Bioinformatics Seminar
Time:
Venue: Na
28 June 2016
NaCharacterising transcriptional and signalling networks: integration and computation
Pengyi YangThe University of Sydney
Transcriptional and signalling circuitry controls various aspects of basic cellular processes including homeostasis ; proliferation ; and cell fate decisions ; with defects in mechanisms underlying these processes associated with a wide range of diseases. In this talk ; I will present integrative and computational approaches applied to characterise transcriptional and signalling networks. Specifically ; I will first describe an integrative analysis of a ubiquitous transcription factor NF-Y ; computationally revealing its role in embryonic stem cell (ESC) identity maintenance. This part of the talk will show case the power of data integration in characterising novel functions of transcription factors and their roles in regulating transcription networks. Secondly ; I will describe two methodological development studies for characterising cell signalling using mass spectrometry (MS)-based phosphoproteomics data ; show case how we can computationally identify key kinases and predict their substrates involved in the signalling cascades. Together these studies exemplify how data integration and computation fit into the grand picture of systems biology.