Smchd1 is a maternal effect gene required for autosomal imprinting


Iromi Wanigasuriya 1,2*†, Quentin Gouil 1,2†, Sarah A. Kinkel 1,2, AndrĂ©s Tapia del Fierro 1,2, Tamara Beck 1, Ellise E.A. Roper 3, Kelsey Breslin 1, Jessica Stringer 4, Karla Hutt 4, Andrew Keniry 1,2, Matthew E. Ritchie 1,2,5 and Marnie E. Blewitt 1,2


1 The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
2 Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.
3 Faculty of Health and Medicine, The University of Newcastle, NSW 2308, Australia.
4 Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia
5 School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC 3010, Australia.
Equal first author

bioRxiv preprint

The preprint of this study can be found under doi:10.1101/2020.01.20.913376


The list of mouse imprinted genes we used is here.

The list of mouse imprinted differentially methylated regions (DMRs) we used is here.

Identified Smchd1-GFP peaks.


All sequencing data are deposited on GEO under study accession PRJNA530651.

Global and allele-specific differential expression can be explored on Glimma plots, which include an MD-plot, gene counts by replicate and a summary table:

Comments/Questions? Contact Marnie Blewitt, Iromi Wanigasuriya or Quentin Gouil.
Last modified: 24th January 2020