Bioinformatics Seminar
Time:
Venue: Na
21 March 2017
NaPhenotypic Associations in Single T-cell Pedigrees: The Problem of Statistical Inference on Tree-Structured Data
Sarah Russell and Damian Hicks (joint)PeterMac and Swinburne University of Technology
The process by which T cells differentiate to form effector and memory cells continues to be an open question. To address this ; time-lapse fluorescence microscopy has been used to track post-activation naive T cells and their progeny ; recording ancestral relationships over many generations and phenotypic characteristics of individual cells. Building a statistical model to describe these pedigrees ; one that is general enough to identify associations between and within generations ; has required the development of a new framework for quantifying tree-structured information. The model reveals how the network of statistical relationships between family members of T cells compares to their network of familial relationships and estimates the proportion of variation attributable to each division. More generally ; by formalising the invariance properties of the binary tree structure ; the natural groupings of variables that compactly describe associations on any binary tree have been identified.;Davis Auditorium;