Bioinformatics Seminars

Bioinformatics Seminar

Time: 10:45am Tuesdays.
Venue:
Level 7 Seminar Room 2, WEHI1

27 March 2018

Investigation of the tumor microenvironment with ARMET: a tool for differential tissue composition analyses

Stefano Mangiola
WEHI Bioinformatics

The properties of the tissue microenvironment are key for many pathological conditions such as cancer. For cancer, the presence and behavior of specific benign cell types within the tumoral mass have been shown to be key for its progression and response to treatments. The computational inference of changes in tissue composition across disease conditions using tissue gene expression is a high-throughput approach that enables large epidemiological investigations of the tumor microenvironment, using novel and publicly available data. Here, I will present ARMET: a tool that allows robust differential tissue composition analyses. Finally, I will close with recent results from an experimental approach to the study of the prostate tumor microenvironment, that includes the transcriptomic analysis of purified key cell types from cancer tissue.


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