Bioinformatics Seminars

Bioinformatics Seminar

Time: 10:45am Tuesdays.
Level 7 Seminar Room 2, WEHI1

5 December 2017

Using ATAC-seq to study chromatin accessibility and gene regulation

Yang Liao
WEHI Bioinformatics

Changes on chromatin accessibility take an important part in the regulation of gene expression. ATAC-seq is proven to be useful in studying chromatin accessibility, and many pipelines have been used in sequencing read analysis. By combining our short read aligner and read quantifier, the Homer peak caller and the Limma/edgeR packages, our pipeline provides a fast yet systematic view to the changes on chromatin accessibility between sample, therefore helping biologists to understand the roles of the key transcription factors in gene expression regulation. In this talk, I will briefly introduce the ATAC-seq technologies and its use in analyses, then present our pipeline for studying the functions of key transcription factors in two real cases.

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