Bioinformatics Seminars

Bioinformatics Seminar

Time: 11:00am Tuesdays.
Zoom Webinar

8 October 2013

Construction and Analysis of Gene Regulatory Networks

Edgar Wingender
University Medical Center Göettingen (UMG), Germany

In a systems biological view, gene regulatory networks comprising transcriptional and post-transcriptional events may provide a suitable basis to study cellular processes such as cell proliferation, cell differentiation, apoptosis, or tumorigenesis. Using two independent criteria (predicted transcription factor affinity to potential genomic binding sites and multi-genome conservation of such sites), we have constructed the core of a transcriptional network for human cells. This network was expanded (a) by paralogous TF-target gene relations, based on a comprehensive transcription factor classification, and (b) by predicted and known microRNA-target gene relations. From the resulting gene regulatory reference network, a number of tissue-specific subnetworks could be extracted. They revealed structural particularities that seem to be characteristic for the different tissues. The concepts developed so far proved particularly useful when applied to the networks regulating cardiomyocyte differentiation from human induced pluripotent stem cells.

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