Dr Tony Papenfuss

Senior Research Officer

(03) 9345-2627

papenfuss@wehi.edu.au

Research Activities:

Tony is a member of Terry Speed's lab. He is interested in applying mathematical and statistical methods to biological data. He mainly works in the area of biological sequence analysis, focusing especially on mammalian and parasite genomes, and comparative genomics.

Selected publications

Warren WC, Hillier LW, Marshall Graves JA, Birney E, Ponting CP, Grützner F, Belov K, Miller W, Clarke L, Chinwalla AT, Yang SP, Heger A, Locke DP, Miethke P, Waters PD, Veyrunes F, Fulton L, Fulton B, Graves T, Wallis J, Puente XS, López-Otín C, Ordóñez GR, Eichler EE, Chen L, Cheng Z, Deakin JE, Alsop A, Thompson K, Kirby P, Papenfuss AT, Wakefield MJ, Olender T, Lancet D, Huttley GA, Smit AF, Pask A, Temple-Smith P, Batzer MA, Walker JA, Konkel MK, Harris RS, Whittington CM, Wong ES, Gemmell NJ, Buschiazzo E, Vargas Jentzsch IM, Merkel A, Schmitz J, Zemann A, Churakov G, Kriegs JO, Brosius J, Murchison EP, Sachidanandam R, Smith C, Hannon GJ, Tsend-Ayush E, McMillan D, Attenborough R, Rens W, Ferguson-Smith M, Lefèvre CM, Sharp JA, Nicholas KR, Ray DA, Kube M, Reinhardt R, Pringle TH, Taylor J, Jones RC, Nixon B, Dacheux JL, Niwa H, Sekita Y, Huang X, Stark A, Kheradpour P, Kellis M, Flicek P, Chen Y, Webber C, Hardison R, Nelson J, Hallsworth-Pepin K, Delehaunty K, Markovic C, Minx P, Feng Y, Kremitzki C, Mitreva M, Glasscock J, Wylie T, Wohldmann P, Thiru P, Nhan MN, Pohl CS, Smith SM, Hou S, Renfree MB, Mardis ER, Wilson RK. Genome analysis of the platypus reveals unique signatures of evolution. Nature. 2008 May 8;453(7192):175-83. (Link)

Whittington CM, Papenfuss AT, Bansal P, Torres AM, Wong ES, Deakin JE, Graves T, Alsop A, Schatzkamer K, Kremitzki C, Ponting CP, Temple-Smith P, Warren WC, Kuchel PW, Belov K, Defensins and the convergent evolution of platypus and reptile venom genes. Genome Res. 2008 May 7 (Link)

K Belov, CE Sanderson, JE Deakin, ESW Wong, D Assange, KA McColl, A Gout, B de Bono, TP Speed, J Trowsdale, and AT Papenfuss, Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system, Genome Research, 17:982-991, 2007 (Link)

Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, Baker ML, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, Hore TA, Huttley GA, Kleber M, Jirtle RL, Koina E, Lee JT, Mahony S, Marra MA, Miller RD, Nicholls RD, Oda M, Papenfuss AT, Parra ZE, Pollock DD, Ray DA, Schein JE, Speed TP, Thompson K, VandeBerg JL, Wade CM, Walker JA, Waters PD, Webber C, Weidman JR, Xie X, Zody MC; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Graves JA, Ponting CP, Breen M, Samollow PB, Lander ES, Lindblad-Toh K, Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences, Nature, Vol 447, 10 May 2007. (Link)

E Lin, T Papenfuss, RB Tan, D Senyschyn, M Bahlo, TP Speed, and SJ Foote, Mapping of the Plasmodium chabaudi Resistance Locus char2, Infect. Immun. 2006 74: 5814-5819. (Link)

J Baum*, AT Papenfuss*, B Baum, TP Speed, AF Cowman, Regulation of Apicomplexan actin-based motility, Nature Reviews Microbiology 4, 621-628 (August). (* joint first authors) (Link)

K Belov, JE. Deakin, AT Papenfuss, ML Baker, SD Melman, HV Siddle, N Gouin, DL Goode, TJ Sargeant, MD Robinson, MJ Wakefield, S Mahony, Joseph GR Cross, PV Benos, PB Samollow, TP Speed, JAM Graves, RD Miller, Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial MHC, PLoS Biology, 4(3): e46. (Link)

AM Scott, FT Lee, R Jones, W Hopkins, D MacGregor, JS Cebon, A Hannah, G Chong, P U, A Papenfuss, A Rigopoulos, S Sturrock, R Murphy, V Wirth, C Murone, FE Smyth, S Knight, S Welt, G Ritter, E Richards, EC Nice, AW Burgess, LJ Old, A Phase I Trial of Humanized Monoclonal Antibody A33 in Patients with Colorectal Carcinoma: Biodistribution, Pharmacokinetics, and Quantitative Tumor Uptake, Clinical Cancer Research 2005;11 4810-4817 (Link)

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