Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M19106 GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). 15/59 Gene Ontology MF GO:0015370 8.01007365036907e-06 0.000320402946014763 10 34.5454545454545 9 7.28191164975987e-07 3 1.96543338974634 1.96543338974634 1 35.1787618644899 9 18 47 7 200 6 8 3 14 60 8 2 M18882 GO_HYALURONIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONIC_ACID_BINDING.html Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. 5/24 Gene Ontology MF GO:0005540 3.75599513612407e-05 0.00119155707766694 10 123.181818181818 14 3.75605862138184e-06 5 1.96015293275319 1.96015293275319 1 29.3570128586577 25 221 838 10 162 14 10 5 11 54 5 3 M18672 GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). 12/36 Gene Ontology MF GO:0005343 7.00210850256154e-07 4.29462654823774e-05 10 64.0909090909091 18 6.36555521016112e-08 1 1.96543338974634 1.96543338974634 1 43.9653502880896 18 47 53 9 483 20 9 1 12 47 6 4 M17907 GO_PEPTIDASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_REGULATOR_ACTIVITY.html Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 84/301 Gene Ontology MF GO:0061134 1.83690642857586e-05 0.000625908857144369 25 26.9090909090909 21 1.66992887831141e-06 5 1.37013824557079 1.41454086114192 1 22.4827385122832 21 5 21 6 76 28 15 10 76 22 16 5 M18873 GO_PEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 60/252 Gene Ontology MF GO:0030414 2.59923943996794e-06 0.000119565014238525 20 32.4545454545455 22 2.36294773718443e-07 8 1.34290292944713 1.39790279807722 1 26.9809751535276 22 8 18 60 59 18 23 17 88 27 17 6 M18063 GO_ANION_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). 19/65 Gene Ontology MF GO:0015296 0.000476834256088789 0.00751419012196559 25 65.4545454545455 24 4.33579670793584e-05 11 1.89394786561772 1.89394786561772 1 20.6066890937133 24 61 52 13 399 63 17 11 19 37 24 7 M19026 GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY.html Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 5/26 Gene Ontology MF GO:0001637 4.15552804900417e-06 0.000182051705003992 5 130.090909090909 25 4.15553581981064e-07 2 1.70733862440616 1.70733862440616 1 32.7062121344578 38 360 872 11 39 24 3 2 2 55 25 8 M18914 GO_CXCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CXCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. 6/15 Gene Ontology MF GO:0045236 9.34200465593838e-05 0.00214866107086583 5 265.363636363636 27 9.34239740790562e-06 2 0.857185672850884 0.857185672850884 1 11.7137240462758 27 186 848 338 14 2 6 16 640 839 3 9 M17945 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). 8/29 Gene Ontology MF GO:0005104 4.94899109942448e-05 0.00135182301370903 20 108 28 4.94910131918724e-06 1 1.52259909511685 1.52259909511685 1 22.3763809199318 33 112 624 101 17 5 1 21 16 230 28 10 M19199 GO_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 83/222 Gene Ontology MF GO:0019838 0.000114287201782649 0.00250343394381041 15 31.2727272727273 28 1.03902853899315e-05 4 1.35610287433086 1.39988672775305 1 18.0705774034869 11 4 25 40 48 59 28 14 72 8 35 11 M19223 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. 38/152 Gene Ontology MF GO:0015081 5.14280494345828e-05 0.00135182301370903 20 80.6363636363636 28 4.67538651598809e-06 4 1.59130806196452 1.71962211606151 1 23.3861398441806 16 40 30 8 647 35 42 19 28 4 18 12 M18383 GO_RECEPTOR_AGONIST_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_AGONIST_ACTIVITY.html Interacts with receptors such that the proportion of receptors in the active form is increased. 8/18 Gene Ontology MF GO:0048018 1.60831512569362e-05 0.000569096121399282 5 135.545454545455 29 1.60832676586113e-06 1 1.70443849826295 1.78325605346822 1 28.3291007613487 124 23 729 1 1 29 49 467 1 1 66 13 M18333 GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. 15/39 Gene Ontology MF GO:0005520 0.000563520978258417 0.00849900491799579 20 53.1818181818182 30 5.12423066935968e-05 13 1.22928642455148 1.22928642455148 1 13.0381983724928 17 17 36 18 279 54 48 13 30 59 14 14 M19229 GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY.html Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. 7/21 Gene Ontology MF GO:0030296 0.000282496897142444 0.00499802202636631 15 140.181818181818 31 2.82532815592551e-05 9 1.28035774577906 1.28035774577906 1 15.092029299143 19 197 920 74 9 22 11 54 194 31 11 15 M17970 GO_COMPLEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_BINDING.html Interacting selectively and non-covalently with any component or product of the complement cascade. 7/27 Gene Ontology MF GO:0001848 5.13910358654593e-05 0.00135182301370903 5 82.8181818181818 33 5.13922243714978e-06 2 1.08077360331253 1.1099059725563 1 15.8832366655714 36 24 627 2 4 44 38 25 3 75 33 16 M19036 GO_CYTOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_ACTIVITY.html Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 27/95 Gene Ontology MF GO:0004896 0.000481888279560837 0.00751419012196559 35 43.7272727272727 33 4.38176240736922e-05 7 1.52461875981437 1.52461875981437 1 16.5882838112669 13 115 127 33 22 8 7 43 33 58 22 17 M18138 GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT.html The action of a molecule that contributes to the structural integrity of the extracellular matrix. 34/94 Gene Ontology MF GO:0005201 2.23608271505372e-08 1.8701782707722e-06 15 51.0909090909091 36 2.03280248889208e-09 1 1.5635534427564 1.5635534427564 1 45.8760700689472 1 114 14 84 163 26 20 36 51 13 40 18 M18565 GO_INTEGRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_BINDING.html Interacting selectively and non-covalently with an integrin. 64/163 Gene Ontology MF GO:0005178 2.93121669214001e-09 3.37089919596101e-07 10 87.9090909090909 36 2.66474245095044e-10 7 1.64958706464524 1.64958706464524 1 54.6880462812643 7 169 8 49 498 36 21 22 81 16 60 19 M18092 GO_HEPARIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARIN_BINDING.html Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 76/236 Gene Ontology MF GO:0008201 1.01433481218191e-11 1.86637605441472e-09 5 87.8181818181818 38 9.22122556533262e-13 2 1.3796353773972 1.45016382641443 1 61.6865463207363 2 86 5 96 338 30 32 38 234 30 75 20 M18360 GO_RECEPTOR_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. 18/40 Gene Ontology MF GO:0030546 9.90935991801365e-05 0.00222356368892014 5 339.545454545455 38 9.00891480813881e-06 3 1.61641365976408 1.66186273622852 1 21.9656087066506 779 16 38 3 5 758 891 525 8 7 705 21 M18852 GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with platelet-derived growth factor. 11/23 Gene Ontology MF GO:0048407 2.22981356054265e-06 0.000113968248649958 25 53.3636363636364 39 2.02710529143363e-07 4 1.66764792998669 1.66764792998669 1 33.6834484244493 4 108 23 64 58 23 16 39 191 18 43 22 M19073 GO_RECEPTOR_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_REGULATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. 24/55 Gene Ontology MF GO:0030545 0.000137630597160957 0.00281378109751291 5 192.909090909091 40 1.25126552725026e-05 4 1.63341223415934 1.67411956027892 1 21.3411801869445 341 14 40 4 27 637 428 322 18 5 286 23 M18258 GO_GLYCOSAMINOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSAMINOGLYCAN_BINDING.html Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 95/306 Gene Ontology MF GO:0005539 1.75467038750493e-13 5.38098918834846e-11 5 75.0909090909091 41 1.59515489773189e-14 3 1.45662400904688 1.51679886457165 1 76.6201587051089 3 84 3 85 250 41 36 24 226 11 63 24 M18114 GO_COLLAGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_BINDING.html Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 43/105 Gene Ontology MF GO:0005518 8.1218029644292e-10 1.06743696103927e-07 10 63.2727272727273 45 7.38345724311598e-11 6 1.58087510815947 1.58087510815947 1 56.4540649725306 6 88 7 94 81 39 24 41 208 63 45 25 M19121 GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 14/31 Gene Ontology MF GO:0008191 5.67456350664195e-05 0.00145016622947516 5 56 46 5.15882716237629e-06 2 1.35093669854757 1.35093669854757 1 19.6425592794987 8 46 54 114 86 4 2 26 200 56 20 26 M18158 GO_EXTRACELLULAR_MATRIX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_BINDING.html Interacting selectively and non-covalently with a component of the extracellular matrix. 43/88 Gene Ontology MF GO:0050840 9.33014379813489e-07 5.36483268392756e-05 15 76.0909090909091 48 8.48195250457034e-08 5 1.62786965432094 1.62786965432094 1 35.608545737858 5 155 15 62 237 7 13 48 203 36 56 27 M18192 GO_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASE_BINDING.html Interacting selectively and non-covalently with any protease or peptidase. 60/192 Gene Ontology MF GO:0002020 0.000478255168125811 0.00751419012196559 45 108.454545454545 49 4.34871970049126e-05 9 1.82923701665045 1.82923701665045 1 19.9026167278052 45 171 133 24 565 42 29 49 60 66 9 28 M18617 GO_ENZYME_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_INHIBITOR_ACTIVITY.html Binds to and stops, prevents or reduces the activity of an enzyme. 147/494 Gene Ontology MF GO:0004857 0.000589191884454304 0.00860407196345968 60 81.3636363636364 53 5.35772488880744e-05 2 1.37138813043912 1.42223818654158 1 14.5078907928474 59 2 29 50 184 265 74 53 106 32 41 29 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 26/67 Gene Ontology MF GO:0004714 0.0293392290987786 0.11200037664264 60 80.8181818181818 57 0.00270345110252148 13 1.64244294217558 1.64244294217558 1 7.99893479172615 32 13 72 21 241 144 57 118 56 57 78 30 M18935 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION.html Any protein binding that is involved in cell-cell adhesion. 6/15 Gene Ontology MF GO:0098632 0.000137066027248405 0.00281378109751291 5 143.363636363636 59 1.37074482175495e-05 3 1.22554810741938 -1.22554810741938 -1 16.0122731938417 89 219 856 59 30 3 25 6 92 194 4 31 M18439 GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. 31/148 Gene Ontology MF GO:0004867 2.00728673517923e-06 0.000108629635080288 65 49.5454545454545 61 1.82480778785102e-07 12 1.3685616455526 1.3685616455526 1 27.7885105286218 14 12 16 76 62 48 22 61 100 73 61 32 M18752 GO_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any chemokine receptor. 22/77 Gene Ontology MF GO:0042379 0.00136272788842879 0.0169420223966822 60 105.363636363636 64 0.000123961156770056 16 1.35565914634759 1.35565914634759 1 12.2981329830211 53 59 49 141 16 115 79 60 135 388 64 33 M18961 GO_CHEMOREPELLENT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOREPELLENT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. 19/41 Gene Ontology MF GO:0045499 0.0118447417256414 0.0681072649224379 30 106.909090909091 68 0.00108263621496536 30 1.29601695433188 1.29601695433188 1 7.74588662895891 30 60 61 112 301 152 31 183 139 39 68 34 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 35/85 Gene Ontology MF GO:0019199 0.010908571149087 0.0639228373067518 50 84.9090909090909 69 0.000996639922206892 11 1.50811869193233 1.53179215093363 1 9.22627789610461 50 11 50 20 69 233 98 162 74 28 139 35 M17949 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 14/38 Gene Ontology MF GO:0001106 2.378777417352e-05 0.000781598294272799 65 100.181818181818 73 2.16254830778967e-06 2 1.20323061682015 1.40839380365713 1 19.1493490419518 64 73 180 78 2 38 33 259 199 124 52 36 M18684 GO_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. 19/59 Gene Ontology MF GO:0008146 0.0159129995408727 0.0813331087644607 75 113.818181818182 74 0.00145720730791327 38 1.29181851715696 1.26177402314182 1 7.2107933630164 74 44 56 61 135 216 286 92 70 38 180 37 M17962 GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. 6/15 Gene Ontology MF GO:0034483 0.000323789344280818 0.00551641105071024 10 170.181818181818 76 3.2383653175044e-05 7 1.24641163481477 1.14859695860583 1 14.4182670800921 261 76 626 69 25 343 285 9 7 64 107 38 M18236 GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 6/14 Gene Ontology MF GO:0004185 0.00556380944008033 0.0409496374789913 55 137.909090909091 77 0.000557778891436243 24 1.59796482878087 1.59796482878087 1 11.3589980947525 56 53 694 53 77 167 27 80 189 24 97 39 M18649 GO_CARGO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARGO_RECEPTOR_ACTIVITY.html Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis. 31/78 Gene Ontology MF GO:0038024 4.77813269302836e-05 0.00135182301370903 80 110.727272727273 79 4.34385133765491e-06 10 1.64689748044487 1.64689748044487 1 24.2030916043311 10 105 22 97 320 79 47 77 267 74 120 40 M18980 GO_APOLIPOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOLIPOPROTEIN_BINDING.html Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex. 7/26 Gene Ontology MF GO:0034185 0.000131470874216731 0.00281286521579982 60 221.181818181818 82 1.31478652930277e-05 4 1.90919498657043 1.90919498657043 1 24.9457741673018 60 485 865 82 515 109 4 30 50 218 15 41 M17957 GO_SULFUR_COMPOUND_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BINDING.html Interacting selectively and non-covalently with a sulfur compound. 124/344 Gene Ontology MF GO:1901681 3.22545622993111e-11 4.94569955256104e-09 10 98.7272727272727 84 2.932232936344e-12 6 1.38395585325669 1.4602529066669 1 58.8794648486225 12 135 6 126 252 113 84 32 232 10 84 42 M19010 GO_FRIZZLED_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRIZZLED_BINDING.html Interacting selectively and non-covalently with the frizzled (fz) receptor. 17/44 Gene Ontology MF GO:0005109 0.00939072450149282 0.0579829969219691 70 159.909090909091 85 0.000857368191159428 30 1.57245504476898 1.66409842843252 1 9.96102340523144 130 119 66 34 392 85 30 678 66 70 89 43 M19159 GO_CYTOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_ACTIVITY.html Functions to control the survival, growth, differentiation and effector function of tissues and cells. 70/239 Gene Ontology MF GO:0005125 7.77838765410183e-08 5.1115118869812e-06 35 112.545454545455 89 7.07126175374265e-09 6 1.48689257814106 1.40801832193301 1 40.3010108215613 35 6 13 30 558 89 124 151 103 23 106 44 M19210 GO_HEXOSAMINIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSAMINIDASE_ACTIVITY.html Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. 9/18 Gene Ontology MF GO:0015929 1.31811301181103e-05 0.000505276654527562 95 210.454545454545 91 1.3181208302749e-06 4 2.1897291610845 2.1897291610845 1 36.9744079087794 93 561 917 63 324 174 75 4 6 91 7 45 M18468 GO_FIBRONECTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRONECTIN_BINDING.html Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. 22/46 Gene Ontology MF GO:0001968 0.00502763259823226 0.0391984914438447 50 165 99 0.000458105370830978 27 1.30514269064587 1.30514269064587 1 9.40438796330951 47 309 48 99 357 61 37 285 364 181 27 46 M18816 GO_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a growth factor receptor. 75/186 Gene Ontology MF GO:0070851 0.0207913614361415 0.0946672168148218 60 106.727272727273 99 0.00190822657983692 43 1.6386094923525 1.6386094923525 1 8.59314913922522 48 168 140 132 223 43 59 89 115 99 58 47 M18738 GO_TASTE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TASTE_RECEPTOR_ACTIVITY.html Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. 2/40 Gene Ontology MF GO:0008527 0.000175370419350939 0.00336126637089301 85 210.4 99.5 1.94871210725887e-05 7 1.29994081892301 1.29994081892301 1 16.4701129130394 82 432 804 NA 358 217 50 7 25 117 12 48 M18528 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the transforming growth factor beta receptor. 20/59 Gene Ontology MF GO:0005160 0.00564493226316079 0.0412169657310153 45 403.636363636364 100 0.000514497156138827 20 1.28806122322489 1.06088630802773 1 9.13742940146783 751 91 86 42 100 664 903 825 42 20 916 49 M18862 GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. 10/43 Gene Ontology MF GO:0005310 0.00109945016496701 0.0142463965037978 100 225.727272727273 100 1e-04 9 2.13629216850644 2.13629216850644 1 20.2033473917015 192 50 100 12 808 585 498 23 9 98 108 50 M18900 GO_PROTEIN_TYROSINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_BINDING.html Interacting selectively and non-covalently with protein tyrosine kinase. 39/84 Gene Ontology MF GO:1990782 0.00196027873720917 0.0212171345674405 20 156.727272727273 104 0.00017836614524792 13 1.40802345601483 1.40802345601483 1 12.0683733909917 20 104 320 173 417 19 26 82 224 326 13 51 M18680 GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. 59/148 Gene Ontology MF GO:0008194 0.012122501654268 0.0686876911906563 110 275.909090909091 106 0.00110816538984741 31 1.58969706419721 1.93267051298998 1 9.47111024948153 436 87 110 32 66 794 718 55 31 106 600 52 M19124 GO_EPHRIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ephrin receptor. 21/43 Gene Ontology MF GO:0046875 0.0144257323972153 0.0771076028004257 80 198.181818181818 107 0.00132010924284844 40 1.42507817668233 1.42507817668233 1 8.12376805973284 78 445 144 222 94 486 431 107 87 40 46 53 M18800 GO_SOLUTE_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). 42/113 Gene Ontology MF GO:0015294 0.0179730152441243 0.0870272317083914 145 173.818181818182 108 0.00164741348770494 39 1.65861853402329 1.89394786561772 1 9.00855698085213 145 39 90 43 271 607 219 64 59 108 267 54 M18390 GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. 12/19 Gene Ontology MF GO:0071617 0.0176594736657493 0.0864187009174964 110 144.090909090909 109 0.00161844005442823 41 1.02192717514728 -1.02192717514728 -1 5.56640797713133 109 217 290 106 137 68 41 154 108 300 55 55 M18143 GO_LYSOPHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPASE_ACTIVITY.html Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. 9/23 Gene Ontology MF GO:0004622 0.00469670761148144 0.0375736608918515 90 202.545454545455 110 0.000470666381788524 27 1.82051220676583 1.82051220676583 1 13.2894055399197 88 110 673 103 42 404 266 34 27 257 224 56 M19114 GO_CELL_ADHESION_MOLECULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MOLECULE_BINDING.html Interacting selectively and non-covalently with a cell adhesion molecule. 97/272 Gene Ontology MF GO:0050839 3.80114538604268e-08 2.69004135012251e-06 25 160.727272727273 111 3.45558677428965e-09 12 1.63873404781442 1.64958706464524 1 46.7567228166387 23 392 12 111 604 154 104 28 123 33 184 57 M18011 GO_DIACYLGLYCEROL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_KINASE_ACTIVITY.html Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. 5/11 Gene Ontology MF GO:0004143 0.00317146241826489 0.0286053473019971 160 178.090909090909 113 0.000317599770871137 27 0.995816582010741 -0.995816582010741 -1 7.87340203051505 158 27 637 113 31 90 40 407 193 167 96 58 M18847 GO_FUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 4/11 Gene Ontology MF GO:0008417 0.00259721827924189 0.0256583962096186 70 310.363636363636 114 0.000260025877601782 28 0.715858725339802 0.715858725339802 1 5.83305992465019 87 574 828 368 28 69 114 62 399 816 69 59 M18361 GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. 4/19 Gene Ontology MF GO:0015114 0.000933416804276543 0.0130112645444609 95 237.090909090909 116 9.33809106329965e-05 15 0.47679991343045 0.609276343343752 1 4.60538415186578 91 324 722 266 44 194 116 15 86 665 85 60 M18418 GO_BINDING_BRIDGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_BRIDGING.html The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. 86/250 Gene Ontology MF GO:0060090 0.0106380165312171 0.0636092142499135 120 134.818181818182 116 0.000971800654734473 51 1.49164226523606 1.49164226523606 1 9.14179977528629 66 284 116 165 239 220 112 52 116 51 62 61 M18725 GO_CCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a CCR chemokine receptor. 12/50 Gene Ontology MF GO:0048020 0.00145967163550772 0.0176697092719356 145 155.272727272727 117 0.000132785546306533 18 1.8541326198443 1.8541326198443 1 16.6466737808741 143 109 96 79 18 403 117 148 48 304 243 62 M19185 GO_CYTOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a cytokine receptor. 134/377 Gene Ontology MF GO:0005126 0.0322833961908555 0.117779902060934 70 157 117 0.00297882712119874 3 1.35957359523756 1.27585486635996 1 6.46914289070339 115 3 69 128 442 359 209 117 144 68 73 63 M18678 GO_CHEMOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_ACTIVITY.html The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 15/62 Gene Ontology MF GO:0008009 0.0284060023752119 0.110891789644148 55 208.272727272727 119 0.00261632232899321 55 0.857185672850884 0.857185672850884 1 4.19358653784411 55 203 68 422 98 170 56 119 235 763 102 64 M18309 GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. 8/15 Gene Ontology MF GO:0008239 0.0178760512396261 0.0870156991558518 150 189.272727272727 121 0.00180214996007168 22 1.57198936450653 1.57198936450653 1 8.53850607172883 147 97 710 157 74 319 121 108 22 80 247 65 M18836 GO_CARBONATE_DEHYDRATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBONATE_DEHYDRATASE_ACTIVITY.html Catalysis of the reaction: H2CO3 = CO2 + H2O. 8/14 Gene Ontology MF GO:0004089 0.0469545903305441 0.145448562640069 80 280.545454545455 122 0.00479772669288875 26 0.924440006815576 0.924440006815576 1 3.96475644576795 77 26 826 122 366 160 94 97 403 812 103 66 M18069 GO_MANNOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. 8/15 Gene Ontology MF GO:0015923 0.000155056638733376 0.00303515122627035 45 279.727272727273 123 1.55067458948511e-05 5 0.538228664593401 -0.538228664593401 -1 6.94149531553168 42 123 659 249 709 16 5 83 568 573 50 67 M18556 GO_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 24/72 Gene Ontology MF GO:0043394 7.24040348357072e-09 7.40130133876118e-07 15 110.545454545455 123 6.58218500672688e-10 9 1.38961153120483 1.45031310781471 1 43.6379659296439 15 116 9 137 173 159 102 123 217 12 153 68 M18028 GO_MIRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIRNA_BINDING.html Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. 7/25 Gene Ontology MF GO:0035198 0.00527038388618023 0.0400723402916183 90 308.181818181818 124 0.000528292539472375 31 1.35593454827845 1.35593454827845 1 9.70387066651082 86 701 644 629 116 124 81 37 731 210 31 69 M19095 GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a G-protein coupled receptor. 113/333 Gene Ontology MF GO:0001664 3.37917025251734e-08 2.59069719359663e-06 60 138.454545454545 129 3.07197300401903e-09 11 1.40734814162982 1.48488966664028 1 40.272577297775 57 189 11 105 253 173 55 294 162 95 129 70 M19157 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 13/56 Gene Ontology MF GO:0005245 0.0238345223306087 0.0994764046641727 75 260.363636363636 131 0.00219061165933972 68 1.37508621895887 1.37508621895887 1 7.05960739757848 73 870 131 546 474 175 68 72 240 121 94 71 M17861 GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. 16/32 Gene Ontology MF GO:0035250 0.0265314057387128 0.106333040262568 495 202 133 0.0024415341711523 19 2.37120295672305 -1.4264200637325 -1 11.8220072203704 494 19 112 86 95 215 429 297 29 133 313 72 M18457 GO_GROWTH_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_ACTIVITY.html The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 57/168 Gene Ontology MF GO:0008083 0.000243749249449369 0.0043970452841847 70 176.454545454545 134 2.2161478169533e-05 26 1.41018407103492 1.27908793553848 1 17.0242241020294 72 69 26 68 461 192 210 421 134 61 227 73 M18711 GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. 29/83 Gene Ontology MF GO:0035004 0.0186556989168512 0.0889287202254049 75 145.636363636364 137 0.0017105273311969 57 1.84083109373717 1.84083109373717 1 9.90970844472223 95 129 174 73 72 137 151 256 57 251 207 74 M17969 GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. 13/29 Gene Ontology MF GO:0016411 0.0174922635265784 0.0863990150566751 140 166.090909090909 138 0.00160299210590485 53 1.02192717514728 -1.02192717514728 -1 5.56692589632412 169 280 296 138 159 80 66 137 137 312 53 75 M19057 GO_NEUROPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_BINDING.html Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). 2/38 Gene Ontology MF GO:0042923 0.0329926216649286 0.11903220365386 140 304 139 0.00372074452639705 64 0.809767898063436 0.809767898063436 1 3.83399713712943 136 208 882 NA 140 112 64 138 356 877 127 76 M18918 GO_SIGNALING_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. 35/96 Gene Ontology MF GO:0035591 0.0120467469018945 0.0686876911906563 60 188.272727272727 140 0.00110120205259034 39 1.52694001982704 1.52694001982704 1 9.09721580866655 58 386 300 135 385 66 73 277 212 140 39 77 M18623 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other. 55/171 Gene Ontology MF GO:0005342 0.00313010200969255 0.0285118202863084 100 206.181818181818 142 0.000284960393388477 9 1.62841162664049 1.78717635804326 1 12.886864453667 98 9 43 35 554 624 191 201 120 142 251 78 M18948 GO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger to initiate a change in cell activity. 399/2329 Gene Ontology MF GO:0004872 2.28362373036649e-17 2.10093383193717e-14 5 132.181818181818 145 2.07602157306043e-18 1 1.42734479572756 1.48084087930213 1 100 26 232 1 145 314 178 149 101 172 2 134 79 M18747 GO_BETA_AMYLOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_BINDING.html Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. 14/39 Gene Ontology MF GO:0001540 0.00826424191061545 0.0527993233178209 135 148.909090909091 146 0.000754131869935777 34 1.7510196525423 1.7510196525423 1 11.456972879395 135 182 212 163 49 307 189 95 34 126 146 80 M18052 GO_VIRUS_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRUS_RECEPTOR_ACTIVITY.html Combining with a virus component and mediating entry of the virus into the cell. 44/110 Gene Ontology MF GO:0001618 0.00209790727443283 0.0224427289823046 40 181.454545454545 149 0.000190900954687039 37 1.50303631168883 1.64105995448902 1 12.6949733762983 40 544 37 339 150 252 141 58 219 67 149 81 M18291 GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS.html Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 18/40 Gene Ontology MF GO:0016877 0.014220702222309 0.0769223530568981 315 222.727272727273 149 0.00130122406918164 31 0.748518063101772 -0.748518063101772 -1 4.27099014552788 149 45 434 89 343 31 39 313 311 639 57 82 M17887 GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. 4/16 Gene Ontology MF GO:0004115 0.00304964250281122 0.0280567110258632 130 331.727272727273 150 0.000305383574780884 18 0.514974265481419 0.514974265481419 1 4.09381809783949 118 150 615 482 897 70 18 127 538 508 126 83 M18202 GO_AMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. 24/43 Gene Ontology MF GO:0004177 0.03635539790923 0.123967534382894 85 159.181818181818 150 0.00336095044420444 58 1.57198936450653 1.57198936450653 1 7.30080914538111 81 118 313 215 132 195 58 207 82 200 150 84 M18829 GO_ENZYME_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_REGULATOR_ACTIVITY.html Binds to and modulates the activity of an enzyme. 456/1178 Gene Ontology MF GO:0030234 0.00109945016496701 0.0142463965037978 30 233.909090909091 152 1e-04 5 1.35296027306779 1.4355311192297 1 12.7952190707166 257 30 67 5 123 838 310 221 152 29 541 85 M18845 GO_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. 45/104 Gene Ontology MF GO:0008238 0.0127320439412677 0.0705631350961824 60 192.727272727273 153 0.00116421187214977 56 1.47796954679659 1.62879946813931 1 8.7168917060309 213 56 205 160 57 502 153 130 85 119 440 86 M18598 GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY.html Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. 7/18 Gene Ontology MF GO:0005041 0.00046966087453846 0.00751419012196559 15 184.454545454545 154 4.6976016567575e-05 12 1.90919498657043 1.90919498657043 1 20.7725820883777 37 176 777 154 284 56 14 12 272 215 32 87 M18661 GO_MAP_KINASE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. 10/14 Gene Ontology MF GO:0033549 0.0108751554238355 0.0639228373067518 140 165.545454545455 155 0.000993571733637206 56 0.903622821473322 0.903622821473322 1 5.528129334093 140 146 215 161 56 86 195 111 284 272 155 88 M19182 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 21/89 Gene Ontology MF GO:0004869 0.0358092288457596 0.123967534382894 155 281.272727272727 155 0.00330961189885745 73 1.33344171706848 1.60371045402963 1 6.19291941120104 423 107 153 134 117 491 155 642 73 180 619 89 M18349 GO_SIGNALING_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_RECEPTOR_ACTIVITY.html Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 304/2031 Gene Ontology MF GO:0038023 1.75832285483148e-12 4.04414256611241e-10 30 130.363636363636 156 1.59847532257535e-13 4 1.43430099387452 1.47938234484939 1 69.0103521603247 29 188 4 156 152 234 184 124 171 14 178 90 M19080 GO_C_C_CHEMOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_C_CHEMOKINE_RECEPTOR_ACTIVITY.html Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. 2/13 Gene Ontology MF GO:0016493 0.00501684964560474 0.0391984914438447 105 229.8 156.5 0.000558674581443455 4 1.56054462896803 1.56054462896803 1 11.2447223323192 104 463 890 NA 193 149 173 40 4 118 164 91 M17964 GO_CARBOHYDRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BINDING.html Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. 102/328 Gene Ontology MF GO:0030246 0.00138460873091484 0.0169845337658887 230 252.727272727273 158 0.000125952811581593 32 1.40476476368069 1.45515781992054 1 12.7357729115434 230 83 32 95 75 731 526 307 145 158 398 92 M18474 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. 6/10 Gene Ontology MF GO:0016723 0.018609669368181 0.0889287202254049 85 300.636363636364 158 0.0018767375218428 43 0.420238326411515 -0.420238326411515 -1 2.26226029578551 84 358 749 455 158 74 43 144 428 697 117 93 M18891 GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. 24/52 Gene Ontology MF GO:0001102 4.47845872869669e-05 0.00132909097754869 700 410.545454545455 158 4.0714089978408e-06 3 1.50378242938551 1.7193104527397 1 22.156579756405 700 141 158 14 3 856 744 897 71 101 831 94 M17875 GO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_BINDING.html Interacting selectively and non-covalently with a SMAD signaling protein. 49/113 Gene Ontology MF GO:0046332 0.00812246969067256 0.0522564483595717 125 224.545454545455 159 0.000741146730275619 47 1.39167833273725 1.39206371989953 1 9.13778827847164 122 260 91 159 47 599 393 113 274 79 333 95 M18606 GO_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. 20/49 Gene Ontology MF GO:0008374 0.0236222402800974 0.0994764046641727 160 221.727272727273 160 0.00217088735001038 90 1.02192717514728 -1.02192717514728 -1 5.24651072558791 379 158 374 123 90 181 356 100 160 374 144 96 M18392 GO_ENZYME_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of an enzyme. 250/550 Gene Ontology MF GO:0008047 0.0328197409511618 0.118874652264051 325 301.636363636364 161 0.00302907491295591 1 1.37141753298858 1.44125377119001 1 6.49727291952502 324 1 136 51 108 911 516 340 161 45 725 97 M17911 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS.html Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). 24/77 Gene Ontology MF GO:0016782 0.0637823280905283 0.17486683789373 225 213.727272727273 164 0.00597365670823042 42 1.20527412203064 1.26177402314182 1 4.67531738773586 223 42 83 75 164 471 586 178 78 50 401 98 M18059 GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. 6/19 Gene Ontology MF GO:0015269 0.0124802097138279 0.0695866238589193 110 213.636363636364 164 0.00125508588122872 57 1.29994081892301 1.29994081892301 1 7.70719778680078 110 164 655 118 298 219 115 57 351 187 76 99 M18721 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY.html Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. 10/21 Gene Ontology MF GO:0030228 0.00163541132210851 0.0187028284809452 35 198.727272727273 165 0.00014878439114111 12 1.90919498657043 1.90919498657043 1 16.8996970163958 31 380 165 323 482 50 12 18 425 274 26 100 M18656 GO_ION_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. 16/51 Gene Ontology MF GO:0022839 0.0312423319718585 0.116402663015117 70 173.454545454545 166 0.00288136659585382 69 1.5361147374397 1.5361147374397 1 7.34935736885085 172 227 155 166 278 331 118 187 69 135 70 101 M19115 GO_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 707/2125 Gene Ontology MF GO:0005102 4.4652662493381e-05 0.00132909097754869 55 208.454545454545 168 4.46535597558762e-06 3 1.41587607427554 1.45989203349913 1 20.8613763132435 54 66 896 39 262 273 194 176 168 3 162 102 M17870 GO_SIGNAL_TRANSDUCER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCER_ACTIVITY.html Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 472/2441 Gene Ontology MF GO:0004871 1.68566566208402e-08 1.5508124091173e-06 10 173.818181818182 169 1.5324233409089e-09 9 1.40439576881526 1.47440148757879 1 41.7912571164811 67 127 10 148 217 417 277 205 169 9 266 103 M18124 GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY.html Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 4/26 Gene Ontology MF GO:0015464 0.0341821627783739 0.121419265467583 230 230.818181818182 169 0.00347196243671179 24 0.703015110000934 0.837738878644176 1 3.29750402780967 155 101 667 115 226 207 62 226 24 587 169 104 M18245 GO_SCAVENGER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAVENGER_RECEPTOR_ACTIVITY.html Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). 18/49 Gene Ontology MF GO:0005044 0.00282521946652946 0.0268194823689389 30 188 170 0.000257168556664506 28 1.55946497840302 1.55946497840302 1 12.5535141081586 28 264 42 150 368 230 140 170 312 77 287 105 M18302 GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. 15/37 Gene Ontology MF GO:0015175 0.0839184282471183 0.184260033382694 130 202.454545454545 171 0.00793650793650794 111 1.32018948758027 1.4836078808557 1 4.96741411997497 127 215 149 231 304 480 199 171 112 128 111 106 M19126 GO_OPSONIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPSONIN_BINDING.html Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. 5/21 Gene Ontology MF GO:0001846 0.0198830472111068 0.0934849879545127 710 362.909090909091 174 0.00200632212541376 36 1.04153308372933 -0.964244126337474 -1 5.4910950458734 706 134 900 36 85 460 157 722 52 174 566 107 M19008 GO_PEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 21/145 Gene Ontology MF GO:0001653 0.0644701616966633 0.175480913493876 45 190.363636363636 175 0.00604007028070481 43 1.70733862440616 1.70733862440616 1 6.6095359499877 43 396 93 278 335 133 76 175 155 179 231 108 M18861 GO_PHOSPHATIDIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_BINDING.html Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 6/19 Gene Ontology MF GO:0070300 0.0286872238427251 0.110891789644148 175 329.909090909091 176 0.00290644259315853 57 0.272987951853519 -0.272987951853519 -1 1.3355315597963 173 242 831 327 176 57 110 166 650 820 77 109 M19168 GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. 4/61 Gene Ontology MF GO:0008391 0.00737390137916501 0.0488056781930346 180 214.818181818182 176 0.000739848475451249 17 2.01369544572059 2.01369544572059 1 13.5279968943664 176 79 904 87 46 267 201 180 17 151 255 110 M19079 GO_SODIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_BINDING.html Interacting selectively and non-covalently with sodium ions (Na+). 8/30 Gene Ontology MF GO:0031402 0.00168767776606927 0.0189349212778504 215 251 177 0.000168896085303422 20 1.23478542520635 -1.08023697533246 -1 10.8961216275707 212 52 889 38 839 177 61 20 210 81 182 111 M18409 GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. 7/15 Gene Ontology MF GO:0048531 0.00261645269948875 0.0256583962096186 210 204.454545454545 178 0.000261953843517633 29 1.4264200637325 -1.4264200637325 -1 11.6229550799648 209 98 734 178 29 101 226 247 77 214 136 112 M18805 GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. 21/74 Gene Ontology MF GO:0008028 0.0211561343135951 0.0946672168148218 85 256.363636363636 178 0.00194203295778505 64 1.29795259620965 1.29795259620965 1 6.80668593681742 83 70 64 164 917 339 122 291 288 178 304 113 M18593 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 47/117 Gene Ontology MF GO:0001191 0.00015267665363091 0.00303515122627035 180 212.818181818182 179 1.38806591079993e-05 6 1.10597326277692 1.21032960265383 1 14.2636555921287 179 10 179 23 6 332 159 767 83 371 232 114 M18021 GO_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 39/105 Gene Ontology MF GO:0019210 0.0242011136625685 0.0994764046641727 140 228.272727272727 182 0.00222468288789426 73 1.30247026868399 1.28668928401077 1 6.68680160346421 182 140 265 264 645 330 109 73 140 162 201 115 M18813 GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS.html Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 33/63 Gene Ontology MF GO:0016879 0.0146790358441696 0.0771697884379201 40 325.454545454545 182 0.00134344576345152 33 0.389204480815532 -0.418874542401273 -1 2.2179920827381 39 640 304 697 138 33 182 69 605 802 71 116 M19038 GO_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. 165/602 Gene Ontology MF GO:0004175 0.0241346351215109 0.0994764046641727 85 374.181818181818 184 0.0022185034668956 82 1.35144836308486 1.44686169162144 1 6.93825210859703 897 152 84 381 91 184 824 737 183 82 501 117 M18613 GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 10/41 Gene Ontology MF GO:0015125 0.070241023881302 0.184260033382694 50 226.181818181818 186 0.00659902940166977 49 1.25240526293404 1.25240526293404 1 4.71236563852044 49 74 98 151 536 186 80 336 446 270 262 118 M18614 GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Increases the activity of a peptidase that is involved in the apoptotic process. 14/28 Gene Ontology MF GO:0016505 0.0301295990548854 0.114404890089332 190 216 187 0.00277730193072393 47 1.17181367894184 1.17181367894184 1 5.65152997706618 187 121 413 47 452 285 53 275 109 322 112 119 M18246 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. 6/14 Gene Ontology MF GO:0004861 0.029294195857095 0.11200037664264 130 254 189 0.00296876836034781 60 1.05077947290469 1.05077947290469 1 5.1174480319475 126 282 695 258 337 156 60 84 441 189 166 120 M18305 GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 4/20 Gene Ontology MF GO:0005328 0.00963683978798177 0.058714520562538 150 260 189 0.000967888755380556 51 1.62371583222612 1.62371583222612 1 10.2404594567037 177 345 709 172 189 380 148 51 307 146 236 121 M18365 GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. 6/13 Gene Ontology MF GO:0004859 0.00606029349311224 0.04343842839671 625 364.454545454545 190 0.000607688442844495 15 1.9366898762468 1.9366898762468 1 13.5126001689013 622 99 724 54 43 789 871 106 15 190 496 122 M18485 GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of modified amino acids from one side of a membrane to the other. 6/17 Gene Ontology MF GO:0072349 8.19453083000059e-05 0.00193306881117963 65 276 191 8.19483302219394e-06 2 1.34349992948527 1.34349992948527 1 18.6753826917641 63 344 751 286 906 51 34 8 400 191 2 123 M18278 GO_PEPTIDASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 25/51 Gene Ontology MF GO:0016504 0.00109945016496701 0.0142463965037978 165 218.272727272727 193 1e-04 15 1.47000107135756 1.47000107135756 1 13.9020975950944 163 251 332 15 499 458 51 186 46 207 193 124 M18624 GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY.html Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 5/14 Gene Ontology MF GO:0004467 0.0638644103611882 0.17486683789373 230 278.727272727273 194 0.00657776638450991 77 0.567844311749234 -0.591064356151949 -1 2.20269584083354 226 77 780 124 194 187 136 250 262 739 91 125 M18663 GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 68/213 Gene Ontology MF GO:0008514 0.0209801411245734 0.0946672168148218 195 276.090909090909 194 0.00192572085206552 7 1.63692490440573 1.76563934508099 1 8.58431487104453 194 7 63 66 555 745 281 469 122 127 408 126 M18978 GO_FATTY_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. 5/20 Gene Ontology MF GO:0015645 0.0638644103611882 0.17486683789373 230 298.181818181818 195 0.00657776638450991 78 0.567844311749234 -0.591064356151949 -1 2.20269584083354 227 78 864 125 195 188 137 258 263 853 92 127 M18132 GO_GTPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. 8/20 Gene Ontology MF GO:0005095 0.00295643776897851 0.0277543137495942 55 240 196 0.00029603783853599 19 1.3261771808088 -1.3261771808088 -1 10.5744931991448 51 196 668 291 701 37 87 29 325 236 19 128 M18823 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. 9/20 Gene Ontology MF GO:0016641 0.0815910603867166 0.184260033382694 200 284.636363636364 197 0.00847513379443655 62 1.93847904430292 1.93847904430292 1 7.29382285835488 62 111 825 200 486 191 135 197 556 259 109 129 M18211 GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY.html Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 117/1410 Gene Ontology MF GO:0004930 2.37563191697489e-06 0.0001150305980851 55 207.181818181818 198 2.15966771114888e-07 17 1.47803767622798 1.61140388188417 1 29.823159962981 52 488 17 361 218 321 212 133 175 104 198 130 M18388 GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 93/261 Gene Ontology MF GO:0005088 0.0839184282471183 0.184260033382694 205 289.818181818182 201 0.00793650793650794 22 1.47526426976399 1.70885312257134 1 5.55090663485242 201 34 104 22 467 546 418 561 98 136 601 131 M19034 GO_LAMININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMININ_BINDING.html Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. 20/43 Gene Ontology MF GO:0043236 0.0660661048766344 0.178767107313246 205 213.363636363636 201 0.00619433725763308 65 1.9083122944764 1.9083122944764 1 7.30879220304949 65 434 139 302 205 168 77 202 201 375 179 132 M18578 GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a negatively charged ion from one side of a membrane to the other. 98/337 Gene Ontology MF GO:0008509 0.0471190277163148 0.145468139258422 215 283.909090909091 204 0.0043781406987021 74 1.79798062199977 1.93208527549483 1 7.71067640611542 211 137 74 88 432 843 204 494 111 143 386 133 M18584 GO_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 18/36 Gene Ontology MF GO:0008378 0.0839184282471183 0.184260033382694 515 237.090909090909 204 0.00793650793650794 38 2.37120295672305 -1.4264200637325 -1 8.92201256367076 513 131 117 146 216 204 455 327 38 145 316 134 M18924 GO_SH3_SH2_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_SH2_ADAPTOR_ACTIVITY.html Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). 24/69 Gene Ontology MF GO:0005070 0.161385165508919 0.28120142475039 165 309 204 0.0158730158730159 102 1.52694001982704 1.52694001982704 1 4.30944512301447 161 395 221 107 864 255 165 753 204 102 172 135 M18060 GO_ACTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. 188/479 Gene Ontology MF GO:0003779 0.0162804990414776 0.0823449250770132 655 288.272727272727 205 0.00149111287290513 57 1.30422423360168 -1.31489616856209 -1 7.24416962849203 651 82 57 127 402 123 535 470 165 205 354 136 M17999 GO_ACID_AMINO_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_AMINO_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 13/27 Gene Ontology MF GO:0016881 0.00609082311214739 0.04343842839671 45 233.363636363636 206 0.000555250140679403 17 0.454612605508173 -0.482980324270456 -1 3.1719059614786 41 287 297 330 206 17 78 44 676 543 48 137 M18126 GO_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 93/233 Gene Ontology MF GO:0019207 0.0369986416233389 0.12443288690999 130 238.272727272727 206 0.00342144770056681 62 1.37030715595038 1.3754892870818 1 6.35271249159413 252 128 223 80 121 722 206 317 128 62 382 138 M17996 GO_RNA_POLYMERASE_III_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_III_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 9/21 Gene Ontology MF GO:0001056 0.0277025082992472 0.109854774290118 115 286.090909090909 207 0.00280540347321892 101 1.07643464219997 1.07643464219997 1 5.28871117115015 112 582 634 542 101 214 123 182 207 256 194 139 M18050 GO_ATPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the ATP hydrolysis activity of an ATPase. 12/24 Gene Ontology MF GO:0001671 0.0323894730667569 0.117779902060934 210 344.181818181818 208 0.00298876299035948 58 0.312510410146941 -0.35779721515743 -1 1.48699148000433 208 143 511 409 872 58 178 190 571 565 81 140 M18366 GO_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTININ_BINDING.html Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. 18/47 Gene Ontology MF GO:0042805 0.0205089271713748 0.0946672168148218 70 214.272727272727 208 0.00188205903318252 66 0.976907458631932 0.976907458631932 1 5.12307016068455 68 319 208 196 78 250 351 66 336 355 130 141 M18967 GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a sodium channel. 18/43 Gene Ontology MF GO:0017080 0.0223885903692105 0.0972338249470373 115 288.454545454545 208 0.00205633915630317 44 1.60817712248608 1.60817712248608 1 8.33785525347963 114 369 184 297 903 91 44 208 434 358 171 142 M18782 GO_NADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_BINDING.html Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. 25/65 Gene Ontology MF GO:0050661 0.0336134087886236 0.1201668279024 140 243.727272727273 209 0.00310347667342607 78 1.34336060295486 -1.34336060295486 -1 6.33204066539389 138 469 269 496 110 78 305 181 298 209 128 143 M18523 GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING.html Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. 6/17 Gene Ontology MF GO:0033612 0.0313303418784876 0.116402663015117 210 301.909090909091 210 0.00317810263685152 20 2.19676088401353 -2.19676088401353 -1 10.5101399581978 210 241 762 121 690 421 441 85 20 192 138 144 M18646 GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a carboxylic ester bond. 52/170 Gene Ontology MF GO:0052689 0.0839184282471183 0.184260033382694 210 315.727272727273 210 0.00793650793650794 62 1.02484661589878 -0.825930218182019 -1 3.85614152928127 565 103 206 129 255 142 522 887 62 392 210 145 M18012 GO_STEROID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BINDING.html Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. 39/140 Gene Ontology MF GO:0005496 0.00676808170133153 0.0463980650811938 55 301.181818181818 212 0.000617181195776002 45 1.38559854431451 1.48616062383464 1 9.46437791472922 427 57 45 98 212 554 268 833 55 52 712 146 M18123 GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. 20/60 Gene Ontology MF GO:0015179 0.0469534535353806 0.145448562640069 215 380.909090909091 213 0.00436241458543581 141 1.32018948758027 1.4836078808557 1 5.66205464597827 445 191 169 213 141 791 466 840 211 159 564 147 M17884 GO_NEUROTRANSMITTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BINDING.html Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 5/32 Gene Ontology MF GO:0042165 0.0765897756730953 0.184260033382694 220 300.454545454545 214 0.00793650793650794 37 0.51397685556881 0.692551127249515 1 1.93391615496717 216 126 613 109 889 327 95 214 37 506 173 148 M18179 GO_METALLOCARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOCARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 6/28 Gene Ontology MF GO:0004181 0.0318576636098703 0.117236202084323 185 279.909090909091 214 0.00323238065166729 65 1.68560957177209 1.68560957177209 1 8.03784189361277 185 513 681 310 260 423 150 86 192 65 214 149 M18399 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS.html Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). 114/262 Gene Ontology MF GO:0016746 0.00262161874315668 0.0256583962096186 145 274.545454545455 214 0.000238613454865243 9 1.14933443793958 -0.903365318821362 -1 9.36516727797899 144 515 539 561 67 9 214 177 300 473 21 150 M18916 GO_STEROID_HYDROXYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HYDROXYLASE_ACTIVITY.html Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. 7/72 Gene Ontology MF GO:0008395 0.0140054822222819 0.0762428618017713 110 278.090909090909 217 0.00140945423088793 59 2.01369544572059 2.01369544572059 1 11.5297476435787 108 357 849 280 488 132 307 59 117 217 145 151 M18549 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING.html Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. 8/27 Gene Ontology MF GO:0016922 0.0321004031835891 0.117658848322319 75 383.727272727273 218 0.00325737514280371 72 0.274094838101529 -0.278960835397933 -1 1.30482895518034 178 218 767 334 900 72 120 215 628 717 72 152 M19137 GO_AMMONIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_BINDING.html Interacting selectively and non-covalently with ammonium ions (NH4+). 16/79 Gene Ontology MF GO:0070405 0.0284310138573075 0.110891789644148 90 277.818181818182 218 0.00261865648165761 67 0.858982002181133 0.858982002181133 1 4.20237467206648 90 142 253 322 514 218 92 81 380 897 67 153 M18067 GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 27/145 Gene Ontology MF GO:0015103 0.0839184282471183 0.184260033382694 215 236.909090909091 220 0.00793650793650794 40 1.92910205009373 1.92910205009373 1 7.25854048777171 214 307 196 255 387 488 97 287 40 115 220 154 M18989 GO_ALPHA_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_ACTININ_BINDING.html Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. 12/31 Gene Ontology MF GO:0051393 0.0284772211832329 0.110891789644148 65 221.909090909091 220 0.00262296884292734 61 1.29994081892301 1.29994081892301 1 6.35966576719707 61 470 220 168 107 277 265 79 331 305 158 155 M18284 GO_STEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BINDING.html Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. 18/56 Gene Ontology MF GO:0032934 0.116086776895904 0.228261683703581 180 361 222 0.0111551676911695 78 1.26152223498324 -1.23475542503433 -1 4.14570600031928 604 181 178 179 222 596 691 627 215 78 400 156 M19143 GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. 12/30 Gene Ontology MF GO:0070001 0.00409839787142492 0.0339687030784769 590 381.909090909091 222 0.00037327752564731 34 1.48960342746458 -1.23435683890907 -1 11.2080666849306 587 194 222 212 34 770 612 870 93 113 494 157 M18163 GO_METALLOEXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOEXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 17/53 Gene Ontology MF GO:0008235 0.0444377920846555 0.140009481910558 270 216.636363636364 226 0.00412378396630186 99 1.68560957177209 1.68560957177209 1 7.37218752412244 99 327 252 341 134 268 119 210 269 138 226 158 M18787 GO_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 37/84 Gene Ontology MF GO:0019209 0.00752083327200224 0.0494226186445862 465 327.181818181818 227 0.000686060674806081 37 1.39182004964107 1.39182004964107 1 9.31134776342068 465 90 227 37 45 861 554 648 84 49 539 159 M19216 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. 8/14 Gene Ontology MF GO:0097153 0.0365433105657369 0.123967534382894 125 350.545454545455 228 0.00371585340919804 124 1.53150662091758 1.53150662091758 1 7.11279464800366 526 125 919 143 124 665 202 228 197 244 483 160 M19069 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC.html Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 8/18 Gene Ontology MF GO:0000983 0.00508300053019896 0.03929714695616 490 286 230 0.000509466469990526 37 1.25055290868511 -0.792904243146179 -1 9.00404081117884 489 96 888 83 37 292 534 147 107 243 230 161 M19227 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. 30/72 Gene Ontology MF GO:0043028 0.161385165508919 0.28120142475039 220 265.545454545455 230 0.0158730158730159 58 1.12156793107046 -0.792904243146179 -1 3.16537344727651 220 58 337 92 351 433 168 230 222 421 389 162 M18180 GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY.html Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. 10/21 Gene Ontology MF GO:0004029 0.00955970801120372 0.0586328758020495 500 263.818181818182 233 0.000872863863255798 36 0.965763951394085 -0.889162256391105 -1 6.09387457842453 497 49 161 41 53 416 566 583 36 267 233 163 M18839 GO_GLYCOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_BINDING.html Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 64/193 Gene Ontology MF GO:0001948 6.44614263768044e-06 0.000269565964848455 20 311.909090909091 233 5.86014684124889e-07 17 1.34890253209452 1.49117267097625 1 24.6620668128491 344 170 19 139 112 660 809 292 233 17 636 164 M18775 GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. 37/81 Gene Ontology MF GO:0033613 0.0316060463174936 0.116777359887928 530 370 235 0.00291540534178093 48 1.16613547394202 1.36416500127342 1 5.57089868725562 530 235 200 48 105 736 653 615 133 153 662 165 M18079 GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of metal ions from one side of a membrane to the other. 130/461 Gene Ontology MF GO:0046873 0.000396831157489539 0.00663790299800683 80 211.636363636364 237 3.60820686455787e-05 21 1.52039168531946 1.669687570465 1 16.9616772397387 79 294 27 187 559 281 259 237 130 21 254 166 M18466 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. 17/46 Gene Ontology MF GO:0043027 0.0589955710502433 0.167480482950892 175 309.363636363636 237 0.00551269744152521 125 1.12156793107046 -0.792904243146179 -1 4.4582962382081 359 173 237 175 157 497 185 607 125 350 538 167 M18801 GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-specific protease. 6/13 Gene Ontology MF GO:1990381 0.0577394136176347 0.1660008141507 220 364.818181818182 239 0.00592969074307417 105 0.238117597083269 -0.26458589220097 -1 0.951231573612256 219 220 820 239 576 200 261 105 433 798 142 168 M19165 GO_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_ACTIVITY.html Catalysis of the hydrolysis of a glycerophospholipid. 31/102 Gene Ontology MF GO:0004620 0.0785997443387219 0.184260033382694 135 295.545454545455 239 0.00741426400104891 88 1.82051220676583 1.82051220676583 1 6.84995464369501 132 619 148 533 473 290 88 213 94 422 239 169 M18013 GO_LEUCINE_ZIPPER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUCINE_ZIPPER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. 8/14 Gene Ontology MF GO:0043522 0.0172641229559445 0.0858540168619942 240 266.818181818182 240 0.00173997305232659 73 1.53334444632203 1.53334444632203 1 8.37444500831255 240 124 638 186 73 457 106 281 273 232 325 170 M18500 GO_MAP_KINASE_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_KINASE_ACTIVITY.html Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. 8/25 Gene Ontology MF GO:0004709 0.0922521991159774 0.196463016635878 75 316.727272727273 240 0.0096321796306115 71 1.21455215107271 1.21455215107271 1 4.3966777738281 71 646 754 458 502 99 147 140 313 240 114 171 M18303 GO_E_BOX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_E_BOX_BINDING.html Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. 12/40 Gene Ontology MF GO:0070888 0.045096752083171 0.141600723264564 160 287 242 0.00418623633758488 136 0.589081776363241 0.70893858882902 1 2.56160027365455 351 160 143 242 136 304 160 150 426 646 439 172 M18936 GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. 8/27 Gene Ontology MF GO:0043325 0.0373350709507474 0.12443288690999 115 344.727272727273 242 0.00379775747296043 93 1.99575500943266 1.99575500943266 1 9.2522744338389 111 162 857 142 841 407 372 93 432 242 133 173 M19009 GO_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. 52/156 Gene Ontology MF GO:0015293 0.0839184282471183 0.184260033382694 290 272 242 0.00793650793650794 38 1.56222160757482 1.89394786561772 1 5.87809687824209 286 38 94 44 347 831 451 242 68 83 508 174 M18527 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS.html Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). 120/288 Gene Ontology MF GO:0016757 0.0235506839000147 0.0994764046641727 760 384.090909090909 243 0.00216423952617261 89 1.45233484940393 1.63844636363022 1 7.45619708494462 758 165 243 149 89 389 881 333 96 227 895 175 M18733 GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING.html Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. 21/54 Gene Ontology MF GO:0043548 0.161385165508919 0.28120142475039 85 237.181818181818 244 0.0158730158730159 81 1.81020314995728 1.81020314995728 1 5.10889168816141 180 337 167 81 331 370 244 298 190 85 326 176 M18032 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 73/223 Gene Ontology MF GO:0001227 0.120060012162492 0.231935655570445 225 339.272727272727 245 0.0115600782506345 117 1.14939499393886 1.16217309581581 1 3.73639842729201 117 639 224 734 229 308 222 236 388 245 390 177 M18892 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. 24/49 Gene Ontology MF GO:0001105 0.00226399690566475 0.0233116103944839 790 368.090909090909 245 0.00020603001121206 24 0.8035527218967 -0.792904243146179 -1 6.71908180050147 787 43 245 26 24 425 861 125 142 829 542 178 M18824 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. 29/69 Gene Ontology MF GO:0030374 0.00760819092508836 0.0496420968161793 170 335.545454545455 246 0.000694057289953458 34 0.315200437469173 -0.323105938359131 -1 2.10560008051469 170 180 540 246 266 55 208 624 559 809 34 179 M19206 GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS.html Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. 7/13 Gene Ontology MF GO:0016801 0.00484727693921445 0.0384439205523905 250 384.727272727273 246 0.00048578827551355 35 1.43991841944783 1.43991841944783 1 10.437796095691 246 850 916 541 807 264 45 35 223 219 86 180 M18508 GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the rate of NTP hydrolysis by a NTPase. 173/380 Gene Ontology MF GO:0060589 0.0839184282471183 0.184260033382694 800 410.090909090909 247 0.00793650793650794 54 1.34929233812685 1.54768160055874 1 5.07691803296715 796 54 213 247 186 464 700 875 182 123 671 181 M18755 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. 54/216 Gene Ontology MF GO:0016705 0.0182081141628865 0.0877040053919142 255 296.272727272727 247 0.00166914378842148 60 1.68771337028521 1.71963375678033 1 9.13749785755975 251 247 60 240 234 617 497 394 159 139 421 182 M17982 GO_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 83/232 Gene Ontology MF GO:0004713 0.0839184282471183 0.184260033382694 175 275.909090909091 248 0.00793650793650794 153 1.64244294217558 1.64244294217558 1 6.17994188239993 175 153 181 171 288 524 248 505 180 293 317 183 M18262 GO_DAMAGED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DAMAGED_DNA_BINDING.html Interacting selectively and non-covalently with damaged DNA. 39/77 Gene Ontology MF GO:0003684 0.0660418795900204 0.178767107313246 50 385.818181818182 248 0.00619199380355318 46 0.55936453995665 -0.55936453995665 -1 2.14235322628314 46 696 521 612 248 125 193 239 750 631 183 184 M18869 GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY.html Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. 5/14 Gene Ontology MF GO:0045125 0.0765897756730953 0.184260033382694 105 309 248 0.00793650793650794 67 1.51430131785667 1.51430131785667 1 5.69778948094924 105 198 834 248 585 350 211 341 67 171 289 185 M17876 GO_SYNTAXIN_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_1_BINDING.html Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. 9/27 Gene Ontology MF GO:0017075 0.00282770629324682 0.0268194823689389 255 258.727272727273 250 0.000283131091566756 27 1.53334444632203 1.53334444632203 1 12.3432468202345 250 175 612 251 147 356 179 27 460 254 135 186 M17865 GO_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. 248/804 Gene Ontology MF GO:0008233 0.0215962189283108 0.0955217375675287 755 320.909090909091 251 0.00198283431528254 44 1.36704007640014 1.46127187807113 1 7.14166519234945 755 68 146 298 83 251 596 460 177 44 652 187 M18445 GO_PYRIDOXAL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDOXAL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. 25/53 Gene Ontology MF GO:0030170 0.143085576587824 0.266475162876109 170 298.909090909091 251 0.0139398569336401 166 0.81102437234372 -0.962450853144767 -1 2.38598116428029 202 250 239 335 251 166 425 299 548 403 170 188 M17886 GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 8/19 Gene Ontology MF GO:0070008 0.0207885672321943 0.0946672168148218 255 247 252 0.00209856409599045 25 1.59796482878087 1.59796482878087 1 8.38000155094181 331 25 614 52 103 633 254 158 261 34 252 189 M19220 GO_COENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BINDING.html Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 101/214 Gene Ontology MF GO:0050662 0.00455183242915619 0.0367340862703833 105 297.818181818182 253 0.000414661600726999 13 1.30128123270046 -1.30374486722373 -1 9.56453154819576 102 631 463 653 106 13 253 194 457 360 44 190 M19153 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the platelet-derived growth factor receptor. 9/18 Gene Ontology MF GO:0005161 0.023868456349707 0.0994764046641727 255 327.272727272727 254 0.00241287665412852 41 2.46711003640163 2.46711003640163 1 12.6659900850233 254 511 901 205 648 302 188 74 41 263 213 191 M18100 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS.html Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). 87/208 Gene Ontology MF GO:0016758 0.022834189207736 0.0986265449348223 915 360.272727272727 257 0.00209769921273611 53 1.49260391543528 1.72986854838162 1 7.69142512509262 914 178 257 119 87 298 717 376 53 183 781 192 M18285 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 232/695 Gene Ontology MF GO:0000981 0.0145771951149642 0.0771076028004257 395 242.545454545455 257 0.00133406265262364 55 1.28542000551168 1.38872432437297 1 7.32763586978716 107 391 55 363 130 288 257 233 339 111 394 193 M18701 GO_QUATERNARY_AMMONIUM_GROUP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_BINDING.html Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 10/56 Gene Ontology MF GO:0050997 0.108129172479104 0.217677983984192 115 328 258 0.0103491631349988 103 0.562285217214658 0.625525250068782 1 1.90720727865264 113 161 258 153 575 246 103 536 404 768 291 194 M18465 GO_MOLECULAR_FUNCTION_REGULATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLECULAR_FUNCTION_REGULATOR.html A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators. 622/1627 Gene Ontology MF GO:0098772 0.00228048362554734 0.0233116103944839 260 321.272727272727 259 0.000228282728372093 15 1.41239311918607 1.50577774062678 1 11.8100340255089 259 29 746 17 154 896 357 310 147 15 604 195 M18865 GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. 24/52 Gene Ontology MF GO:0008375 0.0506875587988939 0.151897570341962 100 364.909090909091 259 0.00471768229667165 5 1.51620281545252 -1.0514983455529 -1 6.35639097415999 693 172 259 19 293 798 882 96 5 100 697 196 M18207 GO_CALCIUM_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. 36/103 Gene Ontology MF GO:0048306 0.01147037736143 0.0665067615427107 230 340.909090909091 260 0.00104823835560867 51 1.73101063937183 -1.86637751467945 -1 10.4372793589853 454 635 51 437 227 163 406 804 227 86 260 197 M18586 GO_ALKALI_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALI_METAL_ION_BINDING.html Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. 14/43 Gene Ontology MF GO:0031420 0.0832022052310219 0.184260033382694 125 324.090909090909 260 0.00786602132726076 93 1.23478542520635 -1.08023697533246 -1 4.64606831227123 512 159 260 93 759 361 237 121 500 125 438 198 M18266 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a protein serine/threonine kinase. 15/25 Gene Ontology MF GO:0043539 0.00437964825912135 0.0356573132601031 175 281.909090909091 261 0.000398944674342053 23 0.363084398232927 -0.334856764357209 -1 2.69273211279725 171 267 441 261 521 49 86 122 527 633 23 199 M18878 GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. 73/254 Gene Ontology MF GO:0015291 0.0162899743087135 0.0823449250770132 285 292.272727272727 262 0.00149198721489877 36 1.517962129769 1.76563934508099 1 8.43135321677843 282 36 58 100 424 910 415 262 118 94 516 200 M17979 GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 121/397 Gene Ontology MF GO:0015077 0.0114941033535772 0.0665067615427107 105 275.727272727273 263 0.00105041802820569 26 1.42932458907497 1.55018285181761 1 8.6182370284733 263 55 101 46 551 701 383 375 101 26 431 201 M18561 GO_LRR_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LRR_DOMAIN_BINDING.html Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. 12/25 Gene Ontology MF GO:0030275 0.0503474009060609 0.151371270697961 200 244.090909090909 263 0.00468526668217691 70 1.53334444632203 1.53334444632203 1 6.44009316467162 196 206 382 276 181 320 70 169 321 301 263 202 M18777 GO_MICROTUBULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BINDING.html Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. 102/252 Gene Ontology MF GO:0008017 0.0145833944426892 0.0771076028004257 170 350.636363636364 264 0.00133463380341261 32 0.986339373070039 -0.808913397424817 -1 5.62270362786957 168 667 323 777 215 32 220 264 613 485 93 203 M17988 GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). 5/19 Gene Ontology MF GO:0005283 0.00417814688459707 0.034320492266333 170 281.454545454545 265 0.000418602334509471 33 1.62371583222612 1.62371583222612 1 12.1799393928608 167 419 630 260 265 347 271 33 309 166 229 204 M18212 GO_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_ACTIVITY.html Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 7/14 Gene Ontology MF GO:0004707 0.213465264533522 0.343818502708482 690 386.090909090909 265 0.0237258486982449 154 0.277258279576039 -0.335959629679328 -1 0.658499934736755 238 281 689 218 674 212 154 265 687 613 216 205 M18697 GO_CHEMOATTRACTANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOATTRACTANT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. 14/29 Gene Ontology MF GO:0042056 0.0211594542426217 0.0946672168148218 165 246.272727272727 265 0.00194234069436728 59 1.46584243959724 1.46584243959724 1 7.68712907672136 166 311 197 265 308 161 161 390 368 323 59 206 M18129 GO_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. 12/41 Gene Ontology MF GO:0004180 0.0124517850398045 0.0695866238589193 290 257.272727272727 266 0.00113843858860518 46 1.59796482878087 1.59796482878087 1 9.47414747956518 287 399 135 290 214 630 198 56 266 46 309 207 M18248 GO_METALLOENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 31/124 Gene Ontology MF GO:0004222 0.0839184282471183 0.184260033382694 645 462.363636363636 266 0.00793650793650794 63 1.32616604784015 1.58899488339618 1 4.98990183930141 644 200 256 209 792 883 731 156 63 266 886 208 M18575 GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 176/580 Gene Ontology MF GO:0022890 0.0374181982937055 0.12443288690999 270 309.909090909091 266 0.00346092692408017 35 1.40571680988789 1.54109637610644 1 6.51687083728776 266 177 78 203 479 676 432 438 143 35 482 209 M18464 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). 99/229 Gene Ontology MF GO:0016747 0.00725818646351962 0.0483879097567975 160 270.454545454545 267 0.000662022153261634 21 1.21800558206805 -0.912937137953248 -1 8.20584895887416 160 440 578 392 71 21 267 249 294 465 38 210 M19151 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS.html Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. 65/156 Gene Ontology MF GO:0016810 0.0107790869705894 0.0639228373067518 260 370.818181818182 268 0.000984751377655792 25 0.346329421774024 -0.372184857190102 -1 2.11875321519316 258 596 428 733 268 25 99 225 396 899 152 211 M18420 GO_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. 26/149 Gene Ontology MF GO:0004497 0.00218889922595793 0.0231469803204747 225 418.818181818182 269 0.00019918910171558 39 1.80282382826021 -1.59195221079983 -1 15.1031291216305 507 225 39 269 168 720 704 712 243 221 799 212 M18514 GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. 3/12 Gene Ontology MF GO:0008970 0.071144176729939 0.184260033382694 115 327.909090909091 272 0.00735300816575524 111 0.76275604133909 1.052909190563 1 2.86998577705629 300 368 758 192 412 272 111 112 187 706 189 213 M18730 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. 12/30 Gene Ontology MF GO:0016628 0.00374446356796615 0.0321953876871856 45 252.363636363636 272 0.000340986543719477 19 0.415593853607691 0.458222200270963 1 3.17657838960076 44 300 344 405 272 46 19 195 287 777 87 214 M18097 GO_SERINE_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 88/379 Gene Ontology MF GO:0017171 6.6169139290801e-05 0.00164528670669019 25 309 273 6.01555723054247e-06 24 1.41771045211756 1.45362296593558 1 20.215322748635 273 85 24 234 370 797 379 411 163 25 638 215 M18539 GO_CAMP_RESPONSE_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_RESPONSE_ELEMENT_BINDING.html Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. 8/16 Gene Ontology MF GO:0035497 0.0548939466802224 0.159313662289605 295 366.909090909091 273 0.00562990555291919 104 0.530468713592533 -0.530468713592533 -1 2.16763679301114 294 273 766 174 849 256 132 104 330 715 143 216 M18717 GO_AU_RICH_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AU_RICH_ELEMENT_BINDING.html Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. 10/26 Gene Ontology MF GO:0017091 0.0975528391223165 0.203511591819799 135 280.545454545455 273 0.00928797399608528 132 1.35593454827845 1.35593454827845 1 4.80215863458694 134 314 361 462 210 354 227 132 429 273 190 217 M18932 GO_NUCLEOSOMAL_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOMAL_DNA_BINDING.html Interacting selectively and non-covalently with the DNA portion of a nucleosome. 24/61 Gene Ontology MF GO:0031492 0.122960226482606 0.2352886341512 255 357.727272727273 274 0.0118566884950801 117 1.33403223803043 -1.33403223803043 -1 4.29401374676049 253 519 242 461 782 117 274 261 410 399 217 218 M18994 GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. 44/84 Gene Ontology MF GO:0050660 7.24737209336192e-05 0.00175462692786657 5 294.181818181818 274 6.58873713786949e-06 1 1.59195221079983 -1.59195221079983 -1 22.4719994438252 80 534 375 736 274 1 89 63 633 450 1 219 M18186 GO_PHOSPHATE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_BINDING.html Interacting selectively and non-covalently with phosphate. 8/18 Gene Ontology MF GO:0042301 0.00381885525351554 0.0323716096934921 560 390.909090909091 275 0.000382543381501149 35 1.06040440699762 1.06040440699762 1 8.09229103575716 556 64 682 216 35 873 642 564 275 237 156 220 M18728 GO_METALLOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 58/200 Gene Ontology MF GO:0008237 0.0839184282471183 0.184260033382694 365 303.909090909091 275 0.00793650793650794 91 1.46994345741293 1.63730222758413 1 5.53088626702606 361 332 275 301 192 734 262 152 91 157 486 221 M18075 GO_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_BINDING.html Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. 367/914 Gene Ontology MF GO:0019900 0.161385165508919 0.28120142475039 300 270.181818181818 276 0.0158730158730159 150 1.30041163865791 1.40520665618426 1 3.67011964443669 156 347 150 314 297 490 296 276 252 206 188 222 M18176 GO_INSULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin receptor. 17/46 Gene Ontology MF GO:0005158 0.0148080139147243 0.0772195358318408 100 273.181818181818 278 0.00135533044272177 63 1.82051220676583 1.82051220676583 1 10.3720955879499 96 641 280 531 63 278 190 98 320 349 159 223 M19081 GO_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 331/838 Gene Ontology MF GO:0016491 0.0365004958832698 0.123967534382894 575 374.727272727273 278 0.00337459374315623 107 1.16716618883691 1.33785592837091 1 5.42068395739734 574 210 278 507 120 107 614 776 256 408 272 224 M18121 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 118/368 Gene Ontology MF GO:0001228 0.128785280458767 0.244293727880548 245 302.636363636364 279 0.0124551312468814 120 1.25358367297628 1.49034255081905 1 3.93032579033262 188 348 120 257 242 429 279 316 245 447 458 225 M18432 GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 130/334 Gene Ontology MF GO:0005085 0.0839184282471183 0.184260033382694 340 347 279 0.00793650793650794 33 1.47526426976399 1.70885312257134 1 5.55090663485242 337 33 228 70 236 670 519 600 129 279 716 226 M18746 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 11/23 Gene Ontology MF GO:0016638 0.00694468300598354 0.0469787379816534 280 313.818181818182 279 0.000633336589109504 46 1.93847904430292 1.93847904430292 1 13.1872136217212 159 145 46 279 535 559 308 268 583 291 279 227 M19027 GO_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. 383/1167 Gene Ontology MF GO:0043565 0.0404021320792771 0.131839015811844 250 372.090909090909 281 0.00374215968143461 106 1.41515898296591 1.54311961992613 1 6.37863574665776 281 662 106 668 126 652 377 270 248 248 455 228 M18174 GO_THIOLESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOLESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. 24/40 Gene Ontology MF GO:0016790 0.0364821305812257 0.123967534382894 120 281.090909090909 282 0.00337286678392136 87 0.940767540772448 -0.940767540772448 -1 4.36921796845688 193 117 446 367 119 87 378 282 412 601 90 229 M17920 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 4/10 Gene Ontology MF GO:0016888 0.0978109958165404 0.203588498079677 265 306.545454545455 283 0.0102403312735439 105 0.446023024847912 -0.543167498892945 -1 1.57925386728013 265 283 618 320 273 136 105 378 357 518 119 230 M19054 GO_DOPAMINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a dopamine receptor. 9/31 Gene Ontology MF GO:0050780 0.0765897756730953 0.184260033382694 320 323.363636363636 283 0.00793650793650794 10 2.07682440132215 2.07682440132215 1 7.8143683600286 320 239 880 27 706 440 215 283 10 89 348 231 M18026 GO_PROTEIN_LIPID_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_BINDING.html Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. 8/37 Gene Ontology MF GO:0071814 0.0352182136340296 0.123967534382894 35 305.909090909091 284 0.00357891350084065 34 1.90919498657043 1.90919498657043 1 8.86689730849925 34 322 643 284 450 315 174 145 536 234 228 232 M18416 GO_RNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with an RNA polymerase molecule or complex. 21/48 Gene Ontology MF GO:0070063 0.0233701397280394 0.0994764046641727 95 268.727272727273 284 0.0021474683450272 46 1.0847880043884 1.0847880043884 1 5.56923433211249 94 270 455 358 384 284 46 160 324 378 203 233 M18522 GO_MANNOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 12/22 Gene Ontology MF GO:0000030 0.0547023523488932 0.159260013167664 200 344.909090909091 285 0.00510107510345804 82 0.284953135241018 -0.283689598318716 -1 1.16460802767081 197 447 525 643 285 98 82 102 509 710 196 234 M18552 GO_MODIFIED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a modified amino acid. 45/101 Gene Ontology MF GO:0072341 0.0230002699524153 0.098879665215991 285 351.818181818182 285 0.00211311905434622 70 1.43834611548491 1.43834611548491 1 7.40363196911261 325 404 73 285 637 882 284 70 283 204 423 235 M18337 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. 28/79 Gene Ontology MF GO:0015171 0.161385165508919 0.28120142475039 220 382.727272727273 289 0.0158730158730159 218 1.32018948758027 1.4836078808557 1 3.72593818100271 329 263 219 232 289 881 484 605 218 247 443 236 M18521 GO_PALMITOYL_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYL_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. 8/16 Gene Ontology MF GO:0016290 0.0054063523467649 0.0404377573904366 100 346.090909090909 289 0.000541955045040079 41 0.940767540772448 -0.940767540772448 -1 6.71369199653319 260 289 761 346 41 100 234 502 466 709 99 237 M18560 GO_MYOSIN_HEAVY_CHAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_HEAVY_CHAIN_BINDING.html Interacting selectively and non-covalently with a heavy chain of a myosin complex. 11/27 Gene Ontology MF GO:0032036 0.0839184282471183 0.184260033382694 245 372.181818181818 289 0.00793650793650794 105 2.07333958077616 -2.07333958077616 -1 7.801256191334 429 741 284 472 777 185 325 243 105 289 244 238 M18611 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS.html Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). 14/33 Gene Ontology MF GO:0016769 0.0142975243181843 0.0769223530568981 290 278.727272727273 289 0.00130829967572703 61 0.907956294871668 -1.23889395501682 -1 5.18073323983045 437 192 291 289 61 239 332 344 289 321 271 239 M18966 GO_PROTEIN_DOMAIN_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DOMAIN_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a specific domain of a protein. 375/931 Gene Ontology MF GO:0019904 0.180739618630813 0.306790496568908 290 326.454545454545 289 0.0179597945599365 137 1.2517384700655 1.37465453377297 1 3.29023082512232 289 222 145 169 275 863 321 451 414 137 305 240 M18499 GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. 33/77 Gene Ontology MF GO:0000979 0.0839184282471183 0.184260033382694 350 350.090909090909 290 0.00793650793650794 102 1.27837935180022 -1.0634682405883 -1 4.81009710859416 347 812 398 584 290 102 479 278 156 283 122 241 M18723 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. 11/32 Gene Ontology MF GO:0016538 0.0313567676831574 0.116402663015117 135 292.272727272727 290 0.00289207497864022 54 1.05077947290469 1.05077947290469 1 5.02732875777967 133 354 317 384 693 263 54 136 333 290 258 242 M18446 GO_LIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 8/19 Gene Ontology MF GO:0055102 0.00795250619935666 0.0515232796014657 745 370.272727272727 291 0.000798110942715308 35 1.9366898762468 1.9366898762468 1 12.7772196203093 745 291 742 158 50 642 457 115 35 239 599 243 M18010 GO_RETINOIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_BINDING.html Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. 4/31 Gene Ontology MF GO:0001972 0.098449633589914 0.203994736267389 280 408.090909090909 292 0.0103104162944724 121 0.607933581080008 0.659344700998517 1 2.14984208080114 278 187 636 180 292 912 499 629 209 546 121 244 M19086 GO_EPHRIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_ACTIVITY.html Combining with an ephrin to initiate a change in cell activity. 11/20 Gene Ontology MF GO:0005003 0.0839184282471183 0.184260033382694 265 295.545454545455 292 0.00793650793650794 144 1.31394404283802 1.31394404283802 1 4.94391468178221 262 144 268 331 355 590 221 311 148 292 329 245 M19192 GO_ARMADILLO_REPEAT_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARMADILLO_REPEAT_DOMAIN_BINDING.html Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. 5/19 Gene Ontology MF GO:0070016 0.0265832600656419 0.106333040262568 915 365 292 0.00269067207012612 53 0.672881436522253 0.731543462176766 1 3.35475668265366 92 359 912 292 481 53 90 120 620 913 83 246 M17881 GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. 62/204 Gene Ontology MF GO:0022853 0.00109945016496701 0.0142463965037978 295 320.272727272727 293 1e-04 16 1.48469505638914 1.79302506751023 1 14.0410615863405 293 102 82 16 435 808 547 634 97 41 468 247 M17973 GO_PROTEIN_HETERODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETERODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. 238/584 Gene Ontology MF GO:0046982 0.000579779255847729 0.00860317605451468 295 316.727272727273 293 5.27211004513761e-05 28 1.34856707777786 1.46776021453998 1 14.2667796705163 674 293 28 277 128 94 723 513 295 93 366 248 M18315 GO_POLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 10/23 Gene Ontology MF GO:0030247 0.106168488490335 0.216095153564398 245 359 293 0.0101515747702651 115 1.82051220676583 1.82051220676583 1 6.20452575684152 244 553 115 618 510 581 389 139 239 268 293 249 M18288 GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING.html Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. 23/59 Gene Ontology MF GO:0050431 0.00654068946575294 0.0452438669811481 365 315.727272727273 295 0.000596383320605428 42 1.13102433626656 1.13102433626656 1 7.78888080176594 363 278 272 295 440 655 396 42 377 96 259 250 M19021 GO_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. 189/493 Gene Ontology MF GO:0005543 0.0374651192109426 0.12443288690999 705 365.181818181818 295 0.0034653430364504 32 1.28204199965828 1.56067392856038 1 5.94351724600187 705 32 70 235 172 245 675 697 417 295 474 251 M17901 GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING.html Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. 15/23 Gene Ontology MF GO:0001965 0.104661745741284 0.213975124626624 300 290.454545454545 297 0.01 21 1.1866416600189 1.1866416600189 1 4.07024386796518 229 21 157 300 231 587 458 196 387 332 297 252 M18362 GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. 12/29 Gene Ontology MF GO:0008106 0.000210251466718902 0.00394757855880387 510 331 298 1.91155966271201e-05 7 0.995735176152667 -0.967459383376804 -1 12.2597085433921 510 254 318 354 7 442 914 141 126 298 277 253 M18080 GO_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. 14/27 Gene Ontology MF GO:0016289 0.0251582523612008 0.101962961111475 210 292.909090909091 300 0.00231369484255248 93 0.940767540772448 -0.940767540772448 -1 4.77817268511647 207 204 415 321 93 179 437 300 328 575 163 254 M18111 GO_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with an identical protein to form a homodimer. 398/1017 Gene Ontology MF GO:0042803 0.00188367662115684 0.0208793071260758 300 334.636363636364 300 0.000171390126581721 34 1.36562543251957 1.41475375165775 1 11.7537340733185 333 233 34 317 113 862 300 553 296 165 475 255 M18494 GO_PHOSPHATIDYLSERINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_BINDING.html Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. 25/62 Gene Ontology MF GO:0001786 0.0200255743634824 0.0935204488040803 155 331.727272727273 301 0.00183729228535596 65 1.51219857869234 1.51219857869234 1 7.97122774118652 152 585 151 402 493 551 200 65 541 208 301 256 M17882 GO_CYTOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_BINDING.html Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 59/153 Gene Ontology MF GO:0019955 0.169020044480083 0.290109031570292 155 312.636363636364 302 0.0166909192876916 105 1.23184715423366 1.23184715423366 1 3.39115298602116 154 403 185 406 503 532 255 179 415 105 302 257 M18982 GO_HISTONE_ACETYLTRANSFERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_ACETYLTRANSFERASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone acetyltransferase. 18/38 Gene Ontology MF GO:0035035 0.0499919923192519 0.151252910177875 305 344.909090909091 302 0.00465140901477107 69 0.452818962220064 0.543908039096269 1 1.90264123187354 116 422 164 611 302 225 69 302 604 854 125 258 M18188 GO_FAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 10/15 Gene Ontology MF GO:0071949 0.107720477260123 0.217330787454633 155 401.909090909091 304 0.0103079442285083 101 0.26392324274912 -0.294437109702136 -1 0.89613463921061 304 718 408 693 270 151 101 200 817 605 154 259 M18574 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 131/414 Gene Ontology MF GO:0000982 0.195628354114106 0.324870190947612 305 361.545454545455 304 0.0195958083237532 131 1.19242309605127 1.26659674837687 1 2.98242759784126 131 706 217 557 286 390 270 304 303 363 450 260 M18662 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. 5/31 Gene Ontology MF GO:0043395 0.00404682054604549 0.0338461354760168 305 360.363636363636 305 0.000405420903010831 19 1.28538370163399 1.41537451667822 1 9.68181380408111 305 100 794 58 746 600 617 75 259 19 391 261 M18676 GO_VITAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BINDING.html Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 36/91 Gene Ontology MF GO:0019842 0.0485734936203944 0.148463834321471 310 443 309 0.00451639165225429 76 1.59871435875801 -1.33376424024472 -1 6.78362321709573 913 306 76 268 600 526 832 159 113 309 771 262 M18819 GO_TITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TITIN_BINDING.html Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. 14/28 Gene Ontology MF GO:0031432 0.0994249163520371 0.20555263605365 165 382.181818181818 311 0.00947498475158527 135 0.485078032898842 -0.495137342587652 -1 1.70717699596286 162 415 263 344 851 135 311 135 621 806 161 263 M18748 GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any N-glycosyl bond. 9/26 Gene Ontology MF GO:0016799 0.0302178133605518 0.114404890089332 70 344.636363636364 312 0.00306367559412209 60 0.55936453995665 -0.55936453995665 -1 2.69775429094862 70 416 807 312 386 60 129 191 551 781 88 264 M19067 GO_TAU_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. 8/26 Gene Ontology MF GO:0050321 0.417238009185812 0.56603583603144 275 483.181818181818 312 0.052565659926295 133 0.493393016758395 -0.493393016758395 -1 0.624634238905762 271 133 887 229 615 248 309 773 655 883 312 265 M18378 GO_PALMITOYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. 19/36 Gene Ontology MF GO:0016409 0.00680841172387083 0.0463980650811938 315 349.181818181818 314 0.000620870334672052 30 0.353954938870264 -0.348673036564031 -1 2.41770112752069 314 298 429 632 114 104 448 238 562 672 30 266 M18794 GO_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_ACTIVITY.html Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. 40/144 Gene Ontology MF GO:0003774 0.0224060553138825 0.0972338249470373 240 455.818181818182 314 0.00205795991297447 45 0.708329498464269 -0.708329498464269 -1 3.67244914899575 237 837 172 869 850 45 314 255 574 796 65 267 M18019 GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 12/21 Gene Ontology MF GO:0030676 0.00589764422044919 0.0427230919906555 370 322 315 0.000537592173308971 40 0.889829409089437 -0.889829409089437 -1 6.24135363312921 368 193 315 184 40 291 289 396 402 550 514 268 M18061 GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. 37/89 Gene Ontology MF GO:0005546 0.0839184282471183 0.184260033382694 920 444.545454545455 315 0.00793650793650794 150 1.74404843680394 1.74404843680394 1 6.56224804947119 917 261 154 294 601 459 769 288 150 315 682 269 M18238 GO_STEROID_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_ACTIVITY.html Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. 19/63 Gene Ontology MF GO:0003707 0.0839184282471183 0.184260033382694 520 317.454545454545 315 0.00793650793650794 49 1.53457399821183 1.53457399821183 1 5.77406853210873 520 297 142 57 322 381 315 653 49 154 602 270 M19139 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. 63/141 Gene Ontology MF GO:0001085 0.00894537991758127 0.0563681474258546 855 410.090909090909 316 0.000816541906565043 51 1.50378242938551 1.7193104527397 1 9.62049232795568 854 154 202 197 51 424 713 729 290 316 581 271 M17938 GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 3/14 Gene Ontology MF GO:0099528 0.0196752392974529 0.0933052585240034 505 331.545454545455 317 0.00198516432390811 67 0.540370798448075 0.609784063903529 1 2.85121689826886 501 275 623 342 317 396 113 67 265 525 223 272 M18295 GO_CATION_SUGAR_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_SUGAR_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). 13/16 Gene Ontology MF GO:0005402 0.0819196490034107 0.184260033382694 345 318.090909090909 318 0.00773992440463052 88 0.717301207645577 -0.717301207645577 -1 2.6989550340065 342 93 342 281 318 88 287 448 484 642 174 273 M18471 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. 11/22 Gene Ontology MF GO:0016722 0.0839184282471183 0.184260033382694 320 310.909090909091 318 0.00793650793650794 43 1.31212748984869 -0.831099373833084 -1 4.93707962415886 225 388 365 318 374 262 317 514 43 287 327 274 M19011 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery. 53/114 Gene Ontology MF GO:0001104 0.000803102608470051 0.0113669907660376 805 338.727272727273 318 7.30359934814139e-05 11 1.10597326277692 1.21032960265383 1 11.0149281683532 801 37 395 45 11 318 805 289 114 394 517 275 M19149 GO_MONOCARBOXYLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BINDING.html Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). 32/99 Gene Ontology MF GO:0033293 0.0591643010424346 0.167480482950892 150 308.090909090909 318 0.00552890966477399 79 1.51430131785667 1.51430131785667 1 6.01943380910561 150 318 79 223 246 418 205 529 473 426 322 276 M18384 GO_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any phosphatase. 97/251 Gene Ontology MF GO:0019902 0.232850105696956 0.366191619215725 410 415.909090909091 319 0.0238095238095238 207 1.61053642164264 1.61053642164264 1 3.59922489186288 406 234 214 207 562 887 632 319 297 246 571 277 M19217 GO_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 11/37 Gene Ontology MF GO:0005272 0.0611276623936607 0.169901659825281 320 329.090909090909 319 0.00571775150881949 21 1.42547008159903 1.5361147374397 1 5.62081049474629 319 531 168 116 887 513 549 155 21 42 319 278 M17916 GO_PROTEIN_SELF_ASSOCIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SELF_ASSOCIATION.html Interacting selectively and non-covalently with a domain within the same polypeptide. 27/71 Gene Ontology MF GO:0043621 0.0401073315656335 0.131781232287082 305 327.727272727273 320 0.00371433966447486 91 1.32607824626564 1.32607824626564 1 5.97840970313092 303 413 234 195 539 469 320 91 422 224 395 279 M18234 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells. 19/39 Gene Ontology MF GO:1901505 0.298735036746822 0.443284248075929 480 355.727272727273 320 0.0317460317460317 231 1.90919498657043 1.90919498657043 1 3.45523239226312 477 320 383 293 638 231 251 245 315 367 393 280 M18889 GO_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BINDING.html Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 146/308 Gene Ontology MF GO:0048037 0.0038353320180333 0.0323716096934921 155 283.727272727273 320 0.000349275876588502 12 1.08693256939984 -1.18998019586408 -1 8.29473607754756 153 500 298 481 160 12 374 320 459 327 37 281 M18581 GO_IDENTICAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IDENTICAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with an identical protein or proteins. 696/1724 Gene Ontology MF GO:0042802 0.0735733215104004 0.184260033382694 225 367.545454545455 321 0.00761291132869603 114 1.33069438270703 1.39189475336144 1 5.0069403897509 221 346 773 442 180 793 264 321 184 114 405 282 M18907 GO_PDZ_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PDZ_DOMAIN_BINDING.html Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. 53/141 Gene Ontology MF GO:0030165 0.232850105696956 0.366191619215725 270 383.727272727273 321 0.0238095238095238 87 1.35034582038557 1.35034582038557 1 3.01775122119724 267 393 305 447 395 867 578 269 292 87 321 283 M18261 GO_VITAMIN_D_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. 8/22 Gene Ontology MF GO:0042809 0.452546077865415 0.60514882505259 325 418.454545454545 322 0.0584687108430138 261 0.241113363873248 -0.263939501779705 -1 0.269409928714774 322 342 700 305 446 261 292 309 711 630 285 284 M17889 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. 11/26 Gene Ontology MF GO:0080025 0.12876364281548 0.244293727880548 315 374.272727272727 325 0.0124529015593704 120 0.21648249509956 -0.212767244290894 -1 0.678731390537306 315 424 546 467 287 120 152 325 777 509 195 285 M18164 GO_TRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_BINDING.html Interacting selectively and non-covalently with transfer RNA. 17/47 Gene Ontology MF GO:0000049 0.253601753259309 0.389653270082534 150 383.181818181818 326 0.026240127774741 146 0.738664740866751 -0.738664740866751 -1 1.54872272645617 146 663 577 604 326 209 238 303 346 599 204 286 M18455 GO_CO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CO_SMAD_BINDING.html Interacting selectively and non-covalently with a common mediator SMAD signaling protein. 8/19 Gene Ontology MF GO:0070410 0.147859119791321 0.270976872924334 215 395.545454545455 326 0.0158730158730159 198 0.398570875469609 -0.499182247089819 -1 1.15771610351966 215 494 744 316 517 247 326 363 198 693 238 287 M19039 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. 6/76 Gene Ontology MF GO:0016712 0.264618278775312 0.401068890400802 245 363.636363636364 326 0.0302689913358263 195 2.01369544572059 2.01369544572059 1 4.09266564039294 243 409 874 201 356 326 518 223 363 195 292 288 M19212 GO_MRNA_3_UTR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_UTR_BINDING.html Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. 25/64 Gene Ontology MF GO:0003730 0.0863606873401547 0.187829390905301 775 419.727272727273 326 0.00817723849806386 107 1.34373861851409 1.4346766736595 1 4.99866955590248 771 213 326 267 187 455 890 318 442 107 641 289 M18573 GO_ACETYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_BINDING.html Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. 3/20 Gene Ontology MF GO:0042166 0.0165284799668946 0.0826499009083662 330 338.090909090909 327 0.00166527182784688 32 0.590982498919026 0.737051846342935 1 3.27768690908225 327 80 772 202 70 432 213 511 32 725 355 290 M18130 GO_ATPASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_REGULATOR_ACTIVITY.html Modulates the rate of ATP hydrolysis by an ATPase. 21/45 Gene Ontology MF GO:0060590 0.132149581150912 0.250159700944112 300 367.545454545455 328 0.0128024252374201 106 0.300812626041004 -0.325229319961397 -1 0.927250888140433 296 106 568 352 606 122 316 328 558 589 202 291 M18700 GO_CORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 21/48 Gene Ontology MF GO:0015026 0.151619752659996 0.27731644621709 175 367.545454545455 329 0.0148366844676592 128 1.20374836015859 1.20374836015859 1 3.43456301582781 174 576 235 581 710 329 128 185 601 177 347 292 M19019 GO_NEUROTROPHIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neurotrophin receptor. 14/21 Gene Ontology MF GO:0005165 0.0501436278307086 0.151252910177875 725 462.272727272727 329 0.00466585302164365 72 1.17628946726973 1.17628946726973 1 4.94249827926311 724 72 329 102 146 741 764 721 316 324 846 293 M18690 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 85/280 Gene Ontology MF GO:0001077 0.165568255210202 0.28632104284471 330 395 330 0.0163202961929435 211 1.28784281959724 1.41157746371 1 3.58295715149119 236 684 211 530 267 516 328 330 302 452 489 294 M18651 GO_LIPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 14/21 Gene Ontology MF GO:0060229 0.0855977962119243 0.187054566543873 255 384.272727272727 331 0.00810197846705265 185 0.421639498719582 0.536129945751296 1 1.57236413700003 247 253 331 377 185 636 304 251 334 752 557 295 M19031 GO_DEATH_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_ACTIVITY.html Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. 12/23 Gene Ontology MF GO:0005035 0.161385165508919 0.28120142475039 310 459.272727272727 331 0.0158730158730159 160 1.86280643978199 1.86280643978199 1 5.25735265922551 852 483 160 428 299 310 331 809 229 306 845 296 M17855 GO_BETA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_BINDING.html Interacting selectively and non-covalently with the beta subunit of the catenin complex. 43/129 Gene Ontology MF GO:0008013 0.0878855807339142 0.19069512800755 570 383.818181818182 333 0.00832784225064138 169 1.10971525652873 1.10971525652873 1 4.09072936523858 569 333 249 556 188 169 176 540 691 444 307 297 M19198 GO_OXIDIZED_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDIZED_NAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. 7/18 Gene Ontology MF GO:0070403 0.0765897756730953 0.184260033382694 915 421.272727272727 333 0.00793650793650794 58 0.445063560953374 0.495570581342415 1 1.67461937558485 312 343 913 206 653 408 333 163 58 915 330 298 M18391 GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE.html The action of a molecule that contributes to the structural integrity of a muscle fiber. 27/67 Gene Ontology MF GO:0008307 0.00371728833474037 0.0321953876871856 150 296.909090909091 335 0.00033850765889673 44 2.08447839848189 -2.07333958077616 -1 15.932644837407 148 482 44 383 605 64 107 443 430 225 335 299 M19117 GO_RECEPTOR_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INHIBITOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. 5/14 Gene Ontology MF GO:0030547 0.25369816171678 0.389653270082534 140 435.818181818182 335 0.0288385136177489 139 1.7354036805309 1.7354036805309 1 3.63853736267704 139 725 897 535 780 410 169 335 317 173 314 300 M18096 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. 6/20 Gene Ontology MF GO:0030169 0.166682727386186 0.287707521942385 580 371 336 0.0180688479206464 69 1.90919498657043 1.90919498657043 1 5.29112836454748 69 430 664 313 579 397 282 246 577 188 336 301 M18226 GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. 32/94 Gene Ontology MF GO:0008081 0.0839184282471183 0.184260033382694 285 367.090909090909 336 0.00793650793650794 151 1.38368769660793 -0.946863186450032 -1 5.20633581410232 285 296 175 336 825 409 166 619 151 425 351 302 M17959 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. 57/142 Gene Ontology MF GO:0016616 0.0211972246346231 0.0946672168148218 340 383.272727272727 337 0.00194584183943475 80 1.05128274519547 -1.03930531889345 -1 5.51310692236099 826 304 369 337 80 379 865 337 170 152 397 303 M19163 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. 12/82 Gene Ontology MF GO:0016709 0.133806486857601 0.25277611480286 890 519.727272727273 337 0.0129739163016903 159 1.59195221079983 -1.59195221079983 -1 4.87032481510019 890 205 159 304 245 916 901 666 337 307 787 304 M18165 GO_CALCIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_BINDING.html Interacting selectively and non-covalently with calcium ions (Ca2+). 266/853 Gene Ontology MF GO:0005509 3.52812621921123e-14 1.62293806083717e-11 35 289.454545454545 339 3.20738747201025e-15 2 1.61890988852204 1.72406067948113 1 89.473322635783 339 31 2 31 377 901 375 385 127 6 610 305 M19098 GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS.html Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 28/44 Gene Ontology MF GO:0016875 0.248203939710483 0.383777520224612 600 474.727272727273 339 0.0256020361346434 141 0.229529675871084 -0.271598353584462 -1 0.489001973315133 141 597 597 779 323 201 339 334 722 886 303 306 M18199 GO_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 20/52 Gene Ontology MF GO:0005504 0.173531364858281 0.296194537420442 225 298.909090909091 340 0.0171774212299828 100 1.51430131785667 1.51430131785667 1 4.09878898181861 100 453 111 225 413 340 133 418 502 372 221 307 M18286 GO_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. 115/269 Gene Ontology MF GO:0035091 0.196597686343338 0.325558685615367 400 376.545454545455 340 0.0197032731601389 136 1.22476235518814 -0.791976421010708 -1 3.0575448555239 400 136 183 273 560 157 340 910 489 441 253 308 M18447 GO_CHROMATIN_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DNA_BINDING.html Interacting selectively and non-covalently with DNA that is assembled into chromatin. 53/136 Gene Ontology MF GO:0031490 0.000561517664613023 0.00849900491799579 235 326.818181818182 340 5.10600940888044e-05 10 0.993953168185642 -1.33403223803043 -1 10.5421798274515 231 375 276 436 765 11 228 459 340 464 10 309 M18462 GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. 16/35 Gene Ontology MF GO:0004033 0.00164030440781766 0.0187028284809452 340 419.818181818182 341 0.000149229880480644 20 0.959263543187982 0.955165623093571 1 8.49115109811563 754 299 341 340 20 609 739 507 136 338 535 310 M19175 GO_ACID_THIOL_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_THIOL_LIGASE_ACTIVITY.html Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 8/20 Gene Ontology MF GO:0016878 0.000312620756776916 0.00542662445725967 55 424.818181818182 342 3.12664744768391e-05 10 0.816391131298516 -0.816391131298516 -1 9.47366952202527 620 51 907 55 10 342 272 843 310 905 358 311 M18428 GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS.html Catalysis of the hydrolysis of any glycosyl bond. 49/134 Gene Ontology MF GO:0016798 0.0839184282471183 0.184260033382694 580 411 343 0.00793650793650794 102 2.03954166489903 2.53293403987983 1 7.67408637909851 578 452 118 208 858 260 343 616 102 229 757 312 M18374 GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY.html Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. 7/12 Gene Ontology MF GO:0031543 0.0765897756730953 0.184260033382694 345 432.272727272727 345 0.00793650793650794 54 1.8636644772713 1.8636644772713 1 7.01232164163849 548 428 727 91 345 907 911 189 54 213 342 313 M19029 GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 117/338 Gene Ontology MF GO:0003714 0.0106476293418334 0.0636092142499135 470 412.909090909091 345 0.00097268308856139 55 1.28913619568391 1.36837616983986 1 7.90070463309663 470 295 345 429 55 562 337 791 246 318 694 314 M19028 GO_GTP_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. 14/22 Gene Ontology MF GO:0030742 0.123262156966693 0.2352886341512 905 494.727272727273 346 0.0118876187068502 92 0.950881394926272 1.04424153730406 1 3.06071893294877 905 92 346 130 235 671 919 788 216 325 815 315 M19155 GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. 25/52 Gene Ontology MF GO:0019205 0.114051575508394 0.226136744542505 130 423.818181818182 347 0.0109484016926139 108 0.254666938097972 -0.276024826541831 -1 0.842203481237368 128 598 553 623 221 108 218 347 824 901 141 316 M18094 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the epidermal growth factor receptor. 22/47 Gene Ontology MF GO:0005154 0.187945503113237 0.314627548899387 280 393.181818181818 349 0.0187481907463225 139 1.21455215107271 1.21455215107271 1 3.12433266001645 280 308 261 349 636 300 139 698 462 386 506 317 M18411 GO_CATION_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 30/70 Gene Ontology MF GO:0019829 0.250634967242584 0.3868861910456 465 366.363636363636 349 0.0258888979217383 211 1.07384400443659 -0.916099069114754 -1 2.26850158352923 461 349 336 360 547 275 611 211 381 264 235 318 M18754 GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 4/21 Gene Ontology MF GO:0005248 0.00699751707772447 0.0469906256314344 250 383.545454545455 350 0.000701964958722581 47 1.29994081892301 1.29994081892301 1 8.84259178820697 249 675 809 350 550 542 491 47 80 148 278 319 M17943 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION.html Any protein binding that is involved in cell adhesion. 10/21 Gene Ontology MF GO:0098631 0.0839184282471183 0.184260033382694 795 337.363636363636 351 0.00793650793650794 26 1.56693020094789 -1.22554810741938 -1 5.89581367880823 792 379 285 72 423 276 551 351 26 97 459 320 M18568 GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. 17/31 Gene Ontology MF GO:0004683 0.174459461012621 0.297227229873354 360 364.090909090909 351 0.0172778066913542 120 1.53334444632203 1.53334444632203 1 4.13846139956678 412 120 339 256 296 715 134 357 360 351 665 321 M19111 GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY.html Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 5/27 Gene Ontology MF GO:0005326 0.0358904290480239 0.123967534382894 390 403.727272727273 352 0.00364836130001673 122 1.62371583222612 1.62371583222612 1 7.54104300720036 388 231 894 224 122 751 666 134 352 172 507 322 M18412 GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. 32/83 Gene Ontology MF GO:0042625 0.213873102663956 0.343818502708482 505 381.545454545455 353 0.0216385492581821 198 1.07384400443659 -0.916099069114754 -1 2.55042453060684 503 387 328 353 620 299 591 198 382 280 256 323 M18407 GO_FIBROBLAST_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with a fibroblast growth factor. 14/55 Gene Ontology MF GO:0017134 0.198032388455439 0.327091198166974 200 346.181818181818 354 0.0198625476820211 142 1.08918898596586 1.08918898596586 1 2.70771516539959 198 363 354 191 405 569 142 433 611 320 222 324 M19042 GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). 6/23 Gene Ontology MF GO:0005416 0.00621183479694067 0.0439606770245032 285 394 354 0.000622926752047562 45 1.62371583222612 1.62371583222612 1 11.285761402737 284 408 877 287 425 593 520 45 354 196 345 325 M18443 GO_RNA_POLYMERASE_CORE_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_CORE_ENZYME_BINDING.html Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. 11/29 Gene Ontology MF GO:0043175 0.0278564528252184 0.109991144202579 340 358 355 0.00256505036254816 61 1.0847880043884 1.0847880043884 1 5.32675891019241 336 355 456 378 97 619 306 592 61 286 452 326 M18579 GO_CHAPERONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_BINDING.html Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. 67/131 Gene Ontology MF GO:0051087 0.144238628853938 0.267678113665751 185 349.454545454545 355 0.0140605515877257 129 1.26503080425563 1.4514343866288 1 3.70896341108878 184 556 381 633 378 129 355 286 490 202 250 327 M18043 GO_DNA_N_GLYCOSYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_N_GLYCOSYLASE_ACTIVITY.html Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. 7/17 Gene Ontology MF GO:0019104 0.0536877324061498 0.157301636349229 100 333 356 0.00550306951193582 75 0.55936453995665 -0.55936453995665 -1 2.30152819579938 97 450 648 356 414 75 130 173 664 561 95 328 M18084 GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. 2/7 Gene Ontology MF GO:0004523 0.240203603165697 0.374554771038035 320 436.4 357.5 0.0300616375681216 222 0.349183909410957 -0.349183909410957 -1 0.76281489448693 317 439 662 NA 341 222 334 374 774 577 324 329 M18454 GO_OLIGOPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOPEPTIDE_BINDING.html Interacting selectively and non-covalently with an oligopeptide. 10/20 Gene Ontology MF GO:1900750 0.0906584861150502 0.193516954120293 815 477.909090909091 358 0.00860229149833655 191 1.29064118907003 1.29064118907003 1 4.71550001633278 815 256 273 303 191 493 672 869 358 269 758 330 M18686 GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY.html Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. 15/25 Gene Ontology MF GO:0042813 0.161385165508919 0.28120142475039 185 390.636363636364 359 0.0158730158730159 182 2.35459573801311 2.35459573801311 1 6.6453174997825 390 214 182 182 518 900 649 359 205 335 363 331 M17974 GO_PROTEIN_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any protein phosphatase. 79/199 Gene Ontology MF GO:0019903 0.147606675504912 0.270976872924334 475 374.181818181818 360 0.014413947214686 161 1.7891498767436 1.7891498767436 1 5.19688703980622 334 303 186 308 360 733 403 161 474 381 473 332 M17897 GO_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. 52/152 Gene Ontology MF GO:0016597 0.0175615389299981 0.0863990150566751 555 376 361 0.00160939192340573 59 1.53878312272817 1.51219857869234 1 8.3824874168138 551 211 59 170 361 811 472 142 378 252 729 333 M18047 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS.html Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). 32/68 Gene Ontology MF GO:0016765 0.071237903899664 0.184260033382694 545 424.181818181818 361 0.00669590539232377 79 2.76431492756404 2.76431492756404 1 10.4011562984831 545 361 358 445 171 351 789 811 79 424 332 334 M18151 GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. 131/498 Gene Ontology MF GO:0022803 0.00277798322875036 0.0268194823689389 45 349.090909090909 362 0.000252863386950435 41 1.50799310605903 1.67183114053919 1 12.1391714382394 291 466 41 319 475 634 362 481 236 43 492 335 M17854 GO_COFACTOR_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORTER_ACTIVITY.html Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. 11/23 Gene Ontology MF GO:0051184 0.161385165508919 0.28120142475039 665 453.181818181818 364 0.0158730158730159 195 0.514815445050005 -0.376512008035695 -1 1.45295082940743 662 356 281 311 329 809 364 478 195 499 701 336 M17880 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. 19/59 Gene Ontology MF GO:0016620 0.00233576312476528 0.0236143085141106 835 381.545454545455 364 0.000212567883765131 26 0.965763951394085 -0.889162256391105 -1 8.04772926339124 831 62 194 140 26 640 658 464 278 364 540 337 M18027 GO_CARBOXY_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_LYASE_ACTIVITY.html Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. 14/37 Gene Ontology MF GO:0016831 0.10377934712269 0.213118302126953 365 421.818181818182 364 0.00991134041110681 116 1.23889395501682 -1.23889395501682 -1 4.26053007013699 364 761 292 725 437 249 385 203 789 319 116 338 M19084 GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING.html Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. 147/461 Gene Ontology MF GO:0001159 0.298735036746822 0.443284248075929 365 457.636363636364 364 0.0317460317460317 200 1.27687061921076 1.32790667834416 1 2.31086120976776 200 811 277 816 364 530 361 339 350 438 548 339 M19219 GO_STRUCTURE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. 74/179 Gene Ontology MF GO:0043566 0.013679259350376 0.0753587940260234 190 372.636363636364 364 0.00125136933812723 34 0.993953168185642 -1.33403223803043 -1 5.71683247322234 190 708 364 810 594 34 196 293 393 475 42 340 M18767 GO_TYPE_I_INTERFERON_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_I_INTERFERON_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). 2/17 Gene Ontology MF GO:0005132 0.313602965114135 0.458155127830397 245 481.8 364.5 0.0409489813064304 223 0.295208635798748 0.295208635798748 1 0.512594753648613 245 603 811 NA 373 294 223 356 788 785 340 341 M19040 GO_ARYLSULFATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYLSULFATASE_ACTIVITY.html Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. 4/10 Gene Ontology MF GO:0004065 0.042858473496217 0.137386047444319 875 460.909090909091 365 0.00437082132334145 142 0.420472921397872 -0.377652229389004 -1 1.85667448097794 655 316 875 365 142 224 359 377 335 871 551 342 M18222 GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS.html The action of a molecule that contributes to the structural integrity of the lens of an eye. 5/22 Gene Ontology MF GO:0005212 0.0605203169711354 0.169668966372244 105 357.363636363636 366 0.00622346210129575 103 0.543716286463231 0.577465685210149 1 2.14560032397132 103 366 692 438 400 259 232 109 540 617 175 343 M18352 GO_INTERLEUKIN_1_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the interleukin-1 receptor. 20/51 Gene Ontology MF GO:0005149 0.106896056903661 0.216799024908599 355 374 366 0.0102248496183048 118 1.51592239515581 1.51592239515581 1 5.15548040327115 354 578 372 559 683 475 236 212 366 161 118 344 M18897 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 67/180 Gene Ontology MF GO:0016614 0.0101287800967355 0.0613057742697146 825 397.636363636364 366 0.000925065065124197 54 1.05128274519547 -1.03930531889345 -1 6.52923617891273 821 190 366 328 54 448 830 548 157 203 429 345 M18115 GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING.html Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. 334/977 Gene Ontology MF GO:0001067 0.0483660827934617 0.148322653899949 370 402.818181818182 369 0.00449666494617187 75 1.32107310362372 1.41820815593926 1 5.60833900903141 369 507 75 470 183 800 544 338 247 199 699 346 M18293 GO_MANNOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSE_BINDING.html Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. 7/23 Gene Ontology MF GO:0005537 0.272760436195694 0.412051890476253 280 421.727272727273 369 0.031348066324259 183 0.425960590920045 -0.547670818902459 -1 0.840128891885617 183 323 705 382 557 279 276 227 698 640 369 347 M18707 GO_CHEMOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_BINDING.html Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 12/31 Gene Ontology MF GO:0019956 0.203294957378874 0.332204903709706 335 480.272727272727 369 0.0204490019539554 145 1.56054462896803 1.56054462896803 1 3.82564785070789 335 767 231 608 831 369 145 659 712 303 323 348 M18826 GO_HSP70_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP70_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. 19/36 Gene Ontology MF GO:0030544 0.205279051631254 0.334259694691599 235 373.818181818182 369 0.0206710215035835 165 1.13975148755868 -1.13975148755868 -1 2.77844650564947 232 265 403 552 640 165 462 252 595 369 177 349 M19110 GO_NUCLEOTIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. 11/28 Gene Ontology MF GO:0019201 0.0022551871068441 0.0233116103944839 280 382.363636363636 370 0.000205227471684443 23 0.265435971986875 -0.272369756845968 -1 2.21950083073683 277 370 503 410 23 131 288 430 744 890 140 350 M18518 GO_CHANNEL_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_INHIBITOR_ACTIVITY.html Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 23/62 Gene Ontology MF GO:0016248 0.0839184282471183 0.184260033382694 165 354.545454545455 371 0.00793650793650794 154 2.24458518468169 2.24458518468169 1 8.44559388878224 164 508 371 435 512 436 294 348 154 395 283 351 M18336 GO_TROPOMYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPOMYOSIN_BINDING.html Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. 6/14 Gene Ontology MF GO:0005523 0.0121696670261706 0.0686876911906563 205 416 372 0.00122368306258409 60 0.749290985610367 0.538895173169404 1 4.46413192594442 204 149 717 421 60 495 269 908 322 659 372 352 M18393 GO_SH2_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH2_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. 21/52 Gene Ontology MF GO:0042169 0.0530149166930639 0.157301636349229 375 365.545454545455 372 0.00493975340322133 149 1.2781333237524 1.2781333237524 1 5.25893182775923 372 397 322 167 149 817 646 425 173 176 377 353 M18290 GO_SH3_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. 61/157 Gene Ontology MF GO:0017124 0.0152695990621406 0.0784806208780413 415 317.818181818182 373 0.00139787478027812 51 1.06745328062975 1.06745328062975 1 6.04318799186184 76 618 373 686 568 121 108 71 411 413 51 354 M18341 GO_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. 20/106 Gene Ontology MF GO:0005253 0.0839184282471183 0.184260033382694 160 365.454545454545 373 0.00793650793650794 39 2.05390742852465 2.05390742852465 1 7.72813975533422 486 157 266 214 418 879 411 373 39 160 617 355 M18793 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin-like growth factor receptor. 6/26 Gene Ontology MF GO:0005159 0.0366512710349427 0.123967534382894 265 415.454545454545 373 0.0037270178682921 125 0.426436683621375 0.566017128043683 1 1.98050492630584 264 243 819 351 125 392 474 209 525 795 373 356 M18879 GO_PEPTIDOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDOGLYCAN_BINDING.html Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. 4/26 Gene Ontology MF GO:0042834 0.00368570534296086 0.0321953876871856 360 405.727272727273 373 0.000369183264137683 31 1.29644110978073 1.29644110978073 1 9.90930664490264 356 373 837 188 809 449 452 31 355 150 463 357 M19214 GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. 10/25 Gene Ontology MF GO:0070273 0.00907168081182074 0.0563915293707776 840 457.727272727273 373 0.000828118653620521 52 1.12435455232976 -0.764161110170704 -1 7.1920539841117 840 315 289 274 52 662 681 445 373 278 826 358 M18952 GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. 28/83 Gene Ontology MF GO:0070491 0.101500239334809 0.209372691004539 375 357 375 0.00968271219338308 143 0.881230065715539 0.881230065715539 1 3.06529165481061 375 421 427 466 208 709 167 143 374 412 225 359 M18244 GO_RNA_CAP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING.html Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. 11/18 Gene Ontology MF GO:0000339 0.0218089836140805 0.0955441186902575 525 402.363636363636 376 0.00200256625054681 84 0.293813188796674 -0.338965708926706 -1 1.53478013015044 524 255 547 376 84 411 749 188 293 624 375 360 M18402 GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 21/46 Gene Ontology MF GO:0008138 0.157969912347299 0.28120142475039 355 422.181818181818 377 0.0155093385549925 258 0.903622821473322 0.903622821473322 1 2.55027232494586 539 350 355 355 258 597 380 416 342 377 675 361 M18620 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. 24/54 Gene Ontology MF GO:0004520 0.0709572256920891 0.184260033382694 125 350.181818181818 378 0.00666861975503138 83 0.295144801958102 -0.340186391499578 -1 1.1105271841812 121 378 514 571 170 83 127 417 597 737 137 362 M18950 GO_ACTIN_MONOMER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MONOMER_BINDING.html Interacting selectively and non-covalently with monomeric actin, also known as G-actin. 18/36 Gene Ontology MF GO:0003785 0.161385165508919 0.28120142475039 710 433 379 0.0158730158730159 220 1.53351475005755 -2.07333958077616 -1 4.32800082243477 709 405 335 347 379 363 633 582 220 357 433 363 M18923 GO_DOPAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_BINDING.html Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. 3/12 Gene Ontology MF GO:0035240 0.00634983317093171 0.0445697051687777 735 464 380 0.000636805064799862 46 0.858982002181133 0.858982002181133 1 5.94412892279724 380 244 851 333 263 735 735 46 401 841 275 364 M17981 GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 37/157 Gene Ontology MF GO:0022843 0.161385165508919 0.28120142475039 235 406.727272727273 382 0.0158730158730159 92 1.42814176955833 1.42992471355916 1 4.03060925128091 234 846 132 594 627 540 295 382 242 92 490 365 M18543 GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. 50/118 Gene Ontology MF GO:1902936 0.298735036746822 0.443284248075929 630 413.545454545455 382 0.0317460317460317 199 1.74404843680394 1.74404843680394 1 3.15635263656044 626 285 199 307 770 226 470 528 345 382 411 366 M18736 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 52/149 Gene Ontology MF GO:0001078 0.23531264594082 0.369432822978762 155 397.454545454545 383 0.024094809175293 151 0.934909162805569 0.900454857837673 1 2.0710065412156 151 625 362 749 315 283 172 383 492 393 447 367 M18042 GO_PROTEASOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_BINDING.html Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. 10/20 Gene Ontology MF GO:0070628 0.0544189588107266 0.158937911447201 220 369.272727272727 384 0.00507396392043847 71 0.324794853397141 -0.312662136811184 -1 1.32890457366588 218 365 410 576 628 76 71 384 670 560 104 368 M17908 GO_CYTOSKELETAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). 431/1066 Gene Ontology MF GO:0008092 0.00194043563762633 0.0212171345674405 880 439.363636363636 385 0.000176559022697486 35 1.25871556108162 1.3385817620992 1 10.7886337394045 877 385 35 494 309 77 804 765 255 347 485 369 M18642 GO_ORGANIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BINDING.html Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage. 104/287 Gene Ontology MF GO:0043177 1.52016463529438e-05 0.00055942058578833 475 381.727272727273 385 1.38197739953569e-06 20 1.53886818638822 1.60059073812816 1 25.6358949667076 471 166 20 71 178 877 504 614 385 164 749 370 M18981 GO_LIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BINDING.html Interacting selectively and non-covalently with a lipid. 309/886 Gene Ontology MF GO:0008289 0.0015315024242014 0.0182984705229259 820 400.272727272727 386 0.00013932450914768 33 1.29591056114219 1.46068568283064 1 11.5340740161903 816 67 33 199 115 454 838 633 386 122 740 371 M17932 GO_NARROW_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NARROW_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. 6/17 Gene Ontology MF GO:0022842 0.0434721731407834 0.138608288003469 350 399.090909090909 387 0.00443467746426683 67 1.53960170275972 1.53960170275972 1 6.76805607987182 346 673 622 503 731 387 67 174 461 186 240 372 M18959 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. 44/103 Gene Ontology MF GO:0016811 0.117332983621069 0.229510390624538 540 423.727272727273 387 0.0112819896339944 111 0.322053274225601 -0.33897482744815 -1 1.0544462065941 352 538 515 540 295 111 387 371 506 849 197 373 M18974 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/73 Gene Ontology MF GO:0016903 0.000968499837249077 0.0132988037353605 205 433.636363636364 389 8.80842236525458e-05 13 0.965763951394085 -0.889162256391105 -1 9.28129984845295 899 201 204 210 13 681 654 643 281 389 595 374 M18016 GO_ENHANCER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENHANCER_BINDING.html Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. 56/142 Gene Ontology MF GO:0035326 0.0980565134867659 0.203638809047008 565 353.272727272727 390 0.00933825373520299 134 0.723389170743516 -0.792904243146179 -1 2.56093916782614 561 442 137 390 202 134 338 432 517 548 185 375 M17958 GO_SIGNAL_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. 16/50 Gene Ontology MF GO:0005048 0.183197553248162 0.309819391522627 535 392.454545454545 391 0.0182280063972236 119 0.369591249441759 -0.398355384465128 -1 0.963403746599334 119 351 425 585 533 146 319 391 730 532 186 376 M18848 GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). 21/28 Gene Ontology MF GO:0015295 0.123270784413998 0.2352886341512 390 420.909090909091 394 0.0118885026577889 119 0.717301207645577 -0.717301207645577 -1 2.30886561259958 472 279 387 394 390 119 444 530 590 817 208 377 M19070 GO_RIBOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BINDING.html Interacting selectively and non-covalently with any part of a ribosome. 30/56 Gene Ontology MF GO:0043022 0.0674000324488664 0.181310028809816 390 422.090909090909 394 0.00632346126991417 162 1.35593454827845 1.35593454827845 1 5.15059322621724 386 394 564 371 167 162 573 599 626 420 381 378 M17877 GO_LONG_CHAIN_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 12/26 Gene Ontology MF GO:0036041 0.237885004327453 0.372201027179008 570 378.818181818182 395 0.0243937102582784 125 1.51430131785667 1.51430131785667 1 3.329325773103 217 569 125 395 609 367 171 444 570 296 404 379 M18529 GO_WW_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WW_DOMAIN_BINDING.html Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. 16/34 Gene Ontology MF GO:0050699 0.161385165508919 0.28120142475039 530 471.727272727273 395 0.0158730158730159 176 0.955385018378726 -0.955385018378726 -1 2.69635950015097 529 202 309 176 838 737 395 661 213 339 790 380 M18173 GO_GLYCINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_BINDING.html Interacting selectively and non-covalently with glycine, aminoethanoic acid. 5/15 Gene Ontology MF GO:0016594 0.0373890389901264 0.12443288690999 310 344.727272727273 397 0.0038033424316088 79 0.493678416225202 -0.775367661406186 -1 2.28868170624091 308 472 680 424 397 128 100 199 405 600 79 381 M18629 GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. 2/22 Gene Ontology MF GO:0015106 0.13411491204602 0.25283958828348 235 434.7 397 0.0158730158730159 116 1.67949129323189 1.67949129323189 1 5.1371986860031 233 583 783 NA 485 375 291 874 188 116 419 382 M18797 GO_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. 291/803 Gene Ontology MF GO:0008134 0.0149387043471666 0.0772195358318408 580 422.090909090909 397 0.00136737435034876 64 1.31239713474783 1.43141346468094 1 7.47718604124226 576 151 230 204 64 635 659 638 178 397 911 383 M19171 GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any O-glycosyl bond. 39/105 Gene Ontology MF GO:0004553 0.0762186319286909 0.184260033382694 900 455.636363636364 397 0.00718134908134257 75 2.53293403987983 2.53293403987983 1 9.53055042595969 896 376 85 120 711 575 785 397 75 163 829 384 M18046 GO_PROTEIN_DIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DIMERIZATION_ACTIVITY.html The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. 581/1514 Gene Ontology MF GO:0046983 0.0243284685319988 0.0994764046641727 690 461.727272727273 398 0.00245989896170463 96 1.35257986945419 1.39442371939365 1 6.94406119226207 686 245 650 362 96 398 575 914 299 103 751 385 M18368 GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a protein serine/threonine kinase. 19/35 Gene Ontology MF GO:0030291 0.158471139690512 0.28120142475039 660 482.818181818182 398 0.0155626282945186 155 1.19240585546756 -1.33403223803043 -1 3.36529757900295 660 398 270 324 855 857 558 172 214 155 848 386 M19184 GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. 39/108 Gene Ontology MF GO:0000980 0.264427885969377 0.401068890400802 560 443.636363636364 398 0.0275326628738461 147 0.653874098340854 0.653874098340854 1 1.32894369509959 558 518 147 380 334 238 398 545 504 908 350 387 M18294 GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription. 13/36 Gene Ontology MF GO:0001103 0.0333149008275399 0.119725424848972 870 431.545454545455 399 0.00307548676680883 109 0.516849105422445 -0.293286792445582 -1 2.4404418312664 869 174 312 244 109 399 469 403 359 641 768 388 M18251 GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a monosaccharide from one side of a membrane to the other. 7/25 Gene Ontology MF GO:0015145 0.0409039104975619 0.132505625555482 155 378.363636363636 400 0.00416769211646419 65 0.562263606640544 0.598043814439965 1 2.52801791332272 75 400 698 539 495 153 65 153 707 628 249 389 M18263 GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). 17/47 Gene Ontology MF GO:0016303 0.0512313134980523 0.153028598760416 500 434.636363636364 400 0.00476952176664489 148 0.457595483472063 -0.381868931914989 -1 1.91083005593736 496 266 357 226 148 541 400 603 370 632 742 390 M18853 GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). 4/18 Gene Ontology MF GO:0016775 0.275742742869669 0.415874300721467 620 450.727272727273 400 0.0317460317460317 149 1.42279293755586 -1.42279293755586 -1 2.77697181356504 617 292 829 198 354 560 746 400 308 149 505 391 M18089 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 3/11 Gene Ontology MF GO:0016813 0.214139132665174 0.343818502708482 445 406.727272727273 401 0.0238095238095238 177 0.657787341005868 -0.986493877539723 -1 1.56227245826332 241 367 663 177 520 443 442 401 264 578 378 392 M18371 GO_TRANSCRIPTION_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COFACTOR_BINDING.html Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. 12/34 Gene Ontology MF GO:0001221 0.0241911325665813 0.0994764046641727 570 359.090909090909 402 0.00222375508448101 48 1.31505585488108 1.31505585488108 1 6.75141522400954 568 48 445 147 92 538 402 468 202 299 741 393 M18216 GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of cation from one side of the membrane to the other. 221/681 Gene Ontology MF GO:0008324 0.0839184282471183 0.184260033382694 405 393.272727272727 403 0.00793650793650794 76 1.29511972872285 1.43479475728819 1 4.87308532945789 403 81 105 193 438 842 532 805 149 76 702 394 M18815 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. 20/49 Gene Ontology MF GO:0016684 0.0638334151755259 0.17486683789373 415 435.454545454545 403 0.0059785878815736 130 0.44411971357933 0.469239765398406 1 1.72276204673991 413 130 254 403 161 601 233 735 375 804 681 395 M19145 GO_PROTEIN_PHOSPHATASE_2A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_2A_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. 16/44 Gene Ontology MF GO:0051721 0.0407851269756568 0.132505625555482 555 425.818181818182 403 0.00377831411662461 127 2.24458518468169 2.24458518468169 1 10.0919777158592 555 586 327 253 127 915 524 422 230 342 403 396 M18632 GO_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BINDING.html Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. 22/96 Gene Ontology MF GO:0042562 0.104661745741284 0.213975124626624 580 438.454545454545 404 0.01 15 1.38933387508025 1.38933387508025 1 4.76548894607392 579 15 128 133 404 716 620 802 231 387 808 397 M18774 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. 6/15 Gene Ontology MF GO:0016307 0.0138533906511551 0.0758638059468015 195 404.181818181818 404 0.00139405184669606 49 0.487214809423566 -0.658112359874456 -1 2.79503115773694 195 429 815 404 305 92 250 569 550 788 49 398 M18545 GO_INTERMEDIATE_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BINDING.html Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. 18/27 Gene Ontology MF GO:0019215 0.3086465438689 0.45432771257502 330 478.727272727273 405 0.0329981937511392 195 1.63639951871907 1.63639951871907 1 2.87195271699457 326 819 195 723 641 534 405 232 668 356 367 399 M18206 GO_CATECHOLAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BINDING.html Interacting selectively and non-covalently with catecholamine. 4/17 Gene Ontology MF GO:1901338 0.00860623411468077 0.0546050716241815 275 407 407 0.000863974719588195 50 0.858982002181133 0.858982002181133 1 5.55608502164785 274 330 687 407 254 568 557 50 431 609 310 400 M18268 GO_ALCOHOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BINDING.html Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. 40/136 Gene Ontology MF GO:0043178 0.0490707634792099 0.148993737296611 830 464.090909090909 407 0.004563702585578 139 1.26152223498324 -1.23475542503433 -1 5.34285965316867 848 139 177 221 145 826 828 555 407 175 784 401 M18896 GO_K63_LINKED_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_K63_LINKED_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. 9/19 Gene Ontology MF GO:0070530 0.0765897756730953 0.184260033382694 615 449.727272727273 407 0.00793650793650794 95 1.48034281358945 1.48034281358945 1 5.57001543040837 614 407 842 243 685 566 367 220 95 260 648 402 M18125 GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. 11/36 Gene Ontology MF GO:0005227 0.237853035741744 0.372201027179008 445 419 408 0.0243899899704416 224 1.29994081892301 1.29994081892301 1 2.85803518171927 444 448 229 408 316 777 695 224 314 284 470 403 M18137 GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic hydroxy compound from one side of the membrane to the other. 27/92 Gene Ontology MF GO:1901618 0.00121271237078463 0.015495769182248 235 410.909090909091 409 0.000110307397643708 31 1.25240526293404 1.25240526293404 1 11.61004515161 235 156 31 271 552 527 401 732 622 409 584 404 M17888 GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 46/210 Gene Ontology MF GO:0005244 0.0839184282471183 0.184260033382694 370 410.181818181818 411 0.00793650793650794 71 1.69537640115947 1.76352226706038 1 6.37911209349901 370 773 123 411 633 707 488 272 99 71 565 405 M18099 GO_WNT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_PROTEIN_BINDING.html Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. 18/33 Gene Ontology MF GO:0017147 0.0839184282471183 0.184260033382694 790 460.818181818182 412 0.00793650793650794 65 2.35459573801311 2.35459573801311 1 8.85952537088719 790 71 126 77 826 412 641 857 65 354 850 406 M18657 GO_NADH_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. 26/44 Gene Ontology MF GO:0003954 0.123032195903233 0.2352886341512 85 450.454545454545 413 0.0118640602717113 85 0.564322045552235 -0.564322045552235 -1 1.81645274015891 85 709 599 712 376 118 175 413 808 755 205 407 M19091 GO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_BINDING.html Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. 167/380 Gene Ontology MF GO:0051020 0.0442805737209081 0.139993566402871 905 500 413 0.00410888951512984 133 1.11711023290372 -0.938683725591573 -1 4.8860794207668 904 331 343 443 133 372 782 905 413 311 563 408 M18003 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 49/105 Gene Ontology MF GO:0016651 0.188092556407242 0.314627548899387 375 441.454545454545 414 0.0187643459752838 232 0.564322045552235 -0.564322045552235 -1 1.45167064729422 371 516 557 587 281 232 346 414 677 544 331 409 M18478 GO_DOUBLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA. 317/898 Gene Ontology MF GO:0003690 0.0741508662331546 0.184260033382694 415 490.636363636364 414 0.00697952736078504 174 1.26869666774794 1.37213167494375 1 4.7736645333626 414 750 240 700 174 893 485 366 251 344 780 410 M18637 GO_ISOPRENOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BINDING.html Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 7/53 Gene Ontology MF GO:0019840 0.0765897756730953 0.184260033382694 275 446.727272727273 414 0.00793650793650794 90 0.601566764677045 0.673085334831407 1 2.26348654432231 272 163 786 181 656 870 435 301 90 746 414 411 M18770 GO_TRANSCRIPTION_COACTIVATOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_BINDING.html Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 3/12 Gene Ontology MF GO:0001223 0.33296556889208 0.479387047544153 415 496.909090909091 414 0.0396825396825397 130 1.31505585488108 1.31505585488108 1 2.15091539494137 634 412 813 296 846 472 414 409 353 130 687 412 M19050 GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. 80/201 Gene Ontology MF GO:0005057 0.0839184282471183 0.184260033382694 485 408.636363636364 414 0.00793650793650794 109 1.40396698966403 1.40281440087563 1 5.28263974655745 483 317 414 233 553 869 531 355 138 109 493 413 M18547 GO_AMIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BINDING.html Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 125/369 Gene Ontology MF GO:0033218 0.145826240846626 0.269397874656417 825 512.909090909091 415 0.0142269755119541 103 1.31650292413875 1.52228040098384 1 3.84111969586131 822 374 103 596 403 384 798 710 347 415 690 414 M17853 GO_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently with a polymer of ubiqutin. 25/46 Gene Ontology MF GO:0031593 0.110708331699889 0.221416663399777 415 431.636363636364 416 0.0106096807257776 105 1.48034281358945 1.48034281358945 1 4.96507398645647 415 680 548 477 564 105 416 665 344 402 132 415 M18509 GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 8/22 Gene Ontology MF GO:0099604 0.0250042360135016 0.101787155453192 480 441.454545454545 416 0.00252901190965867 78 1.29994081892301 1.29994081892301 1 6.60740968588635 476 495 756 254 416 874 747 78 132 241 387 416 M18692 GO_N_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. 48/116 Gene Ontology MF GO:0016410 0.116567341812261 0.228660883725545 400 434.272727272727 417 0.0112040537745133 176 2.13321091441245 2.13321091441245 1 7.0020207797691 399 737 580 634 224 176 417 508 384 454 264 417 M18619 GO_OXYGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_BINDING.html Interacting selectively and non-covalently with oxygen (O2). 12/94 Gene Ontology MF GO:0019825 0.0598238345297748 0.168311705710681 505 400.727272727273 419 0.00559230553449676 80 2.01369544572059 2.01369544572059 1 7.98237615136959 349 503 80 366 487 625 419 504 221 302 552 418 M18718 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase. 162/400 Gene Ontology MF GO:0044389 0.144604372273781 0.267678113665751 730 456.454545454545 419 0.0140988663191271 130 1.12050154027372 1.13590817520202 1 3.28521580729672 728 487 348 357 804 130 656 326 419 423 343 419 M17918 GO_LIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of lipids into, out of or within a cell, or between cells. 49/169 Gene Ontology MF GO:0005319 0.313599850201837 0.458155127830397 420 473.090909090909 420 0.0336300934693494 138 1.25523694654677 1.2800765375747 1 2.17957040811134 420 305 138 194 666 812 408 807 452 228 774 420 M17950 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of hydrogen ions from one side of a membrane to the other. 42/114 Gene Ontology MF GO:0015078 0.307015257968116 0.45325910114748 200 394.454545454545 420 0.0327909892421215 196 1.02571973280214 1.13782707616943 1 1.8055561777713 330 199 579 372 494 196 420 622 420 442 265 421 M18024 GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING.html A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors. 16/51 Gene Ontology MF GO:0098531 0.161385165508919 0.28120142475039 705 466.272727272727 420 0.0158730158730159 155 1.31505585488108 1.31505585488108 1 3.71144965570044 704 310 218 155 420 647 645 628 206 337 859 422 M18397 GO_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). 544/1327 Gene Ontology MF GO:0032403 0.0765897756730953 0.184260033382694 320 432.818181818182 420 0.00793650793650794 156 1.34418275095058 1.40694591417714 1 5.05769243207005 318 550 731 420 282 684 477 329 185 156 629 423 M18577 GO_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BINDING.html Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. 29/74 Gene Ontology MF GO:0051287 0.0210384324261889 0.0946672168148218 820 517.363636363636 420 0.00193112334470991 79 1.44075339857929 -1.59008010255122 -1 7.55555784164654 797 420 386 369 79 613 818 819 326 250 814 424 M19066 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. 33/67 Gene Ontology MF GO:0016655 0.224749890783749 0.357733390174826 185 431 420 0.0228769509848785 181 0.564322045552235 -0.564322045552235 -1 1.29048266697407 181 475 585 578 312 202 275 420 531 882 300 425 M18014 GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. 8/15 Gene Ontology MF GO:0010314 0.246599103195592 0.382582082529418 560 457.727272727273 421 0.0279186448771633 218 1.48454799448882 1.48454799448882 1 3.17306213636803 560 290 639 275 421 704 803 218 332 233 560 426 M18469 GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). 4/12 Gene Ontology MF GO:0008556 0.0956179249911956 0.200841303634475 30 392 422 0.01 28 1.38933387508025 1.38933387508025 1 4.96126648328618 422 28 747 29 630 505 539 771 257 147 237 427 M17986 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 12/29 Gene Ontology MF GO:0016894 0.514011397665828 0.660461572419779 405 455.818181818182 423 0.0634920634920635 274 0.38632365312043 -0.347281950686646 -1 0.356494547236126 402 313 423 490 703 274 336 716 445 538 374 428 M18038 GO_ADENYLYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an adenylyl group to an acceptor. 14/34 Gene Ontology MF GO:0070566 0.0285773400763118 0.110891789644148 385 432.454545454545 423 0.00263231321393552 99 0.260699833730765 -0.261109256969319 -1 1.27541472621534 385 423 493 655 99 286 433 358 718 558 349 429 M18247 GO_ICOSANOID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_RECEPTOR_ACTIVITY.html Combining with an icosanoid to initiate a change in cell activity. 4/14 Gene Ontology MF GO:0004953 0.425588848584147 0.574951161082842 190 457.181818181818 424 0.0539321455377196 186 0.57125194902897 0.57125194902897 1 0.703343932560985 186 411 696 512 491 313 216 369 786 625 424 430 M18331 GO_MACROLIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROLIDE_BINDING.html Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. 9/18 Gene Ontology MF GO:0005527 0.0728711502804722 0.184260033382694 300 442.545454545455 425 0.00753772047701241 100 0.262109071246767 -0.239093190925972 -1 0.986225209855456 297 425 716 691 836 138 125 129 754 657 100 431 M18065 GO_PEPTIDE_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for peptide hormones. 8/24 Gene Ontology MF GO:0051428 0.0765897756730953 0.184260033382694 515 390.909090909091 426 0.00793650793650794 89 1.57084733800775 -1.57084733800775 -1 5.91055250430902 515 693 658 259 249 500 467 426 89 235 209 432 M18249 GO_PHOSPHATIDYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BINDING.html Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. 6/28 Gene Ontology MF GO:0031210 0.313303734965277 0.458155127830397 260 422.363636363636 426 0.0368887218618135 183 0.581445231723046 0.633773004562632 1 1.00961075982275 256 329 697 227 388 426 183 524 537 626 453 433 M18712 GO_FK506_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FK506_BINDING.html Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. 9/18 Gene Ontology MF GO:0005528 0.0726786571108796 0.184260033382694 300 460 426 0.00751711661346528 101 0.262109071246767 -0.239093190925972 -1 0.986225209855456 298 426 801 692 837 139 126 114 755 771 101 434 M17927 GO_DNA_BINDING_BENDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BINDING_BENDING.html The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. 9/24 Gene Ontology MF GO:0008301 0.202742872915351 0.332204903709706 395 419.272727272727 427 0.0224030430585947 217 2.33447065204628 2.33447065204628 1 5.72291402265365 392 427 620 217 310 555 436 562 361 255 477 435 M17893 GO_HEAT_SHOCK_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAT_SHOCK_PROTEIN_BINDING.html Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. 58/119 Gene Ontology MF GO:0031072 0.0030313602322646 0.0280567110258632 125 367.818181818182 428 0.000275958653773089 10 1.13975148755868 -1.13975148755868 -1 9.06052140153807 123 745 520 768 428 10 162 131 639 466 54 436 M18904 GO_TETRAPYRROLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BINDING.html Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. 38/185 Gene Ontology MF GO:0046906 0.0243104955344026 0.0994764046641727 430 412.818181818182 428 0.00223485116172621 65 1.27939796113772 1.4500078614896 1 6.56834980459254 428 249 65 262 211 772 706 552 174 433 689 437 M18622 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. 10/17 Gene Ontology MF GO:0016646 0.232850105696956 0.366191619215725 920 543.636363636364 429 0.0238095238095238 220 0.964916235402726 -0.810865129405406 -1 2.15639360689326 920 229 287 220 902 744 842 429 268 271 868 438 M18106 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a lipoprotein particle receptor. 11/30 Gene Ontology MF GO:0070325 0.477765344046408 0.630622835757095 430 484.909090909091 430 0.0573479284991383 252 0.38724146911314 0.375142507766524 1 0.397166965780598 430 545 356 398 409 860 252 308 579 582 615 439 M18204 GO_NADPH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADPH_BINDING.html Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. 9/16 Gene Ontology MF GO:0070402 0.167830451535645 0.289146096278639 435 528 431 0.0182041727519087 277 0.206345341513025 -0.223690622046086 -1 0.569574288358801 431 822 686 820 277 349 424 296 784 608 311 440 M18370 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. 5/13 Gene Ontology MF GO:0016671 0.0890672887406127 0.192804483862032 240 441.454545454545 431 0.0092852480622363 96 0.900436557896745 -0.900436557896745 -1 3.29723264206494 239 655 725 431 728 96 301 248 578 668 187 441 M18915 GO_IRON_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_BINDING.html Interacting selectively and non-covalently with iron (Fe) ions. 55/229 Gene Ontology MF GO:0005506 0.0614539049323852 0.170293953427091 465 473.636363636364 433 0.00574916524921766 81 1.56948643227499 1.93867996149595 1 6.18063313320724 411 433 81 391 463 908 831 463 181 401 647 442 M19156 GO_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. 469/1395 Gene Ontology MF GO:0005215 0.0846180958876913 0.185353924325419 660 499.727272727273 433 0.00800541365141596 89 1.38273648066791 1.54189030207023 1 5.18454955700324 656 402 89 649 433 413 701 896 338 110 810 443 M18217 GO_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 69/193 Gene Ontology MF GO:0016247 0.161385165508919 0.28120142475039 405 451.545454545455 434 0.0158730158730159 244 1.55777379300607 1.57058143644963 1 4.39646652268328 401 533 244 434 472 628 329 657 249 346 674 444 M18934 GO_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVITY.html Catalysis of the hydrolysis of a lipid or phospholipid. 38/132 Gene Ontology MF GO:0016298 0.0839184282471183 0.184260033382694 450 393.272727272727 434 0.00793650793650794 64 1.16930177545582 -0.518091344145802 -1 4.39967609466987 449 377 124 230 513 783 225 458 64 434 669 445 M19194 GO_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. 80/319 Gene Ontology MF GO:0005261 0.0839184282471183 0.184260033382694 575 403.181818181818 434 0.00793650793650794 72 1.34118247067357 1.40444981651651 1 5.04640342002361 268 543 113 387 572 626 434 679 166 72 575 446 M18231 GO_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 370/917 Gene Ontology MF GO:0016301 0.106985605770113 0.216799024908599 490 488 435 0.01023387201132 171 1.18986604846848 1.36487769771965 1 4.0465996608307 857 209 489 489 213 171 913 872 301 419 435 447 M17924 GO_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. 110/237 Gene Ontology MF GO:0042393 0.185002687787592 0.311726140594477 140 435.090909090909 436 0.0184254518624989 137 0.88493116967333 -0.88493116967333 -1 2.2946485540371 137 755 436 823 348 164 521 192 723 520 167 448 M18298 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 76/168 Gene Ontology MF GO:0001076 0.00126734031511334 0.015971960135675 660 443 436 0.000115279179391022 15 1.10597326277692 1.21032960265383 1 10.1781235008523 657 35 370 56 15 658 728 878 121 436 919 449 M18475 GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES.html Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance. 52/130 Gene Ontology MF GO:0043492 0.415767470372913 0.565001584554032 465 424.363636363636 436 0.0476852273427728 241 1.13231995638128 -0.916099069114754 -1 1.43812096171052 463 584 353 488 661 241 576 314 436 253 299 450 M18708 GO_PEPTIDE_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_BINDING.html Interacting selectively and non-covalently with any peptide with hormonal activity in animals. 11/55 Gene Ontology MF GO:0017046 0.0944918444982369 0.200305292484742 770 475.545454545455 436 0.00898295500454293 197 0.387337851801506 0.439746044289792 1 1.38547357998365 301 436 255 451 197 422 391 731 768 770 509 451 M18005 GO_CORE_PROMOTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. 95/242 Gene Ontology MF GO:0001047 0.139457298873253 0.262304503468972 680 474.090909090909 437 0.0135610312729867 176 1.21869441962302 1.27043647930126 1 3.62808719509802 678 525 176 309 247 753 590 437 389 222 889 452 M18822 GO_GTPASE_ACTIVATING_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVATING_PROTEIN_BINDING.html Interacting selectively and non-covalently with a GTPase activating protein. 13/36 Gene Ontology MF GO:0032794 0.0217611560243162 0.0955441186902575 535 444.181818181818 438 0.00199813034885178 68 0.385324298106339 0.437682671006494 1 2.01280307237944 532 216 377 315 175 833 438 68 518 808 606 453 M18191 GO_CATION_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). 8/28 Gene Ontology MF GO:0015491 0.513081667148894 0.660461572419779 240 478.272727272727 439 0.0694373599176752 238 1.08023697533246 -1.08023697533246 -1 0.996829173557056 418 257 684 326 891 757 239 439 501 238 511 454 M17890 GO_PROTEIN_KINASE_C_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_BINDING.html Interacting selectively and non-covalently with protein kinase C. 41/75 Gene Ontology MF GO:0005080 0.033698958259586 0.1201668279024 460 401.727272727273 440 0.00311149975679648 111 0.936415724679591 0.936415724679591 1 4.41387247682256 459 138 188 117 111 761 786 323 584 440 512 455 M18035 GO_GUANYLATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYLATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + GMP = ADP + GDP. 7/16 Gene Ontology MF GO:0004385 0.0821772523966761 0.184260033382694 440 441.272727272727 440 0.00853843794321531 190 0.282091233455602 -0.283552234651216 -1 1.06141114218912 440 573 645 373 190 210 381 510 759 555 218 456 M18131 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol phosphate. 75/175 Gene Ontology MF GO:1901981 0.35943518917414 0.504855532885815 755 493.909090909091 441 0.0396825396825397 226 1.43420149456685 1.65754828936556 1 2.18063886191318 752 441 226 388 667 378 597 686 394 370 534 457 M18999 GO_PROTEIN_N_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 62/154 Gene Ontology MF GO:0047485 0.0576025730603793 0.1660008141507 445 465.181818181818 442 0.00537895374288331 71 0.567661599715564 -0.481449101090274 -1 2.26769331283941 442 246 570 418 879 71 440 579 480 861 131 458 M18091 GO_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. 283/710 Gene Ontology MF GO:0004672 0.0839184282471183 0.184260033382694 330 485.363636363636 444 0.00793650793650794 186 1.2562329625413 1.44443875475912 1 4.72676794196776 696 258 444 501 328 374 752 749 186 328 723 459 M18189 GO_CLATHRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_BINDING.html Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. 29/71 Gene Ontology MF GO:0030276 0.35943518917414 0.504855532885815 445 492.818181818182 444 0.0396825396825397 249 1.46162622607962 -1.01405746558881 -1 2.22233693526772 712 326 264 444 408 444 753 876 362 249 583 460 M18041 GO_ANKYRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANKYRIN_BINDING.html Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. 12/49 Gene Ontology MF GO:0030506 0.0233344887140237 0.0994764046641727 90 332.818181818182 445 0.00214415697006564 88 1.21394280040371 1.21394280040371 1 6.23230706076079 101 610 225 464 88 506 571 90 449 112 445 461 M18406 GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 434/1422 Gene Ontology MF GO:0001071 0.0313781091605968 0.116402663015117 105 465.090909090909 446 0.00289407214602669 102 1.21882396513444 1.39599653492968 1 5.83131756181653 446 524 102 640 104 854 503 365 418 308 852 462 M18135 GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. 18/45 Gene Ontology MF GO:0015662 0.373132320400989 0.521704764086489 860 479.636363636364 448 0.0415676952864504 144 1.2100134836211 -1.03069309216194 -1 1.75140188976068 860 236 152 288 784 556 763 431 448 144 614 463 M18232 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 44/118 Gene Ontology MF GO:0003705 0.0701999580303154 0.184260033382694 485 396.181818181818 448 0.00659504068100697 169 0.881230065715539 0.881230065715539 1 3.31576235953873 248 568 209 485 169 484 480 241 599 448 427 464 M18429 GO_RAB_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GTPASE_BINDING.html Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. 66/135 Gene Ontology MF GO:0017137 0.35943518917414 0.504855532885815 905 529 449 0.0396825396825397 259 1.27270538620535 -1.12330469101083 -1 1.93509127761706 903 259 449 393 439 487 821 660 376 329 703 465 M18776 GO_NEUREXIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUREXIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. 9/14 Gene Ontology MF GO:0042043 0.0357596307915475 0.123967534382894 820 471.727272727273 449 0.0036348448797213 63 0.406948523278571 -0.316117223264884 -1 1.88999582670361 381 546 816 449 818 143 63 790 279 789 115 466 M18486 GO_SCAFFOLD_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAFFOLD_PROTEIN_BINDING.html Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. 34/84 Gene Ontology MF GO:0097110 0.35943518917414 0.504855532885815 635 560.727272727273 451 0.0396825396825397 286 1.24795994876036 -1.42279293755586 -1 1.8974669506372 633 286 316 415 451 836 807 850 392 294 888 467 M18571 GO_FERROUS_IRON_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERROUS_IRON_BINDING.html Interacting selectively and non-covalently with ferrous iron, Fe(II). 15/29 Gene Ontology MF GO:0008198 0.0291218267090181 0.11200037664264 650 434.545454545455 451 0.00268314697853027 52 0.831099373833084 -0.831099373833084 -1 4.04757414292447 646 580 451 465 756 193 52 324 305 724 284 468 M17935 GO_BHLH_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BHLH_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. 16/36 Gene Ontology MF GO:0043425 0.0053662829652544 0.0404377573904366 720 465.818181818182 452 0.000489037943838653 20 0.501206766332241 -0.355273577159823 -1 3.57681111306425 716 20 303 67 36 878 792 452 427 524 909 469 M18396 GO_CARBON_CARBON_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_CARBON_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 20/54 Gene Ontology MF GO:0016830 0.0895406537464438 0.193374181799832 455 465.818181818182 453 0.00849156225221579 110 1.23889395501682 -1.23889395501682 -1 4.52846984765232 453 643 301 651 816 211 342 516 708 373 110 470 M18408 GO_ADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_BINDING.html Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. 26/67 Gene Ontology MF GO:0043531 0.43595219542415 0.584658920976994 635 454.818181818182 453 0.0507243174882087 166 1.01908102972233 1.01908102972233 1 1.21676786628451 631 557 166 441 453 244 368 656 485 405 597 471 M17994 GO_CYCLIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_BINDING.html Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. 8/22 Gene Ontology MF GO:0030332 0.0535435238706 0.157301636349229 270 463.181818181818 454 0.00548791541142776 72 1.05077947290469 1.05077947290469 1 4.32347508646016 270 589 632 598 919 269 72 880 454 231 181 472 M18557 GO_SUMO_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. 10/17 Gene Ontology MF GO:0019789 0.478970633195652 0.63130799790831 310 505.818181818182 454 0.0575459171670425 281 0.341372054915465 0.348465236556377 1 0.349297208137119 307 364 411 450 820 462 454 590 705 720 281 473 M17939 GO_METHYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 28/67 Gene Ontology MF GO:0035064 0.0463084963910997 0.144419717558684 130 436 455 0.00430118070395705 65 0.88493116967333 -0.88493116967333 -1 3.80928467121965 129 852 492 803 455 65 445 165 782 526 82 474 M17971 GO_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for hormones. 89/307 Gene Ontology MF GO:0051427 0.0938729185443518 0.19945285233442 895 501.636363636364 455 0.00892139482533523 104 1.31620853297742 1.23132893130065 1 4.72045028622725 891 167 421 104 196 531 860 852 455 407 634 475 M18470 GO_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 24/81 Gene Ontology MF GO:0003777 0.358797675763924 0.504855532885815 395 564.909090909091 455 0.0395956932464081 213 0.862559895960135 -0.862559895960135 -1 1.31148346835501 393 838 232 885 878 213 430 455 815 695 380 476 M18235 GO_ANTIOXIDANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIOXIDANT_ACTIVITY.html Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. 31/82 Gene Ontology MF GO:0016209 0.426688215057723 0.575591140547076 365 451.727272727273 456 0.0493174255804299 203 0.428652160846481 0.474047089738022 1 0.526709585710585 365 262 203 548 456 598 207 594 437 620 679 477 M18335 GO_O_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. 11/20 Gene Ontology MF GO:0008171 0.0063947837850855 0.0445697051687777 165 344.454545454545 456 0.000583040693224219 29 0.274679980108446 -0.364749004367965 -1 1.90077688348146 165 509 474 456 716 40 35 146 561 658 29 478 M18596 GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING.html Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. 46/115 Gene Ontology MF GO:0008135 0.257667296366992 0.394432466984414 385 475.636363636364 456 0.0267235034617307 223 0.249059304007819 -0.286893868779211 -1 0.515436311672489 383 551 606 660 327 223 456 312 644 732 338 479 M18659 GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). 13/28 Gene Ontology MF GO:0036442 0.342940485860138 0.489914979800198 355 468.636363636364 457 0.0374603913379238 257 0.801505046067566 -0.801505046067566 -1 1.27221453285965 355 478 475 457 365 341 648 441 582 756 257 480 M18977 GO_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 35/126 Gene Ontology MF GO:0005267 0.255875955153591 0.392343131235506 380 425.909090909091 460 0.0265102248144795 130 1.42077848641286 1.41977126084137 1 2.95713435525767 378 591 130 460 614 603 231 567 379 141 591 481 M18150 GO_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to an acceptor molecule. 51/114 Gene Ontology MF GO:0016407 0.0974606133407529 0.203511591819799 465 436.545454545455 464 0.00927877023921134 201 1.70498545690517 -1.27675999939789 -1 6.03835243568878 464 605 565 475 201 305 619 496 286 384 402 482 M18376 GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS.html Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). 12/20 Gene Ontology MF GO:0016780 0.0712546998840107 0.184260033382694 465 450 464 0.00669753842204411 110 0.312059139160216 -0.427031959865831 -1 1.17416995712319 527 558 462 672 464 414 512 110 341 671 219 483 M19090 GO_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. 196/476 Gene Ontology MF GO:0016887 0.141461519001363 0.263984984748993 880 499.727272727273 464 0.0137701104257734 127 1.00462285678148 -0.832663863348321 -1 2.9765180213626 189 879 431 879 890 127 464 295 617 484 242 484 M18779 GO_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBULIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. 151/374 Gene Ontology MF GO:0015631 0.0416470127569974 0.133969411665866 470 435.545454545455 466 0.00385972351770209 73 1.14935080568596 -0.860199414465816 -1 5.13955626350276 466 780 319 787 131 73 453 538 560 469 215 485 M18225 GO_GDP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_BINDING.html Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. 42/79 Gene Ontology MF GO:0019003 0.581531783512318 0.723963790028867 455 502.909090909091 467 0.0761410300626452 283 0.815114882531196 0.815114882531196 1 0.585714321736905 323 467 482 454 454 712 283 770 546 443 598 486 M18430 GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. 13/28 Gene Ontology MF GO:0003950 0.0361036828614347 0.123967534382894 795 469.818181818182 468 0.0033372865649456 118 0.342485925083249 0.281608962718358 1 1.59061139954123 793 183 473 332 118 468 564 799 383 685 370 487 M18419 GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. 11/23 Gene Ontology MF GO:0070003 0.326220982646842 0.47487864562515 370 492.818181818182 469 0.0352591234266006 228 0.23844785528811 -0.242108546813732 -1 0.395019189490219 366 228 584 463 359 311 698 491 771 681 469 488 M18706 GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a substance from one side of a membrane to the other. 347/1090 Gene Ontology MF GO:0022857 0.0397807102639079 0.131176535637259 470 457.454545454545 469 0.00368352582163653 71 1.37372372543392 1.53405723179698 1 6.20726655523471 469 390 71 469 492 717 527 828 176 84 809 489 M18022 GO_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_ACTIVITY.html The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. 2/12 Gene Ontology MF GO:0009881 0.0597313717204524 0.168311705710681 550 405 470 0.00681993460906753 83 0.369425353309847 -0.614346367604407 -1 1.46441802196353 550 464 640 NA 476 382 83 164 588 552 151 490 M18039 GO_ATPASE_ACTIVITY_COUPLED http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. 153/347 Gene Ontology MF GO:0042623 0.070880839359681 0.184260033382694 470 478.363636363636 470 0.00666119528961729 81 1.03303544894575 -0.822698519144383 -1 3.88695326231229 199 865 470 852 882 81 349 280 638 470 176 491 M17972 GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 56/188 Gene Ontology MF GO:0072509 0.172033908227682 0.29418437838191 290 474.272727272727 472 0.0170156680208484 109 1.27680313775007 1.37508621895887 1 3.47528998062509 288 781 109 790 321 672 585 526 391 282 472 492 M19071 GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 164/384 Gene Ontology MF GO:0003713 0.0905612630803908 0.193516954120293 465 424.181818181818 472 0.0085926559535335 93 0.924166543064818 -0.698668022769986 -1 3.37654441442829 462 542 538 600 232 93 643 472 395 489 200 493 M18237 GO_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_ACTIVITY.html The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. 25/137 Gene Ontology MF GO:0005179 0.159720258253906 0.28120142475039 265 478.909090909091 473 0.0156955583702942 192 0.44565232201799 0.421217631273052 1 1.25775344838098 328 575 192 642 261 473 263 920 469 621 524 494 M18790 GO_SIALYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. 6/21 Gene Ontology MF GO:0008373 0.262575873105072 0.399510263186311 360 493.181818181818 473 0.03 65 0.703777757316276 0.758249218170523 1 1.43646473403817 358 65 818 419 569 678 386 473 498 793 368 495 M18714 GO_STEROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a steroid hormone receptor. 46/118 Gene Ontology MF GO:0035258 0.113724251322089 0.225974754246916 675 519 475 0.0109151875537136 110 1.23132893130065 1.23132893130065 1 4.07406448700595 672 248 392 110 219 779 696 889 475 362 867 496 M18040 GO_S_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. 17/29 Gene Ontology MF GO:0016417 0.0410614721755038 0.132549313689345 305 452.272727272727 476 0.00380440905081208 80 0.331467209184328 -0.330358780111214 -1 1.49008103514343 302 621 460 761 705 148 352 476 511 559 80 497 M18665 GO_WIDE_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WIDE_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. 13/27 Gene Ontology MF GO:0022829 0.486283726404838 0.637294912097509 285 500.090909090909 476 0.0587562177299185 171 0.475593809449117 0.50057534607535 1 0.476649029262998 283 530 171 726 584 476 371 453 733 757 417 498 M18498 GO_CALMODULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_BINDING.html Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. 71/244 Gene Ontology MF GO:0005516 0.0270751121555049 0.107831615511102 335 413.545454545455 477 0.00249219805375776 76 1.4346431750322 1.47299736167272 1 7.10797630349577 332 526 92 439 588 790 515 76 477 132 582 499 M18993 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the tumor necrosis factor receptor. 12/34 Gene Ontology MF GO:0005164 0.35943518917414 0.504855532885815 560 537.090909090909 477 0.0396825396825397 238 0.39397361652018 0.3517602004634 1 0.599019062133954 559 238 391 430 477 913 312 738 372 860 618 500 M18182 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS.html Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. 19/47 Gene Ontology MF GO:0016706 0.232850105696956 0.366191619215725 890 540.272727272727 479 0.0238095238095238 277 1.8636644772713 1.8636644772713 1 4.16491519329476 886 579 393 473 734 297 559 479 277 365 901 501 M18348 GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. 163/410 Gene Ontology MF GO:0042578 0.383995302516273 0.531241621526273 475 552.818181818182 479 0.0430895994431622 354 1.24590925237217 1.3057184655566 1 1.75315023617796 473 617 399 685 380 840 354 639 479 456 759 502 M18372 GO_HSP90_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP90_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. 16/38 Gene Ontology MF GO:0051879 0.158586786074828 0.28120142475039 260 421.363636363636 479 0.0155749277414056 163 0.254663724065473 -0.286441551827729 -1 0.718731025854027 479 645 527 591 259 190 163 257 656 669 199 503 M18903 GO_ZINC_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_BINDING.html Interacting selectively and non-covalently with zinc (Zn) ions. 477/1372 Gene Ontology MF GO:0008270 0.102476397172206 0.210913390153085 910 563.727272727273 479 0.00978057064033807 199 1.15299688243053 1.40108767884998 1 3.99180663008399 908 817 458 897 209 199 797 723 349 479 365 504 M19063 GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. 8/20 Gene Ontology MF GO:0004198 0.221649349936629 0.354023267259893 425 503.727272727273 479 0.0247464738178561 183 0.406989017464699 -0.389380358026881 -1 0.940134819568613 421 479 885 652 619 183 256 240 735 880 191 505 M17871 GO_MHC_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the major histocompatibility complex. 15/33 Gene Ontology MF GO:0023023 0.262721423073607 0.399510263186311 190 541.636363636364 480 0.027327784367445 189 1.17118196214672 1.17118196214672 1 2.39047289180938 873 454 189 189 332 726 849 480 672 331 863 506 M18760 GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 307/779 Gene Ontology MF GO:0000988 0.0459816706802532 0.143888221176302 855 489.909090909091 482 0.00427016540533285 139 1.14800403208584 1.28635950490978 1 4.9511270530122 851 223 509 498 139 336 748 884 254 482 465 507 M17849 GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. 7/25 Gene Ontology MF GO:0004112 0.325645793803491 0.474792599523315 555 472.090909090909 483 0.0386338928296039 187 0.402339418381743 0.514974265481419 1 0.666688687968865 553 371 608 483 394 547 187 454 464 495 637 508 M18505 GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the class II major histocompatibility complex. 15/28 Gene Ontology MF GO:0023026 0.262721423073607 0.399510263186311 190 543 483 0.027327784367445 190 1.17118196214672 1.17118196214672 1 2.39047289180938 874 455 190 190 333 727 850 483 673 334 864 509 M18110 GO_RHO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GTPASE_BINDING.html Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. 51/106 Gene Ontology MF GO:0017048 0.0307950650364887 0.116112540301515 650 502.181818181818 484 0.00283952438112536 102 1.02942879963212 -0.838850138406758 -1 4.93089383484217 648 497 367 484 102 787 427 492 435 383 902 510 M18710 GO_KINESIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_BINDING.html Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. 24/60 Gene Ontology MF GO:0019894 0.11776065692122 0.229533483829496 450 563.727272727273 487 0.0113255499144354 97 1.90919498657043 1.90919498657043 1 6.25053732460933 448 913 97 884 353 730 644 823 424 398 487 511 M18128 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 15/37 Gene Ontology MF GO:0016893 0.597318307603006 0.737627977174182 525 467.272727272727 488 0.0793650793650794 237 0.30186196075694 -0.335683236027436 -1 0.204351735364156 499 237 522 385 523 355 473 652 488 588 418 512 M19102 GO_ADENYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. 664/1625 Gene Ontology MF GO:0030554 0.0210537506930699 0.0946672168148218 490 499.454545454545 488 0.00212559188611668 47 1.10844331713357 1.32348167754274 1 5.81286676739046 432 836 892 887 207 47 506 487 564 488 148 513 M19169 GO_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. 43/97 Gene Ontology MF GO:0008080 0.181850529626598 0.308107711337882 490 493.545454545455 489 0.0180809273515149 276 2.13321091441245 2.13321091441245 1 5.5868755411146 490 730 572 647 276 317 624 489 409 445 430 514 M18250 GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY.html Functions in chain elongation during polypeptide synthesis at the ribosome. 11/20 Gene Ontology MF GO:0003746 0.0404115244118913 0.131839015811844 125 382.909090909091 490 0.00374304615377407 62 0.294771257040014 -0.337471685399002 -1 1.3286410531741 125 593 490 606 529 62 156 126 775 627 123 515 M18363 GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. 10/70 Gene Ontology MF GO:0030594 0.0839184282471183 0.184260033382694 605 491.636363636364 490 0.00793650793650794 63 0.515387001377086 -0.404921429779867 -1 1.93922204359992 603 63 288 241 914 824 460 490 141 666 718 516 M17872 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. 11/30 Gene Ontology MF GO:0035255 0.271372316318429 0.410629162850254 435 494.272727272727 491 0.0283708956406608 219 0.858982002181133 0.858982002181133 1 1.70079332109311 434 491 311 374 344 819 826 219 602 504 513 517 M18228 GO_S100_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_S100_PROTEIN_BINDING.html Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. 9/20 Gene Ontology MF GO:0044548 0.0903600497716526 0.193516954120293 495 505.272727272727 492 0.00942593639906202 204 0.504144242350307 -0.607344542527598 -1 1.84194654088668 562 458 693 492 204 492 883 284 553 619 318 518 M18906 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. 9/30 Gene Ontology MF GO:0031435 0.44804903739675 0.600007444548778 665 548.272727272727 492 0.0576981375253039 243 0.188584516131952 -0.242524205254416 -1 0.214295862314859 492 665 846 665 411 295 243 419 714 835 446 519 M18771 GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY.html Modulation of the activity of the enzyme protein phosphatase type 2A. 9/22 Gene Ontology MF GO:0008601 0.5170238298381 0.662481787536285 815 579.545454545455 493 0.0701935161499687 327 0.237169805454142 -0.22231057234029 -1 0.217245864562878 814 493 814 479 444 438 327 399 686 786 695 520 M18512 GO_OMEGA_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OMEGA_PEPTIDASE_ACTIVITY.html Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). 10/15 Gene Ontology MF GO:0008242 0.203127902730693 0.332204903709706 880 525.090909090909 495 0.0204303315387855 274 0.874649861425705 -0.874649861425705 -1 2.14418876913222 879 321 419 495 294 760 626 274 456 705 547 521 M18780 GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. 12/29 Gene Ontology MF GO:0015605 0.0441113995394007 0.139939612331892 395 481.363636363636 496 0.00409286488921351 94 0.264705316675566 -0.314707682982354 -1 1.15800985225175 394 670 496 662 813 228 322 94 615 790 211 522 M19033 GO_MISFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with a misfolded protein. 11/19 Gene Ontology MF GO:0051787 0.122728379965356 0.2352886341512 625 511.636363636364 496 0.0118329443597636 116 0.322354789474047 -0.311250885594292 -1 1.03760292838293 624 328 402 219 911 116 496 572 796 869 295 523 M19150 GO_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOMERASE_ACTIVITY.html Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. 75/174 Gene Ontology MF GO:0016853 0.330148814076809 0.478325840867187 435 537.545454545455 496 0.0357717568283829 205 1.07493240615649 -0.649760706663241 -1 1.76346696499342 618 845 412 785 603 205 487 595 496 435 432 524 M17917 GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 87/194 Gene Ontology MF GO:0008234 0.053679270307592 0.157301636349229 770 522.363636363636 497 0.00500323551780747 151 1.38489941543183 1.38489941543183 1 5.6982252896086 767 474 324 615 151 648 370 777 497 310 813 525 M18846 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. 12/25 Gene Ontology MF GO:0015215 0.036193805277257 0.123967534382894 815 483.818181818182 497 0.00334575838041757 87 0.264705316675566 -0.314707682982354 -1 1.22937397591276 395 671 497 663 814 229 323 87 616 815 212 526 M19120 GO_SEMAPHORIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with semaphorin receptors. 10/29 Gene Ontology MF GO:0030215 0.711404610674561 0.829521219037511 225 504.454545454545 497 0.106827385059367 210 1.1712352121029 1.1712352121029 1 0.486983805431349 222 457 210 497 744 654 363 856 700 277 569 527 M18893 GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. 7/18 Gene Ontology MF GO:0042975 0.118348373799909 0.230191340160499 510 532.272727272727 498 0.0125168328373351 244 0.358573098971585 -0.269415564279365 -1 1.17165393608198 509 417 841 359 244 430 404 669 654 830 498 528 M17910 GO_VITAMIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 12/33 Gene Ontology MF GO:0051183 0.162306629973314 0.28227239995359 315 439.636363636364 499 0.0159713697565035 107 0.516943563827261 0.439962407547724 1 1.45458551955672 313 559 107 499 663 580 463 331 282 516 523 529 M18927 GO_RETINOL_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. 9/32 Gene Ontology MF GO:0004745 0.147859119791321 0.270976872924334 350 483.181818181818 499 0.0158730158730159 241 1.02401096892853 1.02401096892853 1 2.97441220318259 348 449 854 553 722 499 258 611 241 261 519 530 M17862 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase. 18/31 Gene Ontology MF GO:0051019 0.393555083549044 0.540553840032558 820 533.454545454545 500 0.0444492449600509 271 0.235036937376578 0.303261484717851 1 0.321640450147201 373 820 439 817 436 515 335 271 790 500 572 531 M17933 GO_STEROID_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_DEHYDROGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. 14/53 Gene Ontology MF GO:0016229 0.597318307603006 0.737627977174182 765 564.272727272727 500 0.0793650793650794 341 0.50491279453589 -0.50491279453589 -1 0.341811315779127 765 446 422 500 571 804 341 456 495 523 884 532 M18283 GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES.html Catalysis of the hydrolysis of any acid anhydride. 387/890 Gene Ontology MF GO:0016817 0.140954429207185 0.263984984748993 385 521.090909090909 501 0.0137171691977542 126 1.08759215893067 1.26660439731591 1 3.22234125037891 384 904 501 892 714 126 556 386 523 476 270 533 M18495 GO_GLYCOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BINDING.html Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. 13/28 Gene Ontology MF GO:0051861 0.123645889100329 0.235515979238722 540 443.363636363636 501 0.0119269427793886 99 0.946863186450032 -0.946863186450032 -1 3.04575076299411 537 122 99 136 768 158 501 841 625 702 388 534 M19200 GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a calcium channel. 18/62 Gene Ontology MF GO:0005246 0.161385165508919 0.28120142475039 800 538.727272727273 501 0.0158730158730159 237 1.51935086267539 -1.51935086267539 -1 4.28802643144506 800 620 380 412 501 810 780 551 237 359 476 535 M18269 GO_L_ASCORBIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_BINDING.html Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 13/21 Gene Ontology MF GO:0031418 0.161385165508919 0.28120142475039 675 463.818181818182 502 0.0158730158730159 228 1.8636644772713 1.8636644772713 1 5.25977427732769 673 502 236 345 336 728 567 523 228 313 651 536 M18548 GO_LIPOPOLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with lipopolysaccharide. 11/32 Gene Ontology MF GO:0001530 0.199940514481756 0.329061311848329 400 496.272727272727 502 0.0200747815424938 163 1.29644110978073 1.29644110978073 1 3.20562357683335 397 717 163 522 393 919 778 193 587 288 502 537 M17869 GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. 9/21 Gene Ontology MF GO:0034237 0.428264177987737 0.576871220715547 205 522.727272727273 503 0.0543737044476118 203 0.216859596460682 0.242766691961729 1 0.265396121131729 203 742 611 661 426 445 217 711 822 503 409 538 M18214 GO_NEUROPEPTIDE_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_HORMONE_ACTIVITY.html The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. 8/29 Gene Ontology MF GO:0005184 0.386086746459241 0.532533443392056 475 507.818181818182 504 0.0476190476190476 229 0.611972872105807 0.356831695128744 1 0.857815901512441 584 471 690 616 471 504 229 364 398 614 645 539 M19003 GO_GLUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 10/16 Gene Ontology MF GO:0046527 0.141449532170209 0.263984984748993 600 451 504 0.013768858647696 157 0.256743124774338 -0.235761207754637 -1 0.760683901084365 599 389 533 504 618 206 181 157 515 863 396 540 M17878 GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. 14/37 Gene Ontology MF GO:0008376 0.0165299801816732 0.0826499009083662 570 474.818181818182 505 0.00151413660686724 68 0.792818209239797 -0.951227257522007 -1 4.39710126528386 721 252 310 329 68 535 899 568 468 505 568 541 M18054 GO_NUCLEOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_BINDING.html Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. 35/80 Gene Ontology MF GO:0031491 0.376653037416082 0.525031506701205 545 495.909090909091 505 0.0420583040050746 263 1.33403223803043 -1.33403223803043 -1 1.91204591197047 541 679 271 689 635 280 699 263 505 429 464 542 M18587 GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any complex of RNA and protein. 64/123 Gene Ontology MF GO:0043021 0.378933972014737 0.527411882380572 280 496.181818181818 506 0.0423774965987743 221 1.35593454827845 1.35593454827845 1 1.92979348460385 279 595 571 621 441 221 616 506 704 467 437 543 M18704 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 14/38 Gene Ontology MF GO:0097472 0.597318307603006 0.737627977174182 605 531.545454545455 506 0.0793650793650794 348 0.631262575792853 -0.631262575792853 -1 0.427346487410153 605 599 417 625 506 348 618 410 494 769 456 544 M19190 GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. 64/150 Gene Ontology MF GO:0001046 0.185806735909705 0.312508586904806 835 494.454545454545 506 0.0185135265887977 182 1.28309967943182 1.42952063866083 1 3.3199539229501 833 632 238 506 280 614 660 465 421 182 608 545 M18537 GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. 125/394 Gene Ontology MF GO:0022804 0.0808381805778206 0.184260033382694 665 468.636363636364 507 0.0076337221937991 87 1.38472669216927 1.70292176674753 1 5.21024519333533 663 277 87 272 507 522 775 888 167 120 877 546 M18885 GO_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_BINDING.html Interacting selectively and non-covalently with any enzyme. 957/2452 Gene Ontology MF GO:0019899 0.206406183167608 0.335501216456183 435 518.272727272727 508 0.0228531697982384 265 1.28122904846874 1.36793481022642 1 3.11276893688534 433 465 839 641 311 544 508 559 343 265 793 547 M18858 GO_GTP_RHO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_RHO_BINDING.html Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. 12/21 Gene Ontology MF GO:0017049 0.670885645251387 0.798466744671768 510 524.636363636364 509 0.0960957286377113 280 0.343286547019628 0.368009138147163 1 0.171871726261587 419 456 409 509 625 509 280 395 726 818 625 548 M18490 GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 3/12 Gene Ontology MF GO:0015129 0.382970073798199 0.530720399355332 455 519.545454545455 510 0.04713665042246 279 0.458023024380104 -0.652106835360889 -1 0.645495803911622 455 549 752 510 723 401 293 279 569 700 484 549 M17892 GO_PROTEIN_COMPLEX_SCAFFOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SCAFFOLD.html Functions to provide a physical support for the assembly of a multiprotein complex. 34/90 Gene Ontology MF GO:0032947 0.358774774235134 0.504855532885815 670 512.636363636364 511 0.039592574904367 371 0.77462355565514 -0.644872453133905 -1 1.17778020978856 668 443 529 452 371 406 707 518 618 511 416 550 M18049 GO_POLY_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_BINDING.html Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. 9/22 Gene Ontology MF GO:0008143 0.375894415907973 0.524769139052102 515 521.181818181818 511 0.0460495727793543 236 0.311449973974621 -0.317030707618857 -1 0.44674220151512 511 484 651 599 398 236 475 836 535 564 444 551 M19052 GO_GAP_JUNCTION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION_CHANNEL_ACTIVITY.html A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. 9/19 Gene Ontology MF GO:0005243 0.725106464704047 0.841233225129537 880 559.090909090909 511 0.121146568736277 206 0.522954326884528 0.506489938866332 1 0.201126848125554 206 571 879 511 785 388 330 415 729 876 460 552 M18119 GO_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. 45/90 Gene Ontology MF GO:0008170 0.0533803561873244 0.157301636349229 195 477.181818181818 513 0.00497466785481386 67 0.25442769831569 -0.257443989405221 -1 1.04685305781563 191 793 582 853 910 67 313 343 513 586 98 553 M18533 GO_GLUCOCORTICOID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glucocorticoid receptor. 9/19 Gene Ontology MF GO:0035259 0.00332355143064003 0.0296860904484352 680 482.818181818182 514 0.000332853261616707 33 0.904374658176375 0.904374658176375 1 7.07580934967878 677 195 764 228 33 706 224 475 514 713 782 554 M18874 GO_RAC_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GTPASE_BINDING.html Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. 29/56 Gene Ontology MF GO:0048365 0.0552819810686844 0.159935291142106 400 476 516 0.00515654899965639 153 0.917079885292811 -0.82699525963007 -1 3.73948852004315 398 689 379 536 153 576 170 694 516 417 708 555 M18965 GO_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. 52/315 Gene Ontology MF GO:0003823 0.32989491530408 0.478325840867187 520 489.090909090909 516 0.0357385372113693 141 1.17118196214672 1.17118196214672 1 1.9213679872235 516 678 141 620 375 258 580 575 703 463 471 556 M18252 GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS.html Catalysis of the hydrolysis of any ester bond. 329/826 Gene Ontology MF GO:0016788 0.0759704683643289 0.184260033382694 785 513 518 0.00715710570873674 84 1.06068080148009 1.21995386618029 1 3.9909731167837 783 541 518 574 283 84 852 794 438 478 298 557 M18351 GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. 17/37 Gene Ontology MF GO:0051119 0.217123478987025 0.348002788620318 295 530.181818181818 518 0.0220069879506247 272 0.717301207645577 -0.717301207645577 -1 1.68431804404091 791 272 294 423 306 293 772 858 642 663 518 558 M19177 GO_STRUCTURAL_MOLECULE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_MOLECULE_ACTIVITY.html The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. 349/949 Gene Ontology MF GO:0005198 0.0839184282471183 0.184260033382694 505 464.181818181818 518 0.00793650793650794 164 1.39498468271997 1.50175361911917 1 5.24884244699406 504 537 314 518 269 570 600 606 164 223 801 559 M18195 GO_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). 19/84 Gene Ontology MF GO:0015297 0.557443745451391 0.697752715394939 815 560.090909090909 519 0.0714285714285714 286 1.08023697533246 -1.08023697533246 -1 0.864839027756612 813 477 286 414 519 528 647 780 471 366 860 560 M19007 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. 5/10 Gene Ontology MF GO:0046933 0.632427457617131 0.762559975108467 870 532.181818181818 520 0.0952380952380952 357 0.242081430462985 -0.290872937531906 -1 0.145980560448056 409 481 869 529 548 357 541 370 520 866 364 561 M18081 GO_ADRENERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_ACTIVITY.html Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. 4/26 Gene Ontology MF GO:0004935 0.0814472600579536 0.184260033382694 325 499.181818181818 521 0.00845961003912114 128 0.858982002181133 0.858982002181133 1 3.23205062794677 321 473 661 521 795 651 533 128 470 576 362 562 M18681 GO_GLUTATHIONE_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_TRANSFERASE_ACTIVITY.html Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. 16/38 Gene Ontology MF GO:0004364 0.0839184282471183 0.184260033382694 715 469.636363636364 521 0.00793650793650794 44 2.76431492756404 2.76431492756404 1 10.4011562984831 714 501 170 282 611 521 708 632 44 340 643 563 M17894 GO_PHOSPHOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_BINDING.html Interacting selectively and non-covalently with a phosphorylated protein. 40/84 Gene Ontology MF GO:0051219 0.660173763128577 0.789804762130417 850 600.272727272727 522 0.0934599584649138 330 1.17458438897892 1.51518007508918 1 0.616574998112028 849 688 388 397 480 489 762 854 522 330 844 564 M18385 GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. 2/8 Gene Ontology MF GO:0003964 0.222483639620813 0.354739945322613 520 549.1 522 0.0275738814174418 164 0.14530449181864 0.14530449181864 1 0.334996084744114 519 828 730 NA 525 512 164 244 902 675 392 565 M18554 GO_FILAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMIN_BINDING.html Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. 9/17 Gene Ontology MF GO:0031005 0.33296556889208 0.479387047544153 525 483.727272727273 522 0.0396825396825397 95 0.594274024984026 0.512148734479261 1 0.971999055581356 340 95 769 162 522 918 548 354 369 719 525 566 M18812 GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. 10/35 Gene Ontology MF GO:0005217 0.156740335436478 0.28120142475039 530 512.272727272727 522 0.0153787338226503 193 1.29994081892301 1.29994081892301 1 3.66879086147898 528 623 193 480 256 855 817 389 697 275 522 567 M19204 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 448/1070 Gene Ontology MF GO:0016772 0.119018697806626 0.230695218873008 865 541.090909090909 523 0.0114537979197991 145 1.14410692195658 1.33865560176332 1 3.73285667137451 864 523 576 727 228 145 843 904 423 451 268 568 M19209 GO_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY.html Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 210/431 Gene Ontology MF GO:0016874 0.00553121152647931 0.0409496374789913 425 469.545454545455 525 0.000504106106694046 15 0.92774260150467 1.0472256271066 1 6.5947799100234 425 810 574 858 590 15 525 266 563 492 47 569 M18544 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. 43/147 Gene Ontology MF GO:0015085 0.212126198191553 0.343584687211671 310 500.454545454545 526 0.0214411048329794 121 1.27680313775007 1.37508621895887 1 3.03439324981787 309 686 121 648 350 858 664 743 416 184 526 570 M18745 GO_ACTIVIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_BINDING.html Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits. 5/16 Gene Ontology MF GO:0048185 0.361333416573693 0.506748084219203 255 475.545454545455 527 0.0438469398104951 169 1.08918898596586 1.08918898596586 1 1.64699680211319 255 548 806 527 612 692 197 398 483 169 544 571 M17891 GO_BETA_2_MICROGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_2_MICROGLOBULIN_BINDING.html Interacting selectively and non-covalently with beta-2-microglobulin. 16/41 Gene Ontology MF GO:0030881 0.88126054194171 0.975643439935467 380 590.545454545455 528 0.176104220004057 376 0.263559800495638 -0.268476207043769 -1 0.0144570702232901 376 782 384 813 570 474 703 497 859 510 528 572 M17942 GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY.html Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 51/102 Gene Ontology MF GO:0070035 0.194639462787309 0.323812487819755 145 522.727272727273 528 0.0194862963213809 142 0.635897419203641 -0.635897419203641 -1 1.59508712414001 142 788 601 759 753 155 490 408 844 528 282 573 M18218 GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. 8/12 Gene Ontology MF GO:0052743 0.242643502534058 0.377081118802928 345 504.272727272727 528 0.0274094722715631 217 0.225018360519259 0.211961328532885 1 0.488202182030922 345 681 691 528 574 439 298 217 807 615 352 574 M18838 GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY.html Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. 11/31 Gene Ontology MF GO:0030159 0.0149403014978996 0.0772195358318408 810 514.909090909091 528 0.00136752154635784 22 0.77462355565514 -0.644872453133905 -1 4.41330159101407 810 22 405 90 65 898 528 834 323 813 876 575 M18589 GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY.html Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 5/17 Gene Ontology MF GO:0003906 0.783815517649749 0.891360044793287 485 554.636363636364 529 0.142009554285115 343 0.284456622237681 -0.319383149933093 -1 0.0727754349265193 596 410 774 343 540 529 481 482 799 727 420 576 M18625 GO_DEATH_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). 16/23 Gene Ontology MF GO:0005123 0.164499006075987 0.285007694142952 480 516.454545454545 529 0.0162057722508461 138 0.282612033833662 -0.33267333756443 -1 0.789156147147014 480 529 517 588 873 147 138 810 702 740 157 577 M17983 GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. 2/28 Gene Ontology MF GO:0022835 0.616951915360111 0.750788045147226 475 527.8 531 0.101134295546296 353 0.464258640077784 -0.464258640077784 -1 0.296026247222598 474 564 629 NA 526 434 609 353 741 536 412 578 M19094 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 9/18 Gene Ontology MF GO:0004675 0.00164666207277887 0.0187028284809452 765 484.272727272727 532 0.000164788351999336 21 1.23947019144583 -1.38975139692581 -1 10.9714674250434 761 148 891 108 21 830 724 532 367 90 855 579 M19109 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS.html Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). 29/59 Gene Ontology MF GO:0016763 0.294158790029991 0.439328063031804 675 552.181818181818 532 0.031173316032862 312 1.08991325512181 1.08991325512181 1 1.99424445538106 742 476 443 671 349 312 674 827 630 418 532 580 M18525 GO_RETINAL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_BINDING.html Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. 3/18 Gene Ontology MF GO:0016918 0.0765897756730953 0.184260033382694 535 514.181818181818 533 0.00793650793650794 104 0.671614246405927 0.81150114097999 1 2.52705087566792 533 383 763 446 410 696 677 260 104 711 673 581 M18380 GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. 7/25 Gene Ontology MF GO:0008139 0.799096701162871 0.904266869704602 460 570.727272727273 534 0.148276349551119 428 0.350196420717154 -0.32051653546405 -1 0.0783948552831622 456 499 728 534 592 456 625 471 816 673 428 582 M18426 GO_COPPER_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_BINDING.html Interacting selectively and non-covalently with copper (Cu) ions. 27/68 Gene Ontology MF GO:0005507 0.171473527172472 0.29377215083552 450 513.363636363636 534 0.0169552048063057 108 1.21831602395311 -0.930896232997513 -1 3.31989613963936 450 362 108 471 884 548 651 534 659 226 754 583 M18103 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. 5/12 Gene Ontology MF GO:0004865 0.336864426695552 0.482081651918856 455 518.818181818182 536 0.0402453331146389 253 0.364216433738918 -0.360091908674922 -1 0.591173608938808 451 536 665 735 586 405 478 253 612 579 407 584 M17984 GO_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. 25/47 Gene Ontology MF GO:0033558 0.110466759105106 0.221414854851193 495 498.818181818182 537 0.0105852506511593 103 0.272948638670074 -0.308207067868927 -1 0.915475352871152 493 721 561 719 678 103 376 521 631 537 147 585 M19001 GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. 10/30 Gene Ontology MF GO:0005242 0.514011397665828 0.660461572419779 685 500.545454545455 538 0.0634920634920635 276 1.42279293755586 -1.42279293755586 -1 1.31293557624881 682 613 293 592 538 644 577 345 451 276 495 586 M18109 GO_LIGAND_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 39/161 Gene Ontology MF GO:0022834 0.115632046135116 0.228261683703581 835 494.090909090909 539 0.0111089318640736 53 1.27890782231507 -1.21367705768745 -1 4.20283978214102 832 539 134 238 509 638 670 672 285 53 865 587 M18820 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. 19/45 Gene Ontology MF GO:0015932 0.0583669745579833 0.16678528620161 505 550.181818181818 542 0.0054523227381121 103 0.231577478091074 -0.276252033864036 -1 0.922676354956806 502 789 479 724 805 322 542 103 819 807 160 588 M18808 GO_POTASSIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_BINDING.html Interacting selectively and non-covalently with potassium (K+) ions. 9/25 Gene Ontology MF GO:0030955 0.0956179249911956 0.200841303634475 865 495.636363636364 544 0.01 28 1.23478542520635 -1.08023697533246 -1 4.40937893513487 865 94 823 28 401 778 693 544 260 88 878 589 M18905 GO_3_5_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. 30/52 Gene Ontology MF GO:0008408 0.421526074886784 0.570299983670355 300 557.727272727273 544 0.0485424093067289 242 0.839316232100865 -0.839316232100865 -1 1.04855926642847 299 883 544 836 531 242 595 406 685 834 280 590 M18955 GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. 8/19 Gene Ontology MF GO:0015166 0.521760551379655 0.666139416110226 850 583.181818181818 544 0.0711094605656892 241 0.497777135584641 0.607515543539787 1 0.449863570471488 310 498 861 619 544 394 241 879 850 848 371 591 M18580 GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 44/102 Gene Ontology MF GO:0004725 0.313736663622989 0.458155127830397 545 472.181818181818 545 0.0336476056970629 235 0.903622821473322 0.903622821473322 1 1.56903405235954 343 685 400 554 545 572 278 235 545 449 588 592 M18992 GO_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. 30/81 Gene Ontology MF GO:0019213 0.111339449886893 0.222195865284037 390 532.727272727273 545 0.0106735337661333 106 0.27015594005627 -0.303819584712458 -1 0.903992436563379 389 760 545 680 904 106 388 427 678 859 124 593 M18276 GO_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_ACTIVITY.html Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 2/27 Gene Ontology MF GO:0008066 0.616389130531739 0.750788045147226 475 545.7 546 0.100987653684181 352 0.464258640077784 -0.464258640077784 -1 0.296026247222598 475 565 703 NA 527 435 610 352 742 635 413 594 M18487 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. 33/74 Gene Ontology MF GO:0098811 0.00362224998284128 0.0320429806174421 590 434.363636363636 546 0.000329838883520064 25 0.8035527218967 -0.792904243146179 -1 6.15041184562444 590 41 207 25 32 892 546 798 110 699 838 595 M18603 GO_SPECTRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECTRIN_BINDING.html Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. 14/40 Gene Ontology MF GO:0030507 0.161385165508919 0.28120142475039 760 570.454545454545 546 0.0158730158730159 253 0.852246096011289 0.852246096011289 1 2.40527305631449 756 352 376 401 546 805 738 435 253 734 879 596 M18769 GO_RIBONUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. 824/1976 Gene Ontology MF GO:0032553 0.0256513399037139 0.103505406629021 565 520.727272727273 547 0.00259523375799465 52 1.07216558039164 1.22582275995943 1 5.40973481823219 536 864 812 890 243 52 561 565 547 490 168 597 M19226 GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. 22/59 Gene Ontology MF GO:0005544 0.161385165508919 0.28120142475039 550 497.727272727273 547 0.0158730158730159 156 1.99575500943266 1.99575500943266 1 5.63257013740406 547 527 156 670 665 864 606 222 250 391 577 598 M18156 GO_MHC_CLASS_II_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_RECEPTOR_ACTIVITY.html Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 5/10 Gene Ontology MF GO:0032395 0.67695752752714 0.801704316020179 375 554.818181818182 549 0.10684679178225 168 1.70932184675759 1.70932184675759 1 0.840412031897056 374 863 677 786 549 478 297 746 743 168 422 599 M18666 GO_DEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. 35/77 Gene Ontology MF GO:0004536 0.116115726057909 0.228261683703581 760 451.363636363636 549 0.0111581118978532 110 0.265042804849316 -0.332758661273574 -1 0.871002807123701 120 759 549 713 573 110 143 450 598 758 192 600 M18017 GO_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a substrate. 16/35 Gene Ontology MF GO:0032451 0.184212652584355 0.310964477757077 440 508.363636363636 551 0.0183389890046493 165 0.269075027599799 -0.288020585408978 -1 0.699182482058893 439 587 551 780 680 182 509 557 593 549 165 601 M18172 GO_PROTEIN_C_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_C_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 126/295 Gene Ontology MF GO:0008022 0.0754438467306577 0.184260033382694 685 523.909090909091 552 0.00710567906142959 177 1.055397604082 1.16141531865056 1 3.97109428095366 506 683 359 635 177 552 683 571 487 348 762 602 M18451 GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. 20/54 Gene Ontology MF GO:0052742 0.000236762979830383 0.00435643882887905 665 507.727272727273 552 2.15262239992906e-05 8 0.422809736865936 -0.365404493134925 -1 5.11303002180455 665 226 424 236 8 718 552 779 371 691 915 603 M18118 GO_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_LIPASE_ACTIVITY.html Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. 2/30 Gene Ontology MF GO:0004806 0.193227944015785 0.322046573359642 525 493.4 553.5 0.0235747917332767 204 0.768911774234612 -0.119087346555161 -1 1.9380945300276 522 276 666 NA 750 703 350 204 258 585 620 604 M18472 GO_ALPHA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. 16/35 Gene Ontology MF GO:0043014 0.0839184282471183 0.184260033382694 880 535 554 0.00793650793650794 134 1.47537367091781 -1.01405746558881 -1 5.55131827337594 878 774 307 348 340 697 875 554 146 134 832 605 M17952 GO_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 13/38 Gene Ontology MF GO:0019212 0.667434366415499 0.79538810505474 830 591.454545454545 555 0.0952380952380952 312 0.304896413501389 -0.287340680731083 -1 0.155271322400591 828 312 510 555 740 622 813 381 519 530 696 606 M18082 GO_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. 82/349 Gene Ontology MF GO:0022836 0.0587789910770852 0.167420036504391 525 466.272727272727 555 0.00549189148173081 48 1.49195502035655 1.6310940016911 1 5.93180408650262 521 555 77 237 556 853 613 784 124 48 761 607 M18766 GO_SINGLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with single-stranded DNA. 52/108 Gene Ontology MF GO:0003697 0.560155979986244 0.700194974982805 205 580 555 0.071947364602651 205 0.244167461843572 -0.2585944215137 -1 0.193582793644169 205 866 555 857 470 287 562 517 835 784 442 608 M18832 GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 14/25 Gene Ontology MF GO:0005086 0.0952262358286732 0.200841303634475 785 568.545454545455 557 0.00905604934796769 199 0.302510210012353 -0.33577641576306 -1 1.08025409994265 781 339 487 426 199 694 720 760 557 811 480 609 M18940 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 201/490 Gene Ontology MF GO:0004674 0.290040669696273 0.433881977431823 870 609.090909090909 559 0.0306608130110619 189 1.00934153606446 -0.791129936297556 -1 1.87482835483608 868 666 559 870 532 189 847 911 510 460 288 610 M18194 GO_RAN_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAN_GTPASE_BINDING.html Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. 12/38 Gene Ontology MF GO:0008536 0.861307305450344 0.96048814668402 485 600 560 0.164387608843309 420 0.269819445176038 -0.241370298150279 -1 0.0241973969247323 484 740 438 788 822 420 560 423 769 606 550 611 M19077 GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. 28/59 Gene Ontology MF GO:0016278 0.036518234524834 0.123967534382894 885 513.181818181818 560 0.00337626180353272 74 0.240680196593328 -0.267517230481622 -1 1.11779381912891 275 799 560 882 608 97 303 405 758 884 74 612 M18307 GO_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids. 100/224 Gene Ontology MF GO:0004518 0.0816184501521273 0.184260033382694 585 566 561 0.00771033469553163 182 1.30938674652232 1.46607691799613 1 4.92676715946524 583 744 552 812 182 337 687 868 472 428 561 613 M18166 GO_NITRIC_OXIDE_SYNTHASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_SYNTHASE_BINDING.html Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. 15/45 Gene Ontology MF GO:0050998 0.081650905317405 0.184260033382694 400 529.454545454545 562 0.00771352265972096 88 1.60817712248608 1.60817712248608 1 6.05101151072108 396 895 88 667 832 606 242 797 406 333 562 614 M18317 GO_SNAP_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNAP_RECEPTOR_ACTIVITY.html Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. 20/39 Gene Ontology MF GO:0005484 0.629004576153179 0.762306640027014 505 613 562 0.0861988787428567 376 0.207790131752326 -0.243782252247606 -1 0.125455705003559 505 868 562 871 466 376 390 756 837 651 461 615 M18072 GO_RNA_POLYMERASE_I_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_I_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 5/14 Gene Ontology MF GO:0001054 0.536777423433341 0.678345095547628 370 587.727272727273 563 0.0740682594373872 249 0.12678357067483 0.147119501758894 1 0.109458881742428 367 901 660 806 465 452 249 563 899 574 529 616 M18345 GO_ION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ion A(out) + ion B(in) = ion A(in) + ion B(out) where ion A and ion B are different types of ion. 12/57 Gene Ontology MF GO:0099516 0.775485941583084 0.882979042396581 560 579.818181818182 564 0.126984126984127 279 1.08023697533246 -1.08023697533246 -1 0.299070071669727 557 540 279 564 742 885 514 747 573 297 680 617 M18867 GO_NF_KAPPAB_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NF_KAPPAB_BINDING.html Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. 19/42 Gene Ontology MF GO:0051059 0.596677880261637 0.737627977174182 570 573.090909090909 564 0.0792320679279215 260 0.653874098340854 0.653874098340854 1 0.442653838501237 566 528 498 517 893 564 260 436 653 822 567 618 M19172 GO_MACROMOLECULAR_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_BINDING.html Interacting selectively and non-covalently with any macromolecular complex. 776/1921 Gene Ontology MF GO:0044877 0.0609907406242961 0.169901659825281 455 537.272727272727 565 0.00627323447753433 166 1.32662144177601 1.38936056386308 1 5.23103768013704 452 735 905 624 166 565 602 440 304 281 836 619 M19186 GO_PHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 36/92 Gene Ontology MF GO:0019208 0.241953103134348 0.376644424506937 565 599.454545454545 565 0.0248682897187092 273 0.269559467309182 -0.256620930805747 -1 0.585533915445098 768 334 586 563 319 550 907 273 565 909 820 620 M18515 GO_ELECTRON_CARRIER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_CARRIER_ACTIVITY.html Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 68/160 Gene Ontology MF GO:0009055 0.119108944526825 0.230695218873008 610 501.909090909091 566 0.0114630043072043 114 1.23820018990492 -1.59008010255122 -1 4.03985306247083 607 566 401 729 769 114 608 474 576 471 206 621 M18634 GO_3_5_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_DNA_HELICASE_ACTIVITY.html Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. 7/13 Gene Ontology MF GO:0043138 0.738062064821273 0.854109559290026 535 606.090909090909 566 0.12537912233875 353 0.205374235692744 -0.27949232670671 -1 0.0720462150397134 535 522 784 566 803 371 353 670 828 744 491 622 M18857 GO_SNARE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_BINDING.html Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 68/160 Gene Ontology MF GO:0000149 0.467555304638474 0.619813948512098 730 587.727272727273 566 0.055687227090676 257 1.53334444632203 1.53334444632203 1 1.63161842475439 729 772 500 829 434 257 671 725 566 472 510 623 M18055 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY.html Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. 13/39 Gene Ontology MF GO:0061650 0.747104480155064 0.862404167807603 835 629.272727272727 567 0.117485354282846 360 0.285947796168705 -0.318899760829496 -1 0.0941641125642231 481 834 360 831 516 466 874 602 860 567 531 624 M18688 GO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 95/190 Gene Ontology MF GO:0016829 0.307427912082638 0.45325910114748 650 485.727272727273 567 0.0328433622762947 197 0.799698613934561 0.792018949179125 1 1.40769519699968 567 325 251 650 650 197 592 650 688 483 290 625 M18958 GO_MYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_BINDING.html Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. 48/108 Gene Ontology MF GO:0017022 0.232850105696956 0.366191619215725 790 532.090909090909 567 0.0238095238095238 129 1.3420103568543 -2.07333958077616 -1 2.99912313642857 789 567 129 400 659 686 814 229 291 455 834 626 M18056 GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. 7/21 Gene Ontology MF GO:1990939 0.644907056543027 0.775574499372007 295 567.090909090909 568 0.0983578536015007 295 0.862559895960135 -0.862559895960135 -1 0.487671384139622 295 702 653 721 905 362 494 372 810 568 356 627 M18243 GO_MANGANESE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_BINDING.html Interacting selectively and non-covalently with manganese (Mn) ions. 33/69 Gene Ontology MF GO:0030145 0.414794787080257 0.565001584554032 390 550.090909090909 568 0.0475411999426592 334 0.790636173703809 -0.946863186450032 -1 1.00415999965086 572 444 389 568 389 365 802 844 721 623 334 628 M18668 GO_RRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_BINDING.html Interacting selectively and non-covalently with ribosomal RNA. 42/89 Gene Ontology MF GO:0019843 0.277444555807471 0.417756123310758 760 557.727272727273 570 0.0291098231552103 332 0.751302067173766 0.751302067173766 1 1.45882694944269 570 626 605 756 339 366 760 332 534 759 488 629 M18739 GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. 11/18 Gene Ontology MF GO:0015101 0.00160590902102864 0.0187028284809452 605 541.090909090909 570 0.000146098406142978 19 0.74008542162695 0.74008542162695 1 6.5510434069058 601 570 340 720 19 859 736 361 526 779 441 630 M19051 GO_METALLOAMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOAMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 7/13 Gene Ontology MF GO:0070006 0.692053852342561 0.81566429689812 435 636.181818181818 570 0.111111111111111 360 0.315466212749178 0.475169291147836 1 0.142988494462075 435 712 878 676 847 557 360 549 539 875 570 631 M18422 GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME.html The action of a molecule that contributes to the structural integrity of the ribosome. 129/311 Gene Ontology MF GO:0003735 0.515814667428916 0.661854245515486 575 596.272727272727 571 0.0638085002954384 415 0.826986611116147 0.958318893898104 1 0.759257721343545 571 829 607 801 422 415 894 447 586 487 500 632 M18497 GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 38/96 Gene Ontology MF GO:0004702 0.557443745451391 0.697752715394939 465 598.181818181818 572 0.0714285714285714 317 1.30215177399926 -1.38975139692581 -1 1.04250431227011 760 572 465 416 462 866 652 837 467 317 766 633 M18540 GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of potassium ions (K+) from one side of a membrane to the other. 45/152 Gene Ontology MF GO:0015079 0.198391186474109 0.327096579849786 595 509.272727272727 572 0.0199024204000635 69 1.34638126193026 1.40962546558766 1 3.34704387410144 592 269 162 245 791 920 572 890 280 69 812 634 M18297 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. 43/95 Gene Ontology MF GO:0004722 0.0215437267487063 0.0955217375675287 720 514.818181818182 573 0.0019779667563433 82 0.250914105287731 -0.264387444740038 -1 1.31082066124051 720 517 573 711 82 243 510 598 820 643 246 635 M18827 GO_SNRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_BINDING.html Interacting selectively and non-covalently with a small nuclear RNA (snRNA). 18/42 Gene Ontology MF GO:0017069 0.828757989501034 0.933240330894677 420 651 574 0.148218485448835 400 0.818634081759665 -0.818634081759665 -1 0.125824813982547 416 907 508 846 861 400 574 570 766 810 503 636 M18417 GO_CARBOHYDRATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. 7/20 Gene Ontology MF GO:0019200 0.69375433572529 0.816138180905682 575 565.454545454545 575 0.111603180917178 368 0.36376194537094 0.389220126234449 1 0.164409082428802 575 381 736 551 563 627 439 368 643 680 657 637 M18626 GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY.html Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. 2/8 Gene Ontology MF GO:0016175 0.0606750977570307 0.169668966372244 380 521.5 575.5 0.0069307431621849 85 0.214179446581477 0.214179446581477 1 0.845189771976523 377 590 781 NA 561 353 85 637 706 741 384 638 M18753 GO_PROLINE_RICH_REGION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROLINE_RICH_REGION_BINDING.html Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. 13/26 Gene Ontology MF GO:0070064 0.610374428119871 0.747728993169483 580 568.181818181818 577 0.0821195242594274 302 0.260293316277461 0.280882245757086 1 0.168335426541479 467 690 541 613 460 605 302 577 636 783 576 639 M19188 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING.html Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. 26/57 Gene Ontology MF GO:0032813 0.557443745451391 0.697752715394939 850 613 577 0.0714285714285714 335 0.330181040927112 -0.3667048404442 -1 0.26434324384429 847 335 468 577 729 344 765 835 476 910 457 640 M18585 GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). 20/44 Gene Ontology MF GO:0016776 0.499242852414227 0.649651236522049 425 541.181818181818 578 0.060939921990472 266 0.240615079902473 -0.26963271915113 -1 0.230870106946884 424 592 567 638 672 266 392 578 761 726 337 641 M19122 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. 5/18 Gene Ontology MF GO:0015095 0.477598883102048 0.630622835757095 695 572.181818181818 578 0.0628687729167733 230 0.403507452942448 0.593099693508844 1 0.413849873523628 290 694 898 654 695 511 230 387 463 894 578 642 M18031 GO_ESTROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an estrogen receptor. 18/56 Gene Ontology MF GO:0030331 0.902082952308205 0.99153681735191 710 581 579 0.190419858945668 353 1.05919280447021 1.05919280447021 1 0.020026077948033 708 716 432 440 587 498 565 803 710 353 579 643 M18864 GO_TRANSLATION_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY.html Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 16/42 Gene Ontology MF GO:0045182 0.698152987361708 0.816138180905682 840 573.818181818182 579 0.103174603174603 341 1.16186250822327 -1.16186250822327 -1 0.525126012306697 837 796 536 579 599 485 588 392 529 341 630 644 M19189 GO_PROTEIN_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHANNEL_ACTIVITY.html Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel. 4/12 Gene Ontology MF GO:0015266 0.115508082306416 0.228261683703581 915 558.727272727273 579 0.0121991696925166 234 0.247561622766541 0.20126591981623 1 0.813554874877271 629 496 911 386 238 579 397 234 760 911 605 645 M18357 GO_IMMUNOGLOBULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. 2/121 Gene Ontology MF GO:0034987 0.0701699479746458 0.184260033382694 725 559.1 579.5 0.00805113121376293 91 0.27863829001966 -0.423283103193533 -1 1.04841891598189 725 629 721 NA 530 465 91 499 752 664 515 646 M17965 GO_TAU_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_BINDING.html Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. 12/20 Gene Ontology MF GO:0048156 0.631680674611997 0.762559975108467 725 590.454545454545 580 0.0868000811461946 246 0.405132245420516 -0.290926281338473 -1 0.244303971556061 722 581 246 589 468 891 449 537 580 534 898 647 M18088 GO_ACTIN_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BINDING.html Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. 70/170 Gene Ontology MF GO:0051015 0.0839184282471183 0.184260033382694 585 475.909090909091 580 0.00793650793650794 122 1.32466758342097 1.21661904560329 1 4.98426363842766 582 451 122 185 580 839 685 636 158 220 777 648 M18423 GO_14_3_3_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_14_3_3_PROTEIN_BINDING.html Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. 17/67 Gene Ontology MF GO:0071889 0.335592265866599 0.482081651918856 605 554.909090909091 581 0.0364867349773679 338 0.361411610382975 0.406381824107831 1 0.586620991917803 523 552 338 601 362 815 601 360 581 683 688 649 M18602 GO_DRUG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_BINDING.html Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 65/211 Gene Ontology MF GO:0008144 0.0839184282471183 0.184260033382694 180 438.363636363636 581 0.00793650793650794 95 1.3296731375769 1.3296731375769 1 5.00309779922203 589 179 95 183 696 702 655 581 179 198 765 650 M18652 GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). 9/33 Gene Ontology MF GO:0015298 0.481063017846562 0.63225425202691 585 558.545454545455 581 0.0634920634920635 132 1.08023697533246 -1.08023697533246 -1 1.10171641191071 581 132 791 144 885 876 500 806 447 258 724 651 M18926 GO_INORGANIC_ANION_EXCHANGER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_EXCHANGER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). 3/24 Gene Ontology MF GO:0005452 0.147859119791321 0.270976872924334 360 547.636363636364 581 0.0158730158730159 131 1.67949129323189 1.67949129323189 1 4.87836521326557 357 779 853 502 581 514 638 862 196 131 611 652 M18323 GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. 11/19 Gene Ontology MF GO:0010485 0.755981760261934 0.87024380006868 805 592.454545454545 583 0.120347548699124 380 0.164186397036127 -0.19782382762489 -1 0.0507621567026401 577 802 591 745 583 437 407 380 804 655 536 653 M18995 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS.html Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). 105/227 Gene Ontology MF GO:0016741 0.191792810956866 0.320234820472443 490 535.727272727273 583 0.01917173288731 150 0.964916235402726 -0.810865129405406 -1 2.44424706060156 269 858 592 881 721 150 583 486 619 486 248 654 M19100 GO_CARBON_OXYGEN_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_OXYGEN_LYASE_ACTIVITY.html Catalysis of the breakage of a carbon-oxygen bond. 44/77 Gene Ontology MF GO:0016835 0.43119990772354 0.579976484072598 615 556.454545454545 585 0.05 89 0.784597602722347 0.924440006815576 1 0.950832877370037 615 89 363 508 718 333 895 691 585 888 436 655 M19213 GO_SEMAPHORIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_ACTIVITY.html Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 3/11 Gene Ontology MF GO:0017154 0.934675046253905 0.999999414526698 920 640.272727272727 585 0.238783994843014 362 0.397258199919961 0.397258199919961 1 3.78424338514894e-07 362 616 918 523 669 496 540 574 842 918 585 656 M18025 GO_RACEMASE_AND_EPIMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RACEMASE_AND_EPIMERASE_ACTIVITY.html Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. 4/18 Gene Ontology MF GO:0016854 0.523195199398655 0.666139416110226 595 618.090909090909 586 0.0713884909478666 445 0.210779201854096 -0.333863059545985 -1 0.190490558250052 595 816 642 793 445 446 493 533 896 554 586 657 M18722 GO_RNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. 34/69 Gene Ontology MF GO:0003724 0.227072571312883 0.360806158217361 835 570.818181818182 587 0.0231434504735691 172 0.221021638574034 -0.228445774775 -1 0.501223422700888 224 832 587 835 720 172 530 457 852 774 296 658 M19228 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. 28/59 Gene Ontology MF GO:0042054 0.404750749114496 0.553299686753843 360 583.454545454545 587 0.0460665495192586 237 0.18155996515152 -0.184209610585807 -1 0.239045973465706 360 847 603 874 524 237 587 342 855 920 269 659 M18535 GO_LIGASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_REGULATOR_ACTIVITY.html Modulates the activity of a ligase. 8/20 Gene Ontology MF GO:0055103 0.0344366995229073 0.121852936773364 160 424.818181818182 588 0.00349822857923241 88 0.360250387170619 -0.409052319992174 -1 1.68690309023179 157 588 765 605 642 140 131 88 738 714 105 660 M18695 GO_PROTEIN_PHOSPHATASE_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_1_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 1. 9/30 Gene Ontology MF GO:0008157 0.0435410817750028 0.138608288003469 590 550.090909090909 588 0.00444184978783262 143 0.385920234279147 -0.3290206555801 -1 1.69649697252452 588 207 800 448 143 673 505 728 458 767 734 661 M18909 GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a potassium channel. 26/60 Gene Ontology MF GO:0015459 0.767075861396485 0.876658127310268 390 547.727272727273 589 0.124060632656146 336 0.858982002181133 0.858982002181133 1 0.251542639965602 726 336 390 389 715 368 589 404 646 836 626 662 M19099 GO_PURINERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_ACTIVITY.html Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 10/26 Gene Ontology MF GO:0035586 0.247892868708513 0.383777520224612 245 558.545454545455 589 0.0255653905632326 158 0.960186285948682 0.960186285948682 1 2.04563130384007 242 854 394 838 589 501 158 608 658 887 415 663 M17947 GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 5/21 Gene Ontology MF GO:0008308 0.301913617378501 0.447279433153336 340 505.636363636364 591 0.0353030251481494 203 0.219858996077961 -0.219858996077961 -1 0.393509097146177 338 674 625 701 591 203 245 610 773 529 273 664 M18136 GO_GLUCOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. 5/12 Gene Ontology MF GO:0015926 0.311720165948143 0.458119093725705 565 617.727272727273 591 0.0366668518930194 363 0.204151735408056 0.173756636466547 1 0.354520932539452 563 554 670 645 363 763 545 576 797 591 728 665 M18434 GO_BETA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. 28/46 Gene Ontology MF GO:0048487 0.0947625083899893 0.200417259123656 810 578 591 0.00900988804655943 198 1.9366898762468 1.9366898762468 1 6.92496308290905 808 794 407 515 198 659 862 591 238 411 875 666 M17921 GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a sulfur compound from one side of the membrane to the other. 6/29 Gene Ontology MF GO:1901682 0.214139132665174 0.343818502708482 600 512.545454545455 592 0.0238095238095238 185 1.34349992948527 1.34349992948527 1 3.19086869260963 600 274 619 413 649 767 750 519 270 185 592 667 M18479 GO_TRANSITION_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_BINDING.html Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 586/1709 Gene Ontology MF GO:0046914 0.117499341287128 0.229510390624538 795 586.727272727273 593 0.0124217791690288 240 1.16933832180766 1.40328049168802 1 3.82857301597573 795 736 750 880 240 314 759 593 348 480 559 668 M18791 GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. 21/46 Gene Ontology MF GO:0018024 0.673266115296045 0.799494024032422 595 659.181818181818 593 0.0966920463724862 376 0.19031902084736 -0.19867301684671 -1 0.094741750353706 593 885 589 889 489 431 848 500 857 794 376 669 M18104 GO_HYDRO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDRO_LYASE_ACTIVITY.html Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. 34/52 Gene Ontology MF GO:0016836 0.816521443770307 0.920587902290052 890 629.545454545455 594 0.142857142857143 212 0.784597602722347 0.924440006815576 1 0.144418431412579 889 212 283 547 892 573 742 906 594 580 707 670 M18142 GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 12/30 Gene Ontology MF GO:0016891 0.96855221189793 0.999999414526698 720 603.909090909091 594 0.26984126984127 396 0.259854151167298 -0.262717795705081 -1 1.99465701570746e-07 717 435 543 396 758 536 767 558 715 594 624 671 M18177 GO_R_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_R_SMAD_BINDING.html Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. 15/30 Gene Ontology MF GO:0070412 0.394251768110702 0.540553840032558 595 588.636363636364 594 0.0445490914470515 227 0.255587641364664 -0.315040244979926 -1 0.34976343631008 594 849 526 784 821 227 358 863 543 602 308 672 M18677 GO_RAL_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAL_GTPASE_BINDING.html Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. 8/21 Gene Ontology MF GO:0017160 0.0529671431451299 0.157301636349229 385 560.818181818182 594 0.0054273674005465 155 0.481449101090274 -0.481449101090274 -1 1.98094192788676 546 594 796 617 155 383 869 758 306 762 383 673 M18152 GO_RNA_POLYMERASE_II_CORE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_BINDING.html Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. 9/22 Gene Ontology MF GO:0000993 0.0899610242487097 0.193516954120293 370 526.727272727273 596 0.00938249214062115 203 0.955023857704091 0.955023857704091 1 3.48928502212478 611 288 676 370 203 852 366 829 276 596 727 674 M18154 GO_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_BINDING.html Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. 91/227 Gene Ontology MF GO:0003729 0.298491760414149 0.443284248075929 555 596.545454545455 596 0.0317155004073516 352 1.13600996091908 1.12954682409303 1 2.05593369721686 554 604 596 607 352 895 529 690 478 410 847 675 M18482 GO_TELOMERIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERIC_DNA_BINDING.html Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. 18/38 Gene Ontology MF GO:0042162 0.542093777963162 0.683310113308718 540 610.909090909091 596 0.0685458026652062 289 0.205883276221693 -0.197349759265846 -1 0.174409830837343 538 893 513 848 655 289 495 596 889 698 306 676 M18020 GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding. 10/22 Gene Ontology MF GO:0044183 0.457878368676389 0.610504491568519 630 569 597 0.054139746681737 254 0.226831583651328 -0.269460929980683 -1 0.24900589049154 458 691 471 639 626 254 629 597 892 551 451 677 M18507 GO_PHOSPHOTYROSINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTYROSINE_BINDING.html Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. 7/23 Gene Ontology MF GO:0001784 0.619142721311074 0.752458789440143 595 622.727272727273 597 0.0920201180464536 344 0.161974216989862 -0.196859270285625 -1 0.102478938963412 591 806 755 595 597 427 482 681 869 703 344 678 M19195 GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 11/30 Gene Ontology MF GO:0017112 0.0583748501705635 0.16678528620161 600 577.363636363636 597 0.00545307893909147 156 0.316026864901217 0.303577391488623 1 1.25914890306032 597 341 488 425 156 889 622 613 499 914 807 679 M17903 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. 6/30 Gene Ontology MF GO:0031434 0.355622439087378 0.504855532885815 600 602.909090909091 598 0.0429953656845824 241 0.151701928076495 -0.16739189452005 -1 0.230655833792092 598 900 616 775 643 447 568 442 887 515 241 680 M18389 GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group (CH3-) to a protein. 43/84 Gene Ontology MF GO:0008276 0.00903389824387468 0.0563915293707776 110 448.454545454545 598 0.000824655360710795 27 0.225116626013345 -0.253344286837153 -1 1.43998243141588 106 830 598 821 736 27 192 216 695 676 36 681 M18531 GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. 32/69 Gene Ontology MF GO:0034212 0.454478835606233 0.606851275410355 605 592.727272727273 602 0.0536020688977151 253 0.197096959946105 -0.223767418952431 -1 0.218996060279243 441 890 602 866 478 253 604 541 794 712 339 682 M19041 GO_NOTCH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_BINDING.html Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. 8/30 Gene Ontology MF GO:0005112 0.721499023990598 0.838104926857765 515 605.272727272727 602 0.12 184 0.500247992203583 0.521537458968868 1 0.19654006948317 514 184 876 364 602 754 443 787 682 872 580 683 M18178 GO_CIS_TRANS_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_TRANS_ISOMERASE_ACTIVITY.html Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. 16/44 Gene Ontology MF GO:0016859 0.797570030580185 0.904266869704602 635 565.909090909091 603 0.135163374397706 338 0.340196836911869 -0.259115336415532 -1 0.0761563477810136 632 338 442 586 651 385 630 793 609 603 556 684 M17913 GO_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLASE_ACTIVITY.html Catalysis of a ring closure reaction. 9/23 Gene Ontology MF GO:0009975 0.329297798587886 0.478325840867187 865 544.181818181818 604 0.0391557994409881 75 0.474463009258705 -0.400576320837916 -1 0.778374300278519 863 75 617 283 367 604 513 687 746 517 714 685 M19191 GO_HISTONE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 15/49 Gene Ontology MF GO:0035173 0.765573338011193 0.876029192749126 845 628.181818181818 604 0.123548458053179 233 0.323855208153248 0.303653930616888 1 0.0953540950441773 387 739 233 845 845 586 318 604 851 912 590 686 M17953 GO_MAGNESIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_BINDING.html Interacting selectively and non-covalently with magnesium (Mg) ions. 114/271 Gene Ontology MF GO:0000287 0.0748065540555376 0.184260033382694 625 533 606 0.00704348055704555 82 1.13734789393646 1.26386922347237 1 4.27944474289705 625 714 472 675 859 82 422 623 606 439 346 687 M18196 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 11/29 Gene Ontology MF GO:0008519 0.746939216492813 0.862404167807603 610 551.545454545455 607 0.117432941586163 216 1.03855172572717 1.03855172572717 1 0.342000908937572 491 622 216 603 754 582 607 641 608 285 658 688 M18197 GO_PHOSPHATASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVATOR_ACTIVITY.html Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 5/11 Gene Ontology MF GO:0019211 0.144389697673413 0.267678113665751 615 526.909090909091 607 0.0154730688076111 252 0.313648180678602 -0.215493888011047 -1 0.91958985501342 612 372 685 252 257 725 382 714 481 607 709 689 M19183 GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. 24/53 Gene Ontology MF GO:0005547 0.649352548932513 0.77888441332192 845 591.545454545455 607 0.090872891456366 201 1.99575500943266 1.99575500943266 1 1.1094468936143 843 607 201 748 739 508 657 573 637 400 594 690 M18148 GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. 7/17 Gene Ontology MF GO:0017110 0.107458096642106 0.217277909693928 680 507.454545454545 609 0.0113038079804979 185 1.0296882537552 -1.0296882537552 -1 3.49679897758777 676 185 675 263 225 669 878 873 318 211 609 691 M18991 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/50 Gene Ontology MF GO:0016667 0.232709049122008 0.366191619215725 665 563.818181818182 609 0.0237932076218758 241 0.919307359165357 -0.919307359165357 -1 2.05446694023986 661 609 241 526 313 271 836 752 725 858 410 692 M18871 GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. 4/12 Gene Ontology MF GO:0010857 0.598881260040338 0.73856670139023 610 627.909090909091 610 0.0873015873015873 349 0.284916164869298 -0.119604775226518 -1 0.192073821183201 610 506 835 513 794 807 450 349 503 823 717 693 M19201 GO_THIOESTERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTERASE_BINDING.html Interacting selectively and non-covalently with any thioesterase enzyme. 6/16 Gene Ontology MF GO:0031996 0.481063017846562 0.63225425202691 385 573.727272727273 610 0.0634920634920635 197 1.14672566625037 1.14672566625037 1 1.16952717279348 382 776 914 610 766 739 365 640 443 197 479 694 M18007 GO_NEUROPEPTIDE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neuropeptide receptor. 3/31 Gene Ontology MF GO:0071855 0.7184702227596 0.835641725586387 655 597.090909090909 611 0.119047619047619 428 0.521701698669784 0.682255495882233 1 0.208384848320208 654 514 635 432 829 611 678 428 549 545 693 695 M18209 GO_GLUTATHIONE_PEROXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_PEROXIDASE_ACTIVITY.html Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. 11/17 Gene Ontology MF GO:0004602 0.597318307603006 0.737627977174182 755 570.636363636364 611 0.0793650793650794 248 0.395586823676875 -0.319362032684163 -1 0.267800774659657 616 504 248 550 658 752 348 751 486 611 753 696 M18304 GO_GLUCOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_BINDING.html Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. 6/16 Gene Ontology MF GO:0005536 0.331707699599755 0.479387047544153 370 607.272727272727 612 0.0395015999965883 369 0.226112594314469 0.261113863960383 1 0.369831370249318 443 835 708 814 369 612 369 446 863 647 574 697 M18327 GO_HISTONE_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a histone. 14/27 Gene Ontology MF GO:0032452 0.506488164087162 0.65629452247914 535 566 614 0.062183301997558 294 0.284780732666799 -0.313797684064614 -1 0.26680169175795 531 642 519 738 704 324 579 625 614 656 294 698 M18534 GO_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVITY.html Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 130/313 Gene Ontology MF GO:0016791 0.200888379193247 0.330030908674621 480 597 615 0.0201803801801038 291 1.17702003025429 1.17702003025429 1 2.90263521397051 683 707 480 794 291 477 615 647 607 461 805 699 M18221 GO_PHOSPHOLIPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_BINDING.html Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. 15/29 Gene Ontology MF GO:0043274 0.344625109759315 0.491558296090806 710 613.545454545455 616 0.037685002240571 186 0.665455983212677 -0.665455983212677 -1 1.05130905909317 707 783 420 545 578 821 186 757 453 616 883 700 M19020 GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. 51/118 Gene Ontology MF GO:0019783 0.665403681994949 0.793996611459602 750 619.727272727273 618 0.0947372491313704 385 1.41813868093395 1.41813868093395 1 0.727724678787839 907 633 494 687 484 618 581 748 532 385 748 701 M18638 GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. 9/21 Gene Ontology MF GO:0034236 0.569396614170871 0.709816917394582 615 643.090909090909 620 0.0808048080061766 457 0.283559854589672 -0.237488419966691 -1 0.21620491627304 773 636 787 614 457 578 459 620 791 747 612 702 M19174 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. 4/12 Gene Ontology MF GO:0016861 0.898685274461517 0.99016820659233 495 650.272727272727 621 0.204633569194333 426 0.155453393065936 -0.204722621437506 -1 0.0034166849943665 495 676 906 702 621 507 426 539 834 904 543 703 M19125 GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a chloride channel. 6/19 Gene Ontology MF GO:0017081 0.837031963868184 0.939603975324412 450 635.636363636364 622 0.165915130220746 373 0.206893406316087 -0.269923941870762 -1 0.0286718794137429 405 769 899 622 877 450 373 449 716 895 537 704 M18880 GO_DRUG_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORTER_ACTIVITY.html Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 10/30 Gene Ontology MF GO:0090484 0.35943518917414 0.504855532885815 830 653.545454545455 623 0.0396825396825397 397 0.376228538838846 -0.408225857149135 -1 0.57203846797595 819 406 418 597 623 827 858 531 397 826 887 705 M18277 GO_GAMMA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. 13/46 Gene Ontology MF GO:0043015 0.208940249063368 0.339021215411461 565 607.727272727273 624 0.0210820345040522 300 0.327930567376788 -0.293383559451109 -1 0.789099174996619 564 353 453 493 300 884 867 707 624 636 804 706 M19108 GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. 7/11 Gene Ontology MF GO:0008195 0.632427457617131 0.762559975108467 510 646 624 0.0952380952380952 409 0.367694515209285 -0.329784670739293 -1 0.22172815468898 508 624 893 708 761 441 409 898 521 889 454 707 M17899 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 10/30 Gene Ontology MF GO:0016675 0.850621352955467 0.950876846560181 875 658 627 0.158730158730159 434 0.88632027725861 0.88632027725861 1 0.0993148471259656 875 492 499 627 801 687 912 434 610 513 788 708 M18716 GO_PROTEIN_KINASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVITY.html Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. 9/16 Gene Ontology MF GO:0004697 0.527911917049359 0.669806815483721 775 645 628 0.0723112205710055 246 0.313821539442266 0.315916887138722 1 0.279781665732118 609 547 802 628 912 623 246 488 692 773 775 709 M18741 GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the directed movement of water (H2O) from one side of a membrane to the other. 7/14 Gene Ontology MF GO:0005372 0.66494951094013 0.793996611459602 630 627.545454545455 629 0.103581056568396 290 0.465098797662579 -0.480765718076512 -1 0.238667589591334 723 505 805 399 542 629 290 734 868 780 628 710 M18731 GO_GUANYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. 186/417 Gene Ontology MF GO:0019001 0.285388964703663 0.42831622761398 740 635.181818181818 630 0.03008514538129 342 1.04507879900415 1.08019351010833 1 1.97122512737283 738 630 563 837 342 517 755 851 491 446 817 711 M19092 GO_PRE_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MRNA_BINDING.html Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. 16/40 Gene Ontology MF GO:0036002 0.465924593304175 0.619163808606206 630 635.363636363636 630 0.0554246711037773 276 0.204871153629501 -0.221725195294112 -1 0.218479783371727 630 908 466 876 732 402 621 346 847 885 276 712 M18764 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES.html Catalysis of the transfer of a phosphate group from one position to another within a single molecule. 6/10 Gene Ontology MF GO:0016868 0.0765897756730953 0.184260033382694 695 541.363636363636 631 0.00793650793650794 13 1.70956702222945 1.70956702222945 1 6.43250646916215 692 418 810 270 577 723 866 762 13 193 631 713 M18868 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. 5/29 Gene Ontology MF GO:0015347 0.519378241639125 0.664572993474263 585 578.545454545455 631 0.0706477755144706 170 1.25240526293404 1.25240526293404 1 1.13841425966528 585 661 833 525 534 631 240 818 713 170 654 714 M19180 GO_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_BINDING.html Interacting selectively and non-covalently with an RNA molecule or a portion thereof. 910/2094 Gene Ontology MF GO:0003723 0.380613610843461 0.528949428966744 315 607.454545454545 631 0.0467733718285723 240 1.02162418148692 1.28035783916606 1 1.44738035973961 311 919 909 893 631 240 692 546 662 494 385 715 M18105 GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY.html Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. 26/75 Gene Ontology MF GO:0003743 0.367824007920601 0.515065581867508 855 648.272727272727 632 0.0408327018111711 372 0.222592707152133 -0.266097101540986 -1 0.32852776943044 855 650 604 704 372 632 917 589 512 581 715 716 M18271 GO_DIPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a dipeptide. 4/14 Gene Ontology MF GO:0016805 0.239666058626299 0.374351059314423 715 604.818181818182 634 0.0270277863136928 330 0.429513211137809 -0.282161549553138 -1 0.938819301350229 713 382 702 562 330 577 839 824 440 634 650 717 M18453 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 46/107 Gene Ontology MF GO:0004197 0.0487671505549725 0.148562180498592 690 573.090909090909 634 0.00453481376427923 144 1.35166014992971 1.35166014992971 1 5.73333803634126 689 634 198 698 144 834 347 895 591 361 913 718 M18772 GO_RETINOIC_ACID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. 16/135 Gene Ontology MF GO:0042974 0.403395979379396 0.552268305102744 410 550.181818181818 634 0.0458693784699724 235 0.342950432764133 -0.303030091967762 -1 0.452959899043229 408 652 368 683 634 235 399 892 666 787 328 719 M18942 GO_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 8/22 Gene Ontology MF GO:0016502 0.304564623548234 0.450481436759446 540 601.545454545455 635 0.0356699995773005 180 0.960186285948682 0.960186285948682 1 1.70332893208996 350 823 859 731 537 539 180 635 669 845 449 720 M18442 GO_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 75/156 Gene Ontology MF GO:0004386 0.513552897225792 0.660461572419779 820 616.818181818182 636 0.0634117762979133 270 0.635897419203641 -0.635897419203641 -1 0.586798130016411 276 818 594 851 819 270 636 503 882 688 448 721 M17898 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 30/65 Gene Ontology MF GO:0016627 0.417759057244943 0.56603583603144 640 633.363636363636 637 0.0479808074722395 203 0.309763013129435 -0.243965297628089 -1 0.392159093978419 637 699 486 674 875 894 203 522 555 512 910 722 M18281 GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within. 4/13 Gene Ontology MF GO:0044213 0.844526004969434 0.945211587070412 490 627.818181818182 638 0.16983240724115 413 0.263440165376829 -0.134856366193812 -1 0.0330211979000769 488 695 704 739 865 561 413 424 846 638 533 723 M18427 GO_MISMATCHED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCHED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. 6/14 Gene Ontology MF GO:0030983 0.168233139357792 0.289298108802184 440 565.727272727273 639 0.0182516923158981 184 0.240401327671074 -0.281812118875063 -1 0.663297844343994 438 851 738 830 443 306 639 184 751 684 359 724 M18913 GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY.html Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 11/62 Gene Ontology MF GO:0008227 0.152583585489801 0.278525592560748 430 582.818181818182 639 0.0149384852436088 168 0.858982002181133 0.858982002181133 1 2.44255394720109 426 748 397 811 788 689 517 168 390 838 639 725 M18956 GO_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_BINDING.html Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 239/607 Gene Ontology MF GO:0003682 0.120253595333807 0.231935655570445 915 636.909090909091 640 0.0115798486558693 230 1.09551110190537 1.10466620513882 1 3.56123523448142 911 844 308 877 230 428 897 916 524 431 640 726 M18628 GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 32/82 Gene Ontology MF GO:0005089 0.0839184282471183 0.184260033382694 645 472.090909090909 643 0.00793650793650794 47 1.21732267203428 -1.00808656414928 -1 4.58036204061588 643 224 247 65 776 679 722 800 47 129 861 727 M17900 GO_QUINONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_BINDING.html Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. 12/20 Gene Ontology MF GO:0048038 0.550769746213977 0.693171226425252 515 627.909090909091 644 0.0701641801203609 187 0.455728234388246 -0.324006128845276 -1 0.371535113885067 876 664 187 644 511 749 635 626 699 514 802 728 M18300 GO_AMINOACYL_TRNA_EDITING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOACYL_TRNA_EDITING_ACTIVITY.html The hydrolysis of an incorrectly aminoacylated tRNA. 7/11 Gene Ontology MF GO:0002161 0.8904762546915 0.984073429205767 655 625.272727272727 644 0.198412698412698 437 0.204108888889835 -0.196759151156561 -1 0.00728959513894188 652 437 706 543 598 602 631 717 657 644 691 729 M18734 GO_ENDONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. 61/143 Gene Ontology MF GO:0004519 0.385458678901758 0.532465442326753 730 592.636363636364 644 0.0432964801647678 382 1.28885927361128 1.28885927361128 1 1.80698882637938 730 657 502 710 382 391 679 903 507 414 644 730 M18301 GO_FOLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_BINDING.html Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 7/12 Gene Ontology MF GO:0005542 0.0379290536545074 0.125520609216355 685 494.454545454545 645 0.00385924213350592 23 0.715201677855172 -0.681614090665719 -1 3.30181115165472 684 240 707 299 129 653 893 466 23 645 700 731 M18802 GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. 23/61 Gene Ontology MF GO:0005548 0.557443745451391 0.697752715394939 670 619 645 0.0714285714285714 330 1.30774781221536 1.30774781221536 1 1.04698450794785 667 608 330 491 708 844 781 645 465 396 874 732 M18051 GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. 2/11 Gene Ontology MF GO:0019203 0.0643018364747217 0.175480913493876 640 600 646 0.0073575033385932 179 0.485211007839317 -0.327005851364202 -1 1.87837338413977 636 384 652 NA 179 865 640 675 690 566 713 733 M18553 GO_ION_CHANNEL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_CHANNEL_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. 68/168 Gene Ontology MF GO:0044325 0.522804014301227 0.666139416110226 830 583.727272727273 646 0.0650451980285099 191 1.02713171569498 1.06997747004773 1 0.928265244628977 827 757 191 538 427 646 734 501 667 336 797 734 M18621 GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR.html Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. 6/11 Gene Ontology MF GO:0016884 0.108628386631304 0.218205492796506 485 619.272727272727 646 0.0114335211653946 149 0.285494544226924 -0.339453420094129 -1 0.966827629662128 485 917 779 646 717 608 905 149 319 738 549 735 M18444 GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 2/15 Gene Ontology MF GO:0005247 0.489743671752791 0.640234653089169 525 554.7 646.5 0.0720340424737612 247 0.245422324739313 -0.245422324739313 -1 0.243454154454328 525 649 741 NA 691 345 247 644 701 689 315 736 M18310 GO_TOXIC_SUBSTANCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIC_SUBSTANCE_BINDING.html Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems. 3/17 Gene Ontology MF GO:0015643 0.50230121620797 0.652707795072503 730 540.181818181818 648 0.0673973225666716 235 0.392958307116906 0.392958307116906 1 0.372940258580801 292 728 711 728 662 334 235 402 849 648 353 737 M18450 GO_LAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMIN_BINDING.html Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. 12/29 Gene Ontology MF GO:0005521 0.52349869331271 0.666139416110226 775 612.181818181818 649 0.0651690129178043 379 0.311791862136535 -0.432435149827577 -1 0.281780267654564 775 800 464 802 429 649 603 379 665 690 478 738 M18674 GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate into, out of or within a cell, or between cells. 23/47 Gene Ontology MF GO:1901476 0.178900911721313 0.304230755607409 865 602.454545454545 649 0.0177596312403622 114 0.717301207645577 -0.717301207645577 -1 1.89881658148639 861 414 114 549 396 451 730 917 785 761 649 739 M18057 GO_C2H2_ZINC_FINGER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_C2H2_ZINC_FINGER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. 7/22 Gene Ontology MF GO:0070742 0.78874632569501 0.895860024246184 550 630 650 0.143986868117331 345 0.33612720043743 0.438663928146564 1 0.0822294543257736 549 562 654 737 751 650 345 742 813 569 558 740 M18616 GO_METAL_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_CLUSTER_BINDING.html Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. 36/69 Gene Ontology MF GO:0051540 0.912058668480134 0.999999414526698 835 657.363636363636 650 0.198289542035697 461 0.762661991686792 -0.762661991686792 -1 8.54335820763325e-07 552 831 531 834 806 461 650 509 800 736 521 741 M18987 GO_2_IRON_2_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_IRON_2_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. 12/29 Gene Ontology MF GO:0051537 0.757849776225024 0.870439193666694 505 655.636363636364 650 0.120961865895363 360 0.227042972341971 -0.242143403108917 -1 0.0700824355361713 650 612 505 741 920 360 502 713 825 857 527 742 M18015 GO_I_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_SMAD_BINDING.html Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. 10/18 Gene Ontology MF GO:0070411 0.391694229797026 0.539459118882131 815 650.363636363636 651 0.0441830640033986 383 0.326293782646804 -0.27934527834116 -1 0.447994043610023 812 627 448 593 383 674 855 658 651 547 906 743 M17993 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 12/39 Gene Ontology MF GO:0001205 0.46961066541455 0.621642895225016 790 602.363636363636 653 0.0560191979634475 250 0.653874098340854 0.653874098340854 1 0.691495756082376 498 790 250 679 775 788 584 290 778 541 653 744 M18141 GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. 5/14 Gene Ontology MF GO:0015172 0.11162373771239 0.222281036137228 655 525.454545454545 653 0.0117662208924477 113 0.606521418004051 0.697463928642748 1 2.02901748864574 653 113 672 250 233 705 822 740 329 593 670 745 M18564 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). 9/21 Gene Ontology MF GO:0016755 0.090174594577888 0.193516954120293 145 524.454545454545 653 0.00940574266715293 113 0.874649861425705 -0.874649861425705 -1 3.19562974818567 306 653 770 669 835 141 144 612 805 721 113 746 M18321 GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. 25/81 Gene Ontology MF GO:0004715 0.963482732235963 0.999999414526698 655 644.181818181818 654 0.259852928565262 325 0.335165558339283 -0.337561652718634 -1 2.97553253547507e-07 867 651 325 717 639 533 483 778 776 654 663 747 M18962 GO_MAP_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_ACTIVITY.html Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. 9/17 Gene Ontology MF GO:0004708 0.934081566336537 0.999999414526698 750 678.090909090909 654 0.238095238095238 535 0.258402292162816 -0.249557443636033 -1 1.9757476232379e-07 746 535 862 560 654 543 889 580 694 850 546 748 M19024 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. 25/65 Gene Ontology MF GO:0016860 0.514011397665828 0.660461572419779 805 620.545454545455 654 0.0634920634920635 404 1.04262490393031 -0.794608618790592 -1 0.962121219529492 803 795 426 763 724 453 733 654 450 404 621 749 M17868 GO_IMMUNOGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_BINDING.html Interacting selectively and non-covalently with an immunoglobulin. 4/24 Gene Ontology MF GO:0019865 0.965362243138715 0.999999414526698 645 680.090909090909 656 0.285577743158748 502 0.211211777136164 0.174648635103528 1 1.36112597834998e-07 642 648 610 766 670 656 507 853 895 502 732 750 M19222 GO_SNORNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_BINDING.html Interacting selectively and non-covalently with small nucleolar RNA. 18/31 Gene Ontology MF GO:0030515 0.917817893933963 0.999999414526698 650 717.909090909091 656 0.203210893525177 566 0.198470066018506 -0.232147960429594 -1 1.19517459084344e-07 647 887 566 863 595 645 719 586 814 919 656 751 M18205 GO_SINGLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with single-stranded RNA. 52/138 Gene Ontology MF GO:0003727 0.336119305823773 0.482081651918856 650 639.818181818182 657 0.0365562422934233 208 1.29644110978073 1.29644110978073 1 2.10430345312529 649 906 477 899 657 208 823 744 787 462 426 752 M18339 GO_EXORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXORIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. 21/34 Gene Ontology MF GO:0004532 0.751985672431077 0.866950900547106 555 646.181818181818 658 0.119047619047619 376 1.35593454827845 1.35593454827845 1 0.430655883384723 823 577 457 658 827 553 806 688 554 376 789 753 M19207 GO_ACYL_COA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. 11/19 Gene Ontology MF GO:0003995 0.0804840350381173 0.184260033382694 320 546.454545454545 658 0.00759896913254519 116 0.320852188432148 -0.33496816434933 -1 1.20725514583584 316 658 440 673 876 198 863 116 720 917 234 754 M18062 GO_PRENYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRENYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). 7/16 Gene Ontology MF GO:0004659 0.798427306171539 0.904266869704602 660 703.090909090909 659 0.14799298611202 541 0.163513188040943 0.12961489940765 1 0.0366039342800116 830 659 656 637 541 818 673 584 854 570 912 755 M18456 GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. 90/211 Gene Ontology MF GO:0004721 0.251219871289126 0.387139500144047 660 622.818181818182 659 0.0259580429791353 325 0.903622821473322 0.903622821473322 1 1.90759263671314 659 668 530 752 325 849 465 535 717 481 870 756 M18590 GO_NEUROPILIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPILIN_BINDING.html Interacting selectively and non-covalently with a member of the neuropilin family. 6/15 Gene Ontology MF GO:0038191 0.760096287538194 0.871677951962191 660 664.818181818182 660 0.13303074433275 393 0.359133799123804 -0.353820692064182 -1 0.109719455767493 699 628 775 657 646 563 766 393 798 728 660 757 M18908 GO_POLY_A_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_RNA_BINDING.html Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. 700/1614 Gene Ontology MF GO:0044822 0.629731572196229 0.762306640027014 450 653.727272727273 660 0.0945766961549261 328 1.08501483481499 1.35841449033606 1 0.655090892938685 447 920 847 900 660 328 810 630 689 493 467 758 M17960 GO_SYNTAXIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_BINDING.html Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. 48/123 Gene Ontology MF GO:0019905 0.718347059816643 0.835641725586387 805 617.909090909091 661 0.108802363026396 386 1.53334444632203 1.53334444632203 1 0.612468564463905 802 715 469 666 505 386 732 812 661 453 596 759 M19203 GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. 8/13 Gene Ontology MF GO:0046030 0.949730866258267 0.999999414526698 470 682.818181818182 662 0.258467585323186 468 0.230869377602397 0.193306834354825 1 1.61715172263953e-07 468 654 915 558 755 699 662 515 736 916 633 760 M17851 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. 12/27 Gene Ontology MF GO:0016814 0.976364191554325 0.999999414526698 645 662.636363636364 663 0.288552644777012 347 0.260705052101151 -0.312514575041335 -1 2.0057393726452e-07 641 888 347 862 811 588 511 663 795 497 686 761 M17850 GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 28/77 Gene Ontology MF GO:0004712 0.994017380073136 0.999999414526698 610 662.909090909091 664 0.37208736895783 461 0.288220000325557 -0.256268048676281 -1 2.3641012749711e-07 856 606 461 664 815 685 599 609 780 496 721 762 M18375 GO_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOXYGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. 39/89 Gene Ontology MF GO:0051213 0.465091204827941 0.619163808606206 765 597.727272727273 664 0.0552907709792481 295 1.8636644772713 1.8636644772713 1 1.98746009181575 763 697 295 762 406 463 729 664 439 437 920 763 M18687 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. 19/37 Gene Ontology MF GO:0032266 0.684700795693125 0.809671892079273 545 601.909090909091 664 0.0996127173722526 350 1.48454799448882 1.48454799448882 1 0.697239794566506 542 669 433 750 700 806 787 350 552 368 664 764 M17896 GO_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVITY.html Catalysis of the reaction: GTP + H2O = GDP + phosphate. 129/266 Gene Ontology MF GO:0003924 0.63389956273523 0.763334551984831 880 660.272727272727 666 0.0873015873015873 458 1.0740690157583 1.0740690157583 1 0.645262547946257 880 729 495 818 496 482 885 846 508 458 666 765 M18591 GO_PEPTIDE_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen peptide. 23/62 Gene Ontology MF GO:0042605 0.924252772910931 0.999999414526698 670 701 666 0.209095131299749 274 0.257835397541898 -0.243187562589408 -1 1.9683642390093e-07 666 869 274 898 613 591 888 651 873 729 659 766 M18364 GO_DIACYLGLYCEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_BINDING.html Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. 6/14 Gene Ontology MF GO:0019992 0.336933154547635 0.482081651918856 690 634.454545454545 667 0.0402552805456004 254 0.46478231567647 -0.235587107428955 -1 0.754405972528181 690 461 723 476 909 764 628 254 663 667 744 767 M18414 GO_STEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 6/25 Gene Ontology MF GO:0015248 0.105684475103277 0.215586955864779 860 625.545454545455 667 0.0111075139192399 220 0.430459045465051 -0.323103647712212 -1 1.46931101342219 859 460 735 486 220 377 872 885 641 679 667 768 M17863 GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate from one side of the membrane to the other. 15/38 Gene Ontology MF GO:1901677 0.415320710913563 0.565001584554032 670 615.818181818182 668 0.0476190476190476 408 0.333619522009203 -0.314707682982354 -1 0.423718679631045 858 490 459 417 668 668 788 726 408 501 791 769 M17963 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. 14/28 Gene Ontology MF GO:0052866 0.966023779029219 0.999999414526698 525 661.090909090909 668 0.264690018881906 520 0.211063631422307 -0.232140730448208 -1 1.35919648971689e-07 770 784 524 681 871 525 563 520 833 533 668 770 M18112 GO_POLY_PYRIMIDINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PYRIMIDINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. 11/26 Gene Ontology MF GO:0008187 0.97983571324682 0.999999414526698 670 696.818181818182 670 0.298752752606054 437 0.195550573877104 -0.228073870894461 -1 1.15715035946617e-07 670 897 437 886 762 545 795 662 839 583 589 771 M18145 GO_ADRENERGIC_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an adrenergic receptor. 7/30 Gene Ontology MF GO:0031690 0.952012952007826 0.999999414526698 775 673.727272727273 674 0.261904761904762 478 0.650112755713168 -0.650112755713168 -1 7.07748743877392e-07 772 601 674 478 738 792 553 886 709 595 613 772 M18239 GO_ANDROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an androgen receptor. 29/64 Gene Ontology MF GO:0050681 0.597318307603006 0.737627977174182 675 615.818181818182 675 0.0793650793650794 306 1.31739699471586 1.31739699471586 1 0.891839775017645 675 468 396 306 799 682 790 919 493 416 830 773 M18458 GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. 5/19 Gene Ontology MF GO:0005229 0.196750683915374 0.325558685615367 825 604.181818181818 675 0.0216707539920851 206 0.375831022755579 -0.301212212982784 -1 0.938239232553586 824 431 745 474 303 897 489 206 675 694 908 774 M19013 GO_ENDORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. 26/63 Gene Ontology MF GO:0004521 0.775485941583084 0.882979042396581 735 660.090909090909 675 0.126984126984127 406 1.35593454827845 1.35593454827845 1 0.375398630215749 732 720 476 706 652 675 784 646 572 406 892 775 M18902 GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). 2/13 Gene Ontology MF GO:0005451 0.524897848655271 0.666997266247029 570 663.2 676.5 0.0793650793650794 302 0.221934289015334 -0.321147862577442 -1 0.199936529772732 766 302 845 NA 567 567 835 848 482 833 587 776 M18401 GO_FATTY_ACID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORTER_ACTIVITY.html Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 5/20 Gene Ontology MF GO:0015245 0.93188759655886 0.999999414526698 540 667.181818181818 677 0.235596581637722 494 0.438118258810525 -0.288055919356461 -1 4.31641550896136e-07 540 703 732 514 834 494 873 617 802 677 553 777 M18405 GO_NUCLEOSIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. 7/14 Gene Ontology MF GO:0019206 0.651612709342061 0.780577724732677 620 615.818181818182 678 0.100075179013173 357 0.191090937863515 -0.192279398148309 -1 0.105304804132287 619 753 733 718 712 393 446 485 880 678 357 778 M18068 GO_PROTEIN_KINASE_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_BINDING.html Interacting selectively and non-covalently with any subunit of protein kinase A. 18/48 Gene Ontology MF GO:0051018 0.953879836223368 0.999999414526698 680 715.181818181818 680 0.243976089517874 483 0.283162336528082 -0.235272261194398 -1 2.29822893514311e-07 680 644 483 677 622 904 825 832 757 572 871 779 M18087 GO_HISTONE_DEACETYLASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone deacetylase. 67/158 Gene Ontology MF GO:0042826 0.607090415480585 0.744697576322851 780 620.272727272727 680 0.0814188879273251 352 1.16960044627175 1.16960044627175 1 0.766967693168583 543 763 352 776 459 835 423 789 680 427 776 780 M18785 GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. 73/147 Gene Ontology MF GO:0008757 0.262538897518859 0.399510263186311 355 592.272727272727 681 0.0273058958160147 180 0.245176689304968 -0.26086584618189 -1 0.500424459851734 353 880 575 847 745 180 740 477 681 792 245 781 M18931 GO_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVITY.html Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. 8/35 Gene Ontology MF GO:0004629 0.0860151253550561 0.187521126366473 790 651.090909090909 681 0.00895379946158468 96 0.330654576304791 0.343971127104617 1 1.2312337377222 621 786 855 590 681 549 96 786 649 843 706 782 M17873 GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. 208/483 Gene Ontology MF GO:0019787 0.0968757913971404 0.203019881743438 750 625.727272727273 683 0.00922042728712949 95 0.955580469056208 1.0472256271066 1 3.38941255498048 750 878 595 868 787 95 771 683 645 491 320 783 M17995 GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 4/15 Gene Ontology MF GO:0001608 0.946700931645758 0.999999414526698 685 672.727272727273 683 0.254114848262382 476 0.330507977268644 -0.262922539559663 -1 2.91487097801552e-07 586 825 633 764 699 683 476 685 831 542 676 784 M18140 GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). 5/20 Gene Ontology MF GO:0015299 0.878423345409431 0.974157093212152 820 644 683 0.19 268 0.312701693216811 0.168498295468388 1 0.0182132432015194 820 268 671 325 874 711 845 556 683 592 739 785 M18727 GO_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. 43/87 Gene Ontology MF GO:0008094 0.861267122054875 0.96048814668402 685 655 684 0.164365602491874 419 0.635897419203641 -0.635897419203641 -1 0.0570274433764013 487 687 516 684 774 419 684 709 877 775 593 786 M18654 GO_GLUCURONOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. 7/36 Gene Ontology MF GO:0015020 0.214139132665174 0.343818502708482 580 628.090909090909 685 0.0238095238095238 271 0.371213556789536 -0.214696250397249 -1 0.881647669279858 580 459 792 375 624 771 904 695 271 753 685 787 M18520 GO_SUMO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_BINDING.html Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. 6/17 Gene Ontology MF GO:0032183 0.673486813722964 0.799494024032422 500 635.818181818182 686 0.105891811071627 352 0.238306502763663 -0.313878531526902 -1 0.118630191354733 500 909 760 883 686 352 492 362 861 708 481 788 M18267 GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY.html Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. 7/26 Gene Ontology MF GO:0004012 0.0765897756730953 0.184260033382694 155 555.818181818182 688 0.00793650793650794 152 1.30774781221536 1.30774781221536 1 4.9206004192189 711 401 701 152 881 832 688 560 153 212 823 789 M18435 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a functional group from one position to another within a single molecule. 13/27 Gene Ontology MF GO:0016866 0.0839184282471183 0.184260033382694 690 603.636363636364 688 0.00793650793650794 45 1.70956702222945 1.70956702222945 1 6.43250646916215 688 731 491 575 676 799 727 831 45 314 763 790 M18644 GO_GABA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. 7/25 Gene Ontology MF GO:0050811 0.692428060736338 0.81566429689812 395 610.363636363636 688 0.111219185759046 367 0.182548844292766 0.157106947219072 1 0.0827421919816031 404 916 789 796 688 395 394 367 753 750 462 791 M18911 GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. 10/74 Gene Ontology MF GO:0005230 0.878859116702268 0.974157093212152 635 703.272727272727 689 0.174603174603175 385 0.960186285948682 0.960186285948682 1 0.0559261325038517 623 762 385 631 671 851 689 900 635 837 752 792 M18113 GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. 15/37 Gene Ontology MF GO:0045309 0.961295376881107 0.999999414526698 530 680.272727272727 690 0.255928270884688 528 0.199386349081858 -0.231611989581989 -1 1.20710850178427e-07 769 833 528 690 730 594 811 566 848 584 530 793 M18939 GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. 6/28 Gene Ontology MF GO:0030898 0.649139793881337 0.77888441332192 410 639.636363636364 690 0.0994384275000491 335 0.56053187398179 -0.653939947519498 -1 0.311601446049892 407 862 858 781 870 335 690 388 567 844 434 794 M19113 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_.html Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. 7/19 Gene Ontology MF GO:0042800 0.410325839877151 0.560088683511838 895 619.454545454545 692 0.0514478566333727 261 0.141607968959629 -0.142720692531466 -1 0.182602497950042 517 749 895 707 692 316 667 306 812 892 261 795 M18798 GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. 10/16 Gene Ontology MF GO:0004549 0.949776431494504 0.999999414526698 900 712.272727272727 693 0.238095238095238 510 0.183942592703076 -0.184942533112783 -1 1.00596496810141e-07 898 510 590 567 673 690 840 766 693 797 811 796 M19142 GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 23/47 Gene Ontology MF GO:0016796 0.602641860084026 0.741217261065915 410 645.090909090909 694 0.0804782414455422 303 0.209847255625685 -0.232545893985515 -1 0.139794396468532 410 892 550 843 694 303 570 724 806 898 406 797 M17940 GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. 19/38 Gene Ontology MF GO:0004003 0.988245472598089 0.999999414526698 695 712.636363636364 695 0.332326550411026 527 0.213872241502343 -0.207559467113784 -1 1.39577656404465e-07 695 722 558 758 916 574 686 849 876 527 678 798 M18473 GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. 9/55 Gene Ontology MF GO:0005231 0.900849582143098 0.99136556886561 700 680.090909090909 696 0.206349206349206 460 0.960186285948682 0.960186285948682 1 0.0185230971352403 460 815 748 696 781 847 471 704 660 696 603 799 M19179 GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_.html Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. 9/15 Gene Ontology MF GO:0031078 0.760823255897434 0.871677951962191 910 709.636363636364 696 0.133293816668458 528 0.270962531386352 0.285304515272667 1 0.082782097636062 691 600 908 537 528 759 709 696 629 906 843 800 M19144 GO_RNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. 22/44 Gene Ontology MF GO:0034062 0.698152987361708 0.816138180905682 485 678.727272727273 697 0.103174603174603 390 1.07643464219997 1.07643464219997 1 0.486515241944861 482 886 593 861 697 801 682 795 533 390 746 801 M19061 GO_GAMMA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_CATENIN_BINDING.html Interacting selectively and non-covalently with the gamma subunit of the catenin complex. 7/21 Gene Ontology MF GO:0045295 0.0478162936522457 0.147127057391525 700 651.181818181818 698 0.00488774530227117 99 0.376897651325055 0.376243356706393 1 1.60682572120951 698 480 884 379 698 825 751 99 648 879 822 802 M19082 GO_MONOSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 36/85 Gene Ontology MF GO:0048029 0.492025631174306 0.641166544873033 850 646.727272727273 698 0.0597175172030309 173 1.8636644772713 1.8636644772713 1 1.84268959737345 850 698 173 569 725 537 815 783 652 430 882 803 M18253 GO_CAMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BINDING.html Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). 6/29 Gene Ontology MF GO:0030552 0.936927851860616 0.999999414526698 630 696.272727272727 699 0.241450786722117 461 0.261423747497158 -0.204268037592379 -1 2.01509984998303e-07 627 807 699 804 853 520 461 842 872 629 545 804 M18492 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein receptor. 8/20 Gene Ontology MF GO:0050750 0.393716141734288 0.540553840032558 885 641.272727272727 700 0.0488092887601852 391 0.360267647336362 -0.408414651469718 -1 0.493014702114842 882 614 753 459 391 483 741 700 600 701 730 805 M18671 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. 9/29 Gene Ontology MF GO:0016701 0.891014311443917 0.984073429205767 700 698.090909090909 700 0.198807367089797 421 0.491305443275731 -0.573965652667059 -1 0.0175467991801117 764 700 795 699 689 615 421 814 745 760 677 806 M18689 GO_CHOLESTEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 4/18 Gene Ontology MF GO:0017127 0.528564943523023 0.669806815483721 680 644.090909090909 700 0.0724396251594961 301 0.552655726898759 -0.460141612826786 -1 0.492709880000429 679 301 798 433 447 700 791 706 647 765 818 807 M18984 GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON.html The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 53/144 Gene Ontology MF GO:0005200 0.203933615157807 0.332657670115571 885 674.272727272727 701 0.0205204126562783 119 0.851637524434599 -0.778505303076792 -1 2.08519410858597 885 677 119 520 823 583 920 701 542 855 792 808 M18133 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY.html Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. 8/13 Gene Ontology MF GO:0034595 0.991183884964979 0.999999414526698 830 719.454545454545 702 0.376943078641599 580 0.287231382333956 0.204458861258033 1 2.35122525495267e-07 887 615 669 580 702 755 827 618 829 590 842 809 M18048 GO_UNFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with an unfolded protein. 55/120 Gene Ontology MF GO:0051082 0.600291268580498 0.739314547649342 535 658.272727272727 703 0.0799850682990229 301 0.262883999476283 -0.282562123542249 -1 0.176629160926387 534 882 481 867 812 301 816 703 762 563 520 810 M18511 GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING.html Interacting selectively and non-covalently with any part of the small ribosomal subunit. 9/22 Gene Ontology MF GO:0043024 0.804956120936968 0.909778416783796 720 665.636363636364 704 0.150793650793651 410 0.331224631448111 0.309607966605388 1 0.0696704357626748 718 520 757 582 749 786 410 631 603 704 862 811 M19005 GO_P53_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_P53_BINDING.html Interacting selectively and non-covalently with one of the p53 family of proteins. 49/92 Gene Ontology MF GO:0002039 0.485800540558366 0.637294912097509 730 631.545454545455 705 0.0586757698297435 323 0.292793352255742 -0.30457013584844 -1 0.293442931656929 727 758 454 809 415 323 627 705 765 865 499 812 M18570 GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. 38/83 Gene Ontology MF GO:0004843 0.874776060797914 0.9731487012504 910 665.545454545455 710 0.172112017837006 432 1.48034281358945 1.48034281358945 1 0.0896333903278204 906 719 478 746 566 710 536 821 674 432 733 813 M18703 GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 24/96 Gene Ontology MF GO:0005249 0.161385165508919 0.28120142475039 785 601.727272727273 710 0.0158730158730159 201 1.48119732015779 -1.42279293755586 -1 4.18034662680597 785 710 262 573 727 914 537 775 244 201 891 814 M18343 GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE.html The action of a molecule that contributes to the structural integrity of the nuclear pore complex. 6/14 Gene Ontology MF GO:0017056 0.993625729760029 0.999999414526698 740 707.181818181818 711 0.396825396825397 512 0.239723278327767 -0.269460906509911 -1 1.73246724789768e-07 740 512 719 626 760 666 916 689 779 661 711 815 M19035 GO_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glutamate receptor. 21/50 Gene Ontology MF GO:0035254 0.698152987361708 0.816138180905682 755 651 711 0.103174603174603 302 1.05092712200537 -1.24287224182961 -1 0.474986626627873 753 711 302 516 616 871 754 838 530 380 890 816 M18313 GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. 6/21 Gene Ontology MF GO:0004303 0.962978599136008 0.999999414526698 715 713.545454545455 712 0.280807276366414 543 0.203625448502261 -0.157037189015779 -1 1.26231964447131e-07 602 770 712 815 860 643 714 543 906 649 635 817 M18566 GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. 13/29 Gene Ontology MF GO:0015665 0.0199163669990049 0.0934849879545127 895 594.454545454545 712 0.00182718059314948 62 0.544309219410051 -0.564983479860814 -1 2.86966745052595 895 340 62 524 469 828 712 462 756 722 769 818 M17991 GO_FATTY_ACYL_COA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_BINDING.html Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. 19/35 Gene Ontology MF GO:0000062 0.938394445493904 0.999999414526698 715 669.272727272727 713 0.223814647562591 497 0.19261666677187 -0.205808937042957 -1 1.11893838381918e-07 715 914 534 849 713 503 726 542 830 539 497 819 M18208 GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. 11/29 Gene Ontology MF GO:0005487 0.999290811864212 0.999999414526698 845 729.727272727273 713 0.482743940004112 560 0.185577919882591 -0.167809826255185 -1 1.02726389820284e-07 841 560 569 694 817 713 915 684 845 610 779 820 M17885 GO_OLFACTORY_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_RECEPTOR_ACTIVITY.html Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. 20/849 Gene Ontology MF GO:0004984 0.96444729857158 0.999999414526698 480 655.727272727273 714 0.261651926647062 349 0.822128263809292 0.822128263809292 1 9.31786253263671e-07 478 747 349 714 632 803 716 692 792 507 783 821 M18449 GO_ATPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_BINDING.html Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. 45/113 Gene Ontology MF GO:0051117 0.816521443770307 0.920587902290052 800 656.727272727273 715 0.142857142857143 321 1.17293302478051 1.17293302478051 1 0.215898189048806 798 738 321 715 901 479 669 774 592 352 885 822 M19119 GO_CADHERIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CADHERIN_BINDING.html Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. 11/34 Gene Ontology MF GO:0045296 0.756733739190157 0.87024380006868 805 648.545454545455 715 0.12059432924448 306 0.264993734939192 -0.276375413893841 -1 0.0819292447531891 645 803 306 754 908 358 324 715 801 893 627 823 M18541 GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. 12/25 Gene Ontology MF GO:0015035 0.383041679534718 0.530720399355332 615 644.363636363636 716 0.0429550239849779 267 0.252531253047749 0.264764751900555 1 0.355894413520438 613 801 416 755 593 845 468 267 871 716 743 824 M18943 GO_METHYL_CPG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYL_CPG_BINDING.html Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. 10/19 Gene Ontology MF GO:0008327 0.834612889148228 0.938684423002897 735 635.090909090909 716 0.150908102908712 384 0.192825907259809 0.214165654532466 1 0.0271423617480029 457 814 537 716 735 729 384 412 734 846 622 825 M18551 GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. 9/22 Gene Ontology MF GO:0004653 0.000753329667573137 0.0108291139713638 885 534 718 7.53585166997199e-05 12 0.792818209239797 -0.951227257522007 -1 7.98155890119598 881 147 768 131 12 756 777 621 327 718 736 826 M18859 GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. 7/39 Gene Ontology MF GO:0005251 0.0765897756730953 0.184260033382694 720 621.363636363636 719 0.00793650793650794 131 1.42279293755586 -1.42279293755586 -1 5.35347524621554 719 682 830 565 842 747 725 498 131 216 880 827 M19047 GO_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEAMINASE_ACTIVITY.html Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). 11/28 Gene Ontology MF GO:0019239 0.996437589602077 0.999999414526698 710 738.636363636364 719 0.400993868148842 447 0.19050773577582 -0.19504937446602 -1 1.09147111339386e-07 710 889 447 855 830 620 594 676 912 873 719 828 M19049 GO_THYROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a thyroid hormone receptor. 18/42 Gene Ontology MF GO:0046966 0.289091209412091 0.433165981529517 760 635.727272727273 719 0.0305430354489651 271 0.253400283125749 -0.2531071493649 -1 0.471616011668022 845 271 535 427 346 688 756 719 772 874 760 829 M19160 GO_EXODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. 7/19 Gene Ontology MF GO:0004529 0.615128449126795 0.750788045147226 905 625.636363636364 719 0.0910676076704982 341 0.228158146960183 -0.311260634170924 -1 0.145480905200741 391 874 903 744 719 364 412 484 748 902 341 830 M18344 GO_NUCLEOTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDASE_ACTIVITY.html Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. 7/15 Gene Ontology MF GO:0008252 0.921468113086315 0.999999414526698 750 734.454545454545 720 0.224637838325089 571 0.184119287304299 -0.207142569267855 -1 1.00826628493139e-07 749 910 720 873 607 571 593 813 897 662 684 831 M18875 GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. 6/13 Gene Ontology MF GO:0008484 0.00518047254343138 0.0397169561663072 700 553.818181818182 720 0.000519258909946698 38 0.653320054436723 0.653320054436723 1 4.68849183229274 697 230 836 211 38 780 743 893 119 825 720 832 M18922 GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING.html Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. 9/24 Gene Ontology MF GO:0031683 0.503769767583206 0.65369278727299 660 669.090909090909 720 0.0676728701321012 282 0.251066232165778 -0.291568884548433 -1 0.237434176785214 658 805 850 827 504 282 598 720 916 840 360 833 M18381 GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. 10/24 Gene Ontology MF GO:0005385 0.677091579943129 0.801704316020179 875 684.636363636364 722 0.097658665953392 299 0.331009082897351 0.311743305662228 1 0.162745140659492 872 804 299 722 490 774 569 792 684 674 851 834 M18860 GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. 11/18 Gene Ontology MF GO:0034979 0.604197622797557 0.742138602101138 905 680.545454545455 726 0.0808061137324886 458 0.278345511675885 0.242105400949818 1 0.184656879152301 902 611 507 468 458 769 902 796 528 819 726 835 M18814 GO_1_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 10/24 Gene Ontology MF GO:0005545 0.97530599069028 0.999999414526698 730 710 727 0.285714285714286 350 0.355024342290499 -0.323694669592312 -1 3.23417854623965e-07 883 692 350 730 783 667 773 680 727 803 722 836 M18592 GO_DYNEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_BINDING.html Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. 13/55 Gene Ontology MF GO:0045502 0.975951589406339 0.999999414526698 640 715.545454545455 730 0.287432460670591 467 0.230343274905734 -0.161173192846759 -1 1.61029962313138e-07 640 859 467 808 675 886 665 550 818 730 773 837 M18595 GO_RAGE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAGE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. 3/18 Gene Ontology MF GO:0050786 0.434002414016555 0.582893753131724 590 701.090909090909 731 0.0553270977417879 407 0.396361226134683 0.2154293740675 1 0.475915533419005 844 704 776 609 407 742 819 587 589 731 904 838 M19187 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 16/26 Gene Ontology MF GO:0016645 0.161385165508919 0.28120142475039 735 594.909090909091 731 0.0158730158730159 225 0.910320449599634 0.960048109696748 1 2.56917487607474 731 489 333 453 737 762 794 861 225 343 816 839 M18023 GO_CYTOSKELETAL_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. 6/18 Gene Ontology MF GO:0008093 0.924566932545693 0.999999414526698 735 716.636363636364 732 0.227753094235164 553 0.121305948204044 -0.136667247377289 -1 1.90168881737195e-08 786 842 641 732 610 782 555 768 883 553 731 840 M18636 GO_FOUR_WAY_JUNCTION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOUR_WAY_JUNCTION_DNA_BINDING.html Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. 7/18 Gene Ontology MF GO:0000400 0.96908319439447 0.999999414526698 735 706 732 0.293650793650794 601 0.30162170458153 -0.288624851914841 -1 2.5386485862148e-07 733 660 785 688 707 641 737 601 732 745 737 841 M19055 GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY.html Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. 9/40 Gene Ontology MF GO:0008329 0.838494417110154 0.939603975324412 760 701.090909090909 732 0.166666666666667 262 1.29644110978073 1.29644110978073 1 0.179665245251601 757 732 881 630 867 906 702 495 623 262 857 842 M18729 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. 94/232 Gene Ontology MF GO:0061659 0.915982306297955 0.999999414526698 920 737.181818181818 733 0.201609201084294 467 0.830667033865178 0.830667033865178 1 9.42907371340268e-07 916 912 588 895 733 467 857 682 728 776 555 843 M18898 GO_CULLIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). 7/16 Gene Ontology MF GO:0097602 0.989353804947997 0.999999414526698 740 714.272727272727 733 0.365079365079365 570 0.525602276263726 -0.525602276263726 -1 5.45583029767729e-07 739 733 843 570 747 639 623 727 763 831 642 844 M18280 GO_POLY_PURINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PURINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. 15/29 Gene Ontology MF GO:0070717 0.703652386499281 0.821523090836723 740 705.454545454545 736 0.104672449485405 338 0.245547111871026 -0.225243011030279 -1 0.107387359332189 736 853 450 840 789 338 711 912 862 637 632 845 M18641 GO_MHC_CLASS_I_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 22/68 Gene Ontology MF GO:0042288 0.932666129123056 0.999999414526698 785 688 736 0.217515433928569 378 0.27960488441958 -0.265638998038736 -1 2.25189574582947e-07 664 813 378 783 684 481 892 736 781 749 607 846 M18421 GO_ADENOSINE_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOSINE_DEAMINASE_ACTIVITY.html Catalysis of the reaction: adenosine + H2O = inosine + NH3. 6/10 Gene Ontology MF GO:0004000 0.187840740332002 0.314627548899387 780 680.454545454545 737 0.020590933487371 146 0.218275267306783 -0.219680170639541 -1 0.561494545508271 780 861 737 828 543 595 146 655 911 682 747 847 M18985 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. 9/17 Gene Ontology MF GO:0005337 0.513656593785075 0.660461572419779 920 713.181818181818 737 0.069547294108346 305 0.251844539414325 0.196410703747049 1 0.232398885333475 919 637 866 602 629 781 710 305 737 856 803 848 M17926 GO_UBIQUITIN_LIKE_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_BINDING.html Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. 76/151 Gene Ontology MF GO:0032182 0.616660252806322 0.750788045147226 745 641.272727272727 739 0.0834756945890606 309 1.48034281358945 1.48034281358945 1 0.94391451464827 744 756 556 773 778 309 884 677 739 477 361 849 M18648 GO_CARBON_SULFUR_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_SULFUR_LYASE_ACTIVITY.html Catalysis of the elimination of hydrogen sulfide or substituted H2S. 8/13 Gene Ontology MF GO:0016846 0.1397056594563 0.262304503468972 420 572.272727272727 740 0.0149354127863909 167 0.686007751272719 -0.686007751272719 -1 2.04226410166891 417 873 790 740 810 346 344 167 783 751 274 850 M18431 GO_OXYGEN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORTER_ACTIVITY.html Enables the directed movement of oxygen into, out of or within a cell, or between cells. 5/17 Gene Ontology MF GO:0005344 0.33296556889208 0.479387047544153 830 714.818181818182 741 0.0396825396825397 365 0.649696430990385 -0.54614124970488 -1 1.06264837177857 829 438 739 519 741 822 906 918 365 686 900 851 M18157 GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY.html Combining with a neuropeptide to initiate a change in cell activity. 3/49 Gene Ontology MF GO:0008188 0.999888441881325 0.999999414526698 860 765.363636363636 743 0.597514612010397 597 0.155495686299545 -0.15889054937554 -1 6.3546499801556e-08 853 743 678 705 857 719 721 860 901 597 785 852 M18452 GO_CYCLIC_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 9/43 Gene Ontology MF GO:0030551 0.954624081697439 0.999999414526698 695 748.181818181818 743 0.266022845016668 519 0.210375343815822 -0.171668681897542 -1 1.35023205140518e-07 694 855 743 841 844 519 634 899 893 692 616 853 M18633 GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. 12/21 Gene Ontology MF GO:0052745 0.686933745162942 0.811269634852256 685 724.363636363636 743 0.100194277721777 406 0.22709495984981 0.17443334151666 1 0.105662452613814 681 775 406 703 497 880 676 915 853 743 839 854 M18639 GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. 7/11 Gene Ontology MF GO:0051766 0.95194769385719 0.999999414526698 790 719.454545454545 743 0.261804448838046 486 0.206640056588002 0.228115149532362 1 1.30158269085476e-07 573 841 788 789 687 743 486 702 865 748 692 855 M18972 GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. 6/12 Gene Ontology MF GO:0004535 0.954099311045667 0.999999414526698 745 728.545454545455 743 0.265178388899586 518 0.221007195919451 -0.191900451772044 -1 1.48870408173685e-07 743 734 863 757 773 518 705 730 767 851 573 856 M18975 GO_DOUBLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with double-stranded RNA. 64/150 Gene Ontology MF GO:0003725 0.98814918110894 0.999999414526698 905 711.454545454545 746 0.331831165907296 430 1.29644110978073 1.29644110978073 1 1.54954374418698e-06 671 905 430 878 907 746 582 585 749 468 905 857 M18355 GO_PROTEIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of proteins into, out of or within a cell, or between cells. 51/119 Gene Ontology MF GO:0008565 0.729058246078197 0.844752627697659 750 652.545454545455 747 0.111938040907306 373 1.90919498657043 1.90919498657043 1 0.716540348624399 747 792 512 807 786 373 910 781 632 459 379 858 M18516 GO_HMG_BOX_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HMG_BOX_DOMAIN_BINDING.html Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. 9/22 Gene Ontology MF GO:0071837 0.356471372498304 0.504855532885815 630 682.454545454545 747 0.0431215208010998 381 0.452924660399146 0.585372444317946 1 0.688651478438454 628 532 759 505 381 775 870 808 747 707 795 859 M18045 GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. 7/13 Gene Ontology MF GO:0052744 0.999230228766435 0.999999414526698 685 742.545454545455 748 0.511756840054947 562 0.197311082030593 -0.133227362817833 -1 1.18007967940525e-07 685 752 649 678 748 738 812 877 843 562 824 860 M18330 GO_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. 42/81 Gene Ontology MF GO:0004527 0.162698985893687 0.282420881173947 895 621.090909090909 750 0.0160132783088836 264 1.33858766238171 1.58822337752214 1 3.76497739012673 893 751 435 767 264 592 793 750 444 345 798 861 M18866 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. 9/23 Gene Ontology MF GO:0016863 0.625757109735745 0.759494117357368 825 658.545454545455 751 0.0936094773113937 325 0.794608618790592 -0.794608618790592 -1 0.486288404604179 544 840 832 751 898 325 550 461 823 821 399 862 M18888 GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. 19/27 Gene Ontology MF GO:0003887 0.936989803160346 0.999999414526698 780 741.636363636364 752 0.222222222222222 484 0.839316232100865 -0.839316232100865 -1 9.5417231397456e-07 777 746 484 656 752 841 868 817 679 828 710 863 M18340 GO_LYSOZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOZYME_ACTIVITY.html Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3/15 Gene Ontology MF GO:0003796 0.998751755918249 0.999999414526698 745 774.090909090909 754 0.487575422669085 660 0.303639501280234 -0.303639501280234 -1 2.56492889964868e-07 741 827 718 822 743 691 886 754 903 660 770 864 M18809 GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING.html Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. 17/34 Gene Ontology MF GO:0001098 0.0667017769143903 0.179957873200115 610 647.181818181818 755 0.00625584930076202 165 0.955023857704091 0.955023857704091 1 3.64361488250723 606 848 554 799 165 837 447 763 544 801 755 865 M18804 GO_RETINOID_X_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOID_X_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a retinoid X receptor. 8/25 Gene Ontology MF GO:0046965 0.490614598291157 0.640234653089169 825 709.636363636364 757 0.0652302507124652 431 0.323763765853329 -0.184816076553412 -1 0.321167378843835 825 672 821 583 431 765 757 527 719 799 907 866 M18599 GO_CGMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BINDING.html Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). 4/19 Gene Ontology MF GO:0030553 0.958437053593386 0.999999414526698 760 745.272727272727 759 0.272436953620489 523 0.177845554128155 -0.18896239749136 -1 9.2655553856358e-08 759 778 778 791 843 523 758 673 907 733 655 867 M18314 GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY.html Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. 7/11 Gene Ontology MF GO:0005092 0.871521456237379 0.970701864090058 770 747.363636363636 761 0.185515056202707 582 0.245865896686427 -0.197216450393968 -1 0.016263782191438 846 768 713 770 582 663 761 845 878 650 745 868 M18872 GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a macromolecule from one side of the membrane to the other. 11/35 Gene Ontology MF GO:0022884 0.563849904474894 0.703856054432703 705 688 761 0.072658631899601 299 0.216130095675106 0.181532541961348 1 0.168846599683016 701 896 334 844 449 698 299 761 908 824 854 869 M19023 GO_C_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. 6/20 Gene Ontology MF GO:0016408 0.490461865262221 0.640234653089169 765 711.090909090909 762 0.0652022265573202 430 0.21956860743673 -0.231817832520851 -1 0.217807757024462 762 713 871 636 430 785 543 772 770 868 672 870 M18781 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. 9/20 Gene Ontology MF GO:0019198 0.0790540194863319 0.184260033382694 795 564.363636363636 763 0.00820157182874247 93 0.208294915724459 0.23379006373621 1 0.783741243735692 228 898 817 792 763 296 93 231 874 791 425 871 M18037 GO_FMN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FMN_BINDING.html Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 6/14 Gene Ontology MF GO:0010181 0.983908885653252 0.999999414526698 875 729.818181818182 764 0.338303843382913 557 0.366988023702445 -0.209195895899253 -1 3.38999667079651e-07 871 563 647 659 679 784 837 801 764 557 866 872 M19032 GO_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. 50/110 Gene Ontology MF GO:0004540 0.775485941583084 0.882979042396581 780 691.454545454545 764 0.126984126984127 457 1.35593454827845 1.35593454827845 1 0.375398630215749 778 798 523 833 764 470 900 847 575 457 661 873 M19136 GO_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. 28/60 Gene Ontology MF GO:0003678 0.999577531751928 0.999999414526698 760 779.545454545455 764 0.506537668103294 532 0.218023057819947 -0.238341867823453 -1 1.44983788444585e-07 702 764 532 760 913 677 808 882 885 896 756 874 M18477 GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 21/44 Gene Ontology MF GO:0046915 0.878859116702268 0.974157093212152 800 675.272727272727 765 0.174603174603175 351 1.03069309216194 -1.03069309216194 -1 0.0600328176784946 799 765 351 753 797 766 779 782 634 379 623 875 M17922 GO_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. 21/35 Gene Ontology MF GO:0034061 0.972114443288272 0.999999414526698 905 753.909090909091 766 0.277777777777778 485 0.839316232100865 -0.839316232100865 -1 9.5417231397456e-07 901 766 485 765 757 899 783 894 724 519 800 876 M17955 GO_DNA_SECONDARY_STRUCTURE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SECONDARY_STRUCTURE_BINDING.html Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. 11/27 Gene Ontology MF GO:0000217 0.999020906810645 0.999999414526698 795 734.363636363636 767 0.467354149398995 452 0.237996813907905 -0.247685894835343 -1 1.70998132247438e-07 794 871 452 825 767 657 879 741 826 531 735 877 M18319 GO_RRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. 7/16 Gene Ontology MF GO:0008649 0.997708344458937 0.999999414526698 915 781.818181818182 768 0.455478623208827 653 0.154927595004744 -0.151210776259644 -1 6.28066027992455e-08 915 876 715 800 726 732 768 671 886 653 858 878 M18240 GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other. 11/17 Gene Ontology MF GO:0042887 0.939725625463588 0.999999414526698 835 736.454545454545 770 0.22535455083448 282 0.318375091255833 0.29375038384585 1 2.75684908835782e-07 834 723 282 826 800 714 770 755 894 622 881 879 M18223 GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. 16/32 Gene Ontology MF GO:0015036 0.91826882701175 0.999999414526698 820 724.545454545455 772 0.203609341054956 404 0.262405482994366 0.222878785656766 1 2.02788623058935e-07 818 839 404 772 596 693 800 733 864 618 833 880 M19225 GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a nucleotidyl group to a reactant. 69/136 Gene Ontology MF GO:0016779 0.218373125191342 0.349397000306148 600 713.272727272727 772 0.0221490088254496 307 0.884805205055864 -0.788990486483808 -1 2.06976966861193 900 881 600 860 307 768 833 855 596 474 772 881 M18627 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. 8/22 Gene Ontology MF GO:0016864 0.929031629334995 0.999999414526698 795 728.636363636364 774 0.2324503403439 493 0.194155350746688 -0.232662213571798 -1 1.13897860747496e-07 774 791 782 769 793 610 851 493 856 742 554 882 M18373 GO_AMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BINDING.html Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. 4/11 Gene Ontology MF GO:0043176 0.959309138573982 0.999999414526698 815 755.636363636364 778 0.273978154705903 638 0.298731348099446 -0.363055868309938 -1 2.50100382530623e-07 811 638 726 778 644 680 864 902 793 670 806 883 M18901 GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING.html Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. 8/17 Gene Ontology MF GO:0043560 0.997474348288326 0.999999414526698 825 772.636363636364 779 0.450158714705526 667 0.231057213879606 -0.210879926602174 -1 1.6195981515798e-07 734 824 844 682 779 776 668 667 821 832 872 884 M18569 GO_MICROFILAMENT_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROFILAMENT_MOTOR_ACTIVITY.html Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 4/31 Gene Ontology MF GO:0000146 0.999934747140119 0.999999414526698 785 805.090909090909 782 0.618530381471051 723 0.152596443331686 -0.172298089011165 -1 5.97704497185485e-08 782 903 771 864 790 740 776 820 920 723 767 885 M17992 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. 5/10 Gene Ontology MF GO:0052629 0.940634982288152 0.999999414526698 785 743.181818181818 784 0.246031746031746 540 0.182004465676356 -0.131964900295157 -1 9.80722293371299e-08 784 726 631 572 824 796 877 830 696 540 899 886 M17852 GO_5_3_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_5_3_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. 4/12 Gene Ontology MF GO:0008409 0.973921254624366 0.999999414526698 875 760.090909090909 787 0.30556968832593 498 0.174363123376668 -0.201862107003751 -1 8.81199447080402e-08 862 787 609 771 664 875 854 668 900 498 873 887 M18655 GO_ANNEALING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANNEALING_ACTIVITY.html A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide. 7/15 Gene Ontology MF GO:0097617 0.999856702695053 0.999999414526698 745 786.727272727273 793 0.587310136123539 638 0.276382440377423 0.297573823602452 1 2.20992578943822e-07 638 808 793 742 869 773 820 745 891 754 821 888 M18187 GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. 6/18 Gene Ontology MF GO:0004550 0.999493225603366 0.999999414526698 725 778.090909090909 794 0.531746031746032 604 0.198997416360724 -0.301561679161598 -1 1.20204294001452e-07 839 724 683 743 895 724 829 883 841 604 794 889 M18612 GO_TRANSLATION_INITIATION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_BINDING.html Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. 15/32 Gene Ontology MF GO:0031369 0.697474364426441 0.816138180905682 825 749.090909090909 796 0.102991492587202 500 0.191189265782463 -0.179099129442585 -1 0.0864115341756317 836 821 581 824 500 721 796 865 811 735 750 890 M18682 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. 4/13 Gene Ontology MF GO:0050664 0.695928481447381 0.816138180905682 845 765.636363636364 797 0.112235909099259 508 0.278935370209605 -0.343691293837733 -1 0.126070077059732 918 727 797 709 508 816 841 674 827 764 841 891 M18036 GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY.html Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. 6/15 Gene Ontology MF GO:0034450 0.999942855853922 0.999999414526698 750 778.545454545455 798 0.623558777843715 556 0.190181853414722 -0.134893075616286 -1 1.08722673605013e-07 748 875 646 894 798 813 715 769 913 556 837 892 M17928 GO_RNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. 26/48 Gene Ontology MF GO:0008173 0.997496654955222 0.999999414526698 810 751.909090909091 799 0.419901312181212 521 0.170289770589259 -0.179304614385701 -1 8.28147032013679e-08 807 867 583 856 886 621 799 764 884 521 683 893 M18713 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. 19/43 Gene Ontology MF GO:0044390 0.929545109497602 0.999999414526698 635 753.272727272727 802 0.214285714285714 504 0.201127014565586 0.246085370883314 1 1.22977938558803e-07 635 894 504 875 915 802 844 547 671 772 827 894 M19000 GO_ANGIOTENSIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOTENSIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an angiotensin receptor. 7/21 Gene Ontology MF GO:0031701 0.999400475338339 0.999999414526698 885 774.181818181818 802 0.523809523809524 532 0.393706633173453 0.464042465325432 1 3.73798684833354e-07 884 602 867 532 802 795 694 785 840 862 853 895 M18737 GO_ANION_ANION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_ANION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). 4/29 Gene Ontology MF GO:0015301 0.542191720342787 0.683310113308718 840 743.363636363636 803 0.0751562536350936 315 0.258781833774682 -0.230442743774708 -1 0.219221803889526 838 826 803 795 862 584 834 315 838 778 704 896 M18886 GO_TRANSLATION_REPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REPRESSOR_ACTIVITY.html Antagonizes ribosome-mediated translation of mRNA into a polypeptide. 7/22 Gene Ontology MF GO:0030371 0.52966595928217 0.670278793039334 610 739 803 0.0726564807928223 448 0.293026681060512 0.293094859662465 1 0.260783225030249 608 521 840 747 448 814 898 859 803 827 764 897 M18817 GO_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_A2_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. 7/33 Gene Ontology MF GO:0004623 0.278549659544236 0.4187347823214 520 693.181818181818 805 0.0321219423407643 177 0.148828341678598 0.15768023047143 1 0.288209882405164 518 860 824 854 894 558 177 759 910 805 466 898 M19112 GO_TRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. 13/20 Gene Ontology MF GO:0008175 0.942212420465549 0.999999414526698 880 749.818181818182 805 0.228315991748016 504 0.19544759146627 -0.19465339436183 -1 1.15580908953712e-07 735 785 506 805 880 589 859 815 879 891 504 899 M18751 GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY.html Combining with a protein hormone to initiate a change in cell activity. 3/23 Gene Ontology MF GO:0016500 0.97805785598086 0.999999414526698 905 786.090909090909 808 0.317460317460317 544 0.312286117093397 -0.210966896946887 -1 2.67754469184334e-07 817 705 808 544 771 905 846 826 740 782 903 900 M18976 GO_MHC_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 28/83 Gene Ontology MF GO:0042287 0.895427102099553 0.987761311668571 810 725.363636363636 809 0.18556526866574 267 0.272562416327487 -0.247493603556465 -1 0.00746637713127184 809 884 267 865 677 510 909 693 867 852 646 901 M18807 GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in). 2/12 Gene Ontology MF GO:0043225 0.991716441041842 0.999999414526698 790 780.1 815.5 0.412928802019035 486 0.375693296144532 -0.24765485583465 -1 3.50337642231079e-07 788 486 822 NA 868 846 605 881 809 800 896 902 M19012 GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. 7/20 Gene Ontology MF GO:0008353 0.466391868874023 0.619163808606206 870 773.727272727273 822 0.0608775040163223 419 0.176844322572936 -0.195845651714247 -1 0.188591242382002 910 647 870 695 419 708 896 822 881 867 796 903 M18064 GO_LYSINE_ACETYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_ACETYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. 6/21 Gene Ontology MF GO:0070577 0.973352505806809 0.999999414526698 670 759.090909090909 825 0.304069873001783 523 0.107633376683514 -0.0680474285248005 -1 1.20937241965383e-09 669 902 657 850 899 888 523 649 917 571 825 904 M18842 GO_MYOSIN_V_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_V_BINDING.html Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. 9/22 Gene Ontology MF GO:0031489 0.998425197854245 0.999999414526698 700 797.818181818182 827 0.475527646971314 661 0.252452862196172 0.180980280516218 1 1.89826068692921e-07 912 872 827 832 848 661 697 699 836 814 778 905 M18318 GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. 6/11 Gene Ontology MF GO:0008568 0.615061865740947 0.750788045147226 920 754.181818181818 828 0.0910518842206722 273 0.118644696663609 -0.065063499801882 -1 0.0756515727279817 737 918 714 891 617 909 273 839 918 652 828 906 M19161 GO_4_IRON_4_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_IRON_4_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. 25/42 Gene Ontology MF GO:0051539 0.999590520100346 0.999999414526698 835 788.272727272727 828 0.507936507936508 542 0.839316232100865 -0.839316232100865 -1 9.5417231397456e-07 835 891 542 888 828 695 801 718 832 903 738 907 M18162 GO_SEROTONIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_ACTIVITY.html Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. 2/14 Gene Ontology MF GO:0099589 0.999267803482914 0.999999414526698 680 786.3 833.5 0.551641615767271 598 0.133357412272391 -0.266310876825266 -1 3.47130310634757e-08 866 771 679 NA 863 848 680 864 875 598 819 908 M17980 GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. 2/15 Gene Ontology MF GO:0047555 0.999831019640267 0.999999414526698 895 779.5 839.5 0.619047619047619 535 0.152169218681146 -0.141863856765649 -1 5.92140211283897e-08 892 656 628 NA 856 823 745 901 866 535 893 909 M18925 GO_RETINOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_BINDING.html Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. 3/13 Gene Ontology MF GO:0019841 0.999286255530198 0.999999414526698 820 830.181818181818 842 0.515432507773122 661 0.251246430420809 0.180949417002313 1 1.88254780306261e-07 888 754 852 819 833 820 661 909 898 842 856 910 M18944 GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING.html Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 8/25 Gene Ontology MF GO:0090079 0.94814165601899 0.999999414526698 860 794.545454545455 847 0.256155999727364 512 0.135663533707814 -0.11236335595421 -1 3.771658410618e-08 703 856 860 774 918 903 637 512 890 847 840 911 M18433 GO_TELOMERASE_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_RNA_BINDING.html Interacting selectively and non-covalently with the telomerase RNA template. 7/16 Gene Ontology MF GO:0070034 0.980193349368437 0.999999414526698 690 795.363636363636 849 0.324413279916564 538 0.193881807456036 -0.122517699550553 -1 1.13541590791227e-07 687 899 740 859 772 902 538 907 909 687 849 912 M19004 GO_RIBONUCLEASE_P_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_P_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. 6/11 Gene Ontology MF GO:0004526 0.838494417110154 0.939603975324412 805 758.818181818182 850 0.166666666666667 462 0.214760407704572 -0.227935403808294 -1 0.0297621162293693 804 462 868 487 682 850 918 871 627 864 914 913 M19060 GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. 3/11 Gene Ontology MF GO:0008331 0.999416565027081 0.999999414526698 640 817.727272727273 853 0.525103197079344 639 0.106704823193457 0.106704823193457 1 0 639 911 883 872 796 750 853 708 919 878 786 914 M19154 GO_DNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with a DNA polymerase. 7/16 Gene Ontology MF GO:0070182 0.999345849971029 0.999999414526698 800 832.090909090909 854 0.519639004156172 663 0.231044508493627 -0.196163141848427 -1 1.61943267330043e-07 776 797 902 797 854 872 663 816 858 900 918 915 M19037 GO_ACID_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. 3/12 Gene Ontology MF GO:0003993 0.999977919744609 0.999999414526698 860 849.818181818182 857 0.657705115140104 748 0.141081531022122 -0.121816169262249 -1 4.47731259121714e-08 894 857 873 782 852 748 856 866 915 870 835 916 M18210 GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY.html Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 7/13 Gene Ontology MF GO:0009982 0.999999414526698 0.999999414526698 805 822 866 0.761904761904762 612 0.138694503090373 0.122780108675989 1 4.16641981266275e-08 805 777 688 798 866 917 887 891 904 612 897 917 M18691 GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. 7/13 Gene Ontology MF GO:0043142 0.999991928753351 0.999999414526698 890 847.454545454545 867 0.69047619047619 766 0.165823632428573 -0.113469772299558 -1 7.69978877225222e-08 806 877 799 842 896 890 774 867 888 766 917 918 M17930 GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. 2/12 Gene Ontology MF GO:0043855 0.999612325800068 0.999999414526698 910 803.3 868.5 0.582226617340384 522 0.315204270972753 -0.251220139838487 -1 2.71555149334472e-07 909 809 621 NA 883 868 908 739 905 522 869 919 M19181 GO_ODORANT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODORANT_BINDING.html Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell. 6/293 Gene Ontology MF GO:0005549 0.999947847740599 0.999999414526698 870 871.909090909091 870 0.626984126984127 829 0.218680042265446 -0.186772222100755 -1 1.45839462217864e-07 870 843 910 839 840 829 876 913 870 907 894 920 M19065 GO_TBP_CLASS_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TBP_CLASS_PROTEIN_BINDING.html Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). 9/25 Gene Ontology MF GO:0017025 0.982850533421989 0.999999414526698 915 818.545454545455 881 0.334075395241054 588 0.154079746807088 -0.134471717126526 -1 6.17023430691604e-08 842 915 886 896 888 616 880 588 914 881 698