Bioinformatics Seminars

Bioinformatics Seminar

Time: 10:45am Tuesdays.
Level 7 Seminar Room 2, WEHI1

10 April 2018

Actual location : Seminar Room 1

A pan cancer hypoxic gene signature - highlighting temporal changes that lead to poor patient survival.

Kristy Horan
WEHI Computational Biology

An insufficient oxygen supply is a common feature of many solid tumours, and the consequential hypoxic microenvironment has been linked to poor patient outcomes as well as and chemo- and radio-therapy resistance. Tumour hypoxia can induce an epithelial-mesenchymal transition and angiogenesis - these changes are linked to a more aggressive cancer progression and perhaps also facilitate metastatic dissemination. A number of high-throughput studies have attempted to develop hypoxic transcriptomic signatures in specific cell types, however, many of these have been restricted in their selection of cell or tissue types and the duration of hypoxia investigated. We have used novel gene-set scoring technique to analyse public data and derive a pan cancer hypoxia signature which captures both moderate and chronic hypoxia, and appears to be a more accurate classifier of hypoxia than current signatures. Our pan-cancer signature has prognostic abilities when predicting survival across multiple cancer types, and it reveals a temporally-regulated network of genes that may impact on disease progression, and has the potential to identify novel targets for combination therapies.

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