1 8.90443701480102 1180 3467 2643 3607 4278 2290 1410 2363 4177 2548 2570 2682 M14089 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 27/43 Gene Ontology BP GO:0051024 1.06773067775932e-05 1.25300147379927e-05 150 2213.18181818182 2570 9.70668963485939e-07 146 1.21654922241076 -1.20217339145481 -1 7.10938386134543 146 2570 3074 2585 3940 838 1103 1190 4234 2915 1750 2683 M15211 GO_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRITY_CHECKPOINT.html A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. 173/197 Gene Ontology BP GO:0031570 3.71063843675509e-07 7.1820302188941e-07 2245 2465.45454545455 2570 3.37330823873772e-08 1109 1.68585022651456 1.86330593239146 1 12.4233110753475 2241 3428 3440 2960 2350 1109 1572 2570 1624 3102 2724 2684 M13546 GO_KERATAN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 12/15 Gene Ontology BP GO:0042340 3.62200234337177e-08 4.02645553947883e-07 2580 2554.36363636364 2572 3.29272945727558e-09 109 1.68908887175919 -0.978545873304559 -1 12.9607751734356 2580 1179 2321 3697 109 3092 2339 4397 3667 2572 2145 2685 M10216 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 77/133 Gene Ontology BP GO:0034763 5.78278506196725e-08 4.02645553947883e-07 2550 2328.27272727273 2573 5.25707746724544e-09 238 1.67346084569413 1.47766852845468 1 12.8399050624437 2546 238 2658 2576 373 1576 2573 4435 3305 2397 2934 2686 M10147 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT.html The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. 9/15 Gene Ontology BP GO:0010248 1.33637724358925e-06 1.89578149829902e-06 3025 2916.36363636364 2575 1.33637804724679e-07 1814 2.12773389838264 1.70077818313852 1 14.6218706904251 3022 2286 4228 1814 3291 2373 2352 2575 3719 1899 4521 2687 M11164 GO_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 28/34 Gene Ontology BP GO:0010874 1.33567132663879e-05 1.54598972210207e-05 3025 2455.72727272727 2576 1.21425403261815e-06 403 2.85939122574682 3.91971613202443 1 16.5334399940584 3024 2576 1751 811 3992 3292 3913 3012 403 2056 2183 2688 M15824 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. 27/35 Gene Ontology BP GO:2000352 1.06780290399465e-06 1.56982208919024e-06 2800 2523 2577 9.70730383881013e-08 1268 2.40449446302536 2.13473946794695 1 16.7754465212268 2800 2577 1268 1787 3129 2843 3497 2566 2101 1290 3895 2689 M12022 GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS.html The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. 8/15 Gene Ontology BP GO:0048703 7.66175059113985e-07 1.2125893027406e-06 1590 2250.72727272727 2578 7.66175323275012e-08 79 2.55249207349153 3.49991490905613 1 18.160482598108 1590 3092 4339 1816 4376 2578 3023 79 223 2818 824 2690 M12292 GO_KIDNEY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. 25/30 Gene Ontology BP GO:0061440 1.28729452220929e-05 1.4944564400798e-05 3490 2546.81818181818 2578 1.17027459515209e-06 946 2.76715500049563 3.12398284773593 1 16.046067794635 3489 2578 946 1332 3980 2674 4037 1731 2053 1064 4131 2691 M11429 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION.html Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. 22/23 Gene Ontology BP GO:0010569 1.33739425586684e-06 1.896068090356e-06 1735 2649.63636363636 2579 1.21581369898015e-07 1062 1.53911317267859 1.70142426166728 1 10.5482413495637 1732 3536 3191 3500 3250 1916 1062 2022 3792 2579 2566 2692 M14598 GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. 25/30 Gene Ontology BP GO:0061437 1.28729452220929e-05 1.4944564400798e-05 3490 2512.45454545455 2579 1.17027459515209e-06 947 2.76715500049563 3.12398284773593 1 16.046067794635 3490 2579 947 1333 3981 2675 4038 1341 2054 1067 4132 2693 M10095 GO_REGULATION_OF_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_BURST.html Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 12/20 Gene Ontology BP GO:0060263 5.43546564466314e-06 6.70676787181585e-06 2605 2320.18181818182 2580 4.94134461266441e-07 817 1.69375568491275 -1.55251887773116 -1 10.4945346230461 2604 2722 2580 2752 3746 1700 817 1701 1683 3074 2143 2694 M11809 GO_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 31/55 Gene Ontology BP GO:0035456 2.76313001272085e-06 3.59732623088699e-06 1165 2625.90909090909 2580 2.51193953011849e-07 1161 2.0956440288108 -2.4248235877357 -1 13.6947279716624 1161 3724 2339 3177 3545 2254 1342 2462 3552 2749 2580 2695 M12935 GO_LEFT_RIGHT_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). 16/20 Gene Ontology BP GO:0070986 5.05836517332625e-07 8.91796781339768e-07 4155 2484.72727272727 2583 4.59851485124974e-08 505 1.9675912656106 -1.80035119010017 -1 14.2929873271976 4153 2179 1938 1144 2591 3940 4322 2754 505 1223 2583 2696 M16760 GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 232/280 Gene Ontology BP GO:0009895 1.50401396636649e-07 4.37329540718478e-07 2540 2456.27272727273 2584 1.36728551744302e-08 1225 1.58157257955221 -1.47078884993332 -1 12.0605830682083 2539 1635 3358 1225 1504 2709 3267 2914 2584 3556 1728 2697 M10766 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. 15/21 Gene Ontology BP GO:0043302 1.22867011552503e-06 1.76287451357939e-06 2585 2300.72727272727 2585 1.11697345611013e-07 353 2.19163573491485 -2.21698164792273 -1 15.1477685901892 2585 4059 2666 1859 3202 1752 353 1037 1283 3129 3383 2698 M12978 GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. 5/26 Gene Ontology BP GO:0002827 7.38793504441863e-07 1.17645659690896e-06 2285 2540.72727272727 2585 7.38793750059105e-08 1286 1.82407017565831 -2.05592910020967 -1 12.9775036691295 2281 1286 4397 3227 2927 2585 2087 1781 2586 2617 2174 2699 M16214 GO_RUFFLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. 27/42 Gene Ontology BP GO:0031529 3.79025585375463e-06 4.80939746046367e-06 2705 2289.36363636364 2585 3.44569307617119e-07 766 1.77426573124326 -1.39982102107542 -1 11.3081708779626 2702 2585 2733 1431 3643 2307 766 1612 1147 3204 3053 2700 M13439 GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. 93/123 Gene Ontology BP GO:0006767 5.03087829163908e-07 8.89049627459045e-07 3870 2731.63636363636 2586 4.5735267655291e-08 146 1.85187568412136 -1.86148405229738 -1 13.4493514363844 3868 146 2239 3142 2586 4625 4476 2498 1230 1698 3540 2701 M16677 GO_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERK1_AND_ERK2_CASCADE.html An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 22/29 Gene Ontology BP GO:0070371 4.84690664116285e-07 8.65412762906015e-07 2595 2877.09090909091 2587 4.40627973545842e-08 1475 2.13617234970759 -2.06354569971389 -1 15.5601116046419 2592 3286 2061 2555 2559 3374 2468 4239 4452 2587 1475 2702 M11707 GO_INSEMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSEMINATION.html The introduction of semen or sperm into the genital tract of a female. 9/18 Gene Ontology BP GO:0007320 1.14623519128518e-06 1.66357839833123e-06 1550 2576.63636363636 2588 1.14623578252041e-07 550 2.85265197175405 3.17499916261497 1 19.83438345931 1547 3390 4321 3687 3216 1880 2588 1208 3505 2451 550 2703 M14809 GO_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 141/173 Gene Ontology BP GO:0071156 2.78601814245516e-06 3.62509575415096e-06 2210 2717.18181818182 2588 2.5327469732695e-07 1654 1.61748448163149 1.71755782869279 1 10.5400004109793 2210 3147 3419 3046 3548 1654 2092 2588 2536 3615 2034 2704 M16769 GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of tight junction assembly. 19/24 Gene Ontology BP GO:2000810 1.31087442184434e-05 1.51955622442494e-05 3225 2471.63636363636 2588 1.19171112071008e-06 629 2.74788253470972 -2.78584468025573 -1 15.9095553158006 3223 4020 2287 1163 3987 2588 1191 2931 629 3839 1330 2705 M13021 GO_LYSOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_LOCALIZATION.html Any process in which a lysosome is transported to, and/or maintained in, a specific location. 25/47 Gene Ontology BP GO:0032418 1.3318338195413e-06 1.89048894518782e-06 4280 2577.81818181818 2589 1.21075875073293e-07 463 1.91791834618032 -2.09809521483237 -1 13.1726735675198 4279 2589 2253 1629 3247 4116 3425 828 463 2992 2535 2706 M10569 GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 41/50 Gene Ontology BP GO:0090329 4.78602536397922e-06 5.96714255589371e-06 105 2077.36363636364 2590 4.35094161440613e-07 64 1.37811171961567 1.51095855016649 1 8.60419213145099 102 3498 3531 2590 3706 282 64 1229 3102 3418 1329 2707 M13512 GO_POSITIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXON_EXTENSION.html Any process that activates or increases the frequency, rate or extent of axon extension. 49/54 Gene Ontology BP GO:0045773 1.32983856810631e-07 4.20399283289481e-07 2790 2626.36363636364 2590 1.20894422590123e-08 1367 2.2568336489934 2.54839500185902 1 17.3006741698571 2790 3207 1600 2270 1367 3789 4270 2042 2590 2210 2755 2708 M13729 GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. 11/24 Gene Ontology BP GO:0042753 1.50624224840441e-06 2.09981220888597e-06 2175 2555.90909090909 2590 1.36931207242049e-07 1108 1.58248937633707 -1.15533298696989 -1 10.7635850862923 2173 2270 2822 3231 3305 1873 1108 2182 3217 3344 2590 2709 M11008 GO_LYMPHOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. 53/71 Gene Ontology BP GO:0002260 9.26174232771663e-08 4.02645553947883e-07 4505 2381.18181818182 2591 8.41976610693195e-09 429 1.78934577918788 1.87489352479342 1 13.7361810678305 4503 429 2591 1013 913 3872 2379 2989 447 3064 3993 2710 M11860 GO_PEPTIDYL_PROLINE_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_HYDROXYLATION.html The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. 11/13 Gene Ontology BP GO:0019511 6.63241354334235e-06 8.02825708042975e-06 1500 2308.63636363636 2592 6.02948503489597e-07 214 1.94304593759395 2.39196010962255 1 11.8707470296932 1499 3836 2592 2660 4274 2448 4084 214 469 2900 419 2711 M16577 GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING.html The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. 58/65 Gene Ontology BP GO:0061077 4.68495872897038e-07 8.46421139016716e-07 1865 2977.27272727273 2594 4.25905429695012e-08 1587 1.4690614212999 1.59139930589436 1 10.6857716110897 1587 4414 3661 4148 2524 2205 1863 1862 3912 3980 2594 2712 M13416 GO_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_URINE_VOLUME.html Any process that modulates the amount of urine excreted from the body over a unit of time. 18/30 Gene Ontology BP GO:0035809 3.53765318294869e-07 6.96896708732441e-07 2600 2401.36363636364 2596 3.21604886528364e-08 712 2.64909558581876 2.49374500231972 1 19.6223556359926 2596 1001 916 3146 2306 3190 4091 3643 2644 712 2170 2713 M13484 GO_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 377/583 Gene Ontology BP GO:0052547 9.15524438152794e-08 4.02645553947883e-07 2900 2289.45454545455 2597 8.32294978411012e-09 324 2.2798564348454 2.43499804941544 1 17.5298833015736 2898 2340 324 2189 902 2597 3886 3027 2958 1174 2889 2714 M11222 GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. 28/31 Gene Ontology BP GO:1903392 4.94815253559702e-08 4.02645553947883e-07 3350 2417.27272727273 2598 4.49832058808083e-09 242 1.79162247681103 1.17828092283052 1 13.753789478084 3348 2061 2598 1595 242 2850 3528 1056 2426 3039 3847 2715 M11426 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. 75/88 Gene Ontology BP GO:1903363 2.06771380632683e-07 5.01881707920644e-07 3320 2746.18181818182 2599 1.8797400006046e-08 1790 1.35802695305577 1.51599051478901 1 10.2431378995023 3319 3191 3772 2599 1841 2509 2418 1790 2083 3911 2775 2716 M13272 GO_PROTEIN_AUTOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOUBIQUITINATION.html The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. 47/55 Gene Ontology BP GO:0051865 3.62553696615238e-06 4.61801902641857e-06 2375 2777.90909090909 2599 3.29594812813382e-07 1921 1.00642303311342 -1.05720270796886 -1 6.391281777382 2374 2880 3985 2141 3626 2095 1921 2938 2599 4049 1949 2717 M11325 GO_MATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING.html The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. 24/48 Gene Ontology BP GO:0007618 4.77710196253963e-06 5.95761335612353e-06 2680 2529.18181818182 2600 4.34282939601641e-07 914 2.43347280934038 2.46741994186633 1 15.2741901125184 2676 2600 2107 3694 3705 2256 2955 2246 1787 2881 914 2718 M16605 GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY.html Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex. 14/15 Gene Ontology BP GO:0051488 1.28054504955168e-07 4.17034908558357e-07 2915 2355.45454545455 2601 1.16413193098896e-08 842 1.54140349908219 2.02025158163533 1 11.7901209004475 2614 2220 2601 2932 1317 2169 842 2913 2914 2973 2415 2719 M11137 GO_POLYOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 19/24 Gene Ontology BP GO:0046174 3.2466803617686e-05 3.61493269282348e-05 1625 2467.54545454545 2602 2.95157116008369e-06 508 1.07955974166543 -1.14803267988899 -1 5.69646065975778 1622 3554 3671 2602 4155 1490 901 508 3821 4041 778 2720 M13765 GO_REGULATION_OF_GROWTH_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. 11/17 Gene Ontology BP GO:0060123 1.77009571038365e-06 2.42456736544454e-06 2400 2475.72727272727 2602 1.60917921325884e-07 457 1.21050694457276 -1.1738488273638 -1 8.11784713847397 2397 3375 3287 2989 3366 1985 1325 2602 457 4031 1419 2721 M11201 GO_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DETERMINATION.html Any process that establishes and transmits the specification of sexual status of an individual organism. 12/29 Gene Ontology BP GO:0007530 0.000140117495852856 0.000148850846621767 1785 2639.63636363636 2604 1.27387655181689e-05 1242 1.4362966869569 -1.48589106951014 -1 6.54517753490589 1784 3066 2832 2604 4353 1635 1242 3432 4276 1594 2218 2722 M16216 GO_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_MIGRATION.html The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. 21/26 Gene Ontology BP GO:0014812 2.56953463598947e-07 5.67073823596828e-07 2185 2590.09090909091 2604 2.33594085100321e-08 1593 1.68507985348125 1.63052221953221 1 12.6266942951438 2182 2630 2604 3899 2048 1843 1593 2691 4268 2072 2661 2723 M15291 GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of macrophage differentiation. 20/25 Gene Ontology BP GO:0045649 3.40102411403587e-08 3.99952679980378e-07 2605 2335.72727272727 2605 3.09184015146633e-09 88 2.20588126509265 -2.66297190532765 -1 16.9655200625255 2605 3304 1758 2972 88 3354 2919 1012 4139 1218 2324 2724 M16076 GO_POSITIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the cell cycle. 394/497 Gene Ontology BP GO:0045787 3.99395865393598e-07 7.56705814693271e-07 1945 2501.18181818182 2605 3.63087216273973e-08 1687 1.72454248440381 1.86871213217762 1 12.6635013950955 1943 3411 3219 2605 2406 1687 1953 2724 2990 2769 1806 2725 M16502 GO_CELLULAR_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 84/137 Gene Ontology BP GO:0035690 2.51269217899249e-07 5.61554116659561e-07 2790 2335.81818181818 2605 2.28426587815941e-08 235 2.08619359017951 2.15148584599699 1 15.6675583210542 2786 235 1853 1220 2021 2430 3518 2605 3010 3103 2913 2726 M10621 GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 54/68 Gene Ontology BP GO:0010718 1.72390729743149e-06 2.36827300116585e-06 2435 2544.90909090909 2607 1.56718968025162e-07 972 2.09141797194918 2.4278821139555 1 14.1261032385964 2432 2475 1049 1413 3356 3615 3630 3688 2757 972 2607 2727 M14747 GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein depolymerization. 23/30 Gene Ontology BP GO:1901881 4.81659252551093e-08 4.02645553947883e-07 3100 2580.72727272727 2607 4.37872057360317e-09 218 2.16160848252906 -1.92503824219854 -1 16.6153312614417 2918 2607 2310 2239 218 3097 4380 3055 1994 3100 2470 2728 M14938 GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase B. 27/37 Gene Ontology BP GO:0032148 5.86856084841046e-07 9.98406348360288e-07 2610 2582.72727272727 2607 5.33505673987808e-08 1465 2.91183396168908 -2.98359616612427 -1 21.0288669914952 2607 3259 1672 1664 2693 2827 2319 4480 2221 3203 1465 2729 M13307 GO_CELL_DIFFERENTIATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_HINDBRAIN.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. 23/41 Gene Ontology BP GO:0021533 4.24208443002818e-08 4.02645553947883e-07 3755 2285.36363636364 2608 3.85644046529538e-09 159 2.68125083410384 -2.41108629503009 -1 20.6343435442108 3755 879 790 903 159 4001 2772 4308 2608 650 4314 2730 M14154 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. 56/69 Gene Ontology BP GO:0060761 2.20863215821609e-06 2.94210290070984e-06 1930 2609.36363636364 2608 2.00784943228854e-07 425 2.06238696810154 -1.77487915546477 -1 13.6935664372033 1930 425 1855 3667 3461 2291 2040 3678 3517 2608 3231 2731 M12846 GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. 51/60 Gene Ontology BP GO:0042398 2.52185396094657e-08 3.44992641396772e-07 3100 2306 2609 2.29259453623137e-09 36 1.74737807443326 1.69980579168912 1 13.5534232430509 3099 413 2149 1708 36 3028 3104 4319 2609 1250 3651 2732 M14102 GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 58/103 Gene Ontology BP GO:0045912 5.16547128792132e-07 9.05270730798414e-07 2120 2464.18181818182 2609 4.69588409158559e-08 415 1.7257616566829 1.84851734827363 1 12.5100405647649 2120 415 2489 3232 2609 2562 2880 1424 3515 3020 2840 2733 M12375 GO_SYNAPTIC_VESICLE_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_ENDOCYTOSIS.html Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished. 20/27 Gene Ontology BP GO:0048488 1.16321034215304e-07 4.08548528935279e-07 3435 2099.63636363636 2610 1.05746400332335e-08 32 1.58541631625114 -1.27306097718257 -1 12.1468326284147 3431 967 2856 1377 1209 2628 1131 3183 32 3672 2610 2734 M11232 GO_REGULATION_OF_RUFFLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RUFFLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of ruffle assembly. 27/35 Gene Ontology BP GO:1900027 5.00933559261587e-07 8.86381301052373e-07 2800 2782.45454545455 2611 4.55394248475207e-08 777 1.52025011683557 1.62355006781006 1 11.0248649853414 2798 777 2515 2256 2581 3001 4171 4529 2611 2552 2816 2735 M14161 GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 164/262 Gene Ontology BP GO:0071241 5.22024870640349e-07 9.13838120048738e-07 3965 2701.72727272727 2612 4.7456817682596e-08 766 2.46386271753703 2.49700031844434 1 17.8923776496822 3962 2806 766 2222 2612 3384 4180 2550 2490 1117 3630 2736 M16434 GO_PROTEIN_O_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. 88/116 Gene Ontology BP GO:0006493 1.24993532778084e-07 4.14431426073273e-07 3675 2498.54545454545 2613 1.13630490799657e-08 187 2.28042963043106 2.24528120558201 1 17.499760075067 3672 187 1036 4096 1291 4351 3255 3230 2411 1342 2613 2737 M11365 GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 46/67 Gene Ontology BP GO:0032480 5.24478077110486e-07 9.17229913589221e-07 820 2176.09090909091 2614 4.76798365586948e-08 182 1.39162002981002 -1.26841812387802 -1 10.0583215736262 818 3694 3477 3962 2614 303 182 748 3946 3753 440 2738 M12714 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. 142/177 Gene Ontology BP GO:0017015 1.42403517809686e-07 4.2854237685504e-07 3150 2673 2614 1.29457751843006e-08 1223 2.28326202598502 2.64279157965915 1 17.4814700826081 3913 3148 1223 1358 1442 4304 3674 3147 2090 2614 2490 2739 M16456 GO_EMBRYONIC_PLACENTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_MORPHOGENESIS.html The process in which the embryonic placenta is generated and organized. 23/31 Gene Ontology BP GO:0060669 2.26476233865986e-06 3.00654469665744e-06 4510 2940.09090909091 2614 2.05887697281303e-07 1735 1.89281007209907 -1.72677547523812 -1 12.5376258998362 4507 2097 2328 2059 3472 4512 3797 2614 1735 2739 2481 2740 M11699 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT.html Any process that modulates the frequency, rate or extent of cellular response to heat. 92/95 Gene Ontology BP GO:1900034 5.24553793264758e-07 9.17229913589221e-07 890 2741.72727272727 2615 4.76867198487289e-08 655 1.15754073626912 1.15733772489177 1 8.34913009453605 886 4390 4106 4290 2615 969 655 1590 4341 4352 1965 2741 M13198 GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 21/28 Gene Ontology BP GO:0009218 1.19882933222022e-07 4.10861475461767e-07 2235 2707.18181818182 2615 1.08984490686102e-08 1239 1.08003551777585 1.20493932489545 1 8.23878269045377 2233 2615 3541 3462 1239 2292 1444 3404 3061 3945 2543 2742 M13980 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 142/177 Gene Ontology BP GO:1903844 1.42403517809686e-07 4.2854237685504e-07 3915 2670.81818181818 2615 1.29457751843006e-08 1224 2.28326202598502 2.64279157965915 1 17.4814700826081 3914 3149 1224 1359 1443 4305 3675 3113 2091 2615 2491 2743 M12280 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. 10/15 Gene Ontology BP GO:1901722 4.53685186461916e-07 8.29813403313878e-07 2830 2311.90909090909 2616 4.12441163655587e-08 463 2.24403009467413 3.02523206569897 1 16.4004673087674 2827 2739 2521 2769 2494 2616 2151 463 2853 2685 1313 2744 M13794 GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. 23/51 Gene Ontology BP GO:0045589 9.88208283919545e-06 1.16703886930905e-05 605 2615.36363636364 2616 8.98375202578734e-07 605 1.00441799103701 -0.973475298814214 -1 5.88925319120716 605 2070 3352 3009 3913 1250 2368 2616 4459 2732 2395 2745 M15790 GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT.html The progression of the atrioventricular valve over time, from its formation to the mature structure. 23/30 Gene Ontology BP GO:0003171 1.16720332399526e-06 1.68769330843689e-06 4100 2299.27272727273 2618 1.06109449386536e-07 652 2.69042949097321 -2.55658681970657 -1 18.6802645617236 4096 827 698 1086 3180 3911 2618 3159 989 652 4076 2746 M16147 GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS.html The process in which the structure of the atrioventricular valve is generated and organized. 23/26 Gene Ontology BP GO:0003181 1.16720332399526e-06 1.68769330843689e-06 4100 2298.18181818182 2619 1.06109449386536e-07 654 2.69042949097321 -2.55658681970657 -1 18.6802645617236 4097 828 699 1087 3181 3912 2619 3136 990 654 4077 2747 M16113 GO_MIDGUT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDGUT_DEVELOPMENT.html The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. 18/25 Gene Ontology BP GO:0007494 2.82832839441395e-07 5.99008284897957e-07 3050 2646 2620 2.5712079618409e-08 1081 2.02172866763912 1.86437596129727 1 15.1116749041871 3049 2654 1850 3000 2138 2415 1081 2620 3932 2343 4024 2748 M16967 GO_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 21/40 Gene Ontology BP GO:0071731 2.066455223513e-06 2.77976760769182e-06 2515 2375.63636363636 2620 1.87859742230223e-07 660 1.79947825380459 1.92962664336769 1 11.9884588351868 2515 2620 2659 2991 3430 1704 1145 660 4401 3173 834 2749 M13535 GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 384/474 Gene Ontology BP GO:0051348 1.66790727692346e-07 4.53963284590687e-07 2635 2762.72727272727 2621 1.51627945761285e-08 1131 1.74048279523469 2.01264577575312 1 13.2486029610418 2632 4116 3412 4049 1624 1131 2291 2434 2621 4202 1878 2750 M11739 GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT.html The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. 13/21 Gene Ontology BP GO:0060712 5.32549227722686e-07 9.28419466689268e-07 2825 2514.36363636364 2622 4.84135778759787e-08 814 2.06582947925249 1.55056590269277 1 14.9680823644063 2822 3064 2541 2595 2622 1720 814 2036 2763 3213 3468 2751 M16292 GO_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 308/463 Gene Ontology BP GO:0009416 1.6849599737961e-07 4.55820858027515e-07 2710 2355.72727272727 2622 1.53178191167788e-08 1256 1.85256336699141 1.87555731210901 1 14.1044200345779 2710 2778 2622 2074 1635 1256 3122 1833 2785 2944 2154 2752 M13382 GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. 17/19 Gene Ontology BP GO:0007095 2.14679280985847e-07 5.12148364863292e-07 2195 2569.72727272727 2623 1.95163001758704e-08 1205 1.53701561102039 1.89309565835568 1 11.5904110634292 2195 3796 3316 3013 1878 2617 2821 1205 2623 3376 1427 2753 M13567 GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. 9/12 Gene Ontology BP GO:0008655 1.67036833969861e-05 1.90916823498345e-05 3030 2375.90909090909 2623 1.67038089541819e-06 633 1.52681372195829 1.71437896177248 1 8.61107880254938 3028 1264 4437 4312 4065 2623 787 633 961 3028 997 2754 M13960 GO_ANDROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 23/68 Gene Ontology BP GO:0008209 1.88398989701095e-05 2.14018676533007e-05 1290 2649.90909090909 2624 1.71273275538387e-06 1091 2.14999015242002 -2.67799692853776 -1 12.0387661558464 1288 3281 2341 3753 4072 1767 1091 2560 3639 2733 2624 2755 M14337 GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE.html Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. 9/12 Gene Ontology BP GO:0043097 1.67036833969861e-05 1.90916823498345e-05 3030 2392.45454545455 2624 1.67038089541819e-06 754 1.52681372195829 1.71437896177248 1 8.61107880254938 3029 1265 4488 4313 4066 2624 788 754 962 3030 998 2756 M14173 GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 17/18 Gene Ontology BP GO:0070498 5.35318012718161e-07 9.31915358967056e-07 1000 2066.63636363636 2625 4.86652857250176e-08 246 1.67474227657484 -1.87238026122418 -1 12.1116411305491 999 3327 3195 3010 2625 629 246 429 3770 3698 805 2757 M11731 GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 65/100 Gene Ontology BP GO:0032370 5.35355631747032e-07 9.31915358967056e-07 3810 2473.72727272727 2626 4.86687056383975e-08 314 2.47689563178616 3.2562639940605 1 17.962082509604 3808 314 995 1129 2626 4307 3383 3546 2843 1639 2621 2758 M14674 GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. 189/234 Gene Ontology BP GO:1901796 9.46337885879461e-07 1.43198214268385e-06 1010 2430.09090909091 2626 8.60307539045763e-08 719 1.44670660669403 1.63464294703574 1 10.1220657961536 1008 3644 3921 2626 3037 719 918 1964 2893 4283 1718 2759 M14790 GO_PEPTIDYL_PROLINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_MODIFICATION.html The modification of peptidyl-proline. 47/55 Gene Ontology BP GO:0018208 2.95077810629767e-05 3.29255887976092e-05 810 2402.18181818182 2626 2.68256153157199e-06 563 1.57855886117246 1.73113085468978 1 8.45454082381837 810 3491 3185 4105 4148 1224 1464 563 2626 3620 1188 2760 M10869 GO_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WOUNDING.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. 566/807 Gene Ontology BP GO:0009611 2.41705257670252e-10 5.73803348948817e-09 3720 2359.81818181818 2627 2.41705257696541e-11 115 2.29642913720843 2.48241216099365 1 22.7853907250085 3718 1422 4267 379 480 3748 3807 2627 1968 115 3427 2761 M14911 GO_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of neuron death. 312/401 Gene Ontology BP GO:1901214 2.08126506325156e-07 5.03496702824436e-07 2990 2590.81818181818 2627 1.89205932740493e-08 1459 1.77911838038521 -1.53357119972651 -1 13.4482106823338 2989 2347 2627 1459 1848 2762 1898 4122 2429 2661 3357 2762 M12185 GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. 20/33 Gene Ontology BP GO:1903409 3.27535357632769e-07 6.64641089867106e-07 2630 2633.09090909091 2629 2.97759460360135e-08 1802 1.59593753489405 -1.74505121073624 -1 11.8202063593921 2629 2642 2806 2990 2237 2478 1802 2303 4366 1918 2793 2763 M14587 GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 15/26 Gene Ontology BP GO:0032924 2.1299630909305e-07 5.11172703648005e-07 3175 2309.72727272727 2629 1.93633027013283e-08 592 1.58532205518815 -1.61997455264099 -1 11.9595065339151 3171 3348 2629 1813 1866 2902 1559 592 2865 2675 1987 2764 M11200 GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. 21/26 Gene Ontology BP GO:2000251 4.71750687038812e-07 8.49151236669862e-07 4655 2715.81818181818 2630 4.2886435290668e-08 804 2.38276076275929 2.40046810213894 1 17.3919135134497 4651 939 1634 804 2536 4022 4289 2630 1260 2831 4278 2765 M13769 GO_MICROGLIAL_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROGLIAL_CELL_ACTIVATION.html The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 25/50 Gene Ontology BP GO:0001774 6.69515454333264e-07 1.09432305313226e-06 2860 2128.18181818182 2631 6.08650598257982e-08 482 2.7655513456062 -2.82596648168304 -1 19.8340167052069 2856 2965 1401 1386 2801 3798 2811 884 482 2631 1395 2766 M10829 GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an alpha-amino acid. 200/255 Gene Ontology BP GO:1901605 3.58720921443414e-07 7.02790925253139e-07 1685 2672.90909090909 2632 3.26109981758776e-08 1681 1.76365047486417 1.61642839192823 1 13.0214801968905 2796 1683 2632 3364 2319 2251 2776 3667 2610 1681 3623 2767 M16344 GO_FOLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 20/20 Gene Ontology BP GO:0046655 6.71577783784733e-06 8.11860594427218e-06 1995 2570.54545454545 2632 6.1052712169954e-07 312 2.55802150852066 2.20937792116794 1 15.6453982455621 1995 2632 2112 2859 3821 2322 2539 3340 312 2654 3690 2768 M10502 GO_FOCAL_ADHESION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOCAL_ADHESION_ASSEMBLY.html The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. 38/40 Gene Ontology BP GO:0048041 8.7729616473616e-08 4.02645553947883e-07 2840 2290.27272727273 2635 7.97541999745627e-09 638 1.98164300376015 2.093349938664 1 15.2234441924705 2839 638 2199 1761 856 3991 3567 2960 957 2635 2790 2769 M14304 GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction. 38/40 Gene Ontology BP GO:0007045 8.7729616473616e-08 4.02645553947883e-07 2840 2314.09090909091 2636 7.97541999745627e-09 639 1.98164300376015 2.093349938664 1 15.2234441924705 2840 639 2200 1762 857 3992 3568 3212 958 2636 2791 2770 M10222 GO_SULFUR_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 324/421 Gene Ontology BP GO:0006790 1.23837406877643e-07 4.14338946095474e-07 3830 2655.45454545455 2637 1.12579467134925e-08 824 1.92339352705306 2.0943825665932 1 14.7440110817355 3828 1542 1135 2637 1277 3693 4579 3622 2108 824 3965 2771 M11729 GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. 84/110 Gene Ontology BP GO:0033238 4.17824624063572e-07 7.84794997995146e-07 1445 2690.90909090909 2637 3.79840639469967e-08 1441 1.43247813099367 1.49468430787851 1 10.4739816883035 1441 2846 3516 3801 2430 2220 2102 2637 1635 4000 2972 2772 M11766 GO_SPERM_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MOTILITY.html Any process involved in the controlled movement of a sperm cell. 65/121 Gene Ontology BP GO:0030317 1.53045180560344e-07 4.39183276674602e-07 2730 2558.63636363636 2638 1.3913199200644e-08 1416 2.33358626031094 2.5509166688859 1 17.8389771630547 2730 2857 1416 3672 1527 2638 2568 3242 2177 2709 2609 2773 M14814 GO_FEMALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GAMETE_GENERATION.html Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. 99/155 Gene Ontology BP GO:0007292 5.41368283089048e-07 9.38154741747064e-07 3465 2594.45454545455 2638 4.9215310573373e-08 1086 2.24915343628604 2.45516891588877 1 16.293180078909 3463 1841 1086 1513 2638 3220 3925 3251 2537 1560 3505 2774 M10749 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. 24/29 Gene Ontology BP GO:0051150 6.8900366009093e-07 1.1166611042853e-06 1610 2590.45454545455 2640 6.26367159886901e-08 1303 2.70739328988253 2.66438343289801 1 19.3860180056893 1606 3748 1936 3263 2826 1549 1303 4200 2640 3184 2240 2775 M14013 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of organic acid across a membrane. 80/133 Gene Ontology BP GO:1903825 1.67534831805753e-07 4.54807218431838e-07 3440 2486.54545454545 2640 1.52304404149e-08 211 2.2674727332656 2.34069857507186 1 17.2890268578635 3436 211 858 2640 1629 3836 4347 4509 1032 1161 3693 2776 M14668 GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. 243/297 Gene Ontology BP GO:2001234 1.08748025298791e-07 4.02645553947883e-07 2315 2544 2641 9.88618460675518e-09 1128 1.81176682907129 1.95952126191264 1 13.9095897105267 2312 2783 2203 3803 1128 1374 2934 3655 3300 1851 2641 2777 M10618 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. 20/24 Gene Ontology BP GO:1901032 3.74337124975516e-07 7.22434940900488e-07 2865 2717.36363636364 2642 3.40306535154732e-08 744 2.15021859562001 1.99815988780814 1 15.8670435703747 2861 988 2216 2495 2360 3085 3702 4173 744 2642 4625 2778 M11941 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. 498/657 Gene Ontology BP GO:1902532 1.09870013135566e-07 4.02645553947883e-07 4270 3121.18181818182 2642 9.98818351114319e-09 1144 1.81536416630742 2.09207311215212 1 13.9374121974611 4270 2333 2575 2554 1144 3826 4298 3780 2642 2476 4435 2779 M15003 GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 68/87 Gene Ontology BP GO:0030148 5.11623777562118e-07 8.97706679137555e-07 4365 2708.27272727273 2642 4.65112633221336e-08 282 1.98112688823148 -2.02764235665053 -1 14.3851481751888 4361 282 1795 2642 2605 3488 3777 4294 1219 1287 4041 2780 M11510 GO_NEGATIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. 11/18 Gene Ontology BP GO:0046851 6.45923809986942e-05 7.00089328644128e-05 2645 2864.18181818182 2643 5.87220704728564e-06 1229 2.5406541827778 2.52297506264963 1 12.663474704104 2643 1229 1906 4130 4263 3433 2594 2612 3383 2378 2935 2781 M13557 GO_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAT_CASCADE.html An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with activation of STAT proteins by kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 46/85 Gene Ontology BP GO:0097696 9.68989715478505e-07 1.45536124794109e-06 2155 2517.90909090909 2643 8.80900129336511e-08 1654 1.74655119545501 -1.67653211193115 -1 12.2264493830811 2155 1946 2772 3057 3061 2383 1654 1776 3088 3162 2643 2782 M13999 GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION.html The modification of peptidyl-glutamic acid. 24/35 Gene Ontology BP GO:0018200 5.43443296641743e-07 9.39700311675655e-07 3295 2593.18181818182 2643 4.9403948262089e-08 185 2.79657340507584 -3.95137463491611 -1 20.2814073554934 3292 2599 1986 1914 2643 3337 3723 3498 185 2887 2461 2783 M12109 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 19/21 Gene Ontology BP GO:0060213 2.21321289504106e-07 5.1753788816965e-07 1630 2714 2644 2.01201192517419e-08 863 0.872836605827679 -0.945101445014102 -1 6.5326442884863 1628 3791 3751 4521 1920 1067 863 2644 4594 4042 1033 2784 M12394 GO_PROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. 1185/1551 Gene Ontology BP GO:0070271 1.10741237782283e-07 4.02645553947883e-07 3085 2831.36363636364 2644 1.10741243300913e-08 1255 1.84814724020395 1.9525767097398 1 14.1909626947557 3083 2319 4367 2644 1255 2342 2982 4067 2028 2286 3772 2785 M14003 GO_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE.html Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 46/85 Gene Ontology BP GO:0007259 9.68989715478505e-07 1.45536124794109e-06 2160 2527.27272727273 2644 8.80900129336511e-08 1655 1.74655119545501 -1.67653211193115 -1 12.2264493830811 2156 1947 2773 3058 3062 2384 1655 1869 3089 3163 2644 2786 M16814 GO_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex. 1185/1551 Gene Ontology BP GO:0006461 1.10741237782283e-07 4.02645553947883e-07 3085 2858.09090909091 2645 1.10741243300913e-08 1256 1.84814724020395 1.9525767097398 1 14.1909626947557 3084 2320 4647 2645 1256 2343 2983 4072 2029 2287 3773 2787 M16342 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM.html Any process that modulates the frequency, rate or extent of defense response to bacterium. 9/15 Gene Ontology BP GO:1900424 4.9670097888202e-07 8.82455003718228e-07 1250 2739.27272727273 2646 4.96701089902393e-08 1248 1.96520430461616 -2.07551656809015 -1 14.2863925434771 1248 3388 4615 2111 2646 1296 1419 4155 4009 3035 2210 2788 M16484 GO_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 114/170 Gene Ontology BP GO:0046165 6.81670205401588e-07 1.10902498801874e-06 1075 2435 2647 6.1970037874296e-08 1073 1.8432108302802 -1.8287338249336 -1 13.171905814006 1073 3163 2647 3437 2815 1955 1579 1748 3476 2743 2149 2789 M12604 GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER.html The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. 18/41 Gene Ontology BP GO:0060795 4.80152971777406e-07 8.59828085247675e-07 4570 3088.36363636364 2648 4.36502796883157e-08 1499 1.92699264502171 1.95211594969633 1 14.0328945884691 4567 2648 2459 2033 2549 4482 4440 1499 1832 3152 4311 2790 M11151 GO_POSITIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. 468/658 Gene Ontology BP GO:0043410 1.76136955414905e-08 2.70483582028235e-07 3955 2409.09090909091 2651 1.60124506204634e-09 198 2.17609919454535 -1.9965991471499 -1 17.1821274061887 3952 1468 210 774 1201 4252 3352 4617 2651 198 3825 2791 M11711 GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 14/17 Gene Ontology BP GO:0009214 2.16388086085543e-07 5.13962042198191e-07 3630 2724.63636363636 2651 1.9671646124463e-08 694 2.16907029888076 1.61895488185587 1 16.3949546200478 3628 2208 1711 2651 1887 3688 4151 3219 694 1566 4568 2792 M10854 GO_LUNG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_CELL_DIFFERENTIATION.html The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. 24/33 Gene Ontology BP GO:0060479 4.74300431514832e-06 5.92143790673065e-06 2785 2617.18181818182 2652 4.31183140061328e-07 917 1.85512030937446 -1.60258415141631 -1 11.625507333075 2785 917 2652 1644 3702 3467 3660 3289 2122 2508 2043 2793 M11747 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion. 7/14 Gene Ontology BP GO:2000484 9.95993400251069e-07 1.48680054262696e-06 2135 2680.18181818182 2652 9.95993846652635e-08 1277 1.64284231894374 1.57489967874097 1 11.4758968546716 2131 1277 4322 1420 3155 2811 3480 3504 2652 2526 2204 2794 M12223 GO_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 76/79 Gene Ontology BP GO:0032204 6.30782628874994e-05 6.84475646491452e-05 1155 2724.72727272727 2652 5.73455195782931e-06 716 1.31038014381089 1.22275863927708 1 6.49704299726767 1152 4161 4009 3642 4257 1193 716 2652 1366 4492 2332 2795 M13643 GO_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 105/151 Gene Ontology BP GO:0007219 6.11676531554401e-07 1.02859808504612e-06 3375 2643.18181818182 2652 5.56069728747111e-08 1285 2.19044944726223 -1.66902358260541 -1 15.7593442320718 3373 2404 1285 1997 2725 3177 2652 4334 1335 2175 3618 2796 M14628 GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that modulates the frequency, rate or extent of lamellipodium organization. 68/81 Gene Ontology BP GO:1902743 1.20852801941558e-07 4.11483088288319e-07 3580 2340 2652 1.09866189618524e-08 301 1.98904130944069 -1.63573712876496 -1 15.2579820409515 3576 301 2006 1419 1250 3170 4485 3398 758 2725 2652 2797 M12704 GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 35/39 Gene Ontology BP GO:0042558 1.93360333368732e-07 4.91108508790997e-07 1805 2579.90909090909 2653 1.75782136693981e-08 700 1.86998163099096 1.62739950994276 1 14.1647649555898 1805 700 2653 3864 1750 2630 3178 3817 1099 2911 3972 2798 M16813 GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS.html The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. 228/356 Gene Ontology BP GO:0045137 2.01987007307934e-07 4.97676750327016e-07 3440 2717.18181818182 2653 1.83624568957112e-08 1286 2.07177863586003 1.99376219542607 1 15.6899934507152 3437 2365 1286 2011 1812 2852 3642 3588 2653 1666 4577 2799 M12186 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. 20/35 Gene Ontology BP GO:0051770 6.59434466405261e-06 7.98633152572535e-06 2105 2770.18181818182 2654 5.9948767547437e-07 1265 1.96642090621775 -1.8398498246875 -1 12.020199315065 2103 3302 2436 3274 3816 1956 1265 2654 4125 2646 2895 2800 M12512 GO_NITROGEN_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_COMPOUND_TRANSPORT.html The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 449/690 Gene Ontology BP GO:0071705 1.74359299881075e-07 4.64658546590288e-07 3265 2832.18181818182 2656 1.58508466999808e-08 1666 1.87749414855465 -1.89790168001702 -1 14.2766786250129 3264 2338 2470 3363 1666 4220 3709 2621 1850 2997 2656 2801 M13261 GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of B cell mediated immunity. 33/54 Gene Ontology BP GO:0002712 9.15260078334061e-07 1.39675472105227e-06 990 2225.81818181818 2656 8.32054962824971e-08 473 1.82339757302925 -1.74247824002376 -1 12.8082945528853 986 3967 2796 3712 3011 1249 663 1097 3874 2656 473 2802 M14281 GO_MESODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. 30/48 Gene Ontology BP GO:0048333 7.40777322283621e-08 4.02645553947883e-07 2000 2678.72727272727 2658 6.73433952024409e-09 632 1.93180261622232 2.42308968849372 1 14.8379692035951 2000 3246 2205 3270 632 2658 3473 3433 3675 2311 2563 2803 M14397 GO_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 254/323 Gene Ontology BP GO:0006732 1.24494623732938e-07 4.14338946095474e-07 1320 2712.90909090909 2658 1.13176937070817e-08 1284 1.55999437209061 -1.63158224902049 -1 11.9388774108414 1317 3126 3816 4303 1284 2582 2933 1407 2658 3929 2487 2804 M14612 GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. 81/143 Gene Ontology BP GO:0002688 1.81019207245654e-08 2.76158154529189e-07 4240 2296 2659 1.64562917031914e-09 193 2.70948758501233 2.72591684984209 1 21.3893649002165 4237 193 212 705 472 3890 4406 3692 2659 318 4472 2805 M13483 GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. 359/405 Gene Ontology BP GO:0007264 4.722094984793e-08 4.02645553947883e-07 4045 2784.18181818182 2660 4.29281371468034e-09 209 1.71514773983002 1.86049380837618 1 13.1623193904039 4043 1528 2660 2367 209 3871 3171 4488 1903 2602 3784 2806 M14328 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. 124/154 Gene Ontology BP GO:0048660 1.52536263710427e-07 4.38697565224918e-07 4555 2715.81818181818 2660 1.38669340260435e-08 802 2.1558600783129 2.30181686627406 1 16.4737704430233 4555 2397 1094 1861 1521 4615 3767 3082 2660 802 3520 2807 M16416 GO_LEUKOTRIENE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_METABOLIC_PROCESS.html The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 29/54 Gene Ontology BP GO:0006691 1.75256315731789e-07 4.65466347597117e-07 4305 2720.72727272727 2661 1.59323936084594e-08 718 1.95830821037915 -1.88382490367283 -1 14.8938429953102 4303 718 1650 1959 1671 3658 2661 3898 3773 1042 4595 2808 M12239 GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. 18/18 Gene Ontology BP GO:0042982 2.50548888311034e-05 2.81323353598272e-05 1850 2710.72727272727 2662 2.27774310685499e-06 1029 1.69519542795472 -1.56331812711472 -1 9.22692051435263 1849 1029 2662 4150 4120 2017 1815 2699 4173 2760 2544 2809 M11600 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 49/67 Gene Ontology BP GO:0043268 5.61829035742198e-07 9.66206452566504e-07 4420 2466.81818181818 2663 5.10753799291245e-08 473 2.30621894035816 -2.1155023267567 -1 16.6734945123347 4419 473 1096 1516 2663 3464 4452 2760 1475 1093 3724 2810 M11275 GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper cell differentiation. 15/40 Gene Ontology BP GO:0045622 1.61384833668022e-06 2.23339308753343e-06 850 2638 2664 1.46713592777092e-07 849 2.21736617160544 -2.39884496653897 -1 15.0512909481466 849 3354 2701 3506 3331 2111 2179 2406 3824 2664 2093 2811 M11770 GO_POSITIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BINDING.html Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 54/70 Gene Ontology BP GO:0043388 5.66132233022094e-07 9.73111666143999e-07 1780 2633.27272727273 2664 5.14665798824143e-08 1175 1.39930295966951 -1.4008357943514 -1 10.0709543367831 1779 3206 3452 2349 2664 1846 1175 2564 3909 3305 2717 2812 M16497 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 692/874 Gene Ontology BP GO:0031400 8.56328850884484e-08 4.02645553947883e-07 3000 2614.72727272727 2664 8.56328883882946e-09 932 1.77944755746193 1.98262462916847 1 13.6596263478898 2998 2328 4626 2763 932 1507 3529 2664 2150 3791 1474 2813 M12293 GO_ANDROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 10/34 Gene Ontology BP GO:0006702 9.99647501595317e-06 1.17905192013258e-05 1090 2425 2665 9.0877458534072e-07 343 2.16060519184911 -2.43353553658959 -1 12.7752753773646 1086 3096 2665 3298 3918 1185 343 1838 4242 2686 2318 2814 M11334 GO_TISSUE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. 198/311 Gene Ontology BP GO:0001894 5.38686968560415e-08 4.02645553947883e-07 2860 2222.45454545455 2667 4.89715437955075e-09 231 2.3186272809414 2.44869133479123 1 17.8297443621684 2858 1682 231 1283 705 2667 4242 3584 3325 554 3316 2815 M12988 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 61/84 Gene Ontology BP GO:0046364 4.49136089641383e-06 5.62538418600634e-06 1820 2599.27272727273 2667 4.08306369607057e-07 926 1.60792818869195 -1.8226320341114 -1 10.1060226596546 1818 3200 3366 2973 3690 2402 2139 926 2667 3411 2000 2816 M10492 GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that stops or reduces the activity of a transporter. 64/102 Gene Ontology BP GO:0032410 6.45524660230261e-08 4.02645553947883e-07 4165 2518.09090909091 2669 5.86840617428425e-09 313 1.69878197340142 -1.77400482246224 -1 13.0357434558325 4164 313 2669 2110 474 3558 2884 2996 2220 2190 4121 2817 M12758 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of cellular response to hypoxia. 15/15 Gene Ontology BP GO:1900037 3.96109656065494e-05 4.37271228866606e-05 1680 2433.54545454545 2669 3.60106171084944e-06 643 1.82217818043705 2.05489072227177 1 9.50368268148852 1677 3361 2973 3036 4182 1574 643 1616 2851 2669 2187 2818 M11670 GO_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_PRODUCTION.html The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 20/37 Gene Ontology BP GO:0032612 1.26988666196873e-05 1.47645743081972e-05 1120 2544 2671 1.15444908371193e-06 795 2.03512246365963 -1.75891194083735 -1 11.7869020064825 1116 3782 2671 3592 3974 1462 997 795 4129 3670 1796 2819 M14081 GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). 14/24 Gene Ontology BP GO:0007191 1.27920977728449e-06 1.82469745361886e-06 3370 2719.09090909091 2672 1.1629186555392e-07 1168 2.36659711966619 2.87472538011567 1 16.3224107240941 3370 2672 1551 1775 3227 4043 3375 4600 2085 2044 1168 2820 M12220 GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. 16/20 Gene Ontology BP GO:1902991 4.28222505288241e-06 5.38518734353023e-06 3520 2516 2673 3.89293944373664e-07 65 2.21136706145429 -1.82246824008979 -1 13.9880317339603 3518 2673 2624 1162 3675 4508 4291 1100 65 2864 1196 2821 M11060 GO_3_UTR_MEDIATED_MRNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_UTR_MEDIATED_MRNA_STABILIZATION.html An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. 16/16 Gene Ontology BP GO:0070935 3.84203033454784e-07 7.37233164478964e-07 2245 2671.90909090909 2674 3.49275545955592e-08 764 1.50919464885334 1.32970823941576 1 11.0899879029282 2243 2674 3149 3898 2375 1140 764 4402 2604 3232 2910 2822 M13269 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 17/18 Gene Ontology BP GO:0010801 5.75473736177588e-07 9.85165303323883e-07 2610 2863.27272727273 2675 5.23158078826791e-08 1772 1.06769352018666 1.13383960773035 1 7.65301789953319 1772 3022 3643 2607 2675 2263 2610 2720 4259 3697 2228 2823 M16499 GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. 11/16 Gene Ontology BP GO:0002903 2.1609943928083e-07 5.13962042198191e-07 2560 2857.63636363636 2675 1.96454055006942e-08 1793 1.6900690280918 1.97930382264329 1 12.7516789648961 2560 3073 2675 4121 1884 3445 3489 1947 4057 2390 1793 2824 M10955 GO_GLUTAMATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. 23/33 Gene Ontology BP GO:0006536 5.76318983402677e-07 9.86082286769201e-07 3035 2492.45454545455 2677 5.23926485797348e-08 895 2.27190129429599 1.99025183485428 1 16.3995549202289 3031 895 1721 3664 2677 2192 1739 2813 3398 2355 2932 2825 M11478 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. 40/48 Gene Ontology BP GO:1902883 8.53053746473559e-08 4.02645553947883e-07 2680 2497.45454545455 2677 7.75503435955334e-09 813 1.70498540162724 1.66755510732592 1 13.0837219436506 2677 1976 2807 1446 813 2576 3195 3948 1066 2876 4092 2826 M15695 GO_REGULATION_OF_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_COHESION.html Any process that modulates the frequency, rate or extent of sister chromatid cohesion. 20/21 Gene Ontology BP GO:0007063 1.09014392693953e-05 1.2780145356638e-05 1680 2515.45454545455 2677 9.9104484441621e-07 229 1.90957308806124 2.1079056132134 1 11.1981680502575 1680 2988 2677 1586 3947 2889 2589 2668 229 3678 2739 2827 M14848 GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING.html Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 14/17 Gene Ontology BP GO:0090036 3.78933144602746e-06 4.80939746046367e-06 4085 2527.45454545455 2678 3.44485270261481e-07 1139 2.56248152784408 -2.15029517075204 -1 16.3775535087976 4084 1139 1262 1970 3642 4149 3044 1435 3188 1211 2678 2828 M15700 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. 40/48 Gene Ontology BP GO:1900408 8.53053746473559e-08 4.02645553947883e-07 2680 2505.18181818182 2678 7.75503435955334e-09 814 1.70498540162724 1.66755510732592 1 13.0837219436506 2678 1977 2808 1447 814 2577 3196 4023 1067 2877 4093 2829 M16612 GO_REGULATION_OF_GONADOTROPIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GONADOTROPIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. 6/14 Gene Ontology BP GO:0032276 4.07126340336352e-06 5.13098283202884e-06 4250 2722.45454545455 2678 4.07127086221632e-07 867 3.22065311014787 3.64102518330012 1 20.5010718589851 4246 2746 4640 936 3688 4219 2678 867 2447 2251 1229 2830 M10182 GO_CYTOKINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 10/19 Gene Ontology BP GO:0042107 6.15974254210251e-06 7.51278690652765e-06 3420 2607.45454545455 2681 5.59978162611671e-07 513 2.13973009352536 2.56027364384922 1 13.157361627893 3419 3080 2212 2720 3787 4519 2011 513 1964 2681 1776 2831 M11953 GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. 19/21 Gene Ontology BP GO:0051560 4.87698197395117e-08 4.02645553947883e-07 3635 2499.54545454545 2681 4.43362007460419e-09 230 1.87971886347135 1.55014886881054 1 14.4351436036329 3633 2143 2681 2686 230 2177 2673 4371 349 2917 3635 2832 M12974 GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 31/43 Gene Ontology BP GO:0071377 8.48877945428543e-08 4.02645553947883e-07 2345 2540.90909090909 2681 7.7170725289346e-09 750 1.86455503270957 2.07021960711205 1 14.3178636669596 3085 750 2075 2681 802 3692 3696 3733 2342 2750 2344 2833 M13099 GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 17/22 Gene Ontology BP GO:0009068 3.95019889937725e-07 7.51442170024625e-07 3700 2800.27272727273 2684 3.59109055332127e-08 779 1.71684324255699 1.24896562643991 1 12.6127998335584 3696 2187 2699 2684 2396 3233 4407 2343 779 2181 4198 2834 M13853 GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. 15/23 Gene Ontology BP GO:0048642 5.74644134326396e-06 7.05865669752038e-06 3020 2433.09090909091 2685 5.22405123011966e-07 1451 2.4836218875663 2.26321722325938 1 15.369862133828 2855 3019 1638 2685 3762 2053 1451 1560 3017 1782 2942 2835 M15543 GO_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. 162/196 Gene Ontology BP GO:0006643 1.09468136618576e-07 4.02645553947883e-07 2685 2450.90909090909 2685 9.95164927868351e-09 1139 1.67190534726008 -1.72932160124565 -1 12.8278745431965 2685 1749 3209 3141 1139 2751 3035 2426 1648 2263 2914 2836 M11721 GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 75/133 Gene Ontology BP GO:0045913 3.52026526613799e-07 6.95537638350604e-07 2510 2670.72727272727 2687 3.20024166311183e-08 1891 1.89373016438056 -1.83577471791091 -1 13.999804232001 2510 3190 2704 2131 2298 2687 3148 2272 3686 2861 1891 2837 M13010 GO_LEUKOCYTE_TETHERING_OR_ROLLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_TETHERING_OR_ROLLING.html Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). 15/17 Gene Ontology BP GO:0050901 1.90587410939037e-06 2.58467858670749e-06 1950 2932.54545454545 2687 1.73261432769394e-07 1240 2.83334057500882 3.25366485942372 1 19.0436830441574 1948 2687 1240 4310 3399 2594 3414 3166 4293 2671 2536 2838 M13338 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleotide across a membrane. 13/13 Gene Ontology BP GO:1901679 4.25652981761215e-07 7.95406957483909e-07 2360 2660.54545454545 2687 3.86957331014538e-08 923 1.33275539354271 -1.32933839752595 -1 9.72826027728694 2359 2705 3164 4306 2442 2697 2687 923 3466 2298 2219 2839 M12418 GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of mast cell degranulation. 10/16 Gene Ontology BP GO:0043306 6.32851440011422e-06 7.69040937679067e-06 4430 2773.81818181818 2688 5.75321145888723e-07 971 2.18210688691322 -2.22326986492735 -1 13.3931968325994 4426 3602 2625 1834 3800 3531 1279 1363 971 2688 4393 2840 M14170 GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL.html The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. 15/17 Gene Ontology BP GO:0061756 1.90587410939037e-06 2.58467858670749e-06 1950 2934.36363636364 2688 1.73261432769394e-07 1241 2.83334057500882 3.25366485942372 1 19.0436830441574 1949 2688 1241 4311 3400 2595 3415 3176 4294 2672 2537 2841 M13436 GO_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 127/188 Gene Ontology BP GO:0070555 4.69230412180374e-07 8.46908110114539e-07 2005 2921.36363636364 2689 4.26573192964492e-08 1944 1.85304733782046 -1.95817823150235 -1 13.5051893103857 2004 3898 2689 4047 2528 2441 1944 3126 4002 2539 2917 2842 M15875 GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE.html Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 11/17 Gene Ontology BP GO:0010984 8.84097459769631e-06 1.05156070560023e-05 2075 2746.90909090909 2691 8.03728193314193e-07 788 3.01434626677745 3.01434626677745 1 18.0451559709638 2072 4307 2691 3924 3886 2942 2521 788 1704 3752 1629 2843 M11635 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 30/31 Gene Ontology BP GO:1902230 5.79087081407422e-07 9.88804473316968e-07 3740 2685.45454545455 2692 5.26442939850538e-08 1095 2.25585469823517 2.18954375245038 1 16.279730123121 3740 3248 2223 2692 2683 2602 2633 2705 1095 2951 2968 2844 M12939 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. 10/16 Gene Ontology BP GO:0033008 6.32851440011422e-06 7.69040937679067e-06 4430 2791.45454545455 2692 5.75321145888723e-07 972 2.18210688691322 -2.22326986492735 -1 13.3931968325994 4427 3603 2626 1835 3801 3532 1280 1544 972 2692 4394 2845 M15690 GO_REGULATION_OF_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H4_ACETYLATION.html Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. 14/16 Gene Ontology BP GO:0090239 1.88094760408837e-05 2.13725255233778e-05 2540 2686.18181818182 2692 1.70996698721355e-06 184 1.24944175212588 0.767823527199541 1 6.95396409415051 2537 2692 3317 1662 4071 2156 914 3927 184 3977 4111 2846 M10477 GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of ERBB signaling pathway. 98/115 Gene Ontology BP GO:1901184 9.10028583862592e-08 4.02645553947883e-07 2645 2398.54545454545 2693 8.27298746823516e-09 135 1.57026856313296 -1.42256950226981 -1 12.0417964212918 2642 135 3308 3023 894 2845 2445 2693 1718 3770 2911 2847 M10548 GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 26/33 Gene Ontology BP GO:0009261 7.67340849553629e-07 1.21392848553279e-06 2425 2573.54545454545 2694 6.97582833814153e-08 1437 1.9151753246886 1.61746118052759 1 13.5992811508276 2423 2953 2103 4102 2896 1868 2238 2722 2694 1437 2873 2848 M11051 GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type peptidase activity. 4/15 Gene Ontology BP GO:1902571 1.69998704742764e-07 4.57756928916714e-07 680 1990.72727272727 2694 1.69998717747567e-08 11 2.69055400195233 -2.69055400195233 -1 20.5250119446644 679 2754 4276 2694 3933 549 268 32 3597 3105 11 2849 M10815 GO_PROTEIN_LOCALIZATION_TO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CILIUM.html A process in which a protein is transported to, or maintained in, a location within a cilium. 29/32 Gene Ontology BP GO:0061512 5.88536899760721e-07 1.00053423258554e-06 2650 2603.27272727273 2695 5.3503368836752e-08 1263 1.49166489514376 1.59675868313973 1 10.7207171114929 2649 2938 3382 3903 2695 1425 1263 2356 2735 3842 1448 2850 M11683 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. 4/12 Gene Ontology BP GO:1902572 1.61351345104372e-07 4.4655132638076e-07 680 1995.18181818182 2695 1.61351356819789e-08 12 2.69055400195233 -2.69055400195233 -1 20.5600359635071 680 2755 4320 2695 3934 550 269 27 3598 3107 12 2851 M16243 GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that activates or increases the rate of ATP hydrolysis by an ATPase. 63/76 Gene Ontology BP GO:0032781 4.0453852151646e-07 7.64835319459027e-07 2695 2691.27272727273 2695 3.67762359912261e-08 1635 1.9617998868821 1.9943852905248 1 14.4088618147786 2695 3680 2900 2277 2412 1896 2654 3899 2788 2768 1635 2852 M10997 GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that activates or increases the frequency, rate, or extent of cellular extravasation. 10/16 Gene Ontology BP GO:0002693 1.24544401046541e-06 1.78474006180953e-06 3105 2660.36363636364 2696 1.13222246865947e-07 1779 2.54243464883111 2.19396209773861 1 17.5723782672003 3102 2281 1844 3701 3207 3470 2766 2277 1779 2141 2696 2853 M13174 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. 4/12 Gene Ontology BP GO:1900004 1.78170809783286e-07 4.70237537108128e-07 685 2005.09090909091 2696 1.78170824068464e-08 13 2.69055400195233 -2.69055400195233 -1 20.4869981189255 681 2756 4414 2696 3935 551 270 33 3599 3108 13 2854 M10250 GO_FATTY_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 76/95 Gene Ontology BP GO:0009062 4.80269330229681e-07 8.59828085247675e-07 1445 2721.63636363636 2697 4.36608577340495e-08 1050 1.51376284353372 -1.31690428538004 -1 11.001562065667 1442 2849 3584 3930 2550 2427 2913 1050 2697 3841 2655 2855 M13264 GO_NEUTRAL_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. 14/30 Gene Ontology BP GO:0046461 1.2664059188866e-06 1.80865154713915e-06 2485 2746.90909090909 2697 1.1512787707999e-07 2040 1.91039900076386 -2.02664186736303 -1 13.1650301725944 2483 2697 2115 3409 3221 2881 2346 3233 3747 2040 2044 2856 M15052 GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. 4/15 Gene Ontology BP GO:1900003 1.60354028770503e-07 4.46344808647544e-07 685 2016.27272727273 2697 1.6035404034154e-08 14 2.69055400195233 -2.69055400195233 -1 20.5606896679612 682 2757 4534 2697 3936 552 271 26 3600 3110 14 2857 M10568 GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 55/97 Gene Ontology BP GO:0032890 1.75071554864741e-07 4.65466347597117e-07 3430 2634 2698 1.59155971633258e-08 412 2.25011608625689 2.42064754300622 1 17.1285191109687 3429 412 963 2698 1668 3542 4558 4179 3718 1365 2442 2858 M11141 GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. 30/52 Gene Ontology BP GO:0050869 2.67222899944732e-05 2.99323099047385e-05 1280 2904.27272727273 2698 2.42932859837879e-06 1277 2.00662479066897 -2.18007127967952 -1 10.8755753400577 1277 4466 2564 4359 4130 2301 1314 1555 4334 2949 2698 2859 M13407 GO_REGULATION_OF_FEVER_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEVER_GENERATION.html Any process that modulates the rate or extent of fever generation. 9/13 Gene Ontology BP GO:0031620 4.75774922559146e-06 5.93825298998848e-06 2170 3084.27272727273 2698 4.75775941190211e-07 1619 2.6970226890156 -3.16224267481183 -1 16.9441763019375 2168 4313 4425 3917 3736 2698 1858 1619 4596 2458 2139 2860 M14211 GO_ACYLGLYCEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 14/30 Gene Ontology BP GO:0046464 1.2664059188866e-06 1.80865154713915e-06 2045 2747 2698 1.1512787707999e-07 2045 1.91039900076386 -2.02664186736303 -1 13.1650301725944 2484 2698 2116 3410 3222 2882 2347 3220 3748 2045 2045 2861 M11547 GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 625/771 Gene Ontology BP GO:0010638 1.53932090792244e-07 4.40145422830765e-07 2680 2941.63636363636 2699 1.53932101455035e-08 1641 1.71044685873355 1.8332980285952 1 13.0459619530889 2679 3113 4309 3321 1641 2452 3164 2635 2328 4017 2699 2862 M11273 GO_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_PROCESS.html A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. 14/21 Gene Ontology BP GO:0003016 5.94714629709788e-06 7.28020829265889e-06 3920 2414.63636363636 2700 5.40651124888358e-07 234 2.61760046762023 -1.41135973806379 -1 16.1620514233307 3916 2700 1746 2710 3771 4562 2932 234 1016 1563 1411 2863 M16937 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. 220/261 Gene Ontology BP GO:1903322 4.73447822590881e-07 8.51218206536077e-07 2700 2978.72727272727 2700 4.30407204071424e-08 1686 1.3744028644041 1.43052772953244 1 9.98652317851819 2700 3132 3986 1686 2539 2345 2662 3228 2563 4223 3702 2864 M11686 GO_REGULATION_OF_PROTEIN_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_GLYCOSYLATION.html Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. 14/16 Gene Ontology BP GO:0060049 2.05204793535869e-05 2.32202797743774e-05 955 2551.90909090909 2703 1.86551552369682e-06 601 0.919992429342298 -0.961124446509687 -1 5.05314675451334 951 2703 3628 4183 4089 1558 907 1033 4253 4165 601 2865 M13832 GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM.html A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. 232/471 Gene Ontology BP GO:0022412 1.24085122807971e-07 4.14338946095474e-07 2355 2652.09090909091 2706 1.12804663460601e-08 1280 1.77722964410004 1.80299500772558 1 13.6157497086938 2355 3421 2676 2731 1280 2706 2789 3544 2579 2193 2899 2866 M13953 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. 38/41 Gene Ontology BP GO:1904358 5.57619822982761e-06 6.86948646105053e-06 1565 2515.45454545455 2706 5.06928396682553e-07 296 1.45426191895898 1.29724868820261 1 8.97775910823263 1565 3710 3481 2624 3751 1389 885 2928 296 4335 2706 2867 M12623 GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 57/98 Gene Ontology BP GO:0071384 2.44906565422693e-06 3.22453381129539e-06 2340 2642.09090909091 2707 2.22642580050875e-07 807 2.13682763378761 2.09708516145501 1 14.0886664569993 2339 3471 1659 4488 3500 1127 807 3669 3247 2707 2049 2868 M11006 GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. 14/18 Gene Ontology BP GO:0009208 2.2612035081183e-07 5.25330762845858e-07 2340 2795.54545454545 2708 2.05563976411755e-08 1936 0.894190462710293 0.99031982923837 1 6.6879643735432 2336 2219 3602 3482 1936 2708 1984 2270 3268 4163 2783 2869 M15329 GO_NUCLEOSIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSPORT.html The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/20 Gene Ontology BP GO:0015858 1.98154034463811e-07 4.93246485651519e-07 2885 2713.18181818182 2708 1.80140047555955e-08 1278 2.13189552925525 1.79937545954188 1 16.158270706878 2881 2233 2546 3408 1790 3266 3842 2528 1278 3365 2708 2870 M12468 GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 13/24 Gene Ontology BP GO:0010758 2.65693300415638e-07 5.75100736858827e-07 4010 2960.09090909091 2709 2.41539393184854e-08 1211 2.61594191494142 -2.84243062904768 -1 19.6394227123898 4009 2709 1211 2476 2088 4366 4511 1733 3798 1378 4282 2871 M14104 GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. 14/18 Gene Ontology BP GO:0042754 4.11711105899452e-07 7.74956219963653e-07 2710 2807 2709 3.74282893588791e-08 1658 1.2572270557292 -1.52484078816935 -1 9.18831719061732 2709 2695 3272 3918 2422 2847 1821 1658 4087 2493 2955 2872 M13782 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. 19/24 Gene Ontology BP GO:1901018 1.80855746842483e-06 2.46852974496354e-06 2940 2539.54545454545 2710 1.64414450471839e-07 1003 2.12939284803195 2.30635097465175 1 14.3380950275154 2937 1003 1865 2682 3379 2710 3097 3608 1307 2115 3232 2873 M11993 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 23/33 Gene Ontology BP GO:0044253 0.000425405437533843 0.000442722321817261 2330 2806.27272727273 2711 3.86807017093675e-05 1045 1.81199792013689 2.00253509986561 1 7.24679522581315 2329 2980 2615 3291 4447 2711 3156 1045 4072 2357 1866 2874 M13627 GO_ORGAN_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_INDUCTION.html The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. 12/25 Gene Ontology BP GO:0001759 1.5579546703806e-06 2.1633545685206e-06 3275 2482.09090909091 2711 1.41632343060433e-07 935 1.86200093391393 2.34690314974131 1 12.653762345416 3273 2711 2430 1223 3318 3521 2994 1621 935 3499 1778 2875 M13991 GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that stops or reduces the activity of an enzyme. 818/1178 Gene Ontology BP GO:0043086 8.65092761384039e-08 4.02645553947883e-07 3215 2521.54545454545 2711 8.65092795061387e-09 946 2.01634945402749 2.22355735539006 1 15.4918704465914 3214 1383 4463 2369 946 1978 3773 2930 2711 1192 2778 2876 M14646 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that stops, prevents, or reduces the rate of leukocyte degranulation. 7/18 Gene Ontology BP GO:0043301 1.18007536356673e-06 1.70260102401526e-06 2720 2372.27272727273 2711 1.18007599022724e-07 67 2.33540802756843 -2.87276972151469 -1 16.190896139698 2716 2304 4507 1544 3236 2968 1573 1304 67 3165 2711 2877 M16187 GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. 23/33 Gene Ontology BP GO:0010714 0.000425405437533843 0.000442722321817261 2330 2806.54545454545 2712 3.86807017093675e-05 1036 1.81199792013689 2.00253509986561 1 7.24679522581315 2330 2981 2616 3292 4448 2712 3157 1036 4073 2360 1867 2878 M12491 GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 28/41 Gene Ontology BP GO:0035710 3.98789733013804e-06 5.03409828462623e-06 770 2494.27272727273 2714 3.62536778085503e-07 767 1.50795150031144 -1.64702273574816 -1 9.55921403279001 767 2945 3294 3535 3660 1658 1222 1338 4042 2714 2262 2879 M13610 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. 196/249 Gene Ontology BP GO:0048872 1.7320837637862e-07 4.62385872225886e-07 2715 2669.45454545455 2714 1.57462172741367e-08 1662 1.65163554158721 -1.5057380621881 -1 12.551091921306 2714 1705 2958 3236 1662 2665 1826 2842 2672 2998 4086 2880 M12790 GO_PROSTAGLANDIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. 28/44 Gene Ontology BP GO:0006693 2.61360522886029e-07 5.70140887477118e-07 2430 2718.72727272727 2715 2.37600503577933e-08 1524 2.43719117465268 -2.65406128197812 -1 18.3014878128055 2426 2943 2038 4114 2071 2461 1524 3530 3164 2715 2920 2881 M14846 GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. 14/22 Gene Ontology BP GO:0032682 1.58123569335633e-07 4.44738738572283e-07 4050 2653.36363636364 2715 1.43748709727876e-08 1172 1.7851418747357 -2.34039605536867 -1 13.6104395638028 4050 2228 2519 2715 1566 3420 3654 1827 3067 2969 1172 2882 M15509 GO_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. 221/300 Gene Ontology BP GO:0030099 1.53442782022479e-07 4.39394452489232e-07 2305 2570.90909090909 2715 1.39493447931464e-08 1530 1.70851419606641 -1.55509563456121 -1 13.0326371574063 2304 2787 2715 3259 1530 1686 1691 2603 3717 2771 3217 2883 M13365 GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. 33/65 Gene Ontology BP GO:0046637 6.03907040135541e-07 1.01884679396326e-06 1500 2741.09090909091 2716 5.49006550827291e-08 1496 1.83074701708613 -1.9407905990239 -1 13.1636917761917 1496 2919 3119 3567 2716 2226 2817 2364 3865 2366 2697 2884 M11115 GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 186/228 Gene Ontology BP GO:0044272 9.72144775844199e-08 4.02645553947883e-07 3080 2545.72727272727 2717 8.83768017092479e-09 932 2.04355401751106 2.24612362877914 1 15.7022756886901 3079 1706 1021 3646 973 3286 4519 2667 2717 932 3457 2885 M10530 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 97/150 Gene Ontology BP GO:0071347 6.04357213654932e-07 1.01886743302043e-06 2360 2895.09090909091 2718 5.49415799706046e-08 1959 1.95335135684137 -2.04891926235258 -1 14.0521328050137 2358 3666 2347 3601 2718 2467 1959 3041 3838 2506 3345 2886 M11738 GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. 186/242 Gene Ontology BP GO:0043409 8.67121472234427e-08 4.02645553947883e-07 4415 2930.54545454545 2718 7.88292278556077e-09 844 1.69367263534651 1.94415090897065 1 12.9962268684387 4413 1703 2718 1656 844 4640 3638 3326 2067 2641 4590 2887 M15959 GO_PROSTANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. 28/44 Gene Ontology BP GO:0006692 2.61360522886029e-07 5.70140887477118e-07 2430 2703.72727272727 2718 2.37600503577933e-08 1525 2.43719117465268 -2.65406128197812 -1 18.3014878128055 2427 2944 2039 4115 2072 2462 1525 3353 3165 2718 2921 2888 M10525 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 143/187 Gene Ontology BP GO:0014066 2.03881516462666e-07 4.99381053281994e-07 4445 2724.54545454545 2719 1.85346850324605e-08 596 2.14463923119926 2.24599168193809 1 16.2415512077096 4444 1773 596 942 1823 4556 3770 4133 2719 878 4336 2889 M12244 GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE.html Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. 12/12 Gene Ontology BP GO:0048875 2.67515723666589e-06 3.49452740657114e-06 4250 2768.54545454545 2719 2.43196408146421e-07 1457 2.53043662192329 2.11495764051003 1 16.5959286663343 4249 2719 1457 1975 3532 4628 2808 2258 3648 1596 1584 2890 M11327 GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. 138/198 Gene Ontology BP GO:0098780 1.04516787828632e-07 4.02645553947883e-07 3730 2643.72727272727 2720 9.50152661763435e-09 1069 2.31675868369838 2.51989223725582 1 17.8152922774827 3730 1810 1379 2180 1069 3550 3306 3705 1171 2720 4461 2891 M13888 GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION.html The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential. 138/198 Gene Ontology BP GO:0098779 1.04516787828632e-07 4.02645553947883e-07 3735 2659.63636363636 2721 9.50152661763435e-09 1070 2.31675868369838 2.51989223725582 1 17.8152922774827 3731 1811 1380 2181 1070 3551 3307 3870 1172 2721 4462 2892 M11039 GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of vasculature development. 141/200 Gene Ontology BP GO:1904018 3.15183848254365e-07 6.45393277958822e-07 2705 2581.36363636364 2722 2.86530812190281e-08 741 2.2520368239297 2.26450740638794 1 16.7566498538543 2703 2819 741 1606 2212 2722 3900 3908 3059 813 3912 2893 M13966 GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of T cell proliferation. 66/104 Gene Ontology BP GO:0042130 6.10212553314517e-07 1.02725000382505e-06 2445 2959.09090909091 2722 5.54738838698943e-08 1874 1.6410007465337 -1.6770212622833 -1 11.7816011009637 2444 1874 2444 2964 2722 3014 4573 4516 2977 2345 2677 2894 M15648 GO_MACROMITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMITOPHAGY.html Degradation of a mitochondrion by macroautophagy. 138/198 Gene Ontology BP GO:0000423 1.04516787828632e-07 4.02645553947883e-07 3735 2653.45454545455 2722 9.50152661763435e-09 1071 2.31675868369838 2.51989223725582 1 17.8152922774827 3732 1812 1381 2182 1071 3552 3308 3792 1173 2722 4463 2895 M11098 GO_RESPONSE_TO_TYPE_I_INTERFERON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TYPE_I_INTERFERON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 76/123 Gene Ontology BP GO:0034340 6.95851754680563e-06 8.39242668358906e-06 240 2579.27272727273 2724 6.32594505130299e-07 238 1.44382352990293 -1.5132100178847 -1 8.76072812459161 238 3456 3363 3488 3831 1247 1347 2292 4020 2724 2366 2896 M11401 GO_CLATHRIN_COAT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_ASSEMBLY.html The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. 11/13 Gene Ontology BP GO:0048268 3.83567895022122e-06 4.86173090585109e-06 1090 2339.36363636364 2725 3.48698694337008e-07 781 1.3835106816039 -1.02369609388878 -1 8.78717877217018 1088 2269 3158 2725 3645 1240 781 3133 1185 3747 2762 2897 M11576 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. 9/16 Gene Ontology BP GO:1904406 2.26210926780958e-06 3.00387968696289e-06 4560 2972.90909090909 2725 2.26211157052513e-07 277 2.04028195223982 -1.57154956283332 -1 13.5234244413039 4556 1225 4312 2703 3507 4397 2725 2125 277 2450 4425 2898 M13023 GO_VITAMIN_D_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). 11/25 Gene Ontology BP GO:0042359 3.92275927125677e-06 4.9599453503146e-06 3495 2281.72727272727 2725 3.56615115076182e-07 466 4.30978287622236 3.06082701868246 1 27.5454894910432 3493 2725 1101 1616 3653 3256 2867 1163 466 1862 2897 2899 M14870 GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 24/24 Gene Ontology BP GO:0090312 2.79342498050846e-06 3.6332025808006e-06 3345 2802 2725 2.53948047948579e-07 468 1.85858473115748 2.39230247005306 1 12.1242460556822 3345 2605 2725 2335 3549 3134 3988 2369 468 3744 2560 2900 M15814 GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 33/56 Gene Ontology BP GO:0007215 2.50146721762403e-06 3.28516143483054e-06 4325 2780.81818181818 2725 2.27406369261201e-07 1018 2.4003612837284 2.13262853825085 1 15.8154262713144 4323 1997 1126 2378 3511 3279 4618 4465 1149 1018 2725 2901 M12164 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 9/16 Gene Ontology BP GO:0045019 2.26210926780958e-06 3.00387968696289e-06 4560 2984.90909090909 2726 2.26211157052513e-07 278 2.04028195223982 -1.57154956283332 -1 13.5234244413039 4557 1226 4350 2704 3508 4398 2726 2207 278 2454 4426 2902 M12215 GO_MEMBRANE_TUBULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_TUBULATION.html A modification in a plasma membrane resulting in formation of a tubular invagination. 11/14 Gene Ontology BP GO:0097320 6.01225823165938e-06 7.3521780688334e-06 965 1993.81818181818 2727 5.46570423844545e-07 108 1.61672981562088 -1.48795267748511 -1 9.93457849595349 962 2727 3175 2921 3775 999 108 673 2773 3339 480 2903 M13310 GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. 10/35 Gene Ontology BP GO:0002579 2.1795159626991e-08 3.19914440834036e-07 3990 2496.09090909091 2728 1.98137816753758e-09 17 1.97342102786673 -1.45865732396093 -1 15.3982541229594 3988 2728 1974 1770 17 4429 4202 3033 681 1618 3017 2904 M15080 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes outside the context of DNA replication. 44/63 Gene Ontology BP GO:0006336 7.29923991565945e-06 8.77833117796935e-06 3215 1873.81818181818 2728 6.63569466677753e-07 27 1.75910081036722 1.85391550714708 1 10.6546897500763 27 3212 2875 2874 3842 157 54 752 3214 2728 877 2905 M16465 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures, occurring outside the context of DNA replication. 44/63 Gene Ontology BP GO:0034724 7.29923991565945e-06 8.77833117796935e-06 3215 1875.18181818182 2730 6.63569466677753e-07 28 1.75910081036722 1.85391550714708 1 10.6546897500763 28 3213 2876 2875 3843 158 55 756 3215 2730 878 2906 M11304 GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 70/82 Gene Ontology BP GO:0033143 4.44839318660238e-07 8.18764774416964e-07 2910 2675.63636363636 2731 4.04399462369668e-08 1669 1.53815860673968 -1.56101834990458 -1 11.2200570357569 2907 2854 3414 1669 2478 3132 2731 2527 2020 3577 2123 2907 M12075 GO_COFACTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. 23/37 Gene Ontology BP GO:0051187 2.11210647917175e-05 2.38824579528218e-05 3355 2888.18181818182 2731 1.92011523335341e-06 1498 1.7682752979134 -0.94440180869509 -1 9.78123950092725 3353 2082 2439 2914 4093 3932 4005 1498 2155 2731 2568 2908 M13246 GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 131/165 Gene Ontology BP GO:0072522 1.73158189781174e-07 4.62385872225886e-07 1240 2771 2731 1.57416548554688e-08 1237 1.45784673939246 1.46703483436796 1 11.0663738485104 1237 3437 3649 4476 1661 2014 2188 2420 2731 3928 2740 2909 M12052 GO_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. 78/117 Gene Ontology BP GO:0030183 3.52609333473112e-07 6.95966502114418e-07 2825 2460.18181818182 2732 3.20553990898437e-08 671 2.35566453952812 -2.33172590751426 -1 17.4391043048701 2824 3186 1304 1993 2301 3446 2732 3756 671 1310 3539 2910 M14157 GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 594/883 Gene Ontology BP GO:0071345 2.85075016517906e-07 6.02112597302685e-07 1825 2792.54545454545 2732 2.85075053088406e-08 764 2.01827679562665 -1.8974400355418 -1 15.0802181122666 1825 3626 4476 3749 2206 2372 2025 3310 3633 764 2732 2911 M11554 GO_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_ENGULFMENT.html The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. 30/159 Gene Ontology BP GO:0006911 9.43513852939423e-08 4.02645553947883e-07 3795 2636.81818181818 2733 8.57739903094451e-09 933 2.89287058264372 -2.60298041843864 -1 22.2710507257576 3791 2021 1169 1966 933 4513 3720 2733 2878 1677 3604 2912 M16798 GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. 75/83 Gene Ontology BP GO:0007266 6.20685307877235e-07 1.0407382838028e-06 4475 2636.27272727273 2733 5.64259529991869e-08 259 2.00985251178167 2.43162999350922 1 14.4391516779858 4471 259 1617 2258 2733 3545 2674 4005 2736 879 3822 2913 M10379 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 21/25 Gene Ontology BP GO:1900153 2.46003270914406e-07 5.54848870365842e-07 1900 2790.72727272727 2734 2.23639362202195e-08 1033 0.955745245177516 -0.945101445014102 -1 7.12799901150662 1900 4012 3674 4523 1999 1258 1033 2734 4556 3940 1069 2914 M10993 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte migration. 19/39 Gene Ontology BP GO:2000403 6.51704393970197e-07 1.07990760154677e-06 2915 2376.63636363636 2734 5.92458715476539e-08 985 3.31633558434301 -2.80889612123162 -1 23.8277409656214 2912 1034 985 3691 2764 3020 2300 1326 2734 1722 3655 2915 M15290 GO_RESPONSE_TO_EPINEPHRINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPINEPHRINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 23/29 Gene Ontology BP GO:0071871 1.47616701008868e-08 2.35226201984336e-07 4455 2583.90909090909 2735 1.34197001817594e-09 4 1.73403233344721 1.49593666935886 1 13.7979255464388 4453 882 2484 1201 4 4400 3609 3570 581 2735 4504 2916 M16625 GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that modulates the frequency, rate or extent of viral release from host cell. 39/50 Gene Ontology BP GO:1902186 6.22091549949779e-07 1.0419697559094e-06 1230 2582.81818181818 2736 5.65537932598167e-08 1226 1.60786010733209 -1.52779487866056 -1 11.5295726285212 1226 2894 2953 4123 2736 2016 1356 2255 3374 3515 1963 2917 M10769 GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein. 144/160 Gene Ontology BP GO:0042787 1.39178637102789e-07 4.25357343137389e-07 2055 2765 2737 1.26526041734228e-08 1419 1.42268370429095 1.6488618328483 1 10.8593437708396 1604 3651 3976 3618 1419 2271 2815 2052 2737 4219 2053 2918 M12473 GO_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BUDDING.html The evagination of a membrane, resulting in formation of a vesicle. 153/170 Gene Ontology BP GO:0006900 1.80443443398904e-07 4.72066258868601e-07 4250 2725 2738 1.64039507453483e-08 1017 1.53400579368755 -1.11583552550996 -1 11.633174430894 1017 3433 3708 4250 1695 1517 1163 3646 2561 4247 2738 2919 M15627 GO_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 21/45 Gene Ontology BP GO:0050704 4.7025378106036e-07 8.47768633581501e-07 3895 3066.63636363636 2738 4.27503528707222e-08 1694 2.48412030275539 -3.22820664989558 -1 18.1382486989153 3895 2621 1727 2738 2532 4153 4512 2034 3790 1694 4037 2920 M14057 GO_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION.html The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. 30/73 Gene Ontology BP GO:0030101 4.88184560506775e-07 8.69648836155446e-07 2950 2630.18181818182 2742 4.43804244396341e-08 1520 1.87072438693047 -1.75898480967976 -1 13.6089681016052 2948 2916 2359 2911 2566 2742 1520 3889 1928 2001 3152 2921 M13412 GO_CARDIOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. 14/19 Gene Ontology BP GO:0010002 8.24452235499827e-07 1.28644408175074e-06 4150 2899.18181818182 2743 7.49502313149366e-08 634 2.20777364781751 -1.67951709955622 -1 15.6254136830493 4149 2684 1724 2072 2938 4536 3745 2743 634 2042 4624 2922 M16772 GO_MALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DIFFERENTIATION.html The establishment of the sex of a male organism by physical differentiation. 163/273 Gene Ontology BP GO:0046661 2.54504265904488e-07 5.65745344301423e-07 2570 2742.45454545455 2743 2.31367541224093e-08 1804 1.89776650648311 1.6467212052839 1 14.235737683276 2569 3429 2283 2424 2031 2743 3014 4095 1804 2746 3029 2923 M13418 GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 7/19 Gene Ontology BP GO:0001963 1.65238503087997e-06 2.2801149314011e-06 3615 2469.27272727273 2744 1.65238625955058e-07 443 2.87979872316671 4.03392999101677 1 19.5472685109629 3611 2744 4426 1166 3386 3232 3250 1051 443 1912 1941 2924 M13850 GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. 8/14 Gene Ontology BP GO:0090192 1.14509489854328e-06 1.66244198531104e-06 600 1976.36363636364 2745 1.14509548860276e-07 96 3.36062236413096 3.36062236413096 1 23.385822608468 596 3608 4454 2745 3258 400 464 96 3079 2819 221 2925 M13705 GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 20/23 Gene Ontology BP GO:0035728 1.65414704360544e-07 4.52287618430271e-07 2920 2792.90909090909 2746 1.50377015270753e-08 1612 2.3746636998663 -2.14571725114292 -1 18.1181326515783 2917 3301 2343 2328 1612 3486 3705 2746 2519 3674 2091 2926 M14209 GO_NEGATIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_T_CELL_SELECTION.html The process of elimination of immature T cells which react strongly with self-antigens. 10/20 Gene Ontology BP GO:0043383 9.4826732871909e-06 1.12214849453966e-05 2465 2606 2746 8.62064923696499e-07 1023 1.87552706289952 1.69516303639439 1 11.1248023883783 2463 3085 2746 3011 3905 1234 1023 3031 3337 2155 2676 2927 M11962 GO_RESPONSE_TO_NERVE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NERVE_GROWTH_FACTOR.html A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. 50/59 Gene Ontology BP GO:1990089 4.09981370588545e-07 7.72951101032618e-07 2185 3007.54545454545 2747 3.72710406355194e-08 1278 1.32279119240671 -1.18544970429746 -1 9.67465529191816 2183 4175 3669 3615 2418 2580 1278 2747 3723 4128 2567 2928 M12811 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. 5/15 Gene Ontology BP GO:0048934 3.81618010072946e-06 4.839652768791e-06 2750 2541.63636363636 2747 3.81618665419905e-07 216 2.17590779248332 2.70371073819414 1 13.8841508218564 1919 2749 4389 2747 3671 2641 3246 1261 216 3315 1804 2929 M10947 GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 248/324 Gene Ontology BP GO:0031668 5.31197557349213e-07 9.26757493193059e-07 4520 2765 2748 4.82906986917028e-08 505 2.36471672781557 2.56651870626821 1 17.1508079949561 4520 2781 505 1356 2621 3970 2748 4105 1931 1405 4473 2930 M11353 GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cell junction assembly. 116/135 Gene Ontology BP GO:1901888 7.12650822575974e-08 4.02645553947883e-07 2835 2465.63636363636 2748 6.4786440514639e-09 586 2.1199649143674 2.16926149890824 1 16.293252024765 2831 1823 979 1192 586 2767 4491 4216 2748 1282 4207 2931 M14140 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 5/15 Gene Ontology BP GO:0048935 3.81618010072946e-06 4.839652768791e-06 2750 2551.36363636364 2748 3.81618665419905e-07 217 2.17590779248332 2.70371073819414 1 13.8841508218564 1920 2750 4475 2748 3672 2642 3247 1273 217 3316 1805 2932 M14061 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. 61/86 Gene Ontology BP GO:0032106 3.7987518994927e-07 7.30998609067291e-07 3120 2818.18181818182 2749 3.4534114140231e-08 928 1.41270402104134 -1.5556613847041 -1 10.3806664908988 3120 2470 3573 2135 2368 2749 4029 3723 2684 3221 928 2933 M14701 GO_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGING.html An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). 91/113 Gene Ontology BP GO:0007569 1.3167142268058e-06 1.8707393274282e-06 2985 2354.36363636364 2749 1.1970136498804e-07 237 2.10140525321258 2.19315735122925 1 14.4543419982786 2985 2428 2148 237 3243 3342 4136 725 303 3602 2749 2934 M14664 GO_CELLULAR_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 97/139 Gene Ontology BP GO:1901655 8.00917950313857e-07 1.2585853504932e-06 2750 2689.45454545455 2750 7.28107492628254e-08 2127 2.06480449001274 2.35914919701516 1 14.6306326536138 2750 3177 2127 2329 2916 2705 3071 2305 2764 2889 2551 2935 M16372 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. 61/86 Gene Ontology BP GO:0032109 3.7987518994927e-07 7.30998609067291e-07 3125 2843.36363636364 2750 3.4534114140231e-08 929 1.41270402104134 -1.5556613847041 -1 10.3806664908988 3121 2471 3574 2136 2369 2750 4030 3990 2685 3222 929 2936 M10897 GO_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 45/54 Gene Ontology BP GO:0090311 2.18467562132994e-07 5.15590364235942e-07 3205 2479.90909090909 2751 1.98606894388706e-08 509 1.68555647886593 2.01033921015261 1 12.7145561989331 3201 555 3111 1666 1902 3379 4149 2348 509 3708 2751 2937 M16809 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. 21/36 Gene Ontology BP GO:0010575 6.36420444845206e-07 1.06024501606328e-06 4640 2771.36363636364 2751 5.78564208136611e-08 948 2.27144350838007 1.74502522635441 1 16.3097157350219 4640 2112 1355 948 2751 4407 3840 3704 2037 1078 3613 2938 M11129 GO_REGULATION_OF_NOREPINEPHRINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOREPINEPHRINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. 10/23 Gene Ontology BP GO:0014061 6.36973439119327e-07 1.06078647538376e-06 4545 2926.81818181818 2752 5.79066930494978e-08 533 3.59317877534489 3.81691531532178 1 25.859158929504 4541 3598 1852 2691 2752 4002 1708 4040 533 2683 3795 2939 M13571 GO_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_HOST.html An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 149/213 Gene Ontology BP GO:0051701 1.77370458483125e-07 4.68656867303793e-07 2855 2573.81818181818 2752 1.61245884348412e-08 1681 2.02204810194731 -2.13610259463226 -1 15.3747106367116 2851 3891 2795 2879 1681 2725 1727 2268 2752 3001 1742 2940 M16621 GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. 17/24 Gene Ontology BP GO:0043011 2.76535582155024e-06 3.59921696158693e-06 2705 2862.63636363636 2753 2.51396299777554e-07 1632 1.54350338954407 -1.40962815104664 -1 10.0590171090492 2704 2656 2664 2767 3547 2753 1632 4362 2532 3017 2855 2941 M13554 GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. 104/118 Gene Ontology BP GO:0048013 4.60841362956761e-07 8.38270078904538e-07 4045 2775 2755 4.18946781355247e-08 892 1.75859483683956 -1.24176618520895 -1 12.821031771355 4044 1838 2755 2779 2508 3471 2281 1808 892 3664 4485 2942 M14995 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. 42/54 Gene Ontology BP GO:0030837 9.68537449671207e-07 1.45536124794109e-06 3105 2482.81818181818 2755 8.80488978240508e-08 287 2.28366724439456 2.21140511917864 1 16.0181060426694 3104 515 1409 1093 3059 2755 4444 4087 287 1988 4570 2943 M12781 GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 469/577 Gene Ontology BP GO:0009896 1.0806071136252e-07 4.02645553947883e-07 2495 2905.72727272727 2756 9.8237015154819e-09 1115 1.50596109999282 -1.39766009000581 -1 11.5444303319985 2492 3405 4072 3627 1115 2404 2756 3320 2668 4358 1746 2944 M13400 GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT.html Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. 21/37 Gene Ontology BP GO:0060632 6.16176624203593e-06 7.51328572436928e-06 2275 2693.72727272727 2756 5.6016213636327e-07 1628 1.82540171337008 -1.52269538321409 -1 11.2093444715146 2275 3282 2946 2756 3788 2240 1628 1851 3132 3445 2288 2945 M14244 GO_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 41/61 Gene Ontology BP GO:0009268 7.74469785009348e-06 9.27092335901337e-06 3840 2946.63636363636 2758 7.04065919456448e-07 1961 2.27917331974225 -2.44678608179789 -1 13.7697960232627 3836 3217 2192 1961 3862 3237 2580 4094 2758 2703 1973 2946 M10463 GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. 18/22 Gene Ontology BP GO:0033599 2.50275569164776e-08 3.44536160746657e-07 4090 2628.18181818182 2759 2.27523247283592e-09 35 1.6849237264964 2.15600206911825 1 13.0664920506266 4090 2186 2642 2759 35 4546 3837 423 1350 3142 3900 2947 M12568 GO_NOSE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOSE_DEVELOPMENT.html The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). 18/29 Gene Ontology BP GO:0043584 2.66046934980249e-06 3.47827026823011e-06 2880 2543.90909090909 2761 2.41861142465893e-07 1008 1.85443421663148 1.70709907431227 1 12.1393876643448 2879 1008 2045 2071 3529 1993 1308 3929 3282 2761 3178 2948 M12140 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. 133/160 Gene Ontology BP GO:2001237 1.17415030576309e-07 4.08625383150012e-07 1220 2608.09090909091 2763 1.06740942584368e-08 1048 2.04675090846618 2.28876695817696 1 15.711152881432 2534 2393 1216 2796 1219 2763 4559 3749 3514 1048 2898 2949 M13395 GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 18/24 Gene Ontology BP GO:0071872 2.30225055328173e-08 3.26596701964021e-07 4050 2693.72727272727 2763 2.09295507034024e-09 26 1.92125396218493 1.58855360084421 1 14.967621291679 4049 2159 2338 1191 26 4150 4273 4056 249 2763 4377 2950 M14462 GO_CELLULAR_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 19/28 Gene Ontology BP GO:0071467 0.000322705721760268 0.000337426904123714 2755 2826.72727272727 2764 2.93411879440603e-05 444 1.60999210369509 -1.82277483604493 -1 6.65709352235324 2751 3306 3393 2764 4428 2134 1977 4090 444 3836 1971 2951 M11765 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 18/20 Gene Ontology BP GO:0034383 6.67329753315422e-07 1.09257049337673e-06 1760 2675.45454545455 2766 6.06663596125255e-08 1757 2.21515734021917 2.32035012153744 1 15.8680682663262 1757 3309 2171 2792 2797 2421 2392 2879 3387 2759 2766 2952 M15635 GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. 18/22 Gene Ontology BP GO:0000097 1.29577040903446e-06 1.84441789602204e-06 1130 2634.36363636364 2766 1.17797379293312e-07 1130 1.69271698080201 1.73143126300218 1 11.6357881523554 1130 3556 3094 3221 3234 2100 2436 1852 3346 2766 2243 2953 M16042 GO_MULTICELLULAR_ORGANISM_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_REPRODUCTION.html The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. 683/1283 Gene Ontology BP GO:0032504 1.29977934089216e-07 4.18739690741189e-07 2770 2796.63636363636 2766 1.29977941691635e-08 1159 1.97008657073224 2.03253849126578 1 15.0935094964516 2766 3404 4588 4100 1454 2275 2948 2428 2562 1159 3079 2954 M10549 GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION.html Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. 14/14 Gene Ontology BP GO:1901970 6.54615375602771e-07 1.08207080423379e-06 2790 2465 2768 5.95105063986597e-08 690 1.94195379480939 1.99304800589242 1 13.9081520728452 2787 3034 2706 2052 2768 2366 690 3576 723 3353 3060 2955 M16343 GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 34/55 Gene Ontology BP GO:0010862 1.0070167231086e-06 1.49796956925329e-06 1330 2525 2768 9.15470167323242e-08 1308 2.21078551167109 2.35610232480877 1 15.4701054032649 2930 1982 1326 1308 3087 2347 3051 4347 2768 1329 3300 2956 M10647 GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition. 14/14 Gene Ontology BP GO:0045842 6.54615375602771e-07 1.08207080423379e-06 2790 2468.63636363636 2769 5.95105063986597e-08 691 1.94195379480939 1.99304800589242 1 13.9081520728452 2788 3035 2707 2053 2769 2367 691 3606 724 3354 3061 2957 M11258 GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 34/46 Gene Ontology BP GO:1900739 4.60835524817944e-07 8.38270078904538e-07 2600 2691.09090909091 2769 4.18941473954099e-08 871 1.74930130636822 2.19249884183919 1 12.7527332136827 2599 3236 2971 3791 2506 2069 2769 2706 871 3308 2776 2958 M11661 GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 34/46 Gene Ontology BP GO:1900740 4.60835524817944e-07 8.38270078904538e-07 2600 2676.18181818182 2770 4.18941473954099e-08 872 1.74930130636822 2.19249884183919 1 12.7527332136827 2600 3237 2972 3792 2507 2070 2770 2532 872 3309 2777 2959 M11898 GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. 25/28 Gene Ontology BP GO:1903205 9.88623704675272e-07 1.47912093178587e-06 2255 2694.90909090909 2770 8.98749226307041e-08 1356 1.72317177302664 1.92879408120152 1 12.0467508067157 2254 2098 3051 3550 3072 2770 3328 1356 2606 3284 2275 2960 M13109 GO_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ADAPTATION.html A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 33/50 Gene Ontology BP GO:0043500 5.46732329228838e-07 9.44651142926767e-07 2020 2661.72727272727 2770 4.97029513727184e-08 1109 2.27245530949095 -1.42956772858774 -1 16.4548121647425 2019 2918 1796 2770 2648 1656 1109 4432 3316 3712 2903 2961 M14849 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. 269/358 Gene Ontology BP GO:2000116 7.96328295148787e-08 4.02645553947883e-07 2770 2450.72727272727 2770 7.23934839975706e-09 725 2.0624635380439 2.20004570159387 1 15.8485254988768 2770 3881 1722 2809 725 2004 3659 1567 2905 3047 1869 2962 M15715 GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. 14/14 Gene Ontology BP GO:1902101 6.54615375602771e-07 1.08207080423379e-06 2790 2475.18181818182 2770 5.95105063986597e-08 692 1.94195379480939 1.99304800589242 1 13.9081520728452 2789 3036 2708 2054 2770 2368 692 3657 725 3366 3062 2963 M13924 GO_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 43/54 Gene Ontology BP GO:0034605 3.16177504869756e-07 6.46385733813257e-07 2775 2697 2772 2.87434136645329e-08 995 1.92999908856193 1.51046002887612 1 14.3441947627358 2772 3699 2623 2064 2217 995 1104 4093 3763 2909 3428 2964 M12454 GO_SPHINGOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. 11/13 Gene Ontology BP GO:0046519 0.00027067530350107 0.000283980200042949 2090 2767.36363636364 2773 2.46098737786996e-05 1309 1.40675138215637 -1.44446769112057 -1 5.93113906041838 2087 3835 3178 3454 4415 2773 2021 2293 1736 3340 1309 2965 M10932 GO_T_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 38/50 Gene Ontology BP GO:0043029 3.65946031517734e-08 4.02645553947883e-07 4390 2338.90909090909 2774 3.32678216004407e-09 111 1.67432307848069 -1.40136743077581 -1 12.8465737339815 4390 618 2774 998 111 3293 2089 4188 331 3639 3297 2966 M10265 GO_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXPORT_FROM_NUCLEUS.html The directed movement of a protein from the nucleus into the cytoplasm. 51/55 Gene Ontology BP GO:0006611 6.56877942402893e-07 1.08423308478207e-06 1565 2607.27272727273 2775 5.97161944121974e-08 69 1.14987168536148 1.12625753675726 1 8.19210937790015 1562 4173 3967 4236 2775 543 557 2444 4415 3939 69 2967 M14579 GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 155/224 Gene Ontology BP GO:0050731 7.87679516749063e-08 4.02645553947883e-07 3865 2488.63636363636 2775 7.16072313591672e-09 341 2.34613048944594 2.32164148065669 1 18.0424593813741 3861 1761 341 952 708 3864 4522 4469 2775 401 3721 2968 M10793 GO_POSITIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BINDING.html Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 181/216 Gene Ontology BP GO:0051099 2.58616209309443e-07 5.67775356325191e-07 2780 3060.36363636364 2776 2.35105672464103e-08 2058 1.54166475618821 -1.45214489808859 -1 11.5422879714811 2776 3139 3702 4245 2058 2736 2485 2694 3921 3177 2731 2969 M11150 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. 94/110 Gene Ontology BP GO:0048010 1.00907626601298e-07 4.02645553947883e-07 3750 2839.18181818182 2776 9.17342102087627e-09 1021 1.87148046841003 -1.49729543194331 -1 14.3714262972174 3750 2834 2246 2079 1021 4104 3287 2776 2541 2293 4300 2970 M16427 GO_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATED_EXOCYTOSIS.html A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. 224/351 Gene Ontology BP GO:0045055 1.06305884862558e-07 4.02645553947883e-07 3725 2492.36363636364 2777 9.66417181812265e-09 378 2.16514771527499 -2.0455346495524 -1 16.6427043572534 3723 1632 378 2164 1090 4152 2777 4119 2922 965 3494 2971 M10068 GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0052192 6.5951851085547e-07 1.08479953043585e-06 3205 2621.18181818182 2778 5.99562462333422e-08 1851 2.20155334672995 -2.42907910741176 -1 15.7782389175341 3205 3447 2257 2842 2778 3114 2211 1942 3019 2167 1851 2972 M14920 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 16/24 Gene Ontology BP GO:0042347 8.26493588250482e-06 9.87082819848432e-06 1165 1965 2778 7.51360630208058e-07 107 2.10156569062634 -1.72485137886115 -1 12.6195330681646 1164 3331 2844 2778 3870 721 107 2817 182 3586 215 2973 M15240 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. 15/24 Gene Ontology BP GO:0061081 8.11196742215816e-07 1.2713029442675e-06 4295 2696.27272727273 2778 7.37451855750121e-08 1113 2.10238071330854 1.87323471766886 1 14.8876590161514 4295 1113 1679 2310 2924 2778 1827 3790 3221 2677 3045 2974 M10524 GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0051806 6.5951851085547e-07 1.08479953043585e-06 3210 2588.81818181818 2779 5.99562462333422e-08 1576 2.20155334672995 -2.42907910741176 -1 15.7782389175341 3206 3448 2258 2843 2779 3115 2212 1576 3020 2168 1852 2975 M11781 GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 13/28 Gene Ontology BP GO:0030656 3.4965006014595e-06 4.46711073547256e-06 650 2510.90909090909 2780 3.17864196229528e-07 132 2.42734716028207 -2.00457313463878 -1 15.6025693061212 649 4078 1696 4146 3616 896 132 4184 3809 2780 1634 2976 M12914 GO_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_ENTRY_INTO_HOST_CELL.html The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. 92/135 Gene Ontology BP GO:0046718 6.5951851085547e-07 1.08479953043585e-06 3210 2641.09090909091 2780 5.99562462333422e-08 1853 2.20155334672995 -2.42907910741176 -1 15.7782389175341 3207 3449 2259 2844 2780 3116 2213 2141 3021 2169 1853 2977 M15058 GO_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. 12/19 Gene Ontology BP GO:0046339 1.40965786281031e-06 1.98401029511686e-06 1545 2574.72727272727 2780 1.28150796914039e-07 1090 2.34617479344615 -1.85371155500213 -1 16.0775193066192 1541 3377 1952 3737 3276 1478 1090 3021 3495 2575 2780 2978 M12938 GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0051828 6.5951851085547e-07 1.08479953043585e-06 3210 2642.09090909091 2781 5.99562462333422e-08 1854 2.20155334672995 -2.42907910741176 -1 15.7782389175341 3208 3450 2260 2845 2781 3117 2214 2142 3022 2170 1854 2979 M16914 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. 19/23 Gene Ontology BP GO:2000651 8.96864579934072e-07 1.37363755445465e-06 3000 2213.72727272727 2781 8.15331768686566e-08 102 1.90116162916978 -1.77556747483665 -1 13.3755972192975 2999 954 2303 1783 2998 2832 2781 1384 102 2925 3290 2980 M11977 GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS.html The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. 13/17 Gene Ontology BP GO:0016973 1.90004333283921e-05 2.15631747017094e-05 2190 2608.63636363636 2782 1.72732703897911e-06 702 1.9304930498766 -2.07207175464067 -1 10.7915779061732 2189 4087 3250 2987 4076 2782 1745 2163 819 3895 702 2981 M15136 GO_MOVEMENT_IN_HOST_ENVIRONMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_HOST_ENVIRONMENT.html The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0052126 6.5951851085547e-07 1.08479953043585e-06 3210 2612.81818181818 2782 5.99562462333422e-08 1810 2.20155334672995 -2.42907910741176 -1 15.7782389175341 3209 3451 2261 2846 2782 3118 2215 1810 3023 2171 1855 2982 M12737 GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS.html Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. 31/57 Gene Ontology BP GO:0036473 2.69726670072977e-07 5.80767328019232e-07 2105 2867.63636363636 2783 2.45206093765718e-08 922 1.63289075619618 -0.97943828696279 -1 12.2119763875985 4264 2025 2469 2103 2101 3528 2783 3947 922 3302 4100 2983 M15286 GO_ENTRY_INTO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST.html Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0044409 6.5951851085547e-07 1.08479953043585e-06 3210 2609.63636363636 2783 5.99562462333422e-08 1765 2.20155334672995 -2.42907910741176 -1 15.7782389175341 3210 3452 2262 2847 2783 3119 2216 1765 3024 2172 1856 2984 M16658 GO_LOCOMOTORY_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_EXPLORATION_BEHAVIOR.html The specific movement from place to place of an organism in response to a novel environment. 18/24 Gene Ontology BP GO:0035641 1.57127302777118e-06 2.17917537949905e-06 2850 2733 2784 1.42843104545371e-07 1530 2.54321380225337 2.80519125547158 1 17.311074059093 2850 3305 1603 2557 3323 2554 2574 3417 3566 1530 2784 2985 M16749 GO_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST_CELL.html The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0030260 6.5951851085547e-07 1.08479953043585e-06 3215 2626.81818181818 2784 5.99562462333422e-08 1857 2.20155334672995 -2.42907910741176 -1 15.7782389175341 3211 3453 2263 2848 2784 3120 2217 1944 3025 2173 1857 2986 M10602 GO_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_UPTAKE.html The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. 13/22 Gene Ontology BP GO:0001504 1.71107588338555e-06 2.35342479615517e-06 3070 2449.81818181818 2785 1.55552474017854e-07 1126 2.56104268341807 2.68024522506656 1 17.329677298993 3069 1126 1168 1525 3351 2785 3460 3872 1723 1373 3496 2987 M13880 GO_RETINAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. 13/26 Gene Ontology BP GO:0042574 7.62868642998084e-07 1.20900129287128e-06 2770 2753.90909090909 2787 6.93517188663072e-08 1542 2.63302821613947 2.12844216015083 1 18.7408282348853 2767 3062 1542 2979 2892 2550 2294 2848 4097 2787 2475 2988 M14880 GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that stops or reduces the activity of a monooxygenase. 13/24 Gene Ontology BP GO:0032769 5.76433230176709e-07 9.86082286769201e-07 4150 2888.36363636364 2788 5.24030346555434e-08 1239 1.68519370933196 -1.19152217532508 -1 12.1378603616615 4147 3046 2709 2322 2678 3681 1724 1239 2985 2788 4453 2989 M11580 GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that activates or increases the frequency, rate, or extent of a homeostatic process. 205/279 Gene Ontology BP GO:0032846 2.02607637452049e-07 4.98800707441474e-07 3285 2896.72727272727 2790 1.84188778282797e-08 1816 1.98055559126568 1.93426842549399 1 14.992263075171 3282 2790 1828 2503 1816 3019 4494 3863 2632 2051 3586 2990 M12291 GO_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by the detection of a hormone. 142/264 Gene Ontology BP GO:0009755 2.31572479345477e-07 5.33947842613729e-07 2930 2644.36363636364 2790 2.10520457928046e-08 1727 1.78716638779927 -1.53502518591458 -1 13.4543903324841 2927 3150 3098 3207 1955 2488 2790 2145 1727 3756 1845 2991 M13485 GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. 355/457 Gene Ontology BP GO:0071902 7.53474825069708e-08 4.02645553947883e-07 3605 2246.18181818182 2791 6.84977137159419e-09 274 2.00495203976 -1.86305062320111 -1 15.4037206878312 3601 1535 1067 274 653 3320 3100 4267 2791 1281 2819 2992 M16773 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. 13/23 Gene Ontology BP GO:0014857 1.11507045364097e-06 1.62493668048589e-06 3480 2831.18181818182 2791 1.01370092619551e-07 1232 2.74884646789856 2.41133305748927 1 19.1428131651241 3479 4559 2226 1797 3162 3050 2724 1577 1232 2791 4546 2993 M11177 GO_REGULATION_OF_BODY_FLUID_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BODY_FLUID_LEVELS.html Any process that modulates the levels of body fluids. 509/777 Gene Ontology BP GO:0050878 8.38649081345381e-09 1.41899424563639e-07 4085 2557.18181818182 2792 8.38649084510374e-10 154 2.33007588838898 -2.1210605042805 -1 19.1946757630334 4081 1446 4283 344 681 3697 2792 4227 2043 154 4381 2994 M13196 GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of the same species. 41/65 Gene Ontology BP GO:0051703 6.66167617977915e-07 1.09220504808007e-06 4575 2857.72727272727 2792 6.05607108814419e-08 577 2.16324138846711 -1.84486329800933 -1 15.4941404144743 4575 577 1502 1174 2792 4250 4643 4206 2511 1631 3574 2995 M15175 GO_LIPOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving liposaccharide. 93/115 Gene Ontology BP GO:1903509 8.7371398607471e-07 1.34571041946562e-06 2450 2694.54545454545 2792 7.94285757330958e-08 1760 1.66042129355458 -1.59556270002782 -1 11.686747883694 2449 2423 3372 2689 2979 2998 2859 1822 1760 2792 3497 2996 M14120 GO_SOCIAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOCIAL_BEHAVIOR.html Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. 41/65 Gene Ontology BP GO:0035176 6.66167617977915e-07 1.09220504808007e-06 4580 2852.09090909091 2793 6.05607108814419e-08 578 2.16324138846711 -1.84486329800933 -1 15.4941404144743 4576 578 1503 1175 2793 4251 4644 4134 2512 1632 3575 2997 M13258 GO_FC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 201/363 Gene Ontology BP GO:0038093 1.99822720772216e-07 4.9446553554843e-07 2345 2742.27272727273 2794 1.81657035383471e-08 1533 1.60300691549761 -1.45684518530144 -1 12.1220460318077 2344 2794 3525 1682 1802 3045 2158 3714 1533 4249 3319 2998 M11929 GO_RESPONSE_TO_INTERFERON_ALPHA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_ALPHA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. 26/37 Gene Ontology BP GO:0035455 1.17243116319287e-06 1.693673456174e-06 2690 2655.45454545455 2795 1.06584708000834e-07 1541 1.7354789561925 -1.93028223974473 -1 12.0100571479515 2815 2961 2847 2687 3184 2625 2686 3146 1541 2795 1923 2999 M12876 GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-8 production. 66/109 Gene Ontology BP GO:0032677 1.35478280519156e-07 4.23886744058351e-07 2795 2755.36363636364 2795 1.23162080783682e-08 1385 2.03211707813358 -2.08095528514932 -1 15.5589487524525 2795 3679 2057 2788 1385 3353 2798 2280 3406 2344 3424 3000 M16880 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin depolymerization. 17/21 Gene Ontology BP GO:0030836 1.5204711347189e-07 4.38336566905022e-07 3010 2590.72727272727 2795 1.38224658163837e-08 1166 2.36534489923563 -2.45336289400336 -1 18.0855530781836 3009 3016 2170 2243 1518 2795 3829 1166 2816 2601 3335 3001 M16339 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 48/52 Gene Ontology BP GO:0070059 7.95271075726976e-08 4.02645553947883e-07 2240 2816.90909090909 2799 7.22973731340892e-09 723 1.40610125205129 -1.28144103823283 -1 10.7720953708156 2237 3695 3673 3828 723 2540 1427 2673 4287 3104 2799 3002 M12540 GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. 21/22 Gene Ontology BP GO:0031061 4.71109060240633e-06 5.88791420171814e-06 2595 2925.90909090909 2800 4.2828188098079e-07 402 1.33491183505105 1.5795636013474 1 8.34061945600738 2593 4239 3590 4343 3698 2635 2696 1746 2800 3443 402 3003 M10063 GO_CARDIAC_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_ADAPTATION.html The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. 12/17 Gene Ontology BP GO:0014887 2.14822321012807e-06 2.87232258526607e-06 2520 2851.90909090909 2803 1.95293209799629e-07 1429 1.58717813722403 -1.17341575933031 -1 10.5346243729321 2519 2715 2938 2803 3447 2407 1465 4213 1429 4086 3349 3004 M14988 GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 44/66 Gene Ontology BP GO:0071391 6.69959141513863e-07 1.09442911533166e-06 3435 2887.36363636364 2803 6.09053950485925e-08 1306 2.31562101960653 2.24399274219804 1 16.5903324262237 3434 1933 1579 2447 2803 3794 4550 3562 1306 2465 3888 3005 M16632 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 59/106 Gene Ontology BP GO:0042346 5.74585052097768e-06 7.05865669752038e-06 2010 2785.45454545455 2803 5.22351411614456e-07 1088 2.3679663600763 -2.19735917206909 -1 14.6493349231118 2007 3924 2382 4172 3761 2803 2917 1088 1403 3433 2750 3006 M13805 GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. 12/17 Gene Ontology BP GO:0003299 2.14822321012807e-06 2.87232258526607e-06 2520 2852.18181818182 2804 1.95293209799629e-07 1430 1.58717813722403 -1.17341575933031 -1 10.5346243729321 2520 2716 2939 2804 3448 2408 1466 4204 1430 4089 3350 3007 M14907 GO_PROTEIN_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPHOSPHORYLATION.html The process of removing one or more phosphoric residues from a protein. 183/224 Gene Ontology BP GO:0006470 8.05951485337124e-08 4.02645553947883e-07 4600 2971.09090909091 2804 7.32683195329525e-09 741 1.81603800574496 2.07651303765954 1 13.9426237991866 4599 2375 2786 1918 741 3465 4236 3907 1809 2804 4042 3008 M12238 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/21 Gene Ontology BP GO:0051589 6.72203611759315e-07 1.09702807206058e-06 2075 2738.81818181818 2805 6.11094379226605e-08 1763 1.92207708382444 -1.99909545968209 -1 13.7508833514122 2071 2995 2713 2083 2805 2972 2631 3053 4123 2918 1763 3009 M16881 GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. 12/17 Gene Ontology BP GO:0014898 2.14822321012807e-06 2.87232258526607e-06 2525 2854.09090909091 2805 1.95293209799629e-07 1431 1.58717813722403 -1.17341575933031 -1 10.5346243729321 2521 2717 2940 2805 3449 2409 1467 4212 1431 4093 3351 3010 M10228 GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 26/28 Gene Ontology BP GO:0022011 5.48241449569772e-07 9.46061231344861e-07 2810 3018.36363636364 2806 4.98401441992682e-08 2426 1.52446099444063 1.76823571605081 1 11.0035138314421 2806 2591 3034 2785 2650 3247 4009 2768 3771 3115 2426 3011 M12127 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an external stimulus. 281/449 Gene Ontology BP GO:0032103 5.34626972822981e-08 4.02645553947883e-07 2945 2166.72727272727 2809 4.86024532559157e-09 299 2.11799724444714 -2.11914059728517 -1 16.2780336932453 2941 1584 552 1379 299 3418 2809 3797 3145 719 3191 3012 M16655 GO_RESPONSE_TO_IRON_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IRON_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. 34/50 Gene Ontology BP GO:0010039 1.54161742920127e-07 4.40340448009425e-07 3905 2718.09090909091 2809 1.40147048838895e-08 562 2.39804225904391 -1.8590584570945 -1 18.3312371558013 3905 706 1644 2009 1535 4144 4368 4337 562 2809 3880 3013 M10348 GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 6/15 Gene Ontology BP GO:0035589 2.25423340677011e-07 5.24447402085065e-07 3510 2639.45454545455 2810 2.25423363544071e-08 1279 4.6328329806499 -3.76720577357142 -1 35.085149627958 3507 1279 4235 1314 2004 3425 2810 3098 2166 1519 3677 3014 M11866 GO_AMINO_ACID_BETAINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_TRANSPORT.html The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/40 Gene Ontology BP GO:0015838 1.31043334038828e-05 1.51942345697151e-05 1530 2516.09090909091 2810 1.19131013279042e-06 327 1.52910332197101 -1.36910448191187 -1 8.80753219490164 1528 3781 3405 2810 3986 1396 327 951 3680 3880 1933 3015 M14853 GO_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. 16/21 Gene Ontology BP GO:0030225 1.61271579274485e-06 2.23265890617132e-06 2400 2645.90909090909 2810 1.46610634086511e-07 946 1.80640891123117 1.572461484172 1 12.2429785772677 2396 3332 2810 1665 3330 2112 946 4458 1575 2866 3615 3016 M16752 GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT.html Any process that modulates the frequency, rate or extent of synaptic vesicle transport. 46/58 Gene Ontology BP GO:1902803 1.05508956397306e-06 1.55506231902649e-06 2550 2588.54545454545 2810 9.59172790890687e-08 1854 1.61219643281475 -1.21379280229219 -1 11.2218914972024 2547 1940 2994 3245 3120 1913 1854 2076 2810 2928 3047 3017 M10723 GO_MEMBRANE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DISASSEMBLY.html The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. 54/57 Gene Ontology BP GO:0030397 9.92088025468779e-07 1.48287362110704e-06 1120 2515.54545454545 2811 9.0189861168206e-08 577 1.38252052860703 1.45126914519944 1 9.64305314565767 1117 3476 3653 3055 3074 1060 577 2103 2811 4058 2687 3018 M10138 GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. 27/30 Gene Ontology BP GO:0019682 3.54032757169751e-05 3.92589508951745e-05 1240 2631.27272727273 2812 3.21853140485601e-06 781 1.89013052655218 -1.76250210897274 -1 9.96894073723753 1236 2950 2812 3193 4172 2454 2265 781 3238 3483 2360 3019 M15629 GO_NUCLEAR_ENVELOPE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_DISASSEMBLY.html The controlled breakdown of the nuclear envelope in the context of a normal process. 54/57 Gene Ontology BP GO:0051081 9.92088025468779e-07 1.48287362110704e-06 1120 2520.90909090909 2812 9.0189861168206e-08 578 1.38252052860703 1.45126914519944 1 9.64305314565767 1118 3477 3654 3056 3075 1061 578 2152 2812 4059 2688 3020 M11815 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. 123/161 Gene Ontology BP GO:0097202 1.45842267679921e-07 4.33702742561904e-07 2895 2672.63636363636 2814 1.32583888498263e-08 1031 2.40579479438332 2.55161142469037 1 18.4100249977573 2893 3158 1031 2276 1466 3690 4248 3757 2814 1997 2069 3021 M13509 GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 1102/1576 Gene Ontology BP GO:0044092 8.83149770117719e-08 4.02645553947883e-07 975 2814.45454545455 2814 8.83149805215629e-09 972 1.95789061443292 2.1493359613643 1 15.0397387185769 3809 1337 4431 2380 972 2814 4490 3626 2794 975 3331 3022 M13934 GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 175/244 Gene Ontology BP GO:0046824 1.97748928383262e-07 4.93246485651519e-07 3375 2807.81818181818 2815 1.79771769234636e-08 1129 2.04203684440208 2.04994250135696 1 15.4728653539379 3375 2799 2059 1445 1786 3172 3626 4563 1129 2815 4117 3023 M11044 GO_MALE_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DETERMINATION.html The specification of male sex of an individual organism. 8/17 Gene Ontology BP GO:0030238 0.000242341302100908 0.0002548856416536 1385 2748.36363636364 2816 2.42367734345911e-05 678 1.22871716531491 -1.38195976465785 -1 5.23723911870153 1382 3099 4275 2611 4413 1022 678 3740 4394 2816 1802 3024 M15405 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. 20/38 Gene Ontology BP GO:1901984 5.09345105645084e-06 6.32182148362037e-06 2780 2812.81818181818 2816 4.63042077170232e-07 875 1.04638023811759 0.736023048745585 1 6.47652165945401 2779 3545 3644 2816 3725 1395 875 1815 3795 4084 2468 3025 M15194 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 26/29 Gene Ontology BP GO:1902253 5.3955884253876e-06 6.66463311476732e-06 2865 2629.27272727273 2817 4.9050924166641e-07 800 1.98799217249109 2.10768353056954 1 12.3420943627287 2817 2079 2862 1846 3742 2161 2058 4032 800 3661 2864 3026 M10312 GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE.html Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. 74/108 Gene Ontology BP GO:0035019 7.15228879632153e-07 1.14953625930237e-06 1315 2732.54545454545 2818 6.50208283778232e-08 1315 1.90256818435073 1.99233566806354 1 13.5635473237949 1315 4155 2637 2818 2852 1591 1486 4442 3115 3307 2340 3027 M16283 GO_MYELOID_DENDRITIC_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_ACTIVATION.html The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 23/33 Gene Ontology BP GO:0001773 3.71535852930429e-06 4.72208774565771e-06 2675 3016 2818 3.37760436710375e-07 2571 1.55668803112232 -1.59298994666978 -1 9.92380698530214 2674 2967 2757 2571 3635 3457 2851 4111 2597 2738 2818 3028 M16559 GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. 42/64 Gene Ontology BP GO:0034308 6.54744810446942e-07 1.08207080423379e-06 2820 2956.72727272727 2818 5.95222732096785e-08 1489 2.34628400633306 -2.78028125637411 -1 16.8253764854041 2818 3495 1888 2442 2771 3903 4049 1489 3592 2814 3263 3029 M15020 GO_ASYMMETRIC_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. 38/51 Gene Ontology BP GO:0008105 6.83881776556319e-07 1.11068129365325e-06 4235 2643.18181818182 2820 6.21710899222475e-08 245 2.17946211396221 -1.34912473602592 -1 15.5918900079464 4233 684 2134 3384 2820 4361 3433 2912 245 2362 2507 3030 M13311 GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 20/23 Gene Ontology BP GO:0035729 1.65414704360544e-07 4.52287618430271e-07 2920 2798.81818181818 2821 1.50377015270753e-08 1611 2.3746636998663 -2.14571725114292 -1 18.1181326515783 2916 3300 2342 2327 1611 3485 3704 2821 2518 3673 2090 3031 M12689 GO_RESPONSE_TO_INACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. 13/23 Gene Ontology BP GO:0014854 6.8437987801556e-07 1.11071488399247e-06 2960 2307.63636363636 2822 6.22163719012501e-08 556 2.17699582955281 2.78034028751708 1 15.5740951012346 2958 1158 1868 3183 2822 3261 4146 887 939 3606 556 3032 M13909 GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. 10/31 Gene Ontology BP GO:0045624 1.15359729621653e-05 1.34731130002397e-05 1895 2880.63636363636 2822 1.04873031390135e-06 1724 2.15734424072371 -2.41455695040357 -1 12.6046810813635 1891 3084 2635 2122 3962 3214 3652 2822 3888 2693 1724 3033 M14245 GO_SMALL_MOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. 313/427 Gene Ontology BP GO:0044282 2.79284050869944e-07 5.94468750547965e-07 2065 2672.72727272727 2823 2.53894623931187e-08 1722 1.81268222180365 -1.87051304990546 -1 13.5457268921302 2062 2776 2823 3379 2128 2868 3145 1722 2937 2609 2951 3034 M15287 GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 30/42 Gene Ontology BP GO:0071392 6.85844131898067e-07 1.11270318888484e-06 2895 2593.72727272727 2823 6.23494859734764e-08 720 2.26525386694772 2.17535426668393 1 16.2075337859627 2891 720 1322 1995 2823 3774 4160 4517 822 2003 3504 3035 M15507 GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. 185/232 Gene Ontology BP GO:0030177 2.45932968415822e-07 5.54848870365842e-07 1880 2783.54545454545 2823 2.23575450825555e-08 1878 1.71029065115349 1.96994878213803 1 12.8367224081678 1878 4122 3013 2823 1998 2504 3445 2342 2982 3225 2287 3036 M16223 GO_ADAPTATION_OF_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTATION_OF_SIGNALING_PATHWAY.html The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. 18/26 Gene Ontology BP GO:0023058 6.35978862230105e-06 7.72639594244564e-06 1855 2595.90909090909 2823 5.78164273394105e-07 1122 1.51535504976899 1.71925641114921 1 9.26567490589721 1854 3299 2935 2906 3802 1122 1663 2823 3404 2767 1980 3037 M11254 GO_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. 137/165 Gene Ontology BP GO:0051340 6.14548190389201e-07 1.03230784472237e-06 2825 2807.63636363636 2824 5.5868032914292e-08 1137 1.16145484328265 1.25361141113764 1 8.30560732763291 1137 3436 4083 3349 2727 1563 1482 2824 3060 4400 2823 3038 M16422 GO_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING_BY_RNA.html Any process in which RNA molecules inactivate expression of target genes. 117/163 Gene Ontology BP GO:0031047 6.0188694974115e-07 1.01691357194828e-06 1890 3121 2824 5.47170104007673e-08 1361 0.92067590580384 0.965961659412438 1 6.56970964789353 1888 4138 4168 4612 2712 1669 1361 1976 4456 4527 2824 3039 M16846 GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY.html Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. 9/22 Gene Ontology BP GO:0051482 6.13354312901885e-07 1.03067447379288e-06 4650 2953.72727272727 2824 6.13354482193531e-08 742 3.42165430286544 -3.80245366113393 -1 24.6715812334939 4059 1250 4648 2412 2811 4509 3668 742 2824 921 4647 3040 M11415 GO_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 561/883 Gene Ontology BP GO:0001775 1.2076846623783e-07 4.11483088288319e-07 3400 2651.81818181818 2825 1.2076847280109e-08 228 2.04019077882356 -1.79785888488479 -1 15.6529984331807 3399 1423 4300 1083 1364 3498 2825 4526 2501 228 4023 3041 M13730 GO_ECTODERMAL_PLACODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_DEVELOPMENT.html The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0071696 1.08180617116604e-07 4.02645553947883e-07 4000 2665.63636363636 2825 9.83460203965185e-09 683 1.4251169414022 -1.30662343036201 -1 10.9191663107323 4228 2193 2825 1633 1118 4125 3998 938 683 3585 3996 3042 M15465 GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 27/29 Gene Ontology BP GO:0032075 0.000106872262795396 0.000114316468686662 1880 3068.27272727273 2825 9.71613225649883e-06 1399 1.3587579651703 1.42499200494836 1 6.37466635791296 1879 4485 3591 2825 4321 1670 1399 2477 4314 4182 2608 3043 M10894 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. 45/59 Gene Ontology BP GO:2000378 3.15275933978165e-07 6.45393277958822e-07 3390 2956.72727272727 2826 2.86614526508636e-08 1954 1.79323821370405 -1.92005023266168 -1 13.3219082554857 3387 1954 2761 2106 2213 4203 3806 4142 2826 2847 2279 3044 M14921 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT.html Any process that activates or increases the frequency, rate or extent of protein import. 148/215 Gene Ontology BP GO:1904591 2.41339634138733e-07 5.48853038928409e-07 4425 3083.81818181818 2826 2.19399691466959e-08 1510 1.9950929838223 1.98261052720408 1 15.0028591699904 4422 2815 2163 1870 1983 4554 4313 3247 1510 2826 4219 3045 M15688 GO_ECTODERMAL_PLACODE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_MORPHOGENESIS.html The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0071697 1.08180617116604e-07 4.02645553947883e-07 4000 2666.27272727273 2826 9.83460203965185e-09 684 1.4251169414022 -1.30662343036201 -1 10.9191663107323 4229 2194 2826 1634 1119 4126 3999 932 684 3589 3997 3046 M15785 GO_ECTODERMAL_PLACODE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_FORMATION.html The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0060788 1.08180617116604e-07 4.02645553947883e-07 4000 2661.81818181818 2827 9.83460203965185e-09 685 1.4251169414022 -1.30662343036201 -1 10.9191663107323 4230 2195 2827 1635 1120 4127 4000 873 685 3590 3998 3047 M13825 GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 35/39 Gene Ontology BP GO:0009262 2.80766427964315e-08 3.68884365916242e-07 1955 2781.45454545455 2828 2.55242210497716e-09 50 1.70730327746178 1.75384112954 1 13.180178973496 1952 3712 3349 3889 50 2828 2564 2820 3144 2605 3683 3048 M14616 GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT.html The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 26/28 Gene Ontology BP GO:0032292 5.48241449569772e-07 9.46061231344861e-07 2810 3025.45454545455 2830 4.98401441992682e-08 2427 1.52446099444063 1.76823571605081 1 11.0035138314421 2807 2592 3035 2786 2651 3248 4010 2830 3772 3122 2427 3049 M10650 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. 27/55 Gene Ontology BP GO:0032731 4.34148095342116e-05 4.7801492844933e-05 2155 3097.81818181818 2832 3.9468787550838e-06 1919 1.79084289989638 -1.86882849471564 -1 9.25468348795458 2152 3528 2368 3587 4198 2693 1919 2832 4390 2551 3858 3050 M10818 GO_RNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_STABILIZATION.html Prevention of degradation of RNA molecules. 38/44 Gene Ontology BP GO:0043489 2.23377507993824e-06 2.97304217590178e-06 3470 2727.72727272727 2832 2.03070668000923e-07 1136 1.45325389363292 1.52940067738025 1 9.61073064463033 1495 2905 3470 4338 3466 1136 1260 2780 2832 3955 2368 3051 M11253 GO_PHOTOTRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION.html The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. 31/64 Gene Ontology BP GO:0007602 1.56015158430776e-07 4.41300019561337e-07 3225 2654.45454545455 2836 1.4183197226795e-08 1555 2.08809868340553 -2.15460978604017 -1 15.9462561158751 3224 2032 2242 3397 1555 3221 2744 3184 2836 1800 2964 3052 M11882 GO_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 527/754 Gene Ontology BP GO:0010035 1.38822114665658e-07 4.25322209741392e-07 3920 2709.09090909091 2836 1.3882212333787e-08 689 2.30709942604041 2.46097284010327 1 17.6741925152464 3917 1452 4331 907 1524 3711 4362 2836 2320 689 3751 3053 M12235 GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. 19/19 Gene Ontology BP GO:0031065 3.65614387493082e-06 4.65318310997076e-06 2840 2634.90909090909 2836 3.32377268275493e-07 528 1.90408316256627 2.34741827359168 1 12.1761104631752 2836 3001 2646 1684 3629 2886 3346 2096 528 3834 2498 3054 M12447 GO_EATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EATING_BEHAVIOR.html The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. 21/46 Gene Ontology BP GO:0042755 1.1519265973718e-06 1.66923527174431e-06 4320 2680.90909090909 2837 1.04720654593133e-07 448 2.95076687628915 -2.22452653174128 -1 20.5148527233168 4319 945 1310 1737 3175 3868 2767 3486 448 2837 4598 3055 M16889 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 21/25 Gene Ontology BP GO:1900151 2.46003270914406e-07 5.54848870365842e-07 1905 2802 2837 2.23639362202195e-08 1034 0.955745245177516 -0.945101445014102 -1 7.12799901150662 1901 4013 3675 4524 2000 1259 1034 2837 4557 3952 1070 3056 M10254 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 94/124 Gene Ontology BP GO:1903845 1.33288164770564e-07 4.20399283289481e-07 3010 2615.09090909091 2838 1.21171066223544e-08 734 2.09436363581309 2.37151112073921 1 16.0477823952805 3006 4145 2442 1850 1373 3112 4497 1032 2838 3737 734 3057 M11774 GO_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSPORT.html The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. 26/32 Gene Ontology BP GO:0006862 4.47016699408783e-08 4.02645553947883e-07 4440 2872.18181818182 2839 4.06378825901536e-09 176 1.54362498136656 -1.37830913759248 -1 11.8357299179523 4439 796 2726 2839 176 4294 3451 4621 2415 1438 4399 3058 M15113 GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. 94/124 Gene Ontology BP GO:0030512 1.33288164770564e-07 4.20399283289481e-07 3010 2659 2839 1.21171066223544e-08 735 2.09436363581309 2.37151112073921 1 16.0477823952805 3007 4146 2443 1851 1374 3113 4498 1505 2839 3738 735 3059 M11877 GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 54/72 Gene Ontology BP GO:0009064 5.2934324635308e-07 9.23868764171373e-07 3705 2847.63636363636 2840 4.81221248835183e-08 426 1.95765469600441 1.74207840297072 1 14.183957002522 3705 426 2018 3662 2620 2146 2840 4084 3683 1965 4175 3060 M13663 GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. 115/139 Gene Ontology BP GO:0051351 2.24656388771636e-06 2.98664621986978e-06 850 2792.27272727273 2841 2.04233289257542e-07 846 1.1932418006758 1.28220455793368 1 7.86992361298052 846 3443 4041 3341 3469 1597 1362 2591 2771 4413 2841 3061 M15385 GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 29/49 Gene Ontology BP GO:0045923 2.22506136450664e-06 2.96229199686678e-06 2845 2744.81818181818 2841 2.02278510447095e-07 1630 1.91297213664174 -1.89593217493765 -1 12.6871711622226 2841 3249 2348 1630 3464 2933 3813 2294 3860 1876 1885 3062 M14592 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/80 Gene Ontology BP GO:0051926 5.95855254275911e-07 1.0096556803153e-06 2620 2908.36363636364 2843 5.41686741508523e-08 592 1.50886529694488 1.50314519613575 1 10.8383327796228 2616 592 2843 3258 2703 2601 3712 3993 4113 2034 3527 3063 M16507 GO_PROTEIN_AUTOPROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPROCESSING.html Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. 10/19 Gene Ontology BP GO:0016540 7.04589885228412e-07 1.13559291166186e-06 4060 2810.18181818182 2843 6.40536464441997e-08 1530 3.17144824912212 -4.82853627377875 -1 22.6984798670079 4057 2736 1530 2000 2843 3964 1588 3293 2970 2695 3236 3064 M11223 GO_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTATIC_PROCESS.html Any biological process involved in the maintenance of an internal steady state. 1241/1868 Gene Ontology BP GO:0042592 6.50347656805174e-08 4.02645553947883e-07 3440 2312.27272727273 2847 6.50347675838016e-09 200 2.09197814357542 -1.95107021986686 -1 16.0767970433203 3438 1328 4287 833 595 3383 2847 3118 2331 200 3075 3065 M13467 GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 23/35 Gene Ontology BP GO:0043949 1.44792246867874e-06 2.03049525218873e-06 2295 2839.90909090909 2848 1.31629401965894e-07 1225 2.06205665197972 2.29850610453705 1 14.0930052926708 2295 3997 2695 4137 3287 1765 1688 3906 2848 3396 1225 3066 M13437 GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. 29/44 Gene Ontology BP GO:0035116 1.72890975738461e-06 2.37234358629036e-06 3920 2843.18181818182 2849 1.57173737825553e-07 778 1.91848980368574 1.92706039806075 1 12.9478477977366 3919 778 2091 1427 3359 4649 4282 1877 2655 2849 3389 3067 M15457 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 508/655 Gene Ontology BP GO:0007169 7.00181356216046e-08 4.02645553947883e-07 3195 2414.63636363636 2849 7.00181378277472e-09 684 1.92434679789445 -1.69951402044254 -1 14.7803044937288 3192 1453 4558 731 684 3355 2849 3120 2076 1559 2984 3068 M10872 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME.html A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. 13/33 Gene Ontology BP GO:0001977 7.12792569166539e-07 1.14695715617305e-06 3145 2872 2850 6.47993454644571e-08 1299 1.54223415819983 -1.11474845706841 -1 10.9770196768193 3141 3052 2838 2941 2850 2662 1299 2496 3044 2774 4495 3069 M11498 GO_DRUG_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSMEMBRANE_TRANSPORT.html The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 28/45 Gene Ontology BP GO:0006855 3.12654203412848e-07 6.42946622061751e-07 2425 3063.45454545455 2850 2.84231134405345e-08 1787 2.26165814347423 -2.21599652517088 -1 16.8331905613547 2421 3513 1787 2850 2201 4095 3604 4221 2754 2711 3541 3070 M11634 GO_THIOESTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 77/99 Gene Ontology BP GO:0035383 1.5976315533915e-05 1.83459516730767e-05 555 2565.63636363636 2850 1.45240286858951e-06 552 1.47456084335354 -1.46178384908697 -1 8.34371280774683 552 2850 3342 4477 4025 1273 1077 1547 3063 3647 2369 3071 M11910 GO_FOREBRAIN_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_REGIONALIZATION.html The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. 12/33 Gene Ontology BP GO:0021871 1.10901750078988e-07 4.02645553947883e-07 4300 2755.09090909091 2851 1.00819777881394e-08 460 1.92855237593242 1.73929395586444 1 14.8128312301264 4296 2718 2851 2292 1157 3624 3411 4001 460 3079 2417 3072 M15311 GO_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 77/99 Gene Ontology BP GO:0006637 1.5976315533915e-05 1.83459516730767e-05 555 2555.72727272727 2851 1.45240286858951e-06 553 1.47456084335354 -1.46178384908697 -1 8.34371280774683 553 2851 3343 4478 4026 1274 1078 1428 3064 3648 2370 3073 M11408 GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. 14/19 Gene Ontology BP GO:0035886 8.71583830447459e-07 1.34331883506857e-06 3765 2491.45454545455 2852 7.92349250679011e-08 1191 2.33912020694458 -2.18456299497806 -1 16.5079875967934 3761 2689 1568 1206 2978 4038 2852 1191 2926 1204 2993 3074 M13372 GO_PHOSPHATE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSPORT.html The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/20 Gene Ontology BP GO:0006817 4.7349878347335e-06 5.91427369118992e-06 3945 2884.90909090909 2852 4.30454365974837e-07 334 2.34562986920263 1.79591700618838 1 14.728104568037 3941 1205 2175 2852 3700 3817 4501 2323 334 2571 4315 3075 M13764 GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. 13/27 Gene Ontology BP GO:0060219 1.92308955469786e-05 2.18140801999247e-05 4405 2584.18181818182 2852 1.74827851385216e-06 1042 2.67656586900788 -2.03982490484246 -1 14.9856983561522 4404 1143 1105 1949 4078 4139 3198 3134 1042 1382 2852 3076 M14071 GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 72/90 Gene Ontology BP GO:0071479 1.17979037631564e-06 1.70260102401526e-06 3555 2746.18181818182 2852 1.07253728090941e-07 949 1.73683968355423 1.87402174483829 1 12.0147585848313 3555 2852 2721 2123 3187 3277 2797 949 3367 3046 2334 3077 M16392 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 6/14 Gene Ontology BP GO:0045086 0.000204381649029724 0.000215692404839035 2750 2952.72727272727 2852 2.04400448799551e-05 576 1.87582504813014 -0.984501992208418 -1 8.21416981206132 2852 2747 4621 2586 4400 3276 1994 2750 576 2940 3738 3078 M11119 GO_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING.html The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. 458/612 Gene Ontology BP GO:0006605 1.59374813569547e-07 4.451187824325e-07 1620 3113 2853 1.44886204650139e-08 1452 1.2098476833816 -1.07064066417705 -1 9.19050694926802 1618 4621 4190 4636 1580 2019 1452 2853 3962 4589 2723 3079 M11445 GO_HIPPO_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPO_SIGNALING.html The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. 37/37 Gene Ontology BP GO:0035329 3.74495538181735e-08 4.02645553947883e-07 3150 2496.81818181818 2853 3.4045049505145e-09 120 2.19538874808344 2.41595337423639 1 16.8765942277238 3149 3499 2290 938 120 4284 3613 4141 407 2853 2171 3080 M14243 GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. 9/13 Gene Ontology BP GO:0052803 8.90062239419164e-08 4.02645553947883e-07 2905 2712.18181818182 2853 8.90062275068652e-09 981 2.82327439325742 3.36970734123831 1 21.7327806268525 2904 2284 4482 2853 981 2728 3080 4409 1603 1331 3179 3081 M16144 GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 138/173 Gene Ontology BP GO:0010811 2.05030949574528e-07 5.00119458251237e-07 2855 2329.45454545455 2853 1.86391789711429e-08 315 2.24860267062708 2.63982516906498 1 17.0321218762916 2853 1783 315 940 1828 3082 4652 3422 3078 380 3291 3082 M11925 GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 16/23 Gene Ontology BP GO:0071732 7.7057065963321e-06 9.2289968578464e-06 2130 2401.81818181818 2855 7.00521235129583e-07 435 1.73974298465282 2.05099288347767 1 10.490561256658 2127 3017 2855 3451 3860 1657 786 459 4192 3581 435 3083 M11057 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 11/14 Gene Ontology BP GO:0033147 7.16378173219562e-07 1.14981291479497e-06 2850 3020.90909090909 2857 6.51253096810314e-08 2022 1.20848670106644 1.62209246144638 1 8.57767673688834 2846 2273 3015 3933 2857 2734 2035 3970 4208 3337 2022 3084 M13024 GO_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 89/116 Gene Ontology BP GO:0048145 1.47661458239777e-07 4.36788789058922e-07 3595 2646.72727272727 2858 1.34237698318768e-08 1113 1.86432580080666 1.92526834161246 1 14.2363899349147 3594 1847 2100 3002 1476 2858 3521 3111 1113 2705 3787 3085 M13521 GO_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_REMODELING.html Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. 45/59 Gene Ontology BP GO:0046850 7.1710877297086e-07 1.15058866228738e-06 4525 2457.36363636364 2858 6.51917278835172e-08 134 3.40776609147171 2.79227896990392 1 24.3740291176002 4524 2879 388 134 2858 4060 3419 1761 2787 676 3545 3086 M14575 GO_PEROXISOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOMAL_TRANSPORT.html Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 21/21 Gene Ontology BP GO:0043574 5.58869472384635e-05 6.09282955718301e-05 1755 2576.54545454545 2859 5.08076063580892e-06 534 1.37287632855426 -0.854575123104094 -1 6.89573049818749 1752 3774 3479 3547 4464 1285 959 534 2859 4258 1431 3087 M15445 GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. 10/20 Gene Ontology BP GO:0036148 5.70978754366962e-05 6.221930079788e-05 1005 2489.63636363636 2859 5.19085067134604e-06 187 1.91510013291667 -2.18621198461764 -1 9.63880376297727 1005 4319 2859 4332 4241 755 187 930 4400 3193 1165 3088 M14797 GO_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_REACTION.html The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg. 12/28 Gene Ontology BP GO:0007340 6.05109407653333e-06 7.39383947954558e-06 4250 2932.09090909091 2860 5.50100974555944e-07 1567 2.15044725814205 -1.40521450303021 -1 13.2418038631831 4248 2724 2117 3149 3778 3877 3481 2860 1567 1604 2848 3089 M10464 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. 56/88 Gene Ontology BP GO:0043551 2.52673045208889e-07 5.63157068499e-07 3925 2637 2861 2.29702794753403e-08 1036 2.00798044296831 -2.02111372644392 -1 15.073302213907 3923 2861 1621 1036 2026 3873 3087 3746 1700 1453 3681 3090 M12953 GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION.html Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 16/19 Gene Ontology BP GO:0051127 4.69597677418573e-07 8.47242339289888e-07 3700 2571.90909090909 2861 4.26907070596242e-08 1061 1.72191738493326 -1.82517255340062 -1 12.5418588458015 3700 1061 2861 2058 2529 3203 1542 3377 1807 3235 2918 3091 M13042 GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. 18/21 Gene Ontology BP GO:0009200 8.86007983462237e-09 1.49369389385862e-07 2550 2562.54545454545 2861 8.05461806391332e-10 1 1.53918010274833 1.71652982878077 1 12.6030199266399 2550 2184 2950 3417 1 3321 3127 2389 2861 1527 3861 3092 M10337 GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-5 production. 16/42 Gene Ontology BP GO:0032674 2.58933871936827e-07 5.67775356325191e-07 2975 2950.63636363636 2862 2.35394456738752e-08 2062 2.3983540832856 -3.06991796974856 -1 18.0134469722921 2973 2680 2224 2120 2062 3834 4622 3264 2786 2862 3030 3093 M11577 GO_VENTRICULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. 40/67 Gene Ontology BP GO:0021591 9.98590157343298e-07 1.48938583833461e-06 2215 2749 2862 9.07809646007518e-08 1024 1.90539069212395 1.90586506321455 1 13.3246154166099 2214 3945 2612 3432 3079 2862 3907 1024 2007 3139 2018 3094 M15630 GO_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 1700/2497 Gene Ontology BP GO:0051049 1.65900409406027e-14 7.35175814253567e-13 3260 2245.18181818182 2862 1.65900409406029e-15 63 2.1258436575649 -1.96263512620929 -1 31.0924250447991 3259 1298 4566 300 719 3254 2862 3436 1768 63 3172 3095 M13147 GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING.html Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. 9/19 Gene Ontology BP GO:0010738 6.59552519149585e-07 1.08479953043585e-06 385 2048.45454545455 2864 6.59552714903953e-08 6 1.86516801085952 1.86516801085952 1 13.3516787346768 384 3857 4410 3764 2864 196 6 121 3848 3026 57 3096 M12871 GO_PROTEIN_LOCALIZATION_TO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMATIN.html Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. 16/19 Gene Ontology BP GO:0071168 1.09068774285874e-05 1.27832999181908e-05 2360 2802.72727272727 2865 9.91539227425341e-07 1041 1.86646343951914 1.90834082194032 1 10.9427970543224 2356 3569 2474 3723 3948 1343 1041 3047 4046 2865 2418 3097 M12870 GO_POSITIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION.html Any process that activates or increases the frequency, rate or extent of cell adhesion. 385/579 Gene Ontology BP GO:0045785 1.30497691446281e-10 3.22981786329544e-09 3665 2350.81818181818 2868 1.18634264958201e-11 107 2.08646950542201 -1.84281447326595 -1 21.3225333532618 3665 1506 150 1277 763 3592 2868 4250 3380 107 4301 3098 M10306 GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING.html Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. 36/62 Gene Ontology BP GO:0010955 1.38218514840963e-07 4.24835370983751e-07 2970 2625.54545454545 2869 1.2565320320433e-08 1253 2.55458614104432 -2.5419263345947 -1 19.5827161826093 2967 1990 1253 2869 1410 3508 2957 4561 3575 1833 1958 3099 M11490 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE.html The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 406/551 Gene Ontology BP GO:0072594 1.6356968351204e-07 4.50082635944129e-07 1800 3195.63636363636 2869 1.48699723339476e-08 1603 1.09469333504446 -1.07719398815035 -1 8.29957049858121 1796 4625 4194 4645 1603 2435 1792 2360 4224 4609 2869 3100 M13745 GO_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_POLARITY.html The maintenance of established anisotropic intracellular organization or cell growth patterns. 12/17 Gene Ontology BP GO:0030011 1.38804567420199e-07 4.25322209741392e-07 3900 2742.54545454545 2869 1.2618597834345e-08 650 1.50291690405893 1.63132116523655 1 11.4776353091625 3897 3056 2869 2522 1416 4173 4604 650 824 2573 3584 3101 M16081 GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. 57/60 Gene Ontology BP GO:1904356 8.58623489401869e-06 1.02335427668722e-05 1265 2631.27272727273 2870 7.80569854986512e-07 549 1.32374254910213 1.24953818834663 1 7.88564485723975 1265 4420 3829 3117 3877 1298 734 2870 549 4470 2515 3102 M16083 GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI.html The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. 19/21 Gene Ontology BP GO:0000301 7.33919020715052e-07 1.17230525347996e-06 1340 2621.36363636364 2870 6.67199332318386e-08 919 1.09465319152066 -1.15431037009005 -1 7.74886519043353 1338 3788 3749 4511 2870 1148 919 1202 4261 4046 1003 3103 M16220 GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. 36/62 Gene Ontology BP GO:1903318 1.38218514840963e-07 4.24835370983751e-07 2970 2625.45454545455 2870 1.2565320320433e-08 1254 2.55458614104432 -2.5419263345947 -1 19.5827161826093 2968 1991 1254 2870 1411 3509 2958 4546 3576 1838 1959 3104 M16607 GO_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION.html The addition of tubulin heterodimers to one or both ends of a microtubule. 28/34 Gene Ontology BP GO:0046785 1.01609946340943e-05 1.19724254323729e-05 2870 2531 2870 9.23731051301113e-07 359 1.24776988948355 1.71032334388142 1 7.32430941240333 2870 3511 3501 3035 3923 1645 968 1471 2596 3962 359 3105 M13604 GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. 14/20 Gene Ontology BP GO:0060766 1.32741388070358e-07 4.20399283289481e-07 3260 2549.90909090909 2871 1.20673996435977e-08 1027 1.65522570478792 1.17298216626266 1 12.6613587044335 3258 1114 2871 1027 1362 3145 3648 3558 2065 2492 3509 3106 M10600 GO_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. 32/41 Gene Ontology BP GO:0031063 4.75778900940898e-07 8.54684230164491e-07 3545 2648.45454545455 2872 4.32526367122152e-08 478 1.76644589758297 2.047907614077 1 12.8607379286716 3542 746 2872 1226 2541 3654 4390 2578 478 3823 3283 3107 M13624 GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 20/24 Gene Ontology BP GO:0051043 3.3979627992467e-05 3.77975637219577e-05 3035 2972.63636363636 2872 3.08910480262451e-06 572 2.2193800850253 -1.8526815123741 -1 11.7676263263947 3034 3287 2458 2872 4161 2735 2586 3862 572 2649 4483 3108 M16136 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT.html The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 44/55 Gene Ontology BP GO:1901264 2.7854129918297e-07 5.9397464028339e-07 2875 2836.54545454545 2872 2.53219394953637e-08 1154 1.76034954896829 -1.87909032016048 -1 13.1524541462657 2872 1948 2919 4107 2124 3291 4192 1154 2105 2729 3761 3109 M14388 GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. 18/28 Gene Ontology BP GO:0014874 8.66814818533208e-07 1.3364113156511e-06 3520 2604.27272727273 2875 7.88013781876612e-08 788 2.56141576510172 -1.97739371906991 -1 18.0935251823329 3519 3005 1860 2728 2977 2618 834 2875 788 3455 3988 3110 M12509 GO_PROTEIN_TRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRIMERIZATION.html The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. 48/65 Gene Ontology BP GO:0070206 9.03636912827834e-06 1.07233424008873e-05 2720 2786.63636363636 2876 8.21491476803674e-07 958 2.3697480327427 2.30200126809035 1 14.1399517858921 2718 2876 958 1404 3894 3897 4020 3726 2402 999 3759 3111 M13189 GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of stem cell differentiation. 71/92 Gene Ontology BP GO:2000738 7.39770624251753e-07 1.17760954999774e-06 3250 2441.18181818182 2879 6.72518975460616e-08 266 1.99742984054415 2.24049486901287 1 14.2196433246471 3249 266 1129 995 2879 4117 3208 4482 2718 800 3010 3112 M11935 GO_REGULATION_OF_GLOMERULAR_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULAR_FILTRATION.html Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. 8/13 Gene Ontology BP GO:0003093 1.96554973661952e-07 4.93246485651519e-07 2880 2789.09090909091 2880 1.9655499104719e-08 1625 1.8896348003555 2.39720556046266 1 14.3104047975741 2880 3098 4333 1625 1885 4033 3765 1828 1661 3327 2245 3113 M13074 GO_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_B_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. 46/57 Gene Ontology BP GO:0043491 2.61088087073756e-07 5.70140887477118e-07 3725 2738.54545454545 2881 2.37352834598869e-08 1312 1.78758875065967 -1.47698759632686 -1 13.3960160524441 3725 2881 2888 1460 2069 2533 1534 4606 1312 2927 4189 3114 M13267 GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. 14/21 Gene Ontology BP GO:0033605 3.45480738433942e-07 6.88152570142299e-07 4260 2794.81818181818 2883 3.14073447897371e-08 412 2.41367870549613 2.36636416719851 1 17.8854358027813 4257 3039 1889 2883 2277 3943 3388 412 2360 2041 4254 3115 M14620 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 77/87 Gene Ontology BP GO:0071230 3.37610446053042e-06 4.32755208122535e-06 2885 2780.81818181818 2883 3.06919058317055e-07 791 2.43926329769764 2.552177874935 1 15.7203341723909 2883 2442 791 1645 3606 3684 4361 4379 1633 1268 3897 3116 M14887 GO_INTERACTION_WITH_SYMBIONT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_SYMBIONT.html An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 52/80 Gene Ontology BP GO:0051702 3.63728223146778e-07 7.09613174969374e-07 2265 2833.72727272727 2883 3.30662075711224e-08 2223 1.7583579140286 -2.09312924007064 -1 12.9731728980781 2261 3688 3359 3060 2330 2538 2223 2883 3040 3402 2387 3117 M11477 GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 17/20 Gene Ontology BP GO:0010763 7.44337331194232e-07 1.18392819136605e-06 2885 2756 2884 6.76670530027123e-08 720 2.01348030258664 1.65596057618902 1 14.3290741356003 1620 3798 2884 2598 2881 1011 720 4406 3487 3696 3215 3118 M13389 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 24/54 Gene Ontology BP GO:0030813 1.52844564179052e-06 2.1280244079148e-06 4495 2707.72727272727 2884 1.38949700334194e-07 268 1.70695908895361 1.54475445075728 1 11.6063207026871 4495 905 2645 268 3310 3721 3640 2670 2215 2884 3032 3119 M14432 GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is increased. 29/50 Gene Ontology BP GO:0045777 5.51503401348133e-07 9.5077633437305e-07 4495 2788.18181818182 2884 5.01366854182645e-08 1278 2.62510963535379 2.77807896290149 1 19.0154427198864 4494 3515 1547 3445 2656 3671 1619 1934 3627 1278 2884 3120 M15527 GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of JUN kinase activity. 87/121 Gene Ontology BP GO:0043507 4.40882932212636e-07 8.14705434307147e-07 2480 2899 2884 4.00802745969262e-08 1920 1.63490817950005 -1.61487034165161 -1 11.9365381998435 2478 3669 3058 3346 2470 2202 1920 2884 4044 3247 2571 3121 M10715 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. 88/147 Gene Ontology BP GO:0070664 3.73016767009819e-07 7.21382800040185e-07 2275 2544.90909090909 2885 3.39106209323612e-08 151 1.80063874496189 -1.85489542328306 -1 13.2720391045138 2274 151 1639 2951 2355 3192 3823 3569 3670 1485 2885 3122 M16049 GO_STRIATED_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_ADAPTATION.html Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 27/42 Gene Ontology BP GO:0014888 8.38108088448709e-07 1.30120685203598e-06 2885 2794.54545454545 2885 7.61916734302768e-08 1527 2.48144878600788 -1.43471326752504 -1 17.56022764433 2885 2949 1792 3215 2953 2477 1835 2711 1527 3910 4486 3123 M14912 GO_TETRAHYDROFOLATE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_INTERCONVERSION.html The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. 12/13 Gene Ontology BP GO:0035999 3.51518923039067e-06 4.48483013134296e-06 1080 2693.81818181818 2886 3.19563167910844e-07 1080 1.270943258468 1.33991478450495 1 8.11771185265446 1080 2266 3237 3452 3621 2537 2898 1837 2886 3084 2734 3124 M16961 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. 20/23 Gene Ontology BP GO:0032703 7.57676215665305e-07 1.20323120528692e-06 4065 2920.90909090909 2886 6.88796796916196e-08 1159 1.76122807487493 1.80965509086771 1 12.5060439882326 4062 2137 2189 2718 2886 4011 4564 1159 3139 2283 2982 3125 M10687 GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. 40/54 Gene Ontology BP GO:0045599 2.94913030149669e-08 3.74023910244642e-07 3985 2659.36363636364 2887 2.68102758275471e-09 61 2.54927751775076 -2.0814753747665 -1 19.7123683849039 3984 2887 1263 1340 61 4450 4329 4439 1181 1478 3841 3126 M13724 GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of heart contraction. 39/57 Gene Ontology BP GO:0045823 1.52704269015972e-07 4.38871503231203e-07 4310 2903.54545454545 2887 1.38822072377576e-08 902 2.77635056584061 -3.07661400956303 -1 21.2442358743035 4306 2524 902 2887 1523 4552 3859 3424 2857 987 4118 3127 M12226 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 61/71 Gene Ontology BP GO:1902041 2.37814023891689e-07 5.43346316145932e-07 2890 2794.18181818182 2888 2.16194590544311e-08 1667 2.00090223893359 -1.86765748995033 -1 15.0574413770549 2888 3468 2410 3507 1973 3668 3228 1667 3793 1941 2193 3128 M14410 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 24/50 Gene Ontology BP GO:0045078 1.80095395107994e-06 2.46103927588105e-06 3980 2757.54545454545 2888 1.63723220488212e-07 710 2.63548716369659 2.56241386396943 1 17.7745170738359 3979 3532 1857 2303 3374 4547 3525 939 710 2888 2679 3129 M11647 GO_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CONTRACTION.html A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. 30/55 Gene Ontology BP GO:0003009 7.60432092754048e-07 1.20637249491462e-06 2795 2714.18181818182 2889 6.91302141452955e-08 916 1.91619065453486 -1.69366093039297 -1 13.6128295248889 2791 2936 2649 2088 2889 2894 1936 3565 916 3487 3705 3130 M14734 GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 17/18 Gene Ontology BP GO:0009219 6.86234977824307e-06 8.28503204934225e-06 2315 2892.27272727273 2889 6.23851925792764e-07 1886 1.8307155962657 1.43573019229256 1 11.1482568515046 2315 3338 3200 2562 3826 2309 1886 2634 2889 3012 3844 3131 M15328 GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 10/18 Gene Ontology BP GO:0060457 8.66227113399594e-07 1.33594788155396e-06 4440 2570.09090909091 2889 7.87479504061541e-08 119 2.91469712156254 -1.21517458229862 -1 20.6037924778056 4436 1201 1523 764 2976 4590 2889 3259 119 2156 4358 3132 M13878 GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 549/752 Gene Ontology BP GO:1901699 5.77465762679461e-08 4.02645553947883e-07 4055 2620.54545454545 2890 5.77465777685464e-09 454 1.97970924175478 2.13768793290564 1 15.2084881111812 4055 1438 4457 575 454 3812 2890 3801 1993 1172 4179 3133 M16059 GO_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 715/1000 Gene Ontology BP GO:0030162 8.37314394345312e-08 4.02645553947883e-07 2330 2770.72727272727 2890 8.37314425894605e-09 909 1.98397601706046 2.09273039033307 1 15.2414881588282 3270 2327 4591 1577 909 2329 3462 2890 2679 2977 3467 3134 M14788 GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 22/27 Gene Ontology BP GO:0090322 1.80302921972123e-06 2.46170626741869e-06 2965 2806.63636363636 2891 1.63911881582843e-07 869 2.12915147184935 2.16645850109878 1 14.3395535512096 2965 2107 1799 2757 3377 2970 4516 4039 869 2583 2891 3135 M13783 GO_VIRAL_LIFE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LIFE_CYCLE.html A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. 322/480 Gene Ontology BP GO:0019058 7.60286691997929e-08 4.02645553947883e-07 1775 3001 2892 6.91169743883897e-09 660 1.29690694806857 -1.26372847608618 -1 9.92756596018344 1771 4632 4178 4295 660 2247 1301 2489 4000 4546 2892 3136 M14184 GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR.html Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. 78/91 Gene Ontology BP GO:0000731 3.95121363696145e-06 4.99049865710685e-06 675 2439.90909090909 2892 3.59201884853043e-07 471 1.40777107010624 1.53178033124444 1 8.92374156798821 675 3460 3687 3501 3657 471 507 2191 3806 2892 1992 3137 M10410 GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. 110/127 Gene Ontology BP GO:2000058 7.64395691077776e-07 1.21059671565177e-06 2545 3113.63636363636 2894 6.94905415153786e-08 1849 1.22864956466594 1.37081462296104 1 8.6892642453642 2544 3445 4033 2630 2894 2522 2728 3263 1849 4468 3874 3138 M11249 GO_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 47/78 Gene Ontology BP GO:0006801 6.96145043360512e-07 1.12705737187072e-06 2895 2845.90909090909 2894 6.32859330583167e-08 1065 2.17716299121539 -2.13541876476451 -1 15.558596264026 2894 4176 1712 4132 2829 3917 2929 1065 3530 1739 2382 3139 M12271 GO_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOSIS_I.html The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. 70/204 Gene Ontology BP GO:0007127 5.21236480578027e-06 6.45373428453847e-06 60 2033.63636363636 2894 4.73852468659238e-07 53 1.54149887281461 1.60552572697561 1 9.57303167958762 59 3676 3444 2986 3734 53 56 728 4040 2894 700 3140 M10711 GO_NITROGEN_CYCLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_CYCLE_METABOLIC_PROCESS.html A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. 11/30 Gene Ontology BP GO:0071941 3.66648759990118e-06 4.66379628276112e-06 2640 3150.81818181818 2896 3.33317610039061e-07 2260 1.5173083162803 -1.98263732744197 -1 9.68005779886169 2638 2729 2782 3431 3631 4174 3891 2260 3524 2896 2703 3141 M12562 GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 10/20 Gene Ontology BP GO:0045076 7.67557755129185e-07 1.21392848553279e-06 3540 2815.81818181818 2897 6.97780020838597e-08 1221 2.38033335071392 -1.74686347133846 -1 16.9272826867691 3536 1221 1687 2284 2897 4100 3544 3446 2213 1615 4431 3142 M12260 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. 176/247 Gene Ontology BP GO:1900182 2.0170305688458e-07 4.97363181602517e-07 4585 3075.72727272727 2898 1.83366432161241e-08 1454 1.95198795515335 1.90630572139425 1 14.7774878342927 4584 2800 2527 1454 1811 4333 4459 2898 1557 3198 4212 3143 M15459 GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. 12/18 Gene Ontology BP GO:0014741 9.35394069290916e-08 4.02645553947883e-07 4165 2517.09090909091 2898 8.50358280965385e-09 179 1.65568481758961 -0.946916389425801 -1 12.7024218971967 4162 2262 2898 1842 922 3830 3997 1419 179 3085 3092 3144 M12133 GO_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of vacuolar transport. 37/40 Gene Ontology BP GO:1903335 2.2674376645412e-07 5.26203862998015e-07 4205 2941.45454545455 2900 2.06130718021407e-08 1130 1.70335452170735 -0.933395280273144 -1 12.831668524585 4205 2900 3188 2125 1939 3756 2338 4587 1130 3767 2421 3145 M14785 GO_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-8 secretion. 11/21 Gene Ontology BP GO:2000482 7.84814334011674e-07 1.23910548252221e-06 3805 2859.90909090909 2900 7.13467830892368e-08 1187 1.84615075211558 -2.06315161081526 -1 13.0855354470082 3803 1187 2106 1574 2900 4008 3374 3818 1959 2385 4345 3146 M10585 GO_FOREBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 9/20 Gene Ontology BP GO:0048853 5.22912770496196e-05 5.71019272733818e-05 2905 2908.09090909091 2901 5.22925075603166e-06 1277 2.76397710466187 3.2205551975933 1 14.0814832698724 2901 3606 4249 3257 4242 2036 2871 2122 1277 2447 2981 3147 M12523 GO_L_ASCORBIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 11/12 Gene Ontology BP GO:0019852 0.000698215668673814 0.000722758065926419 3715 2679.45454545455 2901 6.34943054925719e-05 137 1.93946325913985 -1.00974006900121 -1 7.26453089687531 3712 3373 2427 2221 4472 3590 1267 2199 137 2901 3175 3148 M12930 GO_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 33/81 Gene Ontology BP GO:0002377 6.45093376265919e-06 7.82690868256929e-06 1435 2691.27272727273 2901 5.86450243494524e-07 676 1.78210565335478 1.69788351744017 1 10.9027535168155 1432 3723 2901 3502 3809 1345 676 2367 3518 3867 2464 3149 M15712 GO_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that modulates the frequency, rate, or extent of receptor recycling. 23/26 Gene Ontology BP GO:0001919 8.95128482399711e-06 1.06305074747469e-05 2615 2775.45454545455 2901 8.13756476807854e-07 346 1.30622398048228 -0.795584303478828 -1 7.75381273850857 2613 3273 3283 3788 3891 1676 346 2237 2901 3863 2659 3150 M11265 GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. 76/105 Gene Ontology BP GO:1901606 3.53297157756481e-06 4.50628200394986e-06 2740 2787.36363636364 2902 3.21179750105736e-07 256 1.82817831706484 -2.17846833971947 -1 11.7174177015912 2736 256 2464 2902 3622 3567 3938 2483 3674 1943 3076 3151 M12958 GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA.html Any process of the innate immune response that takes place in the mucosal tissues. 11/97 Gene Ontology BP GO:0002227 5.21217754020439e-05 5.69435597430642e-05 2335 2928.81818181818 2902 4.73845548157351e-06 1353 3.93844858151063 -5.09683284265365 -1 20.1144929931101 2334 3847 1826 2521 4231 3240 3325 2526 4112 2902 1353 3152 M13207 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS.html Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 36/38 Gene Ontology BP GO:0036003 2.66726937283675e-06 3.48618100893522e-06 3460 2857.63636363636 2902 2.42479327875158e-07 1453 2.03282098757794 2.11249815413803 1 13.3146110322756 3456 3229 2211 1453 3530 3880 2902 2804 2378 3003 2588 3153 M14263 GO_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APPETITE.html Any process which modulates appetite, the desire or physical craving for food. 11/23 Gene Ontology BP GO:0032098 3.82547440264399e-05 4.22901696258077e-05 4585 2977.63636363636 2903 3.47776447600144e-06 930 2.92930289209418 2.07374969269657 1 15.3919249945419 4582 2735 1590 2449 4176 4401 4468 1310 930 2903 3210 3154 M15088 GO_REVERSE_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REVERSE_CHOLESTEROL_TRANSPORT.html The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. 14/24 Gene Ontology BP GO:0043691 1.14873726245533e-06 1.66565113188054e-06 4490 2377.63636363636 2904 1.04430714752066e-07 108 3.38953001775757 -2.74144153662231 -1 23.5844368207025 4488 1102 1097 108 3173 4452 3729 3762 127 1212 2904 3155 M16279 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that activates or increases the activity of the enzyme nitric-oxide synthase. 22/27 Gene Ontology BP GO:0051000 1.25480986213077e-06 1.79539676767973e-06 4490 2857.45454545455 2904 1.14073688894081e-07 932 1.58362291558167 1.25251810934404 1 10.9016427390215 4487 932 2764 1661 3212 4573 2920 1677 2904 2218 4084 3156 M11245 GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 40/69 Gene Ontology BP GO:0051349 7.31886421515871e-08 4.02645553947883e-07 3575 2635.63636363636 2905 6.65351314421775e-09 619 2.04726381409024 2.16071405180683 1 15.7309679574651 3573 1978 2033 2943 619 2627 3348 2905 3822 1479 3665 3157 M12545 GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. 46/62 Gene Ontology BP GO:1903523 1.03835945439134e-07 4.02645553947883e-07 2910 2643.09090909091 2906 9.43963184909087e-09 1019 2.07948186370449 1.69196704121788 1 15.9801484500369 3676 1939 1658 2910 1059 4466 4178 1566 3697 1019 2906 3158 M16654 GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 14/15 Gene Ontology BP GO:0060628 7.9007629355737e-07 1.24449051926961e-06 1605 2728.27272727273 2907 7.18251433903751e-08 264 1.20532294649399 -0.579219641666 -1 8.50485779830601 1605 4060 3523 4193 2907 1150 264 4011 1321 4330 2647 3159 M13184 GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 13/16 Gene Ontology BP GO:0010870 0.000174214426152192 0.000184483323824795 3095 2904.09090909091 2908 1.58389294035668e-05 1092 2.25015143546285 1.93066522412171 1 10.0585945406504 3093 3826 2663 3312 4374 2840 1092 3042 2011 2784 2908 3160 M16897 GO_FATTY_ACID_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_ELONGATION.html The elongation of a fatty acid chain by the sequential addition of two-carbon units. 11/13 Gene Ontology BP GO:0030497 5.83340161552604e-07 9.93878349214305e-07 4450 3160.45454545455 2908 5.3030937838909e-08 435 2.20705392608535 -1.62191823712806 -1 15.9193912686146 4447 2261 2097 1985 2689 4524 4332 4550 435 2908 4537 3161 M13250 GO_POST_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_MORPHOGENESIS.html The process, occurring after embryonic development, by which anatomical structures are generated and organized. 13/17 Gene Ontology BP GO:0009886 4.65676518571785e-07 8.43787292096501e-07 2910 2840.09090909091 2909 4.23342379220087e-08 1025 2.14511580006702 1.98301391827928 1 15.6541998657488 2909 3584 2298 3693 2516 3568 3870 2194 1025 3608 1976 3162 M14082 GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 22/44 Gene Ontology BP GO:0044058 3.57702487711083e-06 4.55747446692133e-06 4300 3124.36363636364 2909 3.2518460846198e-07 1510 2.83098598274772 -1.89428541139842 -1 18.18443228482 4300 2124 1510 4301 3625 3985 2909 2862 1913 2581 4258 3163 M14189 GO_DRUG_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORT.html The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/52 Gene Ontology BP GO:0015893 1.20436906161142e-07 4.11313958327346e-07 2365 2865.81818181818 2909 1.09488102503951e-08 1245 2.06627382672674 -2.05496375538789 -1 15.854878391933 2364 2909 1923 3371 1245 3781 3063 4083 2849 2658 3278 3164 M10782 GO_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDLIMB_MORPHOGENESIS.html The process in which the anatomical structures of the hindlimb are generated and organized. 35/54 Gene Ontology BP GO:0035137 2.80108014047998e-06 3.64163897559467e-06 4135 2925.27272727273 2910 2.54643973352061e-07 692 2.05810089006269 2.16209414526004 1 13.434310063702 4131 692 1995 1844 3551 4500 4469 2507 2578 2910 3001 3165 M13000 GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. 185/204 Gene Ontology BP GO:0007265 8.4127984632303e-08 4.02645553947883e-07 4535 2933.54545454545 2910 7.64799889539605e-09 792 1.69827876910714 2.03058131922839 1 13.0318515785955 4531 2373 2910 2750 792 3925 2961 3470 2210 2348 3999 3166 M15027 GO_SCHWANN_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DEVELOPMENT.html The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 32/34 Gene Ontology BP GO:0014044 3.69742030522684e-07 7.16336250094093e-07 2395 2694 2910 3.3612917514839e-08 1478 1.52637651310476 1.85238687859271 1 11.2404699136021 2393 2020 2968 1646 2346 3064 4462 2910 3186 3161 1478 3167 M16182 GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-alpha production. 34/57 Gene Ontology BP GO:0032647 3.02446762727788e-06 3.90803884191168e-06 3330 2678.63636363636 2911 2.74951980472453e-07 973 2.18235671410151 -2.14319037369079 -1 14.1706820546946 3330 2911 2048 1845 3576 4145 3273 1328 973 2807 3229 3168 M13703 GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 33/45 Gene Ontology BP GO:0098815 7.96309307347781e-07 1.25303591717593e-06 4540 2530.63636363636 2912 7.2391781416279e-08 664 2.31436536373712 2.76725395326193 1 16.4167674673094 4538 664 1146 981 2912 3323 3466 4068 2017 1016 3706 3169 M14953 GO_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 32/46 Gene Ontology BP GO:0010226 6.94355313841459e-06 8.3787221869925e-06 4630 2746.18181818182 2913 6.3123409577088e-07 583 2.77876914153078 -1.90166142058353 -1 16.9583937531843 4627 2913 1315 1976 3830 4563 4081 583 620 2543 3157 3170 M16035 GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION.html Any process that modulates the frequency, rate or extent of protein polyubiquitination. 16/20 Gene Ontology BP GO:1902914 3.96356168082421e-06 5.0047360925034e-06 485 2625.72727272727 2913 3.6032443833364e-07 481 1.59099849568694 -1.52426889360171 -1 10.0962244650091 481 3566 2913 3525 3658 1999 1271 3394 2598 3239 2239 3171 M15736 GO_HEXOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 174/228 Gene Ontology BP GO:0019318 5.23114157206099e-07 9.15400591756291e-07 2980 2848.54545454545 2915 4.75558437810715e-08 1617 1.8107243887011 -1.84613609920539 -1 13.1204208696456 2980 2804 2915 2927 2613 3667 3258 1617 2709 3019 2825 3172 M13274 GO_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. 19/19 Gene Ontology BP GO:0046931 1.0207280717453e-06 1.51111922298151e-06 1260 2425.90909090909 2917 9.27935041209147e-08 96 1.86146694557464 1.62932314497324 1 13.0009144222429 1259 2994 2917 3184 3103 1947 1322 4060 96 3256 2547 3173 M10935 GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 24/26 Gene Ontology BP GO:0071498 6.92464793093608e-05 7.48441041176436e-05 3050 2899.36363636364 2918 6.29533263499176e-06 2009 2.07564394806387 -2.2200169392249 -1 10.2540547529641 2993 3761 2588 3048 4273 3048 2009 2918 2346 2509 2400 3174 M14500 GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. 67/83 Gene Ontology BP GO:1901292 1.54620104975242e-08 2.43880457101628e-07 3390 2878.54545454545 2918 1.40563732783583e-09 7 1.90422048762787 1.62614884722985 1 15.1261037418381 3386 2856 2565 4103 7 3034 2918 4428 2868 1240 4259 3175 M14124 GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. 30/30 Gene Ontology BP GO:0032469 8.04882016294914e-07 1.26270032564999e-06 2955 2771.90909090909 2919 7.31711191605043e-08 2034 1.3324139356678 -1.29241820912262 -1 9.40231233267444 2034 2925 3475 2323 2919 2838 2396 2952 2524 2954 3151 3176 M10730 GO_NADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. 32/41 Gene Ontology BP GO:0006739 6.44051291898124e-06 7.81630323735517e-06 1300 2693.27272727273 2921 5.85502888517992e-07 1297 1.67774507746311 -1.63030887994315 -1 10.2594510138905 1297 2921 3092 3176 3808 2398 2329 1736 3764 3159 1946 3177 M13379 GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 13/15 Gene Ontology BP GO:0009113 7.48322530115264e-07 1.18953415131529e-06 1455 2977.45454545455 2921 6.8029344059523e-08 1184 0.717993526387814 0.659596641748036 1 5.04162622527299 1455 1184 3788 4184 2883 2168 2921 2608 4217 4306 3038 3178 M14285 GO_REGULATION_OF_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACROSOME_REACTION.html Any process that modulates the frequency, rate or extent of the acrosome reaction. 8/28 Gene Ontology BP GO:0060046 5.93038733056558e-07 1.00671624403946e-06 3285 2994.45454545455 2921 5.93038891319339e-08 1535 3.97010217263906 3.98438272278435 1 28.6916701655701 3283 2741 4485 1535 2765 2921 2869 3668 3310 1585 3777 3179 M14526 GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 146/175 Gene Ontology BP GO:0090263 8.06718118836104e-07 1.26513630163276e-06 1425 2793.27272727273 2921 7.33380376956151e-08 1421 1.66935801263408 1.95790379795275 1 11.804338279746 1421 4127 3038 2824 2921 2276 3043 2418 2947 3370 2341 3180 M11671 GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. 22/28 Gene Ontology BP GO:0044788 4.30487737404503e-07 8.02186400537907e-07 3215 2713.18181818182 2922 3.91352565127954e-08 698 2.6263795470373 -3.57324256514685 -1 19.2591147295286 3213 4003 2476 2922 2448 3923 3546 1238 698 3265 2113 3181 M12148 GO_POLYSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 23/33 Gene Ontology BP GO:0000272 0.00191954934733947 0.00196949572506517 1400 2924.72727272727 2922 0.000174656931449437 966 1.14257847318191 0.831608921158414 1 3.63578727512936 1398 3537 3616 3980 4519 1810 966 2672 2453 4299 2922 3182 M12255 GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 17/18 Gene Ontology BP GO:0042559 3.11248501300351e-07 6.41665607687432e-07 2175 2998.63636363636 2922 2.82953223031579e-08 2172 1.22843516031097 1.25528578519399 1 9.09731436934667 2172 2210 3430 4321 2198 2922 2779 2380 3765 3375 3433 3183 M10581 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. 31/36 Gene Ontology BP GO:2000108 2.73337681945834e-06 3.56257768653772e-06 3400 2693.45454545455 2923 2.484891105029e-07 558 2.53858640760264 -2.46730418504401 -1 16.6239954982383 3396 2923 1561 2133 3540 3301 2008 4288 558 2747 3173 3184 M13719 GO_MALE_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS_I.html A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. 19/129 Gene Ontology BP GO:0007141 1.91872314779095e-06 2.60058805903621e-06 1005 2518.90909090909 2923 1.74429529200128e-07 554 1.63778144233481 1.79272530228773 1 10.9592692537071 1002 3786 2959 3527 3402 997 554 2063 4383 2923 2112 3185 M10624 GO_RESPONSE_TO_STEROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 534/831 Gene Ontology BP GO:0048545 6.41046995819108e-08 4.02645553947883e-07 3780 2580.63636363636 2924 6.41047014311465e-09 73 2.2293927320523 2.24315416028701 1 17.1395874745594 3779 1441 4252 73 576 2924 4241 4477 2418 244 3962 3186 M10496 GO_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. 667/931 Gene Ontology BP GO:0043408 8.79737189744423e-08 4.02645553947883e-07 3565 2645.63636363636 2925 8.79737224571612e-09 237 1.98159673364432 -1.78577797248661 -1 15.2230863306387 3562 1402 4246 1117 966 3768 2925 4498 2825 237 3556 3187 M10583 GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 4/13 Gene Ontology BP GO:0010455 9.54360877979938e-05 0.000102381975713223 3740 3128.54545454545 2925 9.54401866668277e-06 1945 2.22226125081474 -2.51902324531377 -1 10.6199529381419 3739 2316 4248 2925 4320 3961 1945 3107 2778 2265 2810 3188 M13804 GO_EPIBOLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIBOLY.html The expansion of one cell sheet over other cells or yolk. 47/53 Gene Ontology BP GO:0090504 1.28831926303912e-05 1.49527301843876e-05 2925 2600.63636363636 2925 1.17120618863114e-06 405 2.79425262753736 2.53475125316786 1 16.2034069493333 2925 1912 405 554 3982 3782 4619 4451 986 938 4053 3189 M10123 GO_SINGLE_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_FERTILIZATION.html The union of male and female gametes to form a zygote. 76/166 Gene Ontology BP GO:0007338 2.99610927842087e-06 3.87354722770001e-06 2670 2977.81818181818 2929 2.72373941703052e-07 2260 2.17745925115196 -1.9597573305066 -1 14.1487890265287 2670 2847 2467 2923 3574 3060 3252 3467 2260 2929 3307 3190 M14038 GO_RESPONSE_TO_NICOTINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NICOTINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. 44/72 Gene Ontology BP GO:0035094 2.05123542053579e-07 5.00119458251237e-07 4270 2557.72727272727 2930 1.86475964708077e-08 534 2.43557395166768 2.60769996839034 1 18.4569035149177 4268 534 692 1823 1829 3626 2930 3734 3570 742 4387 3191 M12213 GO_RESPONSE_TO_GLUCAGON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GLUCAGON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 48/61 Gene Ontology BP GO:0033762 6.69784030827968e-08 4.02645553947883e-07 3595 2719.72727272727 2931 6.08894592017602e-09 515 1.86951700249321 -1.77079542895174 -1 14.3562404802558 3592 1930 2072 3173 515 3491 2113 2973 2931 2604 4523 3192 M10149 GO_LABYRINTHINE_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_DEVELOPMENT.html The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. 48/64 Gene Ontology BP GO:0060711 5.43084651469272e-08 4.02645553947883e-07 2255 2568 2932 4.93713331705161e-09 318 1.77142655736576 -1.97591099269808 -1 13.597590415274 2253 3690 2932 3562 318 2656 3555 1234 2964 3705 1379 3193 M11301 GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0033865 9.62314079511266e-07 1.44907683235143e-06 2100 2727.18181818182 2932 8.74831364038737e-08 1513 1.56633377043072 -1.71240506071111 -1 10.957802923624 2097 2932 3212 4118 3052 2228 2268 1513 3012 2950 2617 3194 M14052 GO_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G2_M_PHASE_TRANSITION.html The cell cycle process by which a cell in G2 phase commits to M phase. 186/243 Gene Ontology BP GO:0044839 8.17246849338393e-07 1.27820154284758e-06 420 2346.90909090909 2932 7.42951957205464e-08 420 1.48341900142102 1.63564554735583 1 10.4700563905244 420 3643 3838 3565 2932 804 732 1151 2938 3931 1862 3195 M10946 GO_PEPTIDYL_SERINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_SERINE_MODIFICATION.html The modification of peptidyl-serine. 177/216 Gene Ontology BP GO:0018209 1.27633583884865e-07 4.17034908558357e-07 3190 2700.90909090909 2933 1.16030537535966e-08 1313 1.72693523654451 2.05306860835479 1 13.2216367600204 3190 1714 2933 2316 1313 3258 3633 3223 1990 2770 3370 3196 M12620 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0034032 9.62314079511266e-07 1.44907683235143e-06 2100 2734.72727272727 2933 8.74831364038737e-08 1585 1.56633377043072 -1.71240506071111 -1 10.957802923624 2098 2933 3213 4119 3053 2229 2269 1585 3013 2952 2618 3197 M13130 GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0033875 9.62314079511266e-07 1.44907683235143e-06 2100 2719.36363636364 2934 8.74831364038737e-08 1406 1.56633377043072 -1.71240506071111 -1 10.957802923624 2099 2934 3214 4120 3054 2230 2270 1406 3014 2953 2619 3198 M13490 GO_INOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. 11/13 Gene Ontology BP GO:0006020 2.48584643541855e-07 5.59143257290898e-07 3060 2633.81818181818 2934 2.25986065118354e-08 291 1.51619048297338 -1.91537270422391 -1 11.3620636748888 3058 3079 2934 3185 2006 3387 2681 2807 291 3343 2201 3199 M15874 GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 45/58 Gene Ontology BP GO:0072523 1.9556998543288e-07 4.93246485651519e-07 4440 3053.45454545455 2935 1.77790911652877e-08 1516 1.80508159221329 1.55653906576042 1 13.6654674544155 4440 2507 2650 3685 1766 4619 3980 1652 2935 1516 3838 3200 M11042 GO_POSITIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOR_SIGNALING.html Any process that activates or increases the frequency, rate or extent of TOR signaling. 29/31 Gene Ontology BP GO:0032008 2.51641172063879e-07 5.62115397797997e-07 2570 2707.18181818182 2937 2.28764728042902e-08 423 1.58514084412921 -0.869936012809711 -1 11.8790337860125 2568 2948 3242 4187 2022 1336 423 3477 2503 4136 2937 3201 M14247 GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 15/27 Gene Ontology BP GO:0071360 2.22047076823273e-06 2.95702646954404e-06 1580 2576.18181818182 2937 2.0186118266981e-07 1067 1.6282718335521 -1.60440818618333 -1 10.7851868741085 1580 3045 2937 3790 3463 1727 1067 1606 3975 3471 1677 3202 M12669 GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. 16/21 Gene Ontology BP GO:0046500 2.68095843572138e-05 3.00156390794312e-05 2405 2839.90909090909 2938 2.43726464264241e-06 572 2.99377674288896 -3.76129886160721 -1 16.2720543462585 2401 4556 3397 4144 4132 2938 1731 572 1241 4071 2056 3203 M14195 GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT.html The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. 6/12 Gene Ontology BP GO:0043369 0.00538111021856281 0.00547644484841923 1960 3091.09090909091 2938 0.000539418515670429 1272 1.5604747587308 -1.5604747587308 -1 4.16502436814349 1956 4108 4480 3966 4635 2412 1272 1900 4541 2938 1794 3204 M10843 GO_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. 27/41 Gene Ontology BP GO:0033233 1.14496336199398e-05 1.33789917713661e-05 2595 3087.09090909091 2939 1.04088120078235e-06 2294 1.57197392408118 -1.75146947109717 -1 9.16239893387913 2591 3268 3093 2593 3960 2939 2359 4180 2776 3905 2294 3205 M13615 GO_DIOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. 10/12 Gene Ontology BP GO:0034311 0.000239806336088771 0.000252333532750124 2285 2753.09090909091 2939 2.18029526963416e-05 1211 1.40675138215637 -1.44446769112057 -1 6.01843912236733 2282 3596 3059 2939 4404 3111 2640 2317 1534 3191 1211 3206 M14246 GO_OXALATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALATE_TRANSPORT.html The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. 6/12 Gene Ontology BP GO:0019532 0.00027167585692199 0.000284965681302529 2095 3110.54545454545 2939 2.71709076134932e-05 1371 1.71624802941838 -1.73455647400617 -1 7.25556624609497 2091 4330 4483 3940 4424 1952 1828 1371 4267 2939 2591 3207 M11418 GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. 16/21 Gene Ontology BP GO:0019359 8.2784502078174e-07 1.29000766299311e-06 2440 2575.90909090909 2941 7.52586665722137e-08 659 2.00339072003506 -2.20040578538785 -1 14.1664611195627 2437 1084 2544 3387 2941 3103 3557 2984 3227 2412 659 3208 M16385 GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. 16/21 Gene Ontology BP GO:0019363 8.2784502078174e-07 1.29000766299311e-06 2440 2579.63636363636 2942 7.52586665722137e-08 660 2.00339072003506 -2.20040578538785 -1 14.1664611195627 2438 1085 2545 3388 2942 3104 3558 3004 3228 2424 660 3209 M16460 GO_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERAD_PATHWAY.html Any process that modulates the frequency, rate or extent of ERAD pathway. 36/37 Gene Ontology BP GO:1904292 4.37182699543208e-06 5.48748610999338e-06 2725 3048.90909090909 2943 3.9743960755682e-07 2012 1.45966644293143 -1.13413728863077 -1 9.18371421615899 2721 2012 3488 2143 3683 2943 2417 4499 3403 4014 2215 3210 M11344 GO_THYROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. 9/17 Gene Ontology BP GO:0042403 1.25552595057777e-05 1.46122117259589e-05 2945 2828.36363636364 2944 1.25553304418853e-06 1092 2.58284285845073 -2.90085130306673 -1 15.0009381600817 2944 3091 4294 2867 3999 3554 1901 1092 2834 1330 3206 3211 M12785 GO_PEPTIDYL_THREONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_THREONINE_MODIFICATION.html The modification of peptidyl-threonine. 79/87 Gene Ontology BP GO:0018210 1.54787469932598e-07 4.4077484553022e-07 4365 3089.09090909091 2945 1.40715891657388e-08 1334 1.74687077007471 2.01925404967151 1 13.3246566374131 4363 1854 2727 2324 1541 3686 4428 4368 1334 2945 4410 3212 M15344 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. 17/31 Gene Ontology BP GO:0035235 1.72083849242414e-06 2.36475531755745e-06 3965 2778.27272727273 2945 1.56439985314937e-07 806 2.02971549024922 1.73442902251675 1 13.7078921480533 3965 1007 1376 3164 3355 2945 4379 4194 2543 806 2827 3213 M11357 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. 30/69 Gene Ontology BP GO:0002716 8.85122368980555e-06 1.05224179429395e-05 1715 3077.45454545455 2946 8.04659936453483e-07 1715 1.46316342262893 -1.00822672986662 -1 8.70563749425345 1715 2008 2512 2946 3887 2915 4230 3695 4175 2309 3460 3214 M12601 GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 567/886 Gene Ontology BP GO:0032870 5.60724937382431e-08 4.02645553947883e-07 3495 2465.45454545455 2946 5.60724951530992e-09 429 1.99606677952412 -1.8940862641419 -1 15.3350004037447 3494 1426 4376 529 429 3389 2946 3619 2200 1448 3264 3215 M14306 GO_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JNK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. 203/282 Gene Ontology BP GO:0046328 7.15246493915556e-07 1.14953625930237e-06 3080 3055.45454545455 2946 6.50224296773556e-08 2273 1.68892167176974 -1.49223536463202 -1 12.0288842390591 3078 2791 2837 3085 2853 2901 2273 4120 3523 2946 3203 3216 M15795 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY.html Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. 30/69 Gene Ontology BP GO:0045953 8.85122368980555e-06 1.05224179429395e-05 1720 3079.27272727273 2947 8.04659936453483e-07 1716 1.46316342262893 -1.00822672986662 -1 8.70563749425345 1716 2009 2513 2947 3888 2916 4231 3703 4176 2312 3461 3217 M10665 GO_KERATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 31/38 Gene Ontology BP GO:0042339 2.82392768837607e-08 3.68884365916242e-07 3970 2448.36363636364 2951 2.56720702238555e-09 52 2.05051646583004 2.45564190144419 1 15.8504413595058 3968 678 1011 3132 52 3807 4649 2073 2951 544 4067 3218 M12374 GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. 27/37 Gene Ontology BP GO:0033081 1.55800583690361e-06 2.1633545685206e-06 4375 2999.18181818182 2951 1.41636994569114e-07 1331 2.37448006711244 2.56864718737812 1 16.1647986521862 4371 2951 1940 2771 3319 4544 3138 4519 1331 2554 1553 3219 M12392 GO_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that modulates the frequency, rate or extent of thymocyte aggregation. 27/37 Gene Ontology BP GO:2000398 1.55800583690361e-06 2.1633545685206e-06 4375 3000.18181818182 2952 1.41636994569114e-07 1332 2.37448006711244 2.56864718737812 1 16.1647986521862 4372 2952 1941 2772 3320 4545 3139 4520 1332 2555 1554 3220 M15865 GO_GERM_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. 195/412 Gene Ontology BP GO:0007281 7.90518244247923e-08 4.02645553947883e-07 2820 2789.09090909091 2954 7.18652975139396e-09 710 1.68795048179687 1.69209226364452 1 12.9519706500412 2668 3426 3028 2954 710 2819 2820 3786 3032 2321 3116 3221 M14168 GO_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING.html Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. 179/252 Gene Ontology BP GO:0016458 8.4192759297428e-07 1.30626511840924e-06 2085 3094.90909090909 2955 7.65389013795812e-08 1353 1.08902711262383 1.08487424017455 1 7.64662019613927 2082 4354 4166 4615 2955 1680 1808 1353 4199 4517 2315 3222 M14109 GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. 151/183 Gene Ontology BP GO:0072331 8.43513011239551e-07 1.3078527295227e-06 2555 2769.90909090909 2957 7.66830304232063e-08 1437 1.81652041316983 1.86978184442547 1 12.8223444224534 2551 3650 3263 3475 2957 1437 2173 2508 2966 3830 1659 3223 M15517 GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA.html Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. 29/32 Gene Ontology BP GO:0060330 3.31750217689918e-06 4.26182706491217e-06 1355 2819.18181818182 2959 3.01591561777773e-07 969 1.6315592867931 -1.37753593817254 -1 10.4939423301119 1351 3982 3578 2609 3598 1743 969 2959 3913 3656 2653 3224 M16371 GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 1557/2142 Gene Ontology BP GO:0051174 8.44023347487833e-08 4.02645553947883e-07 3815 2868.72727272727 2960 8.44023379544728e-09 257 1.99015439769209 2.1780509240378 1 15.2892729238129 3814 1307 4619 2827 916 2960 4591 3761 2706 257 3798 3225 M12923 GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rac protein signal transduction. 19/20 Gene Ontology BP GO:0035020 1.81438358334444e-06 2.47430445876368e-06 2380 2870.81818181818 2961 1.64944098154932e-07 1597 1.52342764220282 -1.49745874995133 -1 10.2267086428925 2376 2641 2961 2326 3383 3208 1597 3819 2335 3255 3678 3226 M14016 GO_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MATURATION.html Any process that modulates the frequency, rate or extent of protein maturation. 81/138 Gene Ontology BP GO:1903317 5.77439435016183e-08 4.02645553947883e-07 4130 2506.54545454545 2961 5.24944954702161e-09 223 2.67805228797303 -2.94836403046843 -1 20.6096053831511 4129 223 571 2366 372 3907 4602 3441 3279 1721 2961 3227 M16065 GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. 24/26 Gene Ontology BP GO:0016601 8.41473616182507e-08 4.02645553947883e-07 3740 2738.63636363636 2961 7.64976043970788e-09 794 1.27630567471464 -0.938779898034844 -1 9.76823181353578 3738 2075 3356 2961 794 3133 2169 2495 1906 3463 4035 3228 M10119 GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that stops or reduces the activity of a phosphoprotein phosphatase. 17/18 Gene Ontology BP GO:0032515 3.43046907221499e-05 3.81226954693489e-05 2725 2762.72727272727 2963 3.11865687711678e-06 427 1.49901830996795 -1.86801262515914 -1 7.90795316013851 2725 3025 3176 3520 4291 2568 1591 427 2963 3692 2412 3229 M12597 GO_DNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS.html The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 26/30 Gene Ontology BP GO:0006308 7.86890244574957e-07 1.24115264678213e-06 2945 3029.45454545455 2963 7.15355023661766e-08 377 1.29966341801723 -1.62694751819546 -1 9.18042376484247 2942 3746 3685 4151 2903 4646 2963 1113 2949 3849 377 3230 M14885 GO_LATERAL_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. 26/49 Gene Ontology BP GO:0021670 2.60488514606908e-07 5.69306274526043e-07 2800 3263.18181818182 2963 2.36807768590692e-08 2068 1.93779174736116 1.96743601173308 1 14.5317647766459 4530 2963 2345 3460 2068 4541 3538 2799 2350 2800 4501 3231 M15242 GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. 20/29 Gene Ontology BP GO:2000178 8.99173219714891e-08 4.02645553947883e-07 3305 2763.90909090909 2963 8.17430233150418e-09 882 1.57446603845265 1.5753169092888 1 12.074260489733 3302 2638 2963 1868 882 2645 3387 1897 3168 3677 3976 3232 M16360 GO_CELLULAR_GLUCURONIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCURONIDATION.html The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. 4/23 Gene Ontology BP GO:0052695 1.2718876358971e-05 1.47841448159611e-05 2965 2537.45454545455 2963 1.27189491559746e-06 200 5.75404203130745 5.24432725546432 1 33.5100591333337 2963 1292 4617 443 4002 3152 3771 2114 200 2270 3088 3233 M15791 GO_RRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. 27/28 Gene Ontology BP GO:0000154 1.24533077052006e-05 1.45044407389983e-05 475 2528.63636363636 2964 1.13212529080756e-06 57 0.88989480416236 0.821585702669008 1 5.10441101129384 473 2964 3940 4366 3967 301 57 1477 4303 4183 1784 3234 M11340 GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. 21/29 Gene Ontology BP GO:0095500 1.01484493428618e-06 1.50576322679643e-06 4180 2974.09090909091 2965 9.22586729479548e-08 1203 2.15158966516786 -1.48682432676844 -1 15.0472576915069 4177 2151 2491 3401 3091 4230 2965 2582 1203 2832 3592 3235 M12359 GO_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 537/935 Gene Ontology BP GO:0034220 7.12676732400536e-10 1.51419398897703e-08 3995 2713.09090909091 2965 7.12676732629093e-11 128 2.31982283024852 -2.14061056263257 -1 21.8362276941052 3994 1424 4363 2634 843 4357 3644 2965 1454 128 4038 3236 M10608 GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-10 production. 31/70 Gene Ontology BP GO:0032653 2.96511547725809e-07 6.18962867459932e-07 3490 2936.36363636364 2966 2.69555988808221e-08 1646 2.35544876763048 -2.49386846113753 -1 17.5825626145797 3487 3721 1646 2966 2170 3806 4464 2487 2322 2121 3110 3237 M11878 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION.html Any signal transduction that is involved in cellular response to ammonium ion. 21/29 Gene Ontology BP GO:1903831 1.01484493428618e-06 1.50576322679643e-06 4180 2968.81818181818 2966 9.22586729479548e-08 1204 2.15158966516786 -1.48682432676844 -1 15.0472576915069 4178 2152 2492 3402 3092 4231 2966 2513 1204 2834 3593 3238 M12189 GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 21/29 Gene Ontology BP GO:1905145 1.01484493428618e-06 1.50576322679643e-06 4180 3005.36363636364 2967 9.22586729479548e-08 1205 2.15158966516786 -1.48682432676844 -1 15.0472576915069 4179 2153 2493 3403 3093 4232 2967 2904 1205 2836 3594 3239 M16462 GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT.html The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. 142/166 Gene Ontology BP GO:0030705 2.6663148865459e-07 5.75701307057915e-07 3895 2867.72727272727 2967 2.42392291790273e-08 1480 1.51413821685712 1.68579770393202 1 11.3233362068119 2166 3894 3742 4320 2095 1480 2086 2967 3224 3892 1679 3240 M13242 GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. 21/29 Gene Ontology BP GO:0007213 1.01484493428618e-06 1.50576322679643e-06 4180 2993 2968 9.22586729479548e-08 1206 2.15158966516786 -1.48682432676844 -1 15.0472576915069 4180 2154 2494 3404 3094 4233 2968 2757 1206 2838 3595 3241 M14251 GO_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 21/29 Gene Ontology BP GO:1905144 1.01484493428618e-06 1.50576322679643e-06 4185 2997.54545454545 2969 9.22586729479548e-08 1207 2.15158966516786 -1.48682432676844 -1 15.0472576915069 4181 2155 2495 3405 3095 4234 2969 2797 1207 2839 3596 3242 M15668 GO_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_RESORPTION.html The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. 30/39 Gene Ontology BP GO:0045453 2.57688544373573e-05 2.89200385183366e-05 1285 2706.72727272727 2969 2.34265057053448e-06 1121 1.45403534964969 -1.54012416770653 -1 7.87855343661039 1283 3509 2969 3041 4122 1758 1121 2224 4570 3223 1954 3243 M16764 GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that modulates the frequency, rate or extent of response to reactive oxygen species. 37/43 Gene Ontology BP GO:1901031 8.58397749174267e-07 1.32695173651424e-06 4080 3054 2969 7.80361894640696e-08 1252 2.16987984940737 2.22339977095784 1 15.3201215458982 3291 2902 2235 2112 2969 3576 4077 4079 1252 2535 4566 3244 M13057 GO_OVULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION.html The release of a mature ovum/oocyte from an ovary. 24/28 Gene Ontology BP GO:0030728 1.78126257124132e-06 2.43914501000173e-06 3245 2652.54545454545 2970 1.61933092133506e-07 1158 2.86432162027069 -2.08632161163539 -1 19.3402289416229 3242 2970 1158 1810 3367 2885 2019 3631 3205 1797 3094 3245 M15706 GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION.html Signal transduction in which the initial step occurs in a postsynapse. 21/29 Gene Ontology BP GO:0098926 1.01484493428618e-06 1.50576322679643e-06 4185 2999.36363636364 2970 9.22586729479548e-08 1208 2.15158966516786 -1.48682432676844 -1 15.0472576915069 4182 2156 2496 3406 3096 4235 2970 2805 1208 2842 3597 3246 M15859 GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). 14/19 Gene Ontology BP GO:0048016 4.3297070008154e-07 8.04557774552478e-07 3535 3000.81818181818 2970 3.93609804811185e-08 1952 1.80176924093492 -1.59594742398013 -1 13.1771677573218 3532 2223 2405 2905 2455 3309 1952 3779 3253 2970 4226 3247 M14703 GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. 5/18 Gene Ontology BP GO:0045653 1.63954993619439e-05 1.87902114608682e-05 3275 3055 2971 1.63956203287797e-06 1287 1.70898895813716 -2.71478816811373 -1 9.66510095426475 3271 1287 4513 2971 4058 4637 2175 2525 2242 2620 3306 3248 M13670 GO_PIGMENT_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. 24/29 Gene Ontology BP GO:0048753 1.63266518757471e-06 2.25691952400033e-06 665 2410.27272727273 2972 1.48424218110031e-07 403 1.03660696008837 -1.02260063294878 -1 6.97586802367152 661 2972 3777 4336 3336 458 403 999 4319 3925 1327 3249 M10354 GO_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_GASEOUS_EXCHANGE.html The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. 47/68 Gene Ontology BP GO:0007585 6.10412296425742e-06 7.45472025004981e-06 4110 2802.81818181818 2974 5.54921809166455e-07 505 2.4230694457412 -1.85506271872279 -1 14.9231449638333 4107 3484 1525 3159 3782 4518 2272 505 2974 2006 2499 3250 M16013 GO_CELLULAR_COMPONENT_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY.html A cellular process that results in the breakdown of a cellular component. 552/744 Gene Ontology BP GO:0022411 1.40323205567786e-07 4.27026733490458e-07 2975 3156.90909090909 2974 1.40323214428558e-08 1537 1.88169049632698 2.04443204144696 1 14.3922887636416 2974 4614 4586 3709 1537 2381 2676 2355 2314 4240 3340 3251 M11470 GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 23/27 Gene Ontology BP GO:0009067 4.03451160964348e-06 5.08742073703824e-06 1565 2738.63636363636 2976 3.66774455311627e-07 1563 1.27112745852299 1.44808998484725 1 8.03473366573708 1563 2976 3427 3249 3664 2119 2579 1609 2997 3394 2548 3252 M12794 GO_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. 232/316 Gene Ontology BP GO:0019882 3.65407625455149e-07 7.12292283721328e-07 2980 3187.09090909091 2977 3.32188805588467e-08 2075 1.51829562876636 -1.42262587253911 -1 11.184930672529 2977 2784 3611 2075 2332 4394 4389 3954 2420 3289 2833 3253 M12191 GO_DNA_CONFORMATION_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CONFORMATION_CHANGE.html A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. 234/419 Gene Ontology BP GO:0071103 2.30065334636933e-06 3.04810365052862e-06 175 2029.81818181818 2978 2.09150522934963e-07 175 1.64979646311774 1.82553669650983 1 10.9028340464939 175 3420 3652 2994 3478 188 300 1099 3069 2978 975 3254 M10984 GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 118/163 Gene Ontology BP GO:0007249 2.08477645080363e-06 2.79955694822202e-06 3440 2338.18181818182 2979 1.89525311490355e-07 345 1.80024106675697 -1.77519244700485 -1 11.9868769071769 345 3440 2979 3776 3436 1300 812 1343 3206 3245 1838 3255 M12544 GO_IN_UTERO_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IN_UTERO_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. 334/428 Gene Ontology BP GO:0001701 1.35701272433124e-07 4.23886744058351e-07 4320 3054.81818181818 2979 1.23364800730459e-08 1386 1.73636927659519 1.70087307694775 1 13.2795651084599 4318 2342 2894 1610 1386 4645 4097 3871 1991 2979 3470 3256 M10802 GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM.html The growth process in which a branch increases in length from its base to its tip. 19/23 Gene Ontology BP GO:0060602 1.67348607900785e-06 2.30527467573347e-06 4270 2847 2981 1.52135213817186e-07 995 1.99894630495452 -1.7891407361428 -1 13.525274830991 4267 995 2282 1031 3346 4559 3945 2981 1877 2109 3925 3257 M10840 GO_ICOSANOID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_TRANSPORT.html The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. 20/31 Gene Ontology BP GO:0071715 8.74603419981416e-07 1.34574395276902e-06 3535 2810.63636363636 2981 7.95094334252348e-08 726 2.42966525029757 -2.09575826874909 -1 17.1486791918472 3533 2121 868 1957 2981 4592 4412 2445 4063 726 3219 3258 M11053 GO_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 321/412 Gene Ontology BP GO:0051186 1.95810567905694e-07 4.93246485651519e-07 1390 3023 2981 1.78009623030707e-08 1389 1.5383046519081 -1.57420002984529 -1 11.6306018960676 1389 4119 3988 4328 1768 2825 3076 1834 2981 4312 2633 3259 M11424 GO_RESPONSE_TO_COPPER_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COPPER_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. 33/42 Gene Ontology BP GO:0046688 1.36771439801889e-05 1.58111182459178e-05 4260 3138.81818181818 2981 1.2433844554674e-06 1357 2.27891278054629 -2.29788258551646 -1 13.1292345128999 4258 3507 2488 2664 3997 3967 2931 2172 1357 2981 4205 3260 M11459 GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. 22/32 Gene Ontology BP GO:0065005 4.42767078528802e-07 8.17030012087984e-07 3960 2945.27272727273 2982 4.02515606944672e-08 1396 1.85476904791523 -0.989882555481871 -1 13.5528222907076 3958 2982 3022 2977 2471 3278 1396 3651 1646 2961 4056 3261 M13716 GO_FATTY_ACID_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_TRANSPORT.html The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/31 Gene Ontology BP GO:1901571 8.74603419981416e-07 1.34574395276902e-06 3535 2813.81818181818 2982 7.95094334252348e-08 728 2.42966525029757 -2.09575826874909 -1 17.1486791918472 3534 2122 869 1958 2982 4593 4413 2469 4064 728 3220 3262 M14087 GO_RESPONSE_TO_VITAMIN_A http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_A.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. 18/32 Gene Ontology BP GO:0033189 1.64270012469729e-05 1.88216786018628e-05 4475 3119.45454545455 2983 1.49337490051782e-06 1846 2.59120691331808 2.09515481498846 1 14.7053119640734 4475 3308 1846 2511 4033 4005 3981 1993 2842 2337 2983 3263 M14232 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. 939/1312 Gene Ontology BP GO:1902533 3.41025723036169e-10 7.81671275510983e-09 3975 2670.63636363636 2984 3.41025723088503e-11 117 2.1016872666941 2.29606871446822 1 20.5031506866101 3975 1359 4481 729 942 3683 2984 4323 2603 117 4181 3264 M14546 GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of activated T cell proliferation. 16/28 Gene Ontology BP GO:0042104 8.15348567432251e-07 1.27651981300884e-06 2985 2932.63636363636 2984 7.41226245101068e-08 1226 2.08949499101611 -1.82681771931861 -1 14.7912855389725 2984 2203 1824 3699 2929 3951 3509 2682 3956 1226 3296 3265 M10356 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. 167/205 Gene Ontology BP GO:1903321 2.07570717475782e-07 5.02811604926545e-07 2815 3224.90909090909 2986 1.88700670054682e-08 1845 1.23909302415441 1.27218559535309 1 9.3358378938678 2811 4355 4099 4083 1845 1958 2322 2962 3659 4394 2986 3266 M16102 GO_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that modulates the frequency, rate or extent of muscle adaptation. 75/102 Gene Ontology BP GO:0043502 4.37848804890657e-08 4.02645553947883e-07 4410 2878.63636363636 2986 3.98044376004381e-09 170 1.80401495251191 1.67216946048214 1 13.8496352302726 4409 280 2268 2766 170 4468 3822 3448 2986 2444 4604 3267 M10629 GO_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 44/53 Gene Ontology BP GO:0070670 5.55800719062579e-06 6.85080360643417e-06 1920 3037.63636363636 2987 5.05274657476443e-07 1210 1.90112535721297 -1.767510968066 -1 11.7707876932683 1918 4186 2657 4170 3748 2411 1210 4053 4050 2987 2024 3268 M10944 GO_PEPTIDE_CROSS_LINKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CROSS_LINKING.html The formation of a covalent cross-link between or within protein chains. 47/103 Gene Ontology BP GO:0018149 4.25576482848718e-06 5.35335867719677e-06 1160 2562.63636363636 2987 3.86888460093187e-07 354 3.21645383189847 3.65548969252183 1 20.402531357519 1156 3482 354 2269 4024 2593 3493 3632 3532 667 2987 3269 M16851 GO_ESTROUS_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROUS_CYCLE.html A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. 16/25 Gene Ontology BP GO:0044849 1.48138781778906e-05 1.708700425427e-05 2625 2920.27272727273 2988 1.34672526629813e-06 1735 2.52500431912786 -2.57096633939519 -1 14.4552100214721 2622 4053 2218 2988 4008 3167 1847 3566 3046 2873 1735 3270 M13937 GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. 26/66 Gene Ontology BP GO:0002228 3.71773240380791e-06 4.72381454803883e-06 3540 3163.09090909091 2989 3.37976244212575e-07 2226 1.65029780742645 -0.997119423641156 -1 10.5264388869296 3538 2955 2845 3456 3636 3239 2989 2828 2226 2798 4284 3271 M15039 GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 55/65 Gene Ontology BP GO:0009066 1.01834171129246e-06 1.50950748093145e-06 2540 3108.45454545455 2990 9.25765620604929e-08 2401 1.46983778122678 1.38819116606212 1 10.2448488581711 2536 2481 3553 4475 3099 2401 2837 3516 2940 2990 3365 3272 M12551 GO_VESICLE_CYTOSKELETAL_TRAFFICKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_CYTOSKELETAL_TRAFFICKING.html The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. 49/56 Gene Ontology BP GO:0099518 5.66487750592426e-06 6.96766456121215e-06 1930 2928.81818181818 2991 5.14990190247364e-07 875 1.67523127580067 -1.46674644216987 -1 10.3450519024703 1927 4428 3462 4309 3757 2046 2991 2319 2239 3864 875 3273 M10807 GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 20/27 Gene Ontology BP GO:0009065 8.90397666990708e-07 1.36508083838806e-06 2895 2740.63636363636 2995 8.09452752143807e-08 929 2.27418683474856 -2.96358439178116 -1 16.0276763042745 2892 929 1483 3156 2995 3875 3744 3484 3970 1495 2124 3274 M12249 GO_EPITHELIAL_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_CELL_ADHESION.html The attachment of an epithelial cell to another epithelial cell via adhesion molecules. 20/22 Gene Ontology BP GO:0090136 2.59255105062051e-07 5.68211966016827e-07 2995 3142.54545454545 2995 2.35686486921377e-08 2063 1.92465103349984 1.6794679026105 1 14.4344675717261 3931 2991 2466 2995 2063 3672 4325 2095 3041 2647 4342 3275 M14806 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. 79/110 Gene Ontology BP GO:0008543 9.64234661917068e-08 4.02645553947883e-07 2180 2917.81818181818 2995 8.76577003798511e-09 959 1.59956226538999 2.09374104313394 1 12.2683594580073 2176 3457 2995 4334 959 2170 2505 4278 3057 3840 2325 3276 M11133 GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 20/125 Gene Ontology BP GO:0048385 1.82258718355982e-05 2.07600934274268e-05 1655 2528.45454545455 2996 1.65691116630467e-06 494 1.45437605801851 -1.79680946472713 -1 8.1336543918725 1651 2996 3205 3556 4060 1021 1147 1935 4079 3669 494 3277 M15079 GO_PROTEIN_K63_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. 44/59 Gene Ontology BP GO:0070534 1.48003754796841e-06 2.06991725599549e-06 2625 2953.27272727273 2996 1.34548958514203e-07 1752 1.17086664318962 -1.56057472571661 -1 7.94589722282318 2621 2511 3629 4168 3295 2996 3446 2388 2055 3625 1752 3278 M12270 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. 97/124 Gene Ontology BP GO:0090317 6.59843533469023e-08 4.02645553947883e-07 3660 2730.81818181818 2997 5.99857775690581e-09 494 1.80012849098976 -1.66235638244574 -1 13.819576601397 3659 2422 2997 3214 494 3666 2877 3751 1360 3613 1986 3279 M15986 GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. 10/14 Gene Ontology BP GO:0003417 5.04268521437369e-05 5.52605141367893e-05 2490 3031 2999 4.58436436633229e-06 1706 2.2694039539695 2.01473428528862 1 11.5824575094192 2488 3088 2567 2999 4219 2237 2945 1706 4135 3195 3762 3280 M13329 GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. 69/119 Gene Ontology BP GO:0002762 2.68338053469698e-06 3.50330236474328e-06 2170 2883.36363636364 3000 2.43943982515568e-07 881 2.05701123184186 -2.19379855448352 -1 13.4689848063653 2170 3916 2380 3767 3534 3000 2712 881 3257 3689 2411 3281 M10136 GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 239/337 Gene Ontology BP GO:0046394 1.01594117040164e-07 4.02645553947883e-07 4125 2640.18181818182 3001 9.23582924833577e-09 437 2.03766287518429 2.0138892924151 1 15.6567124791113 4122 1605 576 3125 1029 3892 4254 3001 2740 437 4261 3282 M12660 GO_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. 340/446 Gene Ontology BP GO:0097190 1.14770008366542e-07 4.07598035460087e-07 3175 2943 3003 1.04336376685351e-08 1192 1.80788132507963 -1.65071108447502 -1 13.8679302600742 3174 4342 3003 3283 1192 2914 2497 3900 2158 3434 2476 3283 M14763 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE.html Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. 18/43 Gene Ontology BP GO:0050884 4.00415683030117e-05 4.41815075442052e-05 3005 2951.90909090909 3003 3.64020882787907e-06 560 2.41749909232199 -2.10801916765172 -1 12.6291263904708 3990 3002 2105 2734 4184 3685 3003 560 1106 3456 4646 3284 M10574 GO_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_PROCESS.html Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. 1774/2967 Gene Ontology BP GO:0002376 1.67199745134882e-10 4.05178730846875e-09 3165 2561.45454545455 3004 1.67199745147462e-11 110 2.03463641816374 -1.95006048395596 -1 20.5479707970886 3164 1296 4247 1690 878 3759 3004 3901 2678 110 3449 3285 M12872 GO_PROTEIN_O_LINKED_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_FUCOSYLATION.html The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. 18/19 Gene Ontology BP GO:0036066 4.84061864363607e-06 6.03197604414532e-06 3860 3037.72727272727 3004 4.40057208581008e-07 1702 2.30269381234112 -2.3745936739715 -1 14.4327929227368 3857 3004 1702 2856 3710 4521 2241 3882 3173 2333 2136 3286 M15084 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 25/35 Gene Ontology BP GO:1902236 2.36124188491012e-06 3.12126661661557e-06 765 2421.45454545455 3004 2.14658583565036e-07 241 1.94865446467841 -1.69131655801182 -1 12.8722390471791 763 4230 3004 3311 3485 959 241 2251 4103 3287 1002 3287 M13085 GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION.html The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. 13/16 Gene Ontology BP GO:0071425 1.14516134170527e-07 4.07501813675178e-07 2980 2935.54545454545 3007 1.04105581937647e-08 1121 1.32158458361984 -1.48898065606085 -1 10.1101055851091 2979 4075 3311 4186 1188 3007 2499 2002 4316 3607 1121 3288 M15060 GO_COCHLEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_MORPHOGENESIS.html The process in which the cochlea is generated and organized. 24/37 Gene Ontology BP GO:0090103 9.09802070766549e-07 1.39024927266888e-06 3485 2800.36363636364 3007 8.27093133647394e-08 956 1.98628455920651 2.28401415655136 1 13.9665475319242 3484 3262 2044 2572 3007 2787 3233 3294 3885 956 2280 3289 M12765 GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive nitrogen species. 19/26 Gene Ontology BP GO:2001057 0.00212377058622112 0.00217711049519429 3010 3295.36363636364 3008 0.000193256685801013 2189 1.42132898601994 -1.69775361136624 -1 4.47309655183946 3008 2189 3005 3953 4521 3235 4015 2324 4464 2921 2614 3290 M13177 GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION.html A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. 16/20 Gene Ontology BP GO:0014829 1.77207910858342e-05 2.01996180603593e-05 4190 2817.90909090909 3009 1.61099398424848e-06 807 3.41379855726372 -2.42380171455104 -1 19.2795850682421 4187 3009 807 1781 4054 3555 3096 3991 1412 2414 2691 3291 M10826 GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 189/257 Gene Ontology BP GO:0046395 4.43112918721608e-07 8.17030012087984e-07 2200 2907.72727272727 3010 4.02830007246551e-08 2124 1.74692185926119 -1.76891976455397 -1 12.7587948654394 2200 2795 3010 2900 2473 3218 3855 2124 3181 3070 3159 3292 M15086 GO_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 17/21 Gene Ontology BP GO:0010463 1.0523972872751e-05 1.23656681254824e-05 2865 2695.72727272727 3010 9.56729383256153e-07 258 2.42879701209218 3.09621877949391 1 14.3130673001237 2862 3010 1922 2330 4017 3357 3628 258 1621 3379 3269 3293 M13128 GO_ORGANIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. 189/257 Gene Ontology BP GO:0016054 4.43112918721608e-07 8.17030012087984e-07 2205 2893.18181818182 3011 4.02830007246551e-08 1954 1.74692185926119 -1.76891976455397 -1 12.7587948654394 2201 2796 3011 2901 2474 3219 3856 1954 3182 3071 3160 3294 M10315 GO_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACTIVATION_CASCADE.html A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. 51/269 Gene Ontology BP GO:0072376 2.67595082392369e-07 5.77246137399951e-07 1535 2625.09090909091 3012 2.43268286310063e-08 472 3.16684764794941 -3.37537829437912 -1 23.7908867447685 1532 3208 472 4099 2097 3610 3012 3561 3540 1669 2076 3295 M15436 GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. 18/22 Gene Ontology BP GO:0044320 0.000143264801928431 0.000152090149069813 3075 2672.54545454545 3013 1.30249211122905e-05 1208 2.23690176589277 -2.28134658379913 -1 10.2256157787692 3072 3013 2076 1208 4357 3482 3965 1241 2593 3155 1236 3296 M11000 GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION.html The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. 25/26 Gene Ontology BP GO:0006271 0.000206422864523605 0.000217797185630008 180 2435.72727272727 3014 1.87674759483088e-05 102 1.20044901269264 1.24759934152761 1 5.21353059662576 177 3530 3555 3014 4391 545 102 1741 4182 3282 2274 3297 M14317 GO_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. 561/765 Gene Ontology BP GO:0005975 7.72039848895286e-08 4.02645553947883e-07 3015 2853.45454545455 3015 7.72039875717334e-09 803 1.82087316407774 -1.72339201216223 -1 13.9800198287244 3015 2765 4486 3134 803 3330 2888 2210 2008 3312 3437 3298 M11329 GO_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. 983/1254 Gene Ontology BP GO:0051338 1.09751737907249e-07 4.02645553947883e-07 3655 2989 3016 1.097517433277e-08 1248 1.84651520850355 1.97003153753391 1 14.1783402527435 3654 2321 4293 3016 1248 2238 3523 3752 2855 2215 3764 3299 M15474 GO_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of DNA replication. 174/211 Gene Ontology BP GO:0006275 9.22561971069179e-07 1.40559294413389e-06 1210 2664.72727272727 3018 8.38693052674911e-08 950 1.54869675259936 1.56305282416196 1 10.8580411639672 1209 3888 3684 3114 3018 1533 950 3090 1798 4149 2879 3300 M10998 GO_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. 109/161 Gene Ontology BP GO:0002573 1.49563480573564e-07 4.36901586057683e-07 3845 2792.54545454545 3019 1.35966809764908e-08 1493 2.01307179006873 2.01900570692857 1 15.3801875902791 3845 1831 1673 3019 1493 3572 4104 2755 3784 1575 3067 3301 M16239 GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. 636/1026 Gene Ontology BP GO:0045596 2.262545411376e-09 4.36830863034545e-08 3885 2494 3020 2.2625454136796e-10 68 2.23554607345331 2.51733560687498 1 19.7951583105637 3883 1407 4607 68 1048 3381 4480 3020 1856 138 3546 3302 M16536 GO_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 111/235 Gene Ontology BP GO:0042445 1.16552726430251e-07 4.08548528935279e-07 3025 2384.18181818182 3021 1.05957029640947e-08 789 2.1783661491208 -2.10273486035434 -1 16.7282861635767 3021 1825 789 3367 1212 3308 3095 2057 3285 837 3430 3303 M15553 GO_GMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GMP, guanosine monophosphate. 21/27 Gene Ontology BP GO:0046037 3.22997315991065e-06 4.15826294337374e-06 3670 3191 3025 2.93634354733533e-07 2058 1.54389070984574 1.80830891879386 1 9.94448777302922 3670 3284 3025 2774 3590 3627 4606 2901 2726 2840 2058 3304 M13163 GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY.html Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. 9/17 Gene Ontology BP GO:0006957 3.63595748793803e-05 4.02812147413706e-05 465 2464.18181818182 3027 3.63601698014885e-06 460 3.1968753805214 -3.1968753805214 -1 16.889001602373 461 3859 4413 3897 4292 1286 684 460 4197 3027 530 3305 M16972 GO_AMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 16/24 Gene Ontology BP GO:0009309 2.08916881344032e-06 2.80383688749288e-06 2580 2802.45454545455 3028 1.89924617942183e-07 1453 1.66009362924055 1.30057797973662 1 11.0443602094403 2578 3028 3032 3707 3437 2020 1453 3658 3474 2874 1566 3306 M12917 GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. 12/17 Gene Ontology BP GO:0006044 0.0124926947728409 0.0126558913080837 2220 3174.54545454545 3029 0.00114220033168345 2191 1.64547683235131 1.64747368433245 1 3.67354665855254 2219 4094 3333 3029 4572 2821 2788 3968 2409 3496 2191 3307 M10641 GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. 48/66 Gene Ontology BP GO:2000351 2.78979755597174e-07 5.94364836443979e-07 3880 2958 3030 2.53617991794835e-08 960 2.66764302523092 2.5393179601817 1 19.9834434937326 3877 3209 960 2668 2126 3419 4555 3030 2930 1363 4401 3308 M11769 GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. 300/373 Gene Ontology BP GO:0006520 7.33232533334719e-07 1.17176041696156e-06 3030 2961.81818181818 3030 6.6657525246553e-08 2092 1.73082968697858 1.62056718619727 1 12.3125095269153 3030 2349 3132 3366 2868 2702 3057 3482 2092 2859 3643 3309 M16829 GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). 21/71 Gene Ontology BP GO:0030520 1.87118462486467e-07 4.82197350765291e-07 3840 3053.09090909091 3031 1.7010770763783e-08 1721 1.70301778917067 -1.65137379519839 -1 12.9072314662378 3840 2619 3031 2899 1721 4600 3108 2933 1873 3448 3512 3310 M13813 GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. 11/19 Gene Ontology BP GO:0060575 0.00108623170187768 0.00111893648634865 3805 3097.54545454545 3032 9.87971264329576e-05 1863 1.47572875699052 1.76810881816271 1 5.16416437751915 3802 3385 2690 3250 4496 3032 2720 1866 4030 1863 2939 3311 M11343 GO_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_ARREST.html A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). 176/219 Gene Ontology BP GO:0007050 7.33392253748556e-08 4.02645553947883e-07 3470 2976.63636363636 3033 6.66720252906301e-09 621 1.80296873063104 2.01416030521086 1 13.8415435522618 3466 3886 3245 3033 621 2505 4054 4501 2284 2857 2291 3312 M12995 GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of cell junction assembly. 44/50 Gene Ontology BP GO:1901890 9.42773357422423e-07 1.42936605802755e-06 2280 2442.81818181818 3033 8.57067055847714e-08 497 2.28863869783626 2.60002375864105 1 16.0748660543232 2279 497 588 1009 3033 3324 4496 4098 3123 518 3906 3313 M12089 GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM.html The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 23/25 Gene Ontology BP GO:0003159 9.45528532430439e-07 1.43198214268385e-06 4310 2729.81818181818 3035 8.59571762550292e-08 266 1.63284131184371 1.42011839092214 1 11.4376274610267 4310 2106 2814 266 3035 4282 3368 4043 323 3096 2385 3314 M13927 GO_MATERNAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_BEHAVIOR.html Female behaviors associated with the care and rearing of offspring. 10/16 Gene Ontology BP GO:0042711 1.82487377556889e-05 2.07759669139272e-05 2630 3167.72727272727 3036 1.65898992077738e-06 2126 2.93160662092399 2.67212135123125 1 16.4985223055986 2628 4318 2829 3513 4062 2126 2487 3036 3630 3634 2582 3315 M10297 GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. 15/17 Gene Ontology BP GO:1904872 6.85289350812914e-05 7.41374412772027e-05 180 2375.09090909091 3037 6.23009725614022e-06 27 0.816760013279682 0.816760013279682 1 3.97656698392915 178 3037 3836 3072 4358 487 27 1118 4036 4204 1773 3316 M14645 GO_LEUKOCYTE_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CELL_CELL_ADHESION.html The attachment of a leukocyte to another cell via adhesion molecules. 255/415 Gene Ontology BP GO:0007159 8.71055801049717e-08 4.02645553947883e-07 3625 2451.54545454545 3037 7.91868941398019e-09 430 2.04467159514975 -1.7784412037207 -1 15.710919245635 3625 1585 430 718 846 4197 3615 4126 3037 468 4320 3317 M14830 GO_CELLULAR_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a cell. 7/16 Gene Ontology BP GO:0009992 4.39276095274877e-06 5.51078908415746e-06 3040 2650.45454545455 3037 4.39276963612987e-07 769 2.96073798084437 2.94384169705842 1 18.7272234442662 3037 1274 4519 1500 3709 3474 1987 4264 769 3166 1456 3318 M11892 GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. 290/400 Gene Ontology BP GO:1901565 9.45782916517166e-08 4.02645553947883e-07 3670 2571.81818181818 3038 8.59802688342275e-09 598 2.00851085861124 2.09948085282806 1 15.4312452662879 3668 1560 957 3645 940 3038 3909 3649 2464 598 3862 3319 M14404 GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. 15/17 Gene Ontology BP GO:1904874 6.85289350812914e-05 7.41374412772027e-05 180 2367.27272727273 3038 6.23009725614022e-06 28 0.816760013279682 0.816760013279682 1 3.97656698392915 179 3038 3837 3073 4359 488 28 1017 4037 4210 1774 3320 M10642 GO_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION.html A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 104/129 Gene Ontology BP GO:0006261 3.51043502980859e-05 3.89555311082742e-05 75 2294.27272727273 3039 3.19135549581522e-06 71 1.32478295219859 1.3624834677075 1 6.96178375419246 71 3172 3926 3039 4169 314 126 1510 3870 3136 1904 3321 M11032 GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 14/16 Gene Ontology BP GO:0071545 5.86760234645051e-06 7.19229550000901e-06 2495 2950.36363636364 3040 5.33419817813098e-07 1364 1.09181343617925 -1.10870092549705 -1 6.68822085384787 2493 3581 3596 3040 3767 2731 2277 1796 3835 3974 1364 3322 M11102 GO_PENTOSE_PHOSPHATE_SHUNT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_PHOSPHATE_SHUNT.html The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. 15/16 Gene Ontology BP GO:0006098 0.00063996864973417 0.000663053691207547 390 2428.09090909091 3043 5.81958990148711e-05 387 1.14831351726289 -1.05455965630729 -1 4.31117148439602 387 3043 3478 3251 4489 1077 545 1142 3984 3466 1847 3323 M12092 GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving guanosine-containing compounds (guanosines). 50/59 Gene Ontology BP GO:1901068 1.6382368902221e-07 4.50515144811078e-07 2910 3075.09090909091 3044 1.48930637473994e-08 1604 1.49650427142785 1.80902819553848 1 11.3829923142979 2906 2489 3044 4472 1604 2789 3319 3988 2700 3242 3273 3324 M12651 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate, or extent of leukocyte migration. 92/148 Gene Ontology BP GO:0002687 5.29155237347167e-08 4.02645553947883e-07 4645 2747.54545454545 3046 4.81050227340619e-09 284 2.65286226178114 2.60838829058432 1 20.4147809536917 4645 1845 312 2385 284 4478 3046 4335 3583 731 4579 3325 M15190 GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. 21/45 Gene Ontology BP GO:0042743 0.0108376242711957 0.0109916450199654 1560 2948.09090909091 3046 0.000990125784210741 644 1.48540008865964 -1.41801473358859 -1 3.41615341688013 1556 2987 3046 3700 4568 1845 644 2609 4295 3758 3421 3326 M13707 GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. 33/43 Gene Ontology BP GO:2000300 9.51136578630298e-07 1.43534740556727e-06 3290 3025 3047 8.64669990763635e-08 2027 1.55415797307704 -1.34847257426228 -1 10.8795937599823 3290 2027 3029 3719 3047 2895 2342 3135 3493 2983 3315 3327 M14150 GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The regulation of blood pressure mediated by detection of stimuli and a neurological response. 15/22 Gene Ontology BP GO:0001976 1.0905967642321e-06 1.59306681284276e-06 3995 3102.18181818182 3047 9.91452095335841e-08 1720 2.43400185511055 1.38268252928484 1 16.9637832278648 3991 3040 1720 2683 3151 4409 3047 2449 3735 2231 3668 3328 M15237 GO_MITOCHONDRIAL_GENOME_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_GENOME_MAINTENANCE.html The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. 30/31 Gene Ontology BP GO:0000002 1.28665870647524e-05 1.4944564400798e-05 1945 2752.63636363636 3047 1.16969657408568e-06 1119 1.90602118215085 2.21838883613667 1 11.0205191463851 1941 3731 3321 3047 3979 1241 1119 3515 1916 3877 2592 3329 M16094 GO_SERTOLI_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. 20/26 Gene Ontology BP GO:0060008 1.06619702787083e-06 1.5689483778251e-06 3050 2872.09090909091 3047 9.69270495079628e-08 2144 1.93073308380239 2.05138050389056 1 13.4504321619266 3047 3294 2504 3266 3125 3151 3008 2144 3090 2653 2311 3330 M11188 GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 15/17 Gene Ontology BP GO:0009129 1.75078129296984e-07 4.65466347597117e-07 2470 3074.54545454545 3048 1.59161948390793e-08 1669 1.15062961520656 1.18892239429216 1 8.70860875400775 2469 3048 3519 4327 1669 2672 2251 2949 3868 3793 3255 3331 M11381 GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 17/20 Gene Ontology BP GO:0090335 0.000919302793359322 0.000948661764803931 3050 3245.09090909091 3048 8.36079238739739e-05 1860 1.88843921966004 2.50231065407325 1 6.80093699025312 3048 4532 2952 3574 4485 2634 1860 2289 3709 3920 2693 3332 M10224 GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of cell cycle checkpoint. 40/42 Gene Ontology BP GO:1901976 2.71145853812785e-08 3.62131464781807e-07 3055 2669.45454545455 3049 2.46496233776915e-09 44 1.51491340183438 1.58504362840816 1 11.6980509957493 3054 3219 3285 2982 44 2859 1990 4608 1137 3137 3049 3333 M14708 GO_GLUTATHIONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. 53/71 Gene Ontology BP GO:0006749 9.47138571253068e-07 1.43271644084543e-06 4075 3110.72727272727 3049 8.61035435466432e-08 421 1.62809552528939 -1.81728284963943 -1 11.40364683548 4073 421 2890 3658 3040 3832 4250 2812 3049 2099 4094 3334 M16821 GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS.html The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. 50/72 Gene Ontology BP GO:0048701 6.69576129866224e-07 1.09432305313226e-06 4635 3185.63636363636 3049 6.08705757866974e-08 2012 1.88972728271382 -1.64355834019944 -1 13.5201646626308 4633 2873 2012 2068 2802 3811 3326 3763 2313 3049 4392 3335 M12049 GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of endothelial cell development. 13/14 Gene Ontology BP GO:1901550 1.71080391701943e-07 4.59245216956312e-07 3880 3019.90909090909 3050 1.55527640914371e-08 1648 2.47249826034367 1.99917721286518 1 18.849004351338 3879 3050 1873 3682 1648 4415 3754 2422 3654 1809 3033 3336 M14367 GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING.html The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. 27/28 Gene Ontology BP GO:0051084 8.64233604259708e-07 1.33375753254409e-06 2415 3243.36363636364 3050 7.85667221599791e-08 2041 1.08220558247972 1.23368540912027 1 7.58623883267822 2412 3993 3728 3822 2974 2963 2384 2041 4578 3732 3050 3337 M13833 GO_POSITIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEATH.html Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 721/961 Gene Ontology BP GO:0010942 6.06393492078989e-08 4.02645553947883e-07 4455 3045.54545454545 3051 6.06393508626077e-09 510 1.96574634977769 2.04930255641653 1 15.1004964623311 4454 2326 4452 1549 510 3051 4387 4295 2628 1308 4541 3338 M14578 GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. 13/14 Gene Ontology BP GO:1903140 1.71080391701943e-07 4.59245216956312e-07 3880 3020.90909090909 3051 1.55527640914371e-08 1649 2.47249826034367 1.99917721286518 1 18.849004351338 3880 3051 1874 3683 1649 4416 3755 2416 3655 1817 3034 3339 M10093 GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 114/171 Gene Ontology BP GO:0008277 7.35369805589288e-08 4.02645553947883e-07 3860 2628.72727272727 3052 6.68518027426986e-09 626 2.03969615394358 2.12482228036084 1 15.6724382418077 3858 2401 1439 2675 626 3052 3251 3110 3546 1294 3664 3340 M11307 GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 22/29 Gene Ontology BP GO:0071480 6.23876451465661e-06 7.5952305826e-06 3055 2948.72727272727 3052 5.67162018784369e-07 1055 1.29903263585508 1.35542874915862 1 7.93995100162354 3052 3283 3341 4128 3794 2512 1999 1055 4145 2960 2167 3341 M11312 GO_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 45/50 Gene Ontology BP GO:0010762 5.94566211366857e-07 1.00820575127186e-06 3335 3029 3053 5.40514883684381e-08 1952 1.49153393131546 1.3755850230572 1 10.7137830365285 3331 1952 3275 3053 2701 2021 2861 2478 3737 3288 4622 3342 M12409 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 34/44 Gene Ontology BP GO:0033144 1.92042281204179e-07 4.89360752707036e-07 3735 2726.09090909091 3054 1.74583907243569e-08 673 1.57434592374992 -1.7839573243063 -1 11.9120500145512 3734 673 2745 1196 1745 4295 3788 3054 3216 2203 3338 3343 M15153 GO_REGULATION_OF_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_MOVEMENT.html Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. 14/27 Gene Ontology BP GO:0003352 2.96190033356252e-05 3.3033850076861e-05 1675 2627.72727272727 3054 2.69267291901941e-06 711 1.51129202670772 -1.69136533910717 -1 8.08727600702133 1674 3054 3201 3560 4149 1641 711 945 4237 3722 2011 3344 M11767 GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 153/223 Gene Ontology BP GO:0043433 2.55819515239672e-07 5.65745344301423e-07 1130 2476.54545454545 3055 2.32563222715254e-08 835 1.76260362979785 -1.76700682101771 -1 13.2145059760476 1127 3144 3055 3494 2044 835 930 3966 3232 3539 1876 3345 M14642 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 72/84 Gene Ontology BP GO:0010803 9.63106351234117e-07 1.44980066395741e-06 785 2341.63636363636 3055 8.75551611689864e-08 502 1.65163860699891 -1.53793169020031 -1 11.5597549726219 782 3461 3163 3284 3055 521 502 3009 3881 3199 901 3346 M15918 GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. 9/13 Gene Ontology BP GO:0002320 4.4434830781394e-06 5.57141653532272e-06 3060 3031.45454545455 3056 4.44349196320824e-07 183 2.47512604623433 -2.9619733099939 -1 15.6245257542614 3056 3607 4581 2797 4349 4617 4035 183 377 3034 2710 3347 M10092 GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. 11/22 Gene Ontology BP GO:0050855 9.95530020757718e-06 1.17479106938515e-05 3265 2729 3057 9.05031386995863e-07 921 1.8529161793048 -1.75216007703105 -1 10.9448260892097 3263 3057 2455 2060 3916 3102 3321 3356 921 1853 2715 3348 M15582 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. 17/19 Gene Ontology BP GO:0097296 3.00474091758881e-07 6.24991483662974e-07 2095 2973.27272727273 3057 2.73158302543072e-08 988 1.61477885571412 -0.988552815636793 -1 12.0131370975577 2095 4282 3346 4536 2178 1718 988 3057 4059 3700 2747 3349 M12949 GO_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 137/175 Gene Ontology BP GO:0051591 7.13515850448538e-08 4.02645553947883e-07 590 2242.90909090909 3058 6.48650794172428e-09 9 2.17206351395227 -2.05676970432656 -1 16.6961924529502 3077 9 587 3684 589 3058 2494 3917 3178 685 3394 3350 M10418 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 57/100 Gene Ontology BP GO:0042509 4.58571542768839e-07 8.35774926950023e-07 3695 2804.81818181818 3059 4.1688330759478e-08 1224 2.2614149947696 2.01286959181064 1 16.5198196126833 3695 3201 1688 1224 2503 4064 3410 3059 2781 2014 3214 3351 M13829 GO_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENETIC_IMPRINTING.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 20/23 Gene Ontology BP GO:0071514 1.55056433221047e-07 4.40859340231257e-07 3040 3062.81818181818 3059 1.40960403772233e-08 482 2.11430705757209 1.87607371065834 1 16.1488042764725 3039 2635 2610 3922 1544 3231 4630 4623 3916 3059 482 3352 M14362 GO_GOLGI_RIBBON_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_RIBBON_FORMATION.html The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. 13/13 Gene Ontology BP GO:0090161 9.90453126702905e-06 1.16939314857869e-05 1165 2462.90909090909 3059 9.00415987100077e-07 276 0.813598794756979 -0.876947739541597 -1 4.74999255538326 1163 3059 3676 3968 3914 970 276 740 4277 4307 742 3353 M14917 GO_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEATH.html Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 1539/2183 Gene Ontology BP GO:0010941 8.60486637719231e-08 4.02645553947883e-07 4285 2953.72727272727 3059 8.60486671038909e-09 574 1.95652079897994 2.05663325582223 1 15.0291443066434 4283 1310 4525 2357 941 3059 4474 4261 2440 574 4267 3354 M12141 GO_REGULATION_OF_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of bone development. 13/31 Gene Ontology BP GO:1903010 4.58346143247518e-06 5.73610705898522e-06 4415 3245.90909090909 3060 4.16679180149809e-07 1883 2.31067576289504 1.49530672164798 1 14.544217994692 4412 3060 1883 2490 3694 3931 2927 3350 4342 2782 2834 3355 M16541 GO_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION.html The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. 217/248 Gene Ontology BP GO:0006260 9.28225212098018e-06 1.10039029602346e-05 45 2319.63636363636 3062 8.43844662267345e-07 43 1.30310639907579 1.34509151688565 1 7.71143270147552 43 3425 4085 3062 3897 275 202 1301 3742 3640 1844 3356 M12928 GO_PARENTAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARENTAL_BEHAVIOR.html A reproductive behavior in which a parent cares for and rears offspring. 10/16 Gene Ontology BP GO:0060746 1.82487377556889e-05 2.07759669139272e-05 2630 3169.27272727273 3063 1.65898992077738e-06 2125 2.93160662092399 2.67212135123125 1 16.4985223055986 2627 4317 2828 3512 4061 2125 2486 3063 3629 3633 2581 3357 M13478 GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY.html Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. 18/26 Gene Ontology BP GO:0001539 7.85425725915497e-08 4.02645553947883e-07 3065 2898.18181818182 3063 7.1402341268738e-09 703 2.20249233597266 2.36400959566914 1 16.9315347207225 3063 1057 2161 3389 703 3404 4382 4255 2976 2336 4154 3358 M12041 GO_BILE_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. 18/33 Gene Ontology BP GO:0006699 1.28367185711667e-06 1.8299403036654e-06 3385 2682.90909090909 3064 1.16697509647581e-07 1405 2.72296083775686 3.38667419549006 1 18.7916498521498 3385 2639 1405 2230 3229 3070 3064 1836 3134 2332 3188 3359 M12385 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE.html A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 14/15 Gene Ontology BP GO:0033540 1.23722425296871e-07 4.14338946095474e-07 3390 3037.36363636364 3064 1.1247493841337e-08 1276 1.54455169371182 -1.24021991671019 -1 11.8196730139748 3390 2218 3064 3708 1276 3675 4307 2646 2744 3360 3023 3360 M12372 GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 44/55 Gene Ontology BP GO:0006220 9.76773970003009e-07 1.46516095500451e-06 1105 2728.72727272727 3065 8.87976730617605e-08 1101 1.28896370105433 1.23968591917083 1 8.99166429059159 1101 2882 3637 3469 3065 1800 1698 2563 3074 3624 3103 3361 M12855 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. 14/14 Gene Ontology BP GO:0046929 3.68327688820127e-06 4.68348364067606e-06 2640 2805.27272727273 3065 3.34843914074513e-07 571 1.75471678777382 -1.73828523955154 -1 11.2068932174743 2637 3577 3186 2753 3632 3424 3065 2510 571 3716 1787 3362 M15521 GO_REGULATION_OF_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. 23/43 Gene Ontology BP GO:0098801 6.33984348530975e-08 4.02645553947883e-07 4235 2630 3065 5.76349424364366e-09 450 2.5666347287719 2.38683806470488 1 19.747880895937 4231 934 1220 3400 450 3738 1900 3065 3774 1661 4557 3363 M10081 GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION.html The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. 40/66 Gene Ontology BP GO:0060395 2.87019697250541e-07 6.04573404846884e-07 1760 2749.90909090909 3066 2.60927031541947e-08 568 2.17680098186551 2.56479153109796 1 16.2681071768003 3756 568 1156 1756 2148 3850 4152 3633 3066 1758 4406 3364 M12992 GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrate derivative. 532/665 Gene Ontology BP GO:1901137 5.1248544044249e-08 4.02645553947883e-07 3070 2960.72727272727 3066 5.12485452261349e-09 349 1.80076683711785 1.91520813512482 1 13.8245136911506 2648 2768 4399 4459 349 3066 3875 3069 2387 2350 3198 3365 M12451 GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. 12/12 Gene Ontology BP GO:0009396 5.25594594354855e-06 6.50423310514134e-06 1225 2578.54545454545 3067 4.77814409126735e-07 1223 1.24967278170458 1.2359968248261 1 7.73612315743746 1223 3067 3190 3887 3737 1417 1378 1430 3547 3080 2408 3366 M11658 GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. 24/35 Gene Ontology BP GO:0046471 1.19584662275631e-06 1.72215237873262e-06 1850 2623.36363636364 3068 1.08713388434467e-07 873 1.66100330229189 -1.57827339715593 -1 11.4756964285656 1850 3278 3068 3943 3191 1097 873 2371 3886 3741 1559 3367 M14380 GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 221/383 Gene Ontology BP GO:0071383 1.35148152001235e-07 4.23464209603869e-07 3385 3063.09090909091 3068 1.2286196391229e-08 1383 1.91759757587715 1.90494078200253 1 14.6773299969063 3384 3131 2240 4466 1383 2650 3635 3847 2891 2999 3068 3368 M14589 GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that activates or increases the frequency, rate or extent of protein acetylation. 41/48 Gene Ontology BP GO:1901985 2.26988267572036e-06 3.01076513401563e-06 3070 3221.36363636364 3068 2.06353183428082e-07 2432 1.73003928575276 1.62861454075791 1 11.4493336994299 3068 2889 2879 2795 3474 2632 2432 4048 3571 3197 4450 3369 M14946 GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 143/207 Gene Ontology BP GO:0051896 6.51127644481803e-08 4.02645553947883e-07 4185 2694.54545454545 3068 5.91934239775489e-09 486 2.10791937846601 -1.90847075309514 -1 16.2000895706396 4184 2391 1289 1200 486 4179 3068 3821 3472 1165 4385 3370 M16153 GO_GLYCEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROL_TRANSPORT.html The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. 5/11 Gene Ontology BP GO:0015793 2.3555640744942e-05 2.65193313298367e-05 3615 3031.72727272727 3070 2.3555890439362e-06 1038 3.93975411803879 -3.2707445934309 -1 21.7025224925859 3612 2751 4598 2657 4123 3619 3070 3335 1038 2621 1925 3371 M14439 GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 22/29 Gene Ontology BP GO:0006144 7.9087973676025e-07 1.24533448905091e-06 2250 2888.09090909091 3071 7.1898183734034e-08 943 1.19862904065539 0.920802570914675 1 8.45662645814138 2246 943 3453 3746 2909 2536 3345 2492 3459 3569 3071 3372 M10589 GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 96/133 Gene Ontology BP GO:0032481 1.22531552324583e-06 1.7591462911641e-06 1970 2772.54545454545 3072 1.11392382336369e-07 1145 1.79091825633341 -1.91520298745774 -1 12.3613255706003 1969 4147 3072 3305 3200 2494 1841 1145 3521 3557 2247 3373 M14156 GO_DRUG_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_METABOLIC_PROCESS.html The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. 28/89 Gene Ontology BP GO:0017144 5.36160095475462e-07 9.32130335465133e-07 2595 2815.36363636364 3073 4.87418387402381e-08 830 2.68100447942385 -2.90647988711306 -1 19.450409275707 2594 830 1033 3871 2628 3410 3073 4590 3924 1717 3299 3374 M11691 GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. 18/19 Gene Ontology BP GO:2000104 0.000232830405245675 0.000245104044255233 560 2556.36363636364 3074 2.11686408913829e-05 190 1.31637980226018 1.39205576555477 1 5.64529096259121 559 4529 3610 3074 4402 1079 190 2533 3353 3450 1341 3375 M10359 GO_NATURAL_KILLER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. 12/15 Gene Ontology BP GO:0001779 2.49775902638957e-07 5.59830093920551e-07 2470 2871.27272727273 3076 2.27069028179221e-08 1043 1.59302893243642 -1.27581864967948 -1 11.9420680366921 2470 3368 3053 4133 2015 2553 1043 3108 3148 3076 3617 3376 M12690 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. 70/84 Gene Ontology BP GO:0032873 9.2021016472762e-07 1.40292853750905e-06 3320 2946.09090909091 3078 8.36555045119012e-08 1721 1.56704502876156 -1.20710221508516 -1 10.9894639102569 3317 2455 3220 3078 3014 2799 1721 3296 2580 3735 3192 3377 M16264 GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that activates or increases the frequency, rate or extent of receptor recycling. 16/17 Gene Ontology BP GO:0001921 6.80610970434853e-06 8.21926510623766e-06 3220 2884.72727272727 3078 6.18739160037053e-07 999 1.35272104523426 -0.699022949647858 -1 8.21625967591418 3217 3027 3078 3784 3825 2114 999 2084 2269 3857 3478 3378 M11454 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 93/113 Gene Ontology BP GO:0008630 1.48719544971175e-06 2.07743032948326e-06 3780 2977.81818181818 3079 1.35199677732159e-07 1876 2.03949973023154 2.34656260620915 1 13.9132356700071 3777 3908 2584 1876 3299 3004 3957 3079 1958 3263 2051 3379 M13366 GO_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_GROWTH.html The increase in size or mass of an entire multicellular organism, as opposed to cell growth. 100/121 Gene Ontology BP GO:0035264 1.620933813498e-07 4.4734312183904e-07 3130 2884.90909090909 3079 1.47357630266044e-08 1542 1.55469302659614 -1.46216560339441 -1 11.8353716583845 3130 3176 3433 4171 1599 3079 3050 1542 1613 3914 3027 3380 M14839 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 70/84 Gene Ontology BP GO:0070303 9.2021016472762e-07 1.40292853750905e-06 3320 2928.63636363636 3079 8.36555045119012e-08 1722 1.56704502876156 -1.20710221508516 -1 10.9894639102569 3318 2456 3221 3079 3015 2800 1722 3094 2581 3736 3193 3381 M16159 GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. 53/67 Gene Ontology BP GO:0035306 5.17555352754092e-08 4.02645553947883e-07 2500 2590.09090909091 3080 4.70504877208827e-09 266 1.51245129871563 1.80650068297274 1 11.594626757108 2499 477 3080 3780 266 2508 3468 3653 3657 3904 1199 3382 M10053 GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. 15/25 Gene Ontology BP GO:1900225 2.83543943686125e-06 3.68322158004338e-06 1235 2772.27272727273 3081 2.57767553753143e-07 1231 1.64507687679162 -1.79709910563425 -1 10.7078122948963 1231 4070 3081 3330 3554 1901 1818 1878 4105 4022 1505 3383 M12063 GO_PEPTIDYL_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_AMINO_ACID_MODIFICATION.html The alteration of an amino acid residue in a peptide. 830/1025 Gene Ontology BP GO:0018193 3.38474558981093e-07 6.79724696995696e-07 4345 3259.18181818182 3081 3.38474610535366e-08 2296 1.69712330857373 1.78703006177699 1 12.5561565264878 2794 3873 4341 3837 2352 2842 3220 2296 2873 4342 3081 3384 M11451 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. 11/12 Gene Ontology BP GO:0070202 0.0010969841561031 0.00112951256436108 1270 2895.18181818182 3082 9.97755933218519e-05 275 0.702865975102087 0.653987085103859 1 2.40221518068002 1269 3082 3827 2614 4499 1511 275 3150 4060 4608 2952 3385 M13607 GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. 20/22 Gene Ontology BP GO:0034315 1.90687965480233e-06 2.58528876276085e-06 1285 2742 3082 1.73352846147089e-07 1282 1.35045366045323 -1.51401482625625 -1 9.02272834569977 1282 2634 3446 3082 3401 1663 1398 4300 3174 3886 1896 3386 M11136 GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of smooth muscle contraction. 54/84 Gene Ontology BP GO:0006940 8.27677874165166e-07 1.29000766299311e-06 4110 2845.45454545455 3084 7.52434714138177e-08 764 2.77888533890881 2.90586497811314 1 19.6900254823982 3522 3473 764 4108 2940 4108 3354 2044 3084 829 3074 3387 M11864 GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE.html The movement of organelles or other particles from one location in the cell to another along microtubules. 117/133 Gene Ontology BP GO:0010970 1.00458203521423e-06 1.49556449550113e-06 2075 2908.45454545455 3084 9.13256812668192e-08 1104 1.32506105742847 1.56814868808092 1 9.23206445253074 2073 4367 3966 4374 3084 1104 1797 2105 3733 4201 1189 3388 M16916 GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. 18/21 Gene Ontology BP GO:0046112 4.65687892994587e-07 8.43787292096501e-07 1835 3208.18181818182 3084 4.23352719608831e-08 1834 0.779596126103535 0.695147611778933 1 5.62364170349282 1834 2191 3843 4189 2517 2639 3084 3078 4262 4297 3356 3389 M10258 GO_EMBRYONIC_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEMOPOIESIS.html The stages of blood cell formation that take place within the embryo. 21/26 Gene Ontology BP GO:0035162 0.000280660164262288 0.00029419052586448 2010 3101 3085 2.55178159329011e-05 2009 1.5856698967707 1.33523910312299 1 6.66917048646489 2009 4014 3085 2608 4417 2666 2310 3785 3270 2829 3118 3390 M13195 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. 191/225 Gene Ontology BP GO:2001236 1.07876217945435e-07 4.02645553947883e-07 3225 2819.63636363636 3086 9.80692938500978e-09 1111 1.94566850608983 2.13482069066577 1 14.9452106197732 3222 3135 1591 2338 1111 2995 4492 4135 3427 1484 3086 3391 M14289 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleoside across a membrane. 10/13 Gene Ontology BP GO:1901642 1.05375225950065e-07 4.02645553947883e-07 3345 2776.54545454545 3086 9.5795664543009e-09 538 2.03730539182477 -2.54754561639697 -1 15.6539476351596 3341 3086 2794 3914 1081 3174 2879 538 2564 3635 3536 3392 M15528 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. 26/55 Gene Ontology BP GO:0046638 1.96235003474648e-07 4.93246485651519e-07 2365 3101.81818181818 3086 1.78395473616698e-08 1772 1.87182545328319 -1.94815594200053 -1 14.1745623708162 2362 3525 3086 3965 1772 3166 3995 2917 3927 2801 2604 3393 M16318 GO_MITOTIC_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. 12/13 Gene Ontology BP GO:0007064 1.93361441673137e-07 4.91108508790997e-07 3895 3148.36363636364 3087 1.75783144243617e-08 1457 1.60942603010724 1.54385782651757 1 12.1767587559415 3893 3061 2964 3426 1751 4112 4288 2111 1457 3087 4482 3394 M15673 GO_AXONEME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_ASSEMBLY.html The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 53/98 Gene Ontology BP GO:0035082 2.76198872094364e-07 5.9006122674705e-07 3530 3210.18181818182 3088 2.5108991524522e-08 2120 2.32227683431083 2.0073135354629 1 17.3918230422684 3530 4423 2293 4163 2120 3088 3488 2353 2670 2845 4339 3395 M15849 GO_DORSAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. 7/28 Gene Ontology BP GO:0021516 2.27175015297686e-06 3.01238343169032e-06 3520 2548.45454545455 3089 2.27175247536214e-07 120 2.63678131931117 1.89044720638714 1 17.5033354027924 3089 1262 4576 1065 3510 3517 3915 1548 120 1914 3517 3396 M14359 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. 45/59 Gene Ontology BP GO:0060760 5.27421866810267e-06 6.52337572107435e-06 3095 3139.63636363636 3091 4.79475573855446e-07 2055 2.01720349989533 -2.27140433376671 -1 12.5476582087822 3091 3493 2599 2134 3739 2904 3278 4489 3756 2055 2998 3397 M15427 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 23/30 Gene Ontology BP GO:0071354 1.25744673527427e-05 1.46309068747967e-05 1230 2788.54545454545 3091 1.14313992952597e-06 1227 1.2373078684879 -1.20086782162871 -1 7.13171506629119 1227 3276 3483 3091 3971 1749 1335 1809 4377 3398 2958 3398 M16546 GO_RESPONSE_TO_MANGANESE_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MANGANESE_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. 25/30 Gene Ontology BP GO:0010042 0.000404810380691993 0.000421949529874516 1685 2845.81818181818 3092 3.68077169914669e-05 563 2.25440194307085 -2.20740601932304 -1 9.0981604835247 1684 4486 2951 3092 4442 1407 563 3434 3632 3801 1812 3399 M13644 GO_OUTER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 34/61 Gene Ontology BP GO:0036158 1.97646628237417e-07 4.93246485651519e-07 3800 3063.45454545455 3093 1.79678769085335e-08 1062 2.70879521480794 2.4300210464774 1 20.5586259227747 3799 4205 1913 4140 1784 4486 4209 1062 2078 3093 2929 3400 M13854 GO_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_RECOMBINATION.html Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. 191/230 Gene Ontology BP GO:0006310 7.47956241264221e-06 8.98590340976612e-06 145 2378.72727272727 3093 6.79962531071612e-07 143 1.22135564491484 1.34791534023167 1 7.35115769719198 143 3427 4107 3093 3848 363 229 1580 3640 4132 1604 3401 M15100 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 34/49 Gene Ontology BP GO:0032228 2.19755940286648e-06 2.92903004913714e-06 3095 2920.18181818182 3093 1.99778327090097e-07 2150 2.1177095456506 -1.88824238715624 -1 14.0686051735742 2482 2547 2150 3669 3459 3093 2250 3400 2393 3094 3585 3402 M11779 GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 31/63 Gene Ontology BP GO:0045979 7.66862287700977e-06 9.19404850469633e-06 4400 3195.36363636364 3096 6.97149964358897e-07 1673 1.63085331406648 1.55687130269483 1 9.83076788636385 4398 2564 3096 1673 3855 4223 2936 2954 2928 3301 3221 3403 M14058 GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of ATP metabolic process. 31/63 Gene Ontology BP GO:1903580 7.66862287700977e-06 9.19404850469633e-06 4400 3181.63636363636 3097 6.97149964358897e-07 1674 1.63085331406648 1.55687130269483 1 9.83076788636385 4399 2565 3097 1674 3856 4224 2937 2791 2929 3304 3222 3404 M14667 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 7/14 Gene Ontology BP GO:0032740 1.19034523927203e-06 1.71529154485374e-06 3100 3043.36363636364 3097 1.19034587688731e-07 1926 2.07612043008047 -1.63010337213537 -1 14.3737808846052 3097 3102 4509 3271 3240 2935 2423 2792 1926 2530 3652 3405 M11696 GO_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that modulates the frequency, rate, or extent of leukocyte migration. 130/208 Gene Ontology BP GO:0002685 2.67371314625912e-09 5.01644647965472e-08 3690 2300.27272727273 3098 2.43064831773505e-10 5 2.63634025878123 -2.72022035066905 -1 23.1709741993732 3686 5 176 1710 383 4056 3098 4639 3121 398 4031 3406 M10079 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. 46/56 Gene Ontology BP GO:1903573 1.57651790458103e-05 1.81124390370754e-05 335 2391.81818181818 3099 1.4332083654606e-06 109 1.5195492555124 -1.445479258769 -1 8.61164212019152 331 4438 3622 3099 4023 305 109 1906 4069 4011 397 3407 M14207 GO_GOLGI_TO_VACUOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_VACUOLE_TRANSPORT.html The directed movement of substances from the Golgi to the vacuole. 37/38 Gene Ontology BP GO:0006896 1.02027643757211e-06 1.51111922298151e-06 615 2277.54545454545 3100 9.27524464307163e-08 124 0.986450769776404 -0.991369060452547 -1 6.8412024882287 614 3956 3923 3963 3100 377 124 1066 3402 4243 285 3408 M15455 GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. 58/69 Gene Ontology BP GO:0034637 9.58265819868698e-08 4.02645553947883e-07 3835 2883.27272727273 3100 8.71150783280366e-09 953 1.83986070915559 2.14055167521428 1 14.1268730955073 3835 2478 2608 3692 953 3100 3372 3275 2361 3206 2836 3409 M16142 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. 65/115 Gene Ontology BP GO:0002690 3.39019524146444e-08 3.99952679980378e-07 4475 2729.18181818182 3100 3.08199572155207e-09 85 2.63136863843606 -2.52154442289826 -1 20.2578195744334 4473 1883 459 2381 85 4496 3458 4445 3100 724 4517 3410 M16186 GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycosyl compound. 34/46 Gene Ontology BP GO:1901658 4.32624025789088e-06 5.4390694190668e-06 2665 2888.81818181818 3100 3.93295342304389e-07 1289 2.03349146552297 2.58282367796785 1 12.8439621962478 2662 3501 2600 3420 3677 3475 3353 1892 1289 2808 3100 3411 M14393 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 53/56 Gene Ontology BP GO:0032206 5.10496908507874e-05 5.59035564906363e-05 1675 2873.90909090909 3102 4.6409886788154e-06 1018 1.43643001327759 1.25646917169724 1 7.28465266708806 1671 4181 3846 3638 4222 1501 1167 3102 1018 4447 2820 3412 M10999 GO_PEROXISOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 35/36 Gene Ontology BP GO:0007031 6.95058461747244e-06 8.38503246696895e-06 615 2283 3103 6.31873325176842e-07 140 1.27497647252644 -0.965768175429324 -1 7.72476008035063 613 3961 3831 3804 4318 340 140 216 3103 4278 509 3413 M14621 GO_DNA_GEOMETRIC_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_GEOMETRIC_CHANGE.html The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. 91/101 Gene Ontology BP GO:0032392 5.60184382370536e-06 6.89860607571572e-06 565 2503.81818181818 3103 5.09259826153631e-07 565 1.28989954260597 1.48036323478871 1 7.94858006553359 565 3670 4027 3103 3752 617 583 1966 3819 3831 1609 3414 M10278 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 44/52 Gene Ontology BP GO:0042771 0.00040661654290849 0.00042364235874456 3105 3381.72727272727 3104 3.69719741407538e-05 2398 2.15998307281469 -1.85209545539327 -1 8.70825680294555 2646 4197 3103 3104 4444 2458 2735 4521 3448 4145 2398 3415 M11356 GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 16/23 Gene Ontology BP GO:0060390 7.90684318292494e-06 9.46015462333499e-06 1915 2540.72727272727 3104 7.18806509128866e-07 383 1.54962106403398 1.68110727013911 1 9.31274948183707 1911 3564 3193 2583 3864 1110 383 3528 3104 3579 1129 3416 M12724 GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of natural killer cell activation. 22/34 Gene Ontology BP GO:0032814 1.02426860359513e-06 1.51547384793489e-06 3800 3214.36363636364 3104 9.31153709519068e-08 2067 2.36442000777551 -1.45509907298021 -1 16.5378993538307 3796 3758 2067 2965 3104 3643 3881 2506 2952 2217 4469 3417 M11061 GO_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease. 10/54 Gene Ontology BP GO:0042737 8.50755776600356e-07 1.31688843264187e-06 2460 3044.54545454545 3105 7.73414641448996e-08 1143 3.21111198973828 -3.83821462631628 -1 22.7338343257949 2460 3089 1143 4315 2965 3298 3839 3483 4180 1613 3105 3418 M11346 GO_APOPTOTIC_CELL_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_CELL_CLEARANCE.html The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. 38/46 Gene Ontology BP GO:0043277 1.30957041398997e-07 4.19080545824987e-07 3950 2808.36363636364 3105 1.19051862903942e-08 1352 1.96126825583175 2.26658041926067 1 15.0246503251449 3949 1974 2252 1862 1352 3659 4488 3105 3482 1508 3261 3419 M13573 GO_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 151/182 Gene Ontology BP GO:0009411 6.23089336538158e-06 7.58763329733591e-06 3815 3183.09090909091 3108 5.66446455703535e-07 1961 1.5576849328991 1.63567111221936 1 9.5422051728755 2556 4126 3815 3108 3793 1961 2667 2265 3815 4266 2642 3420 M15232 GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. 1133/1532 Gene Ontology BP GO:0051248 9.74483972810087e-08 4.02645553947883e-07 3705 3130.45454545455 3108 9.74484015542945e-09 1104 1.87521697214528 2.02426904366976 1 14.4003251241915 3703 3108 4543 2289 1104 2892 4279 2702 2906 3384 3525 3421 M13155 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. 50/55 Gene Ontology BP GO:0034502 6.4256194108998e-06 7.80026274952173e-06 590 2208.09090909091 3110 5.84148925319554e-07 228 1.71059616365673 1.64438582807715 1 10.4641978596551 586 3486 3110 3911 3807 432 228 736 3641 3430 922 3422 M13662 GO_NEGATIVE_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANOIKIS.html Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. 32/35 Gene Ontology BP GO:2000811 7.95801405440122e-07 1.25266033136431e-06 3160 2729.72727272727 3110 7.2345608482168e-08 803 2.61374305547939 -2.39091407908242 -1 18.5541092123358 3158 3234 1754 1852 2911 4133 3110 3807 803 1961 3304 3423 M14006 GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. 6/15 Gene Ontology BP GO:0033004 1.55884621478989e-06 2.16387572715315e-06 3460 3155.36363636364 3111 1.55884730829165e-07 1282 1.22268674109297 1.08453981139679 1 8.27361401991638 3457 1282 4464 2553 3352 3003 3111 4225 3497 2937 2828 3424 M15208 GO__DE_NOVO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_PROTEIN_FOLDING.html The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. 32/33 Gene Ontology BP GO:0006458 1.03748031019868e-06 1.53299329417417e-06 1385 2787.45454545455 3112 9.43164363141816e-08 1078 1.04740743854732 1.14069382446238 1 7.26240309778198 1383 3976 3796 3821 3112 1852 1149 1078 4560 3646 2289 3425 M10187 GO_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. 98/182 Gene Ontology BP GO:0006694 1.04104193296775e-06 1.53776765526951e-06 2395 3035.72727272727 3113 9.4640220508185e-08 2391 1.92984138329303 -1.75463778263798 -1 13.4645197644116 2391 3173 2636 3722 3113 2941 2836 2417 3281 3403 3480 3426 M15219 GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. 16/22 Gene Ontology BP GO:0010310 3.54115230833972e-05 3.92589508951745e-05 1505 2692.54545454545 3114 3.21928118957436e-06 435 1.55238255092036 -1.86122769120009 -1 8.16919024715664 1501 4058 3114 3787 4468 1871 1480 435 4025 4236 643 3427 M10230 GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that activates or increases the frequency, rate or extent of reproductive process. 51/84 Gene Ontology BP GO:2000243 1.16146322750364e-07 4.08548528935279e-07 4345 2302.90909090909 3115 1.05587571711062e-08 453 2.50697059977094 2.71557843852036 1 19.2672632214081 4345 453 662 593 1207 3463 3946 3625 3267 656 3115 3428 M14936 GO_POSITIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 431/537 Gene Ontology BP GO:0045862 1.0384518650871e-07 4.02645553947883e-07 3820 3119.27272727273 3117 9.44047194640433e-09 1060 1.86340861509778 1.98772962821 1 14.3089970562051 3816 3117 2614 2597 1060 3061 3959 4010 2523 3769 3786 3429 M12742 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. 72/101 Gene Ontology BP GO:0032088 1.05620827637075e-06 1.55579166818521e-06 545 2219.54545454545 3121 9.60189803137325e-08 369 1.59298867056585 -1.56001390551088 -1 11.0865745334062 544 1878 3177 3578 3121 369 527 3257 3692 3690 582 3430 M14831 GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of chromosome organization. 165/184 Gene Ontology BP GO:2001252 2.15376392238064e-06 2.87868235500217e-06 2455 3160 3121 1.95796911898463e-07 2399 1.73792501404272 1.76818317822218 1 11.5429409048242 2453 4125 3762 3121 3450 2566 2660 2685 2399 4378 3161 3431 M15102 GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 13/15 Gene Ontology BP GO:0009143 1.2533216651237e-07 4.14772809944564e-07 3975 2785.45454545455 3121 1.13938339684036e-08 735 1.99877834264006 1.70314180564955 1 15.3248192823914 3973 2230 2016 3373 1296 3773 3121 3244 3042 735 3837 3432 M13975 GO_MUSCLE_ATROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ATROPHY.html A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. 11/18 Gene Ontology BP GO:0014889 2.76120045884855e-05 3.08694515497892e-05 3240 2978 3122 2.51021374094473e-06 1758 2.10419244838618 -1.77783633562682 -1 11.3753104652415 2204 3842 2571 3240 4138 3122 2406 1758 3239 3749 2489 3433 M13578 GO_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_GENOME_REPLICATION.html Any process involved directly in viral genome replication, including viral nucleotide metabolism. 21/31 Gene Ontology BP GO:0019079 5.75342524970735e-08 4.02645553947883e-07 2835 2984.54545454545 3123 5.23038672742777e-09 367 0.884674699506196 0.861304540454032 1 6.73928374010476 2834 3544 3920 4002 367 2744 3123 2131 4047 4255 1863 3434 M11797 GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 37/46 Gene Ontology BP GO:0043516 3.54473655609679e-06 4.51881073849818e-06 1305 2676.09090909091 3124 3.22249297049526e-07 666 1.79753598763873 2.29383359692682 1 11.5166735835823 1303 4201 3124 4222 3623 1546 1185 666 4006 3766 1795 3435 M11863 GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. 44/49 Gene Ontology BP GO:0051058 1.28669631971541e-06 1.83369003847957e-06 2600 3176.90909090909 3124 1.1697246111416e-07 2168 1.99127259696396 2.1256707992298 1 13.7123289459823 2597 4436 2792 3726 3230 3124 4340 2763 2349 3421 2168 3436 M13136 GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus. 26/29 Gene Ontology BP GO:2001273 2.22171076627862e-07 5.17979430590306e-07 4535 3162.18181818182 3124 2.01973726422021e-08 1926 1.82650433088383 -1.90590297321672 -1 13.7819340371361 4534 2593 2576 3050 1926 3757 3686 3438 3303 2797 3124 3437 M10889 GO_COFACTOR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORT.html The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. 25/27 Gene Ontology BP GO:0051181 4.43096438240288e-07 8.17030012087984e-07 3490 2736.27272727273 3125 4.02815024984769e-08 224 2.13701476847523 -1.66827929907592 -1 15.6308629479208 3488 909 2302 3863 2472 3838 3125 3175 224 2991 3712 3438 M11284 GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. 11/16 Gene Ontology BP GO:0043922 6.51320966129286e-05 7.05774675221138e-05 2020 3009.45454545455 3125 5.92127499645824e-06 738 1.35918524018438 -1.49900608155709 -1 6.72098422658297 2018 3856 3125 4220 4264 1919 738 3334 4421 2899 2310 3439 M11644 GO_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 286/425 Gene Ontology BP GO:0002521 1.23189479134529e-07 4.14338946095474e-07 3750 2469 3125 1.11990441847774e-08 466 2.1684359943511 -2.01532353618679 -1 16.6355313740369 3748 1576 544 1541 1265 3953 3185 3500 3125 466 4256 3440 M15133 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of natural killer cell activation. 16/23 Gene Ontology BP GO:0032816 1.04674785878576e-05 1.23055022408543e-05 2210 2909.81818181818 3125 9.51593490170437e-07 947 1.68523427187028 -1.28134847260543 -1 9.90399836536785 2207 3347 2881 3743 3931 1796 947 3125 3760 2868 3403 3441 M11689 GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. 239/337 Gene Ontology BP GO:0016053 1.01594117040164e-07 4.02645553947883e-07 4125 2660.36363636364 3126 9.23582924833577e-09 438 2.03766287518429 2.0138892924151 1 15.6567124791113 4123 1606 577 3126 1030 3893 4255 3213 2741 438 4262 3442 M13249 GO_DNA_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEMETHYLATION.html The removal of a methyl group from one or more nucleotides within an DNA molecule. 11/14 Gene Ontology BP GO:0080111 1.14861813958514e-05 1.3418328404443e-05 3130 3184.54545454545 3127 1.04420376050415e-06 2018 1.47217385338483 1.97008556323223 1 8.57189815646076 3127 3383 3061 4483 3961 3147 2534 2018 3108 4029 2179 3443 M16511 GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. 782/916 Gene Ontology BP GO:0006974 9.70170651945599e-07 1.45666474459596e-06 1495 2920.63636363636 3127 9.70171075499851e-08 547 1.39335329622466 1.49515170478039 1 9.73246865768153 1492 4111 4627 4088 3127 547 1084 2849 3548 4522 2132 3444 M10592 GO_MYELOID_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. 51/60 Gene Ontology BP GO:0061515 1.06822069884824e-06 1.56994027534455e-06 2700 3051.27272727273 3130 9.7111019775304e-08 2325 1.41447663760827 -1.27947036246194 -1 9.82593763962928 2698 3481 3385 3760 3130 2608 2325 2846 3577 3299 2455 3445 M14368 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex assembly. 219/268 Gene Ontology BP GO:0031334 9.65785205253862e-08 4.02645553947883e-07 3650 3063.36363636364 3130 8.77986588773804e-09 962 1.85213580966747 -1.88252384336845 -1 14.2218110457725 3648 3130 2830 2308 962 4458 3564 4272 1907 3876 2742 3446 M14919 GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. 22/23 Gene Ontology BP GO:0051497 3.29216492199552e-07 6.66639210726007e-07 4140 3071 3130 2.9928776496799e-08 1807 1.46009536053712 1.20001412335563 1 10.8030346612528 4137 2119 2734 4111 2242 3630 3130 1807 3605 3269 2997 3447 M15516 GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION.html Any process that modulates the frequency, rate or extent of interferon-gamma secretion. 8/15 Gene Ontology BP GO:1902713 6.29490441691691e-08 4.02645553947883e-07 3360 2868.27272727273 3130 6.2949045952331e-09 557 1.98600641912281 1.71017802174413 1 15.2571916726061 3360 2742 4562 2307 557 3130 3184 3758 1795 1589 4567 3448 M12251 GO_POLYAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. 15/17 Gene Ontology BP GO:0006595 8.02780146502804e-06 9.5974717925939e-06 1485 2399.09090909091 3131 7.29802796239143e-07 351 1.32833169614206 1.2288042792415 1 7.95811100130496 1482 3352 3390 3732 3866 754 351 1673 4010 3131 649 3449 M13259 GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. 122/178 Gene Ontology BP GO:0032845 1.71581073125532e-06 2.35923975547607e-06 3135 3076.45454545455 3131 1.55982915403777e-07 2070 1.82871236755254 2.02253280102162 1 12.3424438683303 3131 2823 2395 2070 3353 3033 3487 3965 3668 2400 3516 3450 M13558 GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 1384/2007 Gene Ontology BP GO:1901700 6.16316082403392e-14 2.47217132019223e-12 4135 2580.27272727273 3131 6.16316082403408e-15 19 2.16528002998282 2.28442544373267 1 30.2919006452796 4133 1319 4435 19 498 4207 3131 3962 2385 72 4222 3451 M12120 GO_RESPONSE_TO_XENOBIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_XENOBIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. 74/205 Gene Ontology BP GO:0009410 2.70420442918144e-07 5.81453937568449e-07 3555 2822.81818181818 3133 2.45836796507084e-08 718 2.57628602004955 -2.74745509854101 -1 19.3252752110186 3553 2447 718 3133 2104 3947 3169 4013 2762 1090 4115 3452 M15127 GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that activates or increases the frequency, rate or extent of DNA recombination. 16/22 Gene Ontology BP GO:0045911 2.81065907748909e-06 3.65307170043484e-06 3995 3071.18181818182 3135 2.55514788028701e-07 1206 1.57877277344202 -1.61845100427092 -1 10.2789046988807 3995 4041 3135 2735 3552 3421 1206 4132 1822 2867 2877 3453 M15710 GO_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLATION.html The covalent attachment and further modification of carbohydrate residues to a substrate molecule. 226/292 Gene Ontology BP GO:0070085 4.42214412786454e-08 4.02645553947883e-07 4085 2961.81818181818 3135 4.02013110613867e-09 173 1.84274860987725 -1.75535784194491 -1 14.149208666187 4082 2785 2386 3135 173 3842 3266 3281 2129 2878 4623 3454 M10235 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that activates or increases the rate of gene expression. 77/111 Gene Ontology BP GO:0045815 5.84741421358687e-06 7.16943829665868e-06 2590 3087.36363636364 3137 5.31584523234352e-07 1340 1.93386932765458 2.32082544050388 1 11.9291180726175 2590 4158 3320 4204 3766 2813 3137 1340 2617 4130 1886 3455 M13287 GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. 14/15 Gene Ontology BP GO:0032354 1.07805539532601e-06 1.58089875652441e-06 3715 2998.81818181818 3138 9.80050839636967e-08 1968 1.97025625268735 1.55351922095778 1 13.7200251522373 3714 2239 2456 3210 3138 3734 1968 2079 3606 2488 4355 3456 M14429 GO_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. 132/179 Gene Ontology BP GO:0006006 1.99257784411474e-06 2.69050049584036e-06 3485 2960.72727272727 3138 1.81143604439005e-07 1199 1.76121183777398 -1.87102630815023 -1 11.7615251273339 3013 3153 3138 3481 3414 3484 3397 1199 3000 2986 2303 3457 M15278 GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. 187/372 Gene Ontology BP GO:0071824 1.16341174790529e-06 1.68325710914282e-06 335 2176.72727272727 3138 1.05764760285931e-07 208 1.44787533588802 1.4805748326419 1 10.0073794505628 333 3138 3898 3526 3179 208 523 898 3846 3412 983 3458 M14375 GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 23/26 Gene Ontology BP GO:2001269 1.49814645710351e-07 4.36901586057683e-07 3385 3238.36363636364 3139 1.36195141738513e-08 1498 1.85336085796384 -1.54921654021429 -1 14.1518023959298 3382 4243 3139 4387 1498 2954 3103 2407 4120 3397 2992 3459 M16107 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 984/1448 Gene Ontology BP GO:0051241 4.07011742918101e-17 2.78503770558518e-15 3605 2524.90909090909 3139 4.07011742918103e-18 40 2.21743868268637 2.44636770487381 1 38.9305767609238 3602 1345 4593 359 849 3139 4598 3198 2367 40 3684 3460 M11285 GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. 23/27 Gene Ontology BP GO:0007176 8.62969179062637e-07 1.33224803920984e-06 2975 3210.18181818182 3140 7.84517743245461e-08 1717 1.32373076494779 -0.889521738759806 -1 9.30309069100511 2651 2973 3196 3757 2973 2911 1717 4636 3693 3665 3140 3461 M10362 GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. 180/198 Gene Ontology BP GO:0032434 1.09045006662281e-07 4.02645553947883e-07 3500 3156.54545454545 3141 9.91318291519966e-09 1132 1.57038015920917 1.73556583885481 1 12.0426595264634 3498 3141 3789 2145 1132 2784 2844 4652 2208 4186 4343 3462 M13802 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. 107/128 Gene Ontology BP GO:2001251 2.19241274859271e-06 2.92384537667007e-06 560 2511.72727272727 3142 1.9931044849522e-07 556 1.38133771005483 1.54612605876426 1 9.14214215806574 556 4140 4042 3631 3458 1408 1015 889 3142 4288 1060 3463 M16729 GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 20/23 Gene Ontology BP GO:0048569 0.000134433230888054 0.000142942829826808 2150 3179.90909090909 3143 1.22219496608881e-05 1550 2.5570459995607 3.11949575474976 1 11.7871434796876 2149 4518 2556 4499 4351 2456 3989 2088 3143 3680 1550 3464 M15353 GO_SPERMATID_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_DIFFERENTIATION.html The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 113/283 Gene Ontology BP GO:0048515 2.27884604595887e-07 5.28061287442561e-07 2970 3262.09090909091 3144 2.07167843819154e-08 1943 1.38617282552787 1.43401956914765 1 10.4205459283888 2970 3662 3826 4025 1943 3144 2591 4246 3943 3000 2533 3465 M16793 GO_PROGESTERONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROGESTERONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. 14/26 Gene Ontology BP GO:0042448 3.13635130547543e-05 3.49627278974058e-05 1910 3203.18181818182 3145 2.85126910785305e-06 1840 1.49088548248222 -1.78821278972583 -1 7.93224687483645 1908 3063 3145 4364 4150 2733 1840 3940 4358 3367 2367 3466 M10981 GO_SUCKLING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUCKLING_BEHAVIOR.html Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. 12/21 Gene Ontology BP GO:0001967 9.1185167313471e-05 9.80324823266129e-05 3080 3156.09090909091 3146 8.28990426887954e-06 1308 1.4878223586728 2.08181322085623 1 7.11004437449758 3146 3076 3180 3034 4303 3078 3743 1308 3783 4087 1979 3467 M11096 GO_ALDEHYDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. 16/18 Gene Ontology BP GO:0046185 2.26635889857662e-06 3.00780603396378e-06 1865 2790.90909090909 3146 2.06032839390853e-07 1712 2.44158044613909 -2.62223750217813 -1 16.2018919640073 1862 3326 2109 2454 3473 3162 3634 3411 1712 2411 3146 3468 M12839 GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. 22/25 Gene Ontology BP GO:0060716 5.44202354253184e-06 6.71307941235436e-06 2020 3138.54545454545 3146 4.94730636747639e-07 2017 1.63429468455046 -2.15434206975219 -1 10.1216915471799 2017 3766 3146 4006 3747 2631 2551 2287 3785 3814 2774 3469 M16039 GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 27/31 Gene Ontology BP GO:1902176 3.13851714495716e-07 6.44178221238891e-07 2885 2969.09090909091 3146 2.85319781154337e-08 2147 1.18777344458962 1.26260016656704 1 8.79034340730801 2884 3264 3557 2147 2207 2520 3146 3167 2883 3485 3400 3470 M16419 GO_RRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. 19/20 Gene Ontology BP GO:0031167 1.08650838608736e-06 1.58978727058631e-06 1295 2517.18181818182 3146 9.87735384253503e-08 121 0.887454010428625 0.780653009498135 1 6.12065528041547 1291 3318 3830 4358 3146 379 121 1691 4337 4047 1171 3471 M11709 GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glutathione derivative. 18/28 Gene Ontology BP GO:1901687 1.50897255500539e-05 1.73750291968327e-05 2555 3124.54545454545 3147 1.37180264099679e-06 2127 1.76288302184294 1.60226836837662 1 10.0456448997247 2554 2998 3232 2740 4014 2127 2980 3635 3195 3147 3748 3472 M11748 GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. 18/22 Gene Ontology BP GO:0006206 6.06455760722919e-07 1.02182520155145e-06 3025 2739.72727272727 3147 5.51323570817832e-08 716 1.45977778961664 1.87778854412056 1 10.4731965247063 3025 3314 3147 3472 2719 3847 3701 716 1631 3451 1114 3473 M12168 GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. 18/24 Gene Ontology BP GO:0051446 2.67500501363138e-05 2.99561933295471e-05 2685 3198.81818181818 3149 2.43185230897743e-06 2502 1.88280332068249 -1.90572135233838 -1 10.1973414964537 2684 3012 2858 3563 4131 3176 3760 2502 3554 3149 2798 3474 M12449 GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione derivative. 18/28 Gene Ontology BP GO:1901685 1.50897255500539e-05 1.73750291968327e-05 2555 3124.54545454545 3150 1.37180264099679e-06 2128 1.76288302184294 1.60226836837662 1 10.0456448997247 2555 2999 3233 2741 4015 2128 2981 3623 3196 3150 3749 3475 M13926 GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. 139/188 Gene Ontology BP GO:0050852 3.94653827296567e-07 7.51360171199233e-07 2945 3162.27272727273 3151 3.58776270993442e-08 2151 1.36299350356803 -1.42256254294442 -1 9.99209848952678 2943 3151 3973 2151 2394 4077 3351 2551 3584 4194 2416 3476 M12648 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation. 18/54 Gene Ontology BP GO:0002577 3.18338703682002e-08 3.85278716745714e-07 4315 2727.72727272727 3152 2.89398825716676e-09 78 2.10909688353695 -2.07818715107366 -1 16.2580378311527 4311 2164 1577 3152 78 3765 4110 4091 3244 1228 2285 3477 M14264 GO_PROTEIN_DEGLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEGLYCOSYLATION.html The removal of sugar residues from a glycosylated protein. 21/22 Gene Ontology BP GO:0006517 1.09080396856158e-06 1.59306681284276e-06 2205 2736.36363636364 3152 9.9164046309488e-08 612 1.12231738797009 -0.956623716813124 -1 7.76651040614669 2203 938 3547 3191 3152 2501 2084 4547 612 3949 3376 3478 M11851 GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). 94/127 Gene Ontology BP GO:0043648 1.97684968870288e-07 4.93246485651519e-07 3550 2944.81818181818 3153 1.79713624212391e-08 157 1.9794394354646 -2.33525417892107 -1 14.9953978811385 3546 157 2249 3153 1785 4604 4561 4299 2235 2472 3332 3479 M13550 GO_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. 583/846 Gene Ontology BP GO:0006325 9.94070022332143e-07 1.48488212324606e-06 1905 3114.18181818182 3153 9.94070467011266e-08 1639 1.30776552775227 1.41885902111254 1 9.11514168690565 1902 4113 4434 4449 3153 1639 2119 2298 3581 4536 2032 3480 M11027 GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION.html The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 14/25 Gene Ontology BP GO:0021694 2.44659691217674e-07 5.53132660470759e-07 4010 2772.72727272727 3154 2.22417925841841e-08 1562 2.39478902881781 -1.69842919701062 -1 18.0193821319822 4006 3345 1772 3154 1993 3377 1957 2166 3650 1562 3518 3481 M16706 GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. 197/236 Gene Ontology BP GO:2001235 3.85000854682652e-08 4.02645553947883e-07 4285 2812.36363636364 3154 3.50000783109256e-09 130 1.93102342422005 1.93498256472531 1 14.8319427851973 4285 3134 2630 1180 130 3154 4547 3331 1540 3368 3637 3482 M13019 GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION.html The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. 14/25 Gene Ontology BP GO:0021702 2.44659691217674e-07 5.53132660470759e-07 4010 2762.72727272727 3155 2.22417925841841e-08 1570 2.39478902881781 -1.69842919701062 -1 18.0193821319822 4007 3346 1773 3155 1994 3378 1958 2039 3651 1570 3519 3483 M12659 GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. 24/31 Gene Ontology BP GO:0052312 2.6282780499619e-06 3.43908261149402e-06 3700 3159.36363636364 3156 2.38934653626993e-07 1834 1.494152678761 -1.30548930786513 -1 9.76982305333488 3697 3272 3156 3069 3523 3040 1834 2783 3589 2883 3907 3484 M10125 GO_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION.html A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. 924/1244 Gene Ontology BP GO:0051276 1.00090477266695e-06 1.49173923998057e-06 365 2403.36363636364 3157 1.0009052234819e-07 365 1.37400701293152 1.5082443535734 1 9.57873571345344 365 3872 4226 3644 3157 423 622 992 3519 4515 1102 3485 M12731 GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. 178/268 Gene Ontology BP GO:0006109 3.11214821974337e-07 6.41665607687432e-07 3160 3057.36363636364 3157 2.82922605453812e-08 2197 1.79943848850773 -1.49661080202076 -1 13.3738005839501 3157 3645 2846 3549 2197 2495 2230 3822 3371 3176 3143 3486 M13683 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. 17/18 Gene Ontology BP GO:1902165 8.03440512705061e-05 8.65773206488339e-05 2870 2905.72727272727 3157 7.30427141701434e-06 785 1.96662613354574 1.57361134450306 1 9.55965189492414 2866 3336 3157 2319 4289 2005 1696 4403 785 3922 3185 3487 M10580 GO_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. 16/22 Gene Ontology BP GO:0046209 1.10555605525565e-06 1.61309260743321e-06 2695 3265.27272727273 3158 1.00505146438738e-07 2410 1.62827373783469 -2.07414913322443 -1 11.3034928738687 3412 2691 2767 3531 3158 3742 4609 2432 4472 2410 2694 3488 M15642 GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that modulates the frequency, rate or extent of response to oxidative stress. 71/89 Gene Ontology BP GO:1902882 1.19890797718043e-07 4.10861475461767e-07 3815 3217.45454545455 3158 1.08991640228719e-08 1240 1.73852866498033 1.98541261184943 1 13.324707049277 3811 2853 2902 1456 1240 4275 4570 4629 2070 3158 4428 3489 M10659 GO_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 120/162 Gene Ontology BP GO:0042157 2.97771806428241e-07 6.21036403097538e-07 3670 2945.63636363636 3159 2.70701678847188e-08 925 1.84212175996156 2.19665320271708 1 13.7250908059642 3666 3159 3049 1996 2172 3701 4125 3478 925 3335 2796 3490 M11211 GO_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. 178/263 Gene Ontology BP GO:0042593 3.38211451780397e-07 6.79489587709061e-07 3125 3263.18181818182 3159 3.07465003431357e-08 2261 1.69885063964835 -1.58288966188768 -1 12.5693496538191 3124 4350 3300 3570 2261 2663 2471 4369 3159 3517 3111 3491 M16751 GO_HISTONE_H3_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_DEACETYLATION.html The modification of histone H3 by the removal of one or more acetyl groups. 21/23 Gene Ontology BP GO:0070932 1.49690474476109e-06 2.08785904597523e-06 2635 3084.81818181818 3159 1.36082342115717e-07 1355 1.07590803367191 -1.18433025942262 -1 7.28824882718364 2631 3003 3792 2622 3304 3159 3641 2587 4080 3759 1355 3492 M12760 GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. 15/16 Gene Ontology BP GO:0070243 1.11148826514808e-06 1.62073171348607e-06 4435 2631.63636363636 3160 1.01044438790613e-07 328 2.57465988321261 2.77592759773041 1 17.9267673639766 4433 1095 1507 1212 3160 3885 4475 3201 328 1780 3872 3493 M14445 GO_CARBOHYDRATE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. 178/263 Gene Ontology BP GO:0033500 3.38211451780397e-07 6.79489587709061e-07 3125 3263 3160 3.07465003431357e-08 2262 1.69885063964835 -1.58288966188768 -1 12.5693496538191 3125 4351 3301 3571 2262 2664 2472 4357 3160 3518 3112 3494 M14873 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. 32/43 Gene Ontology BP GO:0048873 2.19039194862586e-06 2.92198788330164e-06 3460 2989.45454545455 3160 1.99126739041342e-07 2018 1.4342005653192 -1.53643956701482 -1 9.49642456124054 3443 2018 2780 2754 3457 3458 2194 2951 3272 3160 3397 3495 M10349 GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION.html A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. 65/78 Gene Ontology BP GO:0061572 1.11227331230063e-06 1.62136833400215e-06 3410 2995.63636363636 3161 1.0111580678571e-07 665 1.78336010359359 1.86916853168344 1 12.3851170890594 3409 2855 2692 2233 3161 3560 4360 3519 665 2708 3790 3496 M11643 GO_PEPTIDYL_CYSTEINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_CYSTEINE_MODIFICATION.html The modification of peptidyl-cysteine. 19/37 Gene Ontology BP GO:0018198 0.000301649633432852 0.000315552100801048 1805 2896.90909090909 3161 2.74264546910857e-05 756 2.34316833551567 -2.20195835315566 -1 9.8180500551761 1802 4267 2534 3782 4426 2281 756 3161 3955 3252 1650 3497 M16866 GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. 13/14 Gene Ontology BP GO:0046498 5.25963214043173e-07 9.19003693181706e-07 4425 3039.81818181818 3161 4.78148490715857e-08 74 2.15081437979341 1.07715805858421 1 15.5995961210371 4423 4067 3161 2916 2617 4643 4576 548 74 3611 2802 3498 M13476 GO_DETOXIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETOXIFICATION.html Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. 61/97 Gene Ontology BP GO:0098754 4.89250842249545e-06 6.09011281162957e-06 2520 2990.36363636364 3162 4.44774482074511e-07 1641 1.81278231256759 -1.75867815318606 -1 11.3310945874506 2517 3683 2920 3419 3714 2740 1641 1928 3950 3220 3162 3499 M15019 GO_NUCLEAR_ENVELOPE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. 92/100 Gene Ontology BP GO:0006998 1.71858954150514e-07 4.60329573101057e-07 2580 3245 3163 1.56235425068857e-08 1656 1.2673615585464 1.40513167632417 1 9.60993345980081 2576 3909 4019 4533 1656 2564 2702 3163 2866 4320 3387 3500 M12310 GO_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 1662/2794 Gene Ontology BP GO:0009605 1.27963996792304e-22 1.80429235477148e-20 3970 2574.18181818182 3167 1.27963996792304e-23 5 2.27639908410929 2.40961379174419 1 54.2528311168584 3966 1300 4362 5 918 4037 3167 4325 2261 17 3958 3501 M15960 GO_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REPOLARIZATION.html The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. 13/28 Gene Ontology BP GO:0086009 1.12667407977557e-06 1.63927907854776e-06 3420 2443 3167 1.02424968797589e-07 522 3.1987208107365 2.8013686057184 1 22.2777989027908 3417 1097 522 539 3167 3591 4323 3998 1474 736 4009 3502 M11326 GO_DEVELOPMENTAL_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_INDUCTION.html A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). 21/39 Gene Ontology BP GO:0031128 1.5747114268997e-05 1.80961528015912e-05 3360 2988.27272727273 3169 1.43156608949942e-06 1383 1.71644439695298 -1.28686764489749 -1 9.74164480728163 3356 2984 2594 1685 4022 3241 3219 4230 2988 3169 1383 3503 M14342 GO_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASOCONSTRICTION.html Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. 55/92 Gene Ontology BP GO:0019229 2.14391902456663e-07 5.12148364863292e-07 4595 2674.81818181818 3169 1.94901748499402e-08 436 2.44641425135963 2.41547353256982 1 18.5089704251503 4594 436 581 2104 1875 4010 3860 3169 3778 647 4369 3504 M15302 GO_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. 21/24 Gene Ontology BP GO:0055070 1.78647540055063e-06 2.44556341240426e-06 1670 2875.36363636364 3169 1.62406986475594e-07 1229 1.63808147086258 -1.54831046704287 -1 11.0141763161302 1668 3541 3169 3031 3368 1862 1229 4313 3249 3446 2753 3505 M11347 GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM.html The process in which an organism effects a change in the structure or processes of a second organism. 98/206 Gene Ontology BP GO:0035821 3.60357472147122e-07 7.04915207432408e-07 3435 2798.90909090909 3170 3.27597755612069e-08 1228 1.8895987103292 -2.0375087265809 -1 13.9557452391265 3432 3170 2936 2271 2321 3322 2036 3287 1228 3404 3381 3506 M11813 GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response. 8/23 Gene Ontology BP GO:0016056 5.86193844202382e-07 9.9764446125592e-07 3385 3047.27272727273 3171 5.86193998832889e-08 1104 1.75498374486493 1.97419706268362 1 12.6340521043242 3383 2298 4326 2027 2758 3956 4072 3099 1104 3326 3171 3507 M13952 GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE.html Any process that modulates the frequency, rate or extent of stem cell population maintenance. 16/22 Gene Ontology BP GO:2000036 2.48591767758561e-06 3.2675070490977e-06 3565 2909.09090909091 3171 2.25992771507637e-07 1496 1.33471068462448 -0.801124954842803 -1 8.75216948510501 3563 3030 3171 2799 3506 4288 3342 1521 1496 3237 2047 3508 M16537 GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. 200/257 Gene Ontology BP GO:0014074 7.63040105738102e-08 4.02645553947883e-07 3810 2547.27272727273 3171 6.93672847457373e-09 409 2.14368409958674 2.24538339567956 1 16.4767006918048 3806 1695 573 2260 667 3249 4213 4172 3171 409 3805 3509 M10962 GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. 18/28 Gene Ontology BP GO:0032780 3.35263979635204e-06 4.29865885159164e-06 4590 3053.45454545455 3172 3.04785900503805e-07 169 3.79598332281751 -3.7150769224126 -1 24.5346169787916 4589 3555 1931 3172 3605 4383 3039 2460 169 3143 3542 3510 M10729 GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 351/467 Gene Ontology BP GO:0071496 2.48791524089699e-07 5.59143257290898e-07 4520 2979.54545454545 3174 2.26174138386187e-08 601 2.2319526899559 2.40930062560038 1 16.7744634792739 4519 3413 601 1408 2007 4653 3174 4628 2704 1297 4371 3511 M12131 GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. 18/20 Gene Ontology BP GO:2000647 0.000218485443739483 0.000230211225027132 3365 2840.36363636364 3175 1.98642858989281e-05 1210 2.16310103058902 2.67676202844383 1 9.41389622256919 3364 3315 2393 2773 4397 3175 3335 1323 2507 3452 1210 3512 M13129 GO_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction. 23/38 Gene Ontology BP GO:0019098 9.39946804548775e-06 1.11286831591996e-05 3175 3225.54545454545 3175 8.54500745892606e-07 2011 2.04849661057727 1.68978224710816 1 12.1692120122806 3175 4002 3113 3030 3903 2011 2466 3545 3128 3666 3442 3513 M15871 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. 81/118 Gene Ontology BP GO:1900076 1.05671659170924e-07 4.02645553947883e-07 4600 3146.36363636364 3175 9.60651493150963e-09 1084 1.969278742173 2.30415230369357 1 15.1278166535766 4596 2437 1736 2515 1084 4278 3848 4355 3175 2107 4479 3514 M10752 GO_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 47/52 Gene Ontology BP GO:0034405 6.30916297720414e-07 1.05263043393331e-06 4465 3287.63636363636 3176 5.73560435140679e-08 1286 1.93634010770234 1.95251627117343 1 13.8957038210341 4461 2501 2350 2582 2746 4527 3176 4291 3625 1286 4619 3515 M12488 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. 33/44 Gene Ontology BP GO:1904036 1.157194265758e-06 1.67582474901089e-06 3595 2932.27272727273 3176 1.05199534039966e-07 1449 2.28277356488026 2.12914387243226 1 15.8426779944691 3595 3503 1449 2008 3176 3536 4521 2436 2485 1468 4078 3516 M13169 GO_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium. 52/89 Gene Ontology BP GO:0003341 1.39293422498908e-07 4.25357343137389e-07 3630 3146.18181818182 3178 1.26630392107544e-08 1420 2.33269901384419 2.15962474612406 1 17.8713466683661 3626 4171 2243 4134 1420 3149 4006 2081 2317 3178 4283 3517 M14307 GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. 95/122 Gene Ontology BP GO:0006081 2.41337304799997e-07 5.48853038928409e-07 2385 3282.36363636364 3180 2.19397573885825e-08 1982 1.82828773494141 -1.97676687891318 -1 13.7398956993448 2385 3180 3129 3960 1982 3913 3951 3028 3858 3663 3057 3518 M15126 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. 33/42 Gene Ontology BP GO:1901797 4.73599479333197e-06 5.91427369118992e-06 3625 3092.45454545455 3180 4.30545908059695e-07 2458 1.80096305385964 2.28986879000698 1 11.2842587960235 3622 2553 2667 3220 3701 3087 3191 2458 2625 3713 3180 3519 M13749 GO_POSITIVE_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_URINE_VOLUME.html Any process that increases the amount of urine excreted from the body over a unit of time. 12/17 Gene Ontology BP GO:0035810 1.22460390532115e-07 4.14338946095474e-07 3605 2804.90909090909 3183 1.11327633953389e-08 1203 2.70891351663627 2.43414829459759 1 20.8075600521999 3604 1203 1443 2913 1260 3950 4473 3963 3261 1601 3183 3520 M15838 GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 23/27 Gene Ontology BP GO:0033598 0.0293451516896531 0.0295996078066238 3190 3183.90909090909 3186 0.00270400429604962 1458 2.08752244081556 -1.44236538743195 -1 3.75650107747041 3186 2968 2248 1458 4597 3223 2096 3359 4223 3101 4564 3521 M11959 GO_HEXOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 54/78 Gene Ontology BP GO:0019320 1.08607591245763e-07 4.02645553947883e-07 3480 3000.45454545455 3187 9.87341787340034e-09 1125 1.85356614784148 1.70190920400647 1 14.2328735518835 3477 3474 2839 3476 1125 3187 3093 1775 3015 3306 4238 3522 M11818 GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrate derivative. 962/1241 Gene Ontology BP GO:1901135 6.24476576943979e-08 4.02645553947883e-07 2935 3014.45454545455 3188 6.24476594492674e-09 542 1.86826043761737 1.96664100019036 1 14.3465219697172 2934 2322 4327 4094 542 3188 3580 4024 2312 1950 3886 3523 M14576 GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of adherens junction organization. 42/47 Gene Ontology BP GO:1903393 1.18044077014254e-06 1.70260102401526e-06 2165 2505.27272727273 3188 1.07312854865911e-07 511 2.17684938788483 2.55688238310281 1 15.0846520550367 2161 543 783 1434 3188 3417 4247 3995 3455 511 3824 3524 M16601 GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 243/322 Gene Ontology BP GO:0034599 3.8408065790765e-07 7.37233164478964e-07 4600 3294.63636363636 3189 3.49164295419346e-08 2373 1.81411403326169 1.93851407052174 1 13.3514232425165 4600 3418 2525 2606 2373 3989 4433 2642 3177 3189 3289 3525 M12719 GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-beta production. 48/71 Gene Ontology BP GO:0032728 2.64764938009928e-06 3.46248245238953e-06 3530 3143.63636363636 3191 2.40695687862705e-07 1639 1.9534217394983 -1.78598910301104 -1 12.7975373232632 3191 3940 2778 3774 3526 3977 3179 1639 2056 3530 2990 3526 M10407 GO_RESPONSE_TO_ORGANOPHOSPHORUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANOPHOSPHORUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. 175/232 Gene Ontology BP GO:0046683 9.81688806255576e-08 4.02645553947883e-07 4335 2756.27272727273 3194 8.924444091461e-09 391 2.19652333286651 -2.05047698351754 -1 16.8853693211418 4332 1733 436 2232 984 4406 3587 4492 3194 391 4532 3527 M12195 GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. 20/31 Gene Ontology BP GO:0070193 0.00027190750608387 0.000285144382647791 885 2695.63636363636 3194 2.47219198294136e-05 139 2.00534361263101 2.00534361263101 1 8.49442189259943 883 4513 3194 3595 4416 573 139 2308 4432 3882 1717 3528 M15665 GO_ASPARTATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. 10/12 Gene Ontology BP GO:0006531 6.06793349091544e-05 6.59521012222134e-05 1580 2633.81818181818 3194 5.51645532743832e-06 935 1.43723271272703 -1.58444681396736 -1 7.16399803995538 1579 3392 3326 3552 4250 1567 987 1865 4325 3194 935 3529 M10976 GO_ERYTHROCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_HOMEOSTASIS.html Any process of regulating the production and elimination of erythrocytes within an organism. 89/106 Gene Ontology BP GO:0034101 1.20338511949064e-06 1.73033095209826e-06 1040 2585 3195 1.09398707066788e-07 493 1.37033698289974 -1.34947503292578 -1 9.44608645436384 1040 4148 3722 4200 3195 1111 493 745 3443 4108 2230 3530 M14499 GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 142/172 Gene Ontology BP GO:0044262 3.53658635396156e-08 4.00785157005513e-07 3105 2990.90909090909 3195 3.21507855528508e-09 104 1.57321360201084 -1.5311958740679 -1 12.0684006494448 3103 3435 3565 3931 104 3195 3128 2565 2164 4233 3477 3531 M14469 GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 89/134 Gene Ontology BP GO:0051897 2.02815134705484e-07 4.99047499621692e-07 4005 2886.09090909091 3197 1.84377412184318e-08 1342 2.20499113276312 -2.21720549571042 -1 16.7022728736369 4004 2431 1342 1612 1818 4652 3330 3197 3863 1757 3741 3532 M16935 GO_ACTIVATION_OF_MAPKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). 63/76 Gene Ontology BP GO:0000186 4.63021672223984e-07 8.40141046894164e-07 2890 3039.09090909091 3197 4.20928881521445e-08 1901 1.78494403270537 -1.63769897629763 -1 13.0125830086897 2886 3197 2722 3264 2513 3338 1988 4423 1901 3687 3511 3533 M16030 GO_MATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING_BEHAVIOR.html The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. 15/27 Gene Ontology BP GO:0007617 1.14307598185344e-05 1.33602927494702e-05 3200 3004.54545454545 3198 1.03916538280976e-06 1369 1.77629891192857 1.48420816432434 1 10.3680137984901 3198 2701 3166 3769 3958 1857 1493 4280 3780 3479 1369 3534 M11991 GO_RESPONSE_TO_METHYLMERCURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METHYLMERCURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. 12/14 Gene Ontology BP GO:0051597 6.15889311965675e-08 4.02645553947883e-07 3620 2817.18181818182 3199 5.59899390188616e-09 428 1.91058468754062 1.89984723365099 1 14.6738657279483 3620 3065 2146 3199 428 3454 3338 3808 1453 2081 4397 3535 M16592 GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species. 15/27 Gene Ontology BP GO:0044705 1.14307598185344e-05 1.33602927494702e-05 3200 3014.36363636364 3199 1.03916538280976e-06 1370 1.77629891192857 1.48420816432434 1 10.3680137984901 3199 2702 3167 3770 3959 1858 1494 4377 3781 3481 1370 3536 M11841 GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 12/17 Gene Ontology BP GO:0060218 3.31438089342429e-06 4.25899317787993e-06 3450 3158 3201 3.01307807879228e-07 1897 1.87274822171806 -1.40925424111059 -1 12.0611072952729 3448 2723 2587 2497 3597 4074 4156 4478 1897 2080 3201 3537 M15584 GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. 14/16 Gene Ontology BP GO:0070234 1.22825402746332e-06 1.76282109493733e-06 4635 2783.27272727273 3201 1.1165951938134e-07 162 3.0551344421245 3.13140622220681 1 21.1565632453933 4634 1098 1260 1607 3201 3942 4449 3696 162 2049 4518 3538 M11435 GO_OXALOACETATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALOACETATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. 11/12 Gene Ontology BP GO:0006107 3.87437454985108e-05 4.28002487665173e-05 2170 3060.27272727273 3202 3.52222071122105e-06 1284 1.35862060978589 -1.71599160116357 -1 7.07506589301335 2167 3844 3425 3956 4179 3202 3010 1284 2692 3748 2156 3539 M11499 GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that activates or increases the frequency, rate or extent of membrane depolarization. 15/17 Gene Ontology BP GO:1904181 1.08164097190187e-05 1.26868551607244e-05 4205 3337.36363636364 3202 9.83314808982049e-07 2079 2.15596430674631 1.63335201304017 1 12.6646427302117 4203 3032 2079 3202 3943 4293 3819 4466 2121 2665 2888 3540 M13388 GO_AMINO_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_METABOLIC_PROCESS.html The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. 34/46 Gene Ontology BP GO:0006040 1.42804524216796e-06 2.00322415188649e-06 3640 3329.72727272727 3202 1.29822379011759e-07 2395 1.87335078275431 -1.65296643326529 -1 12.8071888005173 3640 4214 3162 2974 3286 3153 2395 3291 3202 3092 4218 3541 M14488 GO_NEGATIVE_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JNK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. 53/66 Gene Ontology BP GO:0046329 2.06030056335915e-06 2.77309184880246e-06 2735 3070.45454545455 3205 1.87300226621244e-07 1954 1.54979732519053 -1.26750545137448 -1 10.3127096950927 2735 3205 3257 4001 3428 2541 1954 3769 2397 4196 2292 3542 M12430 GO_DNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_MODIFICATION.html The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. 64/83 Gene Ontology BP GO:0006304 1.02982885937575e-06 1.5226544908406e-06 3080 3511.63636363636 3206 9.36208492221003e-08 2402 1.2721128170775 1.39337025453651 1 8.8470510065522 3076 4409 3968 4405 3109 2647 2402 3206 3829 4432 3145 3543 M11047 GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. 168/342 Gene Ontology BP GO:0050851 1.45872510661805e-07 4.33702742561904e-07 2735 3152 3207 1.32611382121803e-08 1467 1.52159654169355 -1.52341633292464 -1 11.6059754256842 2733 3648 3715 2629 1467 3945 3207 2661 3948 3869 2850 3544 M14467 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 38/39 Gene Ontology BP GO:1902229 1.11311806206489e-05 1.30265048862876e-05 3955 3178 3208 1.01193063097055e-06 1296 2.15872195734933 2.17938319344827 1 12.6510179320455 3789 3955 2735 3208 3954 2962 3036 2715 1296 3416 3892 3545 M15500 GO_POSITIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 995/1446 Gene Ontology BP GO:0051050 6.97670387252162e-08 4.02645553947883e-07 3700 2477.63636363636 3212 6.97670409155641e-09 190 2.17100464452956 -2.00252626168408 -1 16.6880029564574 3699 1346 4559 402 677 3710 3212 3479 2137 190 3843 3546 M15876 GO_PLATELET_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DEGRANULATION.html The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. 113/171 Gene Ontology BP GO:0002576 2.14743490188756e-07 5.12148364863292e-07 3215 3058 3212 1.95221373772742e-08 693 2.46388307098212 2.57664786857866 1 18.6418704100153 3212 3165 693 3651 1879 3207 4028 4156 3710 1832 4105 3547 M14326 GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS.html The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. 13/16 Gene Ontology BP GO:0060670 5.13594281053067e-06 6.36928088949873e-06 3470 3054.09090909091 3216 4.66904981866208e-07 1433 2.01987157490633 -1.66629831313985 -1 12.5897520875289 3468 3579 2475 2496 3728 4167 4303 3216 1433 3215 1515 3548 M14992 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 1393/1992 Gene Ontology BP GO:0048585 4.65614351512725e-11 1.25604458368475e-09 3805 2557.27272727273 3217 4.65614351522481e-12 98 2.02006397016894 2.23485235241237 1 21.6427068775511 3805 1318 4528 371 715 3217 4500 3295 2527 98 3756 3549 M12800 GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. 32/41 Gene Ontology BP GO:2000272 1.16128025612246e-07 4.08548528935279e-07 4435 2967.63636363636 3219 1.0557093794738e-08 703 1.59726559931134 -1.54132259388822 -1 12.2383866465726 4434 703 2864 3219 1206 4424 3382 3506 2316 2891 3699 3550 M16959 GO_FRUCTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRUCTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. 22/26 Gene Ontology BP GO:0006000 1.2646770627641e-06 1.80784711921394e-06 3220 3068.81818181818 3219 1.1497070816076e-07 773 2.52340999156438 1.86344150646541 1 17.423066767557 4266 3291 2446 3424 3219 3673 2700 773 3219 3570 3176 3551 M12670 GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 133/262 Gene Ontology BP GO:0038095 1.28212904902514e-06 1.82830109258779e-06 3155 3358 3222 1.16557254202956e-07 2552 1.30724648990815 -1.32965111779852 -1 8.96863246717316 2552 3152 3928 3352 3228 3851 3222 3157 3154 4373 2969 3552 M14080 GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 45/58 Gene Ontology BP GO:0010828 9.58178736598819e-07 1.44425191493175e-06 4220 3352.45454545455 3222 8.71071958109278e-08 2390 1.84883917661881 -1.78752031135963 -1 12.955970679768 4220 2884 2390 4141 3051 3822 3435 2429 3222 3089 4194 3553 M15167 GO_EMBRYONIC_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_EYE_MORPHOGENESIS.html The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. 39/53 Gene Ontology BP GO:0048048 5.09359740857356e-06 6.32182148362037e-06 3520 3208.81818181818 3222 4.63055381970268e-07 1660 2.25447618751933 2.77385475359947 1 14.0728448636962 3517 3222 1660 2719 3726 3648 4626 3371 2894 3048 2866 3554 M16293 GO_UTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. 9/13 Gene Ontology BP GO:0046051 1.13935741774448e-05 1.33235236611336e-05 1605 3192.90909090909 3224 1.1393632593956e-06 1603 0.766029866709815 0.845652017859484 1 4.41376319490502 1603 2740 4613 3551 3968 2405 2050 2613 4193 4162 3224 3555 M14343 GO_CELLULAR_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 74/117 Gene Ontology BP GO:0071398 1.6689336194764e-07 4.53963284590687e-07 3845 3014 3225 1.51721249643886e-08 1167 2.36067082291667 2.40579148497811 1 18.0061783631624 3841 2848 1167 3225 1625 4091 4107 4193 2673 1745 3639 3556 M12252 GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of muscle contraction. 40/61 Gene Ontology BP GO:0045933 3.41496347035957e-07 6.84316323323991e-07 4220 2993.90909090909 3226 3.10451272768135e-08 953 2.79707180533658 -2.90348982380401 -1 20.750957658551 4217 3226 953 3680 2266 4515 2854 3268 2992 1085 3877 3557 M16716 GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. 63/88 Gene Ontology BP GO:0009185 4.44699613075251e-07 8.18764774416964e-07 2375 3133.81818181818 3226 4.04272457241056e-08 2186 1.61253367795628 1.6317660110841 1 11.7675623652156 2373 4162 3424 3269 2477 2382 2186 4245 3226 3686 3042 3558 M12929 GO_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BINDING.html Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 126/163 Gene Ontology BP GO:0051101 7.56422720363634e-06 9.0829288202632e-06 1175 2797.90909090909 3228 6.87659382884652e-07 1172 1.59289332907129 -1.64740799779155 -1 9.60972230878521 1172 3656 3270 3635 3850 1876 1328 2626 4051 3228 2085 3559 M14399 GO_GDP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. 15/17 Gene Ontology BP GO:0046710 6.5729435687697e-05 7.11915885136998e-05 3800 3127.36363636364 3229 5.97558177902352e-06 2026 1.96479707190201 2.37530226530099 1 9.75258559245397 3797 3344 2547 3229 4266 3540 3953 2026 2777 2233 2689 3560 M13093 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. 33/45 Gene Ontology BP GO:1904037 2.44006398068535e-06 3.21359119788535e-06 3195 3311.18181818182 3230 2.21824244273936e-07 1876 3.04102529627726 -2.84387393939465 -1 20.0992755164871 3195 3975 1876 2519 3499 4618 4355 2531 3713 3230 2912 3561 M12262 GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 26/62 Gene Ontology BP GO:0045072 2.62518358517293e-06 3.43599978109976e-06 4090 2949.18181818182 3233 2.38653337974414e-07 720 2.53095751998156 2.39631704663629 1 16.6218191183695 4086 3743 1898 3233 3522 4564 3484 720 1512 2796 2883 3562 M14177 GO_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 102/179 Gene Ontology BP GO:0070542 2.57382495268584e-07 5.67433145203964e-07 4050 3178.09090909091 3234 2.33984113982085e-08 1453 2.24914814675303 -2.09155836620999 -1 16.8871049608426 4212 3169 1453 3234 2051 4048 3310 4472 2983 1977 4050 3563 M10506 GO_ICOSANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. 37/58 Gene Ontology BP GO:0046456 1.25960331560813e-07 4.15964104153627e-07 3240 2837.09090909091 3236 1.14509398884212e-08 1300 2.06469159642484 -2.12799718742744 -1 15.8304672965498 3236 2530 1747 3438 1300 3958 2236 3348 4032 1420 3963 3564 M13229 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter. 27/31 Gene Ontology BP GO:0006356 1.16062909196701e-06 1.67975339499922e-06 2815 3017.63636363636 3237 1.05511791297038e-07 340 2.24854836810687 1.74649261230897 1 15.6008426404816 2814 3518 2863 3237 3178 2807 3292 4281 340 3484 3380 3565 M15016 GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 40/45 Gene Ontology BP GO:0002753 1.95163404883027e-06 2.63981198523466e-06 150 2115.54545454545 3237 1.77421434558131e-07 90 1.52010846601809 -1.54523317208684 -1 10.1525068527957 149 3953 3517 3584 3409 343 90 315 3237 3763 911 3566 M15813 GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of fatty acid derivative. 37/58 Gene Ontology BP GO:1901570 1.25960331560813e-07 4.15964104153627e-07 3240 2841.72727272727 3237 1.14509398884212e-08 1301 2.06469159642484 -2.12799718742744 -1 15.8304672965498 3237 2531 1748 3439 1301 3959 2237 3386 4033 1424 3964 3567 M16525 GO_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GTPASE_ACTIVITY.html Any process that modulates the rate of GTP hydrolysis by a GTPase. 620/772 Gene Ontology BP GO:0043087 4.57019379376279e-08 4.02645553947883e-07 3885 2648 3238 4.57019388775282e-09 250 1.84806582132996 -1.66070269457307 -1 14.1903329857767 3881 1411 4630 1462 250 3500 3238 4260 2168 430 3898 3568 M15947 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS.html Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. 33/37 Gene Ontology BP GO:1901522 5.76947129154891e-07 9.86598674001362e-07 3410 3105.90909090909 3239 5.24497527689617e-08 2187 1.32406617938153 1.17118746995661 1 9.51435781187017 3407 3239 3492 2623 2679 3183 3059 2187 3534 3508 3254 3569 M15178 GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. 33/54 Gene Ontology BP GO:0032727 3.48170944216685e-06 4.45188074591986e-06 3600 2804.09090909091 3240 3.16519541119611e-07 951 2.2617199890587 2.22152305451223 1 14.5349781968938 3596 3240 1976 2297 3613 4343 3437 1374 951 2659 3359 3570 M13932 GO_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. 398/504 Gene Ontology BP GO:0051052 9.20962635395074e-07 1.40361583442295e-06 2070 3255.63636363636 3243 8.37239109934642e-08 2020 1.54470268842787 1.60480523122309 1 10.8309149463418 2070 4339 4000 4078 3017 2174 2020 3648 2920 4303 3243 3571 M11175 GO_RENAL_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. 9/19 Gene Ontology BP GO:0072087 1.19787048537307e-06 1.72346671875104e-06 3940 3242.54545454545 3244 1.19787113107572e-07 1249 2.02656407637222 2.19293255299429 1 14.0231645609337 3939 1249 4282 2285 3244 3229 3920 3514 2907 2448 4651 3572 M11710 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. 33/53 Gene Ontology BP GO:0036092 3.8904054170724e-07 7.45247278947627e-07 3230 3290 3244 3.53673282276244e-08 2381 1.5926414852547 -1.39287065138425 -1 11.6998273222626 3228 3244 2776 3593 2381 3121 3565 4022 2807 3865 3588 3573 M13549 GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. 37/70 Gene Ontology BP GO:0071622 5.54137882066405e-07 9.54257426075122e-07 4220 2722.63636363636 3246 5.03761837857434e-08 563 2.52051066506974 2.19830674156195 1 18.2488210807646 4218 622 590 1342 2659 4249 4135 4081 3246 563 4244 3574 M14287 GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. 415/631 Gene Ontology BP GO:1901361 7.0268939496458e-08 4.02645553947883e-07 2105 3126.18181818182 3249 6.3880856128071e-09 574 1.465428067531 -1.39072367306388 -1 11.2309401885791 2105 4340 4113 4271 574 2619 2023 3387 3207 4500 3249 3575 M10405 GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. 19/30 Gene Ontology BP GO:0001516 7.34997537648604e-07 1.17266030051936e-06 3245 3288.63636363636 3250 6.68179802912629e-08 1787 2.39205777891115 -3.0768973150462 -1 17.0546204541027 3245 4507 2388 3990 2871 3413 1787 2915 4164 3250 3645 3576 M15725 GO_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_NUCLEATION.html The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. 22/25 Gene Ontology BP GO:0045010 1.38667646960425e-06 1.95402956180151e-06 3275 2700.45454545455 3250 1.26061576694326e-07 875 1.78840046127073 -2.34609424062894 -1 12.2451116970372 3250 3274 2966 2492 3272 3952 3779 875 907 3271 1667 3577 M10966 GO_CELLULAR_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 19/27 Gene Ontology BP GO:0071285 7.35412890314133e-06 8.84205730912573e-06 4540 3155.45454545455 3251 6.68559407866775e-07 1094 2.29172110111378 2.36385828478529 1 13.9031821210919 4536 3000 2367 2931 3845 4136 4246 1094 1174 3251 4130 3578 M13390 GO_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINESIS.html Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. 63/100 Gene Ontology BP GO:0032465 1.65402480778545e-07 4.52287618430271e-07 3540 3220.45454545455 3251 1.50365902921811e-08 1610 1.4730630083286 1.70924485342823 1 11.2000382064604 3540 1893 3251 3880 1610 4085 4580 4000 2789 3175 2622 3579 M12680 GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING.html Any process that activates or increases the frequency, rate or extent of telomere capping. 19/20 Gene Ontology BP GO:1904355 2.89027004174895e-07 6.08250859532242e-07 4650 2755.18181818182 3253 2.62751856496443e-08 79 1.9985302168042 -1.94333424336593 -1 14.921020731331 4650 1037 2352 1637 2150 3496 3412 4312 79 3253 3929 3580 M14361 GO_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. 11/18 Gene Ontology BP GO:0030851 0.00294149065531217 0.00300807824597089 2830 3174.45454545455 3254 0.000267766447921063 368 2.13334338013272 1.30899091471162 1 6.40320708067636 2830 4586 3254 4221 4533 1544 368 2730 4008 3750 3095 3581 M14115 GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 16/23 Gene Ontology BP GO:0014733 3.16963367333357e-07 6.4770775063773e-07 4460 3460.54545454545 3255 2.88148557272389e-08 2218 1.47089175950245 -1.47953293865816 -1 10.9059340378916 4460 3018 3183 3255 2218 4342 4383 3209 3538 2417 4043 3582 M14208 GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. 16/24 Gene Ontology BP GO:0002381 6.76685880343511e-06 8.17823221100872e-06 1440 2955.45454545455 3255 6.15170874302995e-07 1190 1.0241081235667 1.05912525070488 1 6.19798638533504 1440 3353 3638 3037 3822 1769 1190 3255 3992 4073 2941 3583 M15937 GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. 21/21 Gene Ontology BP GO:0043162 3.49427373186496e-06 4.46549180839541e-06 1020 2259.90909090909 3256 3.17661752895826e-07 220 1.00245830965099 -0.990093783955314 -1 6.38338238241578 1018 3543 3725 3561 3615 610 220 566 3256 3951 794 3584 M12996 GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS.html The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. 14/15 Gene Ontology BP GO:0019184 0.018708093290229 0.018907202015516 4440 3320.81818181818 3257 0.00171537281997336 1569 1.75936556736921 -1.75465726043887 -1 3.56398652330485 4438 2693 2748 3686 4585 3257 2476 2386 4317 1569 4374 3585 M13503 GO_MEGAKARYOCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. 19/21 Gene Ontology BP GO:0035855 1.29580960715582e-06 1.84441789602204e-06 4560 3442.63636363636 3257 1.17800942763088e-07 2687 1.8863663514297 -1.60329502262143 -1 12.9787183593982 4559 4254 2724 3022 3235 4237 3237 3305 2687 3257 3352 3586 M10343 GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. 66/89 Gene Ontology BP GO:1904035 4.13810503263079e-07 7.78592912124184e-07 4340 3055.36363636364 3258 3.7619143736279e-08 1209 2.55658669010695 -2.68281351293034 -1 18.7846774874907 4336 3465 1209 2426 2424 4086 4357 2335 3258 1944 3769 3587 M15560 GO_EPITHELIAL_STRUCTURE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_STRUCTURE_MAINTENANCE.html A tissue homeostatic process required for the maintenance of epithelial structure. 26/49 Gene Ontology BP GO:0010669 1.25548933666641e-06 1.79581674869622e-06 3540 3047.54545454545 3260 1.14135459376894e-07 1197 2.84137117700312 3.06050730942148 1 19.6413902379725 3537 3741 1197 2863 3213 2399 3260 4171 3296 1442 4404 3588 M16193 GO_PROTEIN_TETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TETRAMERIZATION.html The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. 124/176 Gene Ontology BP GO:0051262 4.67482193334159e-07 8.45651100068041e-07 3480 3131.81818181818 3260 4.2498390242761e-08 1523 1.71119582623751 1.99186753338184 1 12.4648152203769 3480 2399 3211 3695 2521 2500 3897 3260 1523 3822 4142 3589 M16690 GO_PROSTANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. 19/30 Gene Ontology BP GO:0046457 7.34997537648604e-07 1.17266030051936e-06 3250 3288.54545454545 3260 6.68179802912629e-08 1788 2.39205777891115 -3.0768973150462 -1 17.0546204541027 3246 4508 2389 3991 2872 3414 1788 2895 4165 3260 3646 3590 M13622 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 13/15 Gene Ontology BP GO:0010867 6.87337958873536e-06 8.29619590827124e-06 2150 2858.27272727273 3261 6.24854642097992e-07 1338 1.44075797386137 -1.56360991088602 -1 8.75063571722105 2150 4081 3449 3261 3827 1403 2015 4650 1368 3899 1338 3591 M14696 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. 12/33 Gene Ontology BP GO:0034723 0.000425349392731325 0.000442722321817261 1060 2902.90909090909 3261 3.86756047562561e-05 1013 1.17668844694063 1.17668844694063 1 4.66987851382031 1059 3381 3261 4152 4481 1465 1803 1013 4545 3828 2944 3592 M10495 GO_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WOUND_HEALING.html Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 140/209 Gene Ontology BP GO:0061041 1.47701649452053e-11 4.34972009430633e-10 4170 2590.09090909091 3262 1.34274226775495e-12 107 2.60246495074528 -2.42165889230474 -1 29.3616819500985 4170 1784 107 1488 607 4473 3262 4568 3464 170 4398 3593 M11279 GO_MONOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 63/87 Gene Ontology BP GO:0046365 3.78030595062955e-08 4.02645553947883e-07 4385 2982 3262 3.43664183235213e-09 122 1.7448061351552 1.58899840968665 1 13.3917030323221 4383 1895 2945 3435 122 4375 4369 1739 2739 3538 3262 3594 M11758 GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. 122/154 Gene Ontology BP GO:1903650 1.11420971389879e-07 4.02645553947883e-07 3635 3304.18181818182 3262 1.01291797302631e-08 1168 1.84012917324632 1.97056032028427 1 14.1289494475884 3632 2827 3012 2782 1168 3262 4467 4646 2712 3426 4412 3595 M12475 GO_LONG_TERM_SYNAPTIC_DEPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_DEPRESSION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. 17/24 Gene Ontology BP GO:0060292 1.38214466734223e-06 1.9484906054141e-06 3780 3020.45454545455 3262 1.25649594152003e-07 1189 1.99194311560681 -1.69882607509088 -1 13.6534485235311 3776 3303 2154 2469 3270 4561 3474 1189 3262 3009 2758 3596 M15799 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. 12/33 Gene Ontology BP GO:0006335 0.000293757596167343 0.000307642155067893 1060 2894.36363636364 3262 2.67088025300963e-05 909 1.17668844694063 1.17668844694063 1 4.89484754649557 1060 3382 3262 4153 4482 1466 1804 909 4546 3829 2945 3597 M16766 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. 149/198 Gene Ontology BP GO:0032387 1.65031638389601e-07 4.52287618430271e-07 3185 3274.72727272727 3262 1.5002877342668e-08 1609 1.77506400081193 1.93625966392219 1 13.5173294509421 3181 3434 3105 3262 1609 2496 4070 4057 3233 3595 3980 3598 M15238 GO_COENZYME_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 16/22 Gene Ontology BP GO:0009109 0.000182584064117326 0.000193258337201528 4540 3469.63636363636 3264 1.65999290029965e-05 2180 1.27105855666754 -1.01195755958368 -1 5.60604561415214 4537 2665 3264 2968 4377 4147 4646 2180 3553 2869 2960 3599 M16485 GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin receptor signaling. 61/96 Gene Ontology BP GO:0046626 1.46547797495363e-07 4.35199520158406e-07 4580 3115.27272727273 3264 1.33225279324818e-08 1469 2.0430171644264 2.42363069077349 1 15.6146951087663 4579 2858 1716 2461 1469 4082 3299 4075 3264 2138 4327 3600 M11046 GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION.html Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. 13/17 Gene Ontology BP GO:0032928 3.72881294665865e-06 4.73660022953936e-06 3820 3082.81818181818 3265 3.38983569699504e-07 901 1.78658683930975 1.87267934569392 1 11.4017259573156 3820 2706 2406 3265 3637 4329 3434 2681 901 3211 3521 3601 M14657 GO_CELLULAR_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 158/213 Gene Ontology BP GO:0071478 6.248102908959e-07 1.04464329268366e-06 3295 3214.72727272727 3266 5.68009516677286e-08 2164 1.7154218544434 1.87209598963495 1 12.3054504283678 3293 3649 3266 3260 2741 3021 3903 2164 3935 3525 2605 3602 M12961 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 37/47 Gene Ontology BP GO:1902235 7.03359892993172e-06 8.47199995365579e-06 620 2551.54545454545 3267 6.39420128825832e-07 468 1.8486775547383 -1.71253762804943 -1 11.2369788021063 620 4453 3267 3307 3836 964 468 2282 4056 3768 1046 3603 M15140 GO_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHRONIC_INFLAMMATORY_RESPONSE.html Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. 15/23 Gene Ontology BP GO:0002544 1.373392373879e-06 1.93765758509975e-06 4205 2802.45454545455 3268 1.24853930113308e-07 936 3.50499335115268 -3.76642385559865 -1 24.1128729272809 3733 2205 936 1118 3268 3635 4203 3972 2182 1371 4204 3604 M15489 GO_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 60/79 Gene Ontology BP GO:0046677 4.27043171417982e-05 4.70637583279931e-05 3270 3090.90909090909 3268 3.88228600909995e-06 715 2.4266933046747 2.99336641078477 1 12.5969992068238 3268 4165 2468 2813 4194 3361 4636 715 1917 3817 2646 3605 M15925 GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. 22/30 Gene Ontology BP GO:1902170 5.18311138152684e-06 6.42352711767413e-06 3330 3146.90909090909 3272 4.71193053888068e-07 2136 1.46276522353703 1.81266430897292 1 9.08242501082932 3328 2612 3054 3491 3730 3432 2915 2136 4239 3272 2407 3606 M15072 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. 17/39 Gene Ontology BP GO:0046636 5.69610678381179e-07 9.77646066583411e-07 2670 3371.18181818182 3273 5.17828023510346e-08 2186 1.74110791656686 1.57923099113219 1 12.5518643183468 4437 2669 2930 3273 2668 3839 2822 3787 3842 2186 4630 3607 M16090 GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell. 22/32 Gene Ontology BP GO:1902187 1.25860480988917e-05 1.46407204510358e-05 3275 3326.27272727273 3273 1.14419273667096e-06 2730 1.78784892470515 -1.77942523443003 -1 10.3501584946525 3074 3288 2730 3896 3972 3273 3363 3618 3058 3273 3044 3608 M14341 GO_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_APOPTOTIC_PROCESS.html Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 46/69 Gene Ontology BP GO:0051402 3.01722685731452e-07 6.27027984237805e-07 4630 2799.72727272727 3274 2.74293388283385e-08 141 2.2837567191623 2.66006469585871 1 17.028745331121 4630 1929 1950 994 2181 4411 4145 3274 141 3382 3760 3609 M15903 GO_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 1708/2159 Gene Ontology BP GO:0033554 2.03556411605225e-07 4.99381053281994e-07 3275 3415.27272727273 3274 2.03556430251073e-08 1923 1.66363243942558 1.80146230047738 1 12.5757505797067 3274 3868 4580 4400 1930 1923 3204 3802 2917 4459 3211 3610 M14041 GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. 24/47 Gene Ontology BP GO:1903020 7.61692067268739e-07 1.20754793492383e-06 2060 2889.27272727273 3275 6.92447573622443e-08 536 1.1935429689543 -1.02891988350299 -1 8.43962204035065 2059 3275 3551 3594 2891 1573 536 4624 4221 3927 1531 3611 M12834 GO_FEAR_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEAR_RESPONSE.html The response of an organism to a perceived external threat. 23/47 Gene Ontology BP GO:0042596 0.000159103105490477 0.00016875011393827 3645 2965.09090909091 3276 1.44649648115901e-05 747 2.33932108092869 1.53906426335052 1 10.5708051675584 3644 2979 2304 2499 4366 3382 2467 3276 747 3395 3557 3612 M14426 GO_GROOMING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROOMING_BEHAVIOR.html The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. 9/18 Gene Ontology BP GO:0007625 7.92869778834312e-06 9.48386396122379e-06 3280 3268.81818181818 3278 7.92872607739704e-07 1673 2.08269875039947 -2.45825178731366 -1 12.5490634902246 3278 3095 4493 2755 3880 3538 3085 3639 1673 3032 3489 3613 M12342 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that increases the frequency, rate or extent of cardiac muscle contraction. 10/16 Gene Ontology BP GO:0060452 9.00036467771911e-08 4.02645553947883e-07 4505 3156.63636363636 3279 8.18215004175528e-09 884 3.38529175594267 -3.8240037561645 -1 26.0795292644806 4504 4311 2135 2528 884 4213 3643 3279 2725 2687 3814 3614 M15463 GO_RECIPROCAL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_DNA_RECOMBINATION.html A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules. 30/42 Gene Ontology BP GO:0035825 1.35060071632128e-05 1.56198852625241e-05 310 2110.54545454545 3280 1.22782637077957e-06 43 1.36349590044343 1.38256282591904 1 7.82270742191526 308 3738 3666 3280 3994 111 43 288 3910 3490 388 3615 M16397 GO_RECIPROCAL_MEIOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_MEIOTIC_RECOMBINATION.html The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. 30/42 Gene Ontology BP GO:0007131 1.35060071632128e-05 1.56198852625241e-05 310 2143.81818181818 3281 1.22782637077957e-06 44 1.36349590044343 1.38256282591904 1 7.82270742191526 309 3739 3667 3281 3995 112 44 644 3911 3491 389 3616 M10800 GO_RESPONSE_TO_DIETARY_EXCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DIETARY_EXCESS.html The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. 18/30 Gene Ontology BP GO:0002021 1.42559585693113e-06 2.00220269311818e-06 3190 3043.63636363636 3282 1.29599707337763e-07 1734 2.83906009151076 2.82287488237726 1 19.4631091159778 3188 4029 1757 2012 3282 3886 4088 3774 1734 2331 3399 3617 M14436 GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. 22/59 Gene Ontology BP GO:0046597 4.92111949540788e-05 5.40173838455599e-05 3095 3414.90909090909 3282 4.47384507093077e-06 2494 2.544406832056 -2.48398680077267 -1 13.028885104691 3095 4006 2549 3244 4212 3901 4517 2494 2696 3568 3282 3618 M14552 GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER.html The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. 86/91 Gene Ontology BP GO:0006890 3.07967897232882e-07 6.368776114776e-07 3640 3354.90909090909 3284 2.79970854858093e-08 1967 1.27513938774091 -0.632190171586326 -1 9.45211842187797 3638 3183 3943 4367 2192 3215 3284 2976 1967 4392 3747 3619 M11073 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. 15/18 Gene Ontology BP GO:0002204 2.20528921377503e-05 2.48756623313823e-05 1885 3184.27272727273 3285 2.00482847272427e-06 1615 0.901949086546015 0.907066078412313 1 4.91939948035089 1882 3811 3710 3042 4101 2148 1615 3250 3977 4206 3285 3620 M15480 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. 10/17 Gene Ontology BP GO:0046639 6.39020137882422e-07 1.06381420449621e-06 4435 3622.63636363636 3286 5.80927566813318e-08 2694 2.06896217801025 1.56413752350032 1 14.8430028578086 4432 3087 2813 3286 2753 4392 4217 4340 3234 2694 4601 3621 M14018 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE.html The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. 15/18 Gene Ontology BP GO:0002208 2.20528921377503e-05 2.48756623313823e-05 1885 3183.63636363636 3287 2.00482847272427e-06 1617 0.901949086546015 0.907066078412313 1 4.91939948035089 1884 3813 3712 3044 4103 2150 1617 3222 3979 4209 3287 3622 M15026 GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 1034/1522 Gene Ontology BP GO:0071495 5.50362129121511e-08 4.02645553947883e-07 3780 2616.45454545455 3287 5.50362142751942e-09 345 2.04831032063301 2.23297887862524 1 15.739061837105 3780 1342 4531 439 411 3287 4256 4314 2161 345 3915 3623 M13065 GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT.html Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. 19/19 Gene Ontology BP GO:2000641 5.83201030922063e-05 6.34619830888764e-05 2860 3259.81818181818 3288 5.30196810593029e-06 1816 1.10341174573981 -1.02360882991287 -1 5.4984334182422 2857 4030 3803 2344 4246 3288 1816 2583 3750 4044 3097 3624 M16567 GO_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. 52/56 Gene Ontology BP GO:0051972 3.54715392275012e-06 4.52065384896092e-06 3290 3122.81818181818 3288 3.22469058362794e-07 246 1.99260569303213 2.20241950537568 1 12.7772163028398 3288 4427 2955 2621 3624 2470 2552 4086 246 4100 3982 3625 M13180 GO_POSITIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_T_CELL_SELECTION.html The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. 20/30 Gene Ontology BP GO:0043368 0.000220058962153627 0.000231816697057013 3100 3468.81818181818 3292 2.00073615482371e-05 2069 2.25337303617662 -1.67631538309852 -1 9.80283473927703 3096 4503 2978 4356 4398 3682 2995 2069 3730 3058 3292 3626 M16261 GO_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. 123/170 Gene Ontology BP GO:0030217 1.53190298311386e-07 4.39183276674602e-07 4020 2749.72727272727 3292 1.39263917253024e-08 35 2.0608649824604 -1.69568781527035 -1 15.742141270051 4018 35 1477 1598 1529 4537 3682 4518 3292 1033 4528 3627 M16432 GO_TEMPERATURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TEMPERATURE_HOMEOSTASIS.html A homeostatic process in which an organism modulates its internal body temperature. 22/35 Gene Ontology BP GO:0001659 1.07417056271304e-05 1.26024095519511e-05 995 2556.63636363636 3292 9.76523461351879e-07 208 1.38057241805391 -1.41112768320452 -1 8.07762186385583 991 4009 3292 3517 3942 909 208 1679 4071 3816 1689 3628 M10636 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. 53/89 Gene Ontology BP GO:0032757 1.9989032288128e-07 4.9446553554843e-07 4055 3010.09090909091 3293 1.81718491857423e-08 1741 2.19490917799079 2.11016171237396 1 16.6360673729849 4052 3686 1741 2318 1803 4325 3343 2332 3293 2098 4120 3629 M13466 GO_BASIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASIC_AMINO_ACID_TRANSPORT.html The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/14 Gene Ontology BP GO:0015802 0.00328084752653228 0.0033521702988482 2135 3212.36363636364 3295 0.000298704588667368 2077 1.24781499411202 -1.32123059621824 -1 3.6315828610503 2133 4091 3295 3744 4539 2646 2813 2077 3849 3342 2807 3630 M15861 GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an androgen binding to its receptor. 48/55 Gene Ontology BP GO:0030521 1.4810647509596e-06 2.07073145619441e-06 3490 3031.27272727273 3296 1.34642340729999e-07 1794 1.530437567004 1.73077146628613 1 10.4173691962345 2514 3488 3544 3242 3296 3487 3898 2098 1794 4067 1916 3631 M16322 GO_REGULATION_OF_MYOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of myoblast proliferation. 10/25 Gene Ontology BP GO:2000291 7.82618292958933e-05 8.4392188114436e-05 4500 3140.54545454545 3296 7.11496486239448e-06 1623 2.23027764209792 2.44895391741957 1 10.8849939577839 4498 3078 2064 2262 4286 4159 3296 3406 1935 1623 3939 3632 M12761 GO_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_MODIFICATION.html The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure. 524/725 Gene Ontology BP GO:0016568 9.36739041717055e-07 1.42160690186218e-06 2175 3338.18181818182 3298 9.36739436583302e-08 2124 1.30973066668459 1.42915721589426 1 9.15895048246303 2171 4115 4388 4446 3110 2124 2537 3298 3386 4543 2602 3633 M15733 GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 19/29 Gene Ontology BP GO:1902893 6.20940972003393e-05 6.74582849108519e-05 1485 2951.09090909091 3298 5.64507725909154e-06 1484 1.36748901253513 1.48679996498722 1 6.79514036177812 1484 4033 3298 3541 4252 1839 3395 1545 4292 3258 1525 3634 M16062 GO_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_NUCLEUS.html A process in which a protein is transported to, or maintained in, a location within the nucleus. 186/234 Gene Ontology BP GO:0034504 3.68791279954891e-07 7.15888955206552e-07 2550 3068.72727272727 3298 3.35264856160248e-08 1541 1.6940233065155 1.74079952177874 1 12.4869104616685 2549 4348 3640 3848 2341 1754 3298 3495 3072 3870 1541 3635 M16854 GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY.html Any process that modulates the activity of the enzyme protein phosphatase type 2A. 23/25 Gene Ontology BP GO:0034047 9.91346170770923e-07 1.48271736824079e-06 3405 3053.54545454545 3299 9.01224197712349e-08 630 1.10672836992758 1.51092689886768 1 7.6989310475078 3402 3996 3774 3299 3073 3127 3443 2657 630 4181 2007 3636 M16380 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. 20/23 Gene Ontology BP GO:0016447 5.26001633763497e-06 6.50753948923571e-06 1325 2910.63636363636 3303 4.78184446721546e-07 982 0.907652093796495 0.960156947557846 1 5.59041695916951 1323 3557 3804 3303 3738 1484 982 2593 4090 4227 2916 3637 M11101 GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 11/21 Gene Ontology BP GO:0042136 4.22630096363218e-08 4.02645553947883e-07 4465 3064.18181818182 3304 3.84209185892852e-09 157 2.93773468904369 2.72145937482741 1 22.6180382146151 4462 3077 1275 2880 157 4063 4529 3304 3934 1857 4168 3638 M10572 GO_PROTEIN_HOMOTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTETRAMERIZATION.html The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. 72/87 Gene Ontology BP GO:0051289 3.67039027799533e-07 7.13947601617969e-07 3325 3186.81818181818 3305 3.33671899122583e-08 496 1.69452933420698 2.02059923446723 1 12.4930880825438 3322 3192 3305 2962 2337 2912 4409 4266 496 4158 3696 3639 M15403 GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. 16/17 Gene Ontology BP GO:0033235 1.81713643839695e-06 2.47692955755752e-06 3305 3151 3305 1.65194358118262e-07 2275 1.31958815193516 -0.981942233270682 -1 8.84383129636293 3305 2667 3130 2538 3384 3639 2437 4073 2275 3588 3625 3640 M13916 GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. 19/24 Gene Ontology BP GO:0055098 1.2219131355584e-06 1.75480303078803e-06 3620 3330.72727272727 3307 1.11083074020717e-07 2116 2.5440084033442 3.44552131385806 1 17.605922611377 3617 3307 2125 2992 3199 3395 4443 4527 3245 2116 3672 3641 M13848 GO_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLESION_SYNTHESIS.html The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. 46/55 Gene Ontology BP GO:0019985 1.52777103221952e-06 2.12772182368077e-06 2420 3249.45454545455 3309 1.3888837210618e-07 1783 1.38514027857185 1.4638226022686 1 9.39883400284442 2418 4182 3564 4350 3309 1783 1927 3290 3980 3754 3187 3642 M13599 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate, or extent of mast cell activation. 14/21 Gene Ontology BP GO:0033005 4.12788369768703e-05 4.55251074788759e-05 4340 3288.27272727273 3311 3.75269195604371e-06 973 1.77129997474626 1.64098680246943 1 9.19796075070656 4337 3816 2785 3230 4190 3311 973 3496 2948 2491 4594 3643 M13836 GO_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOTYPE_SWITCHING.html The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 15/18 Gene Ontology BP GO:0045190 2.20528921377503e-05 2.48756623313823e-05 1885 3190.81818181818 3311 2.00482847272427e-06 1616 0.901949086546015 0.907066078412313 1 4.91939948035089 1883 3812 3711 3043 4102 2149 1616 3311 3978 4208 3286 3644 M10606 GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 35/39 Gene Ontology BP GO:0061013 1.53860116750732e-06 2.14088254557762e-06 1415 2974.18181818182 3312 1.39872931231899e-07 1080 1.02978173803948 -1.1206599267907 -1 6.95780860014645 1413 4215 3883 4556 3312 1668 1080 2249 4410 4198 1732 3645 M13425 GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM.html Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. 19/41 Gene Ontology BP GO:0030277 1.5411348614428e-06 2.14376696869757e-06 4640 2682.81818181818 3313 1.40103267366659e-07 623 2.96112588331351 3.31105910272093 1 20.1981030665557 4639 2136 696 915 3313 4140 3508 4085 1121 623 4335 3646 M10594 GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 281/347 Gene Ontology BP GO:0033673 1.9613211052813e-07 4.93246485651519e-07 4345 3143.63636363636 3314 1.78301934557725e-08 1591 1.93024113359854 2.31770626866888 1 14.6201333253567 4343 3125 2517 3538 1769 3314 4549 3665 2656 3513 1591 3647 M12199 GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. 5/26 Gene Ontology BP GO:0002829 2.40118330268299e-06 3.16596937018531e-06 1240 2906.27272727273 3314 2.4011858972435e-07 1238 1.36577646656803 -1.36577646656803 -1 8.98092059264633 1238 3615 4354 3929 3525 1854 1307 2766 3990 3314 2077 3648 M11479 GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. 14/22 Gene Ontology BP GO:0051131 1.30609267322852e-05 1.51552349339958e-05 3315 3091.09090909091 3315 1.18736402480382e-06 746 1.7195262034252 -2.41846412240721 -1 9.91949789539565 3315 3830 3413 3025 3983 2810 2559 3894 746 3975 2452 3649 M12125 GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. 5/10 Gene Ontology BP GO:0031284 1.41156261648005e-06 1.98548998019398e-06 3250 3147.54545454545 3316 1.41156351310991e-07 1289 1.9529136762503 -1.82088080425827 -1 13.3646154440317 3248 1289 4344 2950 3316 3522 3444 2598 4533 1895 3484 3650 M15520 GO_RESPONSE_TO_ACIDIC_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACIDIC_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. 18/28 Gene Ontology BP GO:0010447 0.0050883780374834 0.00518079278083375 3000 3136.81818181818 3316 0.000463653199318354 1021 1.68599187654175 -1.92074125765623 -1 4.55746623003657 3000 4052 3362 3316 4616 2493 1236 3237 4391 3781 1021 3651 M14271 GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION.html The modification of a protein by cis-trans isomerization of a proline residue. 35/41 Gene Ontology BP GO:0000413 7.88527875882759e-05 8.4990044162207e-05 1430 2806.09090909091 3318 7.16869218050977e-06 1427 1.49445410633777 1.57337321484147 1 7.25425688488292 1427 3713 3318 4124 4288 1554 1543 1695 3332 3818 2055 3652 M13898 GO_NEGATIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEATH.html Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 939/1365 Gene Ontology BP GO:0060548 1.00827371312367e-07 4.02645553947883e-07 4120 2892.18181818182 3319 1.00827375887138e-08 703 1.95995438318978 2.05966469127414 1 15.0557002966844 4117 1367 4458 797 1158 3319 4534 4341 2386 703 4634 3653 M13587 GO_GOLGI_TO_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_ENDOSOME_TRANSPORT.html The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. 26/27 Gene Ontology BP GO:0006895 1.2212255595911e-05 1.42343750720876e-05 1430 2667.81818181818 3320 1.11021121699793e-06 749 0.957228412006887 -1.05902011788376 -1 5.50787449228364 1429 3986 3854 3955 3965 1547 749 1285 3320 4156 1100 3654 M16244 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI.html The directed movement of a protein to a specific location in the Golgi apparatus. 18/19 Gene Ontology BP GO:0072600 6.55848624032334e-06 7.9470407490168e-06 920 2505.90909090909 3320 5.9622779928234e-07 162 1.07405694724175 -1.13881602554922 -1 6.52147958982976 919 3320 3631 3783 3815 915 162 1405 4191 3998 1426 3655 M14175 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. 47/51 Gene Ontology BP GO:0014911 3.6557283299569e-07 7.12315909517985e-07 3260 3125.27272727273 3321 3.32338994311589e-08 1389 2.29311844748563 2.49750692297258 1 16.9453720146034 3260 3939 1831 3720 2333 3825 4612 1389 4140 2008 3321 3656 M16642 GO_SYNAPSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSIS.html The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. 19/41 Gene Ontology BP GO:0007129 0.000135756170297918 0.000144316531961667 675 2192.63636363636 3321 1.23422316522935e-05 67 1.56366509111169 1.63642291210544 1 7.16013038456308 674 3321 3371 3474 4381 291 67 710 3827 3838 165 3657 M15423 GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 204/230 Gene Ontology BP GO:0006888 2.15709224631634e-07 5.13521287170422e-07 2990 3198.81818181818 3322 1.96099314347137e-08 1214 1.77666176087352 -1.60247000887794 -1 13.4111024331093 2987 4347 3586 3322 1881 3244 2479 4240 1214 4357 3530 3658 M11917 GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. 19/26 Gene Ontology BP GO:0051156 0.000803517449176536 0.000830652453014535 480 2579.72727272727 3324 7.30737338350143e-05 479 1.08927492773048 -0.998992593917201 -1 3.95529503007023 479 3324 3707 3796 4477 996 480 1235 4216 3833 1834 3659 M13856 GO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING.html The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. 202/235 Gene Ontology BP GO:0006457 9.46206637392536e-07 1.43198214268385e-06 1795 3466.90909090909 3324 8.60188222136827e-08 1794 1.3089577964309 1.42160697701534 1 9.14848564613093 1794 4647 4128 4580 3036 2761 2639 3236 3529 4462 3324 3660 M16226 GO_NEGATIVE_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_SILENCING.html Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 19/26 Gene Ontology BP GO:0060969 0.000122270850121409 0.000130218875169356 3335 3394.09090909091 3324 1.11161496525308e-05 2221 2.00017553081278 -1.90954034627371 -1 9.29567302376945 3334 4032 3084 4173 4343 2899 2221 3324 2846 3259 3820 3661 M16777 GO_RESPONSE_TO_WATER_DEPRIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER_DEPRIVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. 12/17 Gene Ontology BP GO:0009414 5.77757310001457e-05 6.29137552875445e-05 2440 3288.81818181818 3324 5.25247712223742e-06 1927 2.11192316430183 2.39447222083875 1 10.6276940076978 2440 3846 3155 3324 4245 1927 2037 4331 4572 3506 2794 3662 M15880 GO_LIPID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_OXIDATION.html The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. 79/91 Gene Ontology BP GO:0034440 8.52053219163356e-08 4.02645553947883e-07 2690 3124.63636363636 3325 7.74593865602836e-09 812 1.62030420605384 -1.19904923322948 -1 12.4287815522494 2690 2444 3387 3984 812 3556 4155 3149 3273 3596 3325 3663 M12796 GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. 92/121 Gene Ontology BP GO:0009063 2.89552844388479e-06 3.75603396972287e-06 3985 3268.90909090909 3326 2.63230204985412e-07 1846 1.88298265674409 1.6071960193004 1 12.2518708218405 3981 1846 2483 3189 3562 3018 3360 4601 3326 2521 4071 3664 M11123 GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS.html A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism. 1225/1598 Gene Ontology BP GO:0044711 1.19257457020336e-07 4.10546590935448e-07 4370 3447.54545454545 3327 1.1925746342039e-08 1353 1.74080492141879 1.75328075407859 1 13.3429889100466 3673 2761 4278 4460 1353 3252 3327 4367 2782 3300 4370 3665 M11828 GO_PROTEIN_LOCALIZATION_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_LYSOSOME.html A process in which a protein is transported to, or maintained in, a location within a lysosome. 29/30 Gene Ontology BP GO:0061462 1.58709901586679e-06 2.19784872643696e-06 3730 3006.36363636364 3328 1.44281832801354e-07 1113 1.10856370057341 -1.07464406430078 -1 7.48269176571463 1855 3730 3729 3982 3328 1555 1113 2840 4465 4238 2235 3666 M13583 GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 21/25 Gene Ontology BP GO:0090201 1.0751202587191e-06 1.57908287999368e-06 3950 3460.72727272727 3328 9.77382531019165e-08 2909 1.44970237203473 -1.06217701696033 -1 10.0687827254766 3275 4248 3396 3328 3132 3949 3291 3597 2996 3947 2909 3667 M12463 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. 8/12 Gene Ontology BP GO:0032096 9.88319904318623e-05 0.000105837802411842 3865 3058.36363636364 3329 9.88363862000614e-06 789 3.26967760340211 2.17246949363013 1 15.6169616716474 3863 3394 4370 2501 4328 3137 3293 789 969 3329 3669 3668 M14424 GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. 27/29 Gene Ontology BP GO:0031442 5.00772880355575e-07 8.86381301052373e-07 4210 3493.54545454545 3329 4.55248176675959e-08 2246 1.2970816466423 -0.885114048759515 -1 9.39133168715246 4210 2590 3329 4501 2580 3283 2246 4648 3816 3906 3320 3669 M14915 GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. 108/123 Gene Ontology BP GO:1904029 3.14040607335017e-06 4.04773115216021e-06 2540 3284.45454545455 3329 2.85491868741338e-07 2538 1.75700730956123 1.8766265705373 1 11.3562858406707 2538 3904 3278 3329 3585 2726 2648 3427 3283 4048 3363 3670 M13920 GO_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that modulates the frequency, rate or extent of protein acetylation. 75/101 Gene Ontology BP GO:1901983 2.09160650166946e-06 2.80629903467936e-06 2605 2981.18181818182 3330 1.90146226384149e-07 1917 1.59819269767033 1.49946822002239 1 10.6279665049468 2603 2450 3330 2345 3438 1917 2005 3509 3526 3541 4129 3671 M10822 GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. 44/53 Gene Ontology BP GO:0043496 6.42988030099964e-05 6.97069735334374e-05 1520 2836.81818181818 3332 5.84551657550557e-06 843 1.73871214253399 -1.29527963116444 -1 8.63777535990296 1520 3942 3332 3598 4262 1615 843 3454 3775 3208 1656 3672 M14423 GO_I_KAPPAB_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_PHOSPHORYLATION.html The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 32/54 Gene Ontology BP GO:0007252 6.00446988096846e-07 1.01484919564643e-06 3905 3016.63636363636 3332 5.45861047251976e-08 740 2.1464717100485 2.02056705027017 1 15.4560473634198 3902 3720 2396 2325 2711 3332 4235 1932 740 3824 4066 3673 M15702 GO_NEGATIVE_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APPETITE.html Any process that reduces appetite. 8/12 Gene Ontology BP GO:0032099 9.88319904318623e-05 0.000105837802411842 3865 3079.45454545455 3332 9.88363862000614e-06 812 3.26967760340211 2.17246949363013 1 15.6169616716474 3864 3395 4568 2502 4329 3138 3294 812 970 3332 3670 3674 M11117 GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. 14/18 Gene Ontology BP GO:0045820 0.000838916623511328 0.000866669415896583 2960 3194.27272727273 3333 7.6294244990632e-05 1498 1.15646448229731 1.46623624361624 1 4.17983710751789 2959 3831 3510 3333 4478 2106 1705 3092 4461 4164 1498 3675 M14564 GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 14/18 Gene Ontology BP GO:0051198 0.000838916623511328 0.000866669415896583 2960 3190.09090909091 3334 7.6294244990632e-05 1499 1.15646448229731 1.46623624361624 1 4.17983710751789 2960 3832 3511 3334 4479 2107 1706 3032 4462 4169 1499 3676 M14518 GO_DNA_METHYLATION_OR_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_OR_DEMETHYLATION.html The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. 47/65 Gene Ontology BP GO:0044728 1.62274345289286e-06 2.24387081316805e-06 2820 3473.72727272727 3335 1.47522240895179e-07 2372 1.25636264218414 1.47002346050803 1 8.48037129301537 2820 4179 3864 4390 3335 2826 3078 3103 3851 4393 2372 3677 M15248 GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 14/18 Gene Ontology BP GO:0051195 0.000838916623511328 0.000866669415896583 2965 3196 3335 7.6294244990632e-05 1500 1.15646448229731 1.46623624361624 1 4.17983710751789 2961 3833 3512 3335 4480 2108 1707 3087 4463 4170 1500 3678 M15348 GO_REGULATION_OF_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPIRATION.html Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. 28/34 Gene Ontology BP GO:0043457 3.89747766319461e-06 4.93065893606431e-06 875 2500 3338 3.54316778900742e-07 171 1.60576050579487 1.49800156269438 1 10.2034339657119 872 3522 3338 4195 3652 350 171 1759 4320 3788 1533 3679 M10931 GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 50/61 Gene Ontology BP GO:0043647 1.64335553725533e-06 2.26900098363473e-06 3455 3155.36363636364 3339 1.4939606952818e-07 1996 1.69186108752785 -1.67450895886891 -1 11.4457511732524 3454 2493 3227 3457 3339 4166 3955 1996 2160 3789 2673 3680 M15308 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of magnesium ion across a membrane. 17/18 Gene Ontology BP GO:1903830 2.79642357197268e-05 3.12557263521232e-05 3015 3270.09090909091 3339 2.54223556180969e-06 1381 1.85282369391242 -1.7623028386939 -1 9.99200419045412 3765 3011 2688 3872 4140 4553 4227 1980 1381 3015 3339 3681 M11936 GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 87/142 Gene Ontology BP GO:0019217 9.80104672664217e-06 1.15805663837141e-05 3915 3328.27272727273 3340 8.91008217344166e-07 2142 1.65313467066522 -1.3977326375324 -1 9.76611080612956 3140 3912 3502 3340 3911 2984 3333 3312 3622 3413 2142 3682 M10560 GO_REGULATION_OF_PROSTAGLANDIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROSTAGLANDIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. 13/18 Gene Ontology BP GO:0032306 3.50095727986128e-06 4.47130969010667e-06 3145 3171.36363636364 3341 3.18269350100166e-07 1606 1.65824052894882 -1.92743266753389 -1 10.6254438518834 3144 3583 2449 3758 3617 3341 1606 2065 4584 3210 3528 3683 M10860 GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. 35/40 Gene Ontology BP GO:0035872 1.64965409409047e-06 2.27702180356065e-06 245 2072.36363636364 3341 1.49968666461178e-07 65 1.43903383538297 -1.46636993818239 -1 9.71727549226936 243 3502 3473 3555 3341 374 65 392 3393 3414 1044 3684 M14409 GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of a different species. 775/1069 Gene Ontology BP GO:0044419 1.28113952091097e-07 4.17034908558357e-07 2695 3387.09090909091 3342 1.28113959477031e-08 1430 1.44679052985345 -1.37125795446597 -1 11.060111211406 2693 4337 4492 4086 1430 2987 2629 3737 3342 4550 2975 3685 M14673 GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 54/68 Gene Ontology BP GO:1901028 1.96690320750011e-06 2.6596921315019e-06 1475 2886.36363636364 3342 1.78809542364187e-07 1474 1.51771423754518 1.76306884183777 1 10.1303733012665 1474 3478 3421 3342 3410 1609 2189 2523 3498 3935 2871 3686 M10140 GO_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 106/151 Gene Ontology BP GO:0016052 1.7774481304227e-07 4.69379463726267e-07 3345 2933 3343 1.61586206729842e-08 937 1.62554634812372 -1.90565610663371 -1 12.3383919246673 3343 3166 3458 3465 1682 3636 3593 937 2465 4002 2516 3687 M16124 GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. 775/1069 Gene Ontology BP GO:0044403 1.28113952091097e-07 4.17034908558357e-07 2695 3384 3343 1.28113959477031e-08 1431 1.44679052985345 -1.37125795446597 -1 11.060111211406 2694 4338 4595 4087 1431 2988 2630 3591 3343 4551 2976 3688 M13223 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 33/44 Gene Ontology BP GO:0030947 6.76945298766502e-06 8.17924298925093e-06 1570 2998.27272727273 3344 6.15406710684058e-07 1567 1.80263623966951 1.77939836303174 1 10.9878540367345 1567 3714 2391 3721 3823 1598 2287 3858 4313 2365 3344 3689 M15235 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 18/22 Gene Ontology BP GO:0030812 0.000434834386705697 0.000452029580281861 3005 3204.45454545455 3344 3.95382142162836e-05 492 1.02842634004215 1.20922161038319 1 4.05726566459461 3001 3799 3651 3344 4453 2061 3029 2684 4442 4293 492 3690 M16359 GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosyl compound. 112/135 Gene Ontology BP GO:1901659 6.29361107250817e-07 1.05111889161452e-06 2525 3382.18181818182 3344 5.72146624812959e-08 2524 1.18945965856123 1.26859349407851 1 8.49707148812438 2524 3444 4028 4212 2744 3193 3344 3077 2716 4370 3552 3691 M15163 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION.html The process in which immune receptor genes are diversified through somatic mutation. 11/14 Gene Ontology BP GO:0002566 2.48724130076392e-05 2.7940931367587e-05 1665 2687.36363636364 3346 2.26115401915401e-06 373 1.1320484903742 1.240334344185 1 6.1315775811617 1665 4092 3406 3742 4338 1503 1590 373 4038 3346 1468 3692 M11321 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION.html The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. 23/23 Gene Ontology BP GO:0006295 0.00361359282990834 0.00368971855114406 1185 2850.36363636364 3347 0.000329049272142226 414 0.916323860594321 0.954003170590766 1 2.59329942002833 1181 4023 3994 3347 4588 941 414 1737 4368 4384 2377 3693 M11433 GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. 71/79 Gene Ontology BP GO:0032922 1.67359077039064e-06 2.30527467573347e-06 2650 3124 3347 1.52144731230102e-07 2027 1.68950197185188 -1.53608470277165 -1 11.4155736613346 2647 3463 3344 3715 3347 2583 2027 3879 2466 3486 3407 3694 M16455 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION.html The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 23/23 Gene Ontology BP GO:0006293 0.00434211411144832 0.00442969896087898 1185 2857.09090909091 3348 0.000395518895114878 415 0.916323860594321 0.954003170590766 1 2.50532945408931 1182 4024 3995 3348 4589 942 415 1801 4369 4385 2378 3695 M12579 GO_MAINTENANCE_OF_LOCATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION_IN_CELL.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. 112/136 Gene Ontology BP GO:0051651 4.85054196759023e-07 8.65729642316737e-07 3240 3287.45454545455 3349 4.40958457912189e-08 2560 1.61349348037059 1.79642218152663 1 11.7273599285226 3238 3661 3461 2596 2560 3349 4417 3376 3312 3527 2665 3696 M14606 GO_APOPTOTIC_DNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_DNA_FRAGMENTATION.html The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. 15/18 Gene Ontology BP GO:0006309 1.60433348431974e-05 1.84092816338835e-05 3350 3128.81818181818 3349 1.45849562174607e-06 1559 1.51245176734852 -1.94741596692592 -1 8.55802443419253 2975 3349 3348 3718 4029 4121 4446 1600 1559 3475 1797 3697 M15946 GO_RESPONSE_TO_ETHER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. 11/17 Gene Ontology BP GO:0045472 5.08916523276671e-05 5.57436107063642e-05 3905 3127.90909090909 3349 4.6266208745878e-06 151 2.46888946684623 2.6510508040852 1 12.5983436687145 3901 2731 2344 1819 4221 3889 4283 3308 151 3349 4411 3698 M14941 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 40/70 Gene Ontology BP GO:0009948 1.0510529816016e-07 4.02645553947883e-07 4060 2934.27272727273 3351 9.55502756196186e-09 242 2.14062265019208 -1.86990787427903 -1 16.4530228628463 4056 2522 2083 242 1078 4239 4133 3851 3351 2564 4158 3699 M12575 GO_REGULATION_OF_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_SILENCING.html Any process that affects the rate, extent or location of chromatin silencing. 26/33 Gene Ontology BP GO:0031935 0.000410675700701674 0.000427775696298386 2430 3029.09090909091 3354 3.73411256266123e-05 1421 1.81545609966326 2.00696154741702 1 7.29357033069382 2428 3992 3354 3071 4445 3451 3510 1421 2433 3659 1556 3700 M11794 GO_COPPER_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_TRANSPORT.html The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 17/20 Gene Ontology BP GO:0006825 5.1357838327112e-06 6.36928088949873e-06 1245 2739.90909090909 3355 4.66890529269686e-07 735 1.4470530137637 -1.49923200650999 -1 8.99020650022985 1242 4048 3355 3493 3727 1226 735 2473 3973 3373 2494 3701 M10940 GO_CELLULAR_RESPONSE_TO_SUPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_SUPEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. 14/21 Gene Ontology BP GO:0071451 1.4838814173887e-05 1.71053049907562e-05 1990 3096.27272727273 3356 1.34899220558003e-06 1281 1.29930377816977 -1.37578896681065 -1 7.38757904235772 1986 4572 3466 4243 4009 2242 1281 1840 4608 3356 2456 3702 M11054 GO_BARBED_END_ACTIN_FILAMENT_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BARBED_END_ACTIN_FILAMENT_CAPPING.html The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. 14/19 Gene Ontology BP GO:0051016 7.70368224959292e-05 8.30904810091698e-05 3360 3159.09090909091 3357 7.00359274603383e-06 1333 2.1532452855063 -2.91522468586043 -1 10.5230575736687 4208 3358 2684 2510 4284 4129 4596 1783 1333 3357 2508 3703 M11870 GO_GABAERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABAERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. 6/21 Gene Ontology BP GO:0097154 5.3217729637914e-07 9.28118800619242e-07 4365 3308.81818181818 3357 5.32177423824885e-08 2075 2.91292932792576 3.7712280127747 1 21.1485051470692 4362 2311 4330 2280 2691 4341 4053 3357 2075 2246 4351 3704 M11209 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html The directed movement of a protein to a specific location in the endoplasmic reticulum. 126/216 Gene Ontology BP GO:0072599 9.90150157285839e-05 0.000106009403632099 270 2885.72727272727 3359 9.00177021462863e-06 269 0.670293536593352 -0.547971461147171 -1 3.11910162506882 269 4384 4192 3359 4315 1105 646 1683 4607 4604 2579 3705 M12040 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. 152/246 Gene Ontology BP GO:0070972 4.02907140753608e-06 5.08193799383719e-06 600 3006.36363636364 3360 3.66279889670967e-07 599 0.833924122616449 -0.603639320829224 -1 5.23625308625825 599 4372 4196 3360 3663 1347 714 2869 4497 4590 2863 3706 M12902 GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 14/15 Gene Ontology BP GO:1902895 0.000149751183529083 0.000158903593377611 1800 3143.72727272727 3361 1.36146707156298e-05 1784 1.06333190134748 1.12102746755438 1 4.78234919520395 1798 4069 3367 3306 4363 2189 3719 1784 4517 3361 2108 3707 M14496 GO_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 31/38 Gene Ontology BP GO:0001935 3.50170911471066e-06 4.47130969010667e-06 4500 3172.09090909091 3361 3.18337698940392e-07 1030 2.05257979477931 2.08173569947729 1 13.1767203143745 4496 2544 1957 2234 3618 3927 4381 2772 3361 1030 4573 3708 M15478 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY.html The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. 139/229 Gene Ontology BP GO:0000184 0.000119327895198248 0.000127171941446965 490 2979.36363636364 3361 1.08485789117387e-05 440 0.667606163353194 -0.559679794108003 -1 3.04236102502915 487 4379 4210 3361 4340 1331 440 2188 4592 4640 2805 3709 M12217 GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. 412/567 Gene Ontology BP GO:0044283 1.2460306727886e-07 4.14338946095474e-07 3700 2827.81818181818 3362 1.13275522123727e-08 868 1.92162320735454 -1.95102356288812 -1 14.7303457131546 3698 1502 1230 3362 1287 4373 4324 3937 2790 868 3735 3710 M11161 GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL.html Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 13/21 Gene Ontology BP GO:0045760 3.76191884986108e-07 7.2481194237696e-07 4410 3040.09090909091 3363 3.41992681194134e-08 49 2.51890783595843 2.6147582532192 1 18.6010088443229 4408 3363 1782 3702 2923 4312 3739 49 2287 2777 4099 3711 M12067 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 13/15 Gene Ontology BP GO:0040037 1.16916835630033e-06 1.69000943207998e-06 4350 2848.72727272727 3364 1.06288088876711e-07 1138 2.56195609560889 -2.33030362280698 -1 17.7814826628049 4346 1138 1578 1151 3182 4254 3838 3480 3364 1377 3628 3712 M14253 GO_REGULATION_OF_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ISOTYPE_SWITCHING.html Any process that modulates the frequency, rate or extent of isotype switching. 18/29 Gene Ontology BP GO:0045191 1.83593411731506e-05 2.08916640935852e-05 3305 3452.45454545455 3364 1.66904494422635e-06 1711 1.49993079537344 -1.2833369060686 -1 8.38666876091569 3304 4264 3364 3733 4064 3199 1711 4404 3241 3454 3239 3713 M15152 GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 14/21 Gene Ontology BP GO:0071450 1.4838814173887e-05 1.71053049907562e-05 1990 3085.36363636364 3364 1.34899220558003e-06 1282 1.29930377816977 -1.37578896681065 -1 7.38757904235772 1987 4573 3467 4244 4010 2243 1282 1703 4609 3364 2457 3714 M14974 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. 11/20 Gene Ontology BP GO:0032691 1.28091339677646e-05 1.48816230591782e-05 4395 3457.72727272727 3365 1.16447350431126e-06 2087 1.47190206479199 -1.99919966194444 -1 8.49027713228813 4394 2730 2799 2775 3978 4574 4416 3365 2087 3345 3572 3715 M15982 GO_CHROMATIN_SILENCING_AT_RDNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING_AT_RDNA.html Repression of transcription of ribosomal DNA by altering the structure of chromatin. 18/40 Gene Ontology BP GO:0000183 4.74465546415848e-05 5.21295912036113e-05 2665 2931.45454545455 3365 4.31341617582672e-06 497 1.30426066847171 1.52473006222506 1 6.65278227738623 2665 4040 3365 4205 4500 1804 1374 497 4227 4295 1274 3716 M15332 GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 308/352 Gene Ontology BP GO:0010498 1.56531530049225e-07 4.41807401483567e-07 3370 3443.81818181818 3368 1.42301401078684e-08 1559 1.25717624063733 1.52610143938447 1 9.55899267373929 3368 4630 4176 4084 1559 2958 3136 3265 2698 4525 3483 3717 M11586 GO_ACETYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. 22/26 Gene Ontology BP GO:0006084 0.000411495472526746 0.000428533669128681 765 2695.27272727273 3369 3.74156781998562e-05 712 1.49984790671992 -1.54360618907009 -1 6.00632535924641 764 4249 3369 4169 4446 1155 712 1148 3752 3812 2072 3718 M13431 GO_METHIONINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 13/16 Gene Ontology BP GO:0009086 2.70211492855976e-06 3.52281893039747e-06 1585 3164.90909090909 3369 2.4564711339955e-07 1581 1.31003641279932 1.4809069333907 1 8.536701362195 1581 4079 3549 3951 3539 2861 3280 2025 3369 3609 2971 3719 M15144 GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 149/237 Gene Ontology BP GO:0070374 2.37867278312758e-07 5.43346316145932e-07 4035 2583.81818181818 3370 2.16243003664843e-08 334 2.27319792109154 -2.31824719079503 -1 17.1205662790032 4035 2386 468 793 1974 4042 3791 3370 3588 334 3641 3720 M12282 GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 172/233 Gene Ontology BP GO:0010822 2.80188244243356e-07 5.95298733682208e-07 2575 3319.63636363636 3371 2.54716618116053e-08 2096 1.28877305933259 1.32164946779272 1 9.59998128926326 2575 4124 4066 4597 2130 2096 2510 2867 3759 4421 3371 3721 M13860 GO_REGULATION_OF_MRNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_POLYADENYLATION.html Any process that modulates the frequency, rate or extent of mRNA polyadenylation. 13/13 Gene Ontology BP GO:1900363 2.93752074140989e-05 3.2785521731303e-05 3805 3325.90909090909 3371 2.67050905908922e-06 2142 0.938982845127287 -0.994832430896735 -1 4.98944866323828 2498 3371 3805 3802 4147 2873 2142 3318 4122 4134 2373 3722 M11887 GO_PHAGOLYSOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOLYSOSOME_ASSEMBLY.html The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. 15/19 Gene Ontology BP GO:0001845 2.99228888627352e-07 6.23237251021965e-07 3270 3230.45454545455 3372 2.72026299387653e-08 1111 1.24880849793165 1.3191787283167 1 9.26901240032197 3266 1111 2989 3455 2175 3982 4625 4297 3372 3468 2795 3723 M12320 GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). 41/43 Gene Ontology BP GO:0006891 1.79401944309487e-06 2.4530039578961e-06 405 2527.18181818182 3372 1.63092809641246e-07 254 0.819675888676301 -0.797046352090337 -1 5.45861197926277 402 4447 4088 4576 3372 254 501 963 4306 4458 432 3724 M16069 GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that modulates the frequency, rate or extent of the viral entry into the host cell. 30/69 Gene Ontology BP GO:0046596 3.85796837998021e-06 4.88732013940864e-06 3185 3143.63636363636 3373 3.50725013219547e-07 1189 2.59295620721604 -2.42839521469437 -1 16.5516613019387 3182 3726 1990 3181 3647 3833 3931 3916 1189 2612 3373 3725 M15885 GO_NAD_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. 11/16 Gene Ontology BP GO:0009435 7.57303087328367e-06 9.08646535672742e-06 2290 3444.54545454545 3374 6.88459721995746e-07 2286 1.89560577790789 -2.01607610233204 -1 11.4551263556954 2286 3374 2887 3910 3853 2989 4276 4525 3900 3348 2542 3726 M11434 GO_RETINOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. 27/44 Gene Ontology BP GO:0042572 1.09352141838205e-06 1.59653440845048e-06 3805 3326.54545454545 3376 9.94110874475384e-08 1897 2.39790879714579 1.98566763184863 1 16.7079673515385 3801 3742 1897 3884 3154 3376 3186 2234 3899 2913 4506 3727 M15862 GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 13/16 Gene Ontology BP GO:0032785 0.00219127766911903 0.00224532371601208 1725 3307.27272727273 3376 0.00019940575521896 1722 0.667947173368534 -0.712815185478165 -1 2.03671490726834 1722 3376 3852 4372 4523 1934 2030 2710 4583 4643 2635 3728 M16084 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. 22/42 Gene Ontology BP GO:0032733 1.13991986689298e-06 1.65650160123314e-06 3545 3413.81818181818 3376 1.03629132503421e-07 2351 2.04437811461402 -2.3046011055236 -1 14.1898906457137 3545 4005 2351 3789 3169 4399 4513 3336 3376 2585 2484 3729 M12250 GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 232/301 Gene Ontology BP GO:0010821 2.48969684812968e-07 5.59143257290898e-07 2810 3306.36363636364 3377 2.26336102716712e-08 2009 1.37548218230919 1.45002258330076 1 10.2980656437538 2808 4345 4068 4289 2009 2250 2721 2655 3412 4436 3377 3730 M11541 GO_MAGNESIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSPORT.html The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/15 Gene Ontology BP GO:0015693 9.73773464220697e-07 1.46160255774803e-06 4625 3004.27272727273 3378 8.85248995669786e-08 905 1.9439381652478 2.07656208758829 1 13.6154914771357 4622 1109 2178 3378 3063 3785 3442 3891 905 2486 4188 3731 M14613 GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. 8/13 Gene Ontology BP GO:0048484 1.64214297635031e-06 2.2679997830092e-06 3480 2813.27272727273 3378 1.64214418983667e-07 680 2.06087188205833 -1.69007124436532 -1 13.9651108095354 3476 1258 4503 2073 3378 4586 4150 1556 3744 680 1542 3732 M15483 GO_CELL_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_RECOGNITION.html Cell recognition between cells. May involve the formation of specialized cell junctions. 60/135 Gene Ontology BP GO:0009988 3.07330483741987e-06 3.96234065073834e-06 4630 2933 3380 2.79391739154744e-07 938 2.42790401160587 -2.10698509529471 -1 15.759079857408 4628 2859 1545 1187 3584 3441 3380 3745 938 2500 4456 3733 M13452 GO_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that modulates the amount of sodium excreted in urine over a unit of time. 13/27 Gene Ontology BP GO:0035813 1.81119148949632e-06 2.4707343564074e-06 3990 3089.27272727273 3381 1.64653907326872e-07 1338 2.90895643991086 2.088326528701 1 19.6235521902077 3987 3055 1338 3879 3381 4028 2363 1974 3843 1813 4321 3734 M15563 GO_CAMP_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 11/14 Gene Ontology BP GO:0006198 4.20259525172714e-07 7.87859617497438e-07 4275 3284.54545454545 3381 3.82054186776069e-08 2272 1.8735587586858 1.60673085182732 1 13.726938286142 4275 2272 2361 2904 2434 4523 4014 3533 3381 2387 4046 3735 M11009 GO_SERTOLI_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. 17/21 Gene Ontology BP GO:0060009 1.8112346635946e-06 2.4707343564074e-06 3940 3377.54545454545 3382 1.64657832251359e-07 2548 1.9536525367585 2.12979539884679 1 13.145348622088 3937 3325 2548 4500 3382 3565 3052 3579 3277 2592 3396 3736 M12980 GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a symbiont organism effects a change in the structure or processes of its host organism. 52/81 Gene Ontology BP GO:0044003 5.38154930427454e-07 9.33992872539704e-07 4480 3154 3383 4.89231874607945e-08 1295 1.73803873490989 -1.57683549560019 -1 12.5712559812253 4476 3483 3383 2339 2633 4485 2475 1857 1295 3999 4269 3737 M13386 GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 125/164 Gene Ontology BP GO:0016051 2.99128381919376e-07 6.23237251021965e-07 3745 3235.36363636364 3384 2.71934929628278e-08 2174 1.77772858198514 -1.62090033901484 -1 13.2384146536959 3744 2826 2802 3671 2174 4186 3495 3384 2188 3183 3936 3738 M13060 GO_SUBSTANTIA_NIGRA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTANTIA_NIGRA_DEVELOPMENT.html The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). 78/111 Gene Ontology BP GO:0021762 1.81792997157783e-06 2.47696285732112e-06 3635 3052.27272727273 3387 1.65266497617538e-07 1889 2.0402029849831 2.3846480320596 1 13.7295753148196 3634 4153 2836 2247 3387 3444 3574 1889 2266 4079 2066 3739 M13383 GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. 20/24 Gene Ontology BP GO:0031954 4.60193605647417e-05 5.06212966212159e-05 1365 2988.36363636364 3387 4.18366574735537e-06 1099 1.71071872827932 1.74678343106633 1 8.78451327771928 1364 4008 3076 3937 4202 1677 1099 3816 4004 3387 2302 3740 M16175 GO_IMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. 10/11 Gene Ontology BP GO:0006188 1.4840772887961e-05 1.71053049907562e-05 850 2550.72727272727 3387 1.34917027289811e-06 216 0.797986910782795 0.797986910782795 1 4.49746779386428 847 3387 3505 4182 4011 673 216 956 4481 4213 1587 3741 M10178 GO_ETHER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHER_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. 10/13 Gene Ontology BP GO:0018904 0.00469537705139157 0.00478693896146471 2155 3329 3388 0.000427766205740073 2121 1.6141709359444 -1.6141709359444 -1 4.42597296143153 2154 3609 3575 2815 4547 2774 2121 3351 4322 3963 3388 3742 M11985 GO_SPERM_CAPACITATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_CAPACITATION.html A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. 13/27 Gene Ontology BP GO:0048240 1.32051782149637e-05 1.52997246599169e-05 3200 3224.54545454545 3389 1.2004779525255e-06 1351 1.18552190399431 -1.49198419687713 -1 6.80108411863119 3197 3820 3389 4145 3988 2678 1351 4604 4114 2781 1403 3743 M15934 GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION.html The directed movement of the mitochondrion to a specific location. 20/23 Gene Ontology BP GO:0051654 2.39298118932654e-06 3.15694399601259e-06 3695 3375.09090909091 3389 2.17543981110995e-07 2439 2.04345966692921 2.81393243766228 1 13.4913047997484 3693 4027 2747 3797 3493 4316 3168 3023 3034 3389 2439 3744 M10886 GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 172/209 Gene Ontology BP GO:0031330 2.10462080111272e-07 5.07398994174999e-07 3395 3344.81818181818 3391 1.91329182040947e-08 1857 1.49180314408169 -1.2864820711804 -1 11.2537419120004 3391 2805 3612 3297 1857 3779 4344 4339 2547 3891 2931 3745 M12905 GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT.html The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 17/35 Gene Ontology BP GO:0007603 1.89246127981946e-06 2.56873463681445e-06 3715 2944.45454545455 3393 1.72042082521356e-07 518 2.29887548481822 2.6235246537196 1 15.4394420864715 3711 2198 2697 1587 3397 3712 4463 3393 518 3010 3703 3746 M14580 GO_REGULATION_OF_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_FUSION.html Any process that modulates the frequency, rate or extent of myoblast fusion. 15/24 Gene Ontology BP GO:1901739 3.76843649997668e-05 4.16992509735826e-05 2370 3484.18181818182 3394 3.42591004731029e-06 2369 1.78176720644787 -1.87885590210416 -1 9.33507244411547 2369 3806 2929 4326 4174 3394 3061 3273 4178 3474 3342 3747 M14571 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 67/72 Gene Ontology BP GO:0051881 2.49909010583195e-07 5.59858751200582e-07 3415 3237.09090909091 3396 2.27190035428741e-08 2016 1.73137288885196 1.84368793207639 1 12.9880517857888 3413 3196 3030 3564 2016 2387 3396 4196 2664 3576 4170 3748 M14652 GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. 12/12 Gene Ontology BP GO:0051292 6.40915534846096e-05 6.94984848202956e-05 2415 3377.72727272727 3398 5.82667460995508e-06 2411 1.22460789777405 1.2057394916116 1 6.05523280567038 2411 3840 3598 3775 4261 3270 2525 2826 4168 3083 3398 3749 M13986 GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. 52/88 Gene Ontology BP GO:0043471 7.92079201316006e-08 4.02645553947883e-07 4460 3248.45454545455 3399 7.20072027121557e-09 713 1.54408718043454 1.76776095642673 1 11.8393046530094 4456 3479 3334 3083 713 3459 3205 3399 2902 3858 3845 3750 M16666 GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 23/39 Gene Ontology BP GO:0035458 0.000113349774946427 0.000120939349421171 810 2878.45454545455 3399 1.03050559496057e-05 587 1.90268110832482 -2.2714431362337 -1 8.91143594088947 807 4251 2914 3998 4333 1738 587 3598 4116 3399 1922 3751 M11409 GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. 1731/2411 Gene Ontology BP GO:0009891 1.29109052677566e-07 4.18345697847296e-07 3380 3460.09090909091 3400 1.29109060178683e-08 1437 1.80097033261016 1.89664779709977 1 13.7899042841637 3377 3400 4297 4329 1437 3071 4138 4017 3055 3392 3548 3752 M14010 GO_RESPONSE_TO_CARBOHYDRATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CARBOHYDRATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 192/256 Gene Ontology BP GO:0009743 1.87226006808131e-07 4.82197350765291e-07 4385 3487 3400 1.70205475219616e-08 1724 1.85026064567447 1.91928067185362 1 14.0320919599402 4381 4646 2954 3054 1724 4471 3268 3685 3185 3400 3589 3753 M10507 GO_POSITIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DEATH.html Any process that activates or increases the frequency, rate or extent of neuron death. 94/112 Gene Ontology BP GO:1901216 1.07389819592738e-07 4.02645553947883e-07 4145 3239.90909090909 3401 9.76271134861975e-09 1106 1.78734466149619 -1.34152344171066 -1 13.720704044917 3989 4144 3009 2153 1106 3997 3150 3401 2539 4010 4141 3754 M13384 GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. 75/93 Gene Ontology BP GO:0046823 1.42209742922112e-07 4.2854237685504e-07 4365 3237.72727272727 3401 1.29281592831512e-08 1163 2.02073428197969 2.07942987846161 1 15.4596258400639 4364 3458 2703 3213 1440 4236 3947 4500 1163 3401 3190 3755 M13094 GO_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. 1464/1884 Gene Ontology BP GO:0065003 1.42360905075632e-07 4.2854237685504e-07 2915 3240.27272727273 3402 1.42360914195615e-08 1561 1.71732142149487 1.81085282152485 1 13.1229069252333 2914 3402 4407 4117 1561 2444 2860 3732 2356 4214 3636 3756 M10329 GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. 78/108 Gene Ontology BP GO:0009132 1.39484621709395e-07 4.25515040482715e-07 3410 3078.18181818182 3406 1.26804209593649e-08 1422 1.50898301831362 1.54377577186239 1 11.5240179647886 2633 3459 3408 3734 1422 2589 2060 4356 3155 3406 3638 3757 M12943 GO_PLATELET_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_MORPHOGENESIS.html Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. 23/38 Gene Ontology BP GO:0036344 1.9475064405495e-06 2.63499490197058e-06 3515 3040.72727272727 3408 1.7704619677665e-07 326 2.1936600758575 -1.34358184132329 -1 14.6987506321116 3512 3744 2255 1584 3408 3714 4103 3300 326 3097 4405 3758 M12360 GO_ENAMEL_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENAMEL_MINERALIZATION.html The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. 10/13 Gene Ontology BP GO:0070166 2.08036814278613e-06 2.79525064059598e-06 3710 2800.27272727273 3409 1.89124555457307e-07 136 2.77173944785486 -3.44673164569881 -1 18.5133857902748 3710 2734 1815 1476 3434 3999 3409 4019 136 2150 3921 3759 M10644 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process. 220/244 Gene Ontology BP GO:1903364 1.69968516970329e-07 4.57756928916714e-07 3415 3354.63636363636 3411 1.54516845547117e-08 1644 1.42632251158144 1.58754123588266 1 10.8323877067587 3411 3423 3971 3110 1644 3063 3197 4384 2209 4407 4082 3760 M16551 GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 46/71 Gene Ontology BP GO:0006636 2.91159722721038e-08 3.72894192114222e-07 4070 2906.81818181818 3411 2.64690660522184e-09 58 2.17422243038408 -2.4188729588562 -1 16.8005502828175 4067 1934 1451 3411 58 4609 3303 3680 3833 1220 4409 3761 M16724 GO_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_SELECTION.html The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. 29/47 Gene Ontology BP GO:0045058 1.98324219107357e-06 2.67945003341037e-06 4645 3159 3412 1.80294907174231e-07 1464 2.30069852827089 -1.56793400789625 -1 15.4007749384785 4641 3512 2307 3028 3412 3887 4302 1464 2449 1878 3869 3762 M15094 GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. 17/26 Gene Ontology BP GO:0043567 2.49210489728484e-05 2.7988810251186e-05 3415 2952.72727272727 3415 2.26557557061148e-06 882 3.75729890686513 4.61496746403141 1 20.5862513839722 3415 4039 1300 4106 4119 4253 4114 882 1019 2187 3046 3763 M15633 GO_FOREBRAIN_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. 6/14 Gene Ontology BP GO:0021877 9.14238004894679e-06 1.08463779622003e-05 3055 3394.54545454545 3415 9.14241766156541e-07 1737 2.31215843537079 2.91040860197394 1 13.7799661845624 3053 3614 4567 2998 3919 3415 2960 4366 1737 3537 3174 3764 M15424 GO_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 246/358 Gene Ontology BP GO:0009636 2.63645239449897e-07 5.72483241320837e-07 4140 2993.45454545455 3416 2.39677519131651e-08 1533 2.10791568744252 2.23996899562043 1 15.8104251771765 4138 3416 1563 1533 2082 4076 4017 3455 2479 1987 4182 3765 M15853 GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION.html A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. 389/501 Gene Ontology BP GO:0023014 7.29213007689558e-08 4.02645553947883e-07 4460 3264.09090909091 3416 6.62920938054623e-09 615 1.76509869926438 1.82068023855047 1 13.5486495632514 4458 3119 2801 2592 615 4291 4026 3720 3416 2680 4187 3766 M11124 GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that activates or increases the frequency, rate or extent of viral genome replication. 37/50 Gene Ontology BP GO:0045070 5.00214656713769e-07 8.86328559668381e-07 3245 3344.63636363636 3417 4.54740700407056e-08 2579 1.44693820339503 -1.69866050894022 -1 10.4882866793141 3241 3960 3668 3599 2579 4062 2749 2679 3417 3765 3072 3767 M13289 GO_PROTEIN_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MANNOSYLATION.html The addition of a mannose residue to a protein acceptor molecule. 20/21 Gene Ontology BP GO:0035268 6.54576477517349e-08 4.02645553947883e-07 2435 3023.63636363636 3417 5.95069542721161e-09 492 1.31466939060863 1.46462874202387 1 10.064944052104 2434 4504 3683 4345 492 3326 3417 1364 3626 3884 2185 3768 M14705 GO_ACTIVATION_OF_MAPKKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKKK_ACTIVITY.html Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). 12/13 Gene Ontology BP GO:0000185 4.42694776460942e-06 5.55218004008831e-06 1675 2993.45454545455 3417 4.0245060661415e-07 1032 1.26892493153642 0.786871172803013 1 7.96236944919252 1675 3828 3289 3557 3685 1552 1032 4549 2252 4092 3417 3769 M12508 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that activates or increases the frequency, rate or extent of response to oxidative stress. 13/22 Gene Ontology BP GO:1902884 3.63527469778552e-05 4.02812147413706e-05 1170 2472.36363636364 3418 3.30484978942424e-06 206 1.50845038509421 -1.50845038509421 -1 7.91472342129412 1170 4300 3418 3614 4566 814 206 438 4380 3897 393 3770 M14541 GO_POSITIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WOUND_HEALING.html Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 52/85 Gene Ontology BP GO:0090303 1.48708223644291e-07 4.36901586057683e-07 3945 3173.27272727273 3418 1.35189303360156e-08 1226 2.43624627479825 -2.46986086417208 -1 18.6349508354571 3942 3687 1226 2952 1486 4542 4069 3195 4134 2255 3418 3771 M14145 GO_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT.html Any process that modulates the frequency, rate or extent of protein import. 242/325 Gene Ontology BP GO:1904589 1.42408304780661e-07 4.2854237685504e-07 4280 3101.18181818182 3419 1.29462103635364e-08 1444 1.96787570962602 1.96507307389979 1 15.0525381983852 4277 3419 2506 1450 1444 4582 4043 3782 1780 3425 3405 3772 M15432 GO_NEUTROPHIL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a neutrophil. 20/36 Gene Ontology BP GO:0002446 5.04652188735842e-06 6.27008447046161e-06 625 2386.54545454545 3420 4.58775769407168e-07 234 1.30706848248941 -1.47748902998826 -1 8.12133110073901 472 3552 3420 4513 3721 621 234 1216 3993 3887 623 3773 M13502 GO_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SUMOYLATION.html The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. 132/158 Gene Ontology BP GO:0016925 2.01312213073217e-06 2.71351601225284e-06 565 2652.36363636364 3421 1.83011270259367e-07 448 1.4969363162536 1.63378095872231 1 9.97452396431166 564 4366 3979 4428 3421 688 448 1937 3502 4453 1390 3774 M10232 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. 20/23 Gene Ontology BP GO:0070230 2.0138832039617e-06 2.71356490418046e-06 4630 3246.63636363636 3422 1.83080458861426e-07 357 2.70072325116722 2.80501557182497 1 18.0784776814992 4629 3295 1769 2781 3422 4455 3787 3525 357 3052 4641 3775 M10662 GO_IRON_COORDINATION_ENTITY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_COORDINATION_ENTITY_TRANSPORT.html The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 10/13 Gene Ontology BP GO:1901678 0.000288786411892236 0.000302572207731271 1450 2634.18181818182 3422 2.62567569869451e-05 666 1.29147139269836 -1.29147139269836 -1 5.39364261575144 1449 3855 3422 4335 4643 1173 666 905 4058 3629 841 3776 M14179 GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION.html The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. 8/21 Gene Ontology BP GO:0043046 2.63954327286536e-07 5.72787891150211e-07 3680 3096.72727272727 3423 2.6395435863889e-08 658 1.58754396363577 -1.11472682024658 -1 11.8815158409525 3677 4316 4478 3907 2154 3632 3269 1220 658 3330 3423 3777 M14717 GO_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEPHOSPHORYLATION.html The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. 259/325 Gene Ontology BP GO:0016311 9.89221061625899e-08 4.02645553947883e-07 4355 3231.18181818182 3423 8.99291914641661e-09 989 1.6901286582577 1.85614419280135 1 12.9688170789814 4353 2357 3313 3855 989 2878 3541 4382 2197 3423 4255 3778 M12472 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of smooth muscle cell proliferation. 83/99 Gene Ontology BP GO:0048661 4.61469062982255e-07 8.38756074240794e-07 3745 3310.90909090909 3424 4.19517417981289e-08 1682 1.91210827070063 -1.81560010797645 -1 13.9486265538643 3741 3185 2305 3337 2510 4027 3424 4414 3522 1682 4273 3779 M13491 GO_REGULATION_OF_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_CYCLE.html Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. 47/54 Gene Ontology BP GO:0046605 1.37017303801435e-06 1.93370189441333e-06 3550 3334 3427 1.24561262851543e-07 1928 1.14602943204348 1.25781093762679 1 7.8161345989493 3547 1928 3738 3277 3267 3479 2990 3160 3786 3427 4075 3780 M15711 GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. 16/18 Gene Ontology BP GO:0060055 9.57327839480646e-08 4.02645553947883e-07 3900 3156.72727272727 3427 8.70298073762435e-09 951 1.65555401436204 -1.20818536467149 -1 12.7014102402818 3898 2200 2651 3427 951 4080 4378 3687 2813 2871 3768 3781 M14172 GO_ZINC_II_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_II_ION_TRANSPORT.html The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/27 Gene Ontology BP GO:0006829 1.75654334804771e-06 2.40671266150353e-06 3165 3361.81818181818 3428 1.59685886411279e-07 1528 1.56151305348693 -1.44113731275716 -1 10.5076648516705 3163 3780 3428 4147 3365 2913 1528 3741 3624 3388 3903 3782 M16557 GO_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PROCESS.html The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 35/73 Gene Ontology BP GO:0050886 1.83930872301502e-07 4.7749337740829e-07 4550 2974.81818181818 3428 1.67209897890031e-08 1522 2.02284202703348 1.9899021420635 1 15.3609414417034 4546 2534 1522 3428 1709 3766 1541 3834 4147 2029 3667 3783 M15490 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN.html The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. 17/41 Gene Ontology BP GO:0003081 1.85529798948346e-08 2.81195490067314e-07 3810 2898.18181818182 3429 1.68663455011774e-09 12 1.8018705779367 1.51249211615674 1 14.172815723966 3810 1005 1980 3383 12 4211 3429 3936 3572 2188 4354 3784 M10612 GO_CELLULAR_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 84/108 Gene Ontology BP GO:0034644 5.39525468101923e-05 5.88745779333548e-05 3330 3325.09090909091 3430 4.90489727106094e-06 1595 1.76535781970578 2.09945518762037 1 8.9283269369153 3329 4387 3506 3325 4236 2471 3430 1595 4039 4262 1996 3785 M10666 GO_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COAGULATION.html Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. 93/144 Gene Ontology BP GO:0050818 1.66557144570095e-12 5.78351040063172e-11 4330 2527.18181818182 3431 1.51415585972928e-13 84 2.69297943839262 -2.36585467759875 -1 33.2403781467253 4328 115 84 1703 1854 4004 3431 4161 3687 141 4291 3786 M12798 GO_MAINTENANCE_OF_LOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION.html Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. 157/197 Gene Ontology BP GO:0051235 2.35029182143484e-07 5.3972042302237e-07 4290 3146.36363636364 3432 2.13662915683632e-08 1961 1.92822885525924 1.99955231972133 1 14.5135921732771 4290 3432 2234 2393 1961 4168 3680 4462 2176 2015 3799 3787 M16732 GO_THYROID_HORMONE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_GENERATION.html The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. 6/13 Gene Ontology BP GO:0006590 5.53601709228506e-05 6.03822961331514e-05 3435 3266.90909090909 3433 5.53615501080431e-06 552 2.66372878093356 -2.78939335808854 -1 13.4888693038203 3593 3398 4644 3434 4466 3904 3254 552 3433 2252 3006 3788 M11648 GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 10/13 Gene Ontology BP GO:0032352 0.000111432396937765 0.000119002741095116 3435 3305.09090909091 3435 1.01307310463952e-05 2148 1.74652797984088 -1.56098649306965 -1 8.18643246765266 3435 3851 2833 3024 4330 3689 2597 2896 3491 2148 4062 3789 M12485 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. 105/127 Gene Ontology BP GO:2001243 5.85553431207235e-07 9.96919178707379e-07 3435 3487.27272727273 3435 5.32321442780522e-08 2692 1.70656030413261 1.75993040489845 1 12.2832649155534 4193 3902 3353 2811 2692 3435 3820 4112 3043 3431 3568 3790 M10972 GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. 21/28 Gene Ontology BP GO:0033032 7.04180747964057e-06 8.47969208146159e-06 3545 3253.90909090909 3438 6.40166365391903e-07 1603 1.92976894614529 -1.97575383363282 -1 11.7334800492611 3541 3768 3050 2615 3837 3594 1603 4434 2491 3438 3422 3791 M13321 GO_REGULATION_OF_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 19/23 Gene Ontology BP GO:0044030 6.69427476086353e-07 1.09432305313226e-06 3395 3386.90909090909 3438 6.0857061798484e-08 1862 1.14408948938472 0.934840402647213 1 8.14483084400362 3395 3776 3642 3295 2800 2673 1862 4199 3438 3571 4605 3792 M15106 GO_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 115/138 Gene Ontology BP GO:0010827 2.5768025699892e-07 5.67433145203964e-07 4045 3528.81818181818 3439 2.34254806527583e-08 2053 1.74499609698433 -1.79663210277059 -1 13.0787409015066 4045 3442 2984 3319 2053 4405 4539 3859 3439 3391 3341 3793 M13054 GO_REGULATION_OF_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_LOCALIZATION.html Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. 1317/1866 Gene Ontology BP GO:0060341 7.69929497717314e-08 4.02645553947883e-07 3960 2598.18181818182 3440 7.69929524392929e-09 268 2.00224992710247 -1.86208677833175 -1 15.3828220371975 3956 1320 4404 384 801 4258 3440 4176 1720 268 3853 3794 M14037 GO_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 920/1440 Gene Ontology BP GO:0033993 4.80373763671785e-14 1.97803462156179e-12 4000 2687.54545454545 3440 4.80373763671794e-15 70 2.25295991637121 2.27638801987086 1 31.7865715077763 4000 1358 4469 365 605 3440 4233 4375 2432 70 4216 3795 M16446 GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT.html The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. 42/58 Gene Ontology BP GO:0031076 6.30779099837839e-06 7.66923217022594e-06 3705 3339.72727272727 3441 5.73437189455349e-07 1983 2.1880769699179 2.54555474990268 1 13.4332903973998 3702 3218 1983 2537 3799 3490 3892 4234 3163 3278 3441 3796 M12493 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. 21/27 Gene Ontology BP GO:0050687 4.40329905532624e-08 4.02645553947883e-07 3845 3080.18181818182 3442 4.00299922132568e-09 171 1.98848998944934 2.24733565848445 1 15.2764000754955 3844 2986 3065 3503 171 4566 3750 3637 1681 3442 3237 3797 M16295 GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. 17/20 Gene Ontology BP GO:0000028 0.0118543377384366 0.0120170443348465 4650 3423.18181818182 3442 0.00108351808467674 1449 0.505483281097855 -0.469617037266473 -1 1.07091975743519 1938 4304 4003 3355 4569 2294 1449 3442 4646 4648 3007 3798 M16695 GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERAD pathway. 17/17 Gene Ontology BP GO:1904294 5.38059972376187e-08 4.02645553947883e-07 3790 3186.54545454545 3444 4.89145441396061e-09 308 1.43854716866407 1.96607837001622 1 11.0230382298749 3786 2676 3225 3597 308 3204 2831 4058 3803 4120 3444 3799 M12537 GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE.html Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. 10/13 Gene Ontology BP GO:0099500 5.14642093399483e-05 5.62780178751538e-05 2935 3423.63636363636 3447 4.67867393386252e-06 1887 1.37007322390117 -1.34769612406671 -1 6.93857322350485 2935 3853 3203 4156 4227 2808 1887 3249 4263 3632 3447 3800 M15910 GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE.html Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. 10/13 Gene Ontology BP GO:0031629 5.14642093399483e-05 5.62780178751538e-05 2940 3422 3448 4.67867393386252e-06 1888 1.37007322390117 -1.34769612406671 -1 6.93857322350485 2936 3854 3204 4157 4228 2809 1888 3218 4264 3636 3448 3801 M12893 GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT.html The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 21/44 Gene Ontology BP GO:0015697 8.75817875867221e-06 1.04277906254099e-05 1425 2662.63636363636 3450 7.96201238644691e-07 345 1.52910332197101 -1.36910448191187 -1 9.10986676033818 1423 4016 3450 3806 3882 1412 345 1282 3826 3944 1903 3802 M14384 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that increases the amount of sodium excreted in urine over a unit of time. 9/17 Gene Ontology BP GO:0035815 1.97717287106978e-06 2.67271238314676e-06 3950 3434.27272727273 3454 1.97717463021764e-07 1904 3.2824967059584 2.49266491634938 1 22.0211657332857 3947 3090 4489 3883 3454 4642 2478 2907 3671 1904 3312 3803 M14959 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 90/103 Gene Ontology BP GO:0043620 2.62319823590239e-06 3.4343673020973e-06 4260 3437.54545454545 3454 2.38472851246518e-07 2351 1.71130588665394 1.94756270942336 1 11.2059203862487 4256 3454 3152 2351 3521 4271 2689 3730 3140 3803 3446 3804 M10943 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html The directed movement of a protein to a specific location on a chromosome. 17/20 Gene Ontology BP GO:0070199 9.42424187347599e-05 0.000101155703430874 2500 3534.45454545455 3457 8.56785964391119e-06 2497 1.54455772789071 1.25185373697209 1 7.35965630388029 2500 4547 3271 4199 4310 2497 2719 3457 4272 3694 3413 3805 M14777 GO_POSITIVE_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SIZE.html Any process that increases cell size. 18/21 Gene Ontology BP GO:0045793 1.51213791168425e-06 2.1065801506188e-06 3510 3463.72727272727 3457 1.37467177366472e-07 2358 1.68884138924003 1.36966267252063 1 11.4910222630279 3508 4044 3216 3611 3308 3818 3154 2358 3385 3457 4242 3806 M14751 GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. 13/19 Gene Ontology BP GO:0071071 1.71211217665644e-07 4.59245216956312e-07 3930 3379.72727272727 3458 1.55646573627149e-08 1651 1.61064953885194 1.70955268588755 1 12.2428422313279 3930 2713 2753 3458 1651 4388 3300 4508 4067 2300 4109 3807 M15581 GO_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 18/25 Gene Ontology BP GO:0000305 4.45779401007404e-06 5.58785439894248e-06 1125 2827.90909090909 3458 4.05254822072177e-07 521 1.26770868001888 -1.31322440969295 -1 7.95037435898762 1123 4549 3606 4555 3686 1497 521 1247 4614 3458 2251 3808 M15176 GO_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. 658/940 Gene Ontology BP GO:0030155 3.02202577021632e-18 2.46692735242395e-16 4485 2771.45454545455 3459 3.02202577021633e-19 31 2.17882050450213 2.3460927655571 1 41.0246423996404 4483 1399 4540 839 306 4622 3459 3645 2671 31 4491 3809 M16356 GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. 52/88 Gene Ontology BP GO:0043470 7.92079201316006e-08 4.02645553947883e-07 4460 3261.36363636364 3460 7.20072027121557e-09 714 1.54408718043454 1.76776095642673 1 11.8393046530094 4457 3480 3335 3084 714 3460 3206 3531 2903 3859 3846 3810 M11092 GO_WHITE_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_WHITE_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. 18/20 Gene Ontology BP GO:0050872 2.10305981733135e-06 2.81841512962061e-06 4360 3352 3463 1.91187438884111e-07 874 2.06381402316751 -2.02678244023541 -1 13.7496699439804 4145 3323 2501 3747 3442 4356 3520 874 3463 3145 4356 3811 M10992 GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. 15/16 Gene Ontology BP GO:0045910 6.14863977973093e-06 7.50317883427432e-06 670 2418.81818181818 3465 5.58968814930872e-07 629 1.10733545611769 1.1906458053019 1 6.76015755238426 666 3818 3635 3554 3785 756 629 1452 4127 3465 720 3812 M16070 GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS.html The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. 49/57 Gene Ontology BP GO:0006921 1.10657884814069e-06 1.6140788026328e-06 2485 3322.90909090909 3466 1.005981277036e-07 2485 1.64855304977411 -1.57727674037413 -1 11.445025141494 2485 3487 3337 3543 3159 3466 2807 3684 3190 3563 3831 3813 M14419 GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/49 Gene Ontology BP GO:0032369 2.24787615185979e-06 2.98753719925838e-06 4195 3280.81818181818 3470 2.04352586241568e-07 1469 1.90887864281515 -1.39983073417423 -1 12.6512938505404 4194 2549 2207 2109 3470 4423 2878 4576 3565 1469 4649 3814 M10907 GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 58/68 Gene Ontology BP GO:0048146 1.77343933739613e-07 4.68656867303793e-07 4645 3231.09090909091 3471 1.61221770941332e-08 1680 1.95910371975117 -1.99767464217845 -1 14.8929059375048 4642 2863 1905 3471 1680 4175 3616 4597 2104 1880 4609 3815 M14295 GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 26/34 Gene Ontology BP GO:0055094 8.34738941226043e-07 1.29814180933315e-06 3940 3297.54545454545 3473 7.58853870862298e-08 1441 2.37876495806985 2.73931844980949 1 16.8322610200694 3938 2959 1908 3473 2949 3819 4092 4475 3391 1441 3828 3816 M12169 GO_LATERAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. 6/14 Gene Ontology BP GO:0048368 3.73665519026488e-05 4.13672533911551e-05 1860 3095.81818181818 3474 3.73671802341592e-06 589 1.18611955989416 1.23440268552892 1 6.18490366254497 1860 4327 4351 4489 4189 2086 589 3474 4569 2935 1185 3817 M13263 GO_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 20/21 Gene Ontology BP GO:0090140 1.51345742825749e-05 1.74223587671501e-05 3110 3362.36363636364 3474 1.37587985451279e-06 1951 1.66617368320362 1.88404993337585 1 9.48652589151919 3109 4259 3474 4401 4016 2498 2074 1951 4273 3883 3048 3818 M12931 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. 27/35 Gene Ontology BP GO:0071634 5.68915399071543e-07 9.76813044974129e-07 4390 3148.27272727273 3475 5.17195951083571e-08 1480 1.84963892107927 -1.08101873271029 -1 13.3415238287158 4389 3737 2434 3497 2667 4072 3475 1480 3436 1934 3510 3819 M12266 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. 8/13 Gene Ontology BP GO:0043371 9.85787359524705e-07 1.47677674947471e-06 2390 3452.72727272727 3476 9.85787796824501e-08 2386 2.22597255469153 -2.82619915977516 -1 15.5937439403201 2386 3864 4358 3777 3143 3476 3336 3091 3579 3328 3642 3820 M10448 GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that stimulates, induces or increases the rate of macrophage activation. 11/16 Gene Ontology BP GO:0043032 5.68213682153049e-06 6.9870461497308e-06 3165 3175 3477 5.16559227031515e-07 706 2.5529673955945 -3.21494432312984 -1 15.8155536809648 3161 3594 2092 3477 3758 4172 4371 706 3884 3336 2374 3821 M15271 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 15/17 Gene Ontology BP GO:0044252 2.92300021875611e-06 3.78744639873912e-06 2860 3457.54545454545 3478 2.65727645669819e-07 2479 1.68579322922657 -1.90455952367277 -1 10.9506760264981 2859 4288 2957 3954 3566 4118 3203 2479 4274 3478 2857 3822 M16221 GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA.html The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. 28/60 Gene Ontology BP GO:0007339 0.000500375625274185 0.000519350386883958 3485 3277.81818181818 3483 4.54990426084076e-05 1012 1.91310142709367 1.96346834713567 1 7.49648061620199 3483 3989 3434 3624 4458 2135 1012 3425 4235 4106 2155 3823 M13654 GO_RECEPTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 85/123 Gene Ontology BP GO:0043112 2.06500312020478e-07 5.01485361081046e-07 4275 3387.90909090909 3484 1.87727574003073e-08 1840 1.7879407540855 1.93306767629152 1 13.5191677701111 4271 2839 2854 3484 1840 4431 3871 3829 2715 2603 4530 3824 M11589 GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 859/1065 Gene Ontology BP GO:0044087 6.76794898925412e-08 4.02645553947883e-07 4340 2781.45454545455 3485 6.76794919537722e-09 493 1.94600183683778 2.12882038860262 1 14.9477886628565 4338 1374 4314 493 642 4461 3485 4189 1813 1897 3590 3825 M13235 GO_GLYOXYLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYOXYLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. 26/32 Gene Ontology BP GO:0046487 2.17843355740265e-06 2.90853697061536e-06 4005 3530.81818181818 3485 1.98039610407652e-07 2756 1.48131904197431 0.916731930086066 1 9.81538751207645 4001 3991 3485 3805 3455 2756 2903 2806 3411 3850 4376 3826 M10127 GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION.html Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. 20/22 Gene Ontology BP GO:0051900 2.36787055567967e-06 3.12906040489703e-06 4605 3331.54545454545 3486 2.15261191293995e-07 1513 2.44460952514262 2.57316741620722 1 16.1713743268889 4601 2157 1513 2730 3486 4263 4305 4398 2461 2273 4460 3827 M14166 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. 13/21 Gene Ontology BP GO:0032717 0.00105080394141019 0.00108316143982757 1485 2926.63636363636 3486 9.55732892129879e-05 1190 1.09129824221217 -1.18275959084797 -1 3.81069325015816 1483 4305 3486 4380 4642 2001 1310 1302 4484 3610 1190 3828 M11368 GO_POSTREPLICATION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTREPLICATION_REPAIR.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. 60/72 Gene Ontology BP GO:0006301 2.36848285967061e-06 3.12906040489703e-06 2090 3157.36363636364 3487 2.1531685541301e-07 1481 1.24881375341469 1.28044184633324 1 8.21068475907825 2090 4163 3802 4362 3487 1481 1822 2877 3951 3688 3008 3829 M11883 GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. 16/22 Gene Ontology BP GO:0035067 1.82148225384993e-05 2.07525879705282e-05 2755 3067.45454545455 3488 1.65590666811175e-06 851 0.690473561252931 0.67782314379683 1 3.80755327114645 2754 3572 3892 2347 4059 1564 851 3488 4598 4234 2383 3830 M12317 GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. 118/140 Gene Ontology BP GO:0007006 2.37112131983171e-06 3.13165696882684e-06 2100 3387.72727272727 3488 2.15556715944403e-07 2096 1.34753450932752 1.52046944230314 1 8.86730462769875 2096 4134 4037 3846 3488 2468 2901 2827 3685 4364 3419 3831 M15860 GO_REGULATION_OF_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PERMEABILITY.html Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. 93/113 Gene Ontology BP GO:0090559 7.0398135389842e-07 1.13500528055764e-06 3230 3385.09090909091 3488 6.39983253787808e-08 2669 1.50555500712274 1.74038461900134 1 10.7217866181651 3229 3667 3658 3339 2842 2669 3637 3154 3488 3984 3569 3832 M10674 GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 47/65 Gene Ontology BP GO:0009247 1.30761048738971e-05 1.51652831451254e-05 4215 3481.81818181818 3490 1.18874387225269e-06 1717 1.76894319470139 -1.79525051590352 -1 10.2069146831332 4211 3490 3136 2702 3985 4432 4106 2855 1717 3226 4440 3833 M11143 GO_POSITIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COAGULATION.html Any process that activates or increases the frequency, rate or extent of coagulation. 24/46 Gene Ontology BP GO:0050820 2.38871845533355e-06 3.15310836104029e-06 4505 3294.27272727273 3490 2.17156458996626e-07 1373 2.46047010385596 -2.39417460284602 -1 16.2670678704602 4502 2598 1373 2886 3490 3698 4346 2641 4203 2880 3620 3834 M15781 GO_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 40/56 Gene Ontology BP GO:0046686 2.93130960150768e-07 6.1534076669006e-07 3080 3348.54545454545 3490 2.66482726552672e-08 2158 2.02856537008088 -2.24459492517963 -1 15.1344628486701 3080 3496 2633 3490 2158 4015 3880 4088 2869 3764 3361 3835 M16230 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. 166/197 Gene Ontology BP GO:2001242 2.05504760880977e-07 5.00119458251237e-07 4480 3421.90909090909 3491 1.86822527343125e-08 1801 1.95167027222446 2.08822993570891 1 14.7694009557167 4477 4123 2886 2784 1834 4208 4184 4470 1801 3383 3491 3836 M13722 GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 116/172 Gene Ontology BP GO:0010906 1.07793093779156e-06 1.58089875652441e-06 3765 3393.72727272727 3492 9.79937696312949e-08 3021 1.78632272585228 -1.47649658900982 -1 12.4295787942133 3763 3660 3026 3530 3137 3099 3149 3731 3492 3021 3723 3837 M13286 GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 85/104 Gene Ontology BP GO:0042158 2.40060269064974e-06 3.16596937018531e-06 3495 3284.54545454545 3493 2.18236846377335e-07 595 1.58700746126372 -1.2281157688666 -1 10.4523439928395 3362 3911 3810 3508 3494 3265 3019 3456 595 4217 3493 3838 M12633 GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 12/15 Gene Ontology BP GO:0006244 7.56969984777241e-06 9.0848112952502e-06 2915 3222.18181818182 3495 6.88156899410376e-07 1675 2.15730832824312 1.74032352620746 1 13.0510125707118 2915 4097 3268 3539 3852 2455 1675 2735 3574 3495 3839 3839 M16675 GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 188/214 Gene Ontology BP GO:0035966 2.9985062517482e-07 6.23973595231859e-07 3170 3683.27272727273 3495 2.72591514584718e-08 2177 1.23507950901933 -1.2257841906891 -1 9.16521406648528 3168 4652 4160 4618 2177 3495 2959 3352 4162 4513 3260 3840 M11395 GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of intracellular signal transduction. 1666/2243 Gene Ontology BP GO:1902531 4.06951347878954e-08 4.02645553947883e-07 4095 2816.63636363636 3496 4.06951355331377e-09 174 1.94157008452676 -1.74292590478654 -1 14.9135126518305 4092 1301 4296 1465 733 4279 3496 4360 2591 174 4196 3841 M11899 GO_ADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. 44/64 Gene Ontology BP GO:0046031 9.78720058560186e-06 1.15671435927878e-05 2285 3259.27272727273 3497 8.89749466041983e-07 1848 1.55190794799449 1.45095964746276 1 9.16274150524394 2283 4190 3497 3519 3910 2517 1848 3594 3082 4146 3266 3842 M13051 GO_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that modulates the frequency, rate or extent of a response to a food stimulus. 13/22 Gene Ontology BP GO:0032095 1.51032735235069e-06 2.10468798157764e-06 4160 3283.09090909091 3498 1.3730258083729e-07 1591 2.35030100632756 1.95388009416802 1 16.0330847172757 4159 4076 2143 3727 3307 4421 4507 1591 1902 2783 3498 3843 M13459 GO_ERYTHROCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. 12/16 Gene Ontology BP GO:0043249 1.1976007789929e-05 1.3966006076827e-05 3090 3597.81818181818 3498 1.08873390759089e-06 1929 0.907732475407429 -0.955494991904192 -1 5.22682678454563 3090 3370 3448 4490 3963 4069 4392 1929 4374 3498 2953 3844 M12894 GO_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXIT_FROM_MITOSIS.html The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. 15/16 Gene Ontology BP GO:0010458 5.7114814582026e-06 7.02127429987231e-06 3835 3322.72727272727 3499 5.19226935090279e-07 1566 1.52652588342621 -0.89458148004045 -1 9.4114671893386 3834 3033 2948 3703 3759 3499 2974 3520 1566 3132 4582 3845 M14918 GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. 16/34 Gene Ontology BP GO:0022400 1.04388950319533e-06 1.54148456311262e-06 3500 3403.72727272727 3500 9.48990907742042e-08 1702 1.18059688109405 -1.12875845082493 -1 8.19556500307768 3500 3021 3455 2984 3114 4055 3869 4038 1702 3855 3848 3846 M12323 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of striated muscle contraction. 18/27 Gene Ontology BP GO:0045989 2.45439084488551e-06 3.23063100459753e-06 3850 3447.18181818182 3501 2.23126689371568e-07 1955 2.28184631604919 -2.75438980760173 -1 15.0495360469732 3846 3559 2155 3461 3501 3370 4460 3493 3595 1955 4524 3847 M13946 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. 12/13 Gene Ontology BP GO:0040015 1.93164390654284e-05 2.19057740607942e-05 4405 3550.90909090909 3501 1.75605533360939e-06 2404 2.52424134673429 -2.55751380172176 -1 14.1214351017911 4402 3384 2607 3534 4079 4488 3379 2891 2404 3501 4391 3848 M15655 GO_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_LOCALIZATION.html Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. 47/54 Gene Ontology BP GO:0051646 2.38516848862136e-06 3.1493158279101e-06 4620 3320.45454545455 3501 2.16833734049767e-07 1887 2.03363910093745 2.64341783943444 1 13.4285568563568 4616 3696 2819 2806 3489 4403 3501 1887 2038 3621 3649 3849 M10846 GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 101/144 Gene Ontology BP GO:0071482 1.01356436183441e-05 1.19486064748303e-05 3505 3501.36363636364 3502 9.2142639224344e-07 2070 1.78853420788628 2.11802700561228 1 10.5450438063201 3502 4141 3327 3293 3921 3107 4448 2070 3919 3933 2854 3850 M11924 GO_NUCLEAR_PORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. 16/17 Gene Ontology BP GO:0006999 0.000262070829204637 0.000275138891761999 2250 3373.72727272727 3502 2.38274593729759e-05 2250 1.12361166735437 1.06811845025654 1 4.73530995875033 2250 3819 3808 3318 4411 3142 2260 2765 4256 3580 3502 3851 M13141 GO_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 12/19 Gene Ontology BP GO:0070528 4.08916517420021e-06 5.15214881006055e-06 4335 3419.63636363636 3502 3.71742979527099e-07 2491 1.97164297546461 -1.76323019534993 -1 12.5063046696905 4334 3072 2803 2516 3666 3502 2491 4037 4231 3081 3883 3852 M12111 GO_INNER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 36/63 Gene Ontology BP GO:0036159 1.38849008510031e-07 4.25322209741392e-07 4380 2993.72727272727 3503 1.26226379339305e-08 1417 2.52019817379559 2.38968226217877 1 19.3162060444092 4380 3709 1816 3714 1417 3652 4465 1522 2030 2723 3503 3853 M14986 GO_HISTONE_H3_K4_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_TRIMETHYLATION.html The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. 16/18 Gene Ontology BP GO:0080182 0.00158298884157869 0.00162597065780698 725 3046.45454545455 3503 0.000144011728609234 722 1.46834412503715 -1.53794443625292 -1 4.84958028286418 722 4292 3279 3610 4513 1821 908 3503 4488 3856 2519 3854 M12770 GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. 20/22 Gene Ontology BP GO:0061029 2.47373143950346e-06 3.25332741323052e-06 4070 3234 3504 2.24884929184483e-07 1783 2.16772700908613 1.96706360352005 1 14.2837612350743 4070 2626 1783 3756 3504 4490 4216 3349 3585 2278 1917 3855 M16326 GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. 17/22 Gene Ontology BP GO:2000479 0.183727488544769 0.184440993354652 4425 3272.09090909091 3505 0.0182859295083989 95 2.28379618808804 -2.17394353874456 -1 1.92475642625968 4425 4042 2373 2274 4653 4178 3505 3181 95 3380 3887 3856 M13726 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. 42/48 Gene Ontology BP GO:0008625 1.42553684394227e-07 4.2854237685504e-07 3465 3382.54545454545 3506 1.29594266937543e-08 1446 1.71996635695385 -1.69104368886487 -1 13.1432767629047 3465 4191 3411 3975 1446 4079 4052 2338 3506 3986 2759 3857 M12553 GO_EPITHELIAL_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. 38/60 Gene Ontology BP GO:0003351 1.02432092236304e-06 1.51547384793489e-06 3800 3289.90909090909 3510 9.31201272079639e-08 1376 2.12055838209819 1.94956527836015 1 14.8215941015162 3798 4196 2543 4149 3105 3510 4436 1376 1588 3415 4073 3858 M14570 GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 29/48 Gene Ontology BP GO:0006509 1.92092305636477e-06 2.60281158452687e-06 3885 3252 3510 1.74629521237702e-07 601 1.75534832314816 -0.952756541698884 -1 11.7525747566975 3885 3510 2877 3754 3403 3269 2906 4044 601 3844 3679 3859 M16503 GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. 175/203 Gene Ontology BP GO:2001020 1.8467476910392e-07 4.77959302622087e-07 3275 3426.27272727273 3510 1.67886167823719e-08 1714 1.60489053201611 1.74624901718337 1 12.1650305691336 3272 4352 3545 4213 1714 2653 2823 4021 3112 3510 4474 3860 M11981 GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. 896/1152 Gene Ontology BP GO:0051345 5.43810415031048e-08 4.02645553947883e-07 4110 2663.81818181818 3511 5.43810428338887e-09 251 1.96299110733881 -1.8373616917401 -1 15.0791868959143 4106 1370 4337 681 401 4023 3511 3922 2661 251 4039 3861 M14994 GO_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_ACTIVATION.html Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 37/56 Gene Ontology BP GO:0010543 6.2330448740205e-07 1.043250280533e-06 3515 2486.54545454545 3511 5.66640603633533e-08 404 2.64117633310824 3.15091590872138 1 19.0036948624102 3511 613 404 784 2738 3687 3772 3553 3825 455 4010 3862 M11609 GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 865/1229 Gene Ontology BP GO:1901701 7.11493939027193e-08 4.02645553947883e-07 700 2788.36363636364 3513 7.11493961807255e-09 226 2.14126526901171 2.275952436366 1 16.4579929984047 4620 1372 4315 696 700 4575 3513 3895 2167 226 4593 3863 M16901 GO_FLUID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLUID_TRANSPORT.html The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/31 Gene Ontology BP GO:0042044 2.51487584897166e-06 3.29997668507195e-06 4570 3180.63636363636 3513 2.2862533852679e-07 746 3.21265087155611 -2.80326416264298 -1 21.1946634266513 4566 2608 746 2652 3513 3968 4046 3868 3422 946 4652 3864 M13026 GO_RESPONSE_TO_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 935/1432 Gene Ontology BP GO:0009725 5.78194694194725e-08 4.02645553947883e-07 4295 2695.72727272727 3514 5.78194709238634e-09 205 2.13191394967613 2.19442459743555 1 16.3856681250454 4291 1357 4401 368 457 4572 3514 4102 2253 205 4133 3865 M11789 GO_SEQUESTERING_OF_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUESTERING_OF_METAL_ION.html The process of binding or confining metal ions such that they are separated from other components of a biological system. 12/22 Gene Ontology BP GO:0051238 1.72821048833168e-06 2.37208359947118e-06 3515 3583.54545454545 3515 1.57110167811755e-07 2437 3.31486228406577 -2.47059349156317 -1 22.4470652693785 3515 4585 2618 4516 3358 4229 3824 3759 2437 3078 3500 3866 M16770 GO_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METABOLIC_PROCESS.html Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. 750/1006 Gene Ontology BP GO:0006259 2.30518518173744e-06 3.05236956477642e-06 625 2810.81818181818 3516 2.30518757298636e-07 482 1.27695575749166 1.37951816376306 1 8.41467576975624 623 4112 4646 4455 3516 482 652 1978 3813 4581 2061 3867 M12471 GO_LAGGING_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAGGING_STRAND_ELONGATION.html The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. 11/11 Gene Ontology BP GO:0006273 0.000252598162429776 0.00026537350412864 910 2636.27272727273 3521 2.2966106340309e-05 62 1.22860439978206 1.22860439978206 1 5.21072817180013 908 4102 3521 4191 4510 614 62 1064 4285 4028 1714 3868 M13628 GO_DNA_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION.html The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. 30/31 Gene Ontology BP GO:0022616 0.00016101746054288 0.000170741623497269 130 2509.90909090909 3521 1.46390224162741e-05 60 1.16558053058139 1.20542540360027 1 5.20812493967569 126 3521 3776 3569 4368 439 60 1662 4232 3730 2126 3869 M11449 GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 10/12 Gene Ontology BP GO:0046349 0.000275456510968104 0.000288801069295761 2280 3097.45454545455 3522 2.50446369306744e-05 883 1.42197303187439 -1.66267940144283 -1 5.98385806588061 2277 4325 3522 4203 4646 2335 1602 883 4280 3964 2035 3870 M16510 GO_ERYTHROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. 26/33 Gene Ontology BP GO:0048821 2.43063411854131e-05 2.73314174808427e-05 1365 2819.36363636364 3523 2.20969179401938e-06 1189 1.04790919515423 -1.11868119520973 -1 5.68033637392292 1365 3523 3633 3778 4115 1613 1189 1696 4281 3852 1968 3871 M11823 GO_NAD_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 51/75 Gene Ontology BP GO:0019674 2.63270442505701e-06 3.44390601343555e-06 3065 3317.36363636364 3524 2.39337052325191e-07 1757 1.55672256064852 -2.07060377916393 -1 10.1821145783506 3061 3938 3662 3964 3524 3238 3805 2001 3311 4230 1757 3872 M13922 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). 202/264 Gene Ontology BP GO:0097193 2.77364965086087e-07 5.92008799332827e-07 4635 3425.36363636364 3524 2.52150000049888e-08 2122 1.75393456293833 2.1064151430097 1 13.1072033595965 4635 3641 3101 3310 2122 4378 3524 3115 2412 3540 3901 3873 M15231 GO_ISOPRENOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 25/33 Gene Ontology BP GO:0008299 2.79381019430573e-06 3.6332025808006e-06 2470 3292.54545454545 3524 2.53983067473631e-07 1640 1.89077127474429 1.71943670429454 1 12.3359939643059 2468 3999 2921 3516 3550 2871 1640 4219 3949 3561 3524 3874 M15614 GO_PROTEIN_PALMITOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PALMITOYLATION.html The covalent attachment of a palmitoyl group to a protein. 21/26 Gene Ontology BP GO:0018345 3.37204160261951e-07 6.78885086482941e-07 3655 3157.18181818182 3524 3.06549283588001e-08 515 1.61613510553056 -1.03560150771735 -1 11.953101726468 3652 3538 3256 3710 2256 3524 2891 3603 515 3447 4337 3875 M12036 GO_ASYMMETRIC_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_CELL_DIVISION.html The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. 18/19 Gene Ontology BP GO:0008356 1.71905594157206e-05 1.96336948849651e-05 4050 3327.36363636364 3527 1.56279034021286e-06 1889 1.21482036827055 1.07842845791427 1 6.8125660755748 2950 3784 3527 3952 4046 2171 1889 4050 3407 3994 2831 3876 M13560 GO_BICARBONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSPORT.html The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/52 Gene Ontology BP GO:0015701 6.99565302827546e-06 8.4306587776653e-06 3530 3383 3527 6.35970479404345e-07 1971 2.49171522219875 -2.79306527136355 -1 15.1878254234927 3527 3753 1971 4314 3834 3483 2694 3547 3878 2886 3326 3877 M16726 GO_PHAGOCYTOSIS_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_RECOGNITION.html The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. 14/130 Gene Ontology BP GO:0006910 1.49626609078735e-08 2.37615225953363e-07 3740 2550.54545454545 3527 1.36024190996706e-09 5 2.76750597694495 2.48990438524267 1 22.0680862381815 3736 1099 994 4098 5 3906 3527 2229 3586 1213 3663 3878 M12528 GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING.html Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. 16/18 Gene Ontology BP GO:0006349 4.74887504865385e-07 8.53476848257489e-07 4155 3591.18181818182 3528 4.3171600670333e-08 2540 2.4570589397413 1.98290114761137 1 17.9308734032013 4152 4045 2674 3528 2540 4188 4343 3518 4031 3234 3250 3879 M15218 GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. 15/17 Gene Ontology BP GO:0034314 2.13726984217255e-06 2.86014281726456e-06 4600 3738.72727272727 3528 1.94297447136702e-07 1948 1.19845717487293 1.24488685449308 1 7.93201438638962 4598 3341 3528 2777 3446 4636 4590 4554 1948 3477 4231 3880 M12221 GO_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_EXTRAVASATION.html The migration of a leukocyte from the blood vessels into the surrounding tissue. 29/37 Gene Ontology BP GO:0045123 1.02066878621224e-06 1.51111922298151e-06 2905 3115.09090909091 3529 9.27881145219985e-08 1151 2.35085818163829 2.50631973056686 1 16.4460039195121 2905 2040 1151 3876 3102 3529 4435 3586 4138 1873 3631 3881 M16361 GO_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 433/581 Gene Ontology BP GO:0006979 3.4093431128957e-07 6.83484425002314e-07 4135 3317.27272727273 3529 3.09940331022018e-08 2054 1.87477103434262 2.03408415989717 1 13.8758277542943 4134 3408 2054 4159 2265 3605 4226 3555 3048 2507 3529 3882 M16613 GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. 20/21 Gene Ontology BP GO:0034616 1.03743275504161e-05 1.22052455352936e-05 3550 3446 3529 9.43125133813973e-07 2538 1.52620864389518 -1.25279933300655 -1 8.96625865327682 3549 3778 3286 3529 3927 3921 2538 2717 3475 3063 4123 3883 M10200 GO_N_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_GLYCAN_PROCESSING.html The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. 17/20 Gene Ontology BP GO:0006491 2.6705557080806e-06 3.48949612740776e-06 4420 3353.09090909091 3531 2.42778086349472e-07 1866 1.58231632014432 1.76398883917205 1 10.3402796916594 4416 2646 2821 2701 3531 4101 2763 3838 1866 3693 4508 3884 M12925 GO_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. 693/922 Gene Ontology BP GO:0043603 3.07277765837374e-07 6.35759491824382e-07 2515 3657.36363636364 3531 3.07277808326213e-08 2260 1.40524935127935 -1.39749939045466 -1 10.4283759294221 2511 4608 4394 4622 2260 3828 3347 3185 3360 4585 3531 3885 M10217 GO_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_RECOMBINATION.html Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. 57/91 Gene Ontology BP GO:0000018 4.96539954920735e-06 6.17588989640786e-06 1910 3129.36363636364 3534 4.51400977831684e-07 1906 1.35977177837758 1.42381319451143 1 8.46375958758983 1906 4169 3853 4000 3717 2123 2135 2215 3777 3534 2994 3886 M13409 GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. 10/12 Gene Ontology BP GO:0070897 2.30646696331475e-05 2.59791594778589e-05 2900 3403.09090909091 3534 2.09681013139331e-06 2112 0.948799359535906 0.765427339258985 1 5.15864721088612 2899 4099 3534 4175 4109 2777 2209 2112 4385 3967 3168 3887 M11225 GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. 342/480 Gene Ontology BP GO:1903651 1.09405347553777e-07 4.02645553947883e-07 2345 3353.72727272727 3535 9.94594118131570e-09 1138 1.7574593533802 1.81055902042026 1 13.4895654165344 4375 2341 3154 2342 1138 4035 4651 4593 2263 3535 4464 3888 M11960 GO_GLUTAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. 22/24 Gene Ontology BP GO:0006541 1.09829188687893e-05 1.28691819432074e-05 2310 3042.27272727273 3535 9.98452154408526e-07 721 1.17238251311454 1.06897113605818 1 6.83109399448891 2309 3535 3686 4142 3949 1444 721 3088 3738 4004 2849 3889 M15375 GO_PROTEIN_K63_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. 25/32 Gene Ontology BP GO:0070536 0.000113796428582331 0.00012138807478074 2225 3034.45454545455 3535 1.03456650184349e-05 776 1.45916995670285 -1.43287528288382 -1 6.80736047150039 2221 4000 3535 4242 4334 2362 2118 776 4102 4129 1560 3890 M13792 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. 137/189 Gene Ontology BP GO:1903747 1.52353065482293e-07 4.38675008470983e-07 3325 3431.18181818182 3537 1.38502796393596e-08 1520 1.30361645335556 1.42698344858707 1 9.92077787709247 3325 3652 4020 4589 1520 2801 3377 2876 3762 4284 3537 3891 M12863 GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). 13/17 Gene Ontology BP GO:1901070 1.86629102241782e-06 2.53839582791877e-06 2290 3552.18181818182 3538 1.69662964147336e-07 2290 0.71537029669126 0.81021183544625 1 4.73803244409959 2290 3822 3782 4209 3391 3165 3230 3010 4332 4305 3538 3892 M11565 GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 59/95 Gene Ontology BP GO:0051196 4.08109902245774e-07 7.70046786354252e-07 4585 3506.81818181818 3539 3.7100907086547e-08 2415 1.56972012640184 1.5930102622404 1 11.5029719473149 4585 3928 3594 3087 2415 4130 3539 3414 3429 3878 2576 3893 M14826 GO_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_SIGNALING.html A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. 20/20 Gene Ontology BP GO:0031929 1.06617943749563e-05 1.25149670097557e-05 3940 2499.09090909091 3539 9.69258731385721e-07 286 1.13142187516553 -1.18016694651315 -1 6.6054184108333 421 4007 3539 3945 3939 590 286 1642 3936 3676 1509 3894 M15331 GO_FLAVONOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVONOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. 7/29 Gene Ontology BP GO:0009812 0.000133397432600047 0.000141906322333795 4270 3143.72727272727 3540 1.33405440970404e-05 346 5.75404203130745 5.24432725546432 1 26.6749662951125 4269 3612 4549 1728 4360 3268 1100 3540 346 3167 4642 3895 M15443 GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 59/95 Gene Ontology BP GO:0051193 4.08109902245774e-07 7.70046786354252e-07 4590 3515.63636363636 3540 3.7100907086547e-08 2416 1.56972012640184 1.5930102622404 1 11.5029719473149 4586 3929 3595 3088 2416 4131 3540 3501 3430 3879 2577 3896 M16321 GO_GLUCOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. 33/52 Gene Ontology BP GO:0006007 9.52743820106998e-07 1.43699092219055e-06 3260 3390.45454545455 3540 8.66131120643276e-08 2365 1.78546426943703 1.69139692024598 1 12.5130605482337 3257 3971 3104 3540 3049 3743 4040 2552 2365 3714 3960 3897 M16403 GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. 22/29 Gene Ontology BP GO:0048384 3.40237126409303e-06 4.35642088382633e-06 4035 3455.90909090909 3541 3.09306956907436e-07 2271 2.48865078345792 2.00104546683626 1 16.0320157715411 4032 4240 2682 3939 3609 3222 3011 2271 3541 3275 4193 3898 M11001 GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. 19/22 Gene Ontology BP GO:0042219 5.82716026656583e-06 7.1502575739269e-06 3545 3274.63636363636 3543 5.29743245552377e-07 1660 1.47339022392713 1.34058394290251 1 9.06619956182769 3543 2166 2857 3190 3764 4292 3969 1660 3854 2916 3810 3899 M12286 GO_PEPTIDYL_LYSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_MODIFICATION.html The modification of peptidyl-lysine. 329/381 Gene Ontology BP GO:0018205 2.75702672656312e-06 3.59139007802301e-06 2450 3489 3543 2.50639107423495e-07 2326 1.25564994314005 1.38039556531379 1 8.16530994132539 2448 4631 4184 4456 3543 2510 2326 2825 4023 4568 2865 3900 M16430 GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. 68/80 Gene Ontology BP GO:0043525 3.05469519619558e-08 3.81823273091526e-07 4370 3131.72727272727 3543 2.7769956714636e-09 66 1.6442182313991 2.21217664877906 1 12.6595932807049 4366 3678 3099 3350 66 4597 3543 2707 1497 3991 3555 3901 M16611 GO_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. 25/43 Gene Ontology BP GO:0030224 1.55296276450244e-07 4.41011127682522e-07 4635 3117.54545454545 3543 1.41178443102261e-08 1325 2.77818596365885 2.81437189643787 1 21.2512514083284 4289 2601 1325 2107 1546 4634 3941 4631 3543 1636 4040 3902 M10370 GO_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_BINDING.html Any process that modulates the frequency, rate or extent of protein binding. 231/277 Gene Ontology BP GO:0043393 2.06403834053339e-07 5.01485361081046e-07 3730 3387.63636363636 3544 1.87639866743758e-08 1839 1.72849394870376 2.00918070683114 1 13.0662490446115 3728 3638 3331 3771 1839 3544 4126 3682 3447 3073 3085 3903 M10726 GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 14/24 Gene Ontology BP GO:0070168 3.2842686045877e-06 4.22263106304133e-06 3365 3193.90909090909 3544 2.98570318865114e-07 1202 1.91757630142896 1.83890041228403 1 12.3609151293951 3361 3815 2340 3544 3595 3251 3832 2064 3939 1202 4190 3904 M11263 GO_IMMUNE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. 664/940 Gene Ontology BP GO:0002520 7.2417524999518e-08 4.02645553947883e-07 4355 2878.72727272727 3544 7.24175273594522e-09 572 1.97622400722376 2.26195131098727 1 15.1815326477821 4354 1406 4290 1758 727 3894 4181 4174 2766 572 3544 3905 M14459 GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. 74/106 Gene Ontology BP GO:0046888 1.66724666389499e-07 4.53963284590687e-07 3830 3167.36363636364 3545 1.5156789002232e-08 1623 2.0737405575502 -2.08746916349719 -1 15.8050839987103 3826 4154 1916 3947 1623 4381 3790 2882 3545 2353 2424 3906 M15519 GO_CELLULAR_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. 15/17 Gene Ontology BP GO:0006878 1.58048838492723e-06 2.19130287695661e-06 3505 3625.54545454545 3545 1.43680865487023e-07 2751 1.28602410744675 -0.913201882521756 -1 8.69902775153136 3505 4057 3538 3545 3324 3246 2751 3809 3814 3796 4496 3907 M15172 GO_ESTROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 9/23 Gene Ontology BP GO:0006703 2.51266823082641e-06 3.29800995149091e-06 2185 3076.81818181818 3546 2.51267107190667e-07 718 1.08904476342885 -0.868268946604531 -1 7.11698589614311 2181 3858 4539 4181 3546 2406 2239 718 4099 3875 2203 3908 M15868 GO_DNA_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. 17/17 Gene Ontology BP GO:0006266 6.37386049871685e-06 7.73945013061835e-06 975 2288.72727272727 3546 5.79443542290889e-07 148 1.05267683127814 1.13990063848269 1 6.40424868103932 973 4046 3659 3546 3840 403 148 210 3638 4119 594 3909 M16203 GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 28/38 Gene Ontology BP GO:0071549 0.00691683414403681 0.0070286152592713 2690 3272.54545454545 3546 0.000630788816593145 1064 1.28943456324771 1.22806024313048 1 3.25471687807015 2687 4480 3546 4388 4594 2261 1064 1960 4353 3961 2704 3910 M16796 GO_SPLEEN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLEEN_DEVELOPMENT.html The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. 37/48 Gene Ontology BP GO:0048536 5.02490853882172e-06 6.24489835233372e-06 2530 3339.36363636364 3546 4.5681091054522e-07 1725 1.3939836925451 -1.18166645344435 -1 8.671162781852 2527 4451 3599 4178 3720 2888 1725 2987 3647 3546 3465 3911 M15428 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter. 19/20 Gene Ontology BP GO:0045943 1.22705217031152e-05 1.42987071085887e-05 4210 3283.81818181818 3548 1.11550819478231e-06 424 1.96798091455552 1.02785231182443 1 11.4277793151185 4209 3548 2993 3509 3966 4585 4613 2156 424 3574 2545 3912 M12703 GO_CELLULAR_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. 71/154 Gene Ontology BP GO:0034754 1.52837779869527e-07 4.38984067736363e-07 4245 3234 3549 1.38943445897665e-08 1525 2.09459650307763 2.11697423143514 1 16.0019874675143 4245 1879 1784 4464 1525 4241 4179 3051 3549 2326 4331 3913 M13351 GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY.html A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. 10/24 Gene Ontology BP GO:0007597 4.9862673040352e-05 5.47066771178396e-05 1530 3179 3549 4.53307301875338e-06 1086 1.70743927796155 1.70743927796155 1 8.6978718060754 1527 4322 2923 4357 4215 1468 1086 3549 4519 3966 3037 3914 M15703 GO_ZINC_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. 19/27 Gene Ontology BP GO:0055069 1.08549408653435e-06 1.5893027012726e-06 4100 3142.18181818182 3550 9.86813292840409e-08 556 2.78518266118656 -2.93305872995671 -1 19.4296543693533 3982 3550 2049 2688 3144 4368 4099 4100 556 2117 3911 3915 M10661 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. 5/23 Gene Ontology BP GO:0051818 0.000917208333206164 0.000946710375866966 3070 3641.54545454545 3553 9.17587125271384e-05 2932 3.32469269397061 -3.32469269397061 -1 12.0552936298669 3070 4333 4254 3949 4492 3929 2992 3240 2932 3313 3553 3916 M13290 GO_REGULATION_OF_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of fatty acid transport. 33/57 Gene Ontology BP GO:2000191 3.7138570546666e-07 7.18527105004727e-07 4105 3546.45454545455 3554 3.37623425600837e-08 2351 1.56196741438759 -1.37130613302076 -1 11.5024621485446 4102 2556 2648 4507 2351 4094 3554 3534 4496 2657 4512 3917 M15234 GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. 5/23 Gene Ontology BP GO:0051883 0.000917208333206164 0.000946710375866966 3075 3668.81818181818 3554 9.17587125271384e-05 2933 3.32469269397061 -3.32469269397061 -1 12.0552936298669 3071 4334 4544 3950 4493 3930 2993 3238 2933 3317 3554 3918 M12606 GO_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR.html The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 499/574 Gene Ontology BP GO:0006281 2.85418823877123e-06 3.70550721958776e-06 910 2885.63636363636 3558 2.5947199469843e-07 446 1.23879060011276 1.36888339106329 1 8.0339406404055 909 4617 4201 4454 3558 446 705 2327 3926 4562 2037 3919 M13681 GO_ACROSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_ASSEMBLY.html The formation of the acrosome from the spermatid Golgi. 12/18 Gene Ontology BP GO:0001675 0.00115239997832452 0.001185784409364 3175 3614.45454545455 3558 0.000104818551766221 3045 1.08585414103398 -0.848575701785419 -1 3.73954304980336 3172 3379 3558 3066 4501 3333 3045 3729 3877 3827 4272 3920 M15857 GO_2_OXOGLUTARATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_OXOGLUTARATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. 19/25 Gene Ontology BP GO:0006103 3.34143465210729e-05 3.71776552755983e-05 3560 3627.54545454545 3558 3.03771400366346e-06 2927 0.979215160996165 0.83892079343327 1 5.14298098741249 3558 3319 3820 3098 4159 2927 3213 4306 4174 3837 3492 3921 M10727 GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. 10/15 Gene Ontology BP GO:0045779 0.000147948409715332 0.000157026448541387 3560 3373.54545454545 3559 1.34507600068881e-05 1252 2.67805601586427 2.72465803224728 1 12.2176541492873 3559 1252 1999 3893 4362 3944 3320 4635 3452 2682 4011 3922 M15890 GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). 44/109 Gene Ontology BP GO:0007189 1.05296447971191e-06 1.5534063805008e-06 4280 3305.90909090909 3559 9.57240894256673e-08 1432 2.36285332015968 -2.13121867059964 -1 16.4961916365039 4280 3216 1610 3688 3117 4446 2481 4441 3559 1432 4095 3923 M15932 GO_RNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 250/362 Gene Ontology BP GO:0006401 4.89646002949024e-07 8.70982813709036e-07 4645 3433 3559 4.45132829025263e-08 1491 0.811089756541868 -0.760480708082774 -1 5.84146735997038 1491 4644 4214 4642 2569 2590 1611 3559 4424 4645 3374 3924 M13497 GO_PROTEIN_ADP_RIBOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ADP_RIBOSYLATION.html The transfer, from NAD, of ADP-ribose to protein amino acids. 18/22 Gene Ontology BP GO:0006471 5.0405689643791e-05 5.52503354328762e-05 4615 3536.36363636364 3560 4.58244041452021e-06 591 1.44798716697397 1.68380387319435 1 7.35303050980525 4613 3560 3299 3256 4218 3978 3337 4467 591 3453 4128 3925 M16439 GO_DOPAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_TRANSPORT.html The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 6/13 Gene Ontology BP GO:0015872 2.61122050025447e-06 3.42061063842457e-06 4130 2958.36363636364 3560 2.61122356857218e-07 324 3.0874782998874 3.59139775852207 1 20.3066338808158 4126 2307 4622 1107 3560 4115 4165 3062 324 1521 3633 3926 M15561 GO_PEPTIDYL_LYSINE_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_TRIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. 26/28 Gene Ontology BP GO:0018023 2.09949077620623e-05 2.37455774955945e-05 1040 3090.45454545455 3562 1.90864619291645e-06 1036 1.19378335001395 -1.22093555859598 -1 6.57358351893525 1036 4001 3562 4526 4092 1679 1130 3299 4450 3662 2558 3927 M15644 GO_GTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GTP, guanosine triphosphate. 25/28 Gene Ontology BP GO:0046039 6.7983671909792e-08 4.02645553947883e-07 3610 3081.63636363636 3562 6.18033400096374e-09 532 1.45508151825326 1.82235454340633 1 11.1509180185125 3607 2068 2769 4116 532 3628 3849 3272 2280 3562 4215 3928 M15928 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 18/27 Gene Ontology BP GO:0030949 8.23298845751408e-05 8.86761465111413e-05 2210 3058 3562 7.48481506736973e-06 1565 1.6906730715778 1.64559273483652 1 8.18254345387494 2208 3787 2435 3761 4293 1766 1565 3825 4478 1958 3562 3929 M11958 GO_MITOTIC_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_ARREST.html The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M). 17/18 Gene Ontology BP GO:0071850 6.19147785854232e-06 7.54358378523106e-06 3340 3421.63636363636 3563 5.62863207576124e-07 772 1.82494427458395 -1.67178400793244 -1 11.2026520826252 3336 4043 2943 3486 3791 3908 4502 772 3563 3374 3920 3930 M10603 GO_MICROTUBULE_ANCHORING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ANCHORING.html Any process in which a microtubule is maintained in a specific location in a cell. 22/22 Gene Ontology BP GO:0034453 1.47873491932029e-06 2.06871725183322e-06 4445 3392.18181818182 3565 1.34430537568746e-07 706 1.52392518260096 -1.13197137613453 -1 10.373381591103 4441 2625 3218 4469 3294 4281 4076 2219 706 3565 4420 3931 M11071 GO_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH.html Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). 1128/1569 Gene Ontology BP GO:0008219 6.16542413372474e-08 4.02645553947883e-07 3965 2852.45454545455 3566 6.16542430478078e-09 530 1.93099669314076 -1.81008751961766 -1 14.8317360419716 3963 1336 4277 1903 530 4456 3566 4567 1971 1148 3660 3932 M12571 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. 32/32 Gene Ontology BP GO:0006359 1.72038204047875e-05 1.96391992991846e-05 4050 3303.72727272727 3566 1.56399590352105e-06 770 1.98743626526447 -1.54435589212726 -1 11.210490532685 3014 3725 2741 3566 4048 3553 4050 4481 770 3988 2405 3933 M12788 GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. 22/24 Gene Ontology BP GO:1903671 4.37094698956916e-06 5.48748610999338e-06 3760 3523.36363636364 3566 3.97359606705904e-07 2396 1.34290576393803 1.29452500534909 1 8.44086085033489 3758 2983 3077 3064 3682 3504 3810 4332 2396 3566 4585 3934 M11436 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 24/31 Gene Ontology BP GO:0010804 0.00280392437776396 0.00286928967005403 1325 2948.90909090909 3568 0.000255227672724819 634 1.15921858748724 -1.12827353235869 -1 3.46113033251441 1324 3759 3568 3973 4528 1355 634 2377 4387 4102 2431 3935 M12390 GO_REGULATION_OF_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEEDING_BEHAVIOR.html Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. 14/30 Gene Ontology BP GO:0060259 0.00215223749166574 0.00220580639839663 3570 3212.27272727273 3568 0.000195849626529694 701 2.17058294782688 -2.13691672021923 -1 6.87043612846386 3568 4296 2479 3765 4522 2414 701 2781 3573 2968 4268 3936 M15037 GO_ORGANELLE_INHERITANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INHERITANCE.html The partitioning of organelles between daughter cells at cell division. 16/16 Gene Ontology BP GO:0048308 1.30759925952603e-06 1.85949246777952e-06 4470 3618.90909090909 3568 1.18872730610517e-07 2955 1.05973880669932 -0.788167139278172 -1 7.24164588147485 4467 3568 3657 3559 3239 3881 3331 3074 2955 4076 4001 3937 M14864 GO_ERROR_PRONE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_PRONE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 21/25 Gene Ontology BP GO:0042276 1.5640330363199e-05 1.79778797381336e-05 4025 3303.36363636364 3569 1.42185832319861e-06 1401 1.0771875321225 1.21585370968354 1 6.07892092499848 2504 4025 3569 3997 4021 2259 1401 2731 4427 3950 3453 3938 M14044 GO_REGULATION_OF_MITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOPHAGY.html Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy). 56/62 Gene Ontology BP GO:1903146 2.42945301203359e-06 3.20052232870676e-06 4220 3689.63636363636 3570 2.20859608624998e-07 2808 0.997183072930712 0.815275287262558 1 6.52369395970447 4216 4421 4052 3122 3498 3570 3135 2808 3923 4319 3522 3939 M16265 GO_RESPONSE_TO_MISFOLDED_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MISFOLDED_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. 16/17 Gene Ontology BP GO:0051788 0.000196884030106176 0.000207826994574418 3940 2974.54545454545 3570 1.79001501823241e-05 174 1.7715966170183 -2.57040112246819 -1 7.78660230733894 3940 4552 3570 3067 4389 3793 2099 2174 174 4077 885 3940 M12608 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. 21/24 Gene Ontology BP GO:0048009 3.23062981738579e-06 4.15826294337374e-06 2675 3409.63636363636 3571 2.93694051042943e-07 2529 1.1146794323792 -1.27912846229361 -1 7.15123503702505 2675 3540 3571 3576 3591 2839 3636 2529 4339 3943 3267 3941 M11085 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 458/605 Gene Ontology BP GO:1903829 9.4156503636354e-08 4.02645553947883e-07 3955 3023 3573 8.55968251510026e-09 930 1.8006170969316 1.92163535063584 1 13.8233555722137 3953 1489 3062 1878 930 3573 4326 4605 1584 3681 4172 3942 M13757 GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR.html The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. 19/22 Gene Ontology BP GO:0042994 1.10249894205451e-05 1.29119747731679e-05 1800 2934.27272727273 3573 1.00227678828279e-06 1420 1.17866943688938 -1.33511819022646 -1 6.86622282670585 1797 3785 3597 3573 3951 2092 1420 1601 3857 3835 2769 3943 M15179 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 17/18 Gene Ontology BP GO:0045717 3.53972137864417e-05 3.92589508951745e-05 2840 3611.72727272727 3574 3.21798030252644e-06 2582 0.774377184017455 -0.62783615641562 -1 4.02344951325669 2838 3574 3866 4540 4171 2713 2582 3420 4559 4118 3348 3944 M10847 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. 14/15 Gene Ontology BP GO:0043923 8.81268855345428e-07 1.35331484617897e-06 4415 3732.72727272727 3575 8.01153825783129e-08 2987 1.05980323500368 -1.0394416067728 -1 7.41896454206627 4415 3575 3581 3523 2987 4191 3491 3282 4446 3355 4214 3945 M11737 GO_SINGLE_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves only one organism. 109/124 Gene Ontology BP GO:1902591 5.03759538688091e-07 8.8989868394673e-07 3325 3552.09090909091 3575 4.57963321854361e-08 2436 1.7990754932247 -1.28278284070184 -1 13.0620495723041 3323 4370 3314 3826 2587 3575 2762 4515 2436 4124 4241 3946 M11463 GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL.html The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. 1776/2289 Gene Ontology BP GO:0051649 9.50679749923149e-08 4.02645553947883e-07 3295 3482.90909090909 3577 9.5067979059379e-09 1072 1.53164005348453 -1.36778296428552 -1 11.7430362177179 3294 4109 4303 4414 1072 3577 3264 3725 2471 4557 3526 3947 M11444 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. 198/266 Gene Ontology BP GO:0048002 4.65904865208597e-07 8.43851824762788e-07 3580 3392.54545454545 3578 4.23549967159637e-08 2518 1.4834787875642 -1.38116861247026 -1 10.7940209665063 3578 2792 3718 2540 2518 4065 3963 4293 2595 3407 3849 3948 M12625 GO_COBALAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COBALAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. 19/42 Gene Ontology BP GO:0009235 5.89650658200133e-07 1.00169569646047e-06 4050 3363.90909090909 3578 5.36046196581951e-08 1006 1.50690648480578 -1.88863905569396 -1 10.8303934130062 4046 1006 2880 4308 2697 3831 3448 4352 3578 2919 3938 3949 M13300 GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 953/1400 Gene Ontology BP GO:0014070 8.73072759926481e-13 3.07758147874084e-11 4215 2711.81818181818 3578 8.73072759926824e-14 83 2.21457144957497 2.26394698298722 1 28.0507371606543 4213 1350 4420 358 666 3578 3952 4544 2211 83 4455 3950 M13928 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 24/28 Gene Ontology BP GO:0010592 3.13917143004922e-05 3.49857836263929e-05 3680 3600 3578 2.853832930599e-06 2736 1.30998403656192 -1.01787949807072 -1 6.95681556892433 3679 3757 3524 3313 4151 3390 2736 3578 3307 3926 4239 3951 M14771 GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a steroid hormone binding to a receptor. 122/224 Gene Ontology BP GO:0043401 3.84223172976894e-07 7.37233164478964e-07 3820 3459.18181818182 3579 3.49293854618451e-08 2376 1.67844611696536 1.75680286179331 1 12.3452418186751 3817 3162 3472 3730 2376 3579 3653 4030 3065 3785 3382 3952 M14980 GO_VACUOLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_FUSION.html Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. 24/25 Gene Ontology BP GO:0097576 0.00212234061518981 0.00217612403756681 795 2923.27272727273 3579 0.000193126437023528 675 1.00307222893597 -0.883429921221219 -1 3.12673248020792 791 3998 3878 3579 4520 1006 675 3100 3695 4222 2692 3953 M13159 GO_CARNITINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARNITINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. 14/16 Gene Ontology BP GO:0009437 6.6130725235872e-07 1.08691721837694e-06 4010 3638 3580 6.01188591949029e-08 2786 1.51610562933259 -1.67233268967611 -1 10.8321180027235 4008 3580 3208 3725 2786 3548 3506 3813 4045 3362 4437 3954 M14819 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. 55/70 Gene Ontology BP GO:1903201 1.04796560292677e-07 4.02645553947883e-07 3575 3426.72727272727 3580 9.5269604804219e-09 1073 1.34430810866413 1.59065641472735 1 10.2941755062948 3572 3204 3580 3343 1073 4171 4520 2961 3594 3745 3931 3955 M10813 GO_COENZYME_A_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 17/17 Gene Ontology BP GO:0015936 9.15077424478376e-07 1.39675472105227e-06 4295 3691.90909090909 3581 8.31888913727109e-08 3010 1.05212065096498 1.07421323386118 1 7.34697820505643 4292 3562 3634 4495 3010 3581 4055 3343 4132 3371 3136 3956 M13951 GO_INTERSTRAND_CROSS_LINK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTRAND_CROSS_LINK_REPAIR.html Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. 45/49 Gene Ontology BP GO:0036297 3.03752076250998e-06 3.91946314696588e-06 1740 3202.09090909091 3581 2.76138632399677e-07 1122 1.05603195176108 1.09199512952296 1 6.80236902219523 1740 4444 3989 4397 3581 1506 1122 2916 4351 4326 2851 3957 M16135 GO_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOCLAST_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. 44/50 Gene Ontology BP GO:0030316 9.03527973504215e-08 4.02645553947883e-07 3870 2886.90909090909 3581 8.21389100556013e-09 887 2.1976488545818 1.92970907027719 1 16.8940743190784 3866 1945 1622 2301 887 4088 3883 3581 3845 1674 4064 3958 M10838 GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). 15/33 Gene Ontology BP GO:0042744 0.0211301321109272 0.0213457457038959 1795 3197.90909090909 3582 0.00193962274962651 1209 1.30838694410129 -1.25597831116127 -1 2.54067260888842 1791 3809 3192 3731 4620 2341 1209 2370 4509 4023 3582 3959 M12072 GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. 43/57 Gene Ontology BP GO:0031057 2.68985677830585e-06 3.50880392191117e-06 2955 3615.36363636364 3583 2.4453273337251e-07 2429 1.01399826789181 1.13440531442499 1 6.58645984105063 2952 3951 4038 4263 3537 3329 3583 3297 4109 4281 2429 3960 M13895 GO_SPERMATID_NUCLEUS_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_NUCLEUS_DIFFERENTIATION.html The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. 26/134 Gene Ontology BP GO:0007289 7.17841151357945e-07 1.15136672777267e-06 3665 3593.63636363636 3583 6.52583077803155e-08 2859 1.38242851076598 1.56763036947868 1 9.82613092774009 3661 3527 3500 3583 2859 3896 3277 4392 3799 3119 3917 3961 M14908 GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of cellular protein catabolic process. 315/354 Gene Ontology BP GO:1903362 1.49173089738434e-07 4.36901586057683e-07 4105 3410.18181818182 3584 1.35611908957507e-08 1488 1.36731936583193 1.4838268488416 1 10.4135099390167 3584 3631 4104 3119 1488 2976 3259 4223 2560 4464 4104 3962 M13033 GO_RESPONSE_TO_PROTOZOAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROTOZOAN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. 15/25 Gene Ontology BP GO:0001562 3.86649510144424e-05 4.27233476775589e-05 3345 3673.81818181818 3586 3.515057324256e-06 2885 1.37530649512096 -1.20920967451797 -1 7.16452177944575 3342 3586 3260 3793 4178 3891 3399 2885 4449 3470 4159 3963 M16038 GO_PEPTIDYL_ARGININE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_METHYLATION.html The addition of a methyl group to an arginine residue in a protein. 11/14 Gene Ontology BP GO:0018216 0.0001232210772515 0.000131200840377856 1730 3066.09090909091 3586 1.1202543577598e-05 1073 0.832691154619829 0.885290150209363 1 3.8064914801981 1730 3601 3737 3586 4345 1914 1073 2273 4468 4034 2966 3964 M10564 GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 15/17 Gene Ontology BP GO:0046130 3.8666014427464e-06 4.89425911672987e-06 3515 3480.18181818182 3588 3.51509839863041e-07 2663 1.74769764538483 1.8106650237703 1 11.1212431743561 3513 3802 2749 4126 3649 3588 3364 3644 3445 2663 3739 3965 M11286 GO_PROTEIN_NEDDYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_NEDDYLATION.html Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. 14/16 Gene Ontology BP GO:0045116 0.000245295678612543 0.000257876365247212 1630 3005.90909090909 3588 2.23020938971728e-05 1050 1.00211377956495 0.940888969657967 1 4.24624541096185 1626 3588 3680 3785 4407 2043 1050 2412 4052 3715 2707 3966 M16383 GO_RECEPTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 19/24 Gene Ontology BP GO:0032801 2.04140854501892e-05 2.31055070785041e-05 3620 3326.63636363636 3588 1.8558431706907e-06 1166 1.6909797507854 -2.35707966732828 -1 9.37855191849708 3616 4256 3489 3588 4088 3017 2298 3883 1166 4193 2999 3967 M14480 GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 15/17 Gene Ontology BP GO:0006152 3.8666014427464e-06 4.89425911672987e-06 3515 3487.90909090909 3589 3.51509839863041e-07 2674 1.74769764538483 1.8106650237703 1 11.1212431743561 3514 3803 2750 4127 3650 3589 3365 3709 3446 2674 3740 3968 M10244 GO_REGULATION_OF_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULOGENESIS.html Any process that modulates the frequency, rate or extent of vasculogenesis. 16/21 Gene Ontology BP GO:2001212 4.24971859598104e-07 7.94453219248685e-07 3915 3359.27272727273 3591 3.8633812880866e-08 2334 2.02801158293749 1.49335130244464 1 14.8581727015095 3911 3805 2334 4136 2441 4385 3056 3172 3712 2409 3591 3969 M10408 GO_AXO_DENDRITIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXO_DENDRITIC_TRANSPORT.html The directed movement of organelles or molecules along microtubules in neuron projections. 39/46 Gene Ontology BP GO:0008088 1.91634229381139e-05 2.17428448990597e-05 3405 3468.54545454545 3591 1.74214453326891e-06 1807 1.37932903843711 -0.758581611667595 -1 7.67512994771692 3404 3959 3509 3591 4077 2267 1807 3976 3153 4109 4302 3970 M12479 GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. 41/76 Gene Ontology BP GO:0032651 3.23775508869708e-06 4.16628164483062e-06 4095 3341.72727272727 3592 2.94341804884843e-07 1887 1.77451056687029 -1.90956948447464 -1 11.4435370657881 4093 2892 2051 2790 3592 3616 2953 4424 4241 1887 4220 3971 M12774 GO_PIGMENT_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. 42/55 Gene Ontology BP GO:0046148 1.78735038601615e-07 4.70925331038116e-07 3585 3412.18181818182 3593 1.62486411929657e-08 1239 1.27270231498424 0.895784448124307 1 9.63565209907069 3582 2521 3593 4467 1684 4614 4478 3452 1239 4184 3720 3972 M16742 GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus. 16/18 Gene Ontology BP GO:2001275 1.40695200648267e-07 4.27878933736202e-07 3950 3462.18181818182 3593 1.27904736041872e-08 1429 1.52542507416292 -2.01450075941227 -1 11.6462681780592 3948 4054 3102 4217 1429 3186 3067 3508 3920 3593 4060 3973 M11802 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 1695/2327 Gene Ontology BP GO:0010628 1.3128851128127e-07 4.19475731204347e-07 3570 3465.09090909091 3597 1.31288519037773e-08 1461 1.82126717397398 1.94469436225614 1 13.943895653069 3566 3401 4325 3901 1461 3343 4410 3620 2852 3597 3640 3974 M10698 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 12/14 Gene Ontology BP GO:0034244 0.00675550349386508 0.00686767702795591 2230 3542.81818181818 3599 0.000616030647674785 2226 0.643536559120561 -0.687086832434754 -1 1.58063448975402 2226 3599 3841 4026 4559 2552 2964 2866 4611 4596 3131 3975 M11986 GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 34/36 Gene Ontology BP GO:0051973 2.65957721314335e-05 2.97977673314616e-05 4040 3312.54545454545 3599 2.41782669571159e-06 369 1.68531577710941 1.60194044651724 1 9.12163525282983 4036 4459 3253 2616 4129 2701 2784 3599 369 4063 4429 3976 M12920 GO_APOPTOTIC_NUCLEAR_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_NUCLEAR_CHANGES.html Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. 26/32 Gene Ontology BP GO:0030262 5.32691636179799e-05 5.8142486116458e-05 3515 3712.36363636364 3600 4.84276849832821e-06 2915 1.32143835259613 -1.40442253997282 -1 6.66599147682097 3299 3531 3600 3511 4235 4353 4528 3512 2915 3660 3692 3977 M14758 GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. 35/55 Gene Ontology BP GO:0060338 0.000227382289756996 0.000239422899805228 955 2962.09090909091 3601 2.06732540352724e-05 806 1.6976855890674 -1.7162394970283 -1 7.33125390277871 955 4463 3601 4255 4401 1553 806 3314 3768 3971 1496 3978 M16023 GO_RNA_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_LOCALIZATION.html A process in which RNA is transported to, or maintained in, a specific location. 190/248 Gene Ontology BP GO:0006403 1.2554902717083e-05 1.46122117259589e-05 1450 3250.63636363636 3601 1.14136130596794e-06 1181 1.03804633171689 0.862033609374025 1 5.96730843621506 1450 4356 4216 3123 3970 2002 1181 3429 3850 4579 3601 3979 M10557 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. 13/24 Gene Ontology BP GO:0032692 7.48228348933947e-05 8.07961593778059e-05 3715 3626.54545454545 3603 6.80230725159803e-06 2947 1.47190206479199 -1.99919966194444 -1 7.18235510233245 3715 3367 2947 3268 4280 4181 4086 3397 3359 3603 3689 3980 M13298 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING.html Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. 26/30 Gene Ontology BP GO:0006297 3.31352017600247e-05 3.68758894497476e-05 1440 3123.09090909091 3603 3.01233643953727e-06 1346 0.99466040952384 1.16587176222797 1 5.22998344531621 1438 3755 3773 3603 4158 2055 1346 2648 4438 4021 3119 3981 M14111 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein. 31/58 Gene Ontology BP GO:0042517 5.42503316105587e-06 6.69567090143049e-06 3605 3055.09090909091 3603 4.93186048983856e-07 1736 2.25528670658684 2.10960589184696 1 14.0098841126253 3603 3728 1992 2807 3745 4199 3603 1829 3610 2754 1736 3982 M14756 GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. 14/14 Gene Ontology BP GO:0046341 3.3501233314377e-06 4.29690742422028e-06 3900 3510.81818181818 3603 3.04557130269141e-07 2438 1.41291648549907 1.5612928808848 1 9.06778416816394 3900 3814 3259 3905 3603 2831 2773 4372 2438 3363 4361 3983 M15420 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. 13/16 Gene Ontology BP GO:1903203 0.287487901968055 0.288231244959569 4115 3672.45454545455 3604 0.0303444744382064 2354 0.920313149954634 0.90623469721665 1 0.498363519691937 4114 3827 3604 3332 4641 3242 2354 3354 4388 3216 4325 3984 M14569 GO_REGULATION_OF_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_ORGANIZATION.html Any process that modulates the frequency, rate or extent of chromatin organization. 180/225 Gene Ontology BP GO:1902275 1.87971170171003e-06 2.55291843200723e-06 3605 3468.27272727273 3605 1.70883027978611e-07 2154 1.677569386933 1.85959376254283 1 11.2443138842847 3605 3647 3672 2154 3395 4009 4421 2926 3047 3932 3343 3985 M16219 GO_SINGLE_ORGANISM_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CATABOLIC_PROCESS.html A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism. 868/1233 Gene Ontology BP GO:0044712 1.17801620543224e-07 4.08807542125352e-07 3395 3087.45454545455 3605 1.17801626787974e-08 1333 1.98302206683476 -1.82675303247585 -1 15.2182912137698 3392 1376 4605 3648 1333 3876 3774 3854 2792 1707 3605 3986 M16953 GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 234/317 Gene Ontology BP GO:0000302 4.99734053707137e-07 8.86239395563079e-07 3605 3532.63636363636 3605 4.54303788384259e-08 2167 1.87754140927201 2.01723220109517 1 13.6402992312353 4652 3637 2167 3602 2576 4533 3605 4348 3531 2393 3815 3987 M12301 GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 41/74 Gene Ontology BP GO:0070286 2.44442598279741e-07 5.53132660470759e-07 4620 3185.36363636364 3606 2.22220568581663e-08 1495 2.50398073538994 2.30136802737823 1 18.8456800648536 4617 3949 1890 4131 1992 3899 4554 1495 2204 2702 3606 3988 M14363 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 12/12 Gene Ontology BP GO:1900102 0.000161936353621885 0.00017167688617057 1505 2707 3606 1.47225704154306e-05 129 1.02225527165951 -1.20736745149576 -1 4.55211619569655 1503 4303 3736 3606 4369 1151 129 2040 4404 4091 445 3989 M14299 GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. 16/22 Gene Ontology BP GO:0006577 2.35030369365641e-07 5.3972042302237e-07 4160 3536 3607 2.13663994976732e-08 1962 1.39638985118591 -1.59282739993483 -1 10.4820938585453 4160 3337 3273 3904 1962 3607 2988 4532 4142 3238 3753 3990 M10234 GO_NUCLEOTIDE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. 52/76 Gene Ontology BP GO:0046939 1.11901900712055e-06 1.63018016284657e-06 2370 3267.09090909091 3608 1.01729052391308e-07 2334 1.38629831732085 1.27976067764207 1 9.60072406575541 2368 3935 3608 3752 3163 2683 2334 3713 2487 4099 3796 3991 M12355 GO_ATRIAL_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_DEVELOPMENT.html The progression of the atrial septum over time, from its initial formation to the mature structure. 19/26 Gene Ontology BP GO:0003283 7.2309819106035e-08 4.02645553947883e-07 3875 3196.63636363636 3608 6.57362013479288e-09 603 1.88805070132264 -2.02347799663121 -1 14.4995836142688 3874 3779 2490 4176 603 4465 3608 4241 2468 2112 3347 3992 M14401 GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. 40/71 Gene Ontology BP GO:0042304 8.56997141316117e-05 9.22630194017559e-05 1150 2589.54545454545 3608 7.79118660872357e-06 606 1.42964944102708 -1.32326577373298 -1 6.8735668048527 1150 4195 3691 3608 4490 1326 1006 606 3787 3761 865 3993 M10990 GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. 6/12 Gene Ontology BP GO:0090220 0.00029670084812319 0.000310445029529391 3120 3607.81818181818 3609 2.96740469695677e-05 2021 0.559200558328786 0.4183999033845 1 2.26949774723461 3119 4332 4273 3609 4429 3026 2399 2021 4487 4598 3393 3994 M14060 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. 14/15 Gene Ontology BP GO:0044794 9.30455818630488e-06 1.10275367399074e-05 2830 3579.27272727273 3609 8.45872503520099e-07 2826 1.63485013319174 1.49014392530584 1 9.69897141751218 2826 4064 3243 3487 3898 3595 3030 3857 4043 3720 3609 3995 M14395 GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. 9/11 Gene Ontology BP GO:0045741 0.00240279589862134 0.00246043338826696 3290 3667.45454545455 3610 0.000240539790180557 1946 1.91963703676602 2.58116214032349 1 5.9540798959151 3289 3610 4490 4492 4526 3563 3977 1946 3933 3031 3485 3996 M12698 GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 291/381 Gene Ontology BP GO:0046822 1.25771248201112e-07 4.15930076673615e-07 3990 3187.63636363636 3612 1.1433750490118e-08 1186 1.98183439750677 2.03686336943345 1 15.1911354199718 3986 3415 2683 1451 1299 3657 4587 4560 1186 3612 4628 3997 M14187 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE.html The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. 14/15 Gene Ontology BP GO:1990126 1.99347202981557e-06 2.6909269958607e-06 3590 3640.81818181818 3613 1.81224894195455e-07 2331 0.80874910708245 -0.822859581974217 -1 5.3451496810061 3589 4085 3865 3613 3415 3146 3597 3722 4518 4168 2331 3998 M15869 GO_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of sprouting angiogenesis. 36/46 Gene Ontology BP GO:1903670 2.74602720346353e-05 3.0714691529841e-05 3615 3650.09090909091 3613 2.49641952710394e-06 3100 1.41905242316179 1.5424881480335 1 7.64165073141087 3613 3958 3123 3100 4135 3348 3386 3961 3634 3511 4382 3999 M15990 GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. 111/167 Gene Ontology BP GO:0072593 8.0753072989418e-08 4.02645553947883e-07 4200 3019.18181818182 3613 7.34118872304872e-09 745 2.04644090517148 1.98181775532688 1 15.7246034241625 4199 2830 1455 3874 745 3777 4234 2864 3613 1898 3722 4000 M14055 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 27/31 Gene Ontology BP GO:2001267 1.94338223065155e-07 4.92245918302759e-07 3370 3542.63636363636 3614 1.76671127483757e-08 1756 1.74593344196259 -1.54921654021429 -1 13.2161716234465 3614 4484 3370 4554 1756 3655 3369 2725 4148 3731 3563 4001 M15333 GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. 13/14 Gene Ontology BP GO:0006047 5.66479172342447e-05 6.17434431695808e-05 1235 2742 3614 5.14994326518801e-06 535 1.25284287974928 -1.36344067106532 -1 6.27507517521999 1234 4308 3614 4198 4567 1171 889 535 4226 3901 1519 4002 M10884 GO_SNORNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. 10/12 Gene Ontology BP GO:0016074 0.000617096523743768 0.000639498914249388 1810 3270.63636363636 3615 5.61154260316347e-05 865 0.836728605608411 0.856156365326068 1 3.12933220257521 1808 4104 3615 4360 4467 2104 865 2868 4562 4211 3013 4003 M13892 GO_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BIOSYNTHETIC_PROCESS.html The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 121/137 Gene Ontology BP GO:0071897 6.36632946178545e-06 7.73232341051624e-06 480 2615.09090909091 3616 5.78758898605082e-07 480 1.33505171084698 1.44385925387852 1 8.15041770320143 480 3900 4036 3616 3803 489 582 1988 3976 3987 1909 4004 M15572 GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION.html Any process that modulates the frequency, rate or extent of cytoplasmic translation. 17/17 Gene Ontology BP GO:2000765 3.9242453869242e-07 7.49790548085187e-07 4480 3521.45454545455 3616 3.56749644264621e-08 1083 1.29130311510363 1.43250732693681 1 9.46253961335157 4479 1083 3269 4474 2386 3867 3464 4502 3616 3016 4580 4005 M10050 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. 47/50 Gene Ontology BP GO:0048008 1.05354308629202e-06 1.55366773681715e-06 3150 3533.54545454545 3618 9.5776690074224e-08 2708 1.45716990008537 1.6604698938555 1 10.133596658728 3148 3692 3319 4190 3118 3699 3894 2708 4108 3618 3375 4006 M11104 GO_ATP_GENERATION_FROM_ADP http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_GENERATION_FROM_ADP.html The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. 34/54 Gene Ontology BP GO:0006757 2.15218519528084e-05 2.43061109554411e-05 3565 3774.54545454545 3618 1.95655113605925e-06 2883 1.29074648786109 0.879766303296976 1 7.10005741459208 3561 4216 3755 3581 4098 3618 2883 3439 3550 4267 4552 4007 M11558 GO_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SENESCENCE.html A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. 47/66 Gene Ontology BP GO:0090398 9.34669700852711e-06 1.10718383861193e-05 3725 2670.09090909091 3619 8.4970333801753e-07 249 2.33221362830836 3.1148431052809 1 13.8751820194138 3724 3937 2137 1436 3901 4051 4640 249 497 3619 1180 4008 M11674 GO_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPAIR.html Any process that modulates the frequency, rate or extent of DNA repair. 90/109 Gene Ontology BP GO:0006282 7.3171671820107e-07 1.16999240198955e-06 3995 3615 3619 6.65197237790065e-08 2867 1.47049704845104 1.49579600623008 1 10.4462757731812 3992 3910 3619 4027 2867 3245 3032 3949 3509 3543 4072 4009 M16581 GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 137/177 Gene Ontology BP GO:0034614 9.38128463316232e-07 1.42325130088374e-06 4240 3682.72727272727 3619 8.52844421231921e-08 3029 1.7388251385821 1.8767661744961 1 12.1922846762451 4236 3895 3117 3619 3029 4402 4601 3366 3779 3334 3132 4010 M10148 GO_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_FIBER_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. 21/22 Gene Ontology BP GO:0043149 0.0286304017568824 0.0288849218071929 4065 3624.27272727273 3621 0.00263726596115215 1988 1.60643915512577 -1.85669303733829 -1 2.8876859813878 4064 4241 3296 3287 4595 3859 3621 3476 1988 3436 4004 4011 M15461 GO_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECOMBINATIONAL_REPAIR.html A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. 76/92 Gene Ontology BP GO:0000725 2.69166080495567e-05 3.01282119929245e-05 430 2619.09090909091 3621 2.44699430682742e-06 235 1.19523808014976 1.28117211541428 1 6.43226649186841 428 3914 4039 3621 4133 519 235 1874 4160 3734 2153 4012 M11075 GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. 21/22 Gene Ontology BP GO:0030038 0.0286304017568824 0.0288849218071929 4065 3635.09090909091 3622 0.00263726596115215 1989 1.60643915512577 -1.85669303733829 -1 2.8876859813878 4065 4242 3297 3288 4596 3860 3622 3583 1989 3439 4005 4013 M13931 GO_REGULATION_OF_PROTEIN_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_STABILITY.html Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. 252/304 Gene Ontology BP GO:0031647 6.46630436754296e-07 1.07226351468915e-06 3625 3530.63636363636 3623 5.87846024376259e-08 2348 1.64109368572837 -1.54975674634155 -1 11.7453077653091 3623 4344 3950 2348 2762 4274 4278 3049 2783 4467 2959 4014 M16313 GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. 11/18 Gene Ontology BP GO:1903209 0.00210966907409813 0.00216360815556063 1860 2867.54545454545 3623 0.000191972258303503 658 0.808643939653246 -0.808643939653246 -1 2.50316245568035 1859 4315 3693 3623 4632 1435 881 1763 4649 4035 658 4015 M11114 GO_MITOCHONDRIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSPORT.html Transport of substances into, out of or within a mitochondrion. 214/271 Gene Ontology BP GO:0006839 4.34086102737562e-07 8.05527566044059e-07 2380 3527.18181818182 3624 3.94623807625386e-08 2379 1.34126839900695 1.37903329110016 1 9.78215027565128 2379 4643 4126 4609 2459 2519 2513 3624 3568 4466 3893 4016 M13097 GO_PROTEIN_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_STABILIZATION.html Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. 150/182 Gene Ontology BP GO:0050821 4.84640451777141e-06 6.0375690016574e-06 4130 3717.90909090909 3624 4.40583199454806e-07 3189 1.77901775097509 1.99279715037007 1 11.1262226951121 4165 4130 3624 3320 3711 3189 3614 3468 3225 4325 4126 4017 M14100 GO_REGULATION_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. 1048/1431 Gene Ontology BP GO:0032880 6.97985557321761e-08 4.02645553947883e-07 3970 2681 3625 6.97985579245035e-09 158 1.88825771472111 -1.77072322271564 -1 14.5011846950673 3970 1340 4474 158 680 4276 3625 4268 1755 964 3981 4018 M14122 GO_PROTEIN_K48_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. 20/28 Gene Ontology BP GO:0071108 1.83306571001838e-05 2.08641260976407e-05 3625 3629.09090909091 3625 1.66643725774024e-06 2448 1.79348125250041 1.76804362911718 1 10.0494104200131 2903 4262 3507 4253 4063 3625 2976 2448 4035 4226 3622 4019 M14611 GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. 26/28 Gene Ontology BP GO:0031146 0.000965210473012355 0.000995593954982595 4205 3573.90909090909 3625 8.77849274593989e-05 2080 1.26307455003243 -1.03039311077164 -1 4.48264868625564 4202 2080 3625 3908 4487 4156 3017 3309 2647 3405 4477 4020 M12348 GO_ERROR_FREE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_FREE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. 22/26 Gene Ontology BP GO:0070987 1.74495179774447e-05 1.99001488110418e-05 1650 3225.54545454545 3626 1.58633239832385e-06 1587 0.87981886730924 1.02382837483524 1 4.89929694791958 1646 4257 3906 3626 4052 1828 1587 2703 4521 4273 3082 4021 M14937 GO_REGULATION_OF_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cilium assembly. 56/66 Gene Ontology BP GO:1902017 4.30727802509502e-08 4.02645553947883e-07 4415 2921.63636363636 3626 3.91570737220474e-09 169 1.57477695948857 -1.37840659137451 -1 12.0766652118626 4411 423 3128 3157 169 4020 4495 3755 588 3626 4366 4022 M10298 GO_REGULATION_OF_RNA_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_STABILITY.html Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. 160/186 Gene Ontology BP GO:0043487 3.64496823465991e-06 4.64149895891422e-06 1790 3423.45454545455 3627 3.31361297606449e-07 1786 1.1524673751521 1.06078057500981 1 7.33060581638809 1786 4359 4147 4296 3627 1994 2042 3375 3945 4523 3564 4023 M12020 GO_HISTONE_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MONOUBIQUITINATION.html The modification of histones by addition of a single ubiquitin group. 25/26 Gene Ontology BP GO:0010390 2.11874474762423e-05 2.39516990055771e-05 3160 3579.72727272727 3628 1.92615013891389e-06 2559 0.724668447499216 0.806183296130004 1 3.94664772867376 3156 3756 4023 3628 4094 3179 3091 2559 4189 4409 3293 4024 M11611 GO_REGULATION_OF_INTERLEUKIN_10_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-10 secretion. 8/20 Gene Ontology BP GO:2001179 0.000133724675749781 0.000142221923717425 2965 3386.45454545455 3629 1.33732723461376e-05 758 1.70300203176862 1.46959476017799 1 7.82041588205481 2962 3865 4316 3553 4361 2280 758 3987 4215 3325 3629 4025 M11425 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE.html Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. 12/29 Gene Ontology BP GO:0042749 4.36155218046171e-06 5.47902329797202e-06 4230 3385.63636363636 3631 3.96505529760579e-07 2036 2.52474312509752 -1.73839369367184 -1 15.9619787405729 4226 3380 2036 3479 3680 3816 2490 3793 3631 2567 4144 4026 M12152 GO_INNER_CELL_MASS_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_CELL_MASS_CELL_PROLIFERATION.html The proliferation of cells in the inner cell mass. 10/11 Gene Ontology BP GO:0001833 0.000281113973910569 0.000294599846983306 4095 3652.36363636364 3631 2.55590818929472e-05 2684 0.951496449866245 1.12608173656991 1 3.96002796139635 4091 3389 3529 3049 4419 3861 2684 3431 3818 3631 4274 4027 M13058 GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. 42/62 Gene Ontology BP GO:0032007 8.26955851543725e-05 8.90494232176105e-05 1735 2940.63636363636 3633 7.51806306856696e-06 1023 1.21453469794893 -1.14695025377118 -1 5.84644693922592 1733 4445 3877 3633 4294 2082 1417 1762 4096 3985 1023 4028 M13474 GO_RNA_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DESTABILIZATION.html Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. 21/23 Gene Ontology BP GO:0050779 2.3606488138986e-07 5.40178690738178e-07 2575 3401.72727272727 3633 2.14604460654681e-08 1970 1.12944256384977 -1.66518196287607 -1 8.4580503004269 2571 3771 3745 3813 1970 3633 3005 3389 4018 3946 3558 4029 M15397 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein. 40/68 Gene Ontology BP GO:0042516 3.68397810549632e-06 4.68348364067606e-06 4420 3588.81818181818 3633 3.3490766131481e-07 2333 2.12455622808089 2.00655458245544 1 13.5906562264899 4417 3952 2333 3068 3633 4462 4021 3261 3510 3140 3680 4030 M12632 GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. 690/914 Gene Ontology BP GO:0007167 5.87933630847013e-08 4.02645553947883e-07 3920 2765.36363636364 3634 5.8793364640198e-09 477 1.99496873545702 2.24025330475784 1 15.3265079231389 3918 1397 4380 855 477 3634 3967 4616 2058 541 4576 4031 M14732 GO_HISTONE_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving an mRNA encoding a histone. 28/31 Gene Ontology BP GO:0008334 3.41037995513561e-05 3.7926620294565e-05 1640 3227.54545454545 3634 3.10039347551113e-06 1046 0.690925236744218 0.731921723942797 1 3.59129037784662 1637 3760 4049 3634 4162 1905 1046 3227 4502 4443 3138 4032 M16218 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. 760/1067 Gene Ontology BP GO:0000122 3.59573430984554e-07 7.04164635678085e-07 2345 3484.36363636364 3635 3.59573489166441e-08 2225 1.6181964601356 -1.39520446199538 -1 11.9374052313508 2342 4336 4604 4434 2399 2615 2225 4484 3635 4140 3114 4033 M10472 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. 15/16 Gene Ontology BP GO:0032211 0.00125505310599919 0.00129027001816488 1110 3020.63636363636 3636 0.000114160878127208 174 1.2040624714149 1.2040624714149 1 4.10444007239948 1110 4576 3740 4252 4582 1130 174 3577 3636 4347 2103 4034 M15180 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 30/31 Gene Ontology BP GO:0032205 0.00273799004966225 0.00280243460208501 1180 2967.54545454545 3637 0.000249218503577343 512 1.05420408321089 1.1639302014049 1 3.15131095730628 1179 4487 4006 3637 4527 1646 512 2316 3749 4457 2127 4035 M11901 GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of cell proliferation. 821/1274 Gene Ontology BP GO:0008284 3.33934490351426e-11 9.4169526279102e-10 4345 2684.63636363636 3638 3.33934490356444e-12 96 2.12909690513809 2.30422745330804 1 23.1385382203887 4344 1378 4332 702 363 4044 3944 3638 2323 96 4367 4036 M10963 GO_POSITIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LOCOMOTION.html Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. 517/658 Gene Ontology BP GO:0040017 5.76365708354109e-09 1.01201118527233e-07 3640 2698.63636363636 3639 5.76365709848996e-10 150 2.29349252775833 2.35250078864116 1 19.2988658415956 3639 1448 4271 436 431 3988 4011 4253 2531 150 4527 4037 M13872 GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 220/242 Gene Ontology BP GO:0061136 1.30414078543324e-07 4.18739690741189e-07 4065 3462.72727272727 3639 1.18558260249234e-08 1344 1.46194528619891 -1.3237099449764 -1 11.1739089434903 4061 3639 4012 2628 1344 3305 3606 4186 2499 4332 4478 4038 M14625 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION.html A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. 43/47 Gene Ontology BP GO:0033683 7.51233622602118e-05 8.10830444436942e-05 1195 3218.54545454545 3639 6.82962978354672e-06 1194 0.894430319894185 0.982470298664735 1 4.32244114686581 1194 3966 4081 3639 4282 1792 1323 2922 4540 4442 3223 4039 M13119 GO_GAS_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAS_TRANSPORT.html The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/23 Gene Ontology BP GO:0015669 8.90137904403178e-06 1.05766385832175e-05 2645 3267.63636363636 3640 8.90141469977978e-07 248 4.25526691175486 -5.8756316822107 -1 25.5032840731287 2644 4324 4408 4113 4592 3640 3438 248 3907 3523 1107 4040 M14472 GO_NUCLEAR_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_IMPORT.html The directed movement of substances into the nucleus. 137/180 Gene Ontology BP GO:0051170 1.1591961106517e-06 1.6782014632428e-06 3645 3612.27272727273 3643 1.05381520131006e-07 2258 1.34089515475315 1.04237278910718 1 9.26246836078512 3416 3897 4046 3641 3177 2603 2258 4391 3643 4285 4378 4041 M11034 GO_C21_STEROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 25/43 Gene Ontology BP GO:0008207 3.82930185231332e-06 4.8549704410937e-06 2950 3746.18181818182 3644 3.48118956143707e-07 2949 1.97052329357551 -1.48478336542477 -1 12.5606334266336 2949 4229 2960 4378 3644 3939 3478 4581 4279 3283 3488 4042 M16132 GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. 13/22 Gene Ontology BP GO:0002523 7.29597275971919e-07 1.16700451189321e-06 4265 3068.72727272727 3644 6.63270470847377e-08 1327 2.56806656203218 -3.63843068697232 -1 18.3236047033435 4263 2238 1327 3698 2866 4526 4022 1753 4034 1385 3644 4043 M13217 GO_SPERM_EGG_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_EGG_RECOGNITION.html The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. 36/76 Gene Ontology BP GO:0035036 2.46101730366104e-05 2.76530150058798e-05 3645 3393.90909090909 3645 2.23731348556385e-06 2100 2.74648196054166 -2.46414248829513 -1 15.0376955717433 4510 3957 2288 2959 4118 3645 2647 3641 2100 3711 3757 4044 M14950 GO_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_LINEAGE_COMMITMENT.html The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. 8/16 Gene Ontology BP GO:0002360 0.0824696149071802 0.0829151076411214 3645 3792.09090909091 3645 0.00857002440701519 2820 1.53828415441013 -1.5604747587308 -1 1.90881262776633 3645 3611 4527 3959 4637 4259 3418 2925 4474 2820 3438 4045 M15159 GO_RESPONSE_TO_DEXAMETHASONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DEXAMETHASONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 32/45 Gene Ontology BP GO:0071548 0.00105806300620768 0.00109040247350705 3220 3546.36363636364 3645 9.62338374105129e-05 1702 1.6453777658939 1.185871563432 1 5.79199407935625 3220 4460 3067 4373 4494 2704 1702 3892 3989 3645 3464 4046 M12031 GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that activates or increases the frequency, rate or extent of translational initiation. 21/25 Gene Ontology BP GO:0045948 0.000378752517235964 0.000395231097263723 2620 3469.09090909091 3646 3.44379762799065e-05 2252 1.50890751680366 -1.82093119383924 -1 6.10734223182261 2618 4277 3646 4264 4438 3089 2453 2252 4078 4253 2792 4047 M11247 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. 3/14 Gene Ontology BP GO:0002839 5.81143867245204e-05 6.32529219717411e-05 3495 3790.09090909091 3647 5.81159065573342e-06 2887 0.831676996171515 -1.06695616558712 -1 4.12043269463608 3495 3619 4288 3536 4259 4137 3785 2887 4440 3598 3647 4048 M15624 GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. 551/689 Gene Ontology BP GO:0071900 9.83911904419965e-08 4.02645553947883e-07 4130 3032.45454545455 3647 9.83911947983686e-09 1121 1.92049552621539 -1.73964151382027 -1 14.7505180297588 4130 1445 4564 1663 1121 4184 3647 4637 2615 1447 3904 4049 M11946 GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. 10/11 Gene Ontology BP GO:0033262 0.0688491594017192 0.0692959417469608 2940 3754.72727272727 3648 0.00646392698217883 2940 0.880614210117571 1.06895273140316 1 1.13170286618026 2940 3860 3648 3309 4608 4052 3202 3615 4469 3965 3634 4050 M13866 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. 3/14 Gene Ontology BP GO:0002836 5.81143867245204e-05 6.32529219717411e-05 3500 3804.81818181818 3648 5.81159065573342e-06 2872 0.831676996171515 -1.06695616558712 -1 4.12043269463608 3496 3620 4456 3537 4260 4138 3786 2872 4441 3599 3648 4051 M14059 GO_NEGATIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BINDING.html Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 174/229 Gene Ontology BP GO:0051100 9.49625994520667e-07 1.43507949090765e-06 3655 3456.81818181818 3651 8.63296731295678e-08 2606 1.81093362085242 -1.47148645802786 -1 12.6942920017922 3651 3887 2866 3077 3043 3729 3281 3874 3707 2606 4304 4052 M12117 GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. 29/35 Gene Ontology BP GO:0060765 2.08977754646504e-07 5.04866818468424e-07 3785 3366.09090909091 3653 1.89979794997527e-08 1851 1.41711377297809 -1.76002955403859 -1 10.6888754534315 3785 3732 3617 2144 1851 4119 3283 4129 2682 3653 4032 4053 M14158 GO_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. 132/157 Gene Ontology BP GO:0045444 2.17375989633816e-07 5.1420969993195e-07 4125 3396.54545454545 3653 1.97614555556497e-08 1896 1.97741320102621 2.1795622198015 1 14.9367135968715 4121 3653 2176 3412 1896 4631 4124 3727 3133 2219 4270 4054 M13645 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. 29/34 Gene Ontology BP GO:1900078 5.89520168973194e-07 1.00169569646047e-06 4515 3660.63636363636 3654 5.35927569948425e-08 2696 1.68719072289367 -1.63005356732631 -1 12.1384446510424 4511 3983 3019 3106 2696 3801 3531 3112 4247 3654 4607 4055 M14695 GO_HISTONE_H2A_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_ACETYLATION.html The modification of histone H2A by the addition of an acetyl group. 16/18 Gene Ontology BP GO:0043968 3.92833648651517e-06 4.96493222513865e-06 3065 3164.45454545455 3654 3.57122136454525e-07 821 0.750462575867589 0.848469026805956 1 4.71107075399235 3064 4063 3868 4038 3654 1822 821 3226 4508 4074 1671 4056 M15816 GO_PYRUVATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRUVATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. 57/83 Gene Ontology BP GO:0006090 7.99126960647183e-06 9.55625224335991e-06 4125 3595.63636363636 3655 7.2648169400631e-07 2592 1.50527057445612 1.06407827143778 1 9.03527918848928 4125 3932 3655 3521 3865 3910 3639 2592 3440 4051 2822 4057 M16363 GO_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of JUN kinase activity. 119/166 Gene Ontology BP GO:0043506 3.9288374066109e-06 4.96493222513865e-06 3005 3307.90909090909 3655 3.57167674807683e-07 1881 1.68368759412678 -1.51792163702839 -1 10.6974743789002 3002 3657 3006 4259 3655 2531 1881 4207 3794 3668 2727 4058 M14850 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 809/1011 Gene Ontology BP GO:0080135 1.17119971428855e-07 4.08625383150012e-07 3640 3552.27272727273 3656 1.17119977601545e-08 1326 1.60300874220254 -1.50031052072617 -1 12.282602928447 3636 3625 4520 4064 1326 4314 3923 3656 3117 4137 2757 4059 M16934 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. 8/21 Gene Ontology BP GO:0023019 1.69706034597091e-06 2.33483790354898e-06 3850 3289.90909090909 3659 1.69706164197852e-07 432 2.39084277757093 -1.82965910002862 -1 16.1811090240432 3850 2294 4652 2666 3392 4344 4374 3659 432 2822 3704 4060 M10374 GO_REGULATION_OF_ICOSANOID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ICOSANOID_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. 20/42 Gene Ontology BP GO:0032303 8.17992558729365e-07 1.27893796228755e-06 4500 3302.81818181818 3660 7.43629875337513e-08 990 1.8562981765809 2.04230357148219 1 13.127177383662 4497 990 2028 3713 2933 4336 3001 3660 4429 2274 4470 4061 M13667 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. 40/49 Gene Ontology BP GO:0061418 6.26657237515355e-06 7.62509447217298e-06 3660 3616.63636363636 3660 5.69690020472056e-07 2627 1.52723741932049 1.87623344909324 1 9.34972398329694 3660 3954 3310 2627 3796 4247 3825 3728 3528 3549 3559 4062 M12658 GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 33/48 Gene Ontology BP GO:0097237 4.27830888613878e-05 4.71394062211786e-05 4590 3535.36363636364 3661 3.88944735279259e-06 1432 2.25486995735019 2.3856391536764 1 11.6958696888426 4587 3977 2680 2817 4195 4494 3661 1432 3339 3507 4200 4063 M14963 GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. 19/24 Gene Ontology BP GO:1903672 6.28049780314663e-05 6.81856725849292e-05 3665 3631.18181818182 3662 5.70970645835315e-06 2571 1.70459203988446 2.44813941750222 1 8.48600498154305 3662 3783 2771 3568 4254 3928 4637 2571 3467 3573 3729 4064 M15085 GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. 106/158 Gene Ontology BP GO:0043467 2.52712649693942e-07 5.63157068499e-07 3335 3466.18181818182 3663 2.29738798838994e-08 2027 1.66145336089259 1.69381890793731 1 12.4542602219346 3332 3663 3347 4201 2027 2766 2874 3831 3964 3740 4383 4065 M15998 GO_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BINDING.html Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 390/486 Gene Ontology BP GO:0051098 3.69945413491533e-07 7.16336250094093e-07 4190 3747.36363636364 3663 3.36314068818601e-08 2348 1.66172698662233 1.84005671174609 1 12.246341203595 4189 3877 3520 3351 2348 4189 3663 4494 3628 3532 4430 4066 M15162 GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organonitrogen compound. 969/1252 Gene Ontology BP GO:1901566 1.44406871119032e-07 4.30721263664652e-07 3410 3710.90909090909 3664 1.44406880503038e-08 1574 1.58512315800527 1.68055648235038 1 12.1005662725478 3408 4602 4538 4508 1574 3512 3664 3450 3203 4427 3934 4067 M12983 GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. 9/20 Gene Ontology BP GO:0014821 2.08809200345103e-06 2.80320025737381e-06 4070 3046.54545454545 3667 2.08809396551131e-07 781 2.78743211536742 -2.26142200558994 -1 18.6146275149689 4068 1240 4398 781 3477 3948 3667 3742 3095 920 4176 4068 M13756 GO_VESICLE_COATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COATING.html A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. 102/116 Gene Ontology BP GO:0006901 3.93695922217081e-07 7.50765215604951e-07 3670 3573.81818181818 3667 3.57905447881858e-08 2369 1.80240408581308 -1.16471394113887 -1 13.2473573617259 3667 3665 3160 3819 2391 3843 3144 4577 2369 4056 4621 4069 M13738 GO_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NIK_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). 94/119 Gene Ontology BP GO:0038061 6.55602480344065e-06 7.94612748382635e-06 1650 3348.63636363636 3668 5.9600403095909e-07 1647 1.34971212663679 -1.53570128139125 -1 8.22171344395737 1647 3668 3886 2352 3814 3449 3318 4589 3673 4250 2189 4070 M11438 GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. 81/164 Gene Ontology BP GO:0030518 8.30931304594827e-07 1.29408206566537e-06 3830 3589 3670 7.55392380394966e-08 2159 1.54238310998188 1.6372462857113 1 10.8803179726716 3827 3188 3670 3239 2943 4183 4214 4354 2159 4142 3560 4071 M12478 GO_NCRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_TRANSCRIPTION.html The transcription of non (protein) coding RNA from a DNA template. 92/106 Gene Ontology BP GO:0098781 5.79800176977623e-06 7.11635511336555e-06 4120 3265.45454545455 3671 5.27092459109763e-07 1655 0.979313825210076 0.871661020807519 1 5.99392294834409 2190 3671 4118 3847 3763 1655 2177 3061 4117 4512 2809 4072 M14069 GO_CELLULAR_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 5/13 Gene Ontology BP GO:0071294 0.00471636912710777 0.00480728708618455 3825 3616.63636363636 3671 0.000472640899150403 1729 0.570247580690469 -0.570247580690469 -1 1.49573352159433 3822 3616 4472 3300 4551 3525 1729 1958 4511 4628 3671 4073 M14180 GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 82/97 Gene Ontology BP GO:0009124 5.06519414237316e-07 8.92064661031881e-07 2150 3403.63636363636 3672 4.60472300778551e-08 2147 1.12304690947119 1.05656296118209 1 8.11367407540929 2147 3672 4010 4210 2595 2860 2563 3700 3287 4360 4036 4074 M10303 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. 132/145 Gene Ontology BP GO:0043624 3.35035034065574e-06 4.29690742422028e-06 1535 3480.90909090909 3673 3.04577767533635e-07 1531 1.4941072632482 1.51522047072625 1 9.59476483582223 1531 4373 4096 4433 3604 2689 1970 3647 3788 4486 3673 4075 M16838 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 29/39 Gene Ontology BP GO:0045922 1.32338214574046e-05 1.53290941601452e-05 4370 3603.63636363636 3673 1.20308191495022e-06 2817 1.40561358278444 -0.968002346531162 -1 8.08140096120631 4369 3256 3231 3302 3989 4078 3673 2941 2817 3845 4139 4076 M15446 GO_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRINOLYSIS.html A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. 18/29 Gene Ontology BP GO:0042730 6.54124822698245e-06 7.93235027369021e-06 4310 3136.09090909091 3674 5.94660697829251e-07 714 2.86951265625409 -2.18385317617903 -1 17.5980608882813 4307 3008 999 2672 3812 3674 4572 3119 3715 714 3905 4077 M15578 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. 21/31 Gene Ontology BP GO:2000353 3.03077317429293e-06 3.91184121497503e-06 3580 3557.09090909091 3675 2.75525213597033e-07 1675 3.25241760790993 -2.73238069859877 -1 21.1677225493607 3675 3777 1675 2727 3580 4587 4272 4381 3580 2841 4033 4078 M16236 GO_SNRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. 83/91 Gene Ontology BP GO:0016073 3.76584771681744e-05 4.16805171892283e-05 1265 3132.72727272727 3675 3.42355652747409e-06 1264 0.779029925595251 0.786141825367055 1 4.02375167136888 1264 3675 4162 4284 4173 1388 1554 2366 4422 4547 2625 4079 M11845 GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 151/171 Gene Ontology BP GO:0035967 4.04690426930609e-07 7.64835319459027e-07 2985 3693.45454545455 3676 3.67900455794101e-08 2413 1.1392566185743 -1.0975026384545 -1 8.32434747962131 2981 4362 4159 4621 2413 3452 3028 3403 4003 4530 3676 4080 M11562 GO_DNA_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEALKYLATION.html The removal of an alkyl group from one or more nucleotides within an DNA molecule. 17/20 Gene Ontology BP GO:0035510 2.30335043437106e-06 3.0508083037656e-06 4215 3752.18181818182 3679 2.09395713266419e-07 3161 1.24957890764452 -0.771994559986298 -1 8.23240070957787 4214 3329 3435 4502 3479 4302 3161 3679 3193 4270 3710 4081 M13181 GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 20/22 Gene Ontology BP GO:0071243 0.00074170413378938 0.000767433696802754 1765 2952.18181818182 3679 6.74503917005916e-05 466 1.39328204586429 -1.58347292310792 -1 5.14584678605724 1761 4530 3679 4534 4574 1694 466 1185 4248 4081 1722 4082 M15933 GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING.html The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. 20/23 Gene Ontology BP GO:0000729 1.90001052977493e-05 2.15631747017094e-05 1420 3010.72727272727 3679 1.72729721749648e-06 1265 1.23262401399488 1.33913371776067 1 6.85322696021548 1419 4270 3746 3993 4075 1265 1585 3139 4106 3679 1841 4083 M12163 GO_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 1461/2167 Gene Ontology BP GO:0009719 3.68780631840605e-12 1.17529882188653e-10 4560 2734.54545454545 3681 3.68780631841217e-13 90 2.09562216710844 2.24361818736059 1 25.0636543377808 4560 1313 4349 334 432 4177 3681 4361 2145 90 4638 4084 M13233 GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 60/75 Gene Ontology BP GO:0009142 3.05272346775393e-07 6.32560372007763e-07 2615 3230.09090909091 3681 2.77520353759128e-08 1503 1.22006899360979 1.18020781767536 1 9.04381500176003 2611 3681 3814 3735 2188 3401 2442 3824 1503 4197 4135 4085 M15923 GO_CELLULAR_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. 14/14 Gene Ontology BP GO:0043482 4.65217650428497e-05 5.11376736934514e-05 1295 2942.18181818182 3681 4.22934080301517e-06 838 0.913831384560641 -0.903190333605338 -1 4.63967837673215 1293 4071 3681 4347 4204 1381 838 1629 4551 4171 2198 4086 M11348 GO_RIBOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_ASSEMBLY.html The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. 57/75 Gene Ontology BP GO:0042255 9.65065336050637e-07 1.45200861439524e-06 4440 3644.36363636364 3682 8.7733250853846e-08 2081 0.619026778257318 -0.57134293840841 -1 4.26768011291922 2205 4439 4146 4440 3056 3385 2081 3511 4623 4520 3682 4087 M13294 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP.html Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. 7/13 Gene Ontology BP GO:0045188 0.000109906639666771 0.000117400274189505 1815 2818.27272727273 3682 1.0991207580642e-05 96 1.82346227882942 -1.82346227882942 -1 8.56456330952659 1815 4328 4418 3798 4518 933 265 2759 4389 3682 96 4088 M15953 GO_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXECUTION_PHASE_OF_APOPTOSIS.html A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. 63/76 Gene Ontology BP GO:0097194 1.47547575980861e-06 2.06477855951562e-06 3685 3673.54545454545 3682 1.34134249942549e-07 2635 1.72567937053352 -1.66682468959355 -1 11.7620834178036 3418 3682 3322 3061 3293 4354 4461 4269 2635 3684 4230 4089 M16896 GO_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. 14/14 Gene Ontology BP GO:0043476 4.65217650428497e-05 5.11376736934514e-05 1295 2953.63636363636 3682 4.22934080301517e-06 839 0.913831384560641 -0.903190333605338 -1 4.63967837673215 1294 4072 3682 4348 4205 1382 839 1745 4552 4172 2199 4090 M15721 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. 58/65 Gene Ontology BP GO:2001238 6.34993395905014e-07 1.05824651545345e-06 4475 3665.54545454545 3685 5.77266890168514e-08 2588 1.66117762238103 1.53259235817304 1 11.9017894465762 4472 3685 3291 2588 2750 4550 3861 3510 3891 3207 4516 4091 M16863 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. 10/15 Gene Ontology BP GO:0043568 8.62307567598251e-06 1.02748197491285e-05 3885 2983.36363636364 3685 7.8391904318197e-07 521 3.9170003531101 5.60812131051562 1 23.5273143679993 3884 4098 1840 3705 3878 4602 3685 632 521 2696 3276 4092 M15292 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that modulates the frequency, rate or extent of protein localization to nucleus. 274/363 Gene Ontology BP GO:1900180 1.1559116307033e-07 4.08387002100415e-07 4395 3000.36363636364 3687 1.05082881039688e-08 1034 1.90377362555472 1.89443407543488 1 14.607030105223 4391 2355 2756 1034 1204 4442 4339 3768 1324 3704 3687 4093 M16528 GO_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCONEOGENESIS.html Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. 46/84 Gene Ontology BP GO:0006111 4.88627607758616e-05 5.36602374062034e-05 4070 3721.45454545455 3688 4.44216782440202e-06 2756 1.72047398842474 2.10566248914244 1 8.78251064501968 4066 3941 3229 3582 4211 4376 4373 2756 3688 3164 3550 4094 M11352 GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. 12/12 Gene Ontology BP GO:0051103 2.25531511864141e-05 2.54153093897759e-05 4090 2769.27272727273 3690 2.05030749016693e-06 620 0.957140312058683 1.08381966685805 1 5.21593352047255 2300 4088 3690 4219 4107 1064 628 620 4406 4088 1252 4095 M12994 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. 25/26 Gene Ontology BP GO:0032232 4.33766551870009e-07 8.0539336227101e-07 4470 3273.18181818182 3690 3.94333306722104e-08 2072 1.60407618314582 1.54835851095037 1 11.7191761800428 4470 2072 2358 3690 2458 4350 4132 2311 3800 2630 3734 4096 M13041 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. 20/21 Gene Ontology BP GO:1904357 0.000257286296984784 0.000270176741112661 1345 3148.27272727273 3690 2.33923991919555e-05 784 1.05224884825446 1.09911329795212 1 4.43808047776542 1345 4538 3860 4055 4410 1682 784 3413 3690 4424 2430 4097 M14169 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. 18/21 Gene Ontology BP GO:0045986 0.0141600643158085 0.0143325602047982 3130 3571.18181818182 3691 0.00129563944187649 2338 2.1134404456359 2.29689802185359 1 4.60945882681074 3128 4263 2628 4324 4577 2835 3949 3691 3896 2338 3654 4098 M15301 GO_MITOCHONDRION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_MORPHOGENESIS.html The process in which the anatomical structures of a mitochondrion are generated and organized. 28/37 Gene Ontology BP GO:0070584 6.54787148847495e-08 4.02645553947883e-07 4330 3146.36363636364 3691 5.95261062123601e-09 493 1.51369995387193 1.70124689526068 1 11.6042840923789 4326 2581 3277 2580 493 4352 3691 4536 648 3960 4166 4099 M16520 GO_ENDODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the endoderm. 7/16 Gene Ontology BP GO:0001711 9.87788819767322e-05 0.000105829642605972 2760 3646 3691 9.87832730218243e-06 2318 0.579030968391103 -0.685934265142367 -1 2.68092427309742 2756 3866 4629 3605 4327 2776 2318 3138 4349 4651 3691 4100 M10446 GO_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 1272/1714 Gene Ontology BP GO:0044248 9.40731189150674e-08 4.02645553947883e-07 2905 3562.09090909091 3694 9.40731228974557e-09 1055 1.50112674252029 -1.4048360033776 -1 11.5070404964654 2902 4601 4240 4600 1055 3296 3048 4066 3109 4572 3694 4101 M12288 GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING.html Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. 9/11 Gene Ontology BP GO:0006346 9.51952045399245e-05 0.000102154817048955 4320 3698.27272727273 3694 9.51992827429382e-06 2990 1.22479524358426 1.16221711630148 1 5.80838384648612 3772 4320 4360 3301 4319 3694 3173 2990 4015 3521 3216 4102 M13698 GO_AMINO_SUGAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 11/17 Gene Ontology BP GO:0046348 0.179962117519517 0.180699985502442 3695 3699.54545454545 3694 0.0178751052923964 1778 1.75484677217385 -1.04116995509864 -1 1.47400520508307 3694 4594 3577 3824 4622 3226 1778 3613 4275 4030 3462 4103 M11482 GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. 68/77 Gene Ontology BP GO:0072384 4.66837192678964e-06 5.83766046099226e-06 3495 3731.45454545455 3696 4.24398348458611e-07 2841 1.4202965594242 -0.937116406096462 -1 8.8870888537001 3491 4159 3781 4527 3696 3346 2841 4411 3150 4218 3426 4104 M13523 GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. 4/19 Gene Ontology BP GO:0006704 2.01432477520725e-06 2.71356490418046e-06 3875 3374.36363636364 3697 2.01432660108651e-07 643 3.43359304208147 -1.86404142302067 -1 23.0122023101014 3875 2753 4432 3681 3462 4459 4578 643 4136 1402 3697 4105 M16491 GO_PROTEIN_TARGETING_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_LYSOSOME.html The process of directing proteins towards the lysosome using signals contained within the protein. 24/25 Gene Ontology BP GO:0006622 4.68040563856371e-06 5.85113579694705e-06 2235 3183.27272727273 3697 4.25492326905056e-07 1614 1.0463966468421 -1.02709417253324 -1 6.51914854307972 2235 3754 3739 4015 3697 1884 1614 2946 4548 4398 2186 4106 M15645 GO_PROTEIN_K48_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. 52/61 Gene Ontology BP GO:0070936 2.57178043494408e-06 3.3708434827591e-06 4115 3739.09090909091 3698 2.33798494667042e-07 3107 1.11364275265688 -1.1337302405662 -1 7.26728407391419 4111 3689 4004 3107 3519 3905 3698 3560 3260 4174 4103 4107 M14425 GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. 64/76 Gene Ontology BP GO:0009168 1.21222345234963e-06 1.7414250459348e-06 2270 3500.54545454545 3699 1.10202192754381e-07 2268 1.08350646487031 1.01648068708383 1 7.44370204869631 2268 3921 3998 4232 3197 3012 2649 3699 3151 4433 3946 4108 M11801 GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle. 29/37 Gene Ontology BP GO:1900087 1.72035195308487e-05 1.96391992991846e-05 2155 2890.54545454545 3700 1.563968550917e-06 1271 1.51278995158425 1.54021872241475 1 8.50857417962599 2151 4220 3700 4004 4047 1795 1337 1271 4011 3843 1417 4109 M10751 GO_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. 506/646 Gene Ontology BP GO:0030029 3.78975769989752e-08 4.02645553947883e-07 3860 2515.18181818182 3701 3.78975776452771e-09 151 2.1456920008422 2.3634339264795 1 16.4922301800842 3859 1433 4259 670 151 4182 3919 3701 1250 173 4070 4110 M11719 GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 50/83 Gene Ontology BP GO:0030811 5.08839757241183e-07 8.94796443856094e-07 4490 3583.54545454545 3701 4.62581704482886e-08 2149 1.40721064564429 1.41881671008661 1 10.1904624684553 4486 3485 3526 2149 2599 4034 3618 3979 3701 4038 3804 4111 M11854 GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. 122/129 Gene Ontology BP GO:1901800 2.79162919605973e-07 5.94468750547965e-07 4565 3550.81818181818 3701 2.53784504572351e-08 2127 1.55008797271807 -1.43425319870381 -1 11.5685098904753 4564 3439 3701 3817 2127 4014 4194 2985 2714 4269 3235 4112 M15071 GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. 17/23 Gene Ontology BP GO:0046321 3.84155914242689e-07 7.37233164478964e-07 3705 3269.90909090909 3701 3.49232710293272e-08 2185 1.82617602505688 1.72683737272919 1 13.4408810333499 3701 3015 2244 2751 2374 3827 3751 3850 3986 2185 4285 4113 M13902 GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of erythrocyte differentiation. 39/48 Gene Ontology BP GO:0045646 1.10002824868686e-06 1.60553056497489e-06 4185 3859.45454545455 3702 1.00002618065045e-07 3156 1.33955718521689 1.34590013105359 1 9.28426980098686 4183 3702 3484 3577 3156 4616 4419 3437 4328 3262 4290 4114 M14822 GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY.html The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 24/26 Gene Ontology BP GO:0035058 0.000108142170544763 0.000115568562137065 1260 2564.45454545455 3703 9.83158969968582e-06 437 1.47794471090626 1.47367381662879 1 6.93441071535761 1260 4233 3724 4003 4325 749 437 1109 3703 3743 923 4115 M16450 GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. 17/19 Gene Ontology BP GO:1900119 7.20760946026428e-05 7.78818936851625e-05 4275 3092.36363636364 3703 6.55258691436013e-06 241 3.25624183492388 3.57304519720155 1 16.0769359281208 4027 3334 1901 1423 4275 4272 4338 2189 241 3703 4313 4116 M11928 GO_HISTONE_H3_K9_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K9_MODIFICATION.html The modification of histone H3 at a lysine in position 9 of the histone. 20/20 Gene Ontology BP GO:0061647 8.64153592441997e-05 9.29689402458407e-05 2745 3453.90909090909 3704 7.85625034554687e-06 1638 1.25494689365056 1.43215072764531 1 6.01601448190014 2743 4255 3704 4377 4300 2857 1638 3580 3890 4080 2569 4117 M11970 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 16/37 Gene Ontology BP GO:0050716 7.89414516295995e-07 1.24429056379582e-06 4480 3246.63636363636 3704 7.1764981777966e-08 1104 2.44648309753318 -3.09853374472299 -1 17.3688113221534 4480 1104 1645 3704 2905 4610 3878 3355 3864 1539 4629 4118 M14119 GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a virus effects a change in the structure or processes of its host organism. 41/58 Gene Ontology BP GO:0019048 1.26538680015847e-06 1.80830613671295e-06 4435 3512.81818181818 3704 1.15035229816268e-07 1209 1.55764218586584 -1.45339042033437 -1 10.7152410659545 4431 3704 3605 2812 3220 4435 3034 3953 1209 4065 4173 4119 M10440 GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. 25/29 Gene Ontology BP GO:0045648 1.81737320212796e-06 2.47692955755752e-06 3710 3581.27272727273 3707 1.65215882129367e-07 2517 1.24912535290357 1.33589519151594 1 8.36609451076052 3707 3749 3451 3992 3385 3915 3950 2517 4213 3281 3234 4120 M12696 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 15/15 Gene Ontology BP GO:0032968 7.53349434922928e-05 8.12925538194894e-05 3580 3637.45454545455 3708 6.848865756564e-06 1801 0.755906464410536 -0.683874943723741 -1 3.63603807952043 3708 3576 3828 3580 4283 3010 1801 3517 4066 4207 4436 4121 M16138 GO_DEFINITIVE_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFINITIVE_HEMOPOIESIS.html A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. 17/21 Gene Ontology BP GO:0060216 0.0115672433047538 0.0117285646321681 3305 3619.63636363636 3708 0.00105713758908089 2151 2.07650436190512 2.13264666597278 1 4.74578397646884 3301 4551 3075 3781 4624 3708 4019 2151 4093 3702 2811 4122 M15747 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 11/18 Gene Ontology BP GO:2000515 2.00389194586739e-06 2.70264035481767e-06 4245 3603.81818181818 3713 1.82172161012244e-07 2388 1.91014850672779 1.45212318020411 1 12.7603269917274 4243 3595 2848 3773 3418 3713 2664 4324 4062 2388 4614 4123 M15786 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 19/22 Gene Ontology BP GO:1902043 9.7257799700556e-05 0.000104223984801172 3850 3704.63636363636 3714 8.8420090498472e-06 3080 1.4857651789286 -1.22631140161217 -1 7.052278272362 3847 4031 3307 3779 4314 3583 3714 3080 4357 3575 3164 4124 M13564 GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 192/252 Gene Ontology BP GO:0010952 8.29053082071177e-08 4.02645553947883e-07 4290 3097.81818181818 3716 7.53684648466733e-09 781 2.14351629513509 2.26686675856517 1 16.4754028604209 4286 3883 1429 2315 781 4330 3716 4009 3116 2433 3778 4125 M16317 GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS.html The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. 11/16 Gene Ontology BP GO:0071428 0.000162103686980701 0.000171815137931936 3630 3753.36363636364 3716 1.47377847799136e-05 3064 0.84639816382055 0.83495657205234 1 3.75095263548493 3630 3848 3716 3596 4370 3916 3224 3064 4352 3350 4221 4126 M13201 GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER.html The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. 14/16 Gene Ontology BP GO:0006390 9.00107577242656e-06 1.0686911347053e-05 4160 3168.18181818182 3718 8.18282963601966e-07 823 1.1736054286448 -1.49294488585977 -1 6.95286709858245 4156 4061 3588 4344 3892 3201 1349 823 4324 3718 1394 4127 M15156 GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 64/76 Gene Ontology BP GO:0009127 1.21222345234963e-06 1.7414250459348e-06 2270 3503.18181818182 3718 1.10202192754381e-07 2269 1.08350646487031 1.01648068708383 1 7.44370204869631 2269 3922 3999 4233 3198 3013 2650 3718 3152 4434 3947 4128 M14372 GO_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that modulates the frequency, rate or extent of the transcription of the viral genome. 70/86 Gene Ontology BP GO:0046782 2.91536475478482e-06 3.77860507075592e-06 3715 3708.90909090909 3719 2.65033510739422e-07 3011 1.25836101078966 1.11697800666538 1 8.14957613817518 3713 3677 3875 3811 3565 3011 3975 3719 3839 3938 3675 4129 M16037 GO_INACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INACTIVATION_OF_MAPK_ACTIVITY.html Any process that terminates the activity of the active enzyme MAP kinase. 26/28 Gene Ontology BP GO:0000188 9.49169794574076e-07 1.43485609296724e-06 4585 3509 3720 8.62882003713559e-08 1444 1.73427172587964 1.95164205940426 1 12.1526903660209 4581 3255 2570 2893 3042 3780 4499 4534 3720 1444 4281 4130 M12200 GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 63/100 Gene Ontology BP GO:0009118 8.82626437977615e-07 1.35450554614441e-06 3725 3452.27272727273 3721 8.02387992801909e-08 2209 1.4307328026848 -1.43911280696819 -1 10.050965374375 3721 3919 3688 4020 2989 3936 3671 2209 3739 3807 2276 4131 M15004 GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. 69/80 Gene Ontology BP GO:0043666 5.54327196461293e-08 4.02645553947883e-07 4335 3518.90909090909 3721 5.03933827662278e-09 338 1.4584010467465 1.62749375513376 1 11.1765918800577 4331 3464 3721 3317 338 4495 3479 4287 3071 3913 4292 4132 M15607 GO_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of ATP metabolic process. 63/100 Gene Ontology BP GO:1903578 8.82626437977615e-07 1.35450554614441e-06 3725 3426.36363636364 3722 8.02387992801909e-08 1914 1.4307328026848 -1.43911280696819 -1 10.050965374375 3722 3920 3689 4021 2990 3937 3672 1914 3740 3808 2277 4133 M11109 GO_IMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving IMP, inosine monophosphate. 13/14 Gene Ontology BP GO:0046040 9.25398417524941e-05 9.94199685232868e-05 1500 2600.09090909091 3723 8.41306677612131e-06 156 0.797986910782795 0.797986910782795 1 3.75981336199128 1497 3834 3723 3809 4306 595 156 981 4503 4304 893 4134 M16115 GO_MITOCHONDRION_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_DISTRIBUTION.html Any process that establishes the spatial arrangement of mitochondria between and within cells. 14/17 Gene Ontology BP GO:0048311 2.06145440715327e-06 2.77384249753736e-06 4210 3457 3724 1.87405121708143e-07 1504 2.02825865637243 -1.52581065432378 -1 13.5279993332128 4206 3810 2867 3285 3429 4049 4597 2782 1504 3724 3774 4135 M11768 GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 129/154 Gene Ontology BP GO:0042177 1.07424406534636e-07 4.02645553947883e-07 4170 3407.18181818182 3726 9.76585561637204e-09 1107 1.48569048470324 -1.37086841295987 -1 11.3876535573933 4169 2822 3560 2138 1107 4337 4312 3855 2847 3726 4606 4136 M14133 GO_TOXIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_TRANSPORT.html The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/59 Gene Ontology BP GO:1901998 2.42719055182057e-05 2.73058937079814e-05 1975 2823.27272727273 3726 2.20656120969213e-06 412 1.57681238248247 1.96944548490837 1 8.60006795891775 1973 3934 3726 3825 4113 1043 412 3121 3925 4173 811 4137 M14416 GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. 18/18 Gene Ontology BP GO:2000001 1.01604531138426e-06 1.50658343972943e-06 3480 3479.27272727273 3726 9.23677982394262e-08 1530 1.01961178012411 -1.12805732005318 -1 7.0762506514574 3478 4038 3756 3590 3098 3726 4130 1530 3915 3996 3015 4138 M16593 GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. 734/956 Gene Ontology BP GO:0034622 4.4694259360359e-07 8.21660959319441e-07 2815 3556.63636363636 3726 4.46942683494573e-08 2127 1.42415782205268 1.45011814569262 1 10.3782093540503 2813 4606 4638 4617 2572 2140 2127 3973 3341 4570 3726 4139 M16555 GO_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING.html Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 51/70 Gene Ontology BP GO:0060968 0.000112618751144445 0.000120214509996582 3650 3710.27272727273 3727 1.02385924136325e-05 1791 1.69948994196123 1.90978548853788 1 7.95413659108341 3649 4435 3727 3630 4331 4071 4453 1791 3677 4148 2901 4140 M12380 GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. 105/149 Gene Ontology BP GO:0002220 4.99808031274627e-05 5.48233561886101e-05 2990 3714.90909090909 3729 4.54381260498165e-06 2990 1.10097781571127 -1.14040236608831 -1 5.57069318293192 2990 3905 4102 3357 4216 4157 3381 3202 3729 4463 3362 4141 M13727 GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 86/103 Gene Ontology BP GO:0042451 1.24746086668275e-06 1.78652982846256e-06 3230 3761.63636363636 3730 1.13405597638922e-07 2967 1.13319766743881 1.1588525492294 1 7.77458307122579 3230 4150 4043 4239 3208 3730 3645 3724 2967 4448 3994 4142 M16242 GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 86/103 Gene Ontology BP GO:0046129 1.24746086668275e-06 1.78652982846256e-06 3235 3758.81818181818 3731 1.13405597638922e-07 2968 1.13319766743881 1.1588525492294 1 7.77458307122579 3231 4151 4044 4240 3209 3731 3646 3683 2968 4449 3995 4143 M13420 GO_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a protein. 875/1131 Gene Ontology BP GO:0006468 7.76426339828402e-08 4.02645553947883e-07 3900 3264.63636363636 3732 7.76426366956105e-09 817 1.82181942682526 1.94529899852524 1 13.9873384038818 3896 2764 4427 2525 817 3732 4575 4128 2639 2306 4102 4144 M16665 GO_NEUROTROPHIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. 31/34 Gene Ontology BP GO:0038179 1.04756898562146e-05 1.23120446832449e-05 4000 3652.18181818182 3732 9.52339976218252e-07 2571 1.79680377105788 -1.02770259498117 -1 10.5659987476201 3999 4461 3090 3075 3932 4449 3732 3652 2571 4191 3022 4145 M12866 GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. 1850/2715 Gene Ontology BP GO:0071310 6.65279811326775e-08 4.02645553947883e-07 2640 3030.81818181818 3733 6.65279831243652e-09 278 2.03557949581984 2.19607628079676 1 15.6405992288536 4646 1295 4391 2638 618 4264 3733 4330 2636 278 4510 4146 M10844 GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 277/312 Gene Ontology BP GO:0034976 2.03155144147465e-07 4.99303437609901e-07 4635 3509.81818181818 3735 1.84686511734066e-08 1820 1.32163981170503 -1.06036485532517 -1 9.96949862912471 2366 4634 4158 4631 1820 3022 2643 3735 3810 4521 3268 4147 M15971 GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 22/23 Gene Ontology BP GO:0048011 4.10983626691115e-06 5.17679159446063e-06 3735 3393.18181818182 3735 3.73622176776977e-07 2132 2.28056559692451 -1.26199489256286 -1 14.4762441421005 3735 4004 2732 2132 3667 4311 3985 3946 2484 4009 2320 4148 M16686 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of hydrogen ion (proton) across a membrane. 85/121 Gene Ontology BP GO:1902600 2.00371426650323e-06 2.70264035481767e-06 3445 3766.54545454545 3737 1.82156008313351e-07 2793 1.3229616443753 -1.50432039165348 -1 8.80610468420672 3445 4149 3925 4202 3417 4567 3598 2793 3213 4386 3737 4149 M10274 GO_NUCLEAR_ENVELOPE_REASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_REASSEMBLY.html The reformation of the nuclear envelope following its breakdown in the context of a normal process. 23/24 Gene Ontology BP GO:0031468 8.12158806798543e-07 1.27238213065105e-06 4260 3486.18181818182 3740 7.38326460561597e-08 832 1.15767131505169 1.39714264107141 1 8.15107643137884 4259 3280 3623 3740 2926 4531 3917 3315 832 4057 3868 4150 M10596 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. 28/29 Gene Ontology BP GO:1902108 2.65858947986963e-07 5.75100736858827e-07 4445 3833 3740 2.41689981922442e-08 2091 1.52700057322249 -1.41718620238947 -1 11.4212378206244 4445 3740 3464 3548 2091 4066 4653 4572 3661 3551 4372 4151 M12813 GO_CELL_REDOX_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_REDOX_HOMEOSTASIS.html Any process that maintains the redox environment of a cell or compartment within a cell. 59/76 Gene Ontology BP GO:0045454 6.96772869039141e-07 1.12728934618885e-06 2660 3540.54545454545 3741 6.33430081561469e-08 2472 1.39428884445469 -1.70812232824825 -1 9.92679287863944 2657 4164 3741 4224 2831 4107 3214 2472 3961 4241 3334 4152 M13193 GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. 26/30 Gene Ontology BP GO:0036119 5.36670959229886e-06 6.63248332880919e-06 3855 3479.09090909091 3741 4.87883880360649e-07 1950 1.65932677318936 2.0496351830626 1 10.2888268085536 3852 3265 2882 4479 3741 4386 4024 1950 3847 2442 3402 4153 M11614 GO_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_KETONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 62/102 Gene Ontology BP GO:0042180 5.99494400300115e-07 1.01484919564643e-06 3315 3569.45454545455 3743 5.44995057873523e-08 2706 1.68416677260728 -1.80151267939918 -1 12.1049643397218 3312 2860 3126 3915 2706 4444 3899 3642 3831 3786 3743 4154 M15253 GO_VIRAL_LATENCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LATENCY.html The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. 13/16 Gene Ontology BP GO:0019042 5.4021682527693e-06 6.66921965511689e-06 2915 3514.36363636364 3744 4.91107410727877e-07 2512 1.05977003042942 0.876050013065331 1 6.53093755507034 2911 3825 3567 4180 3744 2546 2512 3952 4308 3900 3213 4155 M16841 GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 20/24 Gene Ontology BP GO:0060260 0.000554142744705618 0.000574899931129374 1735 2894.72727272727 3744 5.03893066472326e-05 1019 1.59423909025473 1.1795502798511 1 6.14477035725225 1731 4271 3744 4247 4461 1518 1019 1223 4091 3889 1648 4156 M16882 GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. 18/22 Gene Ontology BP GO:0000737 2.85446683077236e-05 3.18815030330864e-05 3750 3201.81818181818 3746 2.59500351611081e-06 1271 1.39073631118191 -1.94741596692592 -1 7.45987771873254 3746 3789 3518 3759 4144 3996 2672 2631 1910 3784 1271 4157 M12400 GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY.html The disaggregation of a macromolecular complex into its constituent components. 212/249 Gene Ontology BP GO:0032984 1.51287447876609e-07 4.37569031250903e-07 2550 3426 3747 1.37534052981997e-08 1512 1.40900925449028 1.56186222584545 1 10.7330297990374 2548 4648 4137 4085 1512 2775 2340 3747 3767 4495 3632 4158 M14888 GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. 45/59 Gene Ontology BP GO:0032881 2.42634660644547e-08 3.39987841817087e-07 4115 3311.36363636364 3748 2.20576966655026e-09 29 1.6985086421036 1.83150030404582 1 13.1845279395979 4113 2509 2687 3748 29 4283 3313 4279 4028 3090 4346 4159 M10037 GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that activates or increases the frequency, rate or extent of viral transcription. 47/51 Gene Ontology BP GO:0050434 5.56052900568747e-06 6.85199720960376e-06 3505 3704.54545454545 3750 5.0550391454978e-07 2986 1.07713009145613 0.949761307056966 1 6.62431094408258 3501 3492 3962 3105 3750 2986 3210 4244 4151 4138 4211 4160 M11366 GO_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_ASSEMBLY.html The aggregation, arrangement and bonding together of the extracellular matrix. 21/22 Gene Ontology BP GO:0085029 0.0013080444105587 0.00134385750548237 3060 3563.45454545455 3750 0.000118983888800472 2021 2.38632677501915 2.69489773277467 1 8.18466436589188 3060 4015 2021 4482 4509 3184 3814 2800 4393 3170 3750 4161 M10776 GO_GLUCOCORTICOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. 7/24 Gene Ontology BP GO:0008211 7.12873435558232e-07 1.14695715617305e-06 3910 3320.18181818182 3751 7.12873664243175e-08 483 3.43359304208147 -1.86404142302067 -1 24.5652376015845 3908 4106 4261 3751 2899 3295 2706 483 4181 2524 4408 4162 M16672 GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. 25/37 Gene Ontology BP GO:0032897 1.35963769879333e-06 1.92116435240977e-06 4390 3743.09090909091 3751 1.23603503552132e-07 2980 1.54401054240905 -1.62632088598848 -1 10.5714693414086 4386 3751 2980 4143 3263 4389 3649 3601 3894 2993 4125 4163 M11639 GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. 150/188 Gene Ontology BP GO:0034249 2.8188502702974e-07 5.98348400890605e-07 2875 3619.09090909091 3753 2.56259148315954e-08 2134 1.49656169229113 -1.52155006253969 -1 11.1603677255638 2871 4361 4064 4431 2134 3792 3180 3539 3753 4438 3247 4164 M13579 GO_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR.html A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). 122/133 Gene Ontology BP GO:0006289 1.32397143672139e-05 1.53321032729333e-05 700 2928.72727272727 3754 1.20361764047041e-06 697 1.07252951145541 1.15039968093279 1 6.14186722953443 697 4374 4144 4297 3990 1229 739 1795 3754 4569 2628 4165 M15426 GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 1709/2257 Gene Ontology BP GO:0031399 9.68088637418709e-08 4.02645553947883e-07 4225 3031.81818181818 3754 9.68088679592515e-09 1094 1.86609173300707 2.02312752768794 1 14.3297487978615 4225 1302 4556 1946 1094 3754 4286 3985 2703 1254 4245 4166 M12638 GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0034030 0.000169109813471161 0.000179118589137562 2765 3492.09090909091 3758 1.53748012745265e-05 1890 0.93396312597964 -0.987275943683122 -1 4.12924168129583 2763 4274 3758 3994 4371 2527 1890 2698 4361 4070 3707 4167 M13640 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0034033 0.000169109813471161 0.000179118589137562 2765 3489.54545454545 3759 1.53748012745265e-05 1891 0.93396312597964 -0.987275943683122 -1 4.12924168129583 2764 4275 3759 3995 4372 2528 1891 2659 4362 4072 3708 4168 M14952 GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0033866 0.000169109813471161 0.000179118589137562 2765 3494.36363636364 3760 1.53748012745265e-05 1892 0.93396312597964 -0.987275943683122 -1 4.12924168129583 2765 4276 3760 3996 4373 2529 1892 2700 4363 4075 3709 4169 M10195 GO_NUCLEOSOME_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_DISASSEMBLY.html The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. 22/41 Gene Ontology BP GO:0006337 2.13773192862167e-05 2.41487415971756e-05 3180 3365.09090909091 3762 1.94341154651543e-06 955 1.09453745361511 0.968092324038987 1 6.00884643112172 3176 3762 3733 3976 4095 2719 4167 955 4297 3809 2327 4170 M10543 GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-DNA complex into its constituent components. 22/41 Gene Ontology BP GO:0032986 2.13773192862167e-05 2.41487415971756e-05 3180 3364 3763 1.94341154651543e-06 933 1.09453745361511 0.968092324038987 1 6.00884643112172 3177 3763 3734 3977 4096 2720 4168 933 4298 3810 2328 4171 M11257 GO_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOOD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. 13/27 Gene Ontology BP GO:0032094 4.1451582886319e-07 7.79604750081012e-07 4275 3605.63636363636 3763 3.76832642695222e-08 2245 1.10110333470786 -1.05364998534259 -1 8.0310585506726 4274 2245 3345 3763 2425 4246 4123 3114 3963 3605 4559 4172 M14223 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. 13/28 Gene Ontology BP GO:0032695 1.8823941748926e-07 4.84178004188792e-07 4390 3169 3763 1.71126757814237e-08 1728 1.84900119868915 -2.21040245468836 -1 14.0184895030416 4388 2721 2289 3913 1728 3966 4023 2101 4153 1814 3763 4173 M14514 GO_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. 22/26 Gene Ontology BP GO:0030219 1.88611370561058e-06 2.56086579288183e-06 4215 3750.90909090909 3763 1.7146502932944e-07 2700 1.91905807619287 2.18971212211124 1 12.8746381258249 4418 4235 2700 3524 3396 4212 3763 4215 2890 3267 4640 4174 M12941 GO_CHROMATIN_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DISASSEMBLY.html The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. 22/41 Gene Ontology BP GO:0031498 2.13773192862167e-05 2.41487415971756e-05 3180 3462.18181818182 3764 1.94341154651543e-06 1999 1.09453745361511 0.968092324038987 1 6.00884643112172 3178 3764 3735 3978 4097 2721 4169 1999 4299 3815 2329 4175 M13842 GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. 22/25 Gene Ontology BP GO:0090083 0.00357439139969015 0.0036504923579364 2920 3650.72727272727 3764 0.000325473821902029 2761 2.08414828273187 1.92937053384644 1 6.04128991826821 2919 4516 3187 3065 4541 3073 2761 3764 4184 4008 4140 4176 M11832 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS.html The somatic process that results in the generation of sequence diversity of immunoglobulins. 25/29 Gene Ontology BP GO:0016445 3.48952061283064e-05 3.87419217644977e-05 1595 3078.45454545455 3765 3.17234178449278e-06 883 0.915192922084814 1.00304559900064 1 4.78018397458771 1595 3765 3891 3808 4167 1542 883 2871 4269 4242 2830 4177 M15512 GO_TELENCEPHALON_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_REGIONALIZATION.html The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. 5/18 Gene Ontology BP GO:0021978 5.30330776337956e-06 6.55761122057005e-06 4170 3250.27272727273 3765 5.30332041970502e-07 2 2.98266895876345 -3.36524754359412 -1 18.5942426395347 4166 2748 4561 1802 3765 4017 4504 4118 2 3318 2752 4178 M15169 GO_BLASTOCYST_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_GROWTH.html An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. 15/17 Gene Ontology BP GO:0001832 0.000513725410096213 0.000533087496248367 3640 3749.36363636364 3766 4.67132191040737e-05 2987 0.98261394648742 1.14095267382305 1 3.78681894717817 3637 4073 3766 3604 4459 3455 2987 3629 3906 3795 3932 4179 M16158 GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. 98/126 Gene Ontology BP GO:0046467 6.6714556789701e-07 1.09257049337673e-06 4395 3222.72727272727 3766 6.06496154734224e-08 138 1.71731855503734 -1.78294823645236 -1 12.278708688905 4392 138 3083 4101 2796 3941 4172 3766 1639 2933 4489 4180 M13303 GO_TRANSEPITHELIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSEPITHELIAL_TRANSPORT.html The directed movement of a substance from one side of an epithelium to the other. 10/18 Gene Ontology BP GO:0070633 3.17572991076421e-05 3.53847492212305e-05 2465 3410 3769 2.88706886707608e-06 2153 2.22589941360901 -2.47334041556465 -1 11.87961510981 2461 4093 2532 4471 4152 3769 4027 3869 3727 2153 2256 4181 M13470 GO_PROTEIN_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MONOUBIQUITINATION.html Addition of a single ubiquitin group to a protein. 60/65 Gene Ontology BP GO:0006513 5.94971419132468e-06 7.28143612105043e-06 2185 3351.63636363636 3772 5.40884571080466e-07 1860 0.994618394065866 1.08124844917512 1 6.07722399189346 2185 3925 4070 4265 3772 1860 2292 3458 3959 4321 2761 4182 M12745 GO_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. 41/43 Gene Ontology BP GO:0031440 1.88911287738194e-07 4.85369531665278e-07 3775 3542.45454545455 3773 1.71737549054341e-08 1730 1.2901901152162 -0.922855838398497 -1 9.74899471863339 3773 2893 3665 4339 1730 3641 2827 3887 3789 4159 4264 4183 M16046 GO_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORYLATION.html The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. 1131/1444 Gene Ontology BP GO:0016310 7.85545164719405e-08 4.02645553947883e-07 3880 3485.18181818182 3773 7.85545192488059e-09 842 1.72121903131152 1.80943779941069 1 13.2092759076363 3878 3622 4590 3290 842 3284 4299 3924 2755 3773 4080 4184 M16908 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 17/32 Gene Ontology BP GO:0032225 6.01187209684479e-06 7.3521780688334e-06 4045 3134.72727272727 3774 5.46535320487724e-07 731 2.50663325951317 -2.04991113351742 -1 15.4595821366485 4042 3794 2081 2957 3774 4374 3928 2004 731 3018 3779 4185 M10830 GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mitochondrial DNA. 18/18 Gene Ontology BP GO:0032042 3.42722628124496e-05 3.80957570153675e-05 3505 3833.36363636364 3775 3.11570879342998e-06 3361 1.67857066095539 -1.34375940497638 -1 8.86812295412349 3504 4037 3384 4330 4163 4451 4089 3361 3705 3775 3368 4186 M13281 GO_4_HYDROXYPROLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_HYDROXYPROLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. 15/15 Gene Ontology BP GO:0019471 1.7423556106625e-05 1.98754122491116e-05 4420 3549.90909090909 3775 1.58397219083672e-06 1441 1.03742469251808 -0.910058261609383 -1 5.79605059221923 4420 3049 3504 4155 4051 3434 1441 3522 3904 3794 3775 4187 M12711 GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized during embryonic development. 31/43 Gene Ontology BP GO:0048596 6.01955551149901e-06 7.35916757619677e-06 4605 3635.72727272727 3776 5.47233816548974e-07 1878 2.24295049210167 -1.70105302020294 -1 13.8213769525266 4603 3506 1878 2532 3776 4479 4139 4474 3286 3068 4252 4188 M13106 GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION.html Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. 18/20 Gene Ontology BP GO:0000394 2.00123420686293e-05 2.26673387646866e-05 3780 3854.81818181818 3780 1.81932037396364e-06 3076 1.32706716385951 0.871153881851371 1 7.35139908172515 4221 3801 3757 3076 4084 3776 3317 4540 3544 3780 4507 4189 M11207 GO_PROTEASOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ASSEMBLY.html The aggregation, arrangement and bonding together of a mature, active proteasome complex. 15/17 Gene Ontology BP GO:0043248 0.00287415427133351 0.00293986366773243 2995 3608.09090909091 3781 0.000261628731419737 2280 0.554084801720435 0.598982483924576 1 1.59353814127371 2995 4080 3951 3111 4530 2446 2280 3344 4568 4603 3781 4190 M10049 GO_REGULATION_OF_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING_BY_RNA.html Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. 21/27 Gene Ontology BP GO:0060966 0.000377507577501822 0.000394020358482723 2720 3695.72727272727 3783 3.43247610215054e-05 2719 1.44847466788248 -1.42785163219748 -1 5.86094933104818 2719 4514 3783 3829 4436 3599 3025 3325 3968 4251 3204 4191 M11094 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO.html The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. 11/18 Gene Ontology BP GO:0008595 0.000206763725445153 0.000218057936195897 4100 3154.54545454545 3783 1.87984691257611e-05 123 3.11981415099456 -3.04781778437366 -1 13.7119580545979 4100 3592 1837 740 4392 4058 3783 4643 123 2897 4535 4192 M11888 GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS.html Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. 34/50 Gene Ontology BP GO:0044068 4.93272334790663e-06 6.13852948323336e-06 4110 3426.09090909091 3783 4.48430400712007e-07 806 2.06117999821244 2.24032591053405 1 12.88928040576 4108 4209 3235 3276 3715 3783 4438 2094 806 3916 4107 4193 M14898 GO_TRIPARTITE_REGIONAL_SUBDIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIPARTITE_REGIONAL_SUBDIVISION.html Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. 11/18 Gene Ontology BP GO:0007351 0.000206763725445153 0.000218057936195897 4105 3156.18181818182 3784 1.87984691257611e-05 124 3.11981415099456 -3.04781778437366 -1 13.7119580545979 4101 3593 1838 741 4393 4059 3784 4644 124 2905 4536 4194 M15829 GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING.html Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. 21/27 Gene Ontology BP GO:0060147 0.000377507577501822 0.000394020358482723 2720 3689.54545454545 3784 3.43247610215054e-05 2720 1.44847466788248 -1.42785163219748 -1 5.86094933104818 2720 4515 3784 3830 4437 3600 3026 3239 3969 4260 3205 4195 M12436 GO_GLYCOGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. 26/33 Gene Ontology BP GO:0005978 4.5028362578057e-07 8.25845372785571e-07 2995 3487.36363636364 3785 4.09348834492833e-08 2107 0.979722102218146 -0.977806482723918 -1 7.10474650380959 2991 3984 3785 4022 2486 3042 2107 3926 4457 3848 3713 4196 M13753 GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 34/48 Gene Ontology BP GO:0070873 6.75018812572303e-08 4.02645553947883e-07 3970 3408.63636363636 3785 6.13653484803351e-09 525 1.78482702729199 1.93691833636895 1 13.7012321855516 3969 3235 2656 4129 525 4514 4147 3284 3940 3311 3785 4197 M11491 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. 7/21 Gene Ontology BP GO:0002674 0.00361752764607155 0.00369292587476326 3635 3728.18181818182 3786 0.000362343010150663 2911 0.99084116705798 0.884895504854359 1 2.81211231387896 3635 3397 4307 3279 4543 3786 2928 2911 4266 4062 3896 4198 M15244 GO_GLUCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. 26/33 Gene Ontology BP GO:0009250 4.5028362578057e-07 8.25845372785571e-07 2995 3484.63636363636 3786 4.09348834492833e-08 2108 0.979722102218146 -0.977806482723918 -1 7.10474650380959 2992 3985 3786 4023 2487 3043 2108 3884 4458 3851 3714 4199 M10918 GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL.html Any virus-mediated process that modulates the levels of viral proteins in a cell. 15/18 Gene Ontology BP GO:0046719 7.85560299732202e-05 8.46898071050495e-05 1805 2983.81818181818 3790 7.1417122851008e-06 471 0.988821657998733 -1.0303697198006 -1 4.76686050854268 1801 4062 3790 4005 4287 2078 471 2247 4409 4205 1467 4200 M11879 GO_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 40/48 Gene Ontology BP GO:0032069 7.42497332595254e-06 8.92262419567592e-06 3790 3370.27272727273 3790 6.7499985320599e-07 2150 1.4754191016751 1.32915890256108 1 8.90722131480197 3790 4194 3513 2150 3847 2769 2183 2415 3947 3890 4375 4201 M10700 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 1857/2850 Gene Ontology BP GO:0048584 2.03721197671392e-16 1.21527529841665e-14 4400 2822.81818181818 3791 2.03721197671393e-17 48 2.07835184298666 2.19853347068212 1 34.873952638097 4400 1294 4256 1240 768 4474 3827 3791 2648 48 4305 4202 M16127 GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 20/20 Gene Ontology BP GO:0009226 0.00233319786299415 0.0023896917579819 1635 3192.72727272727 3791 0.000212334182122421 1634 1.07184011199848 -1.07213632630466 -1 3.29544670833153 1634 4261 3791 4216 4525 1824 1750 2132 4356 3888 2743 4203 M10185 GO_ANTEROGRADE_AXONAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_AXONAL_TRANSPORT.html The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. 27/32 Gene Ontology BP GO:0008089 2.84664197530093e-05 3.18017409629658e-05 3140 3728.18181818182 3793 2.58788982679148e-06 2977 1.47568449928489 -0.755489235010776 -1 7.92376821423976 3136 4481 3468 3988 4143 3081 3793 2977 3156 4290 4497 4204 M12341 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 18/19 Gene Ontology BP GO:0033160 8.72447255199529e-05 9.3839507129991e-05 3795 3586.45454545455 3793 7.93165323176231e-06 2024 1.64127450151088 1.40612804943657 1 7.89166733169534 3685 4558 3561 2152 4301 3795 3106 2024 4323 4153 3793 4205 M10750 GO_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION.html A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 54/59 Gene Ontology BP GO:0006635 3.12694829672658e-07 6.42946622061751e-07 3795 3778.27272727273 3794 2.84268067379307e-08 2202 1.43166827642093 -0.931551790221531 -1 10.6179137005255 3794 3475 3650 4514 2202 4289 4600 3362 3323 3934 4418 4206 M16609 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_SNRNP_ASSEMBLY.html The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. 39/45 Gene Ontology BP GO:0000387 6.24761998565528e-06 7.60402191819357e-06 390 2832.90909090909 3795 5.67967066171582e-07 389 0.837885692025273 0.9063012736501 1 5.08426897746298 389 4202 4067 4260 3795 962 395 1940 4375 4401 2376 4207 M13851 GO_METHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 18/21 Gene Ontology BP GO:0006555 7.02401883377404e-06 8.46265138103331e-06 1870 3460.54545454545 3799 6.38549205428264e-07 1867 1.11663504511529 1.30660461215797 1 6.74721878808322 1867 4535 3799 4208 3835 3055 2922 2625 3908 3995 3317 4208 M12515 GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 15/25 Gene Ontology BP GO:0070875 3.51271010743198e-06 4.48412623590699e-06 3570 3800 3800 3.19337792376455e-07 2975 1.52380732240925 1.88955291634361 1 9.75340375801991 3570 4055 2975 3800 3619 4362 4087 4143 4475 3469 3245 4209 M15350 GO_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_CAPPING.html Any process that modulates the frequency, rate or extent of telomere capping. 25/26 Gene Ontology BP GO:1904353 1.01218303192352e-05 1.19353462938169e-05 4595 3385 3800 9.20170626215967e-07 112 1.88754911793782 -1.74214417967125 -1 11.1356278776711 4595 3990 2903 2336 3920 4016 3533 4247 112 3800 3783 4210 M16501 GO_RESPONSE_TO_UV_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_B.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. 16/19 Gene Ontology BP GO:0010224 1.28919342215461e-06 1.83668615838499e-06 4315 3663.36363636364 3800 1.1719947069261e-07 2279 1.67941399203533 -1.3342832111265 -1 11.5472393091214 4313 3800 2912 3932 3232 4413 3482 2279 4629 3240 4065 4211 M12198 GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 30/38 Gene Ontology BP GO:0044275 0.0780333164067599 0.0784887637787838 2665 3642.54545454545 3801 0.0073588077696682 2664 1.1231282241721 0.805110005101515 1 1.39823434960916 2664 3979 3787 4008 4611 2890 2727 4358 2900 4343 3801 4212 M11997 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. 442/608 Gene Ontology BP GO:0032388 9.33573997786724e-08 4.02645553947883e-07 4445 3518.63636363636 3802 8.48703670366459e-09 921 1.70746808369268 1.8053309036507 1 13.1029234765607 4443 3116 3482 3336 921 4322 4121 4419 2354 3802 4389 4213 M12056 GO_PEPTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 554/740 Gene Ontology BP GO:0006518 2.73363840075785e-07 5.85887585385825e-07 2825 3797.27272727273 3803 2.73363873703296e-08 2179 1.24965568704275 -1.23802105287517 -1 9.31593308130778 2825 4616 4340 4635 2179 3969 3421 3617 3751 4614 3803 4214 M14680 GO_RESPONSE_TO_YEAST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_YEAST.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. 11/22 Gene Ontology BP GO:0001878 0.0119815815969431 0.0121433890591541 3795 3541.45454545455 3804 0.00109521248015943 1869 2.49658200447944 2.03169476348378 1 5.68110896268149 3795 4580 1869 4341 4570 2654 2701 3804 4233 2384 4025 4215 M14828 GO_MEMBRANE_HYPERPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_HYPERPOLARIZATION.html The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. 8/21 Gene Ontology BP GO:0060081 5.88471145818656e-06 7.21136750459364e-06 4445 3621.63636363636 3805 5.88472704166767e-07 1981 1.97125493652451 -2.29093868598268 -1 12.1556849054433 4442 3393 4518 3063 3810 3805 1981 3267 4077 3331 4151 4216 M11372 GO_ORGANOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. 809/1043 Gene Ontology BP GO:0019637 6.44753535811171e-08 4.02645553947883e-07 4005 3484.63636363636 3806 6.4475355451799e-09 582 1.6581528021202 -1.69557216318528 -1 12.7215097565909 4003 3111 4295 4299 582 4349 4100 3428 2588 3806 3770 4217 M12236 GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION.html A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. 15/31 Gene Ontology BP GO:0072378 7.40156220025965e-06 8.89678866386157e-06 3810 3231.09090909091 3807 6.72871554708771e-07 1653 2.48203628402535 2.29489424111049 1 15.0582725611395 2380 3808 1653 4317 3846 2180 2367 4511 4007 2666 3807 4218 M12247 GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. 13/14 Gene Ontology BP GO:0045898 0.00111864293938287 0.00115155876038683 1085 2759.18181818182 3807 0.000101746558685648 416 1.0989510514581 1.0989510514581 1 3.802794214184 1082 4084 3807 4229 4517 1024 416 1325 4333 3896 1638 4219 M16786 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. 18/19 Gene Ontology BP GO:1990440 1.72585233493872e-05 1.96968136239143e-05 3960 3582.09090909091 3809 1.56896897638642e-06 2183 2.7683078175668 3.62236226201129 1 15.6513297331753 3957 4035 2183 3294 4049 4286 3619 3812 2576 3783 3809 4220 M11965 GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. 20/22 Gene Ontology BP GO:1903894 0.00109069873592301 0.00112328933560198 2235 3428.18181818182 3811 9.92036226906586e-05 2003 1.00125297094949 0.972546255735648 1 3.46863928396813 2234 4540 3811 4071 4497 2204 2068 2003 4635 4336 3311 4221 M11982 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 37/45 Gene Ontology BP GO:0071353 7.28058280224859e-06 8.76042197539765e-06 3095 3670.18181818182 3811 6.61873354218117e-07 2677 1.81686614612886 -1.57842788837159 -1 11.0098981532563 3092 4456 2983 4188 3841 3603 2677 4395 4214 3112 3811 4222 M14198 GO_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MIGRATION.html The movement of a T cell within or between different tissues and organs of the body. 16/27 Gene Ontology BP GO:0072678 1.12921707886962e-05 1.32082631170949e-05 4110 3256.45454545455 3811 1.02656624996567e-06 1175 2.10215173856647 1.51536871075241 1 12.301495335487 4110 3322 2209 3001 3957 4290 3934 1175 3811 1544 4468 4223 M15105 GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 238/306 Gene Ontology BP GO:0009123 6.31037333331368e-07 1.05263043393331e-06 1310 3415.18181818182 3811 5.73670467577389e-08 1308 1.30588401066492 1.24345049545731 1 9.33785701830193 1308 4639 4132 4590 2747 2569 1951 3811 3485 4505 3830 4224 M15554 GO_RENAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_ABSORPTION.html A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). 18/35 Gene Ontology BP GO:0070293 8.48804210857129e-07 1.31474234125107e-06 4065 3532.90909090909 3812 7.71640489402751e-08 1809 3.30157691214183 -3.84784482486968 -1 23.3800312435249 3473 4260 1809 4480 2963 4315 4062 4062 3812 2765 2861 4225 M11964 GO_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PROCESSING.html Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. 857/1051 Gene Ontology BP GO:0006396 4.62027389064056e-06 5.78062232136341e-06 2490 3860.09090909091 3814 4.62028349678754e-07 2489 0.927660506085463 0.971263368630866 1 5.77363606986816 2489 4607 4335 4652 3724 3148 3027 3814 4307 4612 3746 4226 M15250 GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME.html The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. 19/23 Gene Ontology BP GO:0045292 9.38523001349828e-05 0.000100760210551009 2850 3634.27272727273 3815 8.53239128418614e-06 2410 0.853249388210569 0.970454911533039 1 4.02131832423967 2849 3797 3939 3815 4309 2865 2410 3933 4347 4322 3391 4227 M11926 GO_INTRA_S_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_S_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. 11/13 Gene Ontology BP GO:0031573 0.00129616394013575 0.0013319458510273 2320 3337.18181818182 3817 0.000117902565963506 1134 0.903575569784938 0.903575569784938 1 3.03935120913301 2317 4321 3817 4037 4507 2190 1134 2923 4550 4244 2669 4228 M15049 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. 65/76 Gene Ontology BP GO:0072332 1.88005419215848e-05 2.13675919787822e-05 4205 3760.36363636364 3817 1.70915478066496e-06 3090 1.92588406929158 2.10905863606073 1 10.7747843666568 4201 4412 3351 3090 4070 4061 3817 3497 3299 4151 3415 4229 M12433 GO_RNA_SURVEILLANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SURVEILLANCE.html The set of processes involved in identifying and degrading defective or aberrant RNAs. 14/14 Gene Ontology BP GO:0071025 1.66367876536225e-05 1.90252903433564e-05 1750 3216.27272727273 3820 1.51244667866129e-06 1016 0.728613509035883 0.800071711089443 1 4.05681635237526 1746 4074 3845 3820 4040 2033 1016 2844 4405 4328 3228 4230 M13797 GO_RESPONSE_TO_AUDITORY_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AUDITORY_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. 30/48 Gene Ontology BP GO:0010996 6.66822929472279e-06 8.06322009052628e-06 4465 3385.36363636364 3820 6.06204500572758e-07 1654 2.25528935005462 -2.04398270248204 -1 13.7897487834006 4463 2935 1654 3900 3820 4591 3854 2854 3562 1679 3927 4231 M16761 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 35/43 Gene Ontology BP GO:1902175 5.31248582943452e-08 4.02645553947883e-07 4490 3447.54545454545 3821 4.82953268883514e-09 293 1.04537486992661 1.20337204151869 1 7.98216926859464 4490 2907 3801 1886 293 4601 4353 4082 3081 3821 4608 4232 M16819 GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 50/55 Gene Ontology BP GO:0010823 1.40028931219211e-05 1.61716211705879e-05 3590 3675.63636363636 3821 1.27299838640452e-06 2793 1.37869850555933 1.80844815547985 1 7.88593924478588 3590 4180 3717 3842 4003 2793 2895 3380 4172 4039 3821 4233 M10139 GO_RESPONSE_TO_UV_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_C.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. 12/13 Gene Ontology BP GO:0010225 8.76622680630188e-05 9.42668207296572e-05 1115 2827.54545454545 3822 7.96961466283475e-06 631 0.801795168640995 0.801795168640995 1 3.80066191379303 1112 4583 3822 4530 4302 1244 636 631 4296 4274 1673 4234 M11004 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 14/18 Gene Ontology BP GO:0060261 0.00058397196859491 0.000605306654014728 695 2766.72727272727 3825 5.31024578906328e-05 481 1.21805801368281 1.21805801368281 1 4.63756605623611 693 4566 3825 4235 4556 1062 481 1106 4360 3973 1577 4235 M15653 GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE.html The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. 42/47 Gene Ontology BP GO:0042769 3.45589249808195e-05 3.83777274309674e-05 1255 3207.72727272727 3827 3.14176980592417e-06 1253 1.0939337970765 1.06151497706178 1 5.73930811438131 1253 3965 3949 3827 4165 1893 2075 2457 4372 4104 3225 4236 M16903 GO_PIGMENT_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_METABOLIC_PROCESS.html The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. 52/73 Gene Ontology BP GO:0042440 2.52444263620272e-07 5.63098350251739e-07 3935 3433.72727272727 3829 2.29494811443271e-08 1628 1.47568545408754 1.38474179083448 1 11.0503123982675 3933 1914 3284 4468 2025 4579 4641 3369 1628 4101 3829 4237 M12370 GO_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_SIGNAL_TRANSDUCTION.html The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. 1551/2025 Gene Ontology BP GO:0035556 4.82011771108595e-08 4.02645553947883e-07 4595 2928.63636363636 3830 4.82011781563685e-09 289 1.88527814781919 2.0246049385588 1 14.4781401608027 4591 1306 4365 1463 289 4422 3830 4551 2441 309 4648 4238 M13428 GO_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRAND_BREAK_REPAIR.html The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. 158/195 Gene Ontology BP GO:0006302 1.27828211562848e-05 1.48547619481002e-05 700 2691 3830 1.16208140271374e-06 339 1.26701455365753 1.48913510225306 1 7.29530843099388 698 4129 4122 4073 3975 339 419 1973 3830 4359 1684 4239 M16056 GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. 107/124 Gene Ontology BP GO:0048524 1.84846459623226e-07 4.78093705740338e-07 3835 3561.09090909091 3831 1.68042250140212e-08 1716 1.31303656678009 -1.38682086877017 -1 9.93386764893047 3831 3167 3944 3974 1716 4412 3290 3867 3399 4096 3476 4240 M10673 GO_ENERGY_RESERVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_RESERVE_METABOLIC_PROCESS.html The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. 67/89 Gene Ontology BP GO:0006112 1.55791878778561e-07 4.41300019561337e-07 3470 3701.18181818182 3832 1.41628990737168e-08 1550 1.23339091498161 1.30491896360055 1 9.37693641877553 3470 4160 3832 4059 1550 3758 3559 4208 4137 4200 3780 4241 M13823 GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. 184/225 Gene Ontology BP GO:0006352 2.55601429442836e-07 5.65745344301423e-07 3380 3532.81818181818 3832 2.32364962853859e-08 1968 1.20231103149444 1.09474628610254 1 8.98117963123132 3379 4353 4148 4283 2041 1968 2304 4345 3832 4497 3711 4242 M14334 GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 23/32 Gene Ontology BP GO:0071236 0.00113179164117971 0.00116483665260102 4180 3528.09090909091 3832 0.000102943119266781 1329 2.71339403996699 3.12028019710904 1 9.52430339141401 4176 4250 2596 2814 4511 4525 3742 1329 3172 3862 3832 4243 M15111 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. 10/14 Gene Ontology BP GO:0033033 6.98378904619348e-06 8.42072309715943e-06 3980 3624.81818181818 3832 6.34891928725283e-07 3038 1.54928732549307 1.17286509815334 1 9.40543521941039 3976 3850 3045 3038 3832 4222 3864 3636 3378 3192 3840 4244 M12501 GO_METALLO_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLO_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. 21/22 Gene Ontology BP GO:0031163 1.92799842551729e-06 2.61011832235437e-06 1895 3432.45454545455 3833 1.75272737740518e-07 1568 1.09814346417302 -1.23025513528414 -1 7.31222993793345 1892 4010 3833 4352 3405 3586 4108 1568 4149 4254 2600 4245 M12000 GO_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule. 45/83 Gene Ontology BP GO:0070988 9.04987008629762e-07 1.38516597077443e-06 3005 3749.54545454545 3834 8.22715800821252e-08 3001 1.34671680599736 1.18627096386655 1 9.43887032534295 3646 4184 3585 4376 3001 4096 4119 3005 3223 4176 3834 4246 M13758 GO_IRON_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. 21/22 Gene Ontology BP GO:0016226 1.92799842551729e-06 2.61011832235437e-06 1895 3431.09090909091 3834 1.75272737740518e-07 1541 1.09814346417302 -1.23025513528414 -1 7.31222993793345 1893 4011 3834 4353 3406 3587 4109 1541 4150 4257 2601 4247 M15433 GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification. 53/71 Gene Ontology BP GO:1903309 1.38372317941298e-05 1.59882392694527e-05 2760 3535.90909090909 3834 1.25793807511385e-06 2394 1.24566193832571 1.38748699678872 1 7.12251767612267 2759 3936 3955 3112 4000 3665 4177 2950 3834 4113 2394 4248 M12862 GO_PROTEIN_O_LINKED_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_MANNOSYLATION.html The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. 16/16 Gene Ontology BP GO:0035269 2.1570069516583e-05 2.43546550499056e-05 2745 3580.09090909091 3835 1.9609346368086e-06 2106 1.03323519245651 1.25456662457095 1 5.66193196538515 2745 4554 3835 4384 4099 3328 2885 2106 4240 4235 2970 4249 M13239 GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. 322/377 Gene Ontology BP GO:1903320 2.09090187697745e-07 5.0487630687992e-07 3840 3610.54545454545 3837 1.90082006881715e-08 1852 1.3076533419152 1.32613149436519 1 9.85528182502012 3837 3878 4127 3643 1852 2884 3450 4226 3302 4383 4134 4250 M16483 GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. 59/79 Gene Ontology BP GO:0006521 0.0184766983515349 0.0186814596761608 2590 3584.09090909091 3838 0.00169397493781975 2360 0.952808529887598 0.875728902248622 1 1.8889371930832 2587 3930 4091 3838 4583 2596 2360 3690 3338 4391 4021 4251 M13443 GO_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAPPING.html The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. 38/43 Gene Ontology BP GO:0036260 0.000114144298544135 0.000121703350395477 1375 3327.63636363636 3840 1.0377292837374e-05 1373 0.768104538049625 0.805591123580952 1 3.53357530555161 1373 3972 4089 3840 4335 2152 1836 2758 4397 4498 3354 4252 M14706 GO_RRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an rRNA molecule. 13/14 Gene Ontology BP GO:0031125 0.000120001492751095 0.000127860532578623 1025 3143.81818181818 3840 1.09098217153077e-05 598 0.680200156931928 0.680200156931928 1 3.09976635221543 1025 4306 3840 4028 4341 1705 598 2521 4530 4632 3056 4253 M11819 GO_REGULATION_OF_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_BINDING.html Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 25/33 Gene Ontology BP GO:0035561 2.45383375848442e-05 2.75789576768792e-05 3585 3829.90909090909 3841 2.23078284405253e-06 2447 1.00605948720406 1.21820577623123 1 5.44460817185463 3581 3994 3754 4368 4117 3841 3623 3661 4335 4408 2447 4254 M14394 GO_7_METHYLGUANOSINE_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_7_METHYLGUANOSINE_RNA_CAPPING.html The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. 38/43 Gene Ontology BP GO:0009452 0.000114144298544135 0.000121703350395477 1375 3328 3841 1.0377292837374e-05 1374 0.768104538049625 0.805591123580952 1 3.53357530555161 1374 3973 4090 3841 4336 2153 1837 2752 4398 4499 3355 4255 M10774 GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 27/30 Gene Ontology BP GO:0033158 0.00281204507299343 0.00287696695792402 4095 3665.63636363636 3844 0.000255967807338616 2422 1.38017760527656 1.40358069061193 1 4.1385452344992 4094 4497 3844 2631 4529 3598 2422 2430 4329 4291 3657 4256 M16565 GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of establishment of protein localization. 600/851 Gene Ontology BP GO:1904951 8.09690962780365e-08 4.02645553947883e-07 4285 3087.27272727273 3845 8.09690992282343e-09 868 1.92173862986176 2.0260295826751 1 14.7601324286014 4284 1420 4636 1837 868 4584 3970 3845 1943 1985 4588 4257 M16744 GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION.html A cellular localization which involves only one organism. 1005/1309 Gene Ontology BP GO:1902580 1.13635003264607e-07 4.06950048332718e-07 4645 3557.54545454545 3846 1.13635009075418e-08 1292 1.70379384873646 -1.41229512280356 -1 13.0649901598707 3974 3623 4645 3278 1292 3846 3015 4641 1999 4388 4432 4258 M13244 GO_COVALENT_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COVALENT_CHROMATIN_MODIFICATION.html The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. 342/403 Gene Ontology BP GO:0016569 2.077905973866e-06 2.7927488435582e-06 3455 3818.63636363636 3848 1.88900721496039e-07 3256 1.16403366202736 1.22761721055332 1 7.71580309043196 3452 4343 4203 4091 3433 3294 3256 3848 3917 4554 3614 4259 M12786 GO_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FISSION.html The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 14/15 Gene Ontology BP GO:0000266 0.000436698074284471 0.000453865566148234 3130 3814.36363636364 3849 3.97077075060951e-05 1972 0.829567617587963 -0.568020575578866 -1 3.25106978645412 3126 3823 3849 4394 4454 3253 1972 4618 4566 4167 3736 4260 M12918 GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. 80/90 Gene Ontology BP GO:0006368 5.54213418240521e-05 6.0434849661897e-05 1350 3256.72727272727 3849 5.03843072918907e-06 1346 0.779558084079005 0.792659258622746 1 3.87442530621856 1346 3917 4164 3849 4240 1879 1661 2971 4359 4542 2896 4261 M13959 GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 20/23 Gene Ontology BP GO:1900103 0.00415605688836731 0.00424081857490638 3850 3912.45454545455 3849 0.000378538999350864 2800 1.1489117890835 1.07367176045262 1 3.19367917593483 3849 4534 3692 3839 4544 3462 2800 3278 4619 4225 4195 4262 M10199 GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. 94/104 Gene Ontology BP GO:0006354 5.75378354837274e-05 6.26840431996683e-05 1425 3243.63636363636 3851 5.23084912346839e-06 1425 0.768685120144556 0.785108553867389 1 3.80419729529397 1425 3913 4181 3851 4243 1870 1682 2645 4418 4566 2886 4263 M13102 GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS.html Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 167/252 Gene Ontology BP GO:0010565 3.87908135784545e-06 4.90872057602798e-06 3150 3840.81818181818 3851 3.52644381593773e-07 3137 1.51212712576857 -1.42537165336115 -1 9.60600040668972 3147 4650 3851 3353 3651 4454 4505 4149 3137 4054 3298 4264 M10862 GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. 81/87 Gene Ontology BP GO:0006283 0.000124694511629895 0.000132739318831824 985 3202.63636363636 3852 1.1336507253757e-05 983 0.765407834593437 0.821143592530186 1 3.48591247740217 983 4405 4169 3852 4346 1673 1115 2594 4542 4555 2995 4265 M11544 GO_PROTEIN_LOCALIZATION_TO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CENTROSOME.html A process in which a protein is transported to, or maintained at, the centrosome. 22/22 Gene Ontology BP GO:0071539 2.73761841148603e-07 5.86249303175147e-07 4325 3797 3852 2.48874432013423e-08 2112 1.17386645868863 -1.15515560416779 -1 8.74431482215362 4321 3769 3664 4346 2112 3852 3094 4016 4179 3811 4603 4266 M15746 GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 369/495 Gene Ontology BP GO:0072521 8.54287877707694e-08 4.02645553947883e-07 1935 3210.90909090909 3852 7.7662537352798e-09 818 1.58693249882489 1.52166944790339 1 12.1706784533706 1933 4118 3961 4503 818 2685 2412 4147 2688 4203 3852 4267 M16526 GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 8/17 Gene Ontology BP GO:0043950 0.00903675115336566 0.00916877521077419 3160 3744.09090909091 3853 0.000907371115383849 2089 1.71677290140363 -2.1773913107501 -1 4.12781487803781 3159 4593 4631 4520 4615 3853 2203 2089 4310 3798 3414 4268 M11077 GO_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 172/281 Gene Ontology BP GO:0006413 6.0187144925135e-05 6.54477180034244e-05 865 3273.63636363636 3854 5.47170832506042e-06 847 0.667328301274466 -0.557532143750312 -1 3.27388760818858 862 4371 4189 3854 4249 1957 847 3254 4625 4600 3202 4269 M14369 GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. 16/19 Gene Ontology BP GO:0036499 0.0141531659272862 0.0143318130706557 3730 3836.09090909091 3854 0.00129500413417078 2819 1.89623525690087 -2.51513754210665 -1 4.12520027307825 3726 4068 3143 2819 4575 4200 3631 3621 4354 3854 4206 4270 M12504 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY.html The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. 14/14 Gene Ontology BP GO:0000244 0.00100733664544372 0.00103858573260572 2805 3664.27272727273 3857 9.16180164480714e-05 2411 0.879359832892267 1.07661204042213 1 3.0700421677706 2804 4567 3857 4517 4491 3039 2411 3551 4022 4166 2882 4271 M16759 GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA.html The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. 25/29 Gene Ontology BP GO:0070918 2.91522264637084e-06 3.77860507075592e-06 3425 3881.09090909091 3857 2.65020591758458e-07 3082 0.957452307406913 1.01406877044395 1 6.17616845512515 3423 4246 3970 4274 3564 3527 3082 3832 4577 4340 3857 4272 M14464 GO_DSRNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DSRNA_FRAGMENTATION.html Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. 25/29 Gene Ontology BP GO:0031050 2.91522264637084e-06 3.77860507075592e-06 3860 3882.72727272727 3860 2.65020591758458e-07 3081 0.957452307406913 1.01406877044395 1 6.17616845512515 3422 4245 3969 4273 3563 3526 3081 3860 4576 4339 3856 4273 M12241 GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS.html The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. 236/275 Gene Ontology BP GO:0090305 5.08094295576681e-07 8.9382334870257e-07 2670 3508.36363636364 3861 4.61904011747354e-08 1759 1.20825909966676 1.10634933389643 1 8.73586847078472 2669 4640 4175 4602 2598 2025 1759 3861 3837 4524 3902 4274 M13358 GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. 1798/2297 Gene Ontology BP GO:0006796 6.3060010398099e-08 4.02645553947883e-07 4540 3554.90909090909 3861 6.30600121875533e-09 560 1.71747243738026 1.77754451567903 1 13.1802990411768 4539 3106 4423 3861 560 3477 4359 4145 2729 3542 4363 4275 M14939 GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. 15/15 Gene Ontology BP GO:0043558 0.0153222701586578 0.0154988093583119 4585 3446.81818181818 3862 0.00140273063152034 1980 1.32467965184326 -1.32467965184326 -1 2.79630017732845 1980 4581 3862 4550 4581 2661 2034 2250 4454 4351 2611 4276 M15562 GO_PROTEIN_REFOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_REFOLDING.html The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. 26/28 Gene Ontology BP GO:0042026 7.87068322590309e-06 9.41931302729606e-06 2580 3640.36363636364 3863 7.15519216733533e-07 2386 0.8681229429393 1.10437183272085 1 5.17384745503487 2579 4519 3958 4594 3863 2823 2386 3095 4645 4355 3227 4277 M12155 GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. 478/568 Gene Ontology BP GO:0010608 6.40474808464452e-07 1.06547346577944e-06 3625 3941.27272727273 3864 5.82249995384274e-08 2755 1.31699310302123 1.33369271680019 1 9.40978091801568 3624 4619 4198 4638 2755 3362 3724 3864 3684 4591 4295 4278 M14563 GO_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. 653/787 Gene Ontology BP GO:0007005 2.94911183105552e-07 6.17006175804915e-07 2625 3572.27272727273 3865 2.94911222243231e-08 2230 1.5167889869679 1.5422645273154 1 11.2881386566354 2624 4610 4501 4628 2230 2659 2259 3865 3166 4582 4171 4279 M16299 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE.html The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. 24/57 Gene Ontology BP GO:0001990 4.96830520286389e-08 4.02645553947883e-07 4265 2788.36363636364 3865 4.51664119551286e-09 245 2.21312257648246 1.98197280331539 1 17.0137510124628 4265 867 1116 3865 245 4393 1799 4396 4169 1189 4368 4280 M12532 GO_SECRETORY_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. 33/40 Gene Ontology BP GO:0033363 3.42249364713073e-06 4.38098017609333e-06 3610 3787 3866 3.11136270131235e-07 2669 1.51645667106445 -0.779405808141434 -1 9.7243933173159 4172 4213 3515 4365 3610 3585 2669 4101 3954 3866 3607 4281 M15812 GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE.html Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. 13/23 Gene Ontology BP GO:0051969 1.94610911870984e-05 2.2059063896119e-05 3600 3651.09090909091 3866 1.76920575828004e-06 1942 2.90821100717787 2.64228702145246 1 16.2744969954639 3600 4294 1942 3925 4081 3802 3516 4448 3898 2790 3866 4282 M10753 GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. 29/36 Gene Ontology BP GO:0045932 2.06316728868338e-05 2.33404264387157e-05 4530 3443.63636363636 3867 1.87562421580782e-06 1276 2.1685485783647 1.98810833772671 1 12.0448109526062 4527 3250 2071 3443 4091 3933 4058 3989 3375 1276 3867 4283 M15922 GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX.html The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. 13/16 Gene Ontology BP GO:0030150 0.00224221839874241 0.00229701501746993 885 3197.72727272727 3867 0.000204046082889732 881 0.656468332360415 0.656468332360415 1 1.99209618492369 881 4089 3867 4381 4524 1594 1274 2491 4571 4644 2859 4284 M15485 GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. 146/170 Gene Ontology BP GO:0051053 8.11359475016698e-06 9.6950581336741e-06 2845 3804.54545454545 3868 7.37602243021778e-07 2843 1.45490976050278 1.68966409554349 1 8.71852758803751 2843 4363 4015 4591 3868 3317 3058 4139 3743 4390 3523 4285 M15362 GO_NUCLEOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPHAGY.html A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. 18/20 Gene Ontology BP GO:0044804 0.000195481406282168 0.000206393234270689 1195 2708.36363636364 3869 1.77726161799685e-05 315 1.04015002576319 -1.18408403041944 -1 4.53298828521853 1192 4047 3869 4029 4388 1194 626 1902 4075 4155 315 4286 M11015 GO_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_PROCESSING.html Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. 435/527 Gene Ontology BP GO:0006397 8.27644628164503e-06 9.87950347575535e-06 1455 3451.81818181818 3872 7.5240703799764e-07 1451 1.05106497662143 1.03584962599955 1 6.2595106274921 1451 4623 4188 4643 3872 2311 1622 3392 4092 4599 3177 4287 M12503 GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 9/107 Gene Ontology BP GO:0048387 0.000137465798957802 0.000146067221409146 3550 3734.72727272727 3872 1.37474303278859e-05 2518 1.12073657075878 -1.17828338230933 -1 5.09566809345693 3548 4103 4372 4349 4364 3369 3472 2518 3994 3872 3121 4288 M13899 GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. 145/173 Gene Ontology BP GO:0006367 2.78786286540837e-07 5.94224732603992e-07 3870 3633.63636363636 3872 2.53442110789937e-08 2062 1.21596418241508 1.0256045712807 1 9.05296971684781 3869 4131 4103 4582 2125 2062 2540 3810 3872 4382 4494 4289 M10796 GO_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. 1260/1734 Gene Ontology BP GO:0051336 9.76310814724627e-09 1.62823448778268e-07 4545 2823.45454545455 3873 9.76310819013948e-10 156 2.01452358024881 2.17548809887721 1 16.4357398515644 4544 1323 4263 671 513 4404 3873 4108 2577 156 4626 4290 M12335 GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 34/35 Gene Ontology BP GO:0009225 0.000233864068149639 0.00024613650963589 4210 3251.09090909091 3873 2.1262630184811e-05 1865 1.19572718307334 -1.15650835447883 -1 5.11579601161447 1865 4208 3873 4206 4403 2067 2044 2008 4070 3917 3101 4291 M14623 GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of monocyte differentiation. 11/19 Gene Ontology BP GO:0045655 8.28108263469523e-06 9.88250256456448e-06 4505 3724.45454545455 3873 7.52828527810764e-07 1867 1.61646888796589 1.61143155693579 1 9.68184298397656 4505 3843 2992 3498 3873 4506 3486 4229 4186 1867 3984 4292 M14906 GO_URATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. 9/18 Gene Ontology BP GO:0046415 0.000644134347404133 0.000667221086035492 4470 3864 3874 6.44321132683894e-05 3097 1.36207569914052 -1.85579624886515 -1 5.12839318211224 4469 3391 4524 3768 4473 3965 3692 3145 3097 3874 4106 4293 M11969 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. 497/647 Gene Ontology BP GO:0055086 6.50078399413714e-08 4.02645553947883e-07 2305 3211.45454545455 3875 5.90980380566265e-09 482 1.59674010772591 1.56246231061498 1 12.246532356576 2305 3875 3983 4473 482 2738 2557 4036 2629 4187 4061 4294 M13105 GO_MATURATION_OF_LSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_LSU_RRNA.html Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. 14/17 Gene Ontology BP GO:0000470 0.000242788879339175 0.00025529867922377 2005 3537 3876 2.20741524832673e-05 2005 0.815806567796204 0.883497010941348 1 3.44197130273611 2005 4083 3876 4036 4406 2457 2622 3182 4539 4329 3372 4295 M11294 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 17/18 Gene Ontology BP GO:0033145 0.000192900723349422 0.000203714722139097 4005 3294.45454545455 3878 1.75379672159602e-05 45 2.38836611446854 2.43230420206731 1 10.5583705334408 4002 3351 2981 1864 4387 3878 3978 3388 45 3919 4446 4296 M11908 GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). 20/31 Gene Ontology BP GO:1901071 0.273382219134099 0.274148160696328 3560 3984.45454545455 3881 0.0286148577489564 3122 1.41220539422166 1.45794973209977 1 0.856916851800591 3557 4545 3713 3620 4633 3719 4182 4627 4230 3881 3122 4297 M12337 GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS.html The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. 218/269 Gene Ontology BP GO:0015980 2.42986179305563e-07 5.50981818863931e-07 1665 3540.54545454545 3882 2.20896551039063e-08 1664 1.03945502561458 1.0590779690472 1 7.76514707315678 1664 4645 4199 4626 1989 2696 2683 3844 4141 4577 3882 4298 M15283 GO_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING.html Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. 58/107 Gene Ontology BP GO:0006342 2.29369680517938e-05 2.58415768389822e-05 1965 2750.90909090909 3884 2.08520065397227e-06 32 1.15787583062477 1.23612029133609 1 6.32131847566422 1963 4416 3884 4402 4108 845 1476 686 4220 4228 32 4299 M13445 GO_LIVER_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIVER_REGENERATION.html The regrowth of lost or destroyed liver. 20/26 Gene Ontology BP GO:0097421 0.00823819661942505 0.00836220088791116 3495 3878.27272727273 3885 0.000751746214398367 2888 1.46400986350137 -1.45916223313061 -1 3.57571826921358 3492 4502 3493 4165 4565 4310 3867 4012 2888 3885 3482 4300 M14408 GO_CELLULAR_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 45/62 Gene Ontology BP GO:0071359 2.71618055467119e-08 3.62131464781807e-07 3240 3512.72727272727 3885 2.46925508018719e-09 45 1.30544138640332 -1.41901148269977 -1 10.0662870325934 3240 4188 3885 4587 45 3427 3241 3971 4330 4177 3549 4301 M15413 GO_NUCLEAR_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXPORT.html The directed movement of substances out of the nucleus. 177/222 Gene Ontology BP GO:0051168 8.77857801367172e-06 1.04440612369252e-05 1255 3211.72727272727 3885 7.98055731154555e-07 1152 0.976059703207011 0.903687651018975 1 5.77698797283177 1251 4128 4209 4092 3885 1906 1152 2740 4365 4561 3040 4302 M16259 GO_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. 1673/2309 Gene Ontology BP GO:0009056 9.46972220123903e-08 4.02645553947883e-07 3430 3706.72727272727 3885 9.46972260477942e-09 1063 1.67444728535237 -1.52423923627904 -1 12.8475343734316 3430 4598 4609 4515 1063 3642 3384 4311 2850 4487 3885 4303 M16969 GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. 19/23 Gene Ontology BP GO:0031998 2.3634198398089e-05 2.66013365133788e-05 3760 3763.36363636364 3885 2.14858657270788e-06 2874 1.83820127931647 1.91680028979963 1 10.0680113432266 3759 4019 2874 3254 4111 3677 3885 4431 3902 3261 4224 4304 M11488 GO_MICROTUBULE_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_NUCLEATION.html The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). 21/24 Gene Ontology BP GO:0007020 5.10797990197251e-05 5.59233658444191e-05 3765 3878.36363636364 3887 4.64372591215196e-06 3326 0.84811536080762 -0.727320316644889 -1 4.25877173909844 3764 3539 3887 3326 4223 4476 3500 3905 4338 4252 3452 4305 M10289 GO_NCRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). 21/26 Gene Ontology BP GO:0034661 2.86991999070473e-06 3.72489197119919e-06 2570 3402.81818181818 3890 2.60902157686206e-07 921 0.837442224278981 0.795979002577626 1 5.39542043603893 2567 4252 3890 4375 3559 2041 921 3984 4473 4121 3248 4306 M16710 GO_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 154/182 Gene Ontology BP GO:0042542 1.05380945140661e-06 1.55366773681715e-06 4360 3744.81818181818 3890 9.58009051078362e-08 2613 1.8382209820756 1.96585609742676 1 12.8104637501007 4360 3890 2613 3636 3119 4218 4301 4405 3560 2856 4235 4307 M14255 GO_CELLULAR_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCOSE_HOMEOSTASIS.html A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. 81/105 Gene Ontology BP GO:0001678 1.96142014997594e-07 4.93246485651519e-07 3895 3730.81818181818 3892 1.7831093862248e-08 1770 1.45312813554876 1.59519867120502 1 10.9809102123659 3892 4395 3761 4417 1770 3523 2710 4248 4019 3691 4613 4308 M10852 GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT.html The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. 15/16 Gene Ontology BP GO:0099514 0.000793904690760903 0.000820897450246773 1720 3339.27272727273 3894 7.21992116918755e-05 1718 0.720236575321983 -0.720236575321983 -1 2.58485763655368 1718 4577 3894 4406 4474 1979 1878 2216 4642 4597 2351 4309 M15752 GO_HETEROCHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. 11/13 Gene Ontology BP GO:0070828 1.08916553760474e-06 1.5921731845664e-06 3895 3671.09090909091 3894 9.90150978930917e-08 2906 1.27266423916513 -1.5085574630712 -1 8.82108794823099 3894 3081 3168 3919 3149 4158 3225 4282 4086 2906 4514 4310 M10810 GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 984/1413 Gene Ontology BP GO:0045937 3.50327381874112e-10 7.95157711151339e-09 4605 2839.72727272727 3895 3.5032738192934e-11 118 2.08688038373131 2.23669772477419 1 20.3392256675497 4605 1348 4264 707 565 4417 3895 4363 2707 118 4248 4311 M11261 GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT.html The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. 15/16 Gene Ontology BP GO:0048490 0.000793904690760903 0.000820897450246773 1720 3354 3895 7.21992116918755e-05 1719 0.720236575321983 -0.720236575321983 -1 2.58485763655368 1719 4578 3895 4407 4475 1980 1879 2361 4643 4605 2352 4312 M12982 GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. 25/32 Gene Ontology BP GO:0090049 9.18841182875098e-06 1.08982106141163e-05 4340 3808.72727272727 3895 8.35313654985858e-07 3086 1.39920211057206 1.42856150064174 1 8.29478662892549 4339 3747 3122 3086 3895 4262 4205 4454 3191 3286 4309 4313 M11922 GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. 15/16 Gene Ontology BP GO:0099517 0.000793904690760903 0.000820897450246773 1720 3336.45454545455 3896 7.21992116918755e-05 1720 0.720236575321983 -0.720236575321983 -1 2.58485763655368 1720 4579 3896 4408 4476 1981 1880 2153 4644 4611 2353 4314 M12940 GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 984/1413 Gene Ontology BP GO:0010562 3.50327381874112e-10 7.95157711151339e-09 4420 2857.45454545455 3896 3.5032738192934e-11 119 2.08688038373131 2.23669772477419 1 20.3392256675497 4606 1349 4396 708 566 4418 3896 4417 2708 119 4249 4315 M10760 GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 1554/2178 Gene Ontology BP GO:0010647 4.75612896150729e-14 1.97591679088334e-12 4215 2735.18181818182 3897 4.75612896150738e-15 69 2.05963565213933 2.21004820787079 1 29.0513213757659 4215 1305 4260 846 726 3946 4073 3897 2454 69 4296 4316 M12495 GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 1776/2298 Gene Ontology BP GO:0044093 6.25441845481127e-08 4.02645553947883e-07 4640 2968.63636363636 3898 6.25441863084115e-09 297 1.89892695953533 2.00311794090331 1 14.583702653479 4636 1297 4371 1472 546 3898 4477 4573 2880 297 4208 4317 M12154 GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. 19/32 Gene Ontology BP GO:0048026 0.0156724775083756 0.0158496061392027 3900 3921.72727272727 3899 0.00143502293674608 2929 0.744769483963483 0.85054120598557 1 1.51832558210351 3899 4281 3848 4267 4580 3493 3172 2929 4641 4410 3619 4318 M12278 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C.html The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. 13/17 Gene Ontology BP GO:0006122 0.00747639154388729 0.00759389868013699 4565 3811.81818181818 3899 0.000681992777695742 2297 0.673879512308261 0.633741655721928 1 1.62443814858036 2297 4562 3899 4537 4562 2863 3105 3332 4413 4616 3744 4319 M13747 GO_MRNA_CLEAVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE.html Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. 21/22 Gene Ontology BP GO:0006379 1.94069063763639e-06 2.62653680538747e-06 3685 3532.36363636364 3901 1.76426577234912e-07 1355 1.24645904034432 -0.862762982179331 -1 8.30962208307215 3681 4536 3901 4560 3407 2499 1355 2514 4156 4256 3991 4320 M11283 GO_RESPONSE_TO_FUNGICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. 13/20 Gene Ontology BP GO:0060992 0.24714328309246 0.247889134776723 3655 3865.27272727273 3902 0.0254771425597989 3069 1.5205649826686 1.6725054812279 1 1.01098283458474 3655 4582 3410 4035 4645 4216 3902 3521 4271 3212 3069 4321 M11974 GO_PSEUDOURIDINE_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHESIS.html The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. 17/17 Gene Ontology BP GO:0001522 7.02366423194115e-07 1.13321533546309e-06 3285 3890.18181818182 3903 6.38515134027217e-08 2839 0.723870639614145 0.771537139520613 1 5.10217788817026 3285 4278 3903 4369 2839 3429 3804 4125 4500 4381 3879 4322 M16096 GO_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING.html The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 384/464 Gene Ontology BP GO:0008380 9.45698651028212e-06 1.1193934935727e-05 1375 3423 3904 8.59729742055898e-07 1371 1.00110129517458 1.01344111532647 1 5.89138354600725 1371 4628 4217 4640 3904 2210 1395 3248 4260 4646 3134 4323 M10043 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY.html A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. 26/46 Gene Ontology BP GO:0045005 0.000192164083527877 0.000202982855994373 940 2823.54545454545 3905 1.7470988236059e-05 537 1.00748766048464 1.08030344503646 1 4.3962290486453 936 4231 3905 4032 4385 950 537 1710 4355 4020 1998 4324 M11256 GO_SULFATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATE_TRANSPORT.html The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/14 Gene Ontology BP GO:0008272 4.91130229692818e-05 5.39223444728806e-05 3485 3719.36363636364 3906 4.91141084431068e-06 2525 1.84731048911682 -1.73455647400617 -1 9.43283587076508 3485 3867 4289 3906 4237 3141 3209 4025 4055 2525 4174 4325 M13819 GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that activates or increases the frequency, rate or extent of chromatin modification. 97/111 Gene Ontology BP GO:1903310 2.30653493424451e-06 3.05328792291314e-06 4330 3788.72727272727 3907 2.09685213861534e-07 2632 1.77025325663197 1.91015410420109 1 11.704821214638 4329 3907 3460 2632 3480 4319 4437 3686 3161 4068 4197 4326 M14428 GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 27/35 Gene Ontology BP GO:0051569 2.89929797894834e-05 3.23666830519353e-05 4545 3811.63636363636 3907 2.63576017129132e-06 2447 1.12356551974908 1.28474463060979 1 5.99808758744481 4542 4223 3863 3622 4146 4511 4400 2447 2550 3907 3717 4327 M13838 GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. 45/140 Gene Ontology BP GO:0050829 1.80165631455919e-06 2.46127622772869e-06 4020 3492.18181818182 3908 1.63787071818158e-07 1776 2.40599262875079 2.16756647770438 1 16.2176499082515 4019 4185 1776 4164 3375 4638 3908 2304 4119 2848 3078 4328 M14955 GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM.html A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). 18/21 Gene Ontology BP GO:0034975 0.0212555013484796 0.0214677334001466 2350 3617.18181818182 3908 0.00195124406904815 2350 1.07451167579893 1.29018917085249 1 2.06490533490083 2350 4568 3908 4074 4606 2994 2802 2378 4633 4292 3184 4329 M11299 GO_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT.html The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. 168/210 Gene Ontology BP GO:0017038 9.06843588209025e-07 1.38709507427238e-06 4325 3828.36363636364 3909 8.24403601828771e-08 3004 1.37429434701714 1.10787787563255 1 9.63325957666637 4324 4653 4086 4080 3004 3416 3553 3327 3321 4439 3909 4330 M13548 GO_BLASTOCYST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_DEVELOPMENT.html The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. 54/76 Gene Ontology BP GO:0001824 2.02038947611931e-05 2.28731684486207e-05 3100 3682.72727272727 3909 1.83673457343953e-06 2345 1.27349463568001 0.992847951116442 1 7.04442693109744 3098 4174 3861 4018 4086 2928 2345 3909 3330 4277 4484 4331 M14820 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. 36/39 Gene Ontology BP GO:0006360 9.71708672472661e-06 1.14871962729047e-05 1960 3169 3909 8.83375422180034e-07 1381 0.850409936428396 1.00162780534916 1 4.97753063524628 1958 4464 4061 4066 3909 1812 1381 1997 4286 4490 2435 4332 M15796 GO_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. 27/31 Gene Ontology BP GO:0032528 0.00786656943189954 0.00798846520441479 3610 3595.36363636364 3909 0.00071771269561558 584 1.36098755546537 -1.10700028682715 -1 3.34953452982959 3610 4227 3771 3315 4563 2992 584 4575 3958 3909 4045 4333 M13525 GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. 20/23 Gene Ontology BP GO:0006488 6.90847550947695e-05 7.4704012422952e-05 2140 3441.54545454545 3910 6.28062950916167e-06 1640 1.00055811637725 -1.08492893662753 -1 4.89059451343794 2136 4526 3910 4547 4271 2791 2464 1640 4436 4082 3054 4334 M16610 GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. 20/23 Gene Ontology BP GO:0006490 6.90847550947695e-05 7.4704012422952e-05 2140 3414.81818181818 3911 6.28062950916167e-06 1334 1.00055811637725 -1.08492893662753 -1 4.89059451343794 2137 4527 3911 4548 4272 2792 2465 1334 4437 4085 3055 4335 M10088 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR.html Any process that modulates the frequency, rate or extent of double-strand break repair. 43/48 Gene Ontology BP GO:2000779 9.82285923108588e-06 1.16033927398433e-05 3255 3948.09090909091 3912 8.92991189981635e-07 3255 1.29484420451816 1.4773499282691 1 7.62580901774608 3255 4442 3778 4383 3912 3862 4120 4232 4291 3555 3599 4336 M13067 GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 29/33 Gene Ontology BP GO:0010869 3.43239160033486e-05 3.8134952522345e-05 4610 3429 3912 3.12040468447565e-06 1874 1.92193490456247 2.01721113149218 1 10.1677392597785 4609 3258 2644 2340 4164 4651 3964 3912 2358 1874 3945 4337 M16540 GO_THYROID_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. 14/35 Gene Ontology BP GO:0030878 2.23331315591184e-07 5.20360846993379e-07 3915 3532.27272727273 3915 2.0302848932954e-08 1929 1.30689911165192 -0.783409558644291 -1 9.828801743427 3915 4291 3374 4044 1929 4106 2185 2942 4236 3978 3855 4338 M13091 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. 102/138 Gene Ontology BP GO:0002474 9.98337343482705e-06 1.17780518743028e-05 2040 3686.27272727273 3917 9.07583521694126e-07 2039 1.13337267279256 -1.1365128189477 -1 6.65311144475493 2039 3664 4073 3836 3917 4321 4621 3328 3967 4224 2559 4339 M13231 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. 31/36 Gene Ontology BP GO:2000142 9.24912959965351e-05 9.93907621875006e-05 3355 3719.90909090909 3917 8.40865315437008e-06 2857 1.23212515052988 0.995728764635415 1 5.86151249982987 3352 4478 3917 4268 4305 2947 2857 2902 4381 4190 3322 4340 M11076 GO_MACROMOLECULE_DEACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_DEACYLATION.html The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. 66/70 Gene Ontology BP GO:0098732 3.48405394163876e-06 4.45365466770471e-06 3450 3457.90909090909 3918 3.16732678110085e-07 1421 1.08569620192353 1.09643648046409 1 6.92348127325369 3446 3918 4053 4050 3614 1665 1421 4374 3960 4107 3429 4341 M11873 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE.html A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 18/19 Gene Ontology BP GO:0033539 0.000576353776442484 0.000597676425626673 3325 3877 3924 5.24095294931974e-05 3321 0.788992491732057 -0.684979496928794 -1 2.97295570240406 3321 4265 3924 4218 4463 3468 3607 3463 4251 4152 3515 4342 M10392 GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 15/18 Gene Ontology BP GO:0009151 0.00167502701037397 0.00171974860531114 2960 3895.72727272727 3926 0.0001523912451505 2956 1.42165789495381 1.79394471046531 1 4.65024351955275 2956 4555 3491 4497 4515 3771 3504 4351 4161 3126 3926 4343 M11194 GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. 59/79 Gene Ontology BP GO:0002792 1.42861597810796e-07 4.2854237685504e-07 4525 3617.27272727273 3926 1.29874188261648e-08 1449 1.84511435046627 -1.72391465169721 -1 14.1070977529784 4525 3926 2457 3979 1449 3520 4639 4464 3755 2893 4183 4344 M14710 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 1135/1522 Gene Ontology BP GO:0031401 9.15438773842102e-08 4.02645553947883e-07 4515 3002.54545454545 3926 9.15438811553371e-09 536 1.93268619708181 2.0630478248705 1 14.8448029851688 4512 1334 4514 1760 1017 4303 3926 4192 2733 536 4201 4345 M15030 GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. 37/44 Gene Ontology BP GO:0031062 9.58893270002867e-05 0.000102828540800261 2325 3457 3927 8.71759151755254e-06 1753 1.31926344209836 -1.39936375553517 -1 6.25976947083845 2322 4457 3927 4069 4312 2764 1753 3445 4382 4055 2541 4346 M11360 GO_PROTEIN_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEALKYLATION.html The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 28/32 Gene Ontology BP GO:0008214 1.42752104184363e-06 2.00309270437226e-06 3045 3876.27272727273 3929 1.29774724374966e-07 3044 0.727453871258062 0.83622413500771 1 4.91029608695383 3044 4224 4030 4558 3284 3918 3929 3052 4494 4315 3791 4347 M13248 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 35/47 Gene Ontology BP GO:0071157 0.00106250421161117 0.00109473695673755 1335 3404.09090909091 3930 9.66379729189352e-05 1335 1.0483101629606 -1.07694722434706 -1 3.65067491166868 1335 4207 3930 4398 4495 2423 2144 2601 4471 4199 3242 4348 M13741 GO_PROTEIN_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMETHYLATION.html The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 28/32 Gene Ontology BP GO:0006482 1.42752104184363e-06 2.00309270437226e-06 3045 3888.18181818182 3930 1.29774724374966e-07 3045 0.727453871258062 0.83622413500771 1 4.91029608695383 3045 4225 4031 4559 3285 3919 3930 3173 4495 4316 3792 4349 M14049 GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. 1524/2035 Gene Ontology BP GO:0051247 8.84273205814145e-08 4.02645553947883e-07 4495 3058.54545454545 3930 8.84273241001407e-09 810 1.9442289286213 2.09624479081261 1 14.93407665521 4492 1314 4471 2199 974 4054 4161 3930 2701 810 4538 4350 M11975 GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. 386/495 Gene Ontology BP GO:0043623 1.80486970669942e-07 4.72066258868601e-07 4195 3556.72727272727 3931 1.64079077706373e-08 1697 1.6479367857235 1.69123490646504 1 12.5048198921767 4192 4341 3872 4228 1697 3069 2833 3931 2311 4362 4288 4351 M15419 GO_HYDROGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_TRANSPORT.html The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 113/157 Gene Ontology BP GO:0006818 2.56788479327947e-07 5.67073823596828e-07 2690 3567.81818181818 3931 2.33444099364388e-08 2047 1.40013433620644 -1.44927394003711 -1 10.4741213513266 2689 4133 3931 4192 2047 4187 4543 2284 3333 4324 3583 4352 M12178 GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 27/29 Gene Ontology BP GO:0034243 3.97441576251538e-07 7.54393074794667e-07 2925 3549.18181818182 3933 3.61310589137697e-08 1983 0.718449829313877 -0.685079401990371 -1 5.21674438582372 2921 3745 4029 4046 2401 2780 1983 4370 4402 4431 3933 4353 M15787 GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. 60/77 Gene Ontology BP GO:0000245 3.83531691240425e-05 4.23889063976651e-05 1830 3411.81818181818 3933 3.48671252373461e-06 1326 0.737398052519065 0.716080068466251 1 3.79669035725382 1827 3933 4138 4077 4177 2424 1326 3190 4470 4528 3440 4354 M12283 GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that activates or increases the activity of an enzyme. 1483/1913 Gene Ontology BP GO:0043085 5.92734779127431e-08 4.02645553947883e-07 4360 2937 3934 5.92734794937484e-09 269 1.92690894932235 2.0166414822292 1 14.8001206577266 4649 1315 4359 1467 487 3934 4358 4596 2723 269 4150 4355 M14354 GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed. 104/137 Gene Ontology BP GO:0006733 1.37533680029307e-06 1.9398127104467e-06 2835 3645.36363636364 3934 1.25030696371807e-07 2490 1.49137379991983 -1.76029415683516 -1 10.2000014063144 2833 4142 3934 4351 3269 3984 4384 2490 3699 4331 2682 4356 M11741 GO_HISTONE_H2A_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_MONOUBIQUITINATION.html The modification of histone H2A by addition of a single ubiquitin group. 15/15 Gene Ontology BP GO:0035518 0.000249846910129511 0.000262542383205198 2130 3006.09090909091 3936 2.27159353590974e-05 380 0.634171793034172 0.684646021234535 1 2.64339335323191 2129 4285 3936 4237 4409 1339 380 1886 4370 4349 1747 4357 M13837 GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 111/138 Gene Ontology BP GO:0033209 3.52453799469221e-07 6.95966502114418e-07 2715 3589.36363636364 3937 3.2041259630413e-08 2300 1.68533133525764 -1.72640806671534 -1 12.4472956230853 2711 4136 3401 2820 2300 4309 4471 4503 3937 4263 2632 4358 M10056 GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 541/699 Gene Ontology BP GO:0033674 6.4723638584617e-08 4.02645553947883e-07 4635 2810.09090909091 3939 6.47236404697342e-09 234 2.04688099446114 2.17970277310283 1 15.72800715801 4631 1443 4221 234 584 4419 3939 4349 2555 570 3966 4359 M11730 GO_RRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_TRANSCRIPTION.html The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. 21/27 Gene Ontology BP GO:0009303 0.000434710975938195 0.000452002272858195 4160 3947.45454545455 3942 3.95269906194109e-05 3202 1.5207345056993 -1.88342969435919 -1 6.04881481907401 4157 3549 3202 3987 4452 4530 3887 4602 3702 3942 3412 4360 M14220 GO_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_METHYLATION.html The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. 33/38 Gene Ontology BP GO:0051568 0.000262656751146139 0.000275691825644706 940 3201.18181818182 3942 2.38807377117248e-05 937 1.00360981998851 -1.1625913151912 -1 4.21752415301492 937 4467 3942 4070 4412 1786 1068 3128 4492 4387 2524 4361 M15886 GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. 21/26 Gene Ontology BP GO:0042762 0.000175063070799966 0.000185339810792319 4215 3872.63636363636 3943 1.59160911674925e-05 3023 0.956965153331087 1.04668746269995 1 4.21631276125254 3943 4026 3879 3617 4375 3023 4211 3662 4212 4261 3390 4362 M12626 GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that reduces the force with which blood travels through the systemic arterial circulatory system. 9/15 Gene Ontology BP GO:0003085 0.420442327744499 0.421347867972249 4025 3970.90909090909 3944 0.0530879004828229 3025 1.44382286537092 -1.66868072508287 -1 0.552477744424126 4021 3863 4378 3572 4631 3922 4354 3944 4564 3025 3406 4363 M13933 GO_NADH_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_METABOLIC_PROCESS.html The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 35/54 Gene Ontology BP GO:0006734 5.73525144033605e-06 7.0486331093195e-06 4260 3519.90909090909 3944 5.21387853800348e-07 1533 1.43413167273537 0.78662604349804 1 8.83266953955079 4260 4204 3645 3944 3760 4516 4269 1533 2009 4280 2299 4364 M16332 GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. 51/56 Gene Ontology BP GO:1904031 1.08668593562308e-05 1.2742816679572e-05 4020 3858.18181818182 3944 9.87901184841181e-07 3240 1.74330884540728 1.65716628132322 1 10.2168709154364 4017 4429 3240 3632 3944 3858 3324 4150 3470 4231 4145 4365 M11750 GO_RNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLATION.html Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. 54/57 Gene Ontology BP GO:0001510 1.09876391959968e-05 1.28714715959147e-05 3425 3795.54545454545 3950 9.98881279349268e-07 2473 0.8697057183721 0.817852164012563 1 5.0408320090234 3425 4431 4121 4425 3950 2815 2473 3712 4538 4416 3445 4366 M12204 GO_CITRULLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CITRULLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. 9/13 Gene Ontology BP GO:0000052 1.83254038722145e-06 2.49467829775934e-06 4085 3198.90909090909 3950 1.83254189841513e-07 914 1.99262162183168 -2.10411857076096 -1 13.3995159949853 4083 1241 4356 1929 3423 4238 4314 4285 914 2455 3950 4367 M12715 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX.html The joining of the small ribosomal subunit, ternary complex, and mRNA. 22/23 Gene Ontology BP GO:0001731 0.000107339269113567 0.000114789615992973 2850 3769.27272727273 3950 9.75859151056257e-06 2592 1.19120459414226 -0.484510087504403 -1 5.57330281434524 2848 4537 4051 3844 4322 2592 2671 3950 4331 4445 3871 4368 M11110 GO_NCRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of a non-coding RNA molecule. 20/22 Gene Ontology BP GO:0043628 3.78853114726206e-05 4.19016767963165e-05 1270 3174.36363636364 3952 3.44417853599979e-06 802 0.671033782919408 0.690745956118936 1 3.44980486759639 1267 4269 3952 4395 4175 1760 802 2302 4525 4601 2870 4369 M11219 GO_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. 1539/2124 Gene Ontology BP GO:0044281 9.92288951155709e-08 4.02645553947883e-07 3955 3253.90909090909 3954 9.92288995464391e-09 1134 1.83011318635789 -1.8345838628784 -1 14.0514839095955 3954 1308 4286 4093 1134 4460 4642 3856 2244 1649 4167 4370 M11655 GO_UV_PROTECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_UV_PROTECTION.html Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. 12/13 Gene Ontology BP GO:0009650 0.00395609519685177 0.00403766416998273 3845 3849.54545454545 3955 0.000360293373423205 1548 0.931843812923316 -0.736308412161463 -1 2.59486029282084 3843 4309 3583 4227 4542 3518 1548 3893 4652 4275 3955 4371 M10901 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. 24/29 Gene Ontology BP GO:2000144 0.000870688838083341 0.000899093467288457 4575 3630.36363636364 3956 7.91848745101568e-05 2405 1.02430299082996 1.05576635310635 1 3.67063621229656 2713 4501 3956 4572 4484 2629 2405 2692 4575 4221 3186 4372 M11474 GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 17/18 Gene Ontology BP GO:0051571 0.00020792653727808 0.000219234574655542 3590 3902.81818181818 3957 1.89041992222339e-05 2896 0.975256073815321 -1.05246490397439 -1 4.21283790485538 3587 4541 3904 4053 4394 3367 2896 3920 4195 4117 3957 4373 M13028 GO_REGULATION_OF_HEXOKINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEXOKINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hexokinase activity. 12/14 Gene Ontology BP GO:1903299 4.7701841615176e-05 5.23977027940071e-05 4510 3697.72727272727 3959 4.33662508628745e-06 2361 1.67279442488236 -1.94833969784922 -1 8.5571865766003 4506 4302 3197 4342 4208 3260 2361 3026 4017 3497 3959 4374 M13855 GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION.html The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. 28/34 Gene Ontology BP GO:0043687 2.42394349192647e-07 5.50444561636596e-07 4625 3919 3959 2.2035852354498e-08 1986 1.55902391876091 1.73430338182951 1 11.6987976912114 4623 4474 3463 4512 1986 3736 3629 4343 3731 3959 4653 4375 M15475 GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the C-terminal amino acid residue in a protein. 11/16 Gene Ontology BP GO:0018410 8.76576451055846e-06 1.04314839559152e-05 4590 3935.09090909091 3960 7.96890857945649e-07 2729 0.901094172229003 -1.19863319872177 -1 5.32595346155571 3960 4587 3797 4532 3884 4045 3532 2729 4588 4246 3386 4376 M11179 GO_BONE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 26/29 Gene Ontology BP GO:0098751 3.93303139718707e-07 7.50765215604951e-07 4580 3666.81818181818 3962 3.57548372755601e-08 2388 1.79395758628544 2.00295015625269 1 13.1847945704025 4577 3988 3021 3282 2388 4365 3962 4416 3157 3116 4063 4377 M14333 GO_HISTONE_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_UBIQUITINATION.html The modification of histones by addition of ubiquitin groups. 37/40 Gene Ontology BP GO:0016574 1.50529686866937e-05 1.73412882642203e-05 3055 3692.45454545455 3962 1.36846106218029e-06 2623 0.696941448142501 0.772109980823761 1 3.90992118755069 3055 3962 4078 4061 4013 3307 3357 2623 4367 4465 3329 4378 M12124 GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. 35/40 Gene Ontology BP GO:0060674 0.000289116699388829 0.000302850068045074 4090 3945 3963 2.62867910125376e-05 3400 1.56903161393171 -2.05191849369073 -1 6.57420356019092 4088 3963 3400 4010 4420 4522 4277 3554 3704 3641 3816 4379 M12405 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY.html Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. 22/23 Gene Ontology BP GO:0035794 3.01430636872339e-06 3.89599098157499e-06 3575 3898 3965 2.74028227159165e-07 3302 1.41682663676146 -1.50043650290917 -1 9.16605280586172 3882 4499 3543 3986 3575 3302 3571 4106 3965 4005 4444 4380 M12274 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that stops, prevents or reduces the rate of gene expression. 75/125 Gene Ontology BP GO:0045814 1.25330891315906e-05 1.45937096419647e-05 2340 3094.54545454545 3969 1.13937823012708e-06 592 1.11659846385526 1.21146649390472 1 6.4274070682976 2338 4157 3984 4409 3969 1849 2978 1283 4209 4272 592 4381 M12136 GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 16/22 Gene Ontology BP GO:0002082 0.00014148287174961 0.000150232725296882 2665 3540 3971 1.28629064898588e-05 1219 1.34771118854205 -1.63085646540202 -1 6.12860374483174 2663 4543 3641 3971 4355 4327 4595 1219 4211 3582 1833 4382 M10980 GO_CELLULAR_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 14/24 Gene Ontology BP GO:0071276 2.42931254402292e-05 2.73231599403883e-05 3375 3720 3972 2.20849033609799e-06 2736 2.41895678663052 -2.86123788291117 -1 13.2473792934631 3374 4297 2840 4519 4114 4215 3502 2736 4188 3972 3163 4383 M12160 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). 663/904 Gene Ontology BP GO:0006366 4.41428570771496e-07 8.15389892735121e-07 3710 3986.09090909091 3972 4.41428658458152e-08 2562 1.54319405127677 -1.50959822181566 -1 11.2604728831079 3706 4609 4347 4429 2562 4498 3972 3708 3567 4514 3935 4384 M14956 GO_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid oxidation. 34/43 Gene Ontology BP GO:0046320 6.28076064257482e-05 6.81856725849292e-05 4040 3943.54545454545 3974 5.70994541693164e-06 3441 1.42988476830036 -1.28693365370684 -1 7.10183183274768 4039 3974 3441 3812 4255 3863 3713 4408 4100 3545 4229 4385 M13861 GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. 4/16 Gene Ontology BP GO:0002837 1.16240233845399e-05 1.35691371822038e-05 4135 3802.18181818182 3976 1.16240841880514e-06 3051 0.896291112289102 0.810958585640092 1 5.17321972411975 4135 3617 4455 3051 3976 3209 3199 4456 4301 3109 4316 4386 M16832 GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 18/26 Gene Ontology BP GO:0043518 0.0532148955028097 0.0535950018992583 4545 3925.63636363636 3976 0.00495885805925151 2845 1.36702395765264 -0.639508232633181 -1 1.99814941813829 3944 4542 3361 3823 4605 3976 3102 2845 4143 4296 4545 4387 M10069 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. 100/140 Gene Ontology BP GO:1903214 1.27891450823903e-07 4.17034908558357e-07 3770 3632.36363636364 3977 1.16264962053228e-08 1315 1.13973044721709 1.12014849465979 1 8.69091344423159 3766 4143 4077 4081 1315 3250 3389 3317 4252 4389 3977 4388 M16192 GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of a response to tumor cell. 4/16 Gene Ontology BP GO:0002834 1.16240233845399e-05 1.35691371822038e-05 4140 3815.63636363636 3977 1.16240841880514e-06 3052 0.896291112289102 0.810958585640092 1 5.17321972411975 4136 3618 4602 3052 3977 3210 3200 4447 4302 3111 4317 4389 M12750 GO_ATP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. 36/46 Gene Ontology BP GO:0006754 0.00790936965616829 0.00803017608774843 3870 4014.63636363636 3978 0.000721631738189779 3203 0.978552396352523 0.598410899670872 1 2.37671347830512 3867 4210 3978 4386 4564 4557 3731 3203 3400 4415 3850 4390 M13570 GO_TRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. 23/23 Gene Ontology BP GO:0030488 0.000108181125790773 0.000115583645994137 3745 3978.45454545455 3980 9.83513143394277e-06 3574 0.855584633769223 0.915685887715164 1 3.97092780609746 3742 4018 3980 4052 4326 3790 3612 3574 4480 4300 3889 4391 M16277 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. 32/34 Gene Ontology BP GO:0000291 9.72382683978085e-05 0.000104223984801172 1585 3444 3980 8.84023331988196e-06 1584 0.74520377329209 0.817048886248499 1 3.48583873128986 1584 3980 4048 4258 4313 2330 2045 2997 4376 4474 3479 4392 M14619 GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. 30/32 Gene Ontology BP GO:0000289 7.53277139491702e-06 9.0474923336471e-06 3015 3903.27272727273 3981 6.84799744286542e-07 3011 0.786624788591926 -0.757684639134092 -1 4.69510836664431 3011 3981 4032 4552 3849 3623 3088 4316 4378 4406 3700 4393 M11394 GO_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 74/100 Gene Ontology BP GO:0005976 2.91046904560851e-08 3.72894192114222e-07 3925 3623.45454545455 3983 2.64588098555662e-09 57 1.38756780403397 1.30166373071169 1 10.6846981747226 3922 4156 3706 3983 57 4025 4401 3977 3266 4313 4052 4394 M12055 GO_NUCLEAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSPORT.html The directed movement of substances into, out of, or within the nucleus. 384/481 Gene Ontology BP GO:0051169 6.72004659776271e-07 1.09702807206058e-06 3510 3804.90909090909 3983 6.10913513676963e-08 2693 1.29866122762343 1.07507985203334 1 9.25746094118862 3509 4624 4197 4089 2804 3015 2693 3983 3761 4544 4635 4395 M11414 GO_DNA_INTEGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRATION.html The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. 7/7 Gene Ontology BP GO:0015074 0.00503233053713195 0.00512484876105821 3545 3489.81818181818 3985 0.000504376294849664 1422 0.898940272884204 0.898940272884204 1 2.38702193827984 3544 4329 4299 3985 4553 2966 1422 2573 4637 4607 1473 4396 M15254 GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN.html The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. 49/58 Gene Ontology BP GO:0051220 6.31869607411259e-05 6.8549528638018e-05 3985 4029.18181818182 3985 5.74443414805925e-06 3698 1.23233948832339 1.28241824292595 1 6.10301158978554 3985 3943 3889 3832 4258 4242 4306 3778 4210 4180 3698 4397 M14303 GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-RNA complex into its constituent components. 17/17 Gene Ontology BP GO:0032988 0.000669085998734631 0.000692912787026984 1875 3311.63636363636 3987 6.08445067766573e-05 1452 0.650591622314409 -0.677985620585223 -1 2.3828714220073 1873 4548 3987 4562 4470 2385 2240 1699 4582 4630 1452 4398 M12598 GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 32/35 Gene Ontology BP GO:0033146 5.92060422873036e-06 7.25153237069817e-06 4630 3994.36363636364 3989 5.38238196565838e-07 2888 1.23717725805419 1.43783027751519 1 7.58706701404506 4626 3729 3613 4014 3769 4571 4321 2888 3985 3989 4433 4399 M10915 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. 324/441 Gene Ontology BP GO:0090316 9.55173307944523e-08 4.02645553947883e-07 4205 3582.18181818182 3990 8.68339408559322e-09 949 1.6975410023541 1.81296808519238 1 13.0261455509145 4204 3630 3533 3833 949 3990 4603 4070 2334 4144 4114 4400 M12787 GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. 19/20 Gene Ontology BP GO:0000466 0.00173636547457088 0.00178233146992682 835 3085.27272727273 3990 0.000157976129948149 401 0.714628007756948 0.714628007756948 1 2.27292822801171 833 4279 3990 4254 4516 1512 401 2354 4507 4411 2881 4401 M10239 GO_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of mRNA metabolic process. 146/183 Gene Ontology BP GO:1903311 4.4693778368418e-06 5.60086589680175e-06 3450 3994.72727272727 3993 4.06307901506075e-07 3450 1.18458739188046 1.32499454132836 1 7.42088532874938 3450 4364 4131 3850 3687 3829 3993 4078 4198 4539 3823 4402 M11252 GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. 26/35 Gene Ontology BP GO:0010833 6.30247009783918e-05 6.840539623337e-05 330 2716.90909090909 3993 5.72968241424425e-06 105 0.875641491228868 0.886078895113706 1 4.30767522604339 329 4238 3993 4056 4256 619 105 1634 4311 4418 1927 4403 M13243 GO_TOXIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. 9/16 Gene Ontology BP GO:0009404 0.145292365446849 0.145919571859311 3460 3912.90909090909 3993 0.015576985616786 3086 1.82994014123531 1.08447434636336 1 1.74696319269925 3458 4107 4416 4024 4647 3993 3086 3137 4573 3873 3728 4404 M16615 GO_RESPONSE_TO_LEAD_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEAD_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. 21/30 Gene Ontology BP GO:0010288 1.74896189551744e-07 4.65466347597117e-07 4000 3764.36363636364 3997 1.58996548596081e-08 1667 1.80194848682295 1.42709241169091 1 13.6964341226711 3997 4236 2835 3946 1667 4160 4434 4556 3918 3172 4487 4405 M15870 GO_CELLULAR_MACROMOLECULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULE_LOCALIZATION.html Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 1320/1626 Gene Ontology BP GO:0070727 7.76978245133451e-08 4.02645553947883e-07 4000 3617.45454545455 3998 7.76978272299735e-09 821 1.60434804447525 -1.39754671992025 -1 12.3053735791004 3998 3871 4578 3818 821 4068 3457 4131 2352 4485 4213 4406 M16464 GO_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLATION.html The covalent attachment of a mannose residue to a substrate molecule. 29/31 Gene Ontology BP GO:0097502 1.95704821638226e-07 4.93246485651519e-07 3565 3722.72727272727 4001 1.77913490043173e-08 1767 1.08995423085076 1.2828249228627 1 8.21076797475246 3564 4476 3907 4370 1767 4359 4188 2671 4001 4239 3408 4407 M10586 GO_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAPPING.html A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. 16/30 Gene Ontology BP GO:0016233 0.00092680664721186 0.000956193199440528 2590 3579.27272727273 4002 8.42906653461976e-05 915 0.714931500819155 -0.894704114323345 -1 2.50777190702739 2589 4575 3946 4413 4486 2093 915 4002 4604 4595 3154 4408 M15151 GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 18/23 Gene Ontology BP GO:0042776 0.0336092314115197 0.0338933146419161 4640 3466.63636363636 4002 0.00310308492313342 1051 0.56968069018313 0.56968069018313 1 0.909749987650675 1175 4563 4002 4415 4598 2194 1051 3292 4638 4639 3566 4409 M13938 GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. 18/18 Gene Ontology BP GO:0007004 6.20427325259248e-05 6.74182238307165e-05 915 2961.36363636364 4005 5.64040747973876e-06 432 0.670133874602092 0.658668336029417 1 3.27764353105796 914 4289 4005 4060 4251 1141 432 1994 4565 4627 2297 4410 M12417 GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 22/29 Gene Ontology BP GO:0045978 0.000184611432217342 0.000195226589569839 4175 3810.45454545455 4006 1.67842659613007e-05 2728 1.16043149713317 -0.781912273682595 -1 5.10298427147985 4173 4021 3694 4248 4379 3168 3315 3753 4430 4006 2728 4411 M11505 GO_HISTONE_H2A_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_UBIQUITINATION.html The modification of histone H2A by addition of one or more ubiquitin groups. 20/20 Gene Ontology BP GO:0033522 7.48977128228457e-05 8.08582500614156e-05 2475 3282.81818181818 4007 6.80911479938141e-06 1258 0.603062165277988 0.640506712297795 1 2.88170981528825 2474 4017 4007 4399 4281 1928 1258 2107 4364 4423 2853 4412 M13830 GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. 22/29 Gene Ontology BP GO:1903579 0.000184611432217342 0.000195226589569839 4175 3818.09090909091 4007 1.67842659613007e-05 2729 1.16043149713317 -0.781912273682595 -1 5.10298427147985 4174 4022 3695 4249 4380 3169 3316 3827 4431 4007 2729 4413 M14193 GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of cytoplasmic transport. 585/775 Gene Ontology BP GO:1903649 9.4782903825635e-08 4.02645553947883e-07 4355 3306.90909090909 4007 9.47829078683446e-09 1035 1.81434138446452 1.94775097828574 1 13.9295018091397 4355 2332 4479 1035 1064 4007 4317 4523 1996 3651 4617 4414 M15269 GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html A process in which a protein is transported to, or maintained in, a location within the mitochondrion. 80/92 Gene Ontology BP GO:0070585 1.47652467953714e-05 1.70351334834771e-05 1045 3198.45454545455 4007 1.34230417208176e-06 1044 1.01523955959146 1.00767097118174 1 5.75212978659048 1044 4406 4145 4614 4007 1788 1203 2471 4309 4516 2680 4415 M12277 GO_ALDITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 18/26 Gene Ontology BP GO:0019400 0.0018826191724094 0.00193203065929002 3570 3798.90909090909 4013 0.000171293830008115 1520 1.51929781271117 -1.18556551159842 -1 4.88381432576341 3567 4034 3241 4510 4619 4360 4013 1520 3999 3776 4149 4416 M13544 GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. 43/62 Gene Ontology BP GO:0000381 9.54508941852482e-05 0.000102381975713223 1340 3526.45454545455 4013 8.67773052207409e-06 1337 1.09457948259713 1.26964246708605 1 5.17863457992158 1337 4450 4013 4566 4311 2581 2337 3694 4111 4441 2950 4417 M15310 GO_ENDOPLASMIC_RETICULUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. 44/47 Gene Ontology BP GO:0007029 7.20057643306507e-08 4.02645553947883e-07 4015 3410.09090909091 4013 6.54597878976291e-09 601 1.44083864084876 -1.26540210452921 -1 11.0407609093832 4013 4189 3794 4207 601 4568 4275 2129 1862 4060 3813 4418 M16900 GO_QUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving quinone. 32/46 Gene Ontology BP GO:1901661 7.89838008540219e-07 1.24449051926961e-06 4315 3860.54545454545 4013 7.18034811005321e-08 2906 1.31958861031932 -1.42360756659362 -1 9.3208862048054 4312 3727 3618 4013 2906 3791 3517 4218 4183 4112 4069 4419 M10437 GO_MULTI_ORGANISM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_TRANSPORT.html The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. 76/115 Gene Ontology BP GO:0044766 6.18536090176148e-06 7.53810483915562e-06 3115 3798.72727272727 4014 5.62307117467575e-07 2323 0.989995004216182 0.914245580497056 1 6.03048250617088 3114 4397 4111 4592 3789 2848 2323 3853 4343 4402 4014 4420 M13896 GO_MULTI_ORGANISM_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_LOCALIZATION.html A localization which involves another organism. 76/115 Gene Ontology BP GO:1902579 6.18536090176148e-06 7.53810483915562e-06 3115 3811.72727272727 4015 5.62307117467575e-07 2324 0.989995004216182 0.914245580497056 1 6.03048250617088 3115 4398 4112 4593 3790 2849 2324 3986 4344 4403 4015 4421 M16222 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 35/35 Gene Ontology BP GO:0090503 8.56763547656031e-08 4.02645553947883e-07 4455 3463.18181818182 4016 7.78875982746966e-09 827 0.890353280174081 0.765507647889512 1 6.78320295758917 3280 4203 4016 4549 827 2604 1933 4069 3708 4454 4452 4422 M10417 GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 43/54 Gene Ontology BP GO:0000271 1.11038452105813e-07 4.02645553947883e-07 4380 3713 4018 1.00944052463772e-08 1162 1.2553291907459 -1.07171290206686 -1 9.60599571698942 4379 3948 3698 4363 1162 4306 3924 2801 4187 4018 4057 4423 M12563 GO_RNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. 114/121 Gene Ontology BP GO:0009451 1.52729770558176e-05 1.7572987695529e-05 2650 3668.18181818182 4018 1.38846209871463e-06 2219 0.989371271272219 0.98731591027143 1 5.58678883833519 2650 4380 4179 4448 4018 2434 2219 3955 4340 4531 3196 4424 M13990 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. 76/106 Gene Ontology BP GO:0042590 1.53079409551768e-05 1.76088626117275e-05 2040 3730.72727272727 4019 1.39164067920364e-06 2037 0.945628476715009 -1.02737587404981 -1 5.33421674335687 2037 3674 4092 3845 4019 4345 4253 3373 4373 4286 2741 4425 M14352 GO_CYCLOOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLOOXYGENASE_PATHWAY.html The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. 12/22 Gene Ontology BP GO:0019371 0.00321864127486008 0.0032893340329286 3685 3914.09090909091 4019 0.000293032715911331 2508 2.60121867145528 -3.24261589083253 -1 7.70798946067356 3682 4570 2508 3967 4537 4447 3512 4487 4244 3082 4019 4426 M11466 GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING.html Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. 20/21 Gene Ontology BP GO:0000469 0.00306426125933839 0.00313225123895025 4525 3169.45454545455 4022 0.00027895796769733 504 0.691687427208283 0.691687427208283 1 1.99182060671843 1012 4525 4022 4564 4536 1603 504 2221 4522 4422 2933 4427 M12437 GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of granulocyte differentiation. 15/21 Gene Ontology BP GO:0030852 0.000382011988493051 0.000398543000551158 4440 4006.09090909091 4024 3.47343943524819e-05 2576 1.2151908123332 -1.42392956567733 -1 4.89314887491909 3658 4295 3592 4019 4439 4436 4503 2576 4601 4024 3924 4428 M16149 GO_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. 731/971 Gene Ontology BP GO:0032386 8.79567306635466e-08 4.02645553947883e-07 4375 3193.63636363636 4024 8.79567341449205e-09 964 1.81157508669065 1.97729401958284 1 13.90810673867 4374 1400 4597 1444 964 4024 4079 4387 1900 3601 4360 4429 M12677 GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. 49/63 Gene Ontology BP GO:0009201 1.45074587557059e-06 2.03322908404517e-06 4190 3887.36363636364 4026 1.31886075657886e-07 2834 0.945896163974886 0.772592646145316 1 6.4082738977503 4190 3693 4026 4016 3289 4205 2834 4191 3363 4451 4503 4430 M10273 GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON.html A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. 38/38 Gene Ontology BP GO:0044380 3.42175028413008e-07 6.84715782949634e-07 4525 3936.90909090909 4027 3.11068256029914e-08 2269 1.19023856556984 1.30780301803207 1 8.77064850239842 4521 3705 3795 4009 2269 4437 4427 4027 4088 3638 4390 4431 M11029 GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 84/108 Gene Ontology BP GO:0071322 1.09718494880933e-07 4.02645553947883e-07 4565 3799.54545454545 4027 9.97440912298356e-09 1141 1.56767939374471 1.71875423810841 1 12.0217712952758 4563 4388 3490 4563 1141 4621 3413 3888 4027 3243 4458 4432 M11831 GO_MRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. 11/13 Gene Ontology BP GO:0016556 3.50189699834517e-05 3.88700542302006e-05 4245 3580.18181818182 4027 3.18359340161907e-06 1610 1.90232988933195 -0.88689632953596 -1 10.0438942817298 4241 4310 3325 3585 4168 4430 4262 1610 2173 4027 3251 4433 M12743 GO_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYUBIQUITINATION.html Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. 270/313 Gene Ontology BP GO:0000209 3.92075570891104e-07 7.49518336629543e-07 3045 3768.36363636364 4029 3.56432400695753e-08 2385 1.17851857000045 -1.28326174647598 -1 8.62729805173377 3042 4633 4172 4432 2385 4029 4039 3820 3317 4494 3089 4434 M11623 GO_CELL_PROLIFERATION_IN_FOREBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION_IN_FOREBRAIN.html The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. 25/46 Gene Ontology BP GO:0021846 1.31615209130128e-07 4.19743364004444e-07 4520 3433.18181818182 4030 1.19650197276383e-08 1356 1.70907498961442 -1.32411224714669 -1 13.0780205364042 4517 2595 2638 4318 1356 4358 4486 4046 3131 2290 4030 4435 M10434 GO_MRNA_SPLICE_SITE_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_SPLICE_SITE_SELECTION.html Selection of a splice site by components of the assembling spliceosome. 30/42 Gene Ontology BP GO:0006376 1.62578472936121e-05 1.86370444585309e-05 3430 3987.90909090909 4031 1.47799703992892e-06 3426 0.827390933105128 0.791099082387991 1 4.62971290639912 3426 3514 3991 4225 4031 3883 4240 3788 4318 4404 4047 4436 M16240 GO_PEPTIDYL_LYSINE_DIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_DIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. 15/15 Gene Ontology BP GO:0018027 0.000334479062057893 0.000349658745395501 3755 4038.72727272727 4033 3.04118114292978e-05 3148 0.797857449583864 0.968646895161888 1 3.23217193561636 3752 4293 3870 4033 4430 4549 4605 3204 4516 4026 3148 4437 M12427 GO_LEYDIG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEYDIG_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. 8/13 Gene Ontology BP GO:0033327 9.70730360546772e-06 1.14785473128949e-05 4035 3708.81818181818 4034 9.70734601001292e-07 1221 1.07654419310409 0.708213651512533 1 6.32891966363957 4034 2743 4368 3463 3941 4503 4509 3698 1221 4115 4202 4438 M13046 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 32/36 Gene Ontology BP GO:0006294 1.64650443011896e-05 1.88586131096186e-05 1745 3353.81818181818 4034 1.49683341170006e-06 1549 0.812696280218731 0.902540877811613 1 4.5406147880111 1744 4221 4060 4272 4034 1872 1549 2991 4563 4473 3113 4439 M13056 GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. 14/38 Gene Ontology BP GO:0071875 0.142977311859072 0.143625525060505 3955 4050.63636363636 4034 0.0139285320090357 3417 1.41959049351551 -1.96210242088222 -1 1.34394820946299 3955 4082 3417 4034 4617 4434 4134 3772 4403 3717 3992 4440 M15788 GO_SNRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_PROCESSING.html Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. 23/23 Gene Ontology BP GO:0016180 0.00125970523940341 0.00129476661783611 4510 3599.27272727273 4034 0.000114584283356099 1679 0.671532732407707 0.7094362457662 1 2.24237559510455 2192 4509 4034 4574 4506 2264 1679 3174 4543 4642 3475 4441 M12248 GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. 19/22 Gene Ontology BP GO:0030970 0.0489365182543349 0.0493074100124341 3075 4055 4035 0.00455092809567411 3073 0.605619834639483 -0.605619834639483 -1 0.854399084168033 3073 4550 4035 4270 4603 3974 3802 3494 4622 4615 3567 4442 M11336 GO_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION.html The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 37/52 Gene Ontology BP GO:0006306 1.65139325471977e-05 1.89026637495967e-05 3690 4007.54545454545 4036 1.50127786432516e-06 3471 1.15171020267469 1.28818269588105 1 6.4762564328527 3689 4199 3915 4392 4036 3808 4185 3918 4094 4376 3471 4443 M12202 GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. 8/10 Gene Ontology BP GO:0006995 7.6806478861133e-07 1.21392848553279e-06 4355 3996.90909090909 4037 7.68065054077043e-08 2959 0.688239503435676 -0.476520274947795 -1 4.82109380550332 4037 3861 4355 4354 2959 3979 3677 3996 4482 4114 4152 4444 M16784 GO_DNA_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_ALKYLATION.html The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. 37/52 Gene Ontology BP GO:0006305 1.65139325471977e-05 1.89026637495967e-05 3690 4010.90909090909 4037 1.50127786432516e-06 3472 1.15171020267469 1.28818269588105 1 6.4762564328527 3690 4200 3916 4393 4037 3809 4186 3945 4095 4377 3472 4445 M14031 GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. 8/10 Gene Ontology BP GO:0043562 7.6806478861133e-07 1.21392848553279e-06 4040 4005.63636363636 4038 7.68065054077043e-08 2960 0.688239503435676 -0.476520274947795 -1 4.82109380550332 4038 3862 4468 4355 2960 3980 3678 3969 4483 4116 4153 4446 M13029 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 18/19 Gene Ontology BP GO:2001241 0.000183993820018021 0.000194661947372408 4285 3921.18181818182 4041 1.67281099888352e-05 2805 1.39865835496679 1.34801557420482 1 6.17384832125652 4282 4280 3496 4041 4378 3938 2805 3245 4435 3779 4454 4447 M13939 GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. 5/18 Gene Ontology BP GO:0032645 0.000111607074984442 0.000119161936645849 4265 3648.27272727273 4041 1.11612680643313e-05 922 2.15138406166054 -1.82142590989661 -1 10.106454227823 4262 3399 4461 3480 4344 4598 4041 922 3869 2618 4137 4448 M14922 GO_MULTI_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_METABOLIC_PROCESS.html A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism. 160/247 Gene Ontology BP GO:0044033 2.76182314258514e-06 3.59663114538166e-06 1975 3593.81818181818 4044 2.51075146337512e-07 1193 0.792061649253829 -0.603486001117548 -1 5.1120434463128 1975 4368 4208 3853 3544 2563 1193 4591 4558 4635 4044 4449 M13168 GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 229/292 Gene Ontology BP GO:0009141 2.60081639382391e-07 5.68951512950759e-07 1950 3479.45454545455 4045 2.36437881935425e-08 1950 1.38950416737502 1.34124122090133 1 10.3914049638281 1950 4346 4080 4546 2066 3047 2301 4045 3265 4450 4178 4450 M13659 GO_TRNA_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_TRANSPORT.html The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 35/40 Gene Ontology BP GO:0051031 1.88943875948075e-05 2.14532907463737e-05 730 2919.54545454545 4045 1.71768635168395e-06 358 0.840443295618447 0.779152957919064 1 4.64225131347774 727 4462 4045 4266 4074 1142 358 1734 4425 4354 2528 4451 M15284 GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS.html Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. 13/15 Gene Ontology BP GO:0051457 0.000483536790134935 0.000502209081361128 3770 3946.09090909091 4045 4.39675544666724e-05 2775 1.29875981414012 -0.694808430588833 -1 5.07901780651211 3769 4314 3750 4045 4456 3700 2775 3573 4348 4135 4542 4452 M14442 GO_MITOCHONDRIAL_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FUSION.html Merging of two or more mitochondria within a cell to form a single compartment. 18/23 Gene Ontology BP GO:0008053 4.18916364052883e-05 4.61899962544565e-05 4050 3988.90909090909 4048 3.80840310114129e-06 3183 1.16509832752393 -1.38165026215833 -1 6.00598386867563 3183 4273 3813 4048 4191 3987 3901 4170 4049 4399 3864 4453 M16415 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 42/54 Gene Ontology BP GO:0044246 1.70906792178316e-05 1.9529206876368e-05 4105 3853.27272727273 4048 1.55371018073233e-06 2507 1.80484619526726 1.78268873531058 1 10.1764237202326 4105 3946 2507 3799 4043 4124 4048 4533 4515 2520 4246 4454 M12852 GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 86/96 Gene Ontology BP GO:0070301 1.24242176825468e-06 1.78150646770077e-06 3935 3982.09090909091 4049 1.12947497263362e-07 3204 1.5985420100548 -1.67286155624889 -1 11.0118365694637 3935 4386 3552 4067 3204 4487 4101 4562 3689 3771 4049 4455 M15487 GO_RNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an RNA molecule. 109/144 Gene Ontology BP GO:0031123 9.20320343912484e-06 1.09129728853843e-05 2255 3722.45454545455 4049 8.36658358079513e-07 2152 0.710228478179659 0.645269840402521 1 4.15919322362571 2251 4383 4211 4625 3896 2485 2152 4049 4536 4583 3776 4456 M10551 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION.html The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. 115/151 Gene Ontology BP GO:0006353 1.74010469389461e-05 1.98546030914459e-05 1225 3283.45454545455 4050 1.58192587047393e-06 1040 0.777809726924139 0.771209790082209 1 4.32025489707982 1222 4382 4186 4627 4050 1716 1040 2788 4491 4580 3036 4457 M12577 GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. 27/40 Gene Ontology BP GO:0000027 4.38666798180812e-05 4.82875943206842e-05 2395 3703.54545454545 4050 3.98795950161551e-06 2088 0.623405859116079 -0.570822260766971 -1 3.15119447138472 2395 4253 4050 4275 4199 3478 2088 3270 4630 4368 3733 4458 M10151 GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION.html The acetylation of the N-terminal amino acid of proteins. 13/15 Gene Ontology BP GO:0006474 0.68618940391 0.68633690808109 3835 4096.90909090909 4054 0.1 2973 0.570382378192777 0.542675916478401 1 0.00980182868987389 4054 4589 3937 3835 4649 3820 2973 3835 4621 4593 4160 4459 M16965 GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. 28/42 Gene Ontology BP GO:0048025 0.00580597632992166 0.00590754600112081 1310 3375.72727272727 4054 0.000529214147175979 1307 0.729791574208015 0.768799576685017 1 1.86401609022615 1307 4494 4054 4586 4554 2063 1512 2395 4602 4482 3084 4460 M11174 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. 820/988 Gene Ontology BP GO:0070647 2.57662775486645e-07 5.67433145203964e-07 4605 3932.63636363636 4055 2.57662805362197e-08 2139 1.28414805872033 1.3629693317492 1 9.5974953000152 3959 4605 4281 4458 2139 3653 4093 4055 3504 4602 3910 4461 M11930 GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. 25/29 Gene Ontology BP GO:0045947 0.0083783015876882 0.00850255993184584 2780 3750.63636363636 4056 0.000764579999415417 2033 0.86014412240541 -1.0401740733655 -1 2.05084057799227 2777 4521 4056 4277 4652 3297 3726 2033 4493 4469 2956 4462 M16451 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 29/48 Gene Ontology BP GO:0032786 4.77102424420717e-06 5.9516289030284e-06 3375 3957.45454545455 4057 4.33730417355257e-07 2742 0.68007525328485 0.659882227105623 1 4.19480600139755 3372 4226 4047 4057 3704 3516 2742 4468 4529 4452 4419 4463 M13743 GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 461/528 Gene Ontology BP GO:0042176 1.54629525611048e-07 4.40634342739212e-07 4035 3680.45454545455 4058 1.4057230589033e-08 1538 1.4358386932564 -1.29431043994376 -1 10.9340969755772 4033 3406 4108 3120 1538 4641 4319 4137 2705 4420 4058 4464 M14008 GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. 107/154 Gene Ontology BP GO:2000117 6.58930144784542e-07 1.08479953043585e-06 4285 3818.90909090909 4058 5.99027583766574e-08 2777 1.64545089469608 1.53131825753343 1 11.7667202102666 4281 4139 3386 4058 2777 3755 3850 3011 4098 4095 4558 4465 M15649 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING.html The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. 25/29 Gene Ontology BP GO:0000717 0.00683753408622352 0.00694955135500176 3450 4017.63636363636 4058 0.000623534351399883 3077 0.664597627898348 0.725807901227806 1 1.63159664947051 3447 4505 4058 4280 4560 3077 3229 3902 4636 4641 3859 4466 M14240 GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. 91/152 Gene Ontology BP GO:0043255 6.82887772091386e-07 1.11016340950201e-06 4060 3675.63636363636 4060 6.20807258238414e-08 2401 1.92913696766615 2.10035607613872 1 13.789709042053 4060 3182 2401 4139 2817 4596 4375 4217 3741 2625 4279 4467 M13789 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. 26/27 Gene Ontology BP GO:0034198 0.123731643170267 0.124319441950173 3815 3921.27272727273 4061 0.0119357328183978 2524 1.50999302861575 -1.1881514077937 -1 1.55057828302627 3815 4492 3779 4525 4618 3564 2524 3037 4061 4157 4562 4468 M10089 GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS.html A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. 24/26 Gene Ontology BP GO:0006278 0.000486533065236131 0.00050520829112781 1675 3456.36363636364 4063 4.42400632751494e-05 1673 0.670133874602092 0.658668336029417 1 2.56874134896121 1673 4528 4063 4076 4457 1925 2106 2958 4631 4592 3011 4469 M13702 GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. 34/36 Gene Ontology BP GO:0000959 4.44535770047721e-05 4.8922065705583e-05 4065 3764.18181818182 4063 4.04131593334342e-06 2182 0.876107410862138 0.704064277573065 1 4.46427901810601 4063 3722 4008 4241 4200 2605 2182 3124 4407 4341 4513 4470 M16928 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. 1656/2274 Gene Ontology BP GO:0006357 1.83709781461993e-07 4.7749337740829e-07 4065 3931.63636363636 4063 1.83709796649172e-08 1814 1.68574020056533 1.83430408696856 1 12.7839193071074 4558 3621 4651 4385 1814 4298 4018 4063 3473 4061 4306 4471 M10954 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. 61/71 Gene Ontology BP GO:2001021 2.86076703166388e-07 6.03154693443602e-07 4360 3810.63636363636 4064 2.60069763969401e-08 2146 1.62374177809315 1.74347032449498 1 12.1107190400646 4356 4166 3465 4194 2146 4032 4274 4175 3045 4064 4000 4472 M13533 GO_REGULATION_OF_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_DUPLICATION.html Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 36/42 Gene Ontology BP GO:0010824 9.53968840148616e-07 1.43837233091753e-06 4330 3842.72727272727 4065 8.67244776191758e-08 1995 0.991025880956731 -1.00822853106327 -1 6.89909086452897 4330 1995 3855 4506 3050 4267 3578 4065 4131 4013 4480 4473 M10908 GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE.html The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. 15/15 Gene Ontology BP GO:0016254 0.0141575060239862 0.0143325602047982 3520 3978.27272727273 4066 0.00129540383529166 2617 0.684965384422721 -0.832715270257684 -1 1.42433494867042 3516 4287 3882 4017 4576 4453 4066 2617 4426 4348 3573 4474 M11419 GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. 27/39 Gene Ontology BP GO:0043508 0.000357649204561211 0.000373628592012419 4265 3598.09090909091 4066 3.2518850913558e-05 1667 1.75927566992958 2.3077470150995 1 7.18973566697755 4261 3519 2737 3794 4433 4090 4336 2058 1667 4066 4618 4475 M11281 GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. 60/77 Gene Ontology BP GO:1903313 1.16982756433299e-06 1.69043716050975e-06 4640 4095.36363636364 4067 1.06348016943394e-07 3183 1.3004823201794 1.56333052302936 1 8.97524452445198 4637 3931 3753 4565 3183 4607 4067 3923 4166 4363 3854 4476 M13695 GO_HISTONE_H4_K8_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K8_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. 16/16 Gene Ontology BP GO:0043982 1.84346775220838e-05 2.09671362772564e-05 4035 4123.63636363636 4067 1.67589381776473e-06 3767 0.719042939039537 -0.579792337276913 -1 3.96547210874394 3767 4283 3918 4541 4067 3823 4032 4033 4433 4366 4097 4477 M14977 GO_HISTONE_H4_K5_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K5_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. 16/16 Gene Ontology BP GO:0043981 1.84346775220838e-05 2.09671362772564e-05 3770 4123.90909090909 4068 1.67589381776473e-06 3768 0.719042939039537 -0.579792337276913 -1 3.96547210874394 3768 4284 3919 4542 4068 3824 4033 4026 4434 4367 4098 4478 M15831 GO_PEPTIDYL_ASPARAGINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ASPARAGINE_MODIFICATION.html The modification of peptidyl-asparagine. 35/40 Gene Ontology BP GO:0018196 5.20891514396608e-05 5.69346538991641e-05 3820 4041.27272727273 4068 4.73548952631792e-06 3676 1.3805356481957 -1.11872775316914 -1 6.98393381063915 3950 3970 3819 4197 4230 4296 4331 4097 3676 3820 4068 4479 M10378 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 16/17 Gene Ontology BP GO:0090141 9.96471311421436e-05 0.000106661628986518 3730 3848.18181818182 4069 9.059240441866e-06 2566 1.14283677563651 1.2079826971113 1 5.38690586043603 3729 4546 3775 4403 4316 2926 2566 3302 4555 4069 4143 4480 M11260 GO_TELOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. 89/120 Gene Ontology BP GO:0032200 7.20905471957865e-05 7.78818936851625e-05 4075 2610.72727272727 4072 6.55390087256846e-06 198 1.12619730567827 1.19035799147829 1 5.49298797063157 297 4152 4075 4072 4276 316 198 1107 4453 4412 1360 4481 M16816 GO_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_SPLICING.html Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 113/150 Gene Ontology BP GO:0043484 1.88615506138256e-05 2.14212338311278e-05 1960 3600.90909090909 4073 1.71470112036273e-06 1957 1.11673274825727 1.18707349893907 1 6.20308045944762 1957 4376 4129 4292 4073 2990 2502 3187 4321 4502 3281 4482 M13429 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 202/268 Gene Ontology BP GO:0015931 3.02859280669645e-06 3.91119687192855e-06 4075 3567.81818181818 4074 2.75326997815052e-07 1582 1.2046881379715 0.97562173423782 1 7.77575840406003 2467 4349 4167 4075 3578 2346 1582 4564 3525 4519 4074 4483 M15661 GO_MATURATION_OF_5_8S_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA.html Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. 28/29 Gene Ontology BP GO:0000460 0.00024612199718748 0.000258686616876744 790 3173.63636363636 4076 2.23772305512091e-05 595 0.673555686944172 0.678624057659455 1 2.81918382424684 788 4488 4076 4416 4408 1621 595 2497 4535 4481 3005 4484 M14987 GO_PRE_MIRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MIRNA_PROCESSING.html Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. 11/13 Gene Ontology BP GO:0031054 0.00642332858170314 0.00653141343764526 3875 4109.45454545455 4077 0.000585650887248722 2893 0.533694374248453 0.533694374248453 1 1.30734266787298 3873 4592 3909 4570 4558 3473 2893 4077 4650 4636 3973 4485 M11010 GO_NEGATIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RNA_SPLICING.html Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. 34/50 Gene Ontology BP GO:0033119 0.00117826067699972 0.00121212622818477 4590 3400.81818181818 4079 0.000107172017746459 1262 0.726323218164812 0.744428663516492 1 2.4588927619727 1571 4472 4079 4588 4503 2248 1262 2206 4586 4478 3416 4486 M14267 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. 15/21 Gene Ontology BP GO:0071636 1.93941969587596e-05 2.19885961133305e-05 4290 3980.72727272727 4080 1.76312435738797e-06 3116 1.59271240886399 -0.838117864198188 -1 8.86900456044252 4287 4553 3116 3981 4080 4558 3748 3485 4396 3472 4112 4487 M12048 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION.html The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. 26/30 Gene Ontology BP GO:0000715 0.000393211635084513 0.000410043419553617 3215 3811.54545454545 4082 3.57529029452764e-05 2105 0.6103453973594 0.629062682910371 1 2.39728219249051 3215 4506 4082 4282 4441 2841 2105 3529 4639 4613 3674 4488 M13506 GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. 23/28 Gene Ontology BP GO:0051570 1.97778229327789e-05 2.24126181456942e-05 4350 4014 4082 1.79800006691392e-06 2605 1.218826740866 0.971292045395293 1 6.75062916440228 4347 4493 3703 4396 4082 3772 2605 4336 4504 3861 4055 4489 M16267 GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 224/307 Gene Ontology BP GO:0040029 1.73497982807448e-06 2.37997085496184e-06 4085 3737.90909090909 4084 1.5772556330257e-07 2139 1.40638088605728 1.52264505889286 1 9.46178138570207 3216 4642 4084 4443 3360 3557 4238 2139 4085 4475 2878 4490 M14315 GO_NON_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_RECOMBINATIONAL_REPAIR.html A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. 63/88 Gene Ontology BP GO:0000726 2.0089959794065e-05 2.27497159702566e-05 2880 3567.63636363636 4085 1.82637665944577e-06 2133 0.882980178733547 0.950255593780679 1 4.85520628280163 2877 4424 4123 4281 4085 2133 2483 3381 4420 4476 2561 4491 M12311 GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. 28/50 Gene Ontology BP GO:0000060 2.4531178633245e-05 2.75775728872889e-05 4090 3932 4087 2.23013201575448e-06 2944 1.53265083341585 0.821882327070219 1 8.34835386146911 4087 4222 3423 4238 4116 3566 2944 4505 3841 3958 4352 4492 M14886 GO_MACROMOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. 939/1194 Gene Ontology BP GO:0009057 1.45551055693497e-07 4.33300743532847e-07 4635 3911.45454545455 4087 1.45551065226797e-08 1585 1.31046869277872 -1.11714558370097 -1 9.98195052421494 3832 4603 4521 4634 1585 4087 3591 3783 3209 4634 4547 4493 M12744 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION.html Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. 130/173 Gene Ontology BP GO:0071166 2.75697829752693e-05 3.08296563768152e-05 4140 3342.36363636364 4090 2.50637531619262e-06 1176 0.890529334722572 0.799499384829992 1 4.75544011677969 1176 4137 4202 4090 4137 2137 1430 3224 4288 4567 3378 4494 M15215 GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. 11/11 Gene Ontology BP GO:0070525 0.000140622312102189 0.000149353028580572 3720 4071 4090 1.27846637615384e-05 3371 0.759717439280107 0.750343328840423 1 3.41217530978518 3719 4090 3763 4361 4354 3371 4031 4453 4510 4245 3884 4495 M11708 GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/16 Gene Ontology BP GO:0032239 0.000240940804008613 0.000253469943715143 4595 3847.36363636364 4092 2.19061086856404e-05 2036 1.90956822368295 -0.623116182291202 -1 8.20191055259683 4592 3845 3431 3304 4405 4280 4191 4092 2036 4133 4012 4496 M12877 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS.html The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. 111/130 Gene Ontology BP GO:0090501 4.20668282596805e-07 7.88308304036622e-07 3645 3776.45454545455 4093 3.82425784576373e-08 2435 1.25741917282903 1.05115437242023 1 9.1784548765625 3643 4375 4093 4595 2435 2920 2458 4364 3653 4480 4525 4497 M12878 GO_ORGANIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. 835/1183 Gene Ontology BP GO:0006082 1.18585869240767e-07 4.09676049985113e-07 4395 3145.72727272727 4095 1.18585875568941e-08 957 1.91879986842957 -1.91719734915485 -1 14.7199580564787 4095 1377 4392 2636 1346 4520 4393 4463 2117 957 4307 4498 M10803 GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. 126/152 Gene Ontology BP GO:0034250 4.67071146901489e-07 8.45306124672356e-07 4280 3711.27272727273 4097 4.24610223693718e-08 1089 1.80850435206995 1.90889571666427 1 13.1798793103598 4276 4132 3060 4487 2520 4019 4648 3921 1089 4097 4575 4499 M16191 GO_PEPTIDYL_LYSINE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_METHYLATION.html The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. 75/84 Gene Ontology BP GO:0018022 3.29884852079686e-05 3.67213927446597e-05 1970 3435.54545454545 4098 2.99899817026995e-06 1386 1.04953771586257 -1.02144790967637 -1 5.5265263609152 1970 4403 4098 4436 4157 2272 1386 3232 4384 4395 3058 4500 M14640 GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosyl compound. 348/462 Gene Ontology BP GO:1901657 1.38430032562652e-07 4.24877929758589e-07 4105 3509.45454545455 4101 1.25845492066409e-08 1414 1.46053453522187 1.42813034527344 1 11.1518634542482 2398 4626 4101 4557 1414 3106 2680 4165 2972 4484 4101 4501 M14421 GO_KETONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 24/38 Gene Ontology BP GO:0042181 5.99978263211664e-06 7.3407805909121e-06 4515 4018.18181818182 4103 5.45436272239077e-07 3069 1.95192488192316 2.11116033119563 1 12.0172419646784 4513 4491 3069 4539 3773 3722 3548 3672 4289 4103 4481 4502 M15577 GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. 282/364 Gene Ontology BP GO:0006091 1.15036101972408e-06 1.66748592672155e-06 1945 3708.54545454545 4104 1.04578329203489e-07 1945 1.1615065448187 1.1215783648367 1 8.01344393725019 1945 4635 4212 4629 3174 2695 2463 4378 4104 4576 3983 4503 M16645 GO_ORGANELLE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_DISASSEMBLY.html The disaggregation of an organelle into its constituent components. 197/263 Gene Ontology BP GO:1903008 1.27964082814331e-07 4.17034908558357e-07 4200 3509.45454545455 4104 1.16330991143115e-08 1316 1.98465200962802 2.30665713198116 1 15.2101140577222 4197 4121 2765 4104 1316 4217 4229 4140 1435 4094 3986 4504 M11638 GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. 8/15 Gene Ontology BP GO:0045628 0.000255284853031395 0.000268135535249454 2370 3764.63636363636 4105 2.55314184434103e-05 2370 2.35813219999055 -2.35813219999055 -1 10.0830855624936 2370 4105 4318 3081 4418 3695 4127 4123 4336 3797 3041 4505 M13414 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS.html Splicing of RNA via a series of two transesterification reactions. 291/364 Gene Ontology BP GO:0000375 2.22061676344218e-05 2.50364182221867e-05 1050 3386.90909090909 4105 2.01876288911476e-06 1049 0.839576671575416 0.867688963385075 1 4.56924822241339 1049 4637 4204 4641 4105 2099 1348 2935 4448 4625 3165 4506 M11656 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL.html A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. 109/138 Gene Ontology BP GO:0070646 2.25140862384006e-05 2.53774329620344e-05 4110 3658.90909090909 4106 2.04675605850507e-06 2177 1.16823488536931 -1.40182719969047 -1 6.3899149979088 2177 4381 4139 4613 4106 3316 2613 2811 4107 4549 3436 4507 M13668 GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. 463/607 Gene Ontology BP GO:0033157 1.0674559151198e-07 4.02645553947883e-07 4615 3605.90909090909 4108 9.70414515375944e-09 1098 1.72703383340055 1.82801955748216 1 13.2542486873701 4614 3876 3579 3338 1098 4194 4451 4251 1977 4179 4108 4508 M13221 GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. 37/44 Gene Ontology BP GO:0070911 0.185698202387047 0.186379149203393 4640 3575.81818181818 4109 0.0185016333068599 1637 0.621253015868493 0.63452030772128 1 0.445223148598047 2572 4219 4109 4286 4640 2312 1637 3188 4640 4622 3109 4509 M10177 GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity. 31/37 Gene Ontology BP GO:1904030 2.98984704911286e-06 3.86652538063428e-06 4570 4002.27272727273 4110 2.71804646580606e-07 3112 2.07046591684445 2.57913559693954 1 13.4504772301913 4569 4479 3112 4179 3573 4499 4633 4110 3319 4078 3474 4510 M15131 GO_HISTONE_H4_K16_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K16_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. 21/21 Gene Ontology BP GO:0043984 1.12161400601101e-05 1.31226300476973e-05 3755 4111.45454545455 4110 1.01965429483215e-06 3754 0.803279171947129 -0.533968912189834 -1 4.63980531214683 3754 4266 3977 4571 3956 3760 3776 4168 4532 4356 4110 4511 M10934 GO_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLATION.html The modification of histones by addition of methyl groups. 81/94 Gene Ontology BP GO:0016571 2.40684718855276e-05 2.70835791253592e-05 2605 3652.45454545455 4112 2.18806683670961e-06 1509 1.03297609364348 -1.02890543639071 -1 5.60286451974664 2601 4396 4116 4437 4112 2727 1509 3852 4386 4461 3580 4512 M11531 GO_BLASTOCYST_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_FORMATION.html The initial formation of a blastocyst from a solid ball of cells known as a morula. 25/34 Gene Ontology BP GO:0001825 0.0185012191884828 0.0187021883302217 3910 3959.36363636364 4113 0.00169624224630816 2726 1.22269214197185 -1.63524860695291 -1 2.45243051540671 3907 4498 3747 4528 4584 4113 4352 2726 4016 4338 2744 4513 M15534 GO_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERAD_PATHWAY.html The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. 91/99 Gene Ontology BP GO:0036503 5.01950759722842e-05 5.50324430959091e-05 2115 3780.45454545455 4114 4.56329284153554e-06 2114 1.12639693527528 -0.826054908305641 -1 5.69943306047998 2114 4392 4114 4611 4217 3285 3189 3634 4257 4471 3301 4514 M16731 GO_REGULATION_OF_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING.html Any process that modulates the frequency, rate or extent of protein targeting. 362/501 Gene Ontology BP GO:1903533 1.04042688875064e-07 4.02645553947883e-07 4410 3640.81818181818 4117 9.45842670867859e-09 1062 1.69731692652185 1.68936976603748 1 13.0244125060244 4407 4117 3636 3831 1062 4408 4300 4185 2338 4195 3570 4515 M13701 GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of B cell apoptotic process. 19/27 Gene Ontology BP GO:0002902 1.80221976001587e-06 2.46132331768531e-06 4555 3706.90909090909 4118 1.6383829421631e-07 2515 1.89995158879986 -1.77944662407795 -1 12.7849946563856 4551 4247 2661 4125 3376 4605 2923 3084 4118 2515 4571 4516 M14704 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE.html The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. 45/50 Gene Ontology BP GO:0006120 0.0799895342299187 0.0804390107568212 1100 3611.36363636364 4119 0.00755046305970817 1097 0.7628388904322 0.799843502664871 1 0.906831597960033 1097 4458 4119 4596 4612 2575 1779 3568 4585 4503 3833 4517 M11783 GO_AEROBIC_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AEROBIC_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. 59/63 Gene Ontology BP GO:0009060 5.13130736338197e-05 5.61391327576213e-05 1980 3680.90909090909 4120 4.66493368231037e-06 1979 0.881208241498208 0.840348349625459 1 4.42718111408163 1979 4418 4120 4269 4226 2483 2480 4163 3855 4477 4020 4518 M15043 GO_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. 630/813 Gene Ontology BP GO:0016071 2.02927971182508e-06 2.73291997080234e-06 3655 4150.63636363636 4121 2.02928156491672e-07 3465 0.956359970261686 1.03379354013459 1 6.33174636217536 3653 4615 4533 4649 3465 3797 3858 4121 4249 4638 4079 4519 M10377 GO_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. 61/78 Gene Ontology BP GO:0031060 2.59730409937654e-05 2.91351397647036e-05 3105 3930.63636363636 4124 2.3612134213344e-06 2692 1.1740021116631 -1.08201641430383 -1 6.33682169074594 3105 4419 4057 4427 4124 3281 2692 4538 4265 4216 4113 4520 M14979 GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS.html The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. 21/26 Gene Ontology BP GO:0006607 0.0152817234815346 0.0154611566339597 3805 4081.54545454545 4124 0.00139899253325747 3297 1.2616844674996 0.930980684094263 1 2.66003773980496 3804 4268 3922 4042 4579 3844 3297 4158 4124 4259 4600 4521 M14810 GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. 76/107 Gene Ontology BP GO:0048024 0.000113244869364545 0.000120855132374593 1000 3317.72727272727 4125 1.02955180961447e-05 997 0.957060421531589 1.04679826605635 1 4.43168843906425 997 4411 4125 4293 4332 2337 1767 2553 4506 4529 2645 4522 M15586 GO_PROTEIN_ACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACYLATION.html The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. 160/188 Gene Ontology BP GO:0043543 3.06728185463909e-06 3.95567141619615e-06 4210 3990 4130 2.78844193737287e-07 3536 1.19924644418973 -1.28868503131522 -1 7.73304740848568 3599 4358 4130 4418 3583 4206 4208 3536 3711 4479 3662 4523 M16077 GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 674/855 Gene Ontology BP GO:1903827 6.74910662105462e-08 4.02645553947883e-07 4580 3249.63636363636 4132 6.7491068260316e-09 641 1.74625233489532 1.89429355770262 1 13.402888214787 4580 1410 4592 1873 641 4132 4376 4539 1619 3600 4384 4524 M12046 GO_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). 147/171 Gene Ontology BP GO:0045333 0.0697275719847905 0.0701648772589166 1095 3652 4133 0.00654916940034041 1091 0.944669804887595 0.924982881109016 1 1.21532861435369 1091 4365 4183 4616 4609 2620 2261 3803 4133 4575 3916 4525 M13203 GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE.html Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 35/43 Gene Ontology BP GO:0072595 9.3783385158133e-05 0.000100709460221739 3850 4009.36363636364 4138 8.52612575190777e-06 2790 1.03781279791582 1.19511888749494 1 4.91370077824741 3848 4465 3963 3356 4308 3920 4524 2790 4512 4279 4138 4526 M11195 GO_VESICLE_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_TARGETING.html The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. 110/125 Gene Ontology BP GO:0006903 5.78197479530161e-07 9.88010603104605e-07 4140 3805.09090909091 4139 5.25634210445787e-08 2568 1.65893856928615 2.13923820650901 1 11.9454474529052 4140 3901 3315 4251 2681 4635 3679 4383 2568 4139 4164 4527 M10989 GO_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 816/1046 Gene Ontology BP GO:0043549 9.61904313252931e-08 4.02645553947883e-07 4485 3244.45454545455 4140 9.6190435488963e-09 983 1.96731152831678 2.15718410156383 1 15.1126018493425 4481 2323 4272 2498 1087 4355 4140 4394 2862 983 4294 4528 M16950 GO_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MITOCHONDRION.html The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. 60/69 Gene Ontology BP GO:0006626 5.21464753055993e-05 5.69571712668905e-05 1265 3421.36363636364 4141 4.74070103377871e-06 1261 0.915919158118344 0.896251830823459 1 4.59866449809876 1261 4430 4141 4598 4232 2185 1505 3177 4408 4501 3197 4529 M14029 GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION.html The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. 77/108 Gene Ontology BP GO:0006369 2.82670213572115e-05 3.15865634906593e-05 1430 3383.45454545455 4142 2.56976223242707e-06 1126 0.731920363970935 0.671943403565019 1 3.88080412882842 1430 4408 4177 4447 4142 1737 1126 3405 4561 4532 3253 4530 M14218 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. 61/67 Gene Ontology BP GO:0000288 2.870216002745e-05 3.20497121688805e-05 3720 4135.27272727273 4145 2.60932131774494e-06 3720 0.749604505372654 0.801085787981467 1 3.97132585139652 3720 4170 4135 4426 4145 3796 4047 3760 4439 4518 4332 4531 M12741 GO_REGULATION_OF_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBRINOLYSIS.html Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. 9/20 Gene Ontology BP GO:0051917 0.00483263725862778 0.00492471773201819 3735 4057.54545454545 4147 0.000484317901007557 3403 2.60849264778772 2.27603770873817 1 7.17689618052633 3403 4326 4386 3970 4552 3733 3734 4359 4501 3522 4147 4532 M13532 GO_TETRAPYRROLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 51/86 Gene Ontology BP GO:0033013 9.0577295029659e-07 1.38591303443934e-06 4610 4033.27272727273 4147 8.23430293833722e-08 3003 1.39685824950841 1.45563694457718 1 9.79373950587127 4610 4172 3540 4518 3003 3854 3687 4634 3591 4147 4610 4533 M13835 GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. 72/76 Gene Ontology BP GO:0030433 0.000188994387792714 0.000199725388689415 1445 3585.45454545455 4151 1.71827841454156e-05 1443 0.848386689558757 -0.792247607549424 -1 3.69293309195157 1443 4407 4151 4291 4383 2824 2641 3378 4451 4493 2978 4534 M10252 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS.html The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. 62/67 Gene Ontology BP GO:0097031 0.0478673595671376 0.0482405943395909 1215 3605.09090909091 4153 0.00444924770486763 1214 0.743747190789986 0.810502992095495 1 1.08129392631789 1214 4432 4153 4603 4600 2474 1664 3587 4579 4533 3817 4535 M13411 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. 62/67 Gene Ontology BP GO:0032981 0.0478673595671376 0.0482405943395909 4605 3607.36363636364 4154 0.00444924770486763 1215 0.743747190789986 0.810502992095495 1 1.08129392631789 1215 4433 4154 4604 4601 2475 1665 3602 4580 4534 3818 4536 M15182 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. 933/1288 Gene Ontology BP GO:0045944 1.39787512306153e-07 4.25953696634269e-07 4475 3890.36363636364 4154 1.397875210994e-08 1533 1.67837973193481 1.71395368579629 1 12.8283407115024 4474 3624 4541 4382 1533 4367 4154 3775 3614 3968 4362 4537 M11322 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_ELONGATION.html Any process that modulates the frequency, rate, extent or accuracy of translational elongation. 25/25 Gene Ontology BP GO:0006448 1.43688976663803e-05 1.65860781051024e-05 4030 4138.45454545455 4155 1.30627195591507e-06 3945 0.93190398617872 -0.793005018420311 -1 5.28459278938804 4029 4237 3945 4234 4005 4039 3974 4412 4155 4337 4156 4538 M15064 GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. 62/67 Gene Ontology BP GO:0010257 0.0478673595671376 0.0482405943395909 4605 3609.36363636364 4155 0.00444924770486763 1216 0.743747190789986 0.810502992095495 1 1.08129392631789 1216 4434 4155 4605 4602 2476 1666 3614 4581 4535 3819 4539 M11714 GO_PROTEIN_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLATION.html The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 113/135 Gene Ontology BP GO:0006479 6.6241885420317e-05 7.1713237054615e-05 3235 3815.90909090909 4156 6.02217091310171e-06 2350 1.01593491534327 -1.10181627150479 -1 4.98913877502058 3232 4377 4156 4444 4267 2964 2350 4074 4416 4488 3207 4540 M11920 GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. 69/99 Gene Ontology BP GO:1990542 0.000977278590628287 0.00100781854658542 2120 3758.72727272727 4157 8.88829986451628e-05 2059 1.04163485618344 0.858393968784248 1 3.67203256785564 2119 4413 4117 4435 4488 2771 2059 4202 4157 4496 4089 4541 M16145 GO_PROTEIN_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALKYLATION.html The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 113/135 Gene Ontology BP GO:0008213 6.6241885420317e-05 7.1713237054615e-05 3235 3808.09090909091 4157 6.02217091310171e-06 2351 1.01593491534327 -1.10181627150479 -1 4.98913877502058 3233 4378 4157 4445 4268 2965 2351 3978 4417 4489 3208 4542 M13293 GO_ELECTRON_TRANSPORT_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_TRANSPORT_CHAIN.html A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 92/110 Gene Ontology BP GO:0022900 0.0779785236790761 0.0784506098764845 1000 3625.81818181818 4161 0.00735344492065388 1000 0.929208632784449 0.859911136649166 1 1.1392754525595 1000 4393 4161 4601 4610 2686 1844 3836 4219 4563 3971 4543 M12850 GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. 18/18 Gene Ontology BP GO:0035024 1.60309489854809e-05 1.84041464666771e-05 3580 4036.18181818182 4162 1.45736961826467e-06 3395 1.41689793392011 1.36079795862855 1 8.01104762769561 3580 4524 3395 4509 4027 4308 4170 4162 4345 3778 3600 4544 M16958 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 58/73 Gene Ontology BP GO:0090502 5.26343415556334e-07 9.19322790008868e-07 4540 3926 4163 4.78494128620422e-08 2618 1.35770652000835 1.09113460703971 1 9.80906788389347 4540 4426 3902 4551 2618 4046 4166 3256 3289 4229 4163 4545 M15034 GO_RNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYADENYLATION.html The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. 32/35 Gene Ontology BP GO:0043631 9.62776477763505e-06 1.13873893010513e-05 3485 4081.72727272727 4165 8.75255173769406e-07 3225 0.735022576848288 -0.869952991146209 -1 4.29155657331673 3482 4475 4069 4581 3907 4165 4397 3225 4554 4428 3616 4546 M15067 GO_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that modulates the frequency, rate or extent of translational initiation. 89/99 Gene Ontology BP GO:0006446 0.00160209082128736 0.00164522811552639 2060 3644.36363636364 4165 0.000145750790151316 2057 1.09241998900678 -1.18895957843809 -1 3.57488026408934 2057 4402 4165 4624 4514 2820 2076 3426 4290 4558 3156 4547 M10468 GO_CELLULAR_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 56/70 Gene Ontology BP GO:0006073 1.16441269042045e-07 4.08548528935279e-07 4145 3908.27272727273 4167 1.05855704731847e-08 1210 1.2019205445186 1.08091697082826 1 9.18373531102343 4141 4167 3823 4030 1210 4469 4540 4205 3556 4317 4533 4548 M11776 GO_CRISTAE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRISTAE_FORMATION.html The assembly of cristae, the inwards folds of the inner mitochondrial membrane. 12/13 Gene Ontology BP GO:0042407 0.0516725265191002 0.0520528828519968 3370 3939.90909090909 4167 0.00481160516271123 2114 0.770607864736371 -0.776694821490016 -1 1.09327856870605 3367 4312 3871 4039 4604 3423 2114 4167 4498 4610 4334 4549 M16641 GO_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOLYSIS.html The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. 1051/1543 Gene Ontology BP GO:0006508 7.35690164796971e-08 4.02645553947883e-07 4170 3799.81818181818 4167 7.35690189152773e-09 751 1.81693491777415 -1.69508920890988 -1 13.9495606865495 4167 4335 4641 4154 751 4501 3844 4144 2522 4344 4395 4550 M12331 GO_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 56/70 Gene Ontology BP GO:0044042 1.16441269042045e-07 4.08548528935279e-07 4145 3913.90909090909 4168 1.05855704731847e-08 1211 1.2019205445186 1.08091697082826 1 9.18373531102343 4142 4168 3824 4031 1211 4470 4541 4257 3557 4318 4534 4551 M15293 GO_NUCLEUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. 151/272 Gene Ontology BP GO:0006997 8.07730122749683e-08 4.02645553947883e-07 4255 3831.27272727273 4169 7.34300138550457e-09 747 1.22813807651964 1.46558082566852 1 9.39569449399184 4251 3892 4105 4573 747 4169 4594 3849 3390 4375 4199 4552 M10357 GO_AMINO_ACID_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_ACTIVATION.html The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. 52/52 Gene Ontology BP GO:0043038 0.000296446033605391 0.000310248176870419 4180 4231.81818181818 4178 2.69532715192009e-05 3921 0.71154331132733 0.556110825598158 1 2.91606178437534 3921 4178 4134 4421 4423 4370 4003 4177 4467 4507 3949 4553 M12919 GO_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_PHOSPHORYLATION.html The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 83/99 Gene Ontology BP GO:0006119 0.10440553657719 0.104924181791288 1515 3749.72727272727 4180 0.00997424903282047 1511 0.729266959472889 0.722856133743007 1 0.760604004408782 1511 4404 4180 4620 4614 2956 1996 3794 4544 4574 4054 4554 M13204 GO_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an mRNA molecule. 86/117 Gene Ontology BP GO:0031124 1.71715961052008e-05 1.96168516271789e-05 3020 3960.18181818182 4182 1.56106637596598e-06 2553 0.736912933081934 0.621454608556947 1 4.09234766359645 3016 4399 4182 4619 4045 2853 2553 4638 4547 4553 4157 4555 M14406 GO_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_GENE_SILENCING.html The inactivation of gene expression by a posttranscriptional mechanism. 50/58 Gene Ontology BP GO:0016441 7.60950240728416e-06 9.12787179713668e-06 4235 4131.54545454545 4187 6.91775338877374e-07 3048 0.938599204141884 1.13812736309084 1 5.61772521966633 4235 4187 4097 4285 3854 4569 4063 3048 4526 4456 4127 4556 M11089 GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 311/351 Gene Ontology BP GO:0045732 1.3217625588689e-07 4.20399283289481e-07 4065 3807.45454545455 4188 1.20160239843687e-08 1357 1.46765171800851 -1.26911156375397 -1 11.2148769779893 4188 3632 4065 4062 1357 4599 4508 4276 2339 4417 4439 4557 M10044 GO_TRNA_AMINOACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_AMINOACYLATION.html The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. 52/52 Gene Ontology BP GO:0043039 0.000296446033605391 0.000310248176870419 3920 4232.09090909091 4190 2.69532715192009e-05 3920 0.71154331132733 0.556110825598158 1 2.91606178437534 3920 4177 4133 4420 4422 4369 4002 4190 4466 4506 3948 4558 M13619 GO_OXYGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORT.html The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/19 Gene Ontology BP GO:0015671 0.734443259316415 0.734443259316415 4130 4236.45454545455 4191 0.124178236312335 3650 1.01453737084317 1.01453737084317 1 0.0615085871584044 4128 4597 4439 4529 4648 3650 3992 3784 4653 3990 4191 4559 M10353 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. 19/23 Gene Ontology BP GO:0033962 0.000361655373775407 0.000377728945943203 3265 4059.63636363636 4192 3.28831672324311e-05 3262 0.929032605628536 -0.852852345229449 -1 3.7428182757484 3262 4531 3809 4246 4434 3569 3312 4640 4499 4192 4162 4560 M10904 GO_NEGATIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPAIR.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. 15/17 Gene Ontology BP GO:0045738 0.00119708960262751 0.00123122412047432 4195 3979.09090909091 4192 0.000108885588508403 3083 1.3048041810966 -1.14366440359591 -1 4.48856794593314 4293 4298 3647 3816 4504 4195 3422 3083 4528 3792 4192 4561 M11131 GO_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. 110/119 Gene Ontology BP GO:0032543 0.467611765038764 0.468517989389614 4195 3789.36363636364 4195 0.0556963306989325 1448 0.730975367580659 0.707538813515263 1 0.188133238446526 1448 4394 4191 4633 4644 2867 2111 4195 4597 4586 4017 4562 M10780 GO_PROTEIN_N_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. 67/81 Gene Ontology BP GO:0006487 1.42222080083815e-07 4.2854237685504e-07 4240 3798.45454545455 4196 1.2929280843451e-08 1441 1.5278174786685 1.81940916564942 1 11.6634518219466 4240 3466 3621 4493 1441 4570 4196 4579 2987 3953 4237 4563 M12841 GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. 18/19 Gene Ontology BP GO:0007007 0.68618940391 0.68633690808109 3190 4013.09090909091 4197 0.1 2581 0.791135539830681 0.800762685391124 1 0.0534428059219796 3189 4560 4001 4065 4636 3515 2581 4197 4537 4620 4243 4564 M14803 GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 40/51 Gene Ontology BP GO:0046685 0.000186399236627782 0.000197072403551254 3930 3986.09090909091 4198 1.69468210486953e-05 3252 1.74350905298331 -1.73948025668585 -1 7.71017647847956 3928 4198 3252 4211 4382 4583 4222 4238 3620 3762 3451 4565 M16669 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN.html The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. 14/23 Gene Ontology BP GO:0006123 0.679527216116911 0.680258204946641 2890 4015.81818181818 4203 0.0982795418892627 2816 0.508775586569674 -0.354724327442038 -1 0 2887 4584 3959 4569 4638 3535 2816 3702 4628 4653 4203 4566 M16029 GO_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group. 57/62 Gene Ontology BP GO:0043967 7.05112326159817e-06 8.48871320471314e-06 4085 4223.90909090909 4205 6.41013260085881e-07 3838 0.9301386222607 0.936751223725201 1 5.60162438946297 4085 4425 4087 4419 3838 4114 4220 4187 4205 4372 4511 4567 M13488 GO_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BROWN_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 34/40 Gene Ontology BP GO:0050873 5.76027613321497e-05 6.27400862543288e-05 4545 3761.27272727273 4206 5.23675178225108e-06 2202 2.35578717208878 -2.08590878710631 -1 11.8701839075483 4543 4206 2202 3870 4244 4372 3522 4222 3127 2806 4260 4568 M14270 GO_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_ELONGATION.html The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. 109/123 Gene Ontology BP GO:0006414 0.00013702400964341 0.000145631045425031 1770 3795 4206 1.24575040674405e-05 1769 0.80896247471071 0.836233654175088 1 3.65074979517253 1769 4391 4206 4451 4352 3080 2369 4104 4489 4565 3969 4569 M14381 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. 476/602 Gene Ontology BP GO:0022613 2.33050858212347e-05 2.62436022086653e-05 3170 4134.45454545455 4207 2.11866660916515e-06 3169 0.792530787686511 0.790448758986873 1 4.28783780920879 3169 4622 4207 4650 4110 3620 3847 3915 4485 4631 4223 4570 M15817 GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. 35/49 Gene Ontology BP GO:1901186 0.000304718890044663 0.000318691165515355 4555 4004.90909090909 4211 2.77055549466789e-05 2822 1.51401838475277 1.59361546218035 1 6.29954585408382 4552 4211 3445 2822 4427 4630 3632 4224 3823 3644 4644 4571 M14513 GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organonitrogen compound. 1625/2218 Gene Ontology BP GO:1901564 9.06264704330513e-08 4.02645553947883e-07 4525 3861.18181818182 4212 9.06264741289722e-09 998 1.7143948889009 1.7639959322395 1 13.1564966988507 4523 3869 4498 4462 998 4070 4212 4471 2612 4161 4597 4572 M15006 GO_REGULATION_OF_TRANSLATIONAL_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_FIDELITY.html Any process that modulates the ability of the translational apparatus to interpret the genetic code. 16/16 Gene Ontology BP GO:0006450 4.96417709197336e-05 5.44771603984718e-05 3935 4186.36363636364 4214 4.51299009944978e-06 3334 0.523751840766092 -0.516444120618613 -1 2.59782664992017 3932 4564 3972 4063 4214 3709 3334 4506 4627 4637 4492 4573 M15204 GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 15/22 Gene Ontology BP GO:0006700 8.65040655324439e-07 1.33456040093654e-06 4040 3882.90909090909 4215 7.86400904962609e-08 2975 2.09511902944739 3.04597803801139 1 14.7824445615409 4040 4286 3039 4215 2975 4240 3322 4531 4258 3476 4330 4574 M14713 GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. 27/27 Gene Ontology BP GO:0009081 0.538235544602418 0.539046489245598 4220 3921.18181818182 4219 0.0678350423693957 2877 1.13897501427007 -0.553212364480594 -1 0.26671992924478 4219 4489 3859 4579 4634 3109 3092 4399 2877 4369 3507 4575 M15325 GO_COENZYME_A_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 11/11 Gene Ontology BP GO:0015937 8.13407770430454e-05 8.7631080245726e-05 4510 4016.54545454545 4219 7.39488951071101e-06 2733 0.85956920564477 0.867322103850288 1 4.11489536960071 4508 2733 3620 4333 4290 4266 4219 3981 4243 4033 3956 4576 M10203 GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT.html The directed movement of substances from endoplasmic reticulum to cytosol. 24/32 Gene Ontology BP GO:1903513 0.000579889729235316 0.00060120920457485 4430 4036.63636363636 4220 5.27311487834505e-05 3297 1.13076278463359 -0.736347478768961 -1 4.30185835434736 4428 4232 3839 3331 4465 4102 4296 3673 3297 4220 4520 4577 M12683 GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin receptor signaling. 16/20 Gene Ontology BP GO:0046628 0.000217152093257462 0.00022885814041381 4230 3955.72727272727 4227 1.97430482113759e-05 2987 1.97217926113908 -1.31505753188282 -1 8.58001650252635 4227 4066 2987 3102 4396 4589 4423 3395 4411 3584 4333 4578 M13027 GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION.html Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. 23/34 Gene Ontology BP GO:0060142 9.77996605043626e-07 1.46651756796557e-06 4485 3878.81818181818 4228 8.89088218005757e-08 2409 2.16621314359498 -2.64764014887312 -1 15.1802752548479 4317 3995 2409 4484 3066 4339 4408 4483 3840 3098 4228 4579 M12629 GO_TELOMERE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_LOCALIZATION.html Any process in which a telomere is transported to, and/or maintained in, a specific location. 7/12 Gene Ontology BP GO:0034397 0.0108380974321085 0.0109916450199654 2735 3580.63636363636 4230 0.0010891322098276 1495 0.559200558328786 0.4183999033845 1 1.22186301628225 2731 4331 4379 4230 4625 2812 1495 2160 4567 4618 3439 4580 M10436 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 1468/2161 Gene Ontology BP GO:0010629 2.62818619177725e-07 5.72075198629656e-07 4210 3966.72727272727 4232 2.62818650260862e-08 2151 1.65134814188214 1.79276982788718 1 12.3642576407208 4207 4599 4239 4422 2151 4624 3879 3266 3500 4232 4515 4581 M16116 GO_PEPTIDYL_METHIONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_METHIONINE_MODIFICATION.html The modification of peptidyl-methionine. 10/12 Gene Ontology BP GO:0018206 0.68618940391 0.68633690808109 4650 4187.18181818182 4235 0.1 3349 0.566290383203143 0.566290383203143 1 0.00899287692287965 3349 4596 3881 4567 4650 3804 3563 4235 4648 4647 4119 4582 M14637 GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 22/25 Gene Ontology BP GO:0046386 0.0072299300885934 0.00734516696555133 4580 4118.27272727273 4250 0.000659436357505161 3268 1.61774294524256 -1.67478347872383 -1 4.07219716336062 4578 4258 3639 4223 4561 4075 3572 4326 4250 3268 4551 4583 M16755 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 50/72 Gene Ontology BP GO:0032784 6.24207589085772e-05 6.77973368817949e-05 3550 4220.09090909091 4253 5.67477545887568e-06 3550 0.646320906057919 0.626901144761873 1 3.15561147117007 3550 4437 4115 4430 4253 4013 3973 4211 4624 4538 4277 4584 M12907 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. 16/16 Gene Ontology BP GO:0070198 0.000154750559876697 0.000164171079595593 4365 3878.54545454545 4256 1.40692223893841e-05 2778 0.851677530422092 0.605651493665669 1 3.79534925186609 2782 4565 3932 4256 4365 2980 2778 4476 4479 4365 3686 4585 M10731 GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA processing. 46/61 Gene Ontology BP GO:0050685 9.34821242724252e-07 1.41962246814489e-06 4495 3986.90909090909 4257 8.49837854497782e-08 3027 1.14243424109223 1.44223347553032 1 7.97673311532978 4493 3944 3793 4257 3027 4594 4267 3543 4346 4333 3259 4586 M12694 GO_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACETYLATION.html The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic 129/148 Gene Ontology BP GO:0006473 1.20903967431878e-05 1.40958697183795e-05 4390 4173.90909090909 4257 1.09913301710046e-06 3342 1.06900924329072 0.915173340485268 1 6.16857242031557 4387 4369 4150 4438 3964 4384 4257 3342 4159 4511 3952 4587 M15678 GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 12/16 Gene Ontology BP GO:0043455 0.000559570072110093 0.000580401147019229 4510 3678.18181818182 4257 5.08829499525471e-05 2471 2.57073881881072 -1.75683006874833 -1 9.95875567768371 4509 4569 2471 4498 4462 4335 2799 2611 2863 3086 4257 4588 M13081 GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). 38/42 Gene Ontology BP GO:0072350 0.000383580542881088 0.000400089725627819 3315 3898.63636363636 4261 3.48770398469515e-05 2827 1.07674584496866 0.807389609889327 1 4.3217589208172 3311 4454 4021 4261 4440 2971 3329 4609 2827 4334 4328 4589 M10426 GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. 80/93 Gene Ontology BP GO:0036498 2.0843477161785e-06 2.79955694822202e-06 4400 4092.90909090909 4265 1.89486335541482e-07 3007 0.875780933026072 -0.710229486936963 -1 5.77850269779779 3903 4400 4149 4610 3435 3739 3007 4265 4399 4504 4611 4590 M15498 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 34/37 Gene Ontology BP GO:1900101 0.000189559566081434 0.000200277170975684 4475 4277.72727272727 4265 1.72341728323711e-05 3992 0.967314019809797 0.931066252325888 1 4.22364153992712 4075 4473 3992 4079 4384 4472 4239 4064 4616 4396 4265 4591 M11937 GO_CYTOCHROME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 26/27 Gene Ontology BP GO:0017004 0.000183787343162726 0.000194487720658668 2570 3664.90909090909 4268 1.67093362271294e-05 786 0.953498868205692 -1.15067879551798 -1 4.17653956404903 2566 4495 3914 4545 4512 3720 4280 786 4414 4268 2814 4592 M14800 GO_HISTONE_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). 14/14 Gene Ontology BP GO:0071044 6.80454508628721e-05 7.36486352325991e-05 4100 4178.90909090909 4270 6.18614141662009e-06 3109 0.55699185449894 -0.588434018747771 -1 2.68102118020892 4099 3837 3938 3109 4270 4457 4447 4114 4520 4633 4544 4593 M12546 GO_ER_NUCLEUS_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_NUCLEUS_SIGNALING_PATHWAY.html Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. 46/50 Gene Ontology BP GO:0006984 7.20134731077597e-07 1.15379683847004e-06 4360 3946.81818181818 4271 6.54668151638421e-08 2860 1.72838736732583 -1.36954752586807 -1 12.3090153195995 4359 4440 3377 3834 2860 4629 3836 4426 3018 4271 4365 4594 M11453 GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 9/15 Gene Ontology BP GO:0060456 0.00264684553707526 0.00270974087657012 4325 4143.63636363636 4272 0.000265000343814685 3153 2.30897411980783 -1.35811592090242 -1 7.06550712915083 4272 4323 4302 4325 4531 4148 3153 3957 4158 3871 4540 4595 M11662 GO_TRANSLATIONAL_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_TERMINATION.html The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). 92/100 Gene Ontology BP GO:0006415 0.471501256035996 0.47231331417341 1705 3838.36363636364 4274 0.0563255902899433 1704 0.740369062889433 0.726497880018875 1 0.188736612947209 1704 4410 4195 4632 4639 2979 2116 4274 4605 4578 4090 4596 M13222 GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. 12/14 Gene Ontology BP GO:0050812 0.58505177085953 0.585807163720549 4550 4254 4276 0.0768502123285143 3836 1.05091563037924 -0.544562597475181 -1 0.192220098643231 4548 4590 3856 4051 4630 3926 4487 4089 4505 4276 3836 4597 M16400 GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html The directed movement of proteins from the endoplasmic reticulum. 24/29 Gene Ontology BP GO:0032527 0.298919744666644 0.299628085293816 3235 4196.54545454545 4278 0.0317692191419536 3234 0.603597980184346 -0.565055502677165 -1 0.279131619246361 3234 4517 4071 4278 4627 4214 4388 3650 4620 4649 3914 4598 M15564 GO_RRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. 18/20 Gene Ontology BP GO:0016075 6.77505442133826e-06 8.1838858313829e-06 3870 3955.81818181818 4286 6.1591593506217e-07 2531 0.819189188171183 0.741783492195987 1 4.93690149222515 3870 4520 3880 4379 3824 3178 2531 4329 4423 4294 4286 4599 M13062 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. 34/35 Gene Ontology BP GO:0000462 0.00447994101981378 0.00456830277562864 4235 4300.81818181818 4288 0.000408099071026129 3744 0.551260507328222 0.63783068374608 1 1.45726722246495 4234 4490 4110 4288 4546 4221 4001 3744 4626 4510 4539 4600 M11293 GO_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 585/702 Gene Ontology BP GO:0030163 1.78652876616156e-07 4.70925331038116e-07 4615 3955.81818181818 4292 1.7865289097874e-08 1773 1.38244808040396 -1.21682111265835 -1 10.4754173645501 4058 4613 4292 4607 1773 4320 4105 4008 2574 4552 4612 4601 M10864 GO_MATURATION_OF_SSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. 43/44 Gene Ontology BP GO:0030490 0.018984147225985 0.0191820275879497 3305 4188.81818181818 4294 0.00174090647371958 3303 0.553561683754858 0.630748823387132 1 1.04660316466219 3303 4470 4140 4294 4586 3663 4582 3590 4632 4541 4276 4602 M11412 GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. 1467/2173 Gene Ontology BP GO:0051172 3.29258466441261e-07 6.66639210726007e-07 4300 4036.54545454545 4299 3.29258515226283e-08 2327 1.63238896889899 1.7875504141464 1 12.089959368076 4499 4600 4298 4424 2327 4371 4071 3715 3419 4379 4299 4603 M10435 GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 24/25 Gene Ontology BP GO:0043555 0.0264234657655778 0.0266699319321548 3665 4144.54545454545 4301 0.0024314791231949 3611 1.17250474089507 -1.13245859924665 -1 2.1289810960887 3663 4510 3948 4410 4593 4301 3611 3743 4412 4397 4002 4604 M14724 GO_UBIQUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. 13/13 Gene Ontology BP GO:0006743 0.000121224900759853 0.000129134492498991 3400 3939.81818181818 4301 1.102105282157e-05 2957 0.83012084912639 0.833630856106383 1 3.80134556758758 3397 4301 3806 4371 4342 2957 2979 4446 4553 4308 3878 4605 M15206 GO_STEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 43/70 Gene Ontology BP GO:0016126 0.000343000390847703 0.000358405753113488 4435 4231.54545454545 4305 3.11867163148401e-05 3629 1.2039661167287 -1.26640180363022 -1 4.91412522387293 4526 3950 3960 3629 4432 4464 4432 4305 4074 4282 4493 4606 M13224 GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. 47/63 Gene Ontology BP GO:1903312 9.35767304512524e-05 0.000100510740256158 4460 4275.72727272727 4307 8.50733736027761e-06 3874 0.879748452576899 -0.854153396738782 -1 4.15054996826481 4185 4446 4095 4585 4307 3874 3954 4233 4460 4437 4457 4607 M16444 GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that activates or increases the frequency, rate or extent of gluconeogenesis. 13/18 Gene Ontology BP GO:0045722 0.0151805529206797 0.0153621384819319 4635 4116.72727272727 4310 0.00138966597960529 3113 1.07687238246 1.27470446116486 1 2.25894696038354 4632 4096 3818 3113 4578 4120 3152 4407 4419 4310 4639 4608 M12650 GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. 11/11 Gene Ontology BP GO:0070129 0.00509587992577767 0.00518729584218847 3130 3881.81818181818 4315 0.000464338361657888 1941 0.639819058936341 0.583034353421552 1 1.66521048843668 3129 4588 3798 4535 4550 2716 1941 4315 4610 4619 3899 4609 M14164 GO_REGULATION_OF_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTON_TRANSPORT.html Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/21 Gene Ontology BP GO:0010155 0.000294659533826155 0.000308517284179365 4315 3997.18181818182 4315 2.67908187992716e-05 1721 1.541625940473 -1.6658841790704 -1 6.44256401410853 4315 4571 3456 3989 4421 3849 4510 1721 4445 4090 4602 4610 M14934 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. 42/45 Gene Ontology BP GO:0006383 6.86656024845406e-07 1.11363209606332e-06 4150 4110 4318 6.24232944692809e-08 2824 0.732226548774396 -0.66879314539464 -1 5.16896697179434 4146 4455 4100 4423 2824 4318 4111 3487 4531 4491 4324 4611 M16727 GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. 19/19 Gene Ontology BP GO:0006515 0.0029721045544172 0.00303871731305279 4195 4052 4323 0.000270557031750561 1746 0.853776550244772 -1.13416324164607 -1 2.49630314570476 4195 4557 4025 4068 4534 3539 1746 4632 4455 4323 4498 4612 M10881 GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. 14/20 Gene Ontology BP GO:0000380 0.0126343163830108 0.0127965768676859 4590 4319.27272727273 4327 0.00115522385533679 3693 0.64714141317564 -0.59048815109355 -1 1.37852732218074 4590 4299 3929 4043 4573 4248 3693 4653 4514 4327 4643 4613 M10121 GO_HEMOGLOBIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. 11/15 Gene Ontology BP GO:0020027 0.0123994450056151 0.0125641588874405 4450 4027.90909090909 4332 0.00113362600987901 2340 0.863658652658698 -0.723418494745744 -1 1.88250965926442 4446 4101 3487 3814 4571 4332 4422 2340 4606 3746 4442 4614 M11983 GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. 32/44 Gene Ontology BP GO:0006778 0.000126768385809818 0.000134916125153953 4125 4175.90909090909 4347 1.15250628223867e-05 3601 1.30056604362322 1.7126637462013 1 5.98406907598104 4124 4469 3656 4561 4347 4006 3831 4580 3601 4374 4386 4615 M11272 GO_RRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. 279/371 Gene Ontology BP GO:0016072 2.64442532736113e-05 2.96351422163087e-05 4340 4423.36363636364 4348 2.40405192199356e-06 4128 0.756083838585978 0.761386929500204 1 4.03764805996568 4340 4641 4193 4646 4128 4313 4348 4344 4524 4606 4574 4616 M10424 GO_RIBOSOME_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. 326/424 Gene Ontology BP GO:0042254 0.000127181261476819 0.00013532458487346 4350 4271.27272727273 4349 1.15626013070868e-05 3524 0.753531699785665 0.766704474608181 1 3.42259302323419 3524 4636 4185 4647 4348 3870 4370 3934 4527 4594 4349 4617 M10958 GO_TRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. 174/180 Gene Ontology BP GO:0006399 1.64673425885193e-05 1.88586131096186e-05 4525 4281.36363636364 4360 1.49704235003951e-06 3737 0.806980347723147 0.723622756735381 1 4.50795517322835 4522 4360 4187 4457 4035 3972 3737 4124 4486 4588 4627 4618 M13770 GO_OXIDATION_REDUCTION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATION_REDUCTION_PROCESS.html A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. 756/1065 Gene Ontology BP GO:0055114 1.01396926193675e-07 4.02645553947883e-07 4460 3996.54545454545 4361 1.01396930820277e-08 1170 1.55061090475934 -1.57716696002141 -1 11.889760371469 4357 4110 4448 4485 1170 4331 4456 4460 3231 4361 4553 4619 M16946 GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 33/50 Gene Ontology BP GO:0010907 0.000341133679661225 0.000356535267624366 4555 4082.09090909091 4371 3.10169625087201e-05 3211 1.58715903954813 1.71388192914968 1 6.51530188493772 4554 4468 3603 3345 4431 4528 3851 3211 4371 4141 4400 4620 M15974 GO_MACROMOLECULE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_METHYLATION.html The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. 188/226 Gene Ontology BP GO:0043414 1.46445694175398e-05 1.69000946180091e-05 4115 4312.45454545455 4379 1.33133335471073e-06 3803 1.01742177582521 0.994741111437615 1 5.76896805253098 4115 4651 4215 4453 4006 4261 3803 4599 4379 4548 4407 4621 M16373 GO_TRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_PROCESSING.html The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. 112/118 Gene Ontology BP GO:0008033 1.11086636107317e-05 1.30034243473546e-05 4480 4276.45454545455 4385 1.00988360937559e-06 3762 0.883776320929146 0.851460945348796 1 5.1193167708777 4621 4385 4218 4450 3953 4030 3762 4113 4477 4556 4476 4622 M14685 GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. 381/456 Gene Ontology BP GO:0034248 3.47753520853409e-07 6.91494501081586e-07 4630 4142 4387 3.16139614384313e-08 2282 1.41120502955497 1.47715470961806 1 10.410721664122 4452 4627 4174 4630 2282 4387 4249 4444 3428 4560 4329 4623 M12963 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. 59/66 Gene Ontology BP GO:0042274 0.00586740598529252 0.00596874509172849 4055 4291.90909090909 4388 0.000534828459227388 3400 0.546541850329125 -0.479176271882719 -1 1.36715295977566 4053 4448 4173 4298 4555 4539 3400 4152 4634 4571 4388 4624 M15604 GO_HEME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. 20/21 Gene Ontology BP GO:0006783 0.0225537558628423 0.022769066181342 3540 4276.36363636364 4391 0.00207166765956066 3539 0.697431018784716 -0.782322774020217 -1 1.28257423312794 3539 4539 3981 4578 4591 4268 4391 3877 4603 4426 4247 4625 M11024 GO_HEME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_METABOLIC_PROCESS.html The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. 28/37 Gene Ontology BP GO:0042168 5.26143718677345e-05 5.7441265204263e-05 4395 4255.63636363636 4393 4.78323911048898e-06 3496 1.34298121616009 1.8437044075302 1 6.78490173503227 4393 4482 3503 4544 4234 4328 4431 4588 3496 4314 4499 4626 M11907 GO_HISTONE_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEUBIQUITINATION.html The modification of histones by removal of ubiquitin groups. 23/27 Gene Ontology BP GO:0016578 0.00022235612685828 0.000234183580414572 3930 4304.45454545455 4399 2.02162367079564e-05 3914 0.726869713649167 -0.623476092092465 -1 3.0884718293806 3929 4500 3997 4553 4399 4324 4330 3914 4443 4455 4505 4627 M11099 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. 84/89 Gene Ontology BP GO:0033108 0.0215253599237572 0.0217355685167627 4405 3861.54545454545 4401 0.00197626367103152 1979 0.863305377760433 0.787954220117983 1 1.63316741708542 2187 4401 4163 4608 4587 2870 1979 4401 4490 4540 4251 4628 M12234 GO_GPI_ANCHOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GPI_ANCHOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. 31/33 Gene Ontology BP GO:0006505 0.192968427162201 0.193634266030995 3720 4202.09090909091 4404 0.0193015196683865 3196 0.812832841228891 -0.943996967201477 -1 0.597965692151072 3716 4471 4059 4404 4626 4633 4425 3196 4326 4414 3953 4629 M13137 GO_AMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 505/656 Gene Ontology BP GO:0043604 7.37685131424397e-07 1.17509377491192e-06 3830 4233.18181818182 4409 7.3768537630522e-08 2925 1.1641118912149 -1.06080410362831 -1 8.24563188833856 3830 4620 4409 4644 2925 4595 4367 3960 4128 4621 4466 4630 M10625 GO_POSITIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RNA_SPLICING.html Any process that activates or increases the frequency, rate or extent of RNA splicing. 30/44 Gene Ontology BP GO:0033120 0.00641158117883583 0.00652089338254058 3930 4335 4415 0.000584576672679726 3926 0.929580640454002 0.761637853806704 1 2.35426887924514 3926 4483 3957 4276 4557 4425 4232 4415 4593 4405 4416 4631 M13371 GO_NCRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). 550/678 Gene Ontology BP GO:0034660 5.83905171972753e-06 7.16107212754143e-06 4425 4300.27272727273 4424 5.8390670623205e-07 3806 0.845819927394859 0.818217588029788 1 5.16005171018902 4116 4618 4424 4651 3806 3882 4012 4318 4428 4624 4424 4632 M13161 GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 20/21 Gene Ontology BP GO:0002183 0.000431429398824664 0.000448690431991766 4545 4316.90909090909 4425 3.92285479280198e-05 3575 0.856369487594685 -0.616177465077619 -1 3.36459069862014 4414 4544 4011 4577 4451 4201 3575 4542 4513 4425 4233 4633 M15048 GO_PROTEIN_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSMEMBRANE_TRANSPORT.html The directed movement of a protein across a membrane by means of some agent such as a transporter or pore. 68/79 Gene Ontology BP GO:0071806 2.19742911875908e-05 2.4805040489049e-05 4430 4333.54545454545 4430 1.99768278879857e-06 3730 0.90370737637185 0.99147221745546 1 4.9305397007119 4430 4415 4124 4599 4100 4209 3730 4433 4549 4537 4543 4634 M16875 GO_TRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. 58/58 Gene Ontology BP GO:0006400 0.00037224487526919 0.000388701841253936 4445 4271.63636363636 4435 3.3846170441003e-05 3562 0.807037794119006 0.891956841678543 1 3.2256765407321 4301 4443 4152 4441 4435 3960 3562 4528 4599 4508 4059 4635 M14123 GO_RNA_SECONDARY_STRUCTURE_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SECONDARY_STRUCTURE_UNWINDING.html The process in which a secondary structure of RNA are broken or 'melted'. 40/45 Gene Ontology BP GO:0010501 0.00352223435367851 0.00359801458785206 3995 4385.27272727273 4439 0.000320716925278745 3993 0.561548036033929 -0.629971321391766 -1 1.55680468186662 3993 4477 4142 4439 4540 4510 4318 4252 4612 4629 4326 4636 M16031 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. 53/70 Gene Ontology BP GO:0042273 2.56469539143111e-05 2.87901752866803e-05 4305 4371.90909090909 4441 2.33156844580434e-06 4121 0.656314272854 -0.592051107846104 -1 3.50124313299236 4305 4441 4136 4287 4121 4475 4200 4450 4617 4509 4550 4637 M13799 GO_PROTEIN_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION.html The process in which one or more ubiquitin groups are added to a protein. 590/718 Gene Ontology BP GO:0016567 2.16327664011583e-07 5.13962042198191e-07 4575 4105.63636363636 4442 2.16327685070532e-08 1976 1.26892019038349 1.34056976523444 1 9.54842794827385 4574 4612 4449 4442 1976 4093 4536 4389 3352 4559 4180 4638 M11455 GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 26/28 Gene Ontology BP GO:0033014 0.000405162304487596 0.000422221769939706 4565 4331.18181818182 4443 3.683972184722e-05 3650 0.727338957574333 0.681519110536096 1 2.86535772895148 4565 4496 4040 4583 4443 3998 3650 4270 4587 4419 4592 4639 M10928 GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 22/28 Gene Ontology BP GO:0015986 0.00487045790431613 0.00496108595201028 3290 4061.45454545455 4444 0.00044375217077179 2454 0.659199863668485 0.56968069018313 1 1.7342080622912 3286 4511 4017 4411 4548 3339 2454 4522 4590 4444 4554 4640 M15970 GO_RESPONSE_TO_COBALT_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COBALT_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. 17/17 Gene Ontology BP GO:0032025 0.10176718103865 0.102294813863219 4470 4250 4444 0.00970946311777147 3600 1.26844477723784 1.64320220262595 1 1.41597996566273 4466 4561 3660 4262 4613 4347 4608 3600 4444 3701 4488 4641 M12843 GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. 22/28 Gene Ontology BP GO:0015985 0.00487045790431613 0.00496108595201028 4515 4061.54545454545 4446 0.00044375217077179 2455 0.659199863668485 0.56968069018313 1 1.7342080622912 3287 4512 4018 4412 4549 3340 2455 4512 4591 4446 4555 4642 M10085 GO_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. 53/70 Gene Ontology BP GO:0002181 6.506357166094e-06 7.89209590558796e-06 3925 4199 4449 5.91488764391143e-07 3323 0.718122491793901 -0.56984159083476 -1 4.32880733570179 3925 4449 4143 4606 3811 3696 3323 4513 4613 4545 4565 4643 M15919 GO_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION.html The process in which a methyl group is covalently attached to a molecule. 249/308 Gene Ontology BP GO:0032259 1.35083641298941e-05 1.56198852625241e-05 4380 4359.27272727273 4452 1.22804064310897e-06 3808 1.0438527851744 1.01595275112811 1 5.9647008660763 4378 4638 4213 4452 3996 4560 3808 4586 4282 4564 4475 4644 M16197 GO_HISTONE_H3_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_ACETYLATION.html The modification of histone H3 by the addition of an acetyl group. 46/51 Gene Ontology BP GO:0043966 0.0597072446285088 0.0601207118062003 4080 4324.72727272727 4452 0.00558109570493537 3903 0.933028169991225 -1.08671330422879 -1 1.27479357479412 4080 4452 4094 4082 4607 4483 4557 3903 4574 4460 4280 4645 M15352 GO_TROPHECTODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHECTODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. 10/14 Gene Ontology BP GO:0001829 9.08353949517125e-07 1.38894871084561e-06 4600 4161.18181818182 4465 8.257766586963e-08 3005 0.716189332577554 -0.833737425466152 -1 4.97039832544341 4597 4591 3699 4543 3005 4134 3401 4479 4647 4212 4465 4646 M14714 GO_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_HOMEOSTASIS.html Any process involved in the balance between food intake (energy input) and energy expenditure. 19/20 Gene Ontology BP GO:0097009 0.00122129023109352 0.00125583722547584 4470 4161.09090909091 4468 0.000111088066879116 2638 0.994906866230999 1.06578024800301 1 3.38771501833438 4468 4036 3499 4531 4505 4285 2638 4620 4589 4045 4556 4647 M12423 GO_NCRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_PROCESSING.html Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. 412/510 Gene Ontology BP GO:0034470 1.39326562249563e-05 1.60945008477462e-05 4225 4394.45454545455 4471 1.26661313287332e-06 4001 0.789683208887866 0.803340048731628 1 4.47486061901518 4223 4629 4200 4648 4001 4135 4479 4413 4523 4617 4471 4648 M13539 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. 223/271 Gene Ontology BP GO:0071826 1.6343273261818e-06 2.25851211201503e-06 4555 4368.45454545455 4476 1.48575321844155e-07 3337 0.794856149467854 0.829642335773595 1 5.32469528309901 4553 4649 4205 4637 3337 4198 4337 4436 4476 4626 4599 4649 M14653 GO_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ORGANELLE.html A process in which a protein is transported to, or maintained in, a location within an organelle. 637/807 Gene Ontology BP GO:0033365 1.39003074104493e-07 4.2534221883282e-07 4510 4080.81818181818 4508 1.39003082799329e-08 1526 1.32925551214976 -1.1239404572168 -1 10.1394699885996 4191 4611 4508 4639 1526 4299 3569 4625 3828 4584 4509 4650 M13360 GO_MITOCHONDRIAL_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_PROCESSING.html The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. 12/12 Gene Ontology BP GO:0000963 3.97555870312685e-05 4.3876363011502e-05 4405 4385.36363636364 4514 3.61420958741642e-06 3821 0.607224694828932 -0.616886029009143 -1 3.09728314964028 4405 4095 3821 4231 4183 4534 4588 4514 4600 4623 4645 4651 M10577 GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. 17/18 Gene Ontology BP GO:0008535 0.0677768709598517 0.0682314540407161 4575 4206 4574 0.006359969603807 2795 0.705937089916313 -0.834081503559053 -1 0.892537667337736 4644 4574 3935 4575 4621 4103 3385 2795 4618 4380 4636 4652 M16564 GO_RNA_INTERFERENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_INTERFERENCE.html The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. 12/12 Gene Ontology BP GO:0016246 0.203883963177338 0.204543355037549 4655 4450.09090909091 4584 0.0205148590168131 3933 0.446051544063464 0.446051544063464 1 0.268841478007531 4298 4595 3933 4584 4623 4608 4187 4497 4651 4652 4323 4653 M16453 GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the N-terminal amino acid residue in a protein. 22/27 Gene Ontology BP GO:0031365 0.68618940391 0.68633690808109 4590 4447.18181818182 4588 0.1 3843 0.582780725588963 0.592810568732831 1 0.012252873976918 4588 4533 4055 3843 4651 4492 4311 4592 4615 4650 4589