Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance 1 M19114 GO_CELL_ADHESION_MOLECULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MOLECULE_BINDING.html Interacting selectively and non-covalently with a cell adhesion molecule. 97/272 Gene Ontology MF GO:0050839 1.3536093982022e-19 1.38368960705114e-17 5 76.969696969697 18 4.10184666121879e-21 5 1.96800442158083 2.03964509364614 1 53.5655507510444 2 M18158 GO_EXTRACELLULAR_MATRIX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_BINDING.html Interacting selectively and non-covalently with a component of the extracellular matrix. 43/88 Gene Ontology MF GO:0050840 2.47061493581505e-18 2.06633249177259e-16 5 49.2424242424242 21 7.48671192671226e-20 2 2.12774446108895 2.19458266326432 1 43.9506093903704 3 M18873 GO_PEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 60/252 Gene Ontology MF GO:0030414 2.18719393412114e-16 1.43729887099389e-14 40 37.0909090909091 22 6.62786040642767e-18 6 1.97580076497075 2.04651822706043 1 35.4289627441221 4 M18138 GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT.html The action of a molecule that contributes to the structural integrity of the extracellular matrix. 34/94 Gene Ontology MF GO:0005201 1.60292828716558e-22 2.94938804838468e-20 5 41.0909090909091 27 4.85735844595633e-24 1 2.32206302194646 2.33945619222896 1 59.9876285178389 5 M19199 GO_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 83/222 Gene Ontology MF GO:0019838 9.11560398518834e-12 3.99350269827299e-10 55 47.6363636363636 28 2.76230423794806e-13 4 1.84659740676224 1.96389989961056 1 22.8314867475243 6 M19121 GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 14/31 Gene Ontology MF GO:0008191 3.75160416096555e-10 1.27832438077345e-08 5 38.8181818181818 32 1.13684974595392e-11 1 2.15037883620424 2.23362126216804 1 25.0599507627121 7 M18565 GO_INTEGRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_BINDING.html Interacting selectively and non-covalently with an integrin. 64/163 Gene Ontology MF GO:0005178 6.14958383202163e-13 3.32801007379994e-11 15 74.3333333333333 36 1.86351025212831e-14 6 1.98305705246032 2.02378621118528 1 41.0863105269957 8 M18439 GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. 31/148 Gene Ontology MF GO:0004867 9.51230161837313e-19 8.75131748890328e-17 15 35.3030303030303 37 2.88251564193126e-20 7 2.15516008087625 2.1606741412043 1 44.5866143143905 9 M18092 GO_HEPARIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARIN_BINDING.html Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 76/236 Gene Ontology MF GO:0008201 3.65236704609516e-27 1.36559802508649e-24 10 61.1515151515151 38 1.10677789275611e-28 2 2.07957155424229 2.1727154740368 1 77.3662449682365 10 M18852 GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with platelet-derived growth factor. 11/23 Gene Ontology MF GO:0048407 3.26145769643797e-11 1.36388230941952e-09 50 71.2424242424242 39 9.88320514087741e-13 4 2.49875000872482 2.49875000872482 1 31.698969352548 11 M18114 GO_COLLAGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_BINDING.html Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 43/105 Gene Ontology MF GO:0005518 2.25806211214547e-20 2.59677142896729e-18 40 57.3939393939394 40 6.84261246104686e-22 3 2.26167198370017 2.29708353824881 1 55.5849274997079 12 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 35/85 Gene Ontology MF GO:0019199 3.07611866434471e-08 4.56456317935022e-07 10 59.6060606060606 41 9.32157184916224e-10 6 1.85578531087299 1.86024414506188 1 15.9109527178749 13 M18258 GO_GLYCOSAMINOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSAMINOGLYCAN_BINDING.html Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 95/306 Gene Ontology MF GO:0005539 1.68657836366383e-32 1.55165209457072e-29 5 49.7272727272727 41 5.11084352625406e-34 1 2.10720018471246 2.22087777198878 1 92.2067195683696 14 M17907 GO_PEPTIDASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_REGULATOR_ACTIVITY.html Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 84/301 Gene Ontology MF GO:0061134 1.16125106908491e-13 7.12233989038745e-12 25 79.4848484848485 47 3.51894263359082e-15 5 1.84448595507191 1.99925626935546 1 26.9550286077269 15 M18457 GO_GROWTH_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_ACTIVITY.html The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 57/168 Gene Ontology MF GO:0008083 3.83094290267085e-12 1.95803748358732e-10 25 102.363636363636 48 1.16089178869029e-13 16 1.97614899433092 1.94403148412552 1 28.4213988284019 16 M18984 GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON.html The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 53/144 Gene Ontology MF GO:0005200 3.45872256368302e-08 4.83703358783272e-07 20 255.30303030303 53 1.04809776414675e-09 2 1.91346017840722 1.63649175790525 0.333333333333333 18.1385091627229 17 M18617 GO_ENZYME_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_INHIBITOR_ACTIVITY.html Binds to and stops, prevents or reduces the activity of an enzyme. 147/494 Gene Ontology MF GO:0004857 8.18410518927381e-11 3.13724032255496e-09 110 76.030303030303 53 2.48003187563592e-12 2 1.72331921374208 1.83761127341302 1 19.1714440290274 18 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 26/67 Gene Ontology MF GO:0004714 5.26403794256279e-08 5.32506592777743e-07 10 61.5454545454545 55 1.59516305361053e-09 6 1.95204520166731 1.92428651119437 1 16.1468131967177 19 M18089 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 3/11 Gene Ontology MF GO:0016813 1.43074721482573e-06 4.47716815523697e-06 30 216.878787878788 56 4.76916068076053e-08 8 2.26834971271503 -2.37791855822632 -1 18.0647834166641 20 M18839 GO_GLYCOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_BINDING.html Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 64/193 Gene Ontology MF GO:0001948 7.93477243815003e-12 3.64999532154901e-10 35 142.909090909091 58 2.40447649641835e-13 3 1.87964910610778 2.09867552143888 1 25.5289346121008