Research Activities:
Melanie
Bahlo is a Fellow in the Bioinformatics Division at the
WEHI. She gained her PhD at Monash University
in 1997 for
her thesis “Gene Conversion and the Coalescent” under the PhD
supervision of
Professor Bob Griffiths. She then completed a two year stint as a
postdoc
working on migration models in the coalescent. In 1999 she moved to
join
Professor Terry Speed’s bioinformatics group at the WEHI. .
Her current
research interests are in linkage and association mapping of
quantitative and
qualitative traits in humans and mice. She was awarded an NHMRC R.D. Wright Fellowship in 2006. Within WEHI she collaborates
with Genetics
group on the Tasmanian Multiple Sclerosis (MS0 project and the Division
of
Cancer and Hematology on ENU screens in mice. Outside
of the WEHI some of her collaborations are with Associate Professor Henrik Dahl, Murdoch Children's Research Institute on deafness, Professor Sam Berkovic at the
and with Epilepsy Research Centre on epilepsy.
She also
works closely with the Melbourne
division of the AGRF and their clients.
Melanie's research interests include the detection and mapping of ENU
mouse mutants
either through qualitative or quantitative traits, mapping of
susceptibility
haplotypes in MS in a Tasmanian population, the mapping of various
Mendelian
traits and association mapping of malaria susceptibility loci in PNG.
She is
always interested in new research projects involving interesting
pedigrees and
traits and offers PhD and Honours projects in these areas. Please contact her for more details after reading the information on PhD and Honours study in Bioinformatics.
List of
selected publications
- Bahlo, M.,
Xing, L., Wilkinson, C. "HumanMSD and MouseMSD: Generating Genetic Maps
for Human and Murine Microsatellite Markers." Bioinformatics
(2004): Accepted 17th of June 2004.
- Banerjee, P.; Bahlo, M.;
Schwartz,
J. R.; Loots, G. G.; Houston, K. A.; Dubchak, I.; Speed,
T. P.; and Rubin, E. M. "SNPs in putative regulatory regions identified
by
human mouse comparative sequencing and transcription factor binding
site
data." Mamm Genome 13 (Oct 2002): 554-557.
- Carpinelli,
M. R.; Wicks, I. P.; Sims, N. A.; O'Donnell, K.; Hanzinikolas, K.;
Burt, R.;
Foote, S. J.; Bahlo, M.;
Alexander, W. S.; and Hilton, D. J. "An
ethyl-nitrosourea-induced point mutation in phex causes exon skipping,
x-linked
hypophosphatemia, and rickets." Am J Pathol 161 (Nov 2002):
1925-1933.
- Rubio, J. P.; Bahlo, M.;
Butzkueven, H.; van Der Mei, I. A.; Sale, M. M.; Dickinson, J. L.;
Groom, P.; Johnson, L. J.; Simmons, R. D.; Tait, B.; Varney, M.;
Taylor, B.;
Dwyer, T.; Williamson, R.; Gough, N. M.; Kilpatrick, T. J.; Speed, T.
P.; and
Foote, S. J. "Genetic dissection of the human leukocyte antigen region
by
use of haplotypes of tasmanians with multiple sclerosis." Am J Hum
Genet 70 (May 2002): 1125-1137.
- Ewen, K. R.; Bahlo, M.;
Treloar,
S. A.; Levinson, D. F.; Mowry, B.; Barlow, J. W.; and
Foote, S. J. "Identification and analysis of error types in
high-throughput genotyping." American Journal of Human Genetics
67
(2000): 727-736.
- Bahlo, M.
"The expected number of alleles in a gene conversion model with
mutation." Theoretical Population Biology 56 (1999): 265-277.
- Bahlo, M.,
and Griffiths, R. C. "Inference from gene trees in a subdivided
population." Theoretical Population Biology 57 (2000): 79-95.
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