Bioinformatics Seminar
Time:
Venue: Na
8 October 2019
NaApplication of Identity by Descent (IBD) Analyses to the Control and Elimination of Malaria
Alyssa BarryDeakin University
The rapidly growing interest in genomics for the surveillance of malaria in recent years ; has necessitated the development of robust analytical methods to interpret parasite genetic data. Multiple groups have simultaneously developed Identity by Descent (IBD) approaches to identify related infections and to map population connectivity. IsoRelate ; developed at WEHI by Lyndal Henden and Melanie Bahlo ; uses a MCMC algorithm to quantify IBD amongst haploid recombining genomes (PLoS Genetics 2018). IsoRelatehas unique features including the ability to output visually appealing and easy to interpret relatedness networks ; and to identify genomic regions under selection. In this presentation ; I will show how we are applying IsoRelateto parasite genetic data (both genotyping and whole genome sequence) to infer migration patterns ; the impact of control on parasite population structure ; and to determine the origins of mutations associated with antimalarial drug (artemisinin) resistance.IsoRelate has enormous utility in the genomic surveillance of malaria and other haploid pathogens. IBD analyses can be incorporated into genomic surveillance activities to monitor emerging threats such as drug resistance ; and to provide essential data on the spread of infections so that control resources can be targeted to areas where they can have the greatest impact.;Actual Venue : Davis Auditorium;