Bioinformatics Seminar

Time:
Venue: Na

31 May 2016

Nature

Quin Wills
University of Oxford

Nietzsche and Nurture: single-cell sequencing ; imaging and culture of gene edited macrophages to study inflammation;Technical improvements in single-cell perturbation ; live-cell imaging and single-cell sequencing are enabling the detailed dissection of heterogeneous inflammatory cell states. Combining all three modalities with the new Polaris lab-on-chip platform ; we are performing temporal studies of CRISPR-edited macrophage responses to inflammatory perturbation and HIV infection. While macrophages have poorly understood predetermined inflammatory phenotypes (their "nature") ; they are also highly plastic to microenvironmental cues ("nurture"). I'll discuss surprising results around a third axis (which I call the "Nietzsche effect") that can now be studied thanks to single-cell approaches.;;;

The Walter and Eliza Hall Institute of Medical Research