Bioinformatics Seminar
Time: 11AM
Venue: Zoom Webinar
12 October 2021
This is a PhD Completion SeminarUnderstanding Information Flow Using Network-based Analysis of Phosphoproteomic Data
Hannah HuckstepWEHI Bioinformatics
Protein phosphorylation is one of the best known post-translational mechanisms playing a key role in the regulation of almost all cellular processes. Currently is it estimated that up to a third of the human proteome is phosphorylated at any one time, and over 100,000 distinct human phosphosites have been recorded to date. However, data saturation is occurring in part due to a lack of downstream phsophoproteomics specific analysis tools, adding to the the bottleneck of assigning biologically relevant functionality to phosphosites. In this talk I will present the research I have undertaken throughout my thesis that leverages literature derived knowledge bases to give mechanistic insight into these phosphorylation events. I will focus on my latest research involving the development of a novel network analysis method capable of highlighting concentrated regions of the network involved in phosphoproteomic signalling, as well as a complete analysis of a novel phosphoproteomic dataset featuring the software tool developed throughout my PhD