Bioinformatics Seminar
Time:
Venue: Na
3 March 2020
NaHigh-throughput multiplexed tandem repeat genotyping using targeted long-read sequencing
Lachlan CoinThe University of Melbourne
Tandem repeats (TRs) are highly prone to variation in copy numbers due to their repetitive and unstable nature ; which makes them a major source of genomic variation between individuals. However ; population variation of TRs have not been widely explored due to the limitations of existing tools ; which are either low-throughput or restricted to a small subset of TRs.
In this talk I will describe our work in targeted sequencing of tandem repeats using both SureSelect capture ; as well as Cas9 based approaches.
I will describe bioinformatic approaches for genotyping tandem repeats using both short and long read data.;;;;