Current Bioinformatics Seminar
| 2006-02-28 Sam Wormald WEHI Making sense of public ChIP-on-chip data for IFNg/STAT1 Signal transducer and activator of transcription-1 (STAT1) is a key mediator of the cellular response to interferon-gamma (IFNg), a potent inflammatory cytokine. Recently, a wealth of genomic information has been generated for the IFNg/STAT1 pathway, including tiling array experiments for the transcriptional response to IFNg, and ChIP-on-chip experiments for the binding of STAT1 to the genome. I will present a critical survey of these experiments, and outline some preliminary approaches to analysing ChIP-on-chip data in combination with motif and expression information. |
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