Bioinformatics Seminars

Bioinformatics Seminar

Time:
Venue: Na

1 October 2019

Na

Bioinformatics for accelerated antibody drug discovery

Monther Alhamdoosh
CSL

During the past two decades ; a large number of antibody (Ab) libraries have been constructed to meet the needs of drug discovery and diagnostic processes. CSL has developed its own proprietary antibody libraries in the past few years in order to accelerate drug candidates discovery and stay competitive in the market. The advent of DNA sequencing technologies has enabled scientists to rigorously assess several aspects of the Ab libraries at different stages of the construction process. Bioinformatics has been instrumental into this process by enabling scientists to validate the quality of their libraries while they are under construction. In this talk ; I will explain how antibody libraries are constructed and used in practice to screen for new drugs. I will also present our in-house bioinformatics workflow ; named AbSeq ; and how we used advanced machine learning in order to accelerate the discovery of new drug candidates.;;;;


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