Bioinformatics Seminars

Bioinformatics Seminar

Time: 10:45am Tuesdays.
Level 7 Seminar Room 2, WEHI1

9 October 2018

Actual location : Davis Auditorium

Exploring post-transcriptional regulation in the context of a cell differentiation process (EMT)

Katherine Pillman
University of South Australia

We have found that a microRNA that acts as a master regulator of epithelial to mesenchymal transition impacts not only directly on its mRNA targets, but indirectly affects alternative splicing and transcription. I will discuss the bioinformatic approaches we have been using to understand the extent and outcomes of these regulatory aspects. This includes our use of Exon-Intron Split Analysis (EISA) as a tool to distinguish transcriptional from post-transcriptional events.

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