Dr Matthew Wakefield
Senior Research Officer
+61 3 9345 2631
wakefield @ wehi.edu.au
Research Activities:
Matthew Wakefield specializes in the application of high throughput sequencing and microarray technologies to the understanding of the control and stability of gene expression.
Current projects include:
- Systems biology of chemotherapeutic drug resistance in mouse cancer models (with Clare Scott)
- Cancer genome structural variation (with Tony Papenfuss)
- Experimental design and improved analysis techniques for RNAseq
- Epigenetic stability in cancer and aging
Honours, Masters or PhD positions available. Example project: Reversing the drug resistance observed in mouse lymphomas which over-express polycomb group genes
He was an author on the proposal to sequence the genome of a model Australian marsupial (Macropus eugenii - the tammar wallaby) and continues minor involvement the genomic analysis of "non-model" organisms including tammar wallaby, opossum, platypus and coral research projects.
Selected Publications
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Young MD, Wakefield MJ, Smyth GK & Oshlack A (2010)
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Oshlack A & Wakefield MJ (2009) |
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Warren WC, Hillier LW, Graves JAM, Birney E, Ponting CP, Grutzner F, Belov K, Miller W, Clarke L, Chinwalla AT, Yang S, Heger A, Locke D, Miethke P, Waters PD, Veyrunes F, Fulton L, Graves T, Puente XS, Lopez-Otin C, Ordonez GR, Eichler EE, Chen L, Cheng Z, Deakin JE, Aslop A, Thompson K, Kirby P, Papenfuss AT, Wakefield MJ, Olender T, Lancet D, Huttley GA, Smit AF, Renfree M, Pask A, Temple-Smith P, Batzer MA, Walker JA, Konkel MK, Harris RS, Whittington CM, Wong ES, Gemmell N, Buschiazzo E, Jentzsch IV, Merkel A, Schmitz J, Zemann A, Churakov G, Kriegs JO, Brosius J, Murchison E, Sachidanandam R, Smith C, Stark A, Kheradpour P, Hannon G, Rens W, Ferguson-Smith M, Lefevre CM, Sharp JA, Nicholas KR, Ray DA, Kube M, Reinhard R, Pringle TH, Taylor J, Jones RC, Nixon B, Dacheux J, Niwa H, Sekita Y, Flicek P, Webber C, Hardison R, Washington University Genome Sequencing Center,
Mardis ER & Wilson RK. (2008)
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| New York Times ABC News BBC World The Age Nobel Intent New Scientist ABC Science Video: ABC News ABC News (Extended) Audio: ABC Radio 'AM' |
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Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SMJ, Sharpe T, Baker M, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, Hore TA, Huttley GA, Kleber M, Jirtle RL, Koina E, Lee JT, Mahony S, Marra MA, Miller RD, Nicholls RD, Oda M, Papenfuss AT, Parra ZE, Pollock DD, Ray DA, Schein JE, Speed TP, Thompson K, VandeBerg JL, Wade CM, Walker JA, Waters PD, Webber C, Weidman JR, Xie X, Zody MC, Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Graves JAM, Ponting CP, Breen M, Samollow PB, Lander ES, Lindblad-Toh K (2007)
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| ABC Online, ABC Science, BBC News, Nobel Intent, The Australian (10th May Page 8), The Sydney Morning Herald (10th May Page 12), COSMOS, New Scientist, ABC Regional - AM, The Science Show | |
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Gentles AJ, Wakefield MJ, Kohany O, Gu W, Batzer MA, Pollock DD, and Jurka J (2007)
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Knight R, Maxwell P, Birmingham A, Carnes J, Caporaso JG,
Easton BC, Hamady M, Liu Z, Lozupone C, Sammut R,
Smit S, Wakefield MJ, Widmann J, Wikman S, Wilson S,
and Huttley GA (2007)
PyCogent: a toolkit for making sense from sequence
Genome Biology 8:R171
Online Resources: PyCogent SourceForge Repository
Software
