Bioinformatics Seminars

Bioinformatics Seminar

Time: 10:45am Tuesdays.
Level 7 Seminar Room 2, WEHI1

8 May 2018

Designing a biological database for deep mutational scanning

Alan Rubin
WEHI Bioinformatics

Deep mutational scanning is a widely-used method for multiplex measurement of the functional consequences of protein variants, greatly enhancing our ability to probe sequence-function relationships. Deep mutational scanning has many applications, including understanding protein evolution, exploring protein structure, improving protein function, and comprehensive interpretation of variants found in disease-related proteins. Despite its growing popularity, there is no central repository for deep mutational scanning datasets and much of the raw and processed data is either unavailable or in non-machine readable formats. To help experimenters and data modellers overcome these challenges, we have developed MAVEDB, a central repository for processed data, associated metadata, and linked raw data using a standardized and searchable format.

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