Bioinformatics Seminar
Time:
Venue: Na
18 June 2019
NaUntangling mixed infections in Mycobacterium tuberculosis whole genome sequencing
Jacob MunroWEHI Population Health & Immunity
Mixed M. tuberculosis infections arise from multiple transmission events to a single host and have been observed in populations with higher incidence rates of TB. Different strains of M. tuberculosis possess different antibiotic resistance profiles and pathogenicity ; and as such ; accurate detection of mixed infections can impact treatment decisions and clinical outcomes. Here we propose a novel method for detection of mixed infections from WGS data ; and provide benchmarking against existing methods.