Bioinformatics Seminars

Bioinformatics Seminar

Time: 10:45am Tuesdays.
Level 7 Seminar Room 2, WEHI1

20 June 2017

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Intraclonal heterogeneity during progression to malignancy in multiple myeloma

Lynn Fink
Diamantina Institute, University of Queensland

Multiple Myeloma (MM) is a largely incurable haematological malignancy characterised by the clonal proliferation of malignant plasma cells within the bone marrow. We performed deep exome sequencing of 10 paired longitudinal MM patient samples in order to characterise the molecular events involved in the progression from the asymptomatic condition, Monoclonal Gammopathy of Undetermined Significance (MGUS), to symptomatic MM. We confirm previous studies reporting that heterogeneity is a common feature in presenting MM patients and we provide a detailed description of the mutations, genetic landscape, and molecular pathways associated with disease progression as well as a potential novel driver of myelomagenesis.

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