Bioinformatics Seminar
Time:
Venue: Na
9 May 2017
NaUNSW
Jason WongJason Wong Lab / Lowy Cancer Research Center
Uncovering mutational and DNA repair processes in the search for cis-regulatory mutations in cancer genomes;Mutations that directly alter protein function have long been associated with cancer. Yet ; regions that code for proteins make up less than 2% of the human genome. In recent years ; it has become feasible to examine the cancer causing role of mutations within the remaining 98% of the non-coding genome. I will present our group's efforts in the search for cis-regulatory mutations - somatic mutations that cause the dysregulation of gene expression by altering the sequence of gene regulatory elements in the non-coding genome. Significantly ; I will show how this led us to make an unexpected discovery of a novel mechanism involving transcription initiation and nucleotide excision repair which we have found to govern the frequency of somatic mutations at gene promoters (Perera et al. Nature 2016). Finally ; I will present our recent work on the impact of this mechanism at CTCF binding sites and its implications in cancer development.;Visit the information of the lab;;