Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M18138 GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT.html The action of a molecule that contributes to the structural integrity of the extracellular matrix. 34/94 Gene Ontology MF GO:0005201 5.34309429055196e-23 9.83129349461561e-21 5 24.1818181818182 5 4.85735844595633e-24 1 3.06483644308702 3.06483644308702 1 81.6169859457041 1 15 5 1 190 3 4 26 13 3 5 2 M18158 GO_EXTRACELLULAR_MATRIX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_BINDING.html Interacting selectively and non-covalently with a component of the extracellular matrix. 43/88 Gene Ontology MF GO:0050840 8.23538311938352e-19 6.8877749725753e-17 5 25.4545454545455 11 7.48671192671226e-20 2 2.533064099621 2.67908930765374 1 54.4906493901689 2 13 11 14 138 2 5 27 58 4 6 3 M18114 GO_COLLAGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_BINDING.html Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 43/105 Gene Ontology MF GO:0005518 7.52687370715158e-21 8.65590476322431e-19 15 34.3636363636364 12 6.84261246104686e-22 5 2.89232730735334 2.86695973089966 1 69.5364686889314 5 12 8 24 183 10 11 30 74 8 13 4 M18439 GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. 31/148 Gene Ontology MF GO:0004867 3.17076720612438e-19 2.91710582963443e-17 10 19.7272727272727 12 2.88251564193126e-20 7 2.84169467703908 2.84991815053265 1 62.5411255516201 12 17 10 25 11 7 9 31 56 10 29 5 M19114 GO_CELL_ADHESION_MOLECULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MOLECULE_BINDING.html Interacting selectively and non-covalently with a cell adhesion molecule. 97/272 Gene Ontology MF GO:0050839 4.51203132734069e-20 4.61229869017049e-18 15 36.3636363636364 13 4.10184666121879e-21 5 2.23831397545276 2.37607770571653 1 51.6481530481719 8 5 9 12 177 11 15 29 93 13 28 6 M19121 GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 14/31 Gene Ontology MF GO:0008191 1.25053472047823e-10 4.6019677713599e-09 5 18.4545454545455 15 1.13684974595392e-11 1 2.80205301909635 2.94200556213713 1 31.0936642836198 9 24 24 15 43 1 1 42 7 34 3 7 M18258 GO_GLYCOSAMINOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSAMINOGLYCAN_BINDING.html Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 95/306 Gene Ontology MF GO:0005539 5.62192787887944e-33 5.17217364856909e-30 5 26.5454545454545 17 5.11084352625406e-34 1 2.5653833223132 2.70886885571792 1 100 3 4 1 2 79 17 27 33 98 2 26 8 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 35/85 Gene Ontology MF GO:0019199 1.0253728986288e-08 1.65498783638333e-07 15 28.0909090909091 19 9.32157184916224e-10 6 2.22997008772434 2.20627689068563 1 20.1274487863448 14 19 34 6 24 9 12 44 81 48 18 9 M18852 GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with platelet-derived growth factor. 11/23 Gene Ontology MF GO:0048407 1.08715256549114e-11 4.76276362024691e-10 10 49.5454545454545 20 9.88320514087741e-13 7 3.35330899475749 3.35330899475749 1 41.6075419755502 7 50 20 17 278 16 10 63 9 26 49 10 M18873 GO_PEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 60/252 Gene Ontology MF GO:0030414 7.29064644707047e-17 4.79099623664631e-15 10 23.9090909090909 20 6.62786040642767e-18 6 2.45113615803271 2.55420110939186 1 46.7175824897095 25 11 13 46 28 6 21 20 75 9 9 11 M19199 GO_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 83/222 Gene Ontology MF GO:0019838 3.03853466173868e-12 1.39772594439979e-10 35 28.5454545454545 26 2.76230423794806e-13 7 2.24483043253829 2.46170274793707 1 29.4445137224429 16 7 19 26 35 27 31 14 85 33 21 12 M18092 GO_HEPARIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARIN_BINDING.html Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 76/236 Gene Ontology MF GO:0008201 1.21745568203172e-27 4.55199341695498e-25 45 37.2727272727273 29 1.10677789275611e-28 2 2.56957261431364 2.68164729166645 1 83.2523271144211 4 8 2 45 105 22 29 43 102 7 43 13 M18565 GO_INTEGRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_BINDING.html Interacting selectively and non-covalently with an integrin. 64/163 Gene Ontology MF GO:0005178 2.04986127734096e-13 1.10933669126687e-11 20 56.6363636363636 29 1.86351025212831e-14 6 2.28507367869902 2.4053931555719 1 33.319071774686 6 39 16 18 241 15 13 67 145 29 34 14 M17957 GO_SULFUR_COMPOUND_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BINDING.html Interacting selectively and non-covalently with a sulfur compound. 124/344 Gene Ontology MF GO:1901681 2.51139624429904e-21 3.30069220679303e-19 15 41.5454545454545 35 2.2830874948173e-22 7 2.42381239047652 2.67617879913802 1 59.6233774360695 15 35 7 13 57 38 69 24 135 19 45 15 M19034 GO_LAMININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMININ_BINDING.html Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. 20/43 Gene Ontology MF GO:0043236 1.41339282294675e-08 1.87474234565248e-07 25 51.0909090909091 38 1.2849025745701e-09 22 2.08240406345723 2.32263330716206 1 18.6454558635591 23 22 47 79 38 28 43 98 129 31 24 16 M18457 GO_GROWTH_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_ACTIVITY.html The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 57/168 Gene Ontology MF GO:0008083 1.27698096755858e-12 6.52679161196606e-11 20 65.1818181818182 41 1.16089178869029e-13 17 2.31858090913236 2.25897081910469 1 31.432498802486 18 41 17 59 157 20 47 158 141 40 19 17 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 26/67 Gene Ontology MF GO:0004714 1.75467934497659e-08 1.87474234565248e-07 15 40.4545454545455 44 1.59516305361053e-09 6 2.28449306872354 2.25324084329451 1 20.4549230721769 13 72 44 27 53 8 6 59 80 68 15 18 M18961 GO_CHEMOREPELLENT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOREPELLENT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. 19/41 Gene Ontology MF GO:0045499 3.92278077727846e-08 2.65364581992366e-07 15 75.7272727272727 44 3.56616440656807e-09 2 2.51816006691479 2.51816006691479 1 22.0413564209738 11 186 63 89 269 13 2 37 44 112 7 19 M18556 GO_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 24/72 Gene Ontology MF GO:0043394 7.74992890308004e-14 4.45620911927102e-12 45 71.9090909090909 45 7.04538991189119e-15 10 2.91274375890183 2.8724880300798 1 44.0068762701467 10 45 15 49 280 33 41 94 106 22 96 20 M17907 GO_PEPTIDASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_REGULATOR_ACTIVITY.html Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 84/301 Gene Ontology MF GO:0061134 3.87083689694985e-14 2.37411329679591e-12 65 45.4545454545455 47 3.51894263359082e-15 6 2.20492549453894 2.47384111308955 1 34.1154390067097 63 6 14 47 25 68 76 34 96 17 54 21 M18617 GO_ENZYME_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_INHIBITOR_ACTIVITY.html Binds to and stops, prevents or reduces the activity of an enzyme. 147/494 Gene Ontology MF GO:0004857 2.72803506316569e-11 1.14081466277838e-09 35 53.8181818181818 48 2.48003187563592e-12 13 2.0435725761388 2.2161806442899 1 24.3245974737585 65 34 21 48 13 97 78 57 122 32 25 22 M18984 GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON.html The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 53/144 Gene Ontology MF GO:0005200 3.83024606107368e-08 2.62055267355268e-07 40 69.4545454545455 53 3.48204193432643e-09 16 2.41762992813261 2.86865721777094 1 21.1789577721778 38 42 32 16 187 112 60 112 53 38 74 23 M18089 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 3/11 Gene Ontology MF GO:0016813 4.76915965724045e-07 1.49748357838267e-06 40 133 56 4.76916068076053e-08 18 3.40239981309316 -3.40239981309316 -1 26.3777102123925 40 62 663 104 291 30 40 49 18 110 56 24 M18305 GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 4/20 Gene Ontology MF GO:0005328 9.78766437020613e-09 1.62065932828291e-07 60 113.727272727273 57 9.78766441331539e-10 6 2.34357010932215 2.34357010932215 1 21.1811847873948 57 82 709 23 85 43 8 6 16 163 59 25 M18839 GO_GLYCOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_BINDING.html Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 64/193 Gene Ontology MF GO:0001948 2.644924146057e-12 1.2807001128276e-10 30 54.3636363636364 58 2.40447649641835e-13 3 2.3528220988365 2.68358626049963 1 30.9799186032501 28 10 18 3 75 85 111 58 115 30 65 26 M17875 GO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_BINDING.html Interacting selectively and non-covalently with a SMAD signaling protein. 49/113 Gene Ontology MF GO:0046332 3.42508097258895e-08 2.45095609862706e-07 40 57.0909090909091 59 3.11371002355682e-09 20 2.53401624208575 2.6737306278433 1 22.2965319910084 32 92 40 20 98 65 44 71 40 59 67 27 M17981 GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 37/157 Gene Ontology MF GO:0022843 1.05776876046592e-07 4.99049876732637e-07 55 94.8181818181818 61 9.61608010294421e-09 27 1.88776623860601 2.08678242507642 1 15.8343227524508 43 212 52 33 166 121 61 55 159 27 114 28 M18468 GO_FIBRONECTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRONECTIN_BINDING.html Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. 22/46 Gene Ontology MF GO:0001968 1.56308627242269e-08 1.87474234565248e-07 25 74.9090909090909 61 1.4209875304803e-09 2 2.22468237377667 2.19838696310253 1 19.9193892805767 24 99 53 63 182 21 18 92 209 61 2 29 M18333 GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. 15/39 Gene Ontology MF GO:0005520 1.94006617482866e-08 1.92673567638342e-07 50 67.0909090909091 64 1.76369653812463e-09 4 2.66104877727324 2.69458388563024 1 23.7844528974448 47 77 64 4 60 96 108 69 38 143 32 30 M19086 GO_EPHRIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_ACTIVITY.html Combining with an ephrin to initiate a change in cell activity. 11/20 Gene Ontology MF GO:0005003 2.20451224560322e-07 8.51496019772218e-07 40 137.181818181818 66 2.00410224227875e-08 20 2.66346686673378 2.66346686673378 1 21.5181896893003 36 514 134 189 216 40 20 66 35 206 53 31 M19157 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 13/56 Gene Ontology MF GO:0005245 2.89481051797559e-08 2.21935473044795e-07 80 67.7272727272727 73 2.63164596006015e-09 10 2.16690599594155 2.47694934154548 1 19.190702602231 73 78 96 10 154 115 52 15 17 78 57 32 M19106 GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). 15/59 Gene Ontology MF GO:0015370 1.65656959031325e-08 1.87474234565248e-07 40 93.3636363636364 74 1.50597236616999e-09 9 2.00668769151945 2.16069731220306 1 17.9675056109148 37 143 111 95 74 64 37 9 90 325 42 33 M17890 GO_PROTEIN_KINASE_C_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_BINDING.html Interacting selectively and non-covalently with protein kinase C. 41/75 Gene Ontology MF GO:0005080 1.70210306759338e-08 1.87474234565248e-07 75 121 76 1.5473664370566e-09 23 1.82782419012879 2.00859357078712 1 16.3659952261293 74 281 127 86 51 76 57 23 289 232 35 34 M18672 GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). 12/36 Gene Ontology MF GO:0005343 8.82056990438451e-10 2.79824976277026e-08 75 101.818181818182 76 8.01869991629182e-11 1 2.32951731807703 2.58866841674811 1 23.4193461640642 71 244 105 76 123 113 45 1 66 246 30 35 M17988 GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). 5/19 Gene Ontology MF GO:0005283 3.56020892431428e-09 9.35826345819752e-08 75 157.090909090909 77 3.56020893001806e-10 3 2.34357010932215 2.34357010932215 1 21.9251330439235 77 313 630 69 145 104 74 3 22 216 75 36 M19229 GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY.html Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. 7/21 Gene Ontology MF GO:0030296 8.27920249847965e-07 2.39524097440292e-06 45 204.363636363636 79 8.27920558301499e-08 20 2.53770853094303 2.53770853094303 1 18.9850238969254 45 372 920 179 322 62 32 79 36 181 20 37 M18486 GO_SCAFFOLD_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAFFOLD_PROTEIN_BINDING.html Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. 34/84 Gene Ontology MF GO:0097110 1.18182804374737e-08 1.74030840154737e-07 175 90.4545454545455 80 1.07438913645099e-09 7 2.14530359922861 2.5407159178121 1 19.3009208586057 75 94 51 19 175 175 144 7 41 80 134 38 M18989 GO_ALPHA_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_ACTININ_BINDING.html Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. 12/31 Gene Ontology MF GO:0051393 1.50024678097012e-08 1.87474234565248e-07 140 87.7272727272727 82 1.36386071927342e-09 19 1.80014351261628 1.96907058256426 1 16.1181476096536 49 126 136 77 42 119 112 19 137 66 82 39 M18166 GO_NITRIC_OXIDE_SYNTHASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_SYNTHASE_BINDING.html Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. 15/45 Gene Ontology MF GO:0050998 2.5834909377545e-07 9.40916799652439e-07 85 126.363636363636 83 2.34862840103411e-08 29 4.10320085118889 4.25772810930809 1 32.9129691251182 46 405 84 40 226 53 54 136 29 234 83 40 M18349 GO_SIGNALING_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_RECEPTOR_ACTIVITY.html Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 304/2031 Gene Ontology MF GO:0038023 1.15224478951892e-21 1.76677534392901e-19 320 112.727272727273 84 1.04749526319902e-22 6 1.93835375980214 1.97706008803778 1 48.3818440099576 19 113 6 318 23 84 84 154 318 12 109 41 M18747 GO_BETA_AMYLOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_BINDING.html Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. 14/39 Gene Ontology MF GO:0001540 1.4778159707539e-08 1.87474234565248e-07 85 126.818181818182 84 1.34346907334627e-09 23 1.88422457913936 2.04498663514507 1 16.8709937753251 124 26 161 82 41 334 388 47 23 84 85 42 M18900 GO_PROTEIN_TYROSINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_BINDING.html Interacting selectively and non-covalently with protein tyrosine kinase. 39/84 Gene Ontology MF GO:1990782 4.50842982734183e-07 1.45535278636999e-06 70 93.8181818181818 84 4.09857341022584e-08 37 1.9385436118126 2.06182066191869 1 15.0608827402194 55 93 103 117 263 58 67 84 70 85 37 43 M17888 GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 46/210 Gene Ontology MF GO:0005244 4.48153024738529e-07 1.45176331957552e-06 85 121.272727272727 86 4.07411923663617e-08 36 1.7995863284582 2.01801772136666 1 13.9838681773822 81 199 65 55 262 160 82 86 195 36 113 44 M17901 GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING.html Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. 15/23 Gene Ontology MF GO:0001965 2.1344444450847e-08 1.976913127664e-07 105 67.0909090909091 87 1.94040405981193e-09 3 2.34568968412421 2.34568968412421 1 20.930913141493 22 101 101 164 133 14 3 13 87 92 8 45 M18236 GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 6/14 Gene Ontology MF GO:0004185 3.02052262035962e-07 1.05660867328169e-06 45 187.727272727273 87 3.02052303091976e-08 7 3.09769842217701 3.09769842217701 1 24.6398904246046 41 221 694 176 398 35 7 78 60 268 87 46 M19115 GO_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 707/2125 Gene Ontology MF GO:0005102 9.44407305169079e-19 7.24045600629627e-17 45 151.272727272727 88 9.44407305169081e-20 1 1.90283159750496 2.13853742646927 1 40.8783166254455 44 1 896 44 36 99 137 119 199 1 88 47 M19010 GO_FRIZZLED_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRIZZLED_BINDING.html Interacting selectively and non-covalently with the frizzled (fz) receptor. 17/44 Gene Ontology MF GO:0005109 5.20375598215126e-08 3.1496417786705e-07 115 94 90 4.73068736839815e-09 5 2.91390698945833 2.83992705092812 1 25.2166864170826 113 123 59 5 120 168 90 184 37 65 70 48 M17972 GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 56/188 Gene Ontology MF GO:0072509 1.2489288969022e-08 1.7710016693944e-07 60 106.636363636364 91 1.13538991272028e-09 33 1.67387722321948 1.78896334960461 1 15.0426637211733 58 91 73 81 33 132 175 140 224 60 106 49 M18080 GO_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. 14/27 Gene Ontology MF GO:0016289 2.19460549837571e-08 1.97762447895865e-07 30 147.363636363636 91 1.99509592751632e-09 26 1.6446012194751 -1.27500361418881 -1 14.6746615358573 91 124 192 157 67 26 88 481 30 301 64 50 M18174 GO_THIOLESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOLESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. 24/40 Gene Ontology MF GO:0016790 2.36793509315376e-08 1.99990549834811e-07 50 131.636363636364 91 2.15266828967332e-09 4 1.43563744379111 -1.1831129992725 -1 12.8007947051852 50 122 246 237 78 4 51 278 91 274 17 51 M18075 GO_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_BINDING.html Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. 367/914 Gene Ontology MF GO:0019900 2.25088075505195e-08 1.97762447895865e-07 85 108.727272727273 92 2.04625525280121e-09 60 1.64402773205667 1.96298148355053 1 14.6695443473614 79 84 92 149 70 82 115 128 239 98 60 52 M18315 GO_POLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 10/23 Gene Ontology MF GO:0030247 1.46670575053747e-07 6.24708004858551e-07 30 126.090909090909 95 1.3333689530186e-08 14 2.10745454208787 2.10745454208787 1 17.4034525182575 29 245 95 286 305 31 14 28 227 104 23 53 M18079 GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of metal ions from one side of a membrane to the other. 130/461 Gene Ontology MF GO:0046873 3.74259336033207e-10 1.22970924696625e-08 30 113.454545454545 97 3.40235760088068e-11 18 1.78865084041943 1.89648431941314 1 18.8319679446522 52 87 27 28 97 148 154 256 241 18 140 54 M18063 GO_ANION_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). 19/65 Gene Ontology MF GO:0015296 6.4834459075257e-08 3.57171870354709e-07 70 113.090909090909 99 5.89404190781292e-09 53 1.94877538702833 2.19653729986351 1 16.7228589443759 70 202 110 94 136 111 53 64 99 236 69 55 M18099 GO_WNT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_PROTEIN_BINDING.html Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. 18/33 Gene Ontology MF GO:0017147 4.54567998808437e-07 1.46224670945371e-06 50 134.636363636364 99 4.13243720665573e-08 26 2.05304291908297 2.2095072484793 1 15.9448394870535 26 331 154 99 413 49 48 45 148 137 31 56 M18366 GO_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTININ_BINDING.html Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. 18/47 Gene Ontology MF GO:0042805 3.06056060531054e-08 2.2707385136175e-07 100 109.545454545455 100 2.78232786171633e-09 16 1.79846812617691 1.92757076887717 1 15.9039222703326 66 100 126 97 191 122 176 16 173 54 84 57 M19124 GO_EPHRIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ephrin receptor. 21/43 Gene Ontology MF GO:0046875 5.47477009634117e-08 3.24116621198643e-07 80 139.181818181818 100 4.97706384780233e-09 12 2.14319684434986 2.14319684434986 1 18.5115434386006 33 496 176 191 125 79 77 41 100 201 12 58 M18982 GO_HISTONE_ACETYLTRANSFERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_ACETYLTRANSFERASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone acetyltransferase. 18/38 Gene Ontology MF GO:0035035 1.33831205401027e-07 5.78050276849505e-07 75 106.636363636364 101 1.21664739583906e-08 25 1.8166144071707 2.17309208374758 1 15.0831939921932 72 25 138 153 185 87 35 110 101 212 55 59 M18211 GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY.html Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 117/1410 Gene Ontology MF GO:0004930 5.93635140098038e-08 3.35753893513821e-07 65 224.636363636364 103 5.3966832374213e-09 17 1.96648352017636 2.10421006857175 1 16.9451101237658 17 688 39 755 129 67 64 103 442 106 61 60 M18251 GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a monosaccharide from one side of a membrane to the other. 7/25 Gene Ontology MF GO:0015145 4.55350470764952e-06 9.92707187449659e-06 105 179.272727272727 103 4.55351403815873e-07 24 1.7788210563729 1.7788210563729 1 11.8457094763915 30 58 698 101 436 44 24 125 176 177 103 61 M18545 GO_INTERMEDIATE_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BINDING.html Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. 18/27 Gene Ontology MF GO:0019215 1.80710106553593e-08 1.87474234565248e-07 120 100.454545454545 103 1.64281916398148e-09 23 2.46474345912675 2.93376067271222 1 22.0688514021491 173 23 42 61 56 191 103 118 123 95 120 62 M18222 GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS.html The action of a molecule that contributes to the structural integrity of the lens of an eye. 5/22 Gene Ontology MF GO:0005212 8.52809093247244e-08 4.33472025296942e-07 105 176.909090909091 104 8.52809125974997e-09 22 1.64178392925925 1.85299996906246 1 13.9047561020926 96 207 692 248 197 71 68 22 139 102 104 63 M18390 GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. 12/19 Gene Ontology MF GO:0071617 1.067258086231e-06 2.87940598044728e-06 80 153.636363636364 104 9.70235094524298e-08 25 1.70451485894834 -1.53404254469124 -1 12.5703679836309 141 104 227 220 316 47 25 93 76 361 80 64 M18157 GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY.html Combining with a neuropeptide to initiate a change in cell activity. 3/49 Gene Ontology MF GO:0008188 7.20745113372771e-07 2.12745125499144e-06 95 189.909090909091 105 7.2074534713596e-08 33 2.20709701850502 2.20709701850502 1 16.6629233406293 92 264 678 151 292 94 56 105 33 276 48 65 M18958 GO_MYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_BINDING.html Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. 48/108 Gene Ontology MF GO:0017022 1.94767845547454e-08 1.92673567638342e-07 505 315.545454545455 105 1.77061679337955e-09 8 2.22790675723324 -1.85668478141689 -1 19.9130295040382 504 71 55 8 61 787 440 604 105 96 740 66 M17886 GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 8/19 Gene Ontology MF GO:0070008 1.40332996630073e-06 3.64707222880416e-06 110 192.636363636364 106 1.40333085250226e-07 30 2.79446636791019 3.09769842217701 1 20.2267143135993 134 233 614 106 457 106 30 68 57 224 90 67 M18129 GO_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. 12/41 Gene Ontology MF GO:0004180 4.67982812753021e-08 2.97592386690275e-07 70 188 108 4.25438929734479e-09 18 2.35032328839359 2.77066047715311 1 20.4165636575899 68 310 215 387 434 63 34 18 108 359 72 68 M18948 GO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger to initiate a change in cell activity. 399/2329 Gene Ontology MF GO:0004872 1.48434567944184e-27 4.55199341695498e-25 5 144.363636363636 110 1.34940516312894e-28 3 1.91368911743112 1.95438726756609 1 62.0021674943949 27 151 3 345 68 110 106 249 378 5 146 69 M18165 GO_CALCIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_BINDING.html Interacting selectively and non-covalently with calcium ions (Ca2+). 266/853 Gene Ontology MF GO:0005509 1.84327661139037e-25 4.23953620619785e-23 115 105.545454545455 111 1.67570601035487e-26 4 2.03749934343334 2.21001099125169 1 60.6734016401483 61 114 4 98 32 146 131 193 265 6 111 70 M18544 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. 43/147 Gene Ontology MF GO:0015085 2.09076070595002e-08 1.97084047342755e-07 60 100.545454545455 112 1.9006915689268e-09 37 1.7721946652348 1.89852214105789 1 15.8166892074637 60 120 60 37 64 152 169 124 163 45 112 71 M19019 GO_NEUROTROPHIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neurotrophin receptor. 14/21 Gene Ontology MF GO:0005165 2.14881861702609e-08 1.976913127664e-07 205 153.363636363636 114 1.95347148910396e-09 27 1.9336763082749 2.44731559169654 1 17.2544606549917 204 27 108 65 66 394 283 114 77 199 150 72 M18361 GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. 4/19 Gene Ontology MF GO:0015114 1.74706610622656e-08 1.87474234565248e-07 120 229.090909090909 116 1.74706611996164e-09 10 1.70104608789579 1.70104608789579 1 15.2308477773153 116 408 722 169 171 105 86 10 94 561 78 73 M18397 GO_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). 544/1327 Gene Ontology MF GO:0032403 3.03738516795616e-08 2.2707385136175e-07 85 200.727272727273 116 3.03738520947185e-09 35 1.82891439270994 2.13855571293728 1 16.1731597872117 85 224 731 103 96 307 145 90 276 35 116 74 M18010 GO_RETINOIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_BINDING.html Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. 4/31 Gene Ontology MF GO:0001972 2.95853564935074e-09 8.24803878000813e-08 5 187.272727272727 118 2.95853565328956e-10 1 4.39353459956901 4.39353459956901 1 41.4241802584275 109 149 636 7 416 289 118 2 2 331 1 75 M18012 GO_STEROID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BINDING.html Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. 39/140 Gene Ontology MF GO:0005496 8.15000801940835e-09 1.54018898320046e-07 895 359.727272727273 118 7.40909822690948e-10 9 2.07800538636698 -2.09902919864217 -1 18.8421853191854 893 16 62 9 15 672 713 592 118 114 753 76 M18015 GO_I_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_SMAD_BINDING.html Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. 10/18 Gene Ontology MF GO:0070411 2.2153722868675e-07 8.51496019772218e-07 220 143.272727272727 118 2.01397500904794e-08 10 1.94479230927887 1.94479230927887 1 15.7120065909411 118 107 262 34 218 217 75 88 10 294 153 77 M18838 GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY.html Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. 11/31 Gene Ontology MF GO:0030159 1.11299439435811e-06 2.98529108690806e-06 225 134.545454545455 122 1.01181359766333e-07 39 1.73423761584438 2.07308977741467 1 12.7533630481248 147 79 224 223 320 137 39 100 50 122 39 78 M18290 GO_SH3_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. 61/157 Gene Ontology MF GO:0017124 5.45452651195474e-08 3.24116621198643e-07 60 106.636363636364 124 4.95866058835496e-09 16 1.56837337541227 1.73736657663731 1 13.5465910476596 59 159 211 125 124 34 58 48 152 187 16 79 M18656 GO_ION_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. 16/51 Gene Ontology MF GO:0022839 5.95962526095317e-09 1.27508261397137e-07 555 284 127 5.41784116099755e-10 8 2.02207606376138 2.0741055166262 1 18.5558415194123 555 48 88 31 8 788 422 713 127 113 231 80 M18700 GO_CORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 21/48 Gene Ontology MF GO:0015026 3.32037434219997e-07 1.14840014843007e-06 25 127.181818181818 131 3.01852258484659e-08 20 1.76874473448243 1.7992483752073 1 13.9838766125365 20 271 143 168 290 25 22 40 238 131 51 81 M19008 GO_PEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 21/145 Gene Ontology MF GO:0001653 1.7448133584845e-05 3.33034914897456e-05 75 159.818181818182 132 1.58620654245475e-06 21 2.20848816176621 2.06084358897388 1 13.1617748070155 21 294 61 193 450 74 36 207 216 74 132 82 M18391 GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE.html The action of a molecule that contributes to the structural integrity of a muscle fiber. 27/67 Gene Ontology MF GO:0008307 2.78302454768235e-08 2.15926568991322e-07 80 145.454545454545 134 2.53002234807993e-09 38 2.50785540352372 2.85876717499617 1 22.2500334913659 76 182 38 62 86 305 289 162 134 58 208 83 M19073 GO_RECEPTOR_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_REGULATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. 24/55 Gene Ontology MF GO:0030545 1.59569648378242e-08 1.87474234565248e-07 210 217.727272727273 134 1.45063317759662e-09 46 2.06807812884765 1.80167119666183 1 18.5171841207462 206 242 100 57 46 321 134 743 120 91 335 84 M19111 GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY.html Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 5/27 Gene Ontology MF GO:0005326 2.27856733445236e-08 1.97762447895865e-07 100 192.909090909091 137 2.27856735781577e-09 26 2.34357010932215 2.34357010932215 1 20.9115125063189 97 223 894 96 80 140 26 39 168 222 137 85 M18745 GO_ACTIVIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_BINDING.html Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits. 5/16 Gene Ontology MF GO:0048185 4.76976382234686e-05 8.40648029992167e-05 140 237.363636363636 138 4.76986620335079e-06 62 2.11782197334231 2.11782197334231 1 11.4879084366008 62 111 806 217 542 204 92 138 138 103 198 86 M17870 GO_SIGNAL_TRANSDUCER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCER_ACTIVITY.html Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 472/2441 Gene Ontology MF GO:0004871 4.91004152220328e-17 3.47479861571309e-15 15 136.090909090909 140 4.46367411109387e-18 11 1.77762460193992 1.87040236338939 1 34.2108008258614 39 63 12 303 17 172 140 237 315 11 188 87 M17908 GO_CYTOSKELETAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). 431/1066 Gene Ontology MF GO:0008092 8.69531836303225e-11 3.3332053724957e-09 240 142.090909090909 145 7.90483487579627e-12 23 1.82601066089617 2.12310204632879 1 20.6032325972552 145 239 23 120 40 273 186 156 236 24 121 88 M18686 GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY.html Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. 15/25 Gene Ontology MF GO:0042813 2.76899247871135e-06 6.49865581738378e-06 55 189.818181818182 145 2.51726905805695e-07 44 1.71977135511251 1.8509775081411 1 11.8736576396841 53 350 205 288 364 88 55 82 414 145 44 89 M18977 GO_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 35/126 Gene Ontology MF GO:0005267 3.40540642051534e-07 1.17339846699405e-06 100 175.181818181818 147 3.09582449785673e-08 67 1.75351807347889 1.89172514014111 1 13.8416652417175 100 305 68 143 243 212 98 187 357 67 147 90 M18914 GO_CXCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CXCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. 6/15 Gene Ontology MF GO:0045236 7.12868018047616e-08 3.73107484368215e-07 40 226.909090909091 148 7.12868040915753e-09 36 1.98305592325427 1.98305592325427 1 16.9669917905871 107 236 848 256 148 36 38 121 397 271 38 91 M17969 GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. 13/29 Gene Ontology MF GO:0016411 1.44603502141583e-06 3.71606765280046e-06 65 169 150 1.31457815625373e-07 28 1.70451485894834 -1.53404254469124 -1 12.3190359956145 150 171 248 254 367 37 28 65 89 388 62 92 M18782 GO_NADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_BINDING.html Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. 25/65 Gene Ontology MF GO:0050661 9.57355006973975e-08 4.70998185249229e-07 150 168.909090909091 154 8.70322771485792e-09 66 1.94955654271459 -1.95324225275686 -1 16.4178071758494 149 403 165 74 158 66 210 148 242 154 89 93 M18680 GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. 59/148 Gene Ontology MF GO:0008194 6.58747442897875e-09 1.37738101696828e-07 145 176.636363636364 155 5.98861313518514e-10 9 1.8162363563472 2.13870307094938 1 16.5859045371004 127 252 141 145 9 456 243 17 155 202 196 94 M18889 GO_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BINDING.html Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 146/308 Gene Ontology MF GO:0048037 1.81360944307685e-08 1.87474234565248e-07 155 180.363636363636 156 1.64873587093424e-09 19 1.43622054205779 -1.29167029837525 -1 12.8596493018381 155 155 218 156 58 19 309 314 409 158 33 95 M19185 GO_CYTOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a cytokine receptor. 134/377 Gene Ontology MF GO:0005126 9.54209075980264e-08 4.70998185249229e-07 160 184.272727272727 156 8.67462833970282e-09 50 1.70228428003091 1.98603710780692 1 14.3354522745986 156 156 71 296 156 338 265 132 314 93 50 96 M18646 GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a carboxylic ester bond. 52/170 Gene Ontology MF GO:0052689 1.16820269809232e-08 1.74030840154737e-07 70 173.818181818182 157 1.06200245845045e-09 29 1.54662256030603 -1.33234234272751 -1 13.9146920441415 245 70 203 416 29 50 313 157 262 99 68 97 M18752 GO_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any chemokine receptor. 22/77 Gene Ontology MF GO:0042379 5.94868311334269e-08 3.35753893513821e-07 145 220.454545454545 159 5.40789388562904e-09 117 1.69965586135232 1.99114450429828 1 14.6458666605196 144 283 117 386 130 248 146 131 476 159 205 98 M18014 GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. 8/15 Gene Ontology MF GO:0010314 1.79783935108645e-08 1.87474234565248e-07 160 262.181818181818 160 1.79783936563146e-09 11 2.93445784772599 2.93445784772599 1 26.2745863082429 135 765 639 160 286 241 159 11 83 347 58 99 M18800 GO_SOLUTE_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). 42/113 Gene Ontology MF GO:0015294 3.43666670350968e-08 2.45095609862706e-07 290 238.454545454545 160 3.12424250654054e-09 44 1.63981260824598 2.01593180745606 1 14.4285315188945 286 44 129 116 99 595 363 343 160 135 353 100 M18418 GO_BINDING_BRIDGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_BRIDGING.html The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. 86/250 Gene Ontology MF GO:0060090 2.62134161419801e-08 2.15926568991322e-07 130 176.545454545455 161 2.38303785948345e-09 81 1.77161926423359 2.07000890778225 1 15.7180461977387 183 197 125 128 81 350 214 127 158 161 218 101 M18151 GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. 131/498 Gene Ontology MF GO:0022803 1.43125508088338e-10 5.06444105543351e-09 160 216.454545454545 163 1.30114098270590e-11 14 1.82757214036974 1.91194568224223 1 20.1789355512324 159 66 25 72 163 366 245 694 340 14 237 102 M18602 GO_DRUG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_BINDING.html Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 65/211 Gene Ontology MF GO:0008144 7.13770839660933e-08 3.73107484368215e-07 175 208.181818181818 163 6.48882602562368e-09 81 2.05319113508587 2.11536345038855 1 17.5670674781242 171 158 81 112 146 367 171 452 328 141 163 103 M18232 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 44/118 Gene Ontology MF GO:0003705 5.73505227725905e-06 1.2185330473622e-05 60 217.363636363636 165 5.21369747971676e-07 56 1.63427732869895 1.75351799701553 1 10.6895167045881 56 349 191 438 401 83 107 129 321 165 151 104 M18284 GO_STEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BINDING.html Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. 18/56 Gene Ontology MF GO:0032934 1.35224186415379e-08 1.87474234565248e-07 650 280.727272727273 166 1.22931079315038e-09 34 1.62792424362401 -1.50880082752743 -1 14.5761284408077 650 74 166 102 34 341 655 395 132 139 400 105 M18123 GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. 20/60 Gene Ontology MF GO:0015179 2.7229110614019e-08 2.15926568991322e-07 535 274 167 2.47537372282092e-09 83 2.13473092492867 2.95000026876404 1 18.9396223025399 531 167 109 127 83 838 436 248 86 120 269 106 M18452 GO_CYCLIC_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 9/43 Gene Ontology MF GO:0030551 2.00429030452652e-06 4.87000642184295e-06 85 279.363636363636 167 2.00429211225965e-07 74 1.72455338819418 1.72455338819418 1 12.1942743708028 82 371 743 365 474 155 128 74 167 392 122 107 M19036 GO_CYTOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_ACTIVITY.html Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 27/95 Gene Ontology MF GO:0004896 1.07040384757902e-07 5.02434459067704e-07 105 226.545454545455 167 9.73094454235656e-09 70 1.55303601277851 1.30119251789559 1 13.0205836514446 104 140 151 306 167 203 70 646 252 124 329 108 M18288 GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING.html Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. 23/59 Gene Ontology MF GO:0050431 2.00085514141479e-07 7.90037223219575e-07 170 172.818181818182 168 1.81895938489864e-08 52 1.80675488813266 1.92840049820952 1 14.675040977912 166 164 168 329 213 188 136 52 219 171 95 109 M17882 GO_CYTOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_BINDING.html Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 59/153 Gene Ontology MF GO:0019955 1.75976936818341e-06 4.39942342045852e-06 35 198.090909090909 169 1.59979161437818e-07 34 1.57667350742203 1.63290857122558 1 11.2412373406448 34 316 169 347 374 55 46 72 425 255 86 110 M18060 GO_ACTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. 188/479 Gene Ontology MF GO:0003779 1.36187166594989e-09 4.17640644224634e-08 310 236.636363636364 169 1.23806515162994e-10 21 1.85453727642875 -1.55533097315 -1 18.2149293118686 308 65 28 114 103 666 329 345 169 21 455 111 M18088 GO_ACTIN_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BINDING.html Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. 70/170 Gene Ontology MF GO:0051015 1.08798698512146e-07 5.02988957945601e-07 440 287.181818181818 170 9.8907912629702e-09 62 1.78000009811734 -1.47132925563885 -1 14.9223055159478 439 137 79 83 170 704 351 400 164 62 570 112 M18711 GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. 29/83 Gene Ontology MF GO:0035004 1.05501771666107e-07 4.99049876732637e-07 160 182.818181818182 170 9.59107061140746e-09 96 2.14124334791303 2.06831750510378 1 17.9604539321037 158 96 131 170 165 231 194 259 179 117 311 113 M18331 GO_MACROLIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROLIDE_BINDING.html Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. 9/18 Gene Ontology MF GO:0005527 1.7122326594205e-07 6.9899320908768e-07 150 272.363636363636 171 1.71223279134884e-08 28 1.51633531362558 1.6676763199086 1 12.4234805330779 335 28 716 51 208 648 498 149 45 147 171 114 M18712 GO_FK506_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FK506_BINDING.html Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. 9/18 Gene Ontology MF GO:0005528 1.7122326594205e-07 6.9899320908768e-07 340 280 172 1.71223279134884e-08 29 1.51633531362558 1.6676763199086 1 12.4234805330779 336 29 801 52 209 649 499 137 46 150 172 115 M18553 GO_ION_CHANNEL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_CHANNEL_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. 68/168 Gene Ontology MF GO:0044325 1.14119406152517e-07 5.17191397341457e-07 140 242.090909090909 173 1.03744920065611e-08 68 1.35019147923889 1.43365652439143 1 11.2973508805537 139 68 124 285 173 240 148 521 601 116 248 116 M19095 GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a G-protein coupled receptor. 113/333 Gene Ontology MF GO:0001664 1.44230859914918e-09 4.28039971360401e-08 175 203.909090909091 173 1.31118963644977e-10 29 2.25204736004327 2.40203005409182 1 22.0871835372081 172 279 29 173 49 373 125 356 271 71 345 117 M18678 GO_CHEMOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_ACTIVITY.html The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 15/62 Gene Ontology MF GO:0008009 4.67286214165131e-07 1.47733098636399e-06 180 195.181818181818 176 4.24805739470975e-08 85 1.98309494416536 2.26184785146757 1 15.3898277460206 110 188 85 328 268 176 93 147 429 144 179 118 M19220 GO_COENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BINDING.html Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 101/214 Gene Ontology MF GO:0050662 2.08581968450081e-08 1.97084047342755e-07 180 181 176 1.89619973116042e-09 24 1.4149323930836 -1.29797964069559 -1 12.6281530614088 132 178 343 150 63 24 226 176 389 263 47 119 M18314 GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY.html Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. 7/11 Gene Ontology MF GO:0005092 8.3705923000025e-09 1.54018898320046e-07 330 255.181818181818 178 8.37059233153257e-10 19 1.64751675423851 1.89026312105093 1 14.9387560267389 326 30 713 165 19 515 349 83 72 178 357 120 M18823 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. 9/20 Gene Ontology MF GO:0016641 4.80544590177582e-08 2.98716907407686e-07 255 262.363636363636 178 4.8054460056912e-09 60 2.66497114475843 3.40846003882909 1 23.1440066029955 253 106 825 60 121 403 375 178 154 87 324 121 M19194 GO_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. 80/319 Gene Ontology MF GO:0005261 5.89710089164497e-08 3.35753893513821e-07 180 139.545454545455 179 5.36100095428797e-09 16 1.83801626722495 1.93381469257991 1 15.8381128473534 64 179 33 29 211 184 163 265 211 16 180 122 M18192 GO_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASE_BINDING.html Interacting selectively and non-covalently with any protease or peptidase. 60/192 Gene Ontology MF GO:0002020 2.22903355357963e-07 8.51496019772218e-07 290 218.909090909091 180 2.02639434493154e-08 115 1.66350700687333 2.13404110200757 1 13.4394981909949 290 180 148 115 219 629 257 143 117 126 184 123 M18707 GO_CHEMOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_BINDING.html Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 12/31 Gene Ontology MF GO:0019956 1.01185530577865e-06 2.79551616010918e-06 310 217.636363636364 180 9.19868882878036e-08 16 2.06763627444618 2.06763627444618 1 15.2836361009768 42 531 180 308 604 29 16 107 308 247 22 124 M18980 GO_APOLIPOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOLIPOPROTEIN_BINDING.html Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex. 7/26 Gene Ontology MF GO:0034185 1.34979748007394e-06 3.52787977746599e-06 125 306.454545454545 180 1.3497982999536e-07 27 2.06679419090693 2.06679419090693 1 14.9994248728389 123 480 865 154 560 180 49 160 461 312 27 125 M17964 GO_CARBOHYDRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BINDING.html Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. 102/328 Gene Ontology MF GO:0030246 1.46836986885207e-08 1.87474234565248e-07 80 157.090909090909 181 1.33488170786598e-09 39 1.72078292544141 1.86981982675748 1 15.4075677344132 78 67 54 295 39 306 203 181 268 47 190 126 M18336 GO_TROPOMYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPOMYOSIN_BINDING.html Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. 6/14 Gene Ontology MF GO:0005523 4.31511707024571e-08 2.83564836044718e-07 90 222.636363636364 181 4.31511715403677e-09 87 2.71294922696209 2.92179260377935 1 23.6423083117049 87 195 717 249 114 181 91 305 217 134 159 127 M18180 GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY.html Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. 10/21 Gene Ontology MF GO:0004029 1.24937763668766e-07 5.50657978498022e-07 550 316.363636363636 182 1.13579791603608e-08 80 1.72088201246105 -1.57493797313819 -1 14.3366286142361 550 80 152 158 179 344 570 578 150 182 537 128 M17982 GO_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 83/232 Gene Ontology MF GO:0004713 7.48217217996110e-09 1.49643443599222e-07 250 191.363636363636 183 6.80197473218898e-10 12 1.7979389462123 2.06908291809823 1 16.3326526258101 125 267 104 178 12 313 177 246 250 250 183 129 M18549 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING.html Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. 8/27 Gene Ontology MF GO:0016922 4.1665334873235e-06 9.23665255021113e-06 135 268.636363636364 183 4.1665412993447e-07 45 1.31900091029961 -1.31900091029961 -1 8.83858930559141 131 263 767 183 543 45 71 219 162 519 52 130 M18654 GO_GLUCURONOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. 7/36 Gene Ontology MF GO:0015020 1.73228751817382e-07 6.9899320908768e-07 105 218.272727272727 185 1.73228765321073e-08 1 2.24372285406484 2.5555540239471 1 18.3830369255619 105 205 792 53 249 285 185 32 1 480 14 131 M18337 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. 28/79 Gene Ontology MF GO:0015171 8.29937452057273e-08 4.26560031224967e-07 150 225.454545454545 186 7.54488621241991e-09 101 1.9291501225426 2.31552132765079 1 16.3564711029645 304 201 120 194 150 618 324 186 149 101 133 132 M18554 GO_FILAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMIN_BINDING.html Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. 9/17 Gene Ontology MF GO:0031005 8.54853071818047e-07 2.45004618714207e-06 190 223 186 8.54853400666423e-08 32 2.69156570108472 3.07817953827504 1 20.1008569034406 186 55 769 71 303 354 279 236 32 39 129 133 M18812 GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. 10/35 Gene Ontology MF GO:0005217 7.77837154017544e-08 4.04299537681436e-07 190 217.090909090909 186 7.0712471047176e-09 77 1.79495008024727 1.99807891697981 1 15.2742550011665 271 144 186 88 147 414 294 77 188 424 155 134 M19094 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 9/18 Gene Ontology MF GO:0004675 1.2246519246899e-07 5.45374709994287e-07 190 230.545454545455 186 1.22465199217966e-08 51 2.08457547172649 2.06538503285896 1 17.3781678291614 250 108 891 68 186 309 190 51 88 153 242 135 M19099 GO_PURINERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_ACTIVITY.html Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 10/26 Gene Ontology MF GO:0035586 2.49483669374388e-06 5.88525579037018e-06 70 222.454545454545 187 2.26803592994072e-07 66 2.23355396634502 2.23355396634502 1 15.5489269602816 67 436 187 461 361 130 66 209 218 184 128 136 M19145 GO_PROTEIN_PHOSPHATASE_2A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_2A_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. 16/44 Gene Ontology MF GO:0051721 1.83044829442098e-06 4.55138494829e-06 80 200.909090909091 188 1.66404528854174e-07 28 2.13584586681428 2.4838670195884 1 15.1860532602464 188 295 284 70 344 278 100 76 28 470 77 137 M18897 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 67/180 Gene Ontology MF GO:0016614 4.71236721126483e-09 1.06280140710786e-07 390 264.545454545455 189 4.28397020123514e-10 4 1.40287338884325 -1.31165723077992 -1 13.0213213521854 389 118 315 460 4 98 486 189 531 166 154 138 M18474 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. 6/10 Gene Ontology MF GO:0016723 1.56389242946115e-05 3.02264923341231e-05 115 245.727272727273 190 1.56390343548805e-06 78 1.65387636991381 -1.65387636991381 -1 9.94917338965113 114 247 749 281 449 78 102 190 82 270 141 139 M18882 GO_HYALURONIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONIC_ACID_BINDING.html Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. 5/24 Gene Ontology MF GO:0005540 4.58536255775635e-08 2.95002346373136e-07 195 241.545454545455 191 4.58536265237133e-09 97 2.14525366493607 2.59633157896689 1 18.6460243034874 195 129 838 188 118 267 97 191 246 220 168 140 M19042 GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). 6/23 Gene Ontology MF GO:0005416 4.10438542088862e-09 9.93693312425666e-08 145 256.363636363636 191 4.10438542846931e-10 4 2.34357010932215 2.34357010932215 1 21.8438524526131 143 339 877 113 461 286 191 4 25 273 108 141 M17993 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 12/39 Gene Ontology MF GO:0001205 1.02598400781976e-05 2.03427863619435e-05 95 258.909090909091 193 9.32717084175223e-07 95 2.48091099360099 2.48091099360099 1 15.4922320708301 95 512 193 395 573 189 153 101 221 243 173 142 M18212 GO_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_ACTIVITY.html Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 7/14 Gene Ontology MF GO:0004707 6.12820397242675e-06 1.29014820472142e-05 155 279 193 6.12822087219011e-07 63 1.462096168747 -1.462096168747 -1 9.51504327477991 153 193 689 216 600 75 85 95 424 476 63 143 M18521 GO_PALMITOYL_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYL_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. 8/16 Gene Ontology MF GO:0016290 4.73639757515458e-09 1.06280140710786e-07 325 260.909090909091 193 4.73639758524963e-10 6 1.61707648015045 -0.946295842770194 -1 15.0095318085308 321 147 761 197 6 108 193 587 20 352 178 144 M19063 GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. 8/20 Gene Ontology MF GO:0004198 9.90601387919312e-07 2.77007075041267e-06 310 288.545454545455 193 9.90601829500588e-08 24 2.27765137675172 -1.63172992157476 -1 16.8480730875471 309 81 885 66 317 129 161 780 24 229 193 145 M18026 GO_PROTEIN_LIPID_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_BINDING.html Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. 8/37 Gene Ontology MF GO:0071814 0.000218455098180217 0.000348316621015251 35 274.090909090909 194 2.1847657633535e-05 31 2.66796924351763 2.66796924351763 1 12.2798154064013 31 297 643 175 598 194 138 183 364 226 166 146 M18383 GO_RECEPTOR_AGONIST_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_AGONIST_ACTIVITY.html Interacts with receptors such that the proportion of receptors in the active form is increased. 8/18 Gene Ontology MF GO:0048018 3.97275413691394e-08 2.66286179557615e-07 110 394.090909090909 199 3.97275420793643e-09 52 2.49504449080605 -3.08652684602881 -1 21.834026439106 858 109 729 100 108 910 647 199 52 76 547 147 M19120 GO_SEMAPHORIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with semaphorin receptors. 10/29 Gene Ontology MF GO:0030215 0.000697336503311797 0.00102483958953171 200 259 199 6.34143306357405e-05 35 2.57879762365796 2.57879762365796 1 10.2606755095043 35 423 156 269 644 199 109 338 181 298 197 148 M18548 GO_LIPOPOLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with lipopolysaccharide. 11/32 Gene Ontology MF GO:0001530 0.000127153516102394 0.000211539303461487 200 286.818181818182 200 1.15600787086898e-05 78 3.81437415220246 3.81437415220246 1 18.655943662672 198 678 167 78 540 331 256 167 79 461 200 149 M18721 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY.html Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. 10/21 Gene Ontology MF GO:0030228 3.87146286026835e-05 6.92946659814569e-05 140 315.363636363636 202 3.51957362749167e-06 110 1.6596271305327 1.90871732873581 1 9.1878430624704 140 523 185 366 583 202 110 133 639 423 165 150 M18082 GO_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. 82/349 Gene Ontology MF GO:0022836 1.96941282861622e-08 1.92751042800736e-07 195 214.454545454545 203 1.79037531476923e-09 15 1.80924003313456 1.9392408274717 1 16.1705658544007 191 88 31 80 203 401 225 649 213 15 263 151 M18217 GO_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 69/193 Gene Ontology MF GO:0016247 3.71490158735753e-08 2.58917383361282e-07 330 234.909090909091 203 3.37718331826096e-09 38 1.63589381718099 1.73522258842874 1 14.342172506321 177 38 67 203 102 326 317 644 326 52 332 152 M18746 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 11/23 Gene Ontology MF GO:0016638 1.76048522574607e-07 7.07269173662176e-07 205 283.909090909091 203 1.60044124238521e-08 72 2.66497114475843 3.40846003882909 1 21.8162328176318 377 173 72 91 202 624 573 222 203 121 465 153 M19050 GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. 80/201 Gene Ontology MF GO:0005057 3.931383140532e-07 1.30019172777559e-06 210 198.727272727273 207 3.57398531187939e-08 37 1.42070236766531 1.43031932504563 1 11.1302675006716 207 37 223 129 255 292 173 377 212 136 145 154 M19151 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS.html Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. 65/156 Gene Ontology MF GO:0016810 1.54438550872098e-07 6.45833940010593e-07 235 206.272727272727 207 1.40398692466894e-08 40 1.49076152063611 -1.35445259421534 -1 12.2821142702918 292 40 207 231 195 48 233 398 157 287 181 155 M18892 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. 24/49 Gene Ontology MF GO:0001105 1.61838532160191e-08 1.87474234565248e-07 365 264.272727272727 208 1.47125939409748e-09 47 1.99288921220648 1.85361206592822 1 17.843956604314 362 163 113 208 47 579 354 364 144 75 498 156 M18649 GO_CARGO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARGO_RECEPTOR_ACTIVITY.html Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis. 31/78 Gene Ontology MF GO:0038024 3.2574059043035e-10 1.10993090072564e-08 55 246 209 2.96127809525983e-11 26 2.13437802705406 2.06345297052293 1 22.5984253045628 51 200 26 377 204 281 209 534 456 43 325 157 M17945 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). 8/29 Gene Ontology MF GO:0005104 1.65224009298514e-07 6.84712110606456e-07 115 249.181818181818 211 1.65224021583053e-08 19 1.29432098910463 1.13629616151366 1 10.6199401771833 111 146 624 364 206 56 19 342 437 225 211 158 M18623 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other. 55/171 Gene Ontology MF GO:0005342 3.72125031261365e-07 1.24492737731075e-06 60 212.727272727273 211 3.38295540186808e-08 57 1.89844200949215 2.32570979823451 1 14.9207084074468 211 119 57 139 252 578 270 166 247 57 244 159 M19223 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. 38/152 Gene Ontology MF GO:0015081 9.74415857652817e-08 4.74318830180207e-07 245 219.454545454545 211 8.85832637101169e-09 32 2.04499514833837 2.18413061036595 1 17.2132197558716 243 211 58 32 160 503 239 376 146 100 346 160 M18156 GO_MHC_CLASS_II_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_RECEPTOR_ACTIVITY.html Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 5/10 Gene Ontology MF GO:0032395 3.36601144532618e-05 6.07202064647075e-05 120 257.363636363636 212 3.36606243156183e-06 50 2.83764541876496 2.83764541876496 1 15.9261281939591 119 238 677 212 493 154 50 173 339 218 158 161 M18689 GO_CHOLESTEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 4/18 Gene Ontology MF GO:0017127 8.86104024780137e-06 1.78775373420554e-05 195 260.909090909091 212 8.86107558111508e-07 11 4.12571403818039 4.12571403818039 1 26.0714088540472 193 249 798 54 430 390 212 116 11 336 81 162 M18909 GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a potassium channel. 26/60 Gene Ontology MF GO:0015459 2.73077639252871e-07 9.77554194990821e-07 215 256.636363636364 212 2.48252430135424e-08 69 1.71641920715047 1.89074103128304 1 13.7299973932725 212 97 91 85 235 491 390 717 174 69 262 163 M19143 GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. 12/30 Gene Ontology MF GO:0070001 3.76064541042727e-07 1.25354847014242e-06 155 198.181818181818 213 3.41876913933294e-08 51 1.44074129355877 -1.42954389856057 -1 11.3176852179325 154 51 239 213 253 142 184 292 233 249 170 164 M19214 GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. 10/25 Gene Ontology MF GO:0070273 2.78855525260487e-08 2.15926568991322e-07 530 302.454545454545 213 2.5350502617732e-09 81 1.50945579788306 1.89132402403886 1 13.3920962210015 530 191 213 136 88 690 397 81 172 299 530 165 M17916 GO_PROTEIN_SELF_ASSOCIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SELF_ASSOCIATION.html Interacting selectively and non-covalently with a domain within the same polypeptide. 27/71 Gene Ontology MF GO:0043621 2.41874591221427e-07 8.9727670936981e-07 90 223.818181818182 215 2.19886016194408e-08 36 1.72239787463792 1.81348105220038 1 13.8631375061091 86 449 256 453 233 215 132 36 207 252 143 166 M18360 GO_RECEPTOR_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. 18/40 Gene Ontology MF GO:0030546 5.7223033066364e-09 1.25345691478702e-07 420 297.454545454545 215 5.20209392865488e-10 7 2.41028042563033 2.2388048918734 1 22.1420819246788 420 215 87 39 7 696 394 721 64 94 535 167 M17911 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS.html Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). 24/77 Gene Ontology MF GO:0016782 9.58873358028624e-07 2.69774767396432e-06 220 284.636363636364 216 8.71703432686631e-08 139 1.70032243436573 1.55272107467509 1 12.6035007303016 216 142 139 146 304 399 319 643 177 194 452 168 M17913 GO_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLASE_ACTIVITY.html Catalysis of a ring closure reaction. 9/23 Gene Ontology MF GO:0009975 1.4127183138565e-06 3.65084508075275e-06 125 236.272727272727 219 1.41271921195517e-07 57 1.54745882131242 1.73284461190869 1 11.1997846224586 121 57 617 255 337 219 126 232 322 146 167 169 M17943 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION.html Any protein binding that is involved in cell adhesion. 10/21 Gene Ontology MF GO:0098631 8.92367146581288e-08 4.46183573290644e-07 350 250.181818181818 220 8.11242893434194e-09 56 2.57993031719393 2.414603682185 1 21.807093042958 346 220 189 56 153 355 242 678 63 293 157 170 M19159 GO_CYTOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_ACTIVITY.html Functions to control the survival, growth, differentiation and effector function of tissues and cells. 70/239 Gene Ontology MF GO:0005125 6.04590113643088e-11 2.41836045457235e-09 130 203.272727272727 220 5.49627376054277e-12 22 2.18264420418128 2.31086182208441 1 25.0320023281003 128 90 22 294 210 320 220 433 253 41 225 171 M19026 GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY.html Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 5/26 Gene Ontology MF GO:0001637 1.80566257465579e-06 4.50192295036133e-06 90 290.181818181818 221 1.80566404184527e-07 17 1.51751896371054 1.51751896371054 1 10.7992790506142 88 388 872 355 546 107 17 73 408 221 117 172 M18528 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the transforming growth factor beta receptor. 20/59 Gene Ontology MF GO:0005160 2.3347445529356e-07 8.78300076672582e-07 275 251.545454545455 222 2.12249527337257e-08 112 2.19167352015633 2.12605764379703 1 17.6672980887794 273 168 145 118 222 632 398 188 112 264 247 173 M18829 GO_ENZYME_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_REGULATOR_ACTIVITY.html Binds to and modulates the activity of an enzyme. 456/1178 Gene Ontology MF GO:0030234 3.89141267427565e-09 9.67594502792865e-08 5 257.272727272727 222 3.5376478919626e-10 2 1.67484804709099 1.99635896820093 1 15.6366226715335 330 2 49 155 3 920 342 245 222 77 485 174 M19177 GO_STRUCTURAL_MOLECULE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_MOLECULE_ACTIVITY.html The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. 349/949 Gene Ontology MF GO:0005198 2.78568061050681e-08 2.15926568991322e-07 40 233.727272727273 223 2.53243695070874e-09 36 1.97641230744003 2.46991265968083 1 17.5349979672315 240 251 37 36 87 837 383 223 119 49 309 175 M18176 GO_INSULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin receptor. 17/46 Gene Ontology MF GO:0005158 5.26438092364633e-07 1.6312908166692e-06 230 208.454545454545 226 4.78580198487335e-08 50 2.40142035164259 2.66526610837361 1 18.4986331445027 112 332 226 242 329 228 174 50 104 378 118 176 M18942 GO_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 8/22 Gene Ontology MF GO:0016502 8.62454938082115e-06 1.75604477947358e-05 95 322.636363636364 227 8.62458285328738e-07 63 2.0865234618148 2.0865234618148 1 13.2068425987792 93 502 859 569 425 128 63 225 327 227 131 177 M17884 GO_NEUROTRANSMITTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BINDING.html Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 5/32 Gene Ontology MF GO:0042165 1.93707766899876e-06 4.73965812627357e-06 315 287.363636363636 228 1.93707935752229e-07 103 1.64110160607742 1.70269816705044 1 11.6299257336443 314 222 613 201 354 342 164 405 103 215 228 178 M18047 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS.html Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). 32/68 Gene Ontology MF GO:0016765 1.8003925225502e-07 7.20157009020082e-07 80 298.818181818182 228 1.63672060898835e-08 79 1.01719494839622 -1.12131169248739 -1 8.31643654126119 152 228 424 580 205 80 272 220 621 426 79 179 M18598 GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY.html Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. 7/18 Gene Ontology MF GO:0005041 2.19590615505444e-07 8.51496019772218e-07 55 257.363636363636 228 2.19590637204464e-08 23 1.90871732873581 1.90871732873581 1 15.4205562534691 54 373 777 228 509 42 23 35 435 309 46 180 M19041 GO_NOTCH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_BINDING.html Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. 8/30 Gene Ontology MF GO:0005112 4.26133091649618e-06 9.38558948774613e-06 460 337.545454545455 228 4.26133908804177e-07 50 2.02626586490051 2.6436138604229 1 13.5592173642501 457 204 876 50 392 742 467 96 62 228 139 181 M19182 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 21/89 Gene Ontology MF GO:0004869 2.59340497260331e-07 9.40916799652439e-07 230 434.545454545455 229 2.3576411621084e-08 132 2.0803461531026 -2.0891128113006 -1 16.6870618305965 824 229 163 132 227 859 496 919 140 133 658 182 M18302 GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. 15/37 Gene Ontology MF GO:0015175 1.16556998313844e-07 5.2564920808204e-07 300 233 230 1.05960913171897e-08 123 2.05459551261382 2.31925133296455 1 17.1719907409013 300 343 123 204 174 412 230 238 261 142 136 183 M18708 GO_PEPTIDE_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_BINDING.html Interacting selectively and non-covalently with any peptide with hormonal activity in animals. 11/55 Gene Ontology MF GO:0017046 2.21513429200579e-07 8.51496019772218e-07 175 262.636363636364 231 2.01375865003918e-08 105 2.05572125235778 1.72166349091773 1 16.6082032737686 175 105 119 290 217 245 231 626 225 317 339 184 M17965 GO_TAU_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_BINDING.html Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. 12/20 Gene Ontology MF GO:0048156 6.94333965871031e-05 0.000119847513808883 220 341.545454545455 232 6.31232618600058e-06 80 2.42087567728407 3.07535471845757 1 12.6355225783531 218 777 232 332 894 291 80 151 128 490 164 185 M18659 GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). 13/28 Gene Ontology MF GO:0036442 2.44050753065666e-06 5.78677043351579e-06 90 277.272727272727 233 2.21864567088054e-07 39 1.13149476168277 -1.13149476168277 -1 7.88795885352066 89 377 449 233 359 39 116 126 529 642 91 186 M18414 GO_STEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 6/25 Gene Ontology MF GO:0015248 2.47230338699703e-07 9.13461492384443e-07 540 364.636363636364 234 2.47230366204985e-08 12 3.01401990339839 4.12571403818039 1 24.2279256407604 540 194 735 67 234 876 637 144 12 434 138 187 M18509 GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 8/22 Gene Ontology MF GO:0099604 1.83421765397396e-08 1.87497804628449e-07 235 227.454545454545 235 1.83421766911355e-09 12 1.79495008024727 1.99807891697981 1 16.0715161460321 235 128 756 43 271 310 247 12 78 351 71 188 M19079 GO_SODIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_BINDING.html Interacting selectively and non-covalently with sodium ions (Na+). 8/30 Gene Ontology MF GO:0031402 2.77733351442811e-07 9.86543178870218e-07 180 299.818181818182 235 2.77733386153934e-08 38 1.98322206354406 -1.98322206354406 -1 15.853716139566 178 299 889 235 433 133 211 38 366 356 160 189 M18179 GO_METALLOCARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOCARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 6/28 Gene Ontology MF GO:0004181 8.5252698348379e-07 2.45004618714207e-06 170 286.181818181818 236 8.52527310544982e-08 60 2.63406285518508 3.61660701609985 1 19.6714204067902 169 361 681 385 511 236 99 60 67 431 148 190 M18665 GO_WIDE_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WIDE_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. 13/27 Gene Ontology MF GO:0022829 0.00017663772785765 0.000285063361238608 130 302.363636363636 238 1.60592646975763e-05 116 2.49803252172859 2.60312045782163 1 11.787027452485 129 478 116 448 532 238 178 277 564 175 191 191 M18733 GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING.html Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. 21/54 Gene Ontology MF GO:0043548 9.98255212836521e-06 1.98357407302289e-05 295 253.545454545455 238 9.07508856792707e-07 122 1.7140846881106 2.11638567592645 1 10.7287376897711 199 165 177 122 431 293 238 316 190 292 366 192 M18059 GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. 6/19 Gene Ontology MF GO:0015269 3.99429269336422e-08 2.66286179557615e-07 110 270.181818181818 239 3.99429276515891e-09 21 2.08916178721373 2.52620133254727 1 18.2821642596867 414 59 655 21 109 613 395 239 107 267 93 193 M18684 GO_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. 19/59 Gene Ontology MF GO:0008146 2.4576814934804e-06 5.8125115012904e-06 205 242.454545454545 239 2.23425839911762e-07 122 1.79192006155648 1.6567159558486 1 12.4873671946596 122 203 130 304 360 249 180 371 202 239 307 194 M18994 GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. 44/84 Gene Ontology MF GO:0050660 1.13754183436873e-07 5.17191397341457e-07 215 218.272727272727 239 1.03412899380635e-08 4 1.41114198942608 -1.26812910460494 -1 11.8073373401188 208 303 251 239 260 23 213 213 349 338 4 195 M18141 GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. 5/14 Gene Ontology MF GO:0015172 5.54859486966732e-06 1.18714122792882e-05 235 311.818181818182 241 5.54860872382328e-07 14 3.45070921143932 3.45070921143932 1 22.6225358751421 233 589 672 241 405 335 201 172 14 383 185 196 M18813 GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS.html Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 33/63 Gene Ontology MF GO:0016879 1.35533695942413e-05 2.65300000568127e-05 85 318.545454545455 241 1.23213209928688e-06 69 1.22553192173907 -1.22974474372507 -1 7.46480286358412 84 241 341 731 439 69 152 171 582 532 162 197 M18581 GO_IDENTICAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IDENTICAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with an identical protein or proteins. 696/1724 Gene Ontology MF GO:0042802 1.47477904393785e-08 1.87474234565248e-07 215 290.727272727273 243 1.47477905372523e-09 28 1.74110951149929 1.95610062425452 1 15.5895681895415 213 131 773 211 48 685 282 243 288 28 296 198 M18540 GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of potassium ions (K+) from one side of a membrane to the other. 45/152 Gene Ontology MF GO:0015079 3.43251931536781e-07 1.17832752617104e-06 165 242.909090909091 244 3.12047259174724e-08 70 1.72662309308606 1.79584884773902 1 13.6251817330183 163 254 78 134 244 368 208 543 350 70 260 199 M18498 GO_CALMODULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_BINDING.html Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. 71/244 Gene Ontology MF GO:0005516 3.79269755589235e-07 1.25966850231804e-06 255 235.636363636364 245 3.44790746339628e-08 69 1.8691743749419 1.96587395648594 1 14.6779621392318 69 534 144 402 254 158 147 89 299 251 245 200 M18781 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. 9/20 Gene Ontology MF GO:0019198 1.98328496502844e-06 4.8398465990084e-06 120 321.272727272727 246 1.98328673506933e-07 33 1.30831020723933 1.61203990778111 1 9.25572697694675 120 246 817 161 357 153 33 275 579 550 243 201 M18295 GO_CATION_SUGAR_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_SUGAR_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). 13/16 Gene Ontology MF GO:0005402 3.0679847918692e-06 7.0918241420092e-06 605 300.818181818182 247 2.78908097300053e-07 103 1.4820981537912 -1.22256663345 -1 10.1578794480286 602 103 247 140 371 343 547 109 196 174 477 202 M19084 GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING.html Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. 147/461 Gene Ontology MF GO:0001159 5.61870633154721e-08 3.27777371727131e-07 245 307.909090909091 248 5.10791497731508e-09 126 1.58346871789424 1.76608692048183 1 13.6666945618371 244 154 197 337 126 573 297 429 248 191 591 203 M18125 GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. 11/36 Gene Ontology MF GO:0005227 3.6451575709821e-07 1.2329209431263e-06 115 330.909090909091 250 3.31378015904061e-08 22 2.00422729684221 2.36846677578814 1 15.7633501561626 586 54 115 22 250 919 666 439 114 205 270 204 M18574 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 131/414 Gene Ontology MF GO:0000982 2.59716196663818e-07 9.40916799652439e-07 185 283.181818181818 250 2.36105661203683e-08 115 1.51244832578293 1.63544435856423 1 12.1317877876479 184 115 183 298 228 415 250 467 323 130 522 205 M18611 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS.html Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). 14/33 Gene Ontology MF GO:0016769 2.25368800305383e-07 8.53248132843426e-07 585 365.545454545455 251 2.04880748538408e-08 47 1.77847301125063 2.15865826790956 1 14.3661971222792 583 169 160 73 221 911 629 251 47 302 675 206 M19217 GO_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 11/37 Gene Ontology MF GO:0005272 3.69677302849245e-07 1.24492737731075e-06 405 282.454545454545 251 3.36070331789124e-08 142 1.99315171921251 -1.7812239607841 -1 15.6650746126662 403 172 164 142 251 275 540 436 166 208 350 207 M18807 GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in). 2/12 Gene Ontology MF GO:0043225 0.000864450849060477 0.00125440817213823 205 342.6 252.5 9.60870169205181e-05 105 1.39908541223116 1.39908541223116 1 5.40329512806724 202 250 822 NA 624 239 105 255 379 190 360 208 M18145 GO_ADRENERGIC_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an adrenergic receptor. 7/30 Gene Ontology MF GO:0031690 4.95087405433644e-06 1.06920284741538e-05 255 305.181818181818 253 4.95088508439028e-07 77 0.914370286858581 -0.914370286858581 -1 6.04983268502977 103 289 674 253 396 77 157 253 395 653 107 209 M18237 GO_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_ACTIVITY.html The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. 25/137 Gene Ontology MF GO:0005179 2.13604858085799e-07 8.36240295484829e-07 150 289.090909090909 253 1.94186253477603e-08 86 2.60071324255148 2.50595282484496 1 21.0383809307263 148 420 86 540 215 253 124 524 384 210 276 210 M18247 GO_ICOSANOID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_RECEPTOR_ACTIVITY.html Combining with an icosanoid to initiate a change in cell activity. 4/14 Gene Ontology MF GO:0004953 0.00143326482342929 0.00199735419616827 130 306.909090909091 254 0.000143419007504677 94 1.95497085413559 1.95497085413559 1 7.02447066999951 94 326 696 130 622 177 130 254 374 334 239 211 M18426 GO_COPPER_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_BINDING.html Interacting selectively and non-covalently with copper (Cu) ions. 27/68 Gene Ontology MF GO:0005507 1.72159060588029e-07 6.9899320908768e-07 315 276.909090909091 254 1.56508249145624e-08 38 2.64973254857054 3.2074498624017 1 21.709513577665 311 308 90 38 200 638 485 134 113 254 475 212 M18143 GO_LYSOPHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPASE_ACTIVITY.html Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. 9/23 Gene Ontology MF GO:0004622 1.26292210285959e-07 5.50657978498022e-07 580 363.454545454545 256 1.26292217463335e-08 56 1.86472110077213 -0.914338047366855 -1 15.5349488622332 578 56 673 205 189 738 437 150 65 256 651 213 M18575 GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 176/580 Gene Ontology MF GO:0022890 4.94368536282739e-08 3.03212702253413e-07 45 328.454545454545 256 4.49425952174401e-09 32 1.66307778859809 1.8434177699605 1 14.4286781855136 357 32 43 64 117 869 491 838 256 42 504 214 M19009 GO_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. 52/156 Gene Ontology MF GO:0015293 3.94297273966727e-07 1.30019172777559e-06 420 369.272727272727 256 3.58452131486438e-08 141 1.71037368724829 2.01593180745606 1 13.3996517793318 419 160 146 141 256 809 469 719 187 169 587 215 M18365 GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. 6/13 Gene Ontology MF GO:0004859 3.71793922218801e-07 1.24492737731075e-06 225 283.545454545455 258 3.7179398442264e-08 122 1.56135811253958 1.6608142852904 1 12.2714144548418 222 175 724 411 258 274 122 318 204 269 142 216 M18393 GO_SH2_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH2_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. 21/52 Gene Ontology MF GO:0042169 3.55547854301706e-07 1.20702592604269e-06 275 261.181818181818 258 3.23225374329776e-08 109 1.47811741144205 1.75381345986555 1 11.6436053962015 219 258 271 109 248 439 275 174 375 291 214 217 M17892 GO_PROTEIN_COMPLEX_SCAFFOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SCAFFOLD.html Functions to provide a physical support for the assembly of a multiprotein complex. 34/90 Gene Ontology MF GO:0032947 1.68435986364817e-07 6.94892858545433e-07 180 402 261 1.53123635691439e-08 95 1.39691199325766 -1.2086148606676 -1 11.4497844704288 856 95 261 177 199 562 837 561 178 125 571 218 M17995 GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 4/15 Gene Ontology MF GO:0001608 0.000444254802911416 0.000672227662300169 190 350.818181818182 262 4.44343640956488e-05 175 2.55643578659635 2.55643578659635 1 10.7948611740258 187 601 633 420 587 257 262 221 175 330 186 219 M18052 GO_VIRUS_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRUS_RECEPTOR_ACTIVITY.html Combining with a virus component and mediating entry of the virus into the cell. 44/110 Gene Ontology MF GO:0001618 2.21143402762364e-08 1.97762447895865e-07 80 243.909090909091 264 2.01039459077537e-09 69 1.90982932731379 2.06668885832506 1 17.0412735636536 80 410 99 264 69 314 181 279 495 285 207 220 M18663 GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 68/213 Gene Ontology MF GO:0008514 5.26623231033426e-07 1.6312908166692e-06 285 256.272727272727 264 4.78748506448618e-08 50 1.75535655624165 2.12870170845408 1 13.5218709973662 285 89 66 163 274 700 322 264 245 50 361 221 M18916 GO_STEROID_HYDROXYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HYDROXYLASE_ACTIVITY.html Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. 7/72 Gene Ontology MF GO:0008395 0.00074790112426633 0.00109390943453899 180 332.727272727273 264 7.48152953800041e-05 176 1.6439353827819 1.68720801668425 1 6.4790097866465 176 206 849 363 595 259 264 230 264 180 274 222 M18606 GO_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. 20/49 Gene Ontology MF GO:0008374 1.00903583048828e-06 2.79551616010918e-06 520 261.545454545455 266 9.17305721168666e-08 73 1.41589781721243 -1.38522232754763 -1 10.4660894610955 519 73 266 305 308 201 400 80 109 358 258 223 M18966 GO_PROTEIN_DOMAIN_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DOMAIN_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a specific domain of a protein. 375/931 Gene Ontology MF GO:0019904 1.07163579919797e-08 1.69983609527953e-07 265 273.727272727273 266 9.74214367652707e-10 26 1.58459600962824 1.79170820771241 1 14.2778860001449 262 266 135 187 26 609 271 470 342 127 316 224 M18304 GO_GLUCOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_BINDING.html Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. 6/16 Gene Ontology MF GO:0005536 0.000496485125604253 0.000747571711220807 625 401.727272727273 267 4.96596084361753e-05 87 1.97554943233383 1.97554943233383 1 8.22068240203675 151 627 708 650 625 198 87 233 249 624 267 225 M18621 GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR.html Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. 6/11 Gene Ontology MF GO:0016884 9.43377647226337e-07 2.66229274677371e-06 135 289.363636363636 267 9.43378047709199e-08 31 1.60225787342075 -1.60225787342075 -1 11.8888581947899 133 275 779 297 563 139 267 61 31 439 199 226 M18690 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 85/280 Gene Ontology MF GO:0001077 4.58380483206825e-07 1.4693729775271e-06 275 316.454545454545 267 4.16709617011463e-08 135 1.57650463411221 1.74368166603632 1 12.239401641387 275 135 209 267 264 483 232 503 291 230 592 227 M18245 GO_SCAVENGER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAVENGER_RECEPTOR_ACTIVITY.html Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). 18/49 Gene Ontology MF GO:0005044 3.87812583041967e-09 9.67594502792865e-08 50 241.727272727273 268 3.52556894295999e-10 30 2.27759070330229 2.10987366305907 1 21.2639153770108 48 166 30 311 295 268 223 580 356 44 338 228 M18703 GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 24/96 Gene Ontology MF GO:0005249 1.10703863879047e-06 2.97799867744806e-06 115 253.272727272727 269 1.00639926895639e-07 56 1.72028238420469 1.83849438732338 1 12.6531701429647 126 459 114 314 319 269 113 315 433 56 268 229 M18067 GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 27/145 Gene Ontology MF GO:0015103 1.54144231698691e-08 1.87474234565248e-07 330 325 270 1.40131120707919e-09 44 1.562736531317 1.5456558639691 1 13.9924498400401 327 257 225 270 44 431 166 917 399 253 286 230 M18121 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 118/368 Gene Ontology MF GO:0001228 5.19185770983777e-08 3.1496417786705e-07 120 294 270 4.71987075669297e-09 83 1.72391276667824 1.86053661004506 1 14.9185840157027 270 117 93 224 119 540 296 572 298 83 622 231 M18238 GO_STEROID_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_ACTIVITY.html Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. 19/63 Gene Ontology MF GO:0003707 4.89149190508424e-07 1.53067093628487e-06 610 325.636363636364 270 4.44681181151048e-08 111 1.92979034502299 -2.44582059648409 -1 14.9365903816055 610 286 142 259 270 514 761 169 156 111 304 232 M18624 GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY.html Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 5/14 Gene Ontology MF GO:0004467 7.23795916100348e-07 2.12745125499144e-06 100 292.545454545455 270 7.23796151846695e-08 42 2.06944143465104 -2.06944143465104 -1 15.6236647193627 196 417 780 353 293 100 72 270 42 596 99 233 M18805 GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. 21/74 Gene Ontology MF GO:0008028 3.1403651673866e-05 5.72106129504093e-05 165 278.363636363636 272 2.85491817733687e-06 97 2.05452743172633 2.2805246930166 1 11.6016291367298 164 272 97 190 471 363 198 425 371 132 379 234 M17979 GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 121/397 Gene Ontology MF GO:0015077 1.37101851574306e-07 5.89409829197951e-07 75 406.181818181818 273 1.24638054653055e-08 74 1.68120106615495 1.91059026085314 1 13.9399559875902 742 157 74 75 188 502 776 680 273 107 894 235 M18216 GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of cation from one side of the membrane to the other. 221/681 Gene Ontology MF GO:0008324 1.02092640775015e-07 4.89193903713612e-07 475 347.090909090909 274 9.28114959206366e-09 3 1.62904022360853 1.85050810587478 1 13.6829480698104 472 3 45 90 162 760 562 769 274 25 656 236 M18978 GO_FATTY_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. 5/20 Gene Ontology MF GO:0015645 7.23795916100348e-07 2.12745125499144e-06 200 301.363636363636 274 7.23796151846695e-08 43 2.06944143465104 -2.06944143465104 -1 15.6236647193627 197 418 864 354 294 101 73 274 43 597 100 237 M18578 GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a negatively charged ion from one side of a membrane to the other. 98/337 Gene Ontology MF GO:0008509 5.33451915594725e-08 3.20768472122319e-07 280 256.909090909091 276 4.84956298663425e-09 36 1.6547320120845 1.94519916788163 1 14.302433283977 296 36 69 186 122 710 276 493 279 53 306 238 M18801 GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-specific protease. 6/13 Gene Ontology MF GO:1990381 0.000118692817059926 0.000197821361766543 150 383.909090909091 276 1.18699157129697e-05 103 0.645122366364496 -0.645122366364496 -1 3.18026796851213 181 276 820 341 647 103 150 170 500 886 149 239 M18445 GO_PYRIDOXAL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDOXAL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. 25/53 Gene Ontology MF GO:0030170 5.52267541391099e-07 1.69362046026604e-06 565 352.818181818182 277 5.02061527297505e-08 138 1.56148507698181 -1.54762956215791 -1 11.9945937009461 562 141 196 138 277 386 686 709 205 211 370 240 M18848 GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). 21/28 Gene Ontology MF GO:0015295 6.26738886103797e-07 1.89670978689307e-06 665 330.909090909091 277 5.69762786045513e-08 184 1.42818864469958 -1.06411884678893 -1 10.8771757802634 662 184 263 215 284 322 553 224 277 200 456 241 M17881 GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. 62/204 Gene Ontology MF GO:0022853 4.86704832027294e-08 3.00515735211484e-07 510 414 278 4.42458947995127e-09 87 1.69317720671318 1.9557542897474 1 14.6985619450958 510 210 132 87 116 852 619 890 278 195 665 242 M17869 GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. 9/21 Gene Ontology MF GO:0034237 1.45614157630087e-05 2.8382420555017e-05 130 349.727272727273 279 1.45615111795617e-06 92 1.93146045558736 1.93146045558736 1 11.6893090796763 130 668 611 435 446 279 215 194 92 544 233 243 M18399 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS.html Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). 114/262 Gene Ontology MF GO:0016746 8.76026636198673e-08 4.40406833498786e-07 145 347.727272727273 279 7.96387882801382e-09 12 1.13523009900118 -1.07764825088848 -1 9.60418544102649 142 357 564 884 279 12 127 123 539 758 40 244 M18494 GO_PHOSPHATIDYLSERINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_BINDING.html Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. 25/62 Gene Ontology MF GO:0001786 0.0001653791139503 0.000268814107481053 185 327.636363636364 279 1.5035595199203e-05 165 2.10713820732402 2.24141779345478 1 10.0140711261021 165 649 182 234 527 284 204 182 527 371 279 245 M18822 GO_GTPASE_ACTIVATING_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVATING_PROTEIN_BINDING.html Interacting selectively and non-covalently with a GTPase activating protein. 13/36 Gene Ontology MF GO:0032794 9.86488286780904e-09 1.62065932828291e-07 280 278.636363636364 279 8.96807537458502e-10 5 1.7450288551326 1.99712187639898 1 15.7715691042885 279 368 279 356 437 345 249 5 131 390 226 246 M18566 GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. 13/29 Gene Ontology MF GO:0015665 4.45685719461791e-06 9.76263956916305e-06 710 385 282 4.05169656685611e-07 48 2.61940372938068 -2.6146924105632 -1 17.4686957662735 708 125 48 171 388 593 920 261 255 282 484 247 M17973 GO_PROTEIN_HETERODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETERODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. 238/584 Gene Ontology MF GO:0046982 8.51166841179204e-08 4.33472025296942e-07 420 342.454545454545 283 7.73788067373036e-09 50 1.82703525844794 2.17141546475291 1 15.4737048070916 417 133 50 202 151 732 654 593 283 51 501 248 M18266 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a protein serine/threonine kinase. 15/25 Gene Ontology MF GO:0043539 2.40801670641519e-06 5.72448415995342e-06 215 246 283 2.1891084928375e-07 36 1.27456326761592 -1.22493566212486 -1 8.89330180895924 215 288 326 283 362 61 192 139 480 324 36 249 M18487 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. 33/74 Gene Ontology MF GO:0098811 6.88473582334724e-08 3.70406839618682e-07 285 289.818181818182 284 6.25885094436355e-09 119 1.78884301560131 1.59936590730713 1 15.3128213269206 284 139 153 275 141 468 318 575 284 119 432 250 M18199 GO_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 20/52 Gene Ontology MF GO:0005504 0.000101628106396255 0.000170928442202111 260 284.818181818182 285 9.23934557899896e-06 82 2.56975170734205 2.82410489364055 1 12.8851945583239 256 330 82 107 510 388 285 432 300 188 255 251 M18632 GO_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BINDING.html Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. 22/96 Gene Ontology MF GO:0042562 1.86457552502603e-06 4.60387008875495e-06 760 380.090909090909 285 1.69507009574515e-07 21 1.82935705657205 -2.03433136972987 -1 12.9947659384676 756 21 80 206 346 674 867 285 189 231 526 252 M18068 GO_PROTEIN_KINASE_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_BINDING.html Interacting selectively and non-covalently with any subunit of protein kinase A. 18/48 Gene Ontology MF GO:0051018 3.53937108479365e-06 8.05995395547069e-06 100 298.636363636364 286 3.2176152536041e-07 99 1.56966769721829 1.65452534329849 1 10.6419469989419 99 596 353 495 376 186 143 211 286 413 127 253 M18527 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS.html Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). 120/288 Gene Ontology MF GO:0016757 9.25129145835105e-09 1.60588455503452e-07 260 319.909090909091 286 8.41026499750356e-10 21 1.4376937532909 1.91886918986015 1 13.0014856840161 260 209 286 351 21 764 425 62 240 581 320 254 M18862 GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. 10/43 Gene Ontology MF GO:0005310 2.57175961264054e-05 4.74789236719016e-05 325 283.818181818182 287 2.33799061502756e-06 122 2.05788988169144 2.42489731183524 1 11.8424155678594 323 385 204 180 495 434 287 122 143 296 253 255 M18420 GO_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. 26/149 Gene Ontology MF GO:0004497 1.32919356520629e-06 3.48392615381705e-06 295 340.090909090909 291 1.20835851661606e-07 83 2.07784708176982 2.49601092761855 1 15.0946979311034 291 282 83 124 331 634 533 484 185 167 627 256 M18374 GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY.html Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. 7/12 Gene Ontology MF GO:0031543 0.00128918994042805 0.00181910236992916 275 346.818181818182 292 0.000128993845647004 170 1.48531630519187 1.61993252758809 1 5.41720027243447 272 323 727 266 631 419 292 307 170 179 229 257 M18662 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. 5/31 Gene Ontology MF GO:0043395 3.49644469886944e-06 7.98195812148856e-06 240 342.090909090909 292 3.49645020018811e-07 85 2.38773029667613 2.38773029667613 1 16.2016250814544 236 464 794 244 552 264 151 85 297 384 292 258 M18024 GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING.html A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors. 16/51 Gene Ontology MF GO:0098531 1.65485348888351e-06 4.15974101030828e-06 410 298.454545454545 293 1.50441339425069e-07 136 1.93491977244751 -2.23379043589558 -1 13.8580906991357 406 243 172 192 342 411 597 293 136 170 321 259 M18408 GO_ADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_BINDING.html Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. 26/67 Gene Ontology MF GO:0043531 4.486287155839e-06 9.80376290587144e-06 405 274.818181818182 293 4.0784511858164e-07 35 2.65876037915372 2.94877275580631 1 17.7247033385552 293 98 155 35 389 600 409 200 39 404 401 260 M18226 GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. 32/94 Gene Ontology MF GO:0008081 2.62814635458617e-07 9.48193978909519e-07 250 354.181818181818 294 2.3892242441343e-08 104 1.96114905005516 1.91652878526344 1 15.7222130680261 247 736 188 648 231 294 104 549 301 155 443 261 M19061 GO_GAMMA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_CATENIN_BINDING.html Interacting selectively and non-covalently with the gamma subunit of the catenin complex. 7/21 Gene Ontology MF GO:0045295 2.02165286219855e-05 3.81131277299727e-05 230 324.363636363636 294 2.02167125429536e-06 48 2.39343659607454 3.05887509289473 1 14.0773657307423 227 337 884 273 459 385 218 130 48 313 294 262 M18106 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a lipoprotein particle receptor. 11/30 Gene Ontology MF GO:0070325 7.96799316546988e-06 1.63994490206539e-05 185 393.545454545455 295 7.24365638564907e-07 97 2.01635789535923 2.01635789535923 1 12.8424490398238 185 778 339 513 797 287 156 97 295 599 283 263 M18188 GO_FAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 10/15 Gene Ontology MF GO:0071949 6.28864506199648e-08 3.50639603456773e-07 410 308.272727272727 295 5.71695021977804e-09 132 1.54460212888253 -1.27228069300764 -1 13.2710419900943 409 468 297 226 132 283 373 146 473 295 289 264 M18878 GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. 73/254 Gene Ontology MF GO:0015291 5.14881335990235e-07 1.60573162410514e-06 300 310.909090909091 297 4.68074051355947e-08 118 1.63819651057618 1.89982074275779 1 12.6343176535461 297 136 122 251 272 677 310 462 331 118 444 265 M18411 GO_CATION_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 30/70 Gene Ontology MF GO:0019829 8.73392095242423e-07 2.49540598640692e-06 165 275.090909090909 299 7.93993129069219e-08 58 1.5653933708556 -1.51012110297867 -1 11.6738996382068 370 227 306 58 299 162 411 163 335 472 223 266 M18593 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 47/117 Gene Ontology MF GO:0001191 2.36945325347765e-08 1.99990549834811e-07 280 306.090909090909 300 2.15404843545204e-09 14 1.51460182636619 1.45577880704818 1 13.5048770265284 276 14 230 390 77 523 300 631 324 198 404 267 M18465 GO_MOLECULAR_FUNCTION_REGULATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLECULAR_FUNCTION_REGULATOR.html A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators. 622/1627 Gene Ontology MF GO:0098772 4.61010323044667e-09 1.06280140710786e-07 305 337.818181818182 301 4.61010324001053e-10 5 1.62597913926607 1.84516084951568 1 15.0921653496013 301 31 746 137 5 874 367 392 254 23 586 268 M17950 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of hydrogen ions from one side of a membrane to the other. 42/114 Gene Ontology MF GO:0015078 2.04897880583384e-05 3.85492945064853e-05 105 322.363636363636 302 1.86272535393526e-06 52 1.11064843396931 -1.02216298306681 -1 6.52514360115102 102 317 525 302 496 52 117 273 462 765 135 269 M18132 GO_GTPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. 8/20 Gene Ontology MF GO:0005095 6.5054495123151e-05 0.000112712119610732 240 363.454545454545 302 6.50563996409208e-06 144 1.77341100123742 -1.77341100123742 -1 9.31906951885092 239 544 668 299 630 193 316 153 302 510 144 270 M18500 GO_MAP_KINASE_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_KINASE_ACTIVITY.html Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. 8/25 Gene Ontology MF GO:0004709 3.99019733103835e-07 1.30639912617626e-06 240 350.909090909091 304 3.99019804751389e-08 170 1.18802935261799 -0.652775133946666 -1 9.3041565920932 237 235 754 403 261 304 170 227 406 516 347 271 M18755 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. 54/216 Gene Ontology MF GO:0016705 4.00955965663e-06 8.95614922539598e-06 185 280.090909090909 304 3.64506087652713e-07 89 1.77684935884548 1.99747062884614 1 11.9382950357029 182 438 140 172 382 472 304 333 226 89 343 272 M18770 GO_TRANSCRIPTION_COACTIVATOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_BINDING.html Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 3/12 Gene Ontology MF GO:0001223 8.71665678127331e-05 0.000148781525765704 505 366.181818181818 306 8.71699871062433e-06 180 2.72555383992707 -2.72555383992707 -1 13.8850420444714 306 434 813 368 503 258 255 180 191 504 216 273 M17849 GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. 7/25 Gene Ontology MF GO:0004112 1.06324645801126e-05 2.10362740079648e-05 205 396.727272727273 307 1.06325154526416e-06 42 1.49890697042174 1.49890697042174 1 9.330989948781 201 728 608 777 712 169 42 104 560 307 156 274 M19011 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery. 53/114 Gene Ontology MF GO:0001104 1.80441264005346e-08 1.87474234565248e-07 795 411.909090909091 310 1.64037514077548e-09 43 1.51559596494206 1.56117220609227 1 13.5703620132496 792 43 301 321 55 542 880 310 223 290 774 275 M19137 GO_AMMONIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_BINDING.html Interacting selectively and non-covalently with ammonium ions (NH4+). 16/79 Gene Ontology MF GO:0070405 6.6144240333163e-08 3.62218458967321e-07 310 321.454545454545 310 6.01311293834789e-09 137 1.8162727376316 -1.0864522290477 -1 15.5710947136658 333 309 181 491 137 475 290 357 391 262 310 276 M17861 GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. 16/32 Gene Ontology MF GO:0035250 8.43173177115718e-07 2.43172201550615e-06 675 448.363636363636 311 7.66521363882632e-08 159 2.24968330166555 2.7729483574803 1 16.810601501871 674 619 159 196 298 846 710 165 311 259 695 277 M18038 GO_ADENYLYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an adenylyl group to an acceptor. 14/34 Gene Ontology MF GO:0070566 1.04604715857332e-06 2.84722895232974e-06 190 334.545454545455 313 9.50952414494501e-08 89 0.86581640495848 -0.903344107662796 -1 6.39080180985874 189 333 459 477 313 89 142 290 642 536 210 278 M18022 GO_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_ACTIVITY.html The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. 2/12 Gene Ontology MF GO:0009881 1.02025453512236e-07 4.89193903713612e-07 550 356 314.5 1.13361620153938e-08 4 3.15444836779226 -1.27365440468027 -1 26.4954507502618 547 150 640 NA 440 813 742 25 4 189 10 279 M18817 GO_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_A2_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. 7/33 Gene Ontology MF GO:0004623 9.19217243591208e-06 1.84646258537972e-05 260 397.090909090909 316 9.19221045934878e-07 95 1.51678952057039 1.81208561505572 1 9.55663748272415 257 424 824 313 432 244 95 872 316 481 110 280 M18787 GO_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 37/84 Gene Ontology MF GO:0019209 1.3277992004102e-07 5.76214747347821e-07 185 424.909090909091 318 1.20709025504443e-08 168 1.68534183963839 -1.24939281769423 -1 13.9963474375271 645 318 229 181 184 739 598 740 184 168 688 281 M19037 GO_ACID_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. 3/12 Gene Ontology MF GO:0003993 0.000130539336617112 0.000216389530968906 320 469.636363636364 318 1.30547005484424e-05 65 0.62271462984827 -0.62271462984827 -1 3.0375099919107 318 277 873 479 729 233 65 206 865 900 221 282 M18269 GO_L_ASCORBIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_BINDING.html Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 13/21 Gene Ontology MF GO:0031418 0.0144892534275949 0.017797213822947 320 390.272727272727 319 0.00132596084137007 173 1.6792443522857 1.98466935543715 1 3.91063494762911 319 581 293 272 713 551 306 495 234 173 356 283 M18537 GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. 125/394 Gene Ontology MF GO:0022804 1.49241115276463e-07 6.32727309006203e-07 110 428.636363636364 319 1.35673750364104e-08 107 1.69457840689561 1.99036282006978 1 13.9814085500327 665 225 107 198 192 603 720 750 319 108 828 284 M18475 GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES.html Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance. 52/130 Gene Ontology MF GO:0043492 8.20782462822181e-07 2.39459148875896e-06 500 346.363636363636 322 7.46166153674795e-08 195 1.66632778161341 -1.50808585177515 -1 12.4663389177624 500 400 282 252 296 195 546 244 354 322 419 285 M18178 GO_CIS_TRANS_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_TRANS_ISOMERASE_ACTIVITY.html Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. 16/44 Gene Ontology MF GO:0016859 1.13622978643828e-06 3.02994609716876e-06 220 397.363636363636 323 1.0329367029683e-07 105 1.82853335738461 2.16719318992306 1 13.4311083097921 541 217 220 105 323 797 800 294 147 366 561 286 M18091 GO_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. 283/710 Gene Ontology MF GO:0004672 9.22763792108398e-09 1.60588455503452e-07 325 334.545454545455 324 8.38876178162563e-10 20 1.48809418965039 1.71239792395974 1 13.4572716329223 324 64 319 282 20 779 424 361 369 304 434 287 M18163 GO_METALLOEXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOEXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 17/53 Gene Ontology MF GO:0008235 1.87945997303648e-06 4.62327052190792e-06 200 336.363636363636 325 1.70860143514639e-07 198 1.7285404957582 2.40933421618973 1 12.2744177295432 200 367 241 504 348 447 325 198 303 496 271 288 M18100 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS.html Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). 87/208 Gene Ontology MF GO:0016758 1.09323312564065e-08 1.70470250099898e-07 360 348 327 9.93848300975623e-10 27 1.47307485330781 -0.991311093947843 -1 13.2705984358416 360 240 277 327 27 897 495 91 220 489 405 289 M18412 GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. 32/83 Gene Ontology MF GO:0042625 3.39902698915182e-06 7.79826640902662e-06 540 312.636363636364 327 3.0900293097287e-07 42 1.54321897637234 -1.51012110297867 -1 10.4920751145639 537 161 281 42 375 270 566 202 337 341 327 290 M18754 GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 4/21 Gene Ontology MF GO:0005248 6.64382656893222e-07 1.99098385779076e-06 355 297.181818181818 327 6.64382855525247e-08 53 2.00945898796139 2.52297111528353 1 15.247822445083 353 130 809 108 327 528 331 53 84 337 209 291 M18776 GO_NEUREXIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUREXIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. 9/14 Gene Ontology MF GO:0042043 7.74898156094783e-05 0.000133253514692935 295 366.727272727273 331 7.7492517844282e-06 114 1.43327174763813 -1.51129377152568 -1 7.39297131773664 295 379 816 520 501 141 114 331 660 151 126 292 M18032 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 73/223 Gene Ontology MF GO:0001227 9.86666945831746e-07 2.76748045782075e-06 335 323.727272727273 332 8.96970353033931e-08 180 1.60587121238106 1.78652930353852 1 11.8796989891978 180 315 206 531 306 370 332 341 334 233 413 293 M18697 GO_CHEMOATTRACTANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOATTRACTANT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. 14/29 Gene Ontology MF GO:0042056 2.26610736375881e-05 4.2117551003194e-05 315 415.181818181818 336 2.06011882373379e-06 222 2.05744275197397 2.26243711431504 1 11.9823471816592 315 727 222 637 460 336 281 523 485 303 278 294 M18551 GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. 9/22 Gene Ontology MF GO:0004653 1.36351630609962e-06 3.55364023119447e-06 260 513.454545454545 337 1.36351714272986e-07 228 1.39803860833925 -1.3539102598645 -1 10.1401593453216 834 261 768 257 335 827 676 337 228 258 867 295 M18725 GO_CCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a CCR chemokine receptor. 12/50 Gene Ontology MF GO:0048020 6.47368919621499e-07 1.95271936410419e-06 340 374.727272727273 337 5.88517372832227e-08 179 1.74251463181025 2.24170506385753 1 13.2417891313131 337 500 179 414 285 598 334 240 504 248 483 296 M18285 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 232/695 Gene Ontology MF GO:0000981 4.41033857029183e-08 2.87766771962304e-07 225 299.818181818182 338 4.00939878064169e-09 63 1.5990442495943 1.69030602422068 1 13.9214581993533 221 153 77 384 110 495 338 478 373 63 606 297 M18388 GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 93/261 Gene Ontology MF GO:0005088 1.81864623641032e-07 7.2430932359199e-07 340 402.363636363636 338 1.65331489704552e-08 134 1.46425792963581 1.49259695208777 1 11.9666920555492 338 134 190 289 207 743 473 690 426 157 779 298 M19126 GO_OPSONIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPSONIN_BINDING.html Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. 5/21 Gene Ontology MF GO:0001846 9.9752136650479e-07 2.77539490971844e-06 345 360 338 9.97521814277067e-08 164 1.49191799038219 1.68803807918053 1 11.0342482263051 341 290 900 338 318 440 344 164 260 223 342 299 M17863 GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate from one side of the membrane to the other. 15/38 Gene Ontology MF GO:1901677 1.62133775466284e-06 4.09788663266432e-06 500 368.272727272727 340 1.47394449958557e-07 76 1.16048044746348 1.2397155407699 1 8.32152743460811 497 76 342 207 340 654 447 308 232 323 625 300 M18376 GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS.html Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). 12/20 Gene Ontology MF GO:0016780 8.25092936887597e-07 2.39459148875896e-06 340 345.818181818182 340 7.5008476939315e-08 56 1.4762394523381 -1.4762394523381 -1 11.0442263006141 340 511 413 549 491 173 305 56 257 617 92 301 M17918 GO_LIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of lipids into, out of or within a cell, or between cells. 49/169 Gene Ontology MF GO:0005319 1.02369444818245e-06 2.81975716265824e-06 235 482.454545454545 341 9.30631749567103e-08 102 2.09516811102794 -1.70678774640046 -1 15.4766902520495 870 341 102 232 309 516 889 701 267 235 845 302 M18469 GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). 4/12 Gene Ontology MF GO:0008556 4.99551424726246e-05 8.73740134502179e-05 780 464.727272727273 341 4.99562654904718e-06 123 2.19375546547586 -3.29506164215868 -1 11.8508404527899 778 327 747 123 555 723 341 141 161 335 881 303 M18816 GO_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a growth factor receptor. 75/186 Gene Ontology MF GO:0070851 1.12688033933764e-07 5.15786025965486e-07 280 410.909090909091 342 1.02443672459865e-08 172 1.57845019512906 1.41976848570763 1 13.2097249912981 278 268 250 639 172 452 295 665 524 342 635 304 M19110 GO_NUCLEOTIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. 11/28 Gene Ontology MF GO:0019201 1.75274722786387e-06 4.39380776467238e-06 190 392.909090909091 343 1.59340784025901e-07 114 0.74359719293654 -0.74359719293654 -1 5.30218661436536 190 582 477 563 343 114 135 260 810 725 123 305 M18853 GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). 4/18 Gene Ontology MF GO:0016775 9.76490267852172e-05 0.000165267072140322 450 448 344 9.76533179501983e-06 171 1.65202361824647 -2.60159229205022 -1 8.31570643544273 447 344 829 316 513 263 330 859 171 566 290 306 M19165 GO_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_ACTIVITY.html Catalysis of the hydrolysis of a glycerophospholipid. 31/102 Gene Ontology MF GO:0004620 1.0434426805552e-06 2.84722895232974e-06 345 361.909090909091 344 9.4858470495653e-08 157 1.83021660119162 2.12631018972267 1 13.5092759207381 344 382 157 555 312 479 207 544 320 192 489 307 M19029 GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 117/338 Gene Ontology MF GO:0003714 3.59114902950175e-08 2.5220283260623e-07 345 350.909090909091 345 3.2646809892014e-09 101 1.42570318845025 1.4920238256204 1 12.5210480191607 280 345 349 533 101 436 237 458 341 320 460 308 M18464 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). 99/229 Gene Ontology MF GO:0016747 6.6424429059692e-07 1.99098385779076e-06 165 359.272727272727 346 6.03858628319788e-08 18 1.06139055756453 -0.981562827697151 -1 8.05385615680867 161 346 574 802 363 18 129 203 517 763 76 309 M19200 GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a calcium channel. 18/62 Gene Ontology MF GO:0005246 6.75897381388172e-07 2.01238055300038e-06 290 336.636363636364 346 6.1445235367415e-08 140 1.68467418737418 1.88714250361402 1 12.7729377724372 354 216 174 346 288 498 361 440 290 140 596 310 M18351 GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. 17/37 Gene Ontology MF GO:0051119 1.86656906859304e-06 4.60387008875495e-06 195 429.272727272727 347 1.69688241115244e-07 75 1.52597813686249 1.7788210563729 1 10.8397255115639 750 75 195 159 347 702 762 465 197 193 877 311 M18407 GO_FIBROBLAST_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with a fibroblast growth factor. 14/55 Gene Ontology MF GO:0017134 1.35136005561613e-05 2.65300000568127e-05 120 338.181818181818 347 1.22851668770766e-06 108 2.386494095359 2.386494095359 1 14.5363078823751 179 652 347 374 663 262 119 108 360 537 119 312 M19172 GO_MACROMOLECULAR_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_BINDING.html Interacting selectively and non-covalently with any macromolecular complex. 776/1921 Gene Ontology MF GO:0044877 5.78531448779968e-08 3.34747756526774e-07 205 386.090909090909 347 5.78531463841407e-09 88 1.74084531669729 2.08508927812406 1 15.0038146359817 205 495 905 417 134 748 307 226 347 88 375 313 M17959 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. 57/142 Gene Ontology MF GO:0016616 2.23772640568166e-07 8.51496019772218e-07 645 399 348 2.03429693935606e-08 186 1.48092544320132 -1.33806956314122 -1 11.9644188549201 644 280 348 574 220 222 730 394 530 186 261 314 M18065 GO_PEPTIDE_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for peptide hormones. 8/24 Gene Ontology MF GO:0051428 1.43490090655e-07 6.14004108849304e-07 495 361.454545454545 348 1.43490099920234e-08 11 2.02409157838243 2.34022810228307 1 16.7352587666317 494 234 658 11 196 621 564 155 49 348 646 315 M18845 GO_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. 45/104 Gene Ontology MF GO:0008238 6.78831682391126e-08 3.67367733999904e-07 230 326.818181818182 348 6.17119730306498e-09 140 1.63957221009808 2.20216023402042 1 14.0428442274266 228 348 305 556 140 453 224 152 392 417 380 316 M18842 GO_MYOSIN_V_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_V_BINDING.html Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. 9/22 Gene Ontology MF GO:0031489 1.458840636176e-06 3.73853310663488e-06 650 388.090909090909 349 1.45884159387408e-07 126 1.56173399458963 -1.45818822868663 -1 11.2816748903232 646 260 827 131 339 349 627 217 126 395 352 317 M18446 GO_LIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 8/19 Gene Ontology MF GO:0055102 4.74233775736179e-07 1.49416121122358e-06 350 369.909090909091 350 4.74233876940162e-08 130 1.56135811253958 1.6608142852904 1 12.1067107079056 347 380 742 649 273 425 165 257 351 350 130 318 M18529 GO_WW_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WW_DOMAIN_BINDING.html Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. 16/34 Gene Ontology MF GO:0050699 2.02327464860783e-06 4.89845441241897e-06 760 468.090909090909 350 1.83934228123257e-07 49 2.15983502566616 -1.42392093499567 -1 15.2648685255733 758 49 133 195 350 796 843 902 59 261 803 319 M19081 GO_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 331/838 Gene Ontology MF GO:0016491 2.27786295744181e-08 1.97762447895865e-07 410 326.545454545455 350 2.07078452820602e-09 57 1.43114372385856 -1.19941052630554 -1 12.7699950935789 350 409 332 611 73 57 407 408 467 284 194 320 M19210 GO_HEXOSAMINIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSAMINIDASE_ACTIVITY.html Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. 9/18 Gene Ontology MF GO:0015929 1.9170297418318e-06 4.70311296662734e-06 520 427.454545454545 352 1.91703139558517e-07 111 1.44352215016267 -0.768374613207397 -1 10.2362063897057 520 231 917 280 352 840 538 111 215 399 299 321 M18674 GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate into, out of or within a cell, or between cells. 23/47 Gene Ontology MF GO:1901476 2.130171488221e-06 5.13025594021812e-06 175 423.363636363636 353 1.93652140980286e-07 20 1.89973647252707 2.10367969303686 1 13.3758198915363 720 20 75 174 353 780 669 516 306 172 872 322 M18298 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 76/168 Gene Ontology MF GO:0001076 1.79910231073925e-08 1.87474234565248e-07 535 421.090909090909 355 1.63554756859258e-09 9 1.40684002615099 1.45008197572411 1 12.5965816498618 535 9 327 330 54 825 611 531 355 306 749 323 M19038 GO_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. 165/602 Gene Ontology MF GO:0004175 2.31730690102972e-08 1.99245079340873e-07 700 423.636363636364 356 2.10664265948945e-09 76 1.78769342078492 -1.61971135720675 -1 15.943744943805 698 356 121 834 76 93 735 903 407 109 328 324 M18907 GO_PDZ_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PDZ_DOMAIN_BINDING.html Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. 53/141 Gene Ontology MF GO:0030165 2.98462766019386e-07 1.04803719365586e-06 240 394.545454545455 358 2.71329824100285e-08 185 1.38282207357682 1.61340744160975 1 11.0058329015149 358 401 236 312 240 768 428 670 313 185 429 325 M17878 GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. 14/37 Gene Ontology MF GO:0008376 2.99811743241252e-08 2.2707385136175e-07 360 356.727272727273 359 2.72556133933663e-09 91 1.30549884755017 1.26919028831442 1 11.5445758023136 396 351 359 378 91 536 356 252 385 300 520 326 M18571 GO_FERROUS_IRON_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERROUS_IRON_BINDING.html Interacting selectively and non-covalently with ferrous iron, Fe(II). 15/29 Gene Ontology MF GO:0008198 2.10196509611314e-07 8.2641362753166e-07 455 391.545454545455 359 1.91087754267549e-08 68 1.9636579586383 1.93347532528593 1 15.8983612102583 454 553 254 199 214 727 359 702 68 455 322 327 M18584 GO_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 18/36 Gene Ontology MF GO:0008378 2.00623090638965e-06 4.87000642184295e-06 725 479.818181818182 359 1.82384794174579e-07 170 2.04212040475764 -1.31129245203497 -1 14.4397831119617 725 651 170 250 349 821 664 234 359 305 750 328 M18362 GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. 12/29 Gene Ontology MF GO:0008106 2.33895129113894e-07 8.78300076672582e-07 810 485.181818181818 360 2.12631958164259e-08 189 1.86541180194501 -1.82501233422786 -1 15.0372697727042 809 189 312 320 223 711 861 622 346 360 584 329 M18867 GO_NF_KAPPAB_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NF_KAPPAB_BINDING.html Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. 19/42 Gene Ontology MF GO:0051059 1.67353508660047e-05 3.22102987379171e-05 340 355.181818181818 360 1.52140710661825e-06 54 0.928782659631237 -0.733500564786782 -1 5.55312044156381 339 450 474 360 490 54 284 175 562 646 73 330 M18429 GO_RAB_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GTPASE_BINDING.html Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. 66/135 Gene Ontology MF GO:0017137 7.99438946700352e-08 4.13193163463104e-07 770 445.090909090909 362 7.26762705227701e-09 69 1.24808939795671 -1.19272427920846 -1 10.6050064983025 768 69 362 238 149 424 891 767 329 340 559 331 M18648 GO_CARBON_SULFUR_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_SULFUR_LYASE_ACTIVITY.html Catalysis of the elimination of hydrogen sulfide or substituted H2S. 8/13 Gene Ontology MF GO:0016846 4.03387741989026e-06 8.98587706125675e-06 305 431.363636363636 362 4.03388474238413e-07 87 1.36802412164925 -1.36802412164925 -1 9.18885936597468 303 575 790 357 577 265 362 87 740 520 169 332 M18738 GO_TASTE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TASTE_RECEPTOR_ACTIVITY.html Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. 2/40 Gene Ontology MF GO:0008527 1.25125117946344e-08 1.7710016693944e-07 475 320.9 362.5 1.39027909602421e-09 5 1.82624305551106 -0.9824347333171 -1 16.4119327014182 475 83 804 NA 424 559 301 8 5 453 97 333 M19149 GO_MONOCARBOXYLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BINDING.html Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). 32/99 Gene Ontology MF GO:0033293 0.000132145364484467 0.000218657797348399 255 356.636363636364 364 1.20139366004868e-05 112 2.20036910842926 2.3651443996044 1 10.7198151518067 254 476 112 258 518 422 293 486 457 283 364 334 M18687 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. 19/37 Gene Ontology MF GO:0032266 8.68209907990129e-06 1.7593680954866e-05 285 435.909090909091 365 7.89284849381972e-07 99 1.84246292630608 2.43625183143821 1 11.6600251176459 282 869 355 593 519 547 365 99 244 645 277 335 M18993 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the tumor necrosis factor receptor. 12/34 Gene Ontology MF GO:0005164 2.29608139670451e-05 4.25886065517772e-05 570 372 365 2.08736850967688e-06 205 1.53245022413228 -1.14443654716337 -1 8.91498880840222 567 321 259 307 462 247 471 205 381 365 507 336 M18373 GO_AMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BINDING.html Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. 4/11 Gene Ontology MF GO:0043176 1.70086672010165e-05 3.26680038098856e-05 370 380.090909090909 367 1.70087973850609e-06 97 2.54653639912777 3.31736503398603 1 15.2047781178495 367 302 726 221 454 546 543 288 97 164 473 337 M18790 GO_SIALYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. 6/21 Gene Ontology MF GO:0008373 0.000660558935391131 0.000975464238458813 220 431.272727272727 368 6.60755369723402e-05 96 1.72681391821115 1.72681391821115 1 6.9200394155927 217 546 818 408 787 324 96 348 368 628 204 338 M18209 GO_GLUTATHIONE_PEROXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_PEROXIDASE_ACTIVITY.html Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. 11/17 Gene Ontology MF GO:0004602 8.16817806451823e-05 0.000139938991049474 345 405.181818181818 369 7.42589213551705e-06 211 1.60774736787285 -1.35081165383774 -1 8.24744049372628 343 369 278 463 499 211 303 584 487 601 319 339 M18518 GO_CHANNEL_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_INHIBITOR_ACTIVITY.html Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 23/62 Gene Ontology MF GO:0016248 5.9811689588301e-07 1.82207796096811e-06 300 413.454545454545 370 5.43742780449e-08 214 1.25339198926908 1.44687148018503 1 9.57499789275955 298 214 370 227 282 531 458 901 479 326 462 340 M18637 GO_ISOPRENOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BINDING.html Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 7/53 Gene Ontology MF GO:0019840 1.92851128434997e-05 3.65067979753493e-05 115 357.181818181818 370 1.92852802075538e-06 73 4.39353459956901 4.39353459956901 1 25.9506108979329 234 562 786 111 520 580 370 113 73 479 101 341 M18688 GO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 95/190 Gene Ontology MF GO:0016829 1.22709309748715e-07 5.45374709994287e-07 510 434.909090909091 371 1.11553924175516e-08 178 1.16882438663649 -1.05136975488666 -1 9.74396252044203 509 465 371 720 178 229 667 332 664 369 280 342 M18409 GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. 7/15 Gene Ontology MF GO:0048531 1.44922176693169e-05 2.83075164666063e-05 370 394.727272727273 372 1.44923121811522e-06 271 1.52270921275186 -1.4858384774365 -1 9.2178489652699 366 413 734 432 445 271 372 420 294 308 287 343 M18706 GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a substance from one side of a membrane to the other. 347/1090 Gene Ontology MF GO:0022857 1.07589861055294e-07 5.0245011254249e-07 640 375.090909090909 372 9.78089693790188e-09 20 1.61651273868073 1.83815594998909 1 13.5527405854528 636 112 36 185 168 489 670 562 372 20 876 344 M18497 GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 38/96 Gene Ontology MF GO:0004702 2.07825064861246e-06 5.01834802289622e-06 880 442.363636363636 373 1.88932055623094e-07 18 1.25101202772757 -1.33289871029311 -1 8.82417627131498 876 18 345 240 351 681 602 758 427 373 195 345 M19153 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the platelet-derived growth factor receptor. 9/18 Gene Ontology MF GO:0005161 4.15775492235008e-07 1.35643068388726e-06 85 334.090909090909 373 4.15775570026195e-08 46 2.17672961532179 2.17672961532179 1 16.9999625721027 83 469 901 373 639 102 59 46 511 398 94 346 M18955 GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. 8/19 Gene Ontology MF GO:0015166 0.000791059412621448 0.00115260149818497 150 419.454545454545 375 7.91341152532028e-05 148 2.93375989693895 2.62568548780399 1 11.4737812984812 375 148 861 148 579 437 179 848 287 355 397 347 M17887 GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. 4/16 Gene Ontology MF GO:0004115 0.00138512920909154 0.00193960254545542 310 451.818181818182 376 0.000138599332955288 123 1.63880679982834 1.63880679982834 1 5.9162454801736 307 674 615 661 650 300 123 360 575 329 376 348 M18291 GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS.html Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 18/40 Gene Ontology MF GO:0016877 8.14555047725941e-06 1.67274697300863e-05 195 352.181818181818 376 7.40507330591207e-07 60 1.15258430720803 -1.29159051294181 -1 7.3277659244582 192 376 471 660 417 60 62 228 519 764 125 349 M19156 GO_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. 469/1395 Gene Ontology MF GO:0005215 7.02476790647366e-08 3.73107484368215e-07 840 413.272727272727 376 6.38615284616352e-09 55 1.56141672973941 -1.33332638978095 -1 13.3594539742262 838 314 70 376 143 230 856 519 459 55 686 350 M18111 GO_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with an identical protein to form a homodimer. 398/1017 Gene Ontology MF GO:0042803 2.79296322934428e-08 2.15926568991322e-07 90 364.090909090909 377 2.53905751345613e-09 56 1.65207296027424 -1.44353844254004 -1 14.6574151083501 498 176 56 230 89 630 509 636 377 90 714 351 M18368 GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a protein serine/threonine kinase. 19/35 Gene Ontology MF GO:0030291 3.5808616868032e-06 8.13430309100973e-06 595 451.272727272727 377 3.25533410477961e-07 238 1.54602163051763 1.39959261966302 1 10.4734266906876 592 366 260 348 377 794 477 418 281 238 813 352 M18471 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. 11/22 Gene Ontology MF GO:0016722 1.19695879819627e-06 3.16437383431198e-06 355 377.090909090909 378 1.08814495402614e-07 237 1.37184825292538 -1.37184825292538 -1 10.0421989289961 355 378 384 449 326 302 402 483 237 460 372 353 M18918 GO_SIGNALING_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. 35/96 Gene Ontology MF GO:0035591 5.0176039490798e-06 1.08107626069167e-05 315 380.272727272727 378 4.56146853901047e-07 212 1.45958180866109 -1.07792372829276 -1 9.64784905891405 313 578 363 340 394 494 302 212 401 408 378 354 M18926 GO_INORGANIC_ANION_EXCHANGER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_EXCHANGER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). 3/24 Gene Ontology MF GO:0005452 0.0385925583999434 0.0452871858774846 265 429.909090909091 378 0.00392796360722239 210 1.62266623592602 1.62266623592602 1 2.90281322679545 264 265 853 276 691 435 378 577 210 277 503 355 M18109 GO_LIGAND_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 39/161 Gene Ontology MF GO:0022834 6.74298617323106e-08 3.6707380351317e-07 835 434.363636363636 380 6.12998761809378e-09 72 1.64627316919865 -1.64305748358329 -1 14.1009992763805 831 226 118 182 139 770 657 641 380 72 762 356 M18253 GO_CAMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BINDING.html Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). 6/29 Gene Ontology MF GO:0030552 0.000270386474741652 0.000426681915544288 230 401.090909090909 380 2.7041937935711e-05 226 1.36036572466762 1.36036572466762 1 6.10175683941597 226 407 699 380 547 330 234 303 382 623 281 357 M18552 GO_MODIFIED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a modified amino acid. 45/101 Gene Ontology MF GO:0072341 3.80821253861895e-06 8.5661504536172e-06 290 404.909090909091 380 3.46201739152049e-07 202 1.9324942231206 2.06375432093611 1 13.0337764818622 289 721 202 456 380 470 320 280 580 345 411 358 M18516 GO_HMG_BOX_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HMG_BOX_DOMAIN_BINDING.html Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. 9/22 Gene Ontology MF GO:0071837 4.18785681026507e-05 7.42356120509416e-05 485 380.818181818182 383 4.18793573400936e-06 61 2.0360596703109 2.53943764878201 1 11.1907436780144 373 312 759 93 483 482 515 383 61 149 579 359 M18923 GO_DOPAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_BINDING.html Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. 3/12 Gene Ontology MF GO:0035240 2.24613169087962e-06 5.35536852946221e-06 290 369.454545454545 384 2.24613396118126e-07 75 1.94080343163943 1.94080343163943 1 13.6167892831029 288 419 851 415 572 384 200 75 180 505 175 360 M18019 GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 12/21 Gene Ontology MF GO:0030676 2.14570745443831e-06 5.15417978611813e-06 495 442.909090909091 386 1.95064504290539e-07 244 1.32699850994469 1.17404207509162 1 9.33967048322025 493 334 338 421 355 577 386 594 358 244 772 361 M18586 GO_ALKALI_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALI_METAL_ION_BINDING.html Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. 14/43 Gene Ontology MF GO:0031420 2.24692636127436e-06 5.35536852946221e-06 600 432.545454545455 386 2.04266241466483e-07 271 1.80429787442846 -1.98322206354406 -1 12.6590583042037 507 599 294 326 358 375 596 271 632 414 386 362 M18950 GO_ACTIN_MONOMER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MONOMER_BINDING.html Interacting selectively and non-covalently with monomeric actin, also known as G-actin. 18/36 Gene Ontology MF GO:0003785 1.2399827935082e-06 3.25938334293585e-06 485 415.545454545455 386 1.12725772036223e-07 228 1.47497634442069 -1.3827669523659 -1 10.7718942094686 485 287 314 291 330 599 228 661 386 527 463 363 M18202 GO_AMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. 24/43 Gene Ontology MF GO:0004177 3.32937527797639e-08 2.41183091003014e-07 220 388.818181818182 387 3.02670484396507e-09 95 1.37597333000025 1.74636111005231 1 12.1198377634186 220 319 346 676 95 463 268 450 597 456 387 364 M18473 GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. 9/55 Gene Ontology MF GO:0005231 2.79027281787797e-05 5.11364739531421e-05 240 382 387 2.79030785379791e-06 148 1.87296376160325 1.96172758097122 1 10.6978848902344 238 415 748 543 468 387 199 409 282 148 365 365 M18875 GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. 6/13 Gene Ontology MF GO:0008484 4.04427610291636e-06 8.98728022870303e-06 560 490.363636363636 387 4.04428346321135e-07 21 1.66018285552567 2.25235596205461 1 11.1511061074972 556 353 836 222 387 890 794 382 21 630 323 366 M19192 GO_ARMADILLO_REPEAT_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARMADILLO_REPEAT_DOMAIN_BINDING.html Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. 5/19 Gene Ontology MF GO:0070016 0.000363939487995555 0.000558972168540752 175 422.727272727273 387 3.63999105115377e-05 81 1.89816049874943 1.89816049874943 1 8.21765054952173 174 613 912 507 782 127 81 231 647 387 189 367 M18710 GO_KINESIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_BINDING.html Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. 24/60 Gene Ontology MF GO:0019894 1.20020843953921e-07 5.38630128963938e-07 460 375.818181818182 388 1.09109864092409e-08 137 2.28339021947743 -1.52646388345351 -1 19.0520220924194 470 460 137 388 176 537 364 354 317 457 474 368 M18736 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 52/149 Gene Ontology MF GO:0001078 5.386726614117e-07 1.66301627013008e-06 400 429.181818181818 388 4.89702539369452e-08 198 1.43537594940475 1.55364474098173 1 11.0410130540499 399 198 283 379 275 698 415 714 388 279 693 369 M18477 GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 21/44 Gene Ontology MF GO:0046915 4.44738247390682e-06 9.76263956916305e-06 665 485.818181818182 389 4.04308314952968e-07 350 1.38552420940457 -1.22834354017943 -1 9.24000342360692 539 663 350 662 386 351 665 389 583 375 381 370 M18235 GO_ANTIOXIDANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIOXIDANT_ACTIVITY.html Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. 31/82 Gene Ontology MF GO:0016209 9.34781310787227e-08 4.64864219418513e-07 375 389 390 8.49801227732859e-09 155 1.70958746529042 -1.43117581138195 -1 14.4099092188248 371 390 173 451 155 266 579 652 481 319 442 371 M19188 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING.html Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. 26/57 Gene Ontology MF GO:0032813 5.68723700085594e-06 1.21398098394141e-05 390 351.818181818182 390 5.17022882093588e-07 149 1.24257234077575 -1.09472636301535 -1 8.1301321801351 477 269 333 389 399 149 396 390 451 405 212 372 M17855 GO_BETA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_BINDING.html Interacting selectively and non-covalently with the beta subunit of the catenin complex. 43/129 Gene Ontology MF GO:0008013 4.60901709824821e-07 1.47232490638484e-06 395 460.545454545455 391 4.19001642167377e-08 201 1.82547100660176 2.46510767080629 1 14.1701673199124 654 358 201 391 265 720 812 335 263 391 676 373 M18021 GO_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 39/105 Gene Ontology MF GO:0019210 1.47580656817358e-06 3.76105829008224e-06 350 427.272727272727 392 1.34164323470617e-07 307 1.42829098337705 1.52565258507134 1 10.3127477910374 392 528 307 519 334 635 346 347 367 400 525 374 M19035 GO_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glutamate receptor. 21/50 Gene Ontology MF GO:0035254 6.01246884321384e-06 1.27160260592109e-05 610 407.727272727273 392 5.46589570454147e-07 142 1.62229555845984 -1.74596399331248 -1 10.5711685982337 607 497 300 325 404 392 775 142 269 587 187 375 M18522 GO_MANNOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 12/22 Gene Ontology MF GO:0000030 1.89873581395859e-05 3.60172566771527e-05 140 373.636363636364 393 1.72613836492621e-06 72 0.70710918976526 -0.70710918976526 -1 4.18208962773586 137 393 513 594 455 72 94 161 628 871 192 376 M18671 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. 9/29 Gene Ontology MF GO:0016701 4.19823642405546e-06 9.28456132243035e-06 535 379.363636363636 393 4.19824435541164e-07 86 2.49241938148706 -2.82011823737351 -1 16.6941821143231 533 262 795 419 390 428 456 168 243 86 393 377 M18911 GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. 10/74 Gene Ontology MF GO:0005230 2.77755571417184e-05 5.10050151105407e-05 385 396.454545454545 394 2.52508252921452e-06 105 1.84782234876239 1.96172758097122 1 10.5570330687384 382 394 198 464 466 581 366 619 292 105 494 378 M18797 GO_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. 291/803 Gene Ontology MF GO:0008134 2.25775683878352e-08 1.97762447895865e-07 400 379.818181818182 396 2.05250623813984e-09 71 1.47997262142242 1.76462486190159 1 13.205691963041 398 177 296 452 71 864 438 396 343 197 546 379 M18392 GO_ENZYME_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of an enzyme. 250/550 Gene Ontology MF GO:0008047 3.48110734180913e-09 9.35826345819752e-08 670 441.818181818182 397 3.16464304301577e-10 2 1.51793528346346 -1.21227731307374 -1 14.20095431763 670 85 219 397 2 678 689 633 332 240 915 380 M18492 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein receptor. 8/20 Gene Ontology MF GO:0050750 1.50029215087965e-06 3.81289717903116e-06 305 452.090909090909 397 1.50029316377506e-07 70 2.23557427096961 2.23557427096961 1 16.1239190694724 305 699 753 553 790 397 196 70 229 676 305 381 M18959 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. 44/103 Gene Ontology MF GO:0016811 5.50502642013818e-06 1.18056510641658e-05 285 330.727272727273 397 5.00458199575456e-07 90 1.12444626885787 -1.06848120797882 -1 7.37537730845871 281 138 427 439 397 90 299 466 413 485 203 382 M18915 GO_IRON_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_BINDING.html Interacting selectively and non-covalently with iron (Fe) ions. 55/229 Gene Ontology MF GO:0005506 8.94322767872946e-07 2.54729704781149e-06 620 435.727272727273 398 8.13021028567832e-08 82 1.67809477755466 1.89153244147735 1 12.4944044363704 372 364 149 398 300 792 618 682 418 82 618 383 M17999 GO_ACID_AMINO_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_AMINO_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 13/27 Gene Ontology MF GO:0016881 0.000539803170974445 0.000808825598202752 215 435.272727272727 400 4.90850604851784e-05 149 0.993395468809149 -0.958764079783972 -1 4.08850702129119 214 499 400 791 673 161 149 214 785 637 265 384 M17974 GO_PROTEIN_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any protein phosphatase. 79/199 Gene Ontology MF GO:0019903 1.5333435013606e-07 6.44144301941438e-07 550 446.363636363636 402 1.39394873475519e-08 194 1.78158816915346 2.29533843967367 1 14.6808804443541 546 475 237 218 194 814 572 346 376 402 730 385 M18668 GO_RRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_BINDING.html Interacting selectively and non-covalently with ribosomal RNA. 42/89 Gene Ontology MF GO:0019843 0.00156609641187504 0.00216013298189661 370 480.363636363636 402 0.000142473851703284 251 1.4427030964291 -1.43716232955695 -1 5.11848649275062 369 689 569 654 601 251 384 287 312 766 402 386 M18681 GO_GLUTATHIONE_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_TRANSFERASE_ACTIVITY.html Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. 16/38 Gene Ontology MF GO:0004364 2.07388704176692e-05 3.88589832673231e-05 195 389.363636363636 404 1.88536962914441e-06 125 1.19975751341382 -1.19808405150195 -1 7.04311707402871 194 404 330 505 456 125 291 617 666 468 227 387 M19160 GO_EXODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. 7/19 Gene Ontology MF GO:0004529 0.00108927476218302 0.00155852687590727 250 459.272727272727 405 0.000108980906459958 159 1.15676030647283 -1.15676030647283 -1 4.32227808446051 249 611 903 405 694 159 202 386 528 665 250 388 M18777 GO_MICROTUBULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BINDING.html Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. 102/252 Gene Ontology MF GO:0008017 4.72523024352552e-08 2.97592386690275e-07 360 483.090909090909 406 4.2956639500141e-09 112 1.58090000417421 1.95536180501325 1 13.7328106385268 359 823 324 625 112 833 451 401 390 406 590 389 M18402 GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 21/46 Gene Ontology MF GO:0008138 9.89643380008426e-08 4.79195741898817e-07 560 503.181818181818 409 8.99675840478492e-09 161 1.22043805476674 1.09828051503743 1 10.2655057680654 559 285 356 409 161 765 379 843 516 374 888 390 M18447 GO_CHROMATIN_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DNA_BINDING.html Interacting selectively and non-covalently with DNA that is assembled into chromatin. 53/136 Gene Ontology MF GO:0031490 4.78958737665197e-05 8.42527798569754e-05 595 445.363636363636 411 4.35426513929708e-06 136 1.9093987016595 -1.57794448365196 -1 10.354872329754 593 734 310 344 484 136 549 762 363 411 213 391 M18135 GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. 18/45 Gene Ontology MF GO:0015662 7.31397521445253e-06 1.51892938990888e-05 630 385.818181818182 412 6.64909048193305e-07 41 1.68466399129741 1.59286578646285 1 10.8044970069266 626 47 162 41 412 766 559 456 325 138 712 392 M18268 GO_ALCOHOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BINDING.html Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. 40/136 Gene Ontology MF GO:0043178 4.75500878733374e-08 2.97592386690275e-07 670 430.727272727273 412 4.32273535464269e-09 115 1.34971054017895 -1.27442844906228 -1 11.7245359870499 668 181 214 333 115 501 815 727 412 209 563 393 M18384 GO_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any phosphatase. 97/251 Gene Ontology MF GO:0019902 1.43355403264934e-06 3.69431291327001e-06 625 461.363636363636 412 1.30323178797834e-07 210 1.78714926982192 2.33148570904742 1 12.9223251086268 623 456 244 210 332 637 668 412 348 403 742 394 M18535 GO_LIGASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_REGULATOR_ACTIVITY.html Modulates the activity of a ligase. 8/20 Gene Ontology MF GO:0055103 3.33002108971613e-05 6.03074685539142e-05 150 364.181818181818 412 3.33007099145062e-06 73 1.22638453765965 -1.22638453765965 -1 6.88785002070855 146 412 765 437 575 73 101 282 600 517 98 395 M19190 GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. 64/150 Gene Ontology MF GO:0001046 7.25919548929227e-06 1.51096376700201e-05 415 471.545454545455 413 6.59929040190313e-07 214 1.62986456062177 -1.23442602396192 -1 10.457997767459 841 426 245 262 411 413 898 754 309 214 414 396 M19225 GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a nucleotidyl group to a reactant. 69/136 Gene Ontology MF GO:0016779 2.81910348802721e-06 6.56601318730389e-06 210 517.545454545455 413 2.56282463678455e-07 209 1.05774801851193 -0.990481597046933 -1 7.29660616727674 209 856 589 854 366 250 413 353 676 729 398 397 M19052 GO_GAP_JUNCTION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION_CHANNEL_ACTIVITY.html A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. 9/19 Gene Ontology MF GO:0005243 7.20276875759367e-05 0.000124092645261913 140 407.818181818182 414 7.20300222769405e-06 138 2.18707272347018 2.24069269402187 1 11.3712049179434 138 474 879 431 498 298 172 414 681 152 349 398 M18196 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 11/29 Gene Ontology MF GO:0008519 7.66210202462278e-06 1.58407502531527e-05 405 420.363636363636 415 6.96557155465446e-07 106 1.57090765484781 -1.83588262397395 -1 10.0367929200033 404 522 253 492 415 455 697 106 383 600 297 399 M17897 GO_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. 52/152 Gene Ontology MF GO:0016597 6.70794735412332e-06 1.40576573252698e-05 575 458.090909090909 419 6.09815255199219e-07 106 2.24762958987721 -1.86125951815963 -1 14.5156377453412 573 638 106 152 408 847 541 362 419 321 672 400 M18094 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the epidermal growth factor receptor. 22/47 Gene Ontology MF GO:0005154 8.6275243513267e-06 1.75604477947358e-05 795 522.545454545455 420 7.84323471384456e-07 275 1.72793969513531 1.09978949248662 1 10.9371533875009 791 375 275 309 420 883 506 813 296 409 671 401 M18182 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS.html Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. 19/47 Gene Ontology MF GO:0016706 0.00277340636639173 0.00371943710944663 805 472.909090909091 420 0.000252446255849782 193 1.71195437615873 1.98466935543715 1 5.53599770348457 438 803 420 425 801 721 406 402 193 327 266 402 M18981 GO_LIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BINDING.html Interacting selectively and non-covalently with a lipid. 309/886 Gene Ontology MF GO:0008289 6.97105735070479e-09 1.4251939472552e-07 685 427.181818181818 420 6.33732488435792e-10 10 1.59328676675184 -1.31613919009506 -1 14.5184962162458 682 208 76 284 10 659 678 755 420 64 863 403 M18661 GO_MAP_KINASE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. 10/14 Gene Ontology MF GO:0033549 2.09937354778152e-08 1.97084047342755e-07 570 466.454545454545 421 1.90852142528637e-09 65 1.36199624118987 0.95296366180351 1 12.1557022965131 569 335 285 319 65 567 326 884 514 421 846 404 M18011 GO_DIACYLGLYCEROL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_KINASE_ACTIVITY.html Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. 5/11 Gene Ontology MF GO:0004143 7.87596947597245e-06 1.62463944347414e-05 725 419.545454545455 422 7.87599739001451e-07 61 1.45938302033127 -1.81274589030084 -1 9.30291257663626 722 61 637 166 422 563 677 374 71 381 541 405 M18423 GO_14_3_3_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_14_3_3_PROTEIN_BINDING.html Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. 17/67 Gene Ontology MF GO:0071889 1.70658392100201e-05 3.27095251525385e-05 320 392.636363636364 422 1.5514519631436e-06 222 1.33676066528299 1.30901050948966 1 7.98050577206601 312 320 318 481 448 426 222 422 568 379 423 406 M18779 GO_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBULIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. 151/374 Gene Ontology MF GO:0015631 8.66168944242894e-08 4.3784364214476e-07 270 451 422 7.87426343950099e-09 152 1.5180413904482 1.79215524524337 1 12.84793823215 268 817 351 690 152 708 347 330 449 427 422 407 M19100 GO_CARBON_OXYGEN_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_OXYGEN_LYASE_ACTIVITY.html Catalysis of the breakage of a carbon-oxygen bond. 44/77 Gene Ontology MF GO:0016835 1.60620538037109e-07 6.68646583683891e-07 470 425.363636363636 423 1.46018681603553e-08 198 1.02156389967937 -0.875432752417631 -1 8.39598087751109 466 255 423 592 198 235 630 435 694 410 341 408 M18363 GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. 10/70 Gene Ontology MF GO:0030594 0.000301288525698895 0.000469805836683023 430 469.090909090909 426 2.73936177157547e-05 192 1.30433311609779 -1.30433311609779 -1 5.77783624606909 426 630 391 619 667 317 524 192 622 418 354 409 M18780 GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. 12/29 Gene Ontology MF GO:0015605 9.6103501350606e-06 1.92020572355957e-05 790 480.454545454545 426 8.73672010600326e-07 52 1.0253390373554 -1.04162780750384 -1 6.4370087800435 786 52 407 278 426 611 901 596 352 363 513 410 M18016 GO_ENHANCER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENHANCER_BINDING.html Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. 56/142 Gene Ontology MF GO:0035326 1.0642550015598e-06 2.87940598044728e-06 590 429.363636363636 427 9.67505014905388e-08 73 2.11778525460625 2.42647625067246 1 15.6181334009303 587 427 94 245 314 893 548 487 198 73 857 411 M18613 GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 10/41 Gene Ontology MF GO:0015125 1.81732958213557e-05 3.45442813133208e-05 430 381.090909090909 427 1.65213144956542e-06 89 2.31704717413085 -1.82695861369117 -1 13.7597525163658 427 219 89 119 453 617 461 724 194 183 706 412 M18846 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. 12/25 Gene Ontology MF GO:0015215 9.6103501350606e-06 1.92020572355957e-05 790 480.727272727273 427 8.73672010600326e-07 53 1.0253390373554 -1.04162780750384 -1 6.4370087800435 787 53 408 279 427 612 902 589 353 364 514 413 M18642 GO_ORGANIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BINDING.html Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage. 104/287 Gene Ontology MF GO:0043177 4.83532132456344e-06 1.04670485143491e-05 575 392 428 4.39575632001811e-07 46 2.12470599984427 2.41590999915299 1 14.0840095340895 368 533 46 147 393 716 439 573 428 97 572 414 M18096 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. 6/20 Gene Ontology MF GO:0030169 0.0228046927817587 0.0274611483759398 430 455.363636363636 430 0.00230421539899795 117 2.15315471943845 2.15315471943845 1 4.47444438906038 117 525 664 339 720 410 321 384 669 430 430 415 M18466 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. 17/46 Gene Ontology MF GO:0043027 1.06428679833652e-06 2.87940598044728e-06 625 482.272727272727 430 9.67533921094009e-08 186 2.16806852556403 -1.9866032841234 -1 15.9889599007328 622 483 216 324 315 663 430 864 186 288 914 416 M18865 GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. 24/52 Gene Ontology MF GO:0008375 3.54083187505135e-07 1.20650567594342e-06 490 470.272727272727 430 3.21893858630673e-08 246 1.25499000354608 1.03187459908184 1 9.88627174007192 490 270 415 430 246 778 528 322 422 541 731 417 M18195 GO_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). 19/84 Gene Ontology MF GO:0015297 3.10338173102101e-06 7.15566714922137e-06 375 478.545454545455 431 2.82126009886091e-07 212 1.75272399845572 -1.7162125957352 -1 12.0035922206884 822 414 212 371 372 488 765 569 431 237 583 418 M18936 GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. 8/27 Gene Ontology MF GO:0043325 9.04840543789364e-05 0.000153873068444772 380 450.363636363636 431 9.04877389039294e-06 242 2.16602517234513 2.16602517234513 1 10.9924517566361 379 431 857 274 508 490 387 242 608 522 256 419 M17970 GO_COMPLEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_BINDING.html Interacting selectively and non-covalently with any component or product of the complement cascade. 7/27 Gene Ontology MF GO:0001848 4.04157374467954e-05 7.19196875262124e-05 535 421.454545454545 432 4.04164725099356e-06 177 1.21805568989558 1.2575149822656 1 6.71708414664432 255 432 627 534 482 353 419 177 532 474 351 420 M18037 GO_FMN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FMN_BINDING.html Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 6/14 Gene Ontology MF GO:0010181 1.98563586091207e-05 3.75109854628152e-05 650 468.363636363636 434 1.98565360350917e-06 311 1.02297827514632 -1.02297827514632 -1 6.02622047777255 381 397 647 559 458 311 434 552 648 429 336 421 M17949 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 14/38 Gene Ontology MF GO:0001106 6.69351085147258e-07 1.9993603842061e-06 435 439.454545454545 435 6.08501171634312e-08 102 0.947436927139681 -0.773388310582573 -1 7.1868739080259 435 102 390 393 287 594 350 792 507 535 449 422 M18625 GO_DEATH_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). 16/23 Gene Ontology MF GO:0005123 9.79030812787165e-05 0.000165267586745723 425 448.909090909091 435 8.9006762158557e-06 177 0.995897780992098 -0.997808249533125 -1 5.01299724493174 424 435 428 497 506 183 259 885 555 589 177 423 M18485 GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of modified amino acids from one side of a membrane to the other. 6/17 Gene Ontology MF GO:0072349 3.77640038078859e-05 6.7724919109659e-05 365 413.909090909091 436 3.77646455772279e-06 102 1.54783225588224 1.98899385633963 1 8.58943820118984 365 492 751 392 514 319 120 485 577 436 102 424 M17865 GO_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. 248/804 Gene Ontology MF GO:0008233 3.19337303241756e-08 2.33166919827314e-07 705 458 438 2.90306643524584e-09 51 1.63483074057814 -1.37407491553106 -1 14.4318471193405 701 447 258 865 93 51 752 869 438 289 275 425 M19155 GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. 25/52 Gene Ontology MF GO:0019205 1.19966852122031e-05 2.36337267563745e-05 160 445.272727272727 438 1.09061369373561e-06 156 0.769006017122141 -0.793137469467905 -1 4.73545816689934 160 624 518 686 438 156 216 281 814 786 219 426 M17960 GO_SYNTAXIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_BINDING.html Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. 48/123 Gene Ontology MF GO:0019905 1.46805236556593e-06 3.7516893786685e-06 695 469.090909090909 440 1.33459395017554e-07 253 1.11978048850159 -0.945965055397412 -1 8.08681102857259 692 253 419 467 333 329 671 653 623 280 440 427 M19207 GO_ACYL_COA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. 11/19 Gene Ontology MF GO:0003995 0.00413710261285795 0.00540644091453028 380 497.363636363636 440 0.000376809362092993 226 0.805060923962942 -0.786641892682324 -1 2.42929272191231 411 440 481 551 822 226 377 286 774 726 377 428 M18874 GO_RAC_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GTPASE_BINDING.html Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. 29/56 Gene Ontology MF GO:0048365 1.19173292714657e-08 1.74030840154737e-07 370 465.090909090909 441 1.08339357600195e-09 31 1.16138003868927 1.27134590456978 1 10.4487323166992 615 46 366 424 31 789 441 583 578 368 875 429 M18906 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. 9/30 Gene Ontology MF GO:0031435 2.64635733383667e-06 6.22672313843921e-06 390 482 441 2.64636048528516e-07 256 0.803033387818009 -0.756833256232393 -1 5.56415029939242 386 441 846 546 368 256 355 460 586 696 362 430 M19080 GO_C_C_CHEMOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_C_CHEMOKINE_RECEPTOR_ACTIVITY.html Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. 2/13 Gene Ontology MF GO:0016493 0.00477690101378094 0.00619851753551264 355 473.9 441.5 0.000531897033754347 235 1.65759813842582 1.65759813842582 1 4.87084632444355 351 603 890 NA 705 429 235 309 272 454 491 431 M19117 GO_RECEPTOR_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INHIBITOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. 5/14 Gene Ontology MF GO:0030547 0.00283851923297506 0.00379569432316432 250 497.090909090909 442 0.000284215150065523 227 1.18549338654456 1.18549338654456 1 3.8196570960468 248 659 897 442 620 346 227 355 792 386 496 432 M19060 GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. 3/11 Gene Ontology MF GO:0008331 0.0140140823023427 0.0172365718157156 280 490 444 0.00141032522886963 217 1.3092464332345 1.3092464332345 1 3.07320563913375 277 565 883 444 685 376 217 373 768 278 524 433 M18035 GO_GUANYLATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYLATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + GMP = ADP + GDP. 7/16 Gene Ontology MF GO:0004385 6.32734310612412e-05 0.000109833125615739 255 409.727272727273 445 6.32752327206249e-06 124 0.97428396999414 -0.97428396999414 -1 5.13432128559061 252 540 645 445 494 144 160 229 824 650 124 434 M17983 GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. 2/28 Gene Ontology MF GO:0022835 0.00191620553097778 0.00261559211943555 445 493 446 0.000213093270348422 263 1.72211528455808 -1.72211528455808 -1 5.91934320855139 442 445 629 NA 682 358 474 263 766 447 424 435 M18243 GO_MANGANESE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_BINDING.html Interacting selectively and non-covalently with manganese (Mn) ions. 33/69 Gene Ontology MF GO:0030145 3.32144233446938e-06 7.63931736927957e-06 720 528.181818181818 446 3.01949759001452e-07 293 1.2131447033868 -1.32962097688486 -1 8.26239899226422 716 293 388 636 373 400 886 446 546 681 445 436 M19027 GO_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. 383/1167 Gene Ontology MF GO:0043565 2.40979398023002e-07 8.9727670936981e-07 430 525.090909090909 447 2.19072204017225e-08 224 1.56500842809737 1.82567758780272 1 12.59635022181 429 677 269 836 224 917 429 497 447 328 723 437 M19119 GO_CADHERIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CADHERIN_BINDING.html Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. 11/34 Gene Ontology MF GO:0045296 1.60492422663561e-05 3.0954513385844e-05 655 437.090909090909 447 1.45903266804923e-06 127 1.98781859975793 -1.72264812072035 -1 11.9307119092549 653 127 175 133 447 881 662 476 266 207 781 438 M17903 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. 6/30 Gene Ontology MF GO:0031434 4.01079726180777e-06 8.95614922539598e-06 540 505.090909090909 448 4.01080450074876e-07 202 0.855340535156823 -0.826576119350812 -1 5.74686116230664 538 387 616 428 385 369 661 448 702 820 202 439 M18276 GO_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_ACTIVITY.html Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 2/27 Gene Ontology MF GO:0008066 0.00190800896832802 0.00260827377542612 450 501.3 448 0.000212180990442929 262 1.72211528455808 -1.72211528455808 -1 5.92213241361929 443 446 703 NA 683 359 475 262 767 450 425 440 M18432 GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 130/334 Gene Ontology MF GO:0005085 5.62922007966161e-08 3.27777371727131e-07 470 463.181818181818 448 5.11747293063502e-09 116 1.37600303802624 -1.39275350591505 -1 11.8760874643486 468 116 270 352 127 895 526 763 448 213 917 441 M18126 GO_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 93/233 Gene Ontology MF GO:0019207 2.63528123389584e-08 2.15926568991322e-07 485 479.636363636364 449 2.39571024132972e-09 82 1.5781535593814 1.8312854284762 1 14.0015921167619 484 593 321 443 82 915 449 570 330 407 682 442 M18458 GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. 5/19 Gene Ontology MF GO:0005229 4.77046500816196e-06 1.03510089799741e-05 835 518.363636363636 450 4.77047524899428e-07 159 2.06372318657278 1.48538299830232 1 13.6930725576844 833 325 745 450 395 850 652 159 201 219 873 443 M18110 GO_RHO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GTPASE_BINDING.html Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. 51/106 Gene Ontology MF GO:0017048 4.3171015099429e-07 1.40343936012278e-06 460 493.545454545455 451 3.92463850645101e-08 259 1.15015253516688 1.30011904834439 1 8.95988366181854 460 347 437 600 259 729 392 451 594 372 788 444 M18137 GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic hydroxy compound from one side of the membrane to the other. 27/92 Gene Ontology MF GO:1901618 1.11407702001249e-07 5.12475429205748e-07 125 446.818181818182 452 1.01279734220837e-08 35 2.40138281918143 -2.16511197517706 -1 20.1056179221969 744 121 35 126 452 898 595 688 259 123 874 445 M19184 GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. 39/108 Gene Ontology MF GO:0000980 5.46718207980906e-07 1.68220987071048e-06 520 390.636363636364 453 4.97016676222685e-08 98 2.54242082262345 2.84528404111493 1 19.5396164587672 517 504 98 162 276 784 453 475 133 115 780 446 M18405 GO_NUCLEOSIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. 7/14 Gene Ontology MF GO:0019206 0.000287290545804738 0.000450267976389026 405 490.181818181818 454 2.87327693699969e-05 201 0.800767047354142 -0.875704597020179 -1 3.56683866571478 402 454 733 614 550 213 240 296 826 863 201 447 M19174 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. 4/12 Gene Ontology MF GO:0016861 0.00242055985456992 0.00326527135807086 355 535.363636363636 454 0.000242320050314395 339 0.683973084252894 -0.683973084252894 -1 2.2632724769959 352 433 906 404 618 339 412 511 547 913 454 448 M19066 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. 33/67 Gene Ontology MF GO:0016655 0.000429725695761999 0.000651314069359208 100 416.636363636364 458 3.90736051803464e-05 98 0.802286557200543 -0.802286557200543 -1 3.40240908998828 98 489 576 458 611 126 155 295 752 759 264 449 M18622 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. 10/17 Gene Ontology MF GO:0016646 0.00117678487680004 0.00167074396088894 590 442.636363636364 459 0.000107037710311459 69 2.31140810359189 -2.53707409641558 -1 8.54376656241861 459 463 240 287 590 589 345 858 69 420 549 450 M18628 GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 32/82 Gene Ontology MF GO:0005089 1.1340569233827e-06 3.02994609716876e-06 325 540.090909090909 459 1.03096137087933e-07 156 1.48214390942936 -1.81512041344577 -1 10.8867770374371 882 329 322 459 321 803 777 895 310 156 687 451 M18278 GO_PEPTIDASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 25/51 Gene Ontology MF GO:0016504 1.0289465103685e-06 2.82576355086274e-06 815 505.909090909091 460 9.3540635600922e-08 183 1.32246485932082 -1.12067435485285 -1 9.76722101352394 814 183 335 277 310 460 743 810 370 465 798 452 M18378 GO_PALMITOYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. 19/36 Gene Ontology MF GO:0016409 3.49317656717222e-06 7.98195812148856e-06 45 369.818181818182 461 3.17562010334237e-07 41 0.983769290297944 -1.04739841214704 -1 6.67523445377666 258 461 467 626 530 41 139 216 645 644 41 453 M19139 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. 63/141 Gene Ontology MF GO:0001085 2.70294009808993e-07 9.71369097751067e-07 630 475.545454545455 461 2.45721857288697e-08 162 1.55724420162974 1.92712857612939 1 12.462436578626 628 363 292 471 232 816 513 461 396 162 897 454 M18118 GO_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_LIPASE_ACTIVITY.html Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. 2/30 Gene Ontology MF GO:0004806 0.0458222800012449 0.0533626551913232 465 551.4 463 0.00519814658646978 406 2.1733896081392 -2.1733896081392 -1 3.68186341179166 462 622 666 NA 700 406 457 444 845 448 464 455 M17986 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 12/29 Gene Ontology MF GO:0016894 0.00057377411179307 0.000851406746531652 460 566.818181818182 464 5.21748918567302e-05 370 1.02919782729235 -1.28726796058875 -1 4.20533456378867 456 738 444 765 567 396 464 370 847 730 458 456 M18508 GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the rate of NTP hydrolysis by a NTPase. 173/380 Gene Ontology MF GO:0060589 2.05505584615369e-09 5.90828555769187e-08 400 481.909090909091 464 1.8682325891576e-10 1 1.43742087194596 -1.18847803620942 -1 13.8298427351514 685 86 288 396 1 715 714 689 398 464 865 457 M18991 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/50 Gene Ontology MF GO:0016667 0.00142870497808655 0.00199455019702523 365 501.545454545455 465 0.000129966694522446 178 1.40185151653116 -1.40185151653116 -1 5.03817728746864 363 756 385 782 677 178 465 284 790 607 230 458 M18204 GO_NADPH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADPH_BINDING.html Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. 9/16 Gene Ontology MF GO:0070402 2.38763951062929e-07 8.92938353568679e-07 730 460.818181818182 466 2.38763976716634e-08 84 1.40117152913694 -1.04663865021202 -1 11.2815946757783 729 232 686 84 230 466 708 632 440 257 605 459 M18335 GO_O_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. 11/20 Gene Ontology MF GO:0008171 0.000149271698022928 0.000245670773132547 725 497.909090909091 466 1.35710751986404e-05 174 1.14214006134174 -1.14214006134174 -1 5.48740199674817 451 723 466 845 521 225 314 301 736 721 174 460 M18714 GO_STEROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a steroid hormone receptor. 46/118 Gene Ontology MF GO:0035258 2.73419439926665e-08 2.15926568991322e-07 645 478.545454545455 466 2.48563130295242e-09 84 1.33254888004492 -1.14176244313629 -1 11.8225539535062 642 381 399 472 84 297 682 863 534 444 466 461 M19031 GO_DEATH_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_ACTIVITY.html Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. 12/23 Gene Ontology MF GO:0005035 0.00018241189138441 0.000292877731367639 495 450.636363636364 468 1.6584274339124e-05 183 2.3940843884433 3.11340184304183 1 11.2591195934863 491 610 289 429 535 810 468 210 183 619 313 462 M18824 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. 29/69 Gene Ontology MF GO:0030374 9.16082504674538e-07 2.59321816707869e-06 545 465.272727272727 469 8.32802623756872e-08 259 1.0038610575029 -0.910011904743417 -1 7.46396878580924 544 458 469 342 302 308 514 600 687 635 259 463 M18904 GO_TETRAPYRROLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BINDING.html Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. 38/185 Gene Ontology MF GO:0046906 3.12084330189136e-05 5.69677745583343e-05 365 448.636363636364 470 2.83717052178697e-06 128 1.55583017994658 1.77449166196427 1 8.78938074336606 364 256 158 410 470 725 536 708 526 128 654 464 M18590 GO_NEUROPILIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPILIN_BINDING.html Interacting selectively and non-covalently with a member of the neuropilin family. 6/15 Gene Ontology MF GO:0038191 0.000346226770117396 0.000534444007563765 475 401.545454545455 471 3.46280724788143e-05 79 2.26250260170905 2.26250260170905 1 9.85367290332446 90 471 775 557 616 170 79 471 533 438 217 465 M17932 GO_NARROW_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NARROW_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. 6/17 Gene Ontology MF GO:0022842 6.08270790637382e-06 1.28350717290457e-05 710 482.181818181818 472 6.08272455613893e-07 200 1.75028907674252 -0.999783121227577 -1 11.3957695140387 709 354 622 200 407 817 472 500 445 266 512 466 M18557 GO_SUMO_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. 10/17 Gene Ontology MF GO:0019789 0.00363902934084664 0.00478956651441904 270 534.818181818182 473 0.000331369331906775 188 0.856919593754543 0.856919593754543 1 2.64578922293926 267 871 473 760 766 299 188 387 881 709 282 467 M19227 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. 30/72 Gene Ontology MF GO:0043028 1.46808119777928e-05 2.85546448616689e-05 910 592.272727272727 473 1.33462817683463e-06 316 1.533398264533 -1.30349663277699 -1 9.27485138081928 909 466 316 427 441 758 799 873 393 473 660 468 M18934 GO_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVITY.html Catalysis of the hydrolysis of a lipid or phospholipid. 38/132 Gene Ontology MF GO:0016298 9.65882946750044e-08 4.72666122877681e-07 130 475.636363636364 475 8.78075444687226e-09 128 1.99546295118712 -1.89078516035867 -1 16.8003214085052 726 365 128 475 159 879 488 749 270 129 864 469 M17854 GO_COFACTOR_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORTER_ACTIVITY.html Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. 11/23 Gene Ontology MF GO:0051184 8.56193381997426e-06 1.75043980319474e-05 720 475.636363636364 477 7.78360649217087e-07 204 1.6704679314791 -1.61288138837293 -1 10.57646753487 718 485 273 659 419 450 614 388 477 204 545 470 M19028 GO_GTP_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. 14/22 Gene Ontology MF GO:0030742 0.00143505556920351 0.00199735419616827 230 441 477 0.000130544773527468 167 0.882222285764465 -0.869654371451446 -1 3.1699415288903 230 477 483 689 612 167 278 300 672 670 273 471 M17971 GO_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for hormones. 89/307 Gene Ontology MF GO:0051427 4.50833117654587e-08 2.92089062142408e-07 265 503.545454545455 478 4.09848297175678e-09 111 1.38230470518187 -1.14181441301499 -1 12.022586809301 748 292 378 261 111 645 888 650 478 265 823 472 M18113 GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. 15/37 Gene Ontology MF GO:0045309 0.00178962565372442 0.00245739642003951 455 493.909090909091 478 0.000162825737619835 241 1.15745789856687 -1.24706631456512 -1 4.0202154860271 452 597 478 375 646 261 551 340 741 751 241 473 M18568 GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. 17/31 Gene Ontology MF GO:0004683 0.000152919171628157 0.000251224353389115 550 511.090909090909 478 1.39027092616043e-05 273 1.25923383993023 1.25535235033448 1 6.03370657229564 548 273 369 478 522 740 452 625 458 380 777 474 M18003 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 49/105 Gene Ontology MF GO:0016651 3.94642623980802e-05 7.0362638384174e-05 105 402.636363636364 479 3.58772457615276e-06 70 1.02530059880142 -0.966942209597458 -1 5.6670899472511 101 573 557 700 479 70 89 218 747 713 182 475 M18793 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin-like growth factor receptor. 6/26 Gene Ontology MF GO:0005159 0.000356917992169587 0.000549104603337826 330 506.090909090909 479 3.56975330835216e-05 328 1.15079030047251 1.15079030047251 1 4.99393021099733 329 362 819 528 556 430 335 328 772 629 479 476 M18499 GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. 33/77 Gene Ontology MF GO:0000979 9.94253215606689e-05 0.000167529845853142 495 455.272727272727 480 9.03907410965041e-06 205 1.14794849892958 -0.947703194065248 -1 5.76934526485657 492 579 445 474 507 205 480 344 614 531 337 477 M18214 GO_NEUROPEPTIDE_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_HORMONE_ACTIVITY.html The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. 8/29 Gene Ontology MF GO:0005184 0.000189003777352361 0.000302932883561276 395 508.636363636364 481 1.89019854369386e-05 248 3.08449084280906 2.35792157649946 1 14.4458397764281 395 591 690 743 537 423 248 738 400 349 481 478 M19091 GO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_BINDING.html Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. 167/380 Gene Ontology MF GO:0051020 8.2871914064431e-09 1.54018898320046e-07 830 483.090909090909 481 7.53381039787287e-10 16 1.2320746570979 -1.09129867735764 -1 11.1717602682771 828 33 404 418 16 481 721 878 515 370 650 479 M18210 GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY.html Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 7/13 Gene Ontology MF GO:0009982 0.00502016920072561 0.00648673548408365 380 502.727272727273 482 0.000503154633479843 283 0.773013610602593 -0.773013610602593 -1 2.25118851089341 283 491 688 482 642 301 376 380 631 848 408 480 M18655 GO_ANNEALING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANNEALING_ACTIVITY.html A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide. 7/15 Gene Ontology MF GO:0097617 0.0212825772968941 0.0256955001484811 385 559.363636363636 482 0.00214891944203584 299 4.56341587403207 4.56341587403207 1 9.65848453848492 299 872 793 382 919 606 454 482 304 659 383 481 M19109 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS.html Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). 29/59 Gene Ontology MF GO:0016763 9.43139417302696e-09 1.60683011836756e-07 470 467.636363636364 482 8.57399473950849e-10 22 1.23497762475332 1.71551405947881 1 11.1678439766665 467 482 381 542 22 819 576 298 275 700 582 482 M18294 GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription. 13/36 Gene Ontology MF GO:0001103 0.000446330287319928 0.000674259218939793 875 511.454545454545 484 4.05837148524418e-05 281 1.74427779529485 2.09541394022437 1 7.3623822907086 874 392 357 484 558 416 644 526 432 281 662 483 M18443 GO_RNA_POLYMERASE_CORE_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_CORE_ENZYME_BINDING.html Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. 11/29 Gene Ontology MF GO:0043175 9.36709458159815e-05 0.000158998653414581 505 462 485 8.51590312249203e-06 311 1.08584203998039 1.17219832740751 1 5.49001718232175 348 311 453 485 502 548 353 504 466 602 510 484 M18922 GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING.html Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. 9/24 Gene Ontology MF GO:0031683 8.84533522138588e-06 1.78775373420554e-05 490 510.727272727273 486 8.84537042956294e-07 189 1.8446142648056 1.60021612053234 1 11.6565737530271 488 486 850 480 429 496 189 795 540 396 469 485 M18580 GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 44/102 Gene Ontology MF GO:0004725 4.66399747078606e-07 1.47733098636399e-06 490 558.090909090909 487 4.2399985995939e-08 267 1.15472006497751 1.2311003063538 1 8.96121588356498 487 342 373 635 267 842 423 839 617 484 830 486 M18760 GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 307/779 Gene Ontology MF GO:0000988 1.74695656320713e-08 1.87474234565248e-07 670 490.454545454545 487 1.58814234279928e-09 52 1.52350167331133 -1.33532446158138 -1 13.6411482494242 667 278 368 434 52 544 620 905 293 487 747 487 M18774 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. 6/15 Gene Ontology MF GO:0016307 4.86429036909326e-05 8.53057294719191e-05 270 449.636363636364 487 4.86439684831717e-06 105 1.31518531002839 -1.31518531002839 -1 7.12294721285338 266 487 815 436 765 117 266 512 550 627 105 488 M18832 GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 14/25 Gene Ontology MF GO:0005086 3.0482117417351e-06 7.06386600099822e-06 490 529.545454545455 488 2.77110542290498e-07 200 1.35566973945747 -1.9189717658396 -1 9.29447041930724 855 490 382 334 369 877 462 828 200 540 488 489 M19187 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 16/26 Gene Ontology MF GO:0016645 5.79634971068574e-05 0.000100806081924969 515 490.272727272727 489 5.26954766636431e-06 151 1.69623477850036 -1.72657411015027 -1 9.02298005675953 512 422 274 407 489 667 337 850 151 590 694 490 M18041 GO_ANKYRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANKYRIN_BINDING.html Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. 12/49 Gene Ontology MF GO:0030506 0.000128000088170332 0.000212563323315352 465 459.909090909091 490 1.16370487327264e-05 116 1.83982431622777 2.31709182694191 1 8.9933669468133 464 697 308 426 516 664 490 196 116 491 691 491 M19171 GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any O-glycosyl bond. 39/105 Gene Ontology MF GO:0004553 6.90982005377402e-06 1.44478055669821e-05 820 580.454545454545 490 6.281674324019e-07 194 1.58502278259646 -1.30018254131984 -1 10.2113092437988 816 304 194 490 409 671 907 841 436 401 916 492 M19021 GO_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. 189/493 Gene Ontology MF GO:0005543 9.10011332978952e-09 1.60588455503452e-07 855 479.272727272727 491 8.2728303340285e-10 18 1.51898152676289 -1.27183377922254 -1 13.736594894225 851 399 150 476 18 549 738 821 491 79 700 493 M18262 GO_DAMAGED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DAMAGED_DNA_BINDING.html Interacting selectively and non-covalently with damaged DNA. 39/77 Gene Ontology MF GO:0003684 0.000177235046335308 0.000285063361238608 110 411.181818181818 492 1.61135751133325e-05 106 1.09695145028544 -0.833197495874557 -1 5.17599153900116 106 520 492 522 533 163 206 598 338 728 317 494 M18046 GO_PROTEIN_DIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DIMERIZATION_ACTIVITY.html The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. 581/1514 Gene Ontology MF GO:0046983 1.81191829716027e-08 1.87474234565248e-07 565 430.545454545455 493 1.81191831193398e-09 37 1.70599546289039 -1.4709122281332 -1 15.275163556613 564 132 650 263 62 493 594 744 387 37 810 495 M18140 GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). 5/20 Gene Ontology MF GO:0015299 0.00129798520283178 0.00182870809587326 495 487 493 0.000129874397117114 130 3.2467924711424 -3.73296295246194 -1 11.8317193563352 652 493 671 350 597 513 601 492 130 382 476 496 M18297 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. 43/95 Gene Ontology MF GO:0004722 1.05274789254266e-07 4.99049876732637e-07 500 503.545454545455 496 9.57043584471768e-09 124 1.39830228932257 -0.653869808065133 -1 11.7287663701304 496 784 486 589 164 905 416 268 124 712 595 497 M18857 GO_SNARE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_BINDING.html Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 68/160 Gene Ontology MF GO:0000149 1.20950288473073e-06 3.18837436662541e-06 330 473.727272727273 496 1.09954868153139e-07 220 1.10573530149556 -0.95350511793527 -1 8.08936999149342 511 328 496 722 328 220 610 530 670 425 371 498 M18885 GO_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_BINDING.html Interacting selectively and non-covalently with any enzyme. 957/2452 Gene Ontology MF GO:0019899 2.05259645170484e-08 1.97084047342755e-07 500 496.727272727273 496 2.05259647066403e-09 72 1.44877284128594 1.7648237774037 1 12.9301762547399 481 196 839 756 72 584 500 496 455 339 746 499 M18396 GO_CARBON_CARBON_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_CARBON_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 20/54 Gene Ontology MF GO:0016830 0.000378890966521538 0.000579999482861589 665 478.272727272727 497 3.44505669146753e-05 176 1.23751173973767 -1.3978618979047 -1 5.33110687093835 446 664 364 708 592 272 497 302 665 575 176 500 M18462 GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. 16/35 Gene Ontology MF GO:0004033 1.26165341734168e-07 5.50657978498022e-07 715 519 497 1.1469577179044e-08 181 1.75218888510285 -1.82501233422786 -1 14.5974454744417 714 218 299 322 181 900 621 877 497 260 820 501 M17952 GO_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 13/38 Gene Ontology MF GO:0019212 6.94029280239902e-07 2.05969979942164e-06 290 475.090909090909 499 6.30935908349025e-08 8 2.27244948844824 -2.00153269636626 -1 17.1988287437184 680 484 287 225 289 499 724 860 8 525 645 502 M18348 GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. 163/410 Gene Ontology MF GO:0042578 1.65787530306217e-08 1.87474234565248e-07 390 503.454545454545 499 1.5071593777778e-09 50 1.43049995333343 1.77816497277484 1 12.8084282188451 387 702 375 835 50 801 308 499 444 533 604 503 M18620 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. 24/54 Gene Ontology MF GO:0004520 8.23152706028084e-05 0.000140762172778037 225 481.090909090909 500 7.48348642499617e-06 138 0.847060109552439 -0.841823867579529 -1 4.34238603082312 224 680 526 806 500 138 241 424 743 753 257 504 M18252 GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS.html Catalysis of the hydrolysis of any ester bond. 329/826 Gene Ontology MF GO:0016788 1.87710541323907e-08 1.89773294525269e-07 645 476.636363636364 501 1.706459481141e-09 59 1.34548413221318 -1.11540137043312 -1 12.0377325081554 641 566 476 889 59 59 748 501 446 643 215 505 M18514 GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. 3/12 Gene Ontology MF GO:0008970 0.00542835405483344 0.00695555115661109 425 566.818181818182 501 0.00054416599853712 253 2.34985536413799 2.34985536413799 1 6.74852093165856 421 816 758 780 850 357 253 311 771 501 417 506 M19198 GO_OXIDIZED_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDIZED_NAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. 7/18 Gene Ontology MF GO:0070403 4.68995163156135e-05 8.28168042425421e-05 785 550.090909090909 501 4.69005061490985e-06 60 0.679772821613883 -0.676704307269851 -1 3.69323451636148 501 60 913 301 485 391 550 781 783 919 367 507 M18130 GO_ATPASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_REGULATOR_ACTIVITY.html Modulates the rate of ATP hydrolysis by an ATPase. 21/45 Gene Ontology MF GO:0060590 3.51286234045728e-07 1.20142503837201e-06 840 542.181818181818 502 3.19351172852334e-08 245 0.987881335929741 -1.16319290994576 -1 7.78451400817378 837 284 487 502 245 541 881 266 464 742 715 508 M18935 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION.html Any protein binding that is involved in cell-cell adhesion. 6/15 Gene Ontology MF GO:0098632 5.4958905333683e-08 3.24116621198643e-07 165 480.545454545455 502 5.49589066928996e-09 21 3.07591022222069 -3.07591022222069 -1 26.5677167957557 502 658 856 483 764 333 712 21 165 631 161 509 M18728 GO_METALLOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 58/200 Gene Ontology MF GO:0008237 3.97683638246597e-07 1.30639912617626e-06 490 544.636363636364 503 3.61530645576377e-08 257 1.46732596151129 -0.986626242434469 -1 11.4914928816847 619 503 337 814 257 800 544 419 486 486 726 510 M17876 GO_SYNTAXIN_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_1_BINDING.html Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. 9/27 Gene Ontology MF GO:0017075 0.000307764944039597 0.000479092637083637 335 462.090909090909 505 3.07807576016914e-05 197 1.13227794499614 1.35288549006607 1 5.00286729004399 332 506 612 486 637 505 380 197 588 545 295 511 M18478 GO_DOUBLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA. 317/898 Gene Ontology MF GO:0003690 4.26802196734259e-08 2.82487784888862e-07 505 530.727272727273 505 3.88002004558422e-09 107 1.5518038367565 1.77663488511463 1 13.5267862585694 505 632 298 885 107 776 479 588 416 315 837 512 M18547 GO_AMIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BINDING.html Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 125/369 Gene Ontology MF GO:0033218 3.28419460813207e-07 1.14017322244585e-06 435 506.545454545455 505 2.9856319076381e-08 208 1.74974556498767 1.98536300090889 1 13.8409391036018 434 527 208 801 242 886 581 505 484 316 588 513 M17910 GO_VITAMIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 12/33 Gene Ontology MF GO:0051183 4.37161927934892e-05 7.73440334038654e-05 440 504.454545454545 506 3.97427831836182e-06 184 1.71901999265526 1.54542901992403 1 9.40744591349681 436 429 184 521 481 756 578 797 506 242 619 514 M18913 GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY.html Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 11/62 Gene Ontology MF GO:0008227 7.58133918581194e-07 2.22128409265827e-06 260 523.090909090909 506 6.89212890762786e-08 54 1.9072056702903 1.9072056702903 1 14.3512498293204 259 896 354 870 848 506 431 54 548 604 384 515 M18061 GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. 37/89 Gene Ontology MF GO:0005546 5.61809599595277e-05 9.8076818145665e-05 295 555.909090909091 509 5.10749042661446e-06 293 1.62970195222234 -1.66620690337844 -1 8.69492131554607 888 629 295 293 487 722 754 453 509 367 718 516 M18162 GO_SEROTONIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_ACTIVITY.html Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. 2/14 Gene Ontology MF GO:0099589 0.00427653569746801 0.00557282272191299 385 543.5 509 0.000476076220958204 304 3.09723556134655 3.09723556134655 1 9.29172677241904 385 648 679 NA 711 476 518 304 765 449 500 517 M18577 GO_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BINDING.html Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. 29/74 Gene Ontology MF GO:0051287 6.36988200013052e-08 3.53029604826511e-07 450 541.909090909091 509 5.79080198596742e-09 135 1.11812398436779 -0.958691235622123 -1 9.60240046235534 690 448 446 509 135 441 810 748 682 543 509 518 M18836 GO_CARBONATE_DEHYDRATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBONATE_DEHYDRATASE_ACTIVITY.html Catalysis of the reaction: H2CO3 = CO2 + H2O. 8/14 Gene Ontology MF GO:0004089 0.000665018462237021 0.000980475937913556 245 491.909090909091 509 6.65217558396931e-05 236 1.88939467852904 2.03387288605061 1 7.56596923246984 241 742 826 688 570 332 236 509 662 354 251 519 M18040 GO_S_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. 17/29 Gene Ontology MF GO:0016417 0.000154452290598799 0.000252840048667073 265 476.636363636364 511 1.40421031889421e-05 92 0.820504700971204 -0.820504700971204 -1 3.928464402315 265 666 511 746 879 92 121 326 725 760 152 520 M18115 GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING.html Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. 334/977 Gene Ontology MF GO:0001067 3.55155018446601e-08 2.51340474592979e-07 180 502.636363636364 511 3.22868203800013e-09 100 1.54304093753971 1.73724105902869 1 13.5546063441507 521 398 178 825 100 805 511 693 411 176 911 521 M18050 GO_ATPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the ATP hydrolysis activity of an ATPase. 12/24 Gene Ontology MF GO:0001671 2.19111132244326e-05 4.08888928326126e-05 620 530.818181818182 512 1.99193922303012e-06 115 1.32469285185624 -1.64867191041631 -1 7.73755297433537 760 501 389 620 473 512 873 115 365 616 615 522 M18341 GO_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. 20/106 Gene Ontology MF GO:0005253 2.83608488613009e-07 1.00353772893834e-06 920 541.272727272727 512 2.57825931976202e-08 208 1.54097128249 -1.53134903812384 -1 12.3031851199907 916 428 291 568 238 658 858 208 512 458 819 523 M18924 GO_SH3_SH2_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_SH2_ADAPTOR_ACTIVITY.html Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). 24/69 Gene Ontology MF GO:0005070 0.000104996048635425 0.000176270738585019 660 535.636363636364 512 9.5455509051573e-06 275 1.63244304099449 -1.17148493793002 -1 8.15631939261808 658 722 320 422 512 916 625 399 285 275 758 524 M18309 GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. 8/15 Gene Ontology MF GO:0008239 0.00201209500521599 0.00273835414911052 235 465.181818181818 514 0.00020139191670631 205 2.09570270934481 2.09570270934481 1 7.14789343763233 231 586 710 616 614 380 205 297 536 514 428 525 M19195 GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 11/30 Gene Ontology MF GO:0017112 3.78569034637185e-06 8.53636058495614e-06 515 566.363636363636 514 3.44154260062149e-07 230 0.767501214827585 0.845707636074208 1 5.17798426730995 514 230 489 401 379 885 687 826 502 606 711 526 M18455 GO_CO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CO_SMAD_BINDING.html Interacting selectively and non-covalently with a common mediator SMAD signaling protein. 8/19 Gene Ontology MF GO:0070410 2.2398047476617e-07 8.51496019772218e-07 605 442.909090909091 515 2.23980497341437e-08 34 1.94752233761139 -2.82411285466599 -1 15.7340625329497 721 298 744 135 225 605 798 195 34 515 602 527 M19150 GO_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOMERASE_ACTIVITY.html Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. 75/174 Gene Ontology MF GO:0016853 9.10419952613397e-07 2.58514307532199e-06 655 494.727272727273 515 8.27654844882e-08 185 1.52601498645915 -1.13836118704114 -1 11.3490711827147 566 655 376 581 301 185 501 654 496 612 515 528 M17924 GO_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. 110/237 Gene Ontology MF GO:0042393 0.00248361350131057 0.00334542374993518 255 518.454545454545 516 0.000226038339069852 190 1.29523790376275 -1.21857010909266 -1 4.26779705991486 251 792 516 855 628 190 399 358 646 737 331 529 M18421 GO_ADENOSINE_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOSINE_DEAMINASE_ACTIVITY.html Catalysis of the reaction: adenosine + H2O = inosine + NH3. 6/10 Gene Ontology MF GO:0004000 0.000177158969859128 0.000285063361238608 495 541.818181818182 516 1.77173094829255e-05 358 1.21698273832189 -0.977073605556153 -1 5.74236215960582 581 516 737 494 536 446 358 812 493 435 552 530 M19039 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. 6/76 Gene Ontology MF GO:0016712 5.28279224466144e-06 1.13555347315152e-05 445 507 516 5.2828048032557e-07 110 1.47181000730158 1.85472171678407 1 9.68685044242397 444 110 874 516 402 660 651 539 498 272 611 531 M17984 GO_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. 25/47 Gene Ontology MF GO:0033558 0.00319571161721927 0.00424863394196782 520 493 517 0.000290942105275009 213 0.860644050185321 -0.737414048828704 -1 2.71690997479406 565 213 517 446 621 224 517 733 613 648 326 532 M18069 GO_MANNOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. 8/15 Gene Ontology MF GO:0015923 0.00791353202713932 0.0099459692144374 600 504.636363636364 517 0.000794185487705221 286 1.32013748233565 -1.38374843168852 -1 3.51837775948026 599 430 659 517 653 398 286 366 607 509 527 533 M18435 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a functional group from one position to another within a single molecule. 13/27 Gene Ontology MF GO:0016866 0.000160323205678673 0.000261984634501562 480 518.636363636364 518 1.45758991176049e-05 111 1.36724753743194 -0.714094862793296 -1 6.51811535063846 480 640 401 518 525 327 417 887 111 740 659 534 M18039 GO_ATPASE_ACTIVITY_COUPLED http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. 153/347 Gene Ontology MF GO:0042623 0.00138175118649103 0.00193782178593255 385 559.363636363636 519 0.000125692707731189 165 1.55150930399457 -1.14709841910289 -1 5.60191709473608 384 891 519 704 810 165 404 455 618 791 412 535 M18375 GO_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOXYGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. 39/89 Gene Ontology MF GO:0051213 1.58741232056033e-06 4.02319376009779e-06 860 520.090909090909 520 1.4431031508732e-07 196 1.94339306519985 -1.86527144808257 -1 13.9562721625752 859 594 268 524 338 520 868 421 251 196 882 536 M17899 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 10/30 Gene Ontology MF GO:0016675 0.0265788695319955 0.0317153825803318 675 554.545454545455 521 0.00244595593757571 259 0.465848462768493 -0.437522549679858 -1 0.929288062878889 672 259 521 470 676 328 450 745 733 819 427 537 M18303 GO_E_BOX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_E_BOX_BINDING.html Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. 12/40 Gene Ontology MF GO:0070888 3.22047602419086e-05 5.8554109530743e-05 790 506.181818181818 521 2.92774833471227e-06 199 1.6708524970258 -1.23911265049768 -1 9.41265126524617 789 274 199 331 472 680 685 773 521 245 599 538 M18888 GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. 19/27 Gene Ontology MF GO:0003887 0.0451088479916624 0.0525984032348915 795 573.727272727273 521 0.00418738308313127 349 1.15610743988496 -1.28497175267305 -1 1.96816102968163 349 795 493 794 710 461 521 411 712 647 418 539 M18515 GO_ELECTRON_CARRIER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_CARRIER_ACTIVITY.html Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 68/160 Gene Ontology MF GO:0009055 0.000313800977579594 0.000487663681373694 595 523.727272727273 522 2.85314314626844e-05 116 1.37342643819933 -1.11716443520474 -1 6.05428259830047 595 437 417 757 871 116 393 764 522 598 291 540 M19005 GO_P53_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_P53_BINDING.html Interacting selectively and non-covalently with one of the p53 family of proteins. 49/92 Gene Ontology MF GO:0002039 8.99103525670353e-06 1.81001147399721e-05 610 523.454545454545 522 8.17370181980384e-07 323 1.46717242104615 1.96131320757462 1 9.26093136694614 449 541 323 621 423 854 522 469 336 610 610 541 M18753 GO_PROLINE_RICH_REGION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROLINE_RICH_REGION_BINDING.html Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. 13/26 Gene Ontology MF GO:0070064 0.0241053070532706 0.0288761490742304 290 496.727272727273 524 0.00221577743845981 269 0.837361827477803 0.82166257939821 1 1.71579068047436 287 559 524 597 722 340 269 410 630 741 385 542 M19004 GO_RIBONUCLEASE_P_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_P_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. 6/11 Gene Ontology MF GO:0004526 0.000142188907350883 0.000234433323947693 410 558.727272727273 524 1.42198006128684e-05 352 0.6636597530532 -0.6636597530532 -1 3.2065090006711 408 607 868 585 524 352 448 369 680 896 409 543 M19054 GO_DOPAMINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a dopamine receptor. 9/31 Gene Ontology MF GO:0050780 2.16788285280025e-05 4.05376468409802e-05 555 473.363636363636 524 2.1679040018129e-06 110 2.29188402100889 -1.93032636815159 -1 13.3983633215163 553 192 880 110 463 524 819 555 142 554 415 544 M19175 GO_ACID_THIOL_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_THIOL_LIGASE_ACTIVITY.html Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 8/20 Gene Ontology MF GO:0016878 0.0003219491070271 0.00049948259437594 265 511.454545454545 524 3.21995759592272e-05 83 0.51373959123257 -0.51373959123257 -1 2.25753381106007 263 524 907 681 762 118 83 267 873 914 234 545 M17862 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase. 18/31 Gene Ontology MF GO:0051019 8.66352682359358e-06 1.7593680954866e-05 525 585.909090909091 525 7.87596449132921e-07 421 0.906008018548882 -0.940844538417446 -1 5.73367039924103 522 510 480 590 421 697 525 489 781 714 716 546 M18031 GO_ESTROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an estrogen receptor. 18/56 Gene Ontology MF GO:0030331 0.000334953686974836 0.000518783488243854 400 512.545454545455 526 3.04549722825328e-05 277 1.37059445780524 -1.35839548177622 -1 5.992788122525 397 749 397 667 553 277 483 581 708 526 300 547 M18231 GO_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 370/917 Gene Ontology MF GO:0016301 7.79207363033602e-09 1.52525696593811e-07 435 484.909090909091 526 7.08370332539492e-10 14 1.38268939680284 1.60129868183501 1 12.5452368299747 579 152 435 515 14 526 632 585 434 572 890 548 M18124 GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY.html Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 4/26 Gene Ontology MF GO:0015464 0.00126306366816923 0.00178497476914853 525 554.090909090909 527 0.000126378214139496 250 1.45065196881592 -1.45065196881592 -1 5.30665479842102 523 563 667 527 661 522 833 250 769 333 447 549 M18381 GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. 10/24 Gene Ontology MF GO:0005385 0.000167206629957669 0.000271305290231138 575 527.545454545455 528 1.52017581379831e-05 272 1.50808803269696 1.69988554785486 1 7.15907256966893 571 583 272 506 528 701 401 556 505 419 761 550 M18962 GO_MAP_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_ACTIVITY.html Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. 9/17 Gene Ontology MF GO:0004708 0.00115710771768458 0.00164534636826865 530 542.181818181818 528 0.000115771066381308 300 1.10513377586708 1.09371737927515 1 4.09474295363469 528 370 862 300 593 602 336 834 490 397 652 551 M19142 GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 23/47 Gene Ontology MF GO:0016796 0.000573252356382798 0.000851406746531652 230 506.181818181818 528 5.21274348031073e-05 131 0.790864381263744 -0.790864381263744 -1 3.23149636240494 229 657 528 766 662 131 254 507 749 782 303 552 M19213 GO_SEMAPHORIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_ACTIVITY.html Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 3/11 Gene Ontology MF GO:0017154 0.0765897756730953 0.0848946911075273 330 555.909090909091 528 0.00793650793650794 328 1.23382271260051 1.23382271260051 1 1.75902986381113 328 564 918 469 733 477 339 528 633 506 620 553 M17963 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. 14/28 Gene Ontology MF GO:0052866 0.0247996847741598 0.0296693237870313 490 620.363636363636 529 0.00228033948231777 337 1.03069475295945 -1.03069475295945 -1 2.09579382331028 486 826 504 820 860 337 529 381 852 747 482 554 M18534 GO_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVITY.html Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 130/313 Gene Ontology MF GO:0016791 1.55040158340082e-08 1.87474234565248e-07 530 534.454545454545 529 1.40945599484267e-09 45 1.29253118818578 -0.924964420291302 -1 11.5730816643941 529 615 461 674 45 707 426 454 488 705 775 555 M18652 GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). 9/33 Gene Ontology MF GO:0015298 0.000402504620033568 0.00061207314120807 530 568.636363636364 529 4.02577543109892e-05 394 2.23162636780208 -2.58461774932654 -1 9.5442448386184 643 634 791 523 557 458 767 529 430 394 529 556 M18952 GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. 28/83 Gene Ontology MF GO:0070491 0.000164455710298285 0.000267786289335261 405 577.272727272727 529 1.49516368251093e-05 402 1.26706094092796 1.55985519340897 1 6.02445041451806 754 402 441 529 526 552 801 403 590 445 907 557 M19108 GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. 7/11 Gene Ontology MF GO:0008195 0.000743008484997675 0.00108848376783099 610 541.909090909091 529 7.43257029687775e-05 208 1.66342998182341 -1.183692705455 -1 6.56062214723136 608 442 893 247 574 529 519 805 208 483 653 558 M18651 GO_LIPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 14/21 Gene Ontology MF GO:0060229 1.14721780296233e-05 2.26489351657799e-05 585 550.181818181818 530 1.04293071392565e-06 272 1.51117727234588 2.13076973030109 1 9.34285138566725 584 530 360 406 435 882 768 272 403 669 743 559 M18802 GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. 23/61 Gene Ontology MF GO:0005548 0.000557510556925615 0.000832645636966828 815 519.363636363636 530 5.06956261807443e-05 206 1.69118377120752 -1.36191502250203 -1 6.93201318716362 815 411 340 400 564 462 693 540 206 530 752 560 M18372 GO_HSP90_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP90_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. 16/38 Gene Ontology MF GO:0051879 1.55191465064882e-05 3.01215501813696e-05 480 549 531 1.41084145291574e-06 367 1.12173204166997 1.34316320430544 1 6.75022382187451 476 625 475 631 443 620 531 367 678 687 506 561 M17900 GO_QUINONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_BINDING.html Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. 12/20 Gene Ontology MF GO:0048038 5.72970097443413e-06 1.2185330473622e-05 615 516.545454545455 532 5.20883263361489e-07 221 1.68698011355792 -1.1571064078048 -1 11.0342362645737 681 359 221 335 400 532 589 816 520 615 614 562 M18206 GO_CATECHOLAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BINDING.html Interacting selectively and non-covalently with catecholamine. 4/17 Gene Ontology MF GO:1901338 9.62190041914089e-06 1.92020572355957e-05 345 458.545454545455 533 9.62194208083023e-07 102 1.94080343163943 1.94080343163943 1 12.1842330785862 342 637 687 552 602 533 368 102 305 558 358 563 M19204 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 448/1070 Gene Ontology MF GO:0016772 1.18181532426399e-08 1.74030840154737e-07 865 554 533 1.07437757328416e-09 30 1.34226606962881 -1.12438829554626 -1 12.0761323655365 863 455 533 790 30 147 860 868 471 671 406 564 M18371 GO_TRANSCRIPTION_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COFACTOR_BINDING.html Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. 12/34 Gene Ontology MF GO:0001221 0.00052958435621796 0.00079480849546578 535 565.909090909091 534 4.81556255298955e-05 441 1.29910301253627 -1.64169033400267 -1 5.35983281558507 687 549 470 514 562 534 705 498 441 731 534 565 M18103 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. 5/12 Gene Ontology MF GO:0004865 3.22132747533232e-07 1.12258381716126e-06 650 433.454545454545 535 3.2213279422952e-08 3 3.29649332744611 -2.72070717310274 -1 26.1057401193878 649 374 665 30 247 535 574 851 3 217 623 566 M19206 GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS.html Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. 7/13 Gene Ontology MF GO:0016801 0.000164251068626831 0.000267786289335261 535 593 535 1.64263210175978e-05 300 1.54134263083428 -1.66520247856756 -1 7.32856824533796 689 300 916 535 534 848 510 663 454 314 760 567 M18250 GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY.html Functions in chain elongation during polypeptide synthesis at the ribosome. 11/20 Gene Ontology MF GO:0003746 0.0165492965716542 0.0202195920928577 850 590 536 0.0015159194697851 282 0.326818822565381 -0.338060233843206 -1 0.736988904120614 413 779 536 738 846 282 323 428 828 850 467 568 M18585 GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). 20/44 Gene Ontology MF GO:0016776 0.000864336184967761 0.00125440817213823 160 475.272727272727 537 7.86069047580399e-05 150 0.723450099088495 -0.723450099088495 -1 2.79397780879053 157 690 537 672 709 150 187 317 815 774 220 569 M18657 GO_NADH_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. 26/44 Gene Ontology MF GO:0003954 0.00063796395118243 0.000945131779529526 115 468.454545454545 537 5.80135477649962e-05 115 0.707410522960457 -0.707410522960457 -1 2.84779584603919 115 537 587 573 672 134 168 442 848 789 288 570 M17894 GO_PHOSPHOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_BINDING.html Interacting selectively and non-covalently with a phosphorylated protein. 40/84 Gene Ontology MF GO:0051219 1.95958348870707e-07 7.7707621103901e-07 780 540 538 1.7814396938646e-08 212 1.7108459984715 -1.44109226087543 -1 13.9123972311495 777 439 334 243 212 703 753 538 450 571 920 571 M18164 GO_TRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_BINDING.html Interacting selectively and non-covalently with transfer RNA. 17/47 Gene Ontology MF GO:0000049 0.000970228119399056 0.00139470292163614 540 434.272727272727 538 8.82414787972637e-05 162 0.869770290513057 -0.869770290513057 -1 3.3057666318868 162 538 539 562 584 187 219 368 668 701 249 572 M18472 GO_ALPHA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. 16/35 Gene Ontology MF GO:0043014 0.000225261104236258 0.000358547086327609 670 548.454545454545 538 2.04803793041275e-05 235 1.64388313592373 2.17286412470157 1 7.53876378006356 669 529 267 550 538 892 813 437 235 467 636 573 M19033 GO_MISFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with a misfolded protein. 11/19 Gene Ontology MF GO:0051787 0.00492025980089708 0.00636658089567554 535 560.181818181818 538 0.00044829985912457 218 0.987147844159283 -1.04118569958477 -1 2.88546445541801 534 667 421 538 837 218 482 618 830 724 293 574 M18005 GO_CORE_PROMOTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. 95/242 Gene Ontology MF GO:0001047 3.10190203891127e-05 5.67345899761107e-05 470 573.454545454545 539 2.81995070473831e-06 311 1.53770854981616 -1.17544894800123 -1 8.6906517409315 890 628 311 539 469 497 779 765 470 318 642 575 M18307 GO_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids. 100/224 Gene Ontology MF GO:0004518 4.26432218030205e-06 9.38558948774613e-06 345 557.454545454545 539 3.87666404180062e-07 252 1.0862229945953 -0.934686813837213 -1 7.26870685127147 345 768 567 896 384 252 539 532 619 794 436 576 M18430 GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. 13/28 Gene Ontology MF GO:0003950 1.03919301565329e-06 2.84540944762209e-06 890 509.090909090909 539 9.44721369570276e-08 170 0.997606770954601 -0.600711257815998 -1 7.36394742241593 887 170 392 381 311 539 623 609 405 640 643 577 M18626 GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY.html Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. 2/8 Gene Ontology MF GO:0016175 0.00694576190750018 0.00882610629129857 455 539.3 539.5 0.000774144194873525 348 1.78395965845297 1.78395965845297 1 4.87772152539292 631 453 781 NA 652 626 348 372 472 451 607 578 M17880 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. 19/59 Gene Ontology MF GO:0016620 1.49994441789474e-07 6.33004066267506e-07 805 552.272727272727 541 1.36358592741809e-08 193 1.5468703902106 -1.36724648335807 -1 12.7623272004439 804 473 249 541 193 582 883 628 537 441 744 579 M18150 GO_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to an acceptor molecule. 51/114 Gene Ontology MF GO:0016407 0.000244246986934627 0.000386759428536759 265 497 541 2.22067370711104e-05 164 0.950482821796993 -0.854384398058352 -1 4.31724967358979 261 760 577 750 541 164 328 350 667 771 298 580 M18905 GO_3_5_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. 30/52 Gene Ontology MF GO:0008408 0.00014049954833589 0.000232063885940788 225 448.272727272727 541 1.2773501992858e-05 91 0.839463847526866 -0.839463847526866 -1 4.06084603120004 168 616 541 712 585 91 221 299 724 750 224 581 M18967 GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a sodium channel. 18/43 Gene Ontology MF GO:0017080 2.15593827204578e-06 5.16526877677636e-06 625 531 541 1.95994580437063e-07 231 1.64875167362739 -1.93005296647875 -1 11.6021830845168 624 521 231 583 356 604 311 647 541 528 895 582 M18142 GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 12/30 Gene Ontology MF GO:0016891 0.0609941518919191 0.0700557050444014 420 613.090909090909 542 0.00570489870688469 381 0.652957791208046 -0.652957791208046 -1 1.00341968055839 416 812 542 716 818 381 535 443 799 843 439 583 M18419 GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. 11/23 Gene Ontology MF GO:0070003 0.0340257870430979 0.040236149202635 365 565.818181818182 542 0.00314215667733038 318 0.414717956340859 -0.414717956340859 -1 0.770244515351612 361 467 561 548 727 318 433 537 866 864 542 584 M19071 GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 164/384 Gene Ontology MF GO:0003713 3.17418697211728e-08 2.33166919827314e-07 900 526.545454545455 542 2.88562456174077e-09 92 1.53736928203629 -1.3531658008156 -1 13.5714834435182 897 577 377 468 92 442 909 542 333 582 573 585 M17980 GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. 2/15 Gene Ontology MF GO:0047555 0.0692024938784801 0.0787949187725268 545 564.6 542.5 0.00793650793650794 430 1.54576698625938 1.54576698625938 1 2.27038586429247 430 731 628 NA 763 543 445 517 542 446 601 586 M18189 GO_CLATHRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_BINDING.html Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. 29/71 Gene Ontology MF GO:0030276 1.14008241239757e-06 3.03143300406292e-06 770 524.909090909091 543 1.0364390938279e-07 160 1.37248379230193 -1.27702757506872 -1 10.0809023337562 766 307 255 624 324 527 792 842 543 160 634 587 M19219 GO_STRUCTURE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. 74/179 Gene Ontology MF GO:0043566 0.00472524424486043 0.00614014788880169 545 566 543 0.000430493084419658 214 1.70500044804798 -1.39503002662637 -1 5.01946276994122 543 843 431 599 897 214 532 681 465 666 355 588 M18244 GO_RNA_CAP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING.html Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. 11/18 Gene Ontology MF GO:0000339 0.00404800178703305 0.00531264143234009 635 518.272727272727 544 0.000368679032470243 243 0.656790886882034 -0.656790886882034 -1 1.98852847106556 380 698 544 633 634 243 298 324 750 849 348 589 M19023 GO_C_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. 6/20 Gene Ontology MF GO:0016408 0.000273693424771913 0.000430011638817043 435 547.818181818182 544 2.73727139256944e-05 242 1.06047086957244 -1.06047086957244 -1 4.75184907999883 432 470 871 544 548 242 381 857 704 633 344 590 M17921 GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a sulfur compound from one side of the membrane to the other. 6/29 Gene Ontology MF GO:1901682 0.000266652021505441 0.000421511786572175 750 577.909090909091 545 2.66684023395298e-05 358 1.44449044236258 1.83398113606014 1 6.48926764735171 746 396 619 358 545 912 646 491 538 428 678 591 M18207 GO_CALCIUM_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. 36/103 Gene Ontology MF GO:0048306 1.15412349494305e-06 3.05992396353778e-06 850 572.636363636364 545 1.04920372763501e-07 203 1.64080520571498 -1.62475619570243 -1 12.0428524942623 847 457 217 532 325 686 874 778 545 203 835 592 M18456 GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. 90/211 Gene Ontology MF GO:0004721 1.39250665259707e-08 1.87474234565248e-07 435 505 546 1.26591514673731e-09 37 1.25814022011409 -0.947891651593124 -1 11.2651513595447 431 552 458 775 37 790 244 546 410 611 701 593 M18564 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). 9/21 Gene Ontology MF GO:0016755 0.00282041479385429 0.00377697468754868 315 550.636363636364 547 0.000282400083394674 272 1.31962019027805 -1.31962019027805 -1 4.25558483566737 428 740 770 663 750 315 312 447 813 547 272 594 M18666 GO_DEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. 35/77 Gene Ontology MF GO:0004536 0.000193904312925034 0.000310246900680054 140 466.818181818182 548 1.76292186759406e-05 95 0.932543662015967 -0.937969201866317 -1 4.35459420012303 136 761 548 817 568 95 162 313 732 767 236 595 M17935 GO_BHLH_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BHLH_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. 16/36 Gene Ontology MF GO:0043425 8.5528183582474e-06 1.75043980319474e-05 735 570.727272727273 549 7.77531964431582e-07 187 1.23478742712036 -0.824131334430553 -1 7.81798223869106 904 187 329 219 418 734 908 732 549 466 832 596 M18323 GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. 11/19 Gene Ontology MF GO:0010485 0.00200416897281584 0.00273160808146752 235 499.181818181818 550 0.000182363370403155 179 0.527370786862193 -0.527370786862193 -1 1.79947477275189 232 710 550 598 703 179 195 339 796 856 333 597 M18128 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 15/37 Gene Ontology MF GO:0016893 0.0157708784865951 0.019319851142034 310 575.363636363636 551 0.00144409828223544 276 0.652957791208046 -0.652957791208046 -1 1.48962672635016 310 836 551 727 815 276 371 441 798 841 363 598 M18866 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. 9/23 Gene Ontology MF GO:0016863 0.00142863349382201 0.00199455019702523 295 497.454545454545 551 0.000142955277284264 171 0.892994867910041 -0.892994867910041 -1 3.20937403475178 294 551 832 732 681 171 183 312 784 694 238 599 M19201 GO_THIOESTERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTERASE_BINDING.html Interacting selectively and non-covalently with any thioesterase enzyme. 6/16 Gene Ontology MF GO:0031996 4.86798999703886e-05 8.53057294719191e-05 915 594 551 4.86809663829644e-06 315 1.4555874929776 -0.978657566990479 -1 7.88335526838281 702 416 914 315 486 565 911 551 513 440 721 600 M18042 GO_PROTEASOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_BINDING.html Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. 10/20 Gene Ontology MF GO:0070628 0.0716745995532068 0.0813078071380398 555 630.454545454545 552 0.00673837289898863 374 0.388104695877829 -0.346520698105351 -1 0.562995102779884 552 764 498 786 913 374 414 488 864 834 448 601 M19222 GO_SNORNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_BINDING.html Interacting selectively and non-covalently with small nucleolar RNA. 18/31 Gene Ontology MF GO:0030515 0.0239742033518173 0.0288317216780026 475 564.090909090909 552 0.00220359232925551 378 0.96653602277855 -0.901901610559965 -1 1.98133465144249 471 548 509 709 735 449 552 378 558 716 580 602 M18267 GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY.html Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. 7/26 Gene Ontology MF GO:0004012 0.0765897756730953 0.0848946911075273 560 516.272727272727 553 0.00793650793650794 121 2.70620925029641 2.70620925029641 1 3.85817556031398 463 556 701 265 719 730 558 536 121 477 553 603 M17947 GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 5/21 Gene Ontology MF GO:0008308 0.0285125789484761 0.0339347640783933 500 601.727272727273 554 0.00288851600811931 427 0.709192017883932 -0.709192017883932 -1 1.38698921446721 526 518 625 499 680 427 554 691 775 827 497 604 M17991 GO_FATTY_ACYL_COA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_BINDING.html Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. 19/35 Gene Ontology MF GO:0000062 0.00653508389421397 0.00832725371561891 770 588.909090909091 554 0.000595870675361054 232 0.805060923962942 -0.786641892682324 -1 2.228280695942 508 796 554 770 780 232 484 375 820 769 390 605 M18507 GO_PHOSPHOTYROSINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTYROSINE_BINDING.html Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. 7/23 Gene Ontology MF GO:0001784 0.000419341792191519 0.000636624502997025 560 476.363636363636 554 4.19420944606279e-05 246 1.55603133255372 -2.22343001453531 -1 6.61947755338117 554 386 755 268 559 377 557 574 307 657 246 606 M19163 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. 12/82 Gene Ontology MF GO:0016709 2.68929714674025e-05 4.94830675000207e-05 885 564.090909090909 554 2.44484547407344e-06 167 2.17174547528943 -2.01769800959188 -1 12.4457102570237 883 554 210 167 465 793 871 752 280 493 737 607 M18228 GO_S100_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_S100_PROTEIN_BINDING.html Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. 9/20 Gene Ontology MF GO:0044548 2.56358532243871e-07 9.40916799652439e-07 555 563.909090909091 555 2.5635856181774e-08 237 1.44587052053424 -1.86379396629241 -1 11.5977478010586 769 555 693 394 237 554 882 597 658 546 318 608 M19032 GO_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. 50/110 Gene Ontology MF GO:0004540 0.0206338328205597 0.0249449752889815 395 605.454545454545 555 0.00189363070079636 295 1.02211202504397 -0.962573538771604 -1 2.18081688368745 394 834 534 886 844 295 555 406 689 797 426 609 M18992 GO_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. 30/81 Gene Ontology MF GO:0019213 0.00304086888672335 0.00404862427754774 475 534.272727272727 557 0.000276825469738591 197 0.867360190341366 -0.760061124743055 -1 2.76228842693707 474 557 531 564 776 197 446 629 688 703 312 610 M18310 GO_TOXIC_SUBSTANCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIC_SUBSTANCE_BINDING.html Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems. 3/17 Gene Ontology MF GO:0015643 0.0352421962783387 0.0416210790450213 410 574.636363636364 558 0.00358139044227495 382 2.47227051816563 2.47227051816563 1 4.54332536176256 407 701 711 664 756 467 382 407 770 498 558 611 M18330 GO_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. 42/81 Gene Ontology MF GO:0004527 0.00105868818331461 0.00151712325334804 385 553.909090909091 559 9.62907264319154e-05 234 1.15630126114244 -0.836256183186344 -1 4.3385596644617 383 639 479 644 586 234 493 846 559 744 486 612 M18569 GO_MICROFILAMENT_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROFILAMENT_MOTOR_ACTIVITY.html Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 4/31 Gene Ontology MF GO:0000146 2.06301994378842e-05 3.87342520058234e-05 450 474.363636363636 562 2.06303909626946e-06 6 5.81869432397637 5.81869432397637 1 34.1691751757602 448 654 771 229 743 576 523 117 6 562 589 613 M18599 GO_CGMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BINDING.html Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). 4/19 Gene Ontology MF GO:0030553 0.0155837443729896 0.0191160597642006 565 552.909090909091 563 0.00156941191989156 125 2.95837479183292 2.95837479183292 1 6.76723357006712 563 717 778 372 718 785 639 363 125 563 459 614 M18028 GO_MIRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIRNA_BINDING.html Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. 7/25 Gene Ontology MF GO:0035198 0.00187521561437563 0.00256725947206188 410 529.545454545455 565 0.000187679989136482 258 3.56149969168527 3.56149969168527 1 12.2801696591573 410 771 644 565 716 510 315 258 598 649 389 615 M18428 GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS.html Catalysis of the hydrolysis of any glycosyl bond. 49/134 Gene Ontology MF GO:0016798 0.000558716358835227 0.000833094084486887 800 594.545454545455 565 5.08053001835182e-05 280 1.49603641768608 -1.20025691204564 -1 6.13165561891106 797 519 280 658 565 443 673 836 494 555 720 616 M18704 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 14/38 Gene Ontology MF GO:0097472 0.000903998411973622 0.00130561780065264 605 581.636363636364 566 8.22154623925504e-05 425 1.33683990243445 1.80762189568336 1 5.13198154358483 516 709 425 602 582 849 534 473 566 539 603 617 M18097 GO_SERINE_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 88/379 Gene Ontology MF GO:0017171 5.86904331912525e-08 3.35753893513821e-07 690 466.363636363636 567 5.33549406881497e-09 41 2.12892792170969 -1.98328402434146 -1 18.3448871559241 688 340 41 567 128 762 606 715 345 46 892 618 M18261 GO_VITAMIN_D_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. 8/22 Gene Ontology MF GO:0042809 1.4099681204194e-06 3.65084508075275e-06 725 581.090909090909 567 1.40996901502475e-07 336 1.3237219721938 -1.24070878679315 -1 9.58048157340936 723 561 700 441 336 623 846 608 474 513 567 619 M18286 GO_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. 115/269 Gene Ontology MF GO:0035091 1.72652789417277e-07 6.9899320908768e-07 710 550.818181818182 567 1.56957093606198e-08 201 1.44914892083631 -1.27145177982555 -1 11.8730159260083 706 745 325 678 201 409 894 729 567 344 461 620 M18629 GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. 2/22 Gene Ontology MF GO:0015106 0.0692024938784801 0.0787949187725268 510 586.3 567 0.00793650793650794 231 2.20286278469046 2.20286278469046 1 3.23551308265221 506 444 783 NA 793 628 476 880 231 452 670 621 M17853 GO_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently with a polymer of ubiqutin. 25/46 Gene Ontology MF GO:0031593 3.03289568761541e-06 7.04612129446004e-06 225 447.090909090909 568 2.75718169885451e-07 32 0.720923697451493 -0.698258052967657 -1 4.94369977845724 225 617 568 759 658 32 182 289 737 785 66 622 M18317 GO_SNAP_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNAP_RECEPTOR_ACTIVITY.html Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. 20/39 Gene Ontology MF GO:0005484 5.70706888489847e-05 9.94413517823218e-05 570 624.363636363636 568 5.18837903510686e-06 488 0.576082324416053 -0.610829845282276 -1 3.06896039039175 609 547 566 671 488 517 694 502 853 853 568 623 M17962 GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. 6/15 Gene Ontology MF GO:0034483 0.00033960204827063 0.000525098965393243 605 510.181818181818 569 3.39653957733767e-05 201 1.46708643351819 1.46708643351819 1 6.404428241123 601 517 626 413 675 735 569 201 214 620 441 624 M19007 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. 5/10 Gene Ontology MF GO:0046933 0.207351951945239 0.21751858128805 525 642 569 0.0229696841828599 383 0.322090678262504 -0.390899775939104 -1 0.284019031337003 524 569 869 383 804 464 508 630 858 897 556 625 M19040 GO_ARYLSULFATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYLSULFATASE_ACTIVITY.html Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. 4/10 Gene Ontology MF GO:0004065 0.000791787116144456 0.00115260149818497 590 510.454545454545 569 7.92069374774388e-05 15 3.9490755071868 3.9490755071868 1 15.4446278825607 590 526 875 214 580 913 760 319 15 569 254 626 M19169 GO_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. 43/97 Gene Ontology MF GO:0008080 0.00296084620630494 0.00395352468766407 325 527.181818181818 573 0.000269530777587024 196 0.99932619529265 -0.877163503557351 -1 3.19629255402967 322 793 573 785 638 196 360 385 649 768 330 627 M18225 GO_GDP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_BINDING.html Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. 42/79 Gene Ontology MF GO:0019003 0.0839184282471183 0.0904039273856544 305 562.181818181818 576 0.00793650793650794 302 1.08946412879821 1.19566978860286 1 1.51362399872624 302 535 506 640 767 673 343 576 584 704 554 628 M18927 GO_RETINOL_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. 9/32 Gene Ontology MF GO:0004745 0.0753922432263177 0.0848946911075273 400 583 576 0.00780792635471527 333 1.73424040391992 -1.48187060274341 -1 2.47246320233571 400 585 854 576 779 530 333 566 638 552 600 629 M18815 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. 20/49 Gene Ontology MF GO:0016684 6.19585174467361e-08 3.47572171042666e-07 605 524.636363636364 577 5.63259265378831e-09 131 1.39806717610235 -1.11981577580246 -1 12.019131531801 604 383 276 558 131 473 643 908 602 577 616 630 M18449 GO_ATPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_BINDING.html Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. 45/113 Gene Ontology MF GO:0051117 0.000380659536221818 0.000581738826119721 610 471.909090909091 578 3.46114015074757e-05 145 1.37129109702728 -1.37779414606789 -1 5.90504475938047 606 608 344 715 578 145 583 204 599 494 315 631 M19077 GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. 28/59 Gene Ontology MF GO:0016278 0.000397447203907605 0.000605383158269863 375 573.363636363636 578 3.6138093092589e-05 124 0.670507537705577 -0.670507537705577 -1 2.87189305394633 374 846 578 856 864 124 246 464 844 905 206 632 M18616 GO_METAL_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_CLUSTER_BINDING.html Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. 36/69 Gene Ontology MF GO:0051540 0.0839184282471183 0.0904039273856544 560 628.272727272727 580 0.00793650793650794 389 1.25429259153244 -1.00494589701805 -1 1.74262512486692 503 735 484 778 809 389 580 775 556 745 557 633 M18603 GO_SPECTRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECTRIN_BINDING.html Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. 14/40 Gene Ontology MF GO:0030507 0.0307749697413633 0.0364388316113954 440 591.636363636364 581 0.00283764486069905 436 1.24604071788374 1.18127536677311 1 2.3856419371327 437 671 436 713 678 668 492 535 581 538 759 634 M18791 GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. 21/46 Gene Ontology MF GO:0018024 0.00957430739788297 0.0119516455984428 885 618.727272727273 581 0.00087420272980504 254 0.565133789737079 -0.565133789737079 -1 1.44616028385423 433 883 581 842 812 254 405 508 836 884 368 635 M19090 GO_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. 196/476 Gene Ontology MF GO:0016887 0.0181948290078217 0.0220834336242691 485 631.909090909091 582 0.00166791570935815 288 1.62753158970771 -1.19337138213813 -1 3.58719496513199 482 900 495 706 917 288 582 657 571 802 551 636 M18880 GO_DRUG_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORTER_ACTIVITY.html Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 10/30 Gene Ontology MF GO:0090484 0.0839184282471183 0.0904039273856544 775 607.636363636364 584 0.00793650793650794 54 3.84365535658889 -3.73296295246194 -1 5.34010446398318 771 829 290 412 881 907 503 560 54 584 893 637 M18234 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells. 19/39 Gene Ontology MF GO:1901505 4.65242490306101e-06 1.01187491981469e-05 425 597.909090909091 585 4.22948612886603e-07 391 1.31553409059625 -1.14963012183853 -1 8.74599742563632 840 421 396 638 391 585 814 912 421 442 717 638 M18692 GO_N_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. 48/116 Gene Ontology MF GO:0016410 0.000370545860256278 0.000568170319059626 320 502.090909090909 585 3.36916623629625e-05 120 0.958883436620108 -0.840160509417327 -1 4.14221855328361 317 748 585 839 636 120 263 329 653 781 252 639 M18785 GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. 73/147 Gene Ontology MF GO:0008757 0.00270258000477338 0.00362974248816279 395 611.181818181818 586 0.000245991427083144 192 1.03697453375808 -0.876578506663023 -1 3.36792723414791 393 915 580 894 805 192 586 474 744 806 334 640 M19098 GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS.html Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 28/44 Gene Ontology MF GO:0016875 0.00113923373102083 0.00162747675860119 110 500.181818181818 586 0.000103620372042183 108 0.636172810927608 -0.636172810927608 -1 2.36116350912065 108 633 586 733 665 157 288 359 759 906 308 641 M19186 GO_PHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 36/92 Gene Ontology MF GO:0019208 8.2501931906398e-07 2.39459148875896e-06 715 502.727272727273 586 7.50017844048757e-08 55 1.58702302263884 -1.15716513249556 -1 11.8730342221632 711 306 352 271 297 695 663 829 55 586 765 642 M18263 GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). 17/47 Gene Ontology MF GO:0016303 5.94521006322565e-06 1.26027494427825e-05 500 606.818181818182 587 5.40475102675738e-07 387 1.68841010645507 -1.97797646590765 -1 11.010716133133 693 498 387 630 403 751 587 790 587 497 852 643 M17891 GO_BETA_2_MICROGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_2_MICROGLOBULIN_BINDING.html Interacting selectively and non-covalently with beta-2-microglobulin. 16/41 Gene Ontology MF GO:0030881 0.0515658897098228 0.0595987670013028 360 585.454545454545 588 0.00480143239259514 356 1.33690181151289 -1.0470463267709 -1 2.17938555506094 356 681 398 783 697 405 584 695 720 588 533 644 M17933 GO_STEROID_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_DEHYDROGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. 14/53 Gene Ontology MF GO:0016229 0.000212155877449482 0.000338860082037367 475 523 588 1.92887581232592e-05 179 1.30365444878439 -1.30365444878439 -1 6.02104894948605 473 682 430 666 617 323 588 179 690 746 359 645 M18119 GO_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. 45/90 Gene Ontology MF GO:0008170 0.000106587256416582 0.000178291410733191 270 546.545454545455 588 9.69022007150232e-06 86 0.801760982578535 -0.624607096707168 -1 4.00062599891015 269 903 588 887 842 86 261 391 754 809 222 646 M18940 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 201/490 Gene Ontology MF GO:0004674 1.25135233333783e-07 5.50657978498022e-07 670 554 588 1.13759309501302e-08 180 1.25644143356071 1.39883646166138 1 10.4673844732825 666 291 527 582 180 588 624 746 535 591 764 647 M18357 GO_IMMUNOGLOBULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. 2/121 Gene Ontology MF GO:0034987 0.000898577856375404 0.0012998296035619 450 557.5 588.5 9.98818803028572e-05 133 0.888632650572132 0.888632650572132 1 3.41364508229257 450 720 721 NA 796 457 133 241 829 859 369 648 M18734 GO_ENDONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. 61/143 Gene Ontology MF GO:0004519 0.000891648649118901 0.00129183741289668 590 639.818181818182 589 8.10918395364515e-05 402 1.00448645079588 -1.00617250962472 -1 3.86227396019119 589 858 546 891 581 402 733 417 700 790 531 649 M18172 GO_PROTEIN_C_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_C_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 126/295 Gene Ontology MF GO:0008022 7.06621135709787e-08 3.73107484368215e-07 625 562.727272727273 590 6.4238287127805e-09 144 1.37077037697903 -1.13127255722391 -1 11.7282870008691 621 590 438 487 144 508 719 804 483 711 685 650 M18634 GO_3_5_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_DNA_HELICASE_ACTIVITY.html Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. 7/13 Gene Ontology MF GO:0043138 0.0172570294737553 0.021028433266033 405 600.181818181818 591 0.00173925250096724 274 0.687522786864345 -0.687522786864345 -1 1.53480305920349 401 669 784 591 825 290 274 545 890 876 457 651 M18638 GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. 9/21 Gene Ontology MF GO:0034236 0.0098893715042387 0.0123115315073066 440 611.727272727273 591 0.000993365899238461 440 1.26041775669078 1.36036572466762 1 3.20375712542789 440 642 787 665 660 591 520 847 561 548 468 652 M18722 GO_RNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. 34/69 Gene Ontology MF GO:0003724 0.00541138919662756 0.00694348404588194 320 607.818181818182 591 0.000493158702640202 223 0.891231954112397 -0.891231954112397 -1 2.56041198612113 316 859 591 773 883 223 466 513 849 803 410 653 M18197 GO_PHOSPHATASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVATOR_ACTIVITY.html Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 5/11 Gene Ontology MF GO:0019211 2.57521553394336e-05 4.74789236719016e-05 470 627.181818181818 592 2.5752453772378e-06 324 1.05839001485011 -0.940334697263148 -1 6.09065301046844 788 324 685 367 467 901 567 861 469 592 878 654 M18406 GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 434/1422 Gene Ontology MF GO:0001071 1.08138340347784e-07 5.0246097535334e-07 640 559.454545454545 592 9.83075869665397e-09 169 1.42958186782127 -1.24296690389049 -1 11.9855059813183 638 488 331 883 169 614 592 789 503 376 771 655 M18939 GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. 6/28 Gene Ontology MF GO:0030898 0.0765897756730953 0.0848946911075273 480 558.909090909091 592 0.00793650793650794 182 5.81869432397637 5.81869432397637 1 8.29556987259073 478 592 858 359 900 601 442 480 182 632 624 656 M19226 GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. 22/59 Gene Ontology MF GO:0005544 9.98538820779133e-07 2.77539490971844e-06 855 499.090909090909 592 9.07762976361366e-08 81 1.34549989463319 -1.17835981297016 -1 9.95133763912039 852 185 171 433 307 786 653 621 592 81 809 657 M18370 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. 5/13 Gene Ontology MF GO:0016671 0.0623776968525882 0.0715554627236673 495 589.363636363636 593 0.00642010975639125 361 1.11540984327448 -1.11540984327448 -1 1.70042685202116 495 660 725 617 791 361 505 472 818 593 446 658 M18589 GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY.html Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 5/17 Gene Ontology MF GO:0003906 0.00645097079700254 0.00823147452599492 595 582.727272727273 593 0.000646977442788082 314 0.717995246602035 -0.717995246602035 -1 1.99209800760925 536 670 774 511 813 395 593 423 786 595 314 659 M18104 GO_HYDRO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDRO_LYASE_ACTIVITY.html Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. 34/52 Gene Ontology MF GO:0016836 4.64881130393788e-07 1.47733098636399e-06 665 532.363636363636 594 4.22619298752422e-08 162 1.10313707014394 -0.904660184965474 -1 8.56090551585658 664 162 374 730 266 478 851 651 709 377 594 660 M18240 GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other. 11/17 Gene Ontology MF GO:0042887 0.0013093563760045 0.00184190805187178 840 645.545454545455 594 0.000119103300462262 228 1.54624621818305 -0.831180607308222 -1 5.6282861857788 839 543 228 575 594 771 906 766 570 459 850 661 M18339 GO_EXORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXORIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. 21/34 Gene Ontology MF GO:0004532 0.00858923192265045 0.0107657947804338 395 572.545454545455 595 0.000783904583274308 246 0.760854350280883 -0.760854350280883 -1 1.99296202417926 391 595 510 711 734 246 460 611 825 777 438 662 M18531 GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. 32/69 Gene Ontology MF GO:0034212 0.00039476782973589 0.000602299176379799 245 516.090909090909 595 3.58944258768385e-05 123 0.774609385392801 -0.774609385392801 -1 3.32006527874385 242 868 595 729 775 123 258 349 707 799 232 663 M18579 GO_CHAPERONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_BINDING.html Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. 67/131 Gene Ontology MF GO:0051087 0.00447913263354554 0.00582857428976223 380 584.818181818182 596 0.000408025280807731 210 1.45577819407142 -1.07294068491519 -1 4.32958396441799 376 877 529 830 742 210 410 667 596 761 435 664 M18701 GO_QUATERNARY_AMMONIUM_GROUP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_BINDING.html Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 10/56 Gene Ontology MF GO:0050997 3.9375587688569e-06 8.83549772523987e-06 845 593.727272727273 596 3.57960528755912e-07 313 1.19092968028826 -1.0864522290477 -1 8.01095463352036 844 462 313 596 381 798 744 565 651 422 755 665 M18976 GO_MHC_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 28/83 Gene Ontology MF GO:0042287 0.00529909476013399 0.00682796523714744 890 593.818181818182 596 0.000482900162619531 243 1.75012886687249 -0.821499261564798 -1 5.04490275546435 903 536 243 423 640 596 890 603 468 343 887 666 M19228 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. 28/59 Gene Ontology MF GO:0042054 0.00091332989657269 0.00131702743706407 275 552.727272727273 597 8.30644805417738e-05 151 0.539620491082855 -0.539620491082855 -1 2.06882901758882 274 818 597 824 740 151 273 379 802 920 302 667 M18614 GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Increases the activity of a peptidase that is involved in the apoptotic process. 14/28 Gene Ontology MF GO:0016505 0.000569892756091529 0.00084838403819451 660 591.090909090909 598 5.18218578093898e-05 378 0.792949626663462 -0.757011311699859 -1 3.24164695439956 657 598 482 645 566 378 487 777 757 748 407 668 M18995 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS.html Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). 105/227 Gene Ontology MF GO:0016741 0.000287825487680582 0.000450339198411795 210 565.363636363636 598 2.61693773382468e-05 109 1.01404267702446 -0.847090909736476 -1 4.51673511534276 210 892 598 888 869 109 391 431 715 815 301 669 M19125 GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a chloride channel. 6/19 Gene Ontology MF GO:0017081 0.0121927746677258 0.0150770869547147 600 636.909090909091 598 0.00122601945652795 443 0.476894268673078 -0.476894268673078 -1 1.15631774548315 598 443 899 457 666 550 512 479 812 910 680 670 M19057 GO_NEUROPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_BINDING.html Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). 2/38 Gene Ontology MF GO:0042923 0.00224929506361851 0.00303869524013074 465 605.3 598.5 0.000250171871517093 141 0.811802877392739 0.811802877392739 1 2.72000951175086 465 623 882 NA 717 484 141 490 776 901 574 671 M18932 GO_NUCLEOSOMAL_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOMAL_DNA_BINDING.html Interacting selectively and non-covalently with the DNA portion of a nucleosome. 24/61 Gene Ontology MF GO:0031492 1.56142557813552e-05 3.02264923341231e-05 830 551.909090909091 599 1.41948787299122e-06 192 2.37487276570649 -1.49724511108287 -1 14.2864498274682 826 694 233 317 444 724 817 599 192 357 868 672 M18389 GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group (CH3-) to a protein. 43/84 Gene Ontology MF GO:0008276 1.72911189079351e-05 3.30724103852397e-05 205 513.090909090909 601 1.57193225551819e-06 46 0.714028710764435 -0.714028710764435 -1 4.25822081185934 203 881 601 877 904 46 158 291 761 807 115 673 M18596 GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING.html Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. 46/115 Gene Ontology MF GO:0008135 0.00720832098632303 0.0091345114427234 390 562.272727272727 602 0.000657458911729597 237 0.895372073649499 -0.733097729846883 -1 2.43035888629085 388 775 602 762 702 237 389 426 695 778 431 674 M17926 GO_UBIQUITIN_LIKE_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_BINDING.html Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. 76/151 Gene Ontology MF GO:0032182 0.000728190506561272 0.00106847729830362 895 614.090909090909 603 6.62210587478837e-05 143 0.859089063636068 -0.753973819204232 -1 3.39748720322605 549 893 594 892 674 143 603 563 760 800 284 675 M17942 GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY.html Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 51/102 Gene Ontology MF GO:0070035 0.00407807614950766 0.00533914030458463 225 589.727272727273 603 0.000371423203364013 206 0.719177171118078 -0.719177171118078 -1 2.17534357220887 223 880 603 719 896 206 432 477 835 813 403 676 M18560 GO_MYOSIN_HEAVY_CHAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_HEAVY_CHAIN_BINDING.html Interacting selectively and non-covalently with a heavy chain of a myosin complex. 11/27 Gene Ontology MF GO:0032036 7.65846725383535e-06 1.58407502531527e-05 800 566.636363636364 603 6.96226719456376e-07 283 1.33397804905603 -1.50189034514302 -1 8.52300968541664 796 513 336 603 414 712 842 283 644 462 628 677 M19179 GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_.html Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. 9/15 Gene Ontology MF GO:0031078 0.00146562692575484 0.00203375078686946 700 601.454545454545 603 0.000146659445199132 322 0.70327503706524 -0.579598567571384 -1 2.51961885870582 542 322 908 343 603 636 590 571 706 698 697 678 M18451 GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. 20/54 Gene Ontology MF GO:0052742 2.75413087515439e-07 9.82093180287614e-07 870 643.363636363636 604 2.50375565448904e-08 236 1.53656193848119 -1.62837406613365 -1 12.2871666260662 867 542 429 604 236 870 747 897 576 576 733 679 M18804 GO_RETINOID_X_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOID_X_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a retinoid X receptor. 8/25 Gene Ontology MF GO:0046965 0.00352212338440084 0.00464900073694229 825 602.454545454545 604 0.000352771827775482 353 1.1111926353048 1.33717844555136 1 3.45000581943379 513 604 821 572 633 619 527 553 823 353 609 680 M18081 GO_ADRENERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_ACTIVITY.html Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. 4/26 Gene Ontology MF GO:0004935 0.000225766120973371 0.000358730278575996 535 579.363636363636 605 2.25789060907131e-05 185 1.94080343163943 1.94080343163943 1 8.89985218935657 532 718 661 605 788 791 626 185 415 557 495 681 M17877 GO_LONG_CHAIN_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 12/26 Gene Ontology MF GO:0036041 0.00210951717463855 0.00285405264804039 785 522.727272727273 606 0.00019195842272514 147 2.37647531808287 2.18290689248492 1 8.04868666739635 785 296 147 184 613 831 556 718 606 241 773 682 M18177 GO_R_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_R_SMAD_BINDING.html Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. 15/30 Gene Ontology MF GO:0070412 0.036579666326921 0.0430900038678198 425 562.636363636364 606 0.00338203878380895 277 1.69863672872973 1.69863672872973 1 3.08755104952884 425 798 447 701 686 639 277 606 611 579 420 683 M18246 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. 6/14 Gene Ontology MF GO:0004861 0.0020660366571288 0.00280347157014527 610 558.090909090909 606 0.000206796000264496 269 1.52348428660902 1.90262610154629 1 5.17550921890792 545 606 695 606 615 665 459 269 563 432 684 684 M19209 GO_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY.html Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 210/431 Gene Ontology MF GO:0016874 2.69387613226537e-08 2.15926568991322e-07 170 473.818181818182 606 2.44897833204691e-09 5 0.956720317906223 -1.00880971700634 -1 8.48815176721963 167 832 606 900 811 5 197 145 722 816 11 685 M17871 GO_MHC_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the major histocompatibility complex. 15/33 Gene Ontology MF GO:0023023 0.00995815874031471 0.0123804135690399 640 561.727272727273 607 0.000909411039263404 303 1.69297230893347 -2.01690404885241 -1 4.29777397314492 639 695 303 607 738 444 722 334 728 578 391 686 M18422 GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME.html The action of a molecule that contributes to the structural integrity of the ribosome. 129/311 Gene Ontology MF GO:0003735 0.000640901312495036 0.000947956925233815 170 518.454545454545 607 5.82807359332337e-05 135 0.69644093988255 -0.670098300585891 -1 2.80243441392236 170 791 607 789 684 135 280 397 748 817 285 687 M18281 GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within. 4/13 Gene Ontology MF GO:0044213 0.00114624137401741 0.00163494893658297 575 626.363636363636 608 0.000114683304476702 247 1.6782055879858 -2.60423267449612 -1 6.22423965643817 794 571 704 571 746 853 608 247 439 560 797 688 M18505 GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the class II major histocompatibility complex. 15/28 Gene Ontology MF GO:0023026 0.0101785983149952 0.0126203644875952 640 562.909090909091 608 0.000929636208117997 304 1.69297230893347 -2.01690404885241 -1 4.27898819358688 640 696 304 608 739 445 723 336 729 580 392 689 M18898 GO_CULLIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). 7/16 Gene Ontology MF GO:0097602 0.0765897756730953 0.0848946911075273 610 607.727272727273 608 0.00793650793650794 340 0.83859070613337 -0.649293115132725 -1 1.19555719936123 469 507 843 526 800 607 340 638 686 661 608 690 M17852 GO_5_3_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_5_3_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. 4/12 Gene Ontology MF GO:0008409 0.00134430488690046 0.00188818396328004 320 517.636363636364 609 0.000134511879997892 174 0.858418740546181 -0.858418740546181 -1 3.11230318164544 320 631 609 627 657 174 229 590 804 818 235 691 M18999 GO_PROTEIN_N_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 62/154 Gene Ontology MF GO:0047485 0.00181540182416762 0.00248907552642953 740 645.636363636364 609 0.000165172872286918 417 1.32416094865263 -0.844549959606336 -1 4.58942339979809 736 509 530 566 609 574 854 672 417 749 886 692 M18148 GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. 7/17 Gene Ontology MF GO:0017110 3.75260715625181e-06 8.50344478756569e-06 675 609 610 3.75261349319409e-07 383 1.05433632384155 -0.834591382437765 -1 7.11548631865223 704 479 675 675 383 610 599 862 574 475 663 693 M18434 GO_BETA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. 28/46 Gene Ontology MF GO:0048487 7.7758152506928e-05 0.00013346548564622 610 604.090909090909 610 7.06917281589782e-06 380 1.40124465888514 -0.914872927129145 -1 7.22648462995416 705 656 380 547 497 750 717 610 404 609 770 694 M18619 GO_OXYGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_BINDING.html Interacting selectively and non-covalently with oxygen (O2). 12/94 Gene Ontology MF GO:0019825 0.0020272121193157 0.0027548525107392 750 575 610 0.000184462047969042 200 1.42492057456307 1.84980554691215 1 4.85508305153087 489 539 200 763 610 746 516 673 679 362 748 695 M18974 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/73 Gene Ontology MF GO:0016903 4.73244421141458e-08 2.97592386690275e-07 800 582.727272727273 612 4.30222210292246e-09 113 1.42242144821978 -1.23290125892023 -1 12.3561541887654 799 650 264 612 113 560 904 703 589 507 709 696 M19144 GO_RNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. 22/44 Gene Ontology MF GO:0034062 0.125407397037544 0.133690388498888 485 690.363636363636 612 0.0121076595554075 417 0.74842186540508 -0.74842186540508 -1 0.870543254883975 483 906 590 833 889 417 612 522 837 912 593 697 M17922 GO_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. 21/35 Gene Ontology MF GO:0034061 0.0784901898239516 0.0868964797088273 415 621.090909090909 613 0.00740353562901394 412 1.15610743988496 -1.28497175267305 -1 1.6326579340228 412 887 502 852 748 486 613 449 731 680 472 698 M17994 GO_CYCLIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_BINDING.html Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. 8/22 Gene Ontology MF GO:0030332 8.83157068549992e-05 0.000150463796864073 735 611.909090909091 613 8.83192169001638e-06 346 1.19054372522309 -0.752908231665495 -1 6.05735902767606 733 587 632 493 504 861 674 613 605 346 683 699 M18105 GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY.html Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. 26/75 Gene Ontology MF GO:0003743 0.049851041557868 0.0576892556392938 755 640 614 0.00463798466083278 383 0.777555261149064 -0.675069149142994 -1 1.28218804477312 527 847 600 753 696 383 565 614 755 762 538 700 M18152 GO_RNA_POLYMERASE_II_CORE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_BINDING.html Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. 9/22 Gene Ontology MF GO:0000993 0.000553511352281923 0.000828016982275397 545 625.272727272727 615 5.53649269299876e-05 406 0.86520661779279 -0.956307608839714 -1 3.54919306395119 575 406 676 545 569 783 542 739 615 690 738 701 M18775 GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. 37/81 Gene Ontology MF GO:0033613 0.00115238060629274 0.00164116123496799 520 620.454545454545 616 0.000104816788825421 426 1.620218567591 1.86518498266202 1 6.00562159119259 518 769 426 673 589 728 478 747 616 524 757 702 M17920 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 4/10 Gene Ontology MF GO:0016888 0.00780074141406398 0.00981762257310377 425 572.272727272727 618 0.000782826067472844 252 0.393241304405752 -0.393241304405752 -1 1.05100264530226 422 744 618 684 908 303 252 327 843 821 373 703 M18293 GO_MANNOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSE_BINDING.html Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. 7/23 Gene Ontology MF GO:0005537 0.000503753841375329 0.000757277016446573 335 547.454545454545 618 5.03868073391779e-05 215 2.7266295139714 -2.7266295139714 -1 11.3257568262641 334 729 705 618 786 433 420 215 641 654 487 704 M18587 GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any complex of RNA and protein. 64/123 Gene Ontology MF GO:0043021 0.0758492426564685 0.0848946911075273 445 660.909090909091 620 0.00714526518732999 371 0.69426705200341 -0.657082327582313 -1 0.989798473840303 445 867 604 774 783 371 561 620 850 814 581 705 M18023 GO_CYTOSKELETAL_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. 6/18 Gene Ontology MF GO:0008093 3.40593772453439e-05 6.13202095219498e-05 755 588.090909090909 621 3.40598992751349e-06 292 0.893859858267568 -1.18267722452022 -1 5.01165761869309 753 338 641 292 477 841 640 554 402 621 910 706 M18814 GO_1_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 10/24 Gene Ontology MF GO:0005545 0.00144863043700193 0.00201320242000268 870 667.818181818182 621 0.000131780472236766 252 2.22522810453052 -1.4804809067741 -1 7.98537513663885 868 621 252 595 599 772 903 819 475 583 859 707 M19003 GO_GLUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 10/16 Gene Ontology MF GO:0046527 6.20494909223991e-06 1.30332264037916e-05 410 549.636363636364 623 5.64087872085663e-07 95 1.36959832903285 -0.659563832626729 -1 8.90504138962942 818 683 409 349 406 656 745 623 95 585 677 708 M18283 GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES.html Catalysis of the hydrolysis of any acid anhydride. 387/890 Gene Ontology MF GO:0016817 0.0097983392596765 0.0122147318684314 555 644.272727272727 624 0.000894750279269329 255 1.45395982646598 -1.16816216191806 -1 3.70234101357059 582 899 555 860 836 255 633 624 552 798 493 709 M18676 GO_VITAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BINDING.html Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 36/91 Gene Ontology MF GO:0019842 2.93025820806453e-07 1.03288795073539e-06 910 597.818181818182 627 2.66387145305101e-08 239 1.79940117862501 -1.80388871269039 -1 14.336516831677 906 845 265 776 239 561 865 568 627 286 638 710 M18013 GO_LEUCINE_ZIPPER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUCINE_ZIPPER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. 8/14 Gene Ontology MF GO:0043522 0.0174550792001184 0.0212416307726308 675 575.181818181818 629 0.00175937202412548 378 1.5035527517527 1.5035527517527 1 3.34771532967079 378 741 638 683 671 597 385 404 629 673 528 711 M18344 GO_NUCLEOTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDASE_ACTIVITY.html Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. 7/15 Gene Ontology MF GO:0008252 0.000299282531734848 0.000467470168414363 630 586.181818181818 629 2.99322845891639e-05 153 2.08185877432816 -0.519449071481743 -1 9.22805915617785 629 612 720 399 551 884 835 306 153 655 704 712 M17896 GO_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVITY.html Catalysis of the reaction: GTP + H2O = GDP + phosphate. 129/266 Gene Ontology MF GO:0003924 0.00355294677948009 0.00468296710189353 875 685.454545454545 633 0.000323517973585878 485 1.33521937890034 -1.257850878079 -1 4.13994064447785 872 733 505 880 627 485 915 725 557 608 633 713 M18321 GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. 25/81 Gene Ontology MF GO:0004715 0.0163547668142477 0.0200084913153031 635 609.090909090909 633 0.00149796622860054 280 1.08225826452893 -0.852789264508988 -1 2.44710226079238 633 609 395 798 888 280 481 728 721 717 450 714 M18239 GO_ANDROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an androgen receptor. 29/64 Gene Ontology MF GO:0050681 0.0177833868362683 0.0216125705275652 885 659.272727272727 634 0.00162988949260051 434 1.44769640187727 -0.822093885630867 -1 3.20886150766436 885 679 434 530 670 586 789 615 525 634 905 715 M19001 GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. 10/30 Gene Ontology MF GO:0005242 7.25859739979292e-06 1.51096376700201e-05 585 606.727272727273 635 6.59874668058844e-07 257 1.56511498698658 1.41938592663443 1 10.0425332008405 741 706 257 584 410 866 635 768 585 297 825 716 M18087 GO_HISTONE_DEACETYLASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone deacetylase. 67/158 Gene Ontology MF GO:0042826 5.78958271018173e-07 1.76957345294591e-06 740 619.636363636364 636 5.26325839435035e-08 281 1.21826046590459 -0.971350229328916 -1 9.32720939889929 737 636 383 503 281 736 622 899 699 471 849 717 M17889 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. 11/26 Gene Ontology MF GO:0080025 0.00728503621614124 0.00919373569115218 640 650 637 0.000664479288274773 320 1.78398822220325 -0.455000889246181 -1 4.83571643564381 637 863 442 579 851 828 895 320 452 719 564 718 M18277 GO_GAMMA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. 13/46 Gene Ontology MF GO:0043015 0.000355369174665019 0.000547637589098522 600 643.545454545455 639 3.23115082677617e-05 465 1.21147804883788 1.21147804883788 1 5.25916220245647 596 567 465 501 554 834 784 720 674 639 745 719 M17940 GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. 19/38 Gene Ontology MF GO:0004003 0.248468404071646 0.259762422438539 565 687.181818181818 640 0.025633202075743 480 0.547122388123759 -0.547122388123759 -1 0.426320671681422 551 870 562 754 795 480 563 627 891 826 640 720 M19069 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC.html Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 8/18 Gene Ontology MF GO:0000983 2.78434917082252e-06 6.5180693057423e-06 145 576 640 2.78435265949881e-07 110 1.64889920593876 -1.10299849696712 -1 11.3814984852791 894 145 888 144 370 640 916 889 110 523 817 721 M18051 GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. 2/11 Gene Ontology MF GO:0019203 0.0460732492366634 0.0535870914004176 580 644.6 641 0.00522722268059461 455 0.807175132589405 -0.807175132589405 -1 1.36544815159196 577 676 652 NA 701 471 455 567 880 837 630 722 M18025 GO_RACEMASE_AND_EPIMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RACEMASE_AND_EPIMERASE_ACTIVITY.html Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. 4/18 Gene Ontology MF GO:0016854 0.00150964775556542 0.00209168062518101 810 636.545454545455 642 0.000151067430355005 332 1.02580473333898 -0.95462968477282 -1 3.6584902453974 808 452 642 440 606 492 809 760 857 332 804 723 M17938 GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 3/14 Gene Ontology MF GO:0099528 0.0240466846682834 0.0288434809580453 645 630.636363636364 643 0.00243109273238842 251 0.43787021339319 0.521274366812639 1 0.897500993306175 597 645 623 643 835 545 251 677 797 825 499 724 M18186 GO_PHOSPHATE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_BINDING.html Interacting selectively and non-covalently with phosphate. 8/18 Gene Ontology MF GO:0042301 0.00155112330443372 0.00214269285297151 625 616.090909090909 643 0.000155220706182224 240 0.964304690516071 -0.964304690516071 -1 3.42572152487613 625 643 682 781 669 518 877 438 793 511 240 725 M18271 GO_DIPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a dipeptide. 4/14 Gene Ontology MF GO:0016805 3.25176556725431e-05 5.90063968811432e-05 745 633.181818181818 643 3.25181315114114e-06 425 1.22891061371884 -0.77760382839912 -1 6.91753078012806 745 425 702 496 475 643 839 883 463 559 735 726 M18808 GO_POTASSIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_BINDING.html Interacting selectively and non-covalently with potassium (K+) ions. 9/25 Gene Ontology MF GO:0030955 0.00585947121714745 0.00749751532653081 645 637.272727272727 645 0.00058749788281991 246 2.19183138006237 -3.29506164215868 -1 6.19962916477564 880 641 823 246 645 820 759 468 443 551 734 727 M18187 GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. 6/18 Gene Ontology MF GO:0004550 0.114760564837936 0.122482273376916 425 634.727272727273 646 0.012115718652462 418 0.350990431331477 -0.350990431331477 -1 0.426026741798865 423 715 683 646 744 418 489 612 832 845 575 728 M18539 GO_CAMP_RESPONSE_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_RESPONSE_ELEMENT_BINDING.html Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. 8/16 Gene Ontology MF GO:0035497 0.000118276239139476 0.000197484827601302 520 680.181818181818 646 1.18282534782012e-05 500 1.08583938154939 -0.929881155010699 -1 5.35394578346355 877 646 766 500 517 862 736 852 591 518 617 729 M18573 GO_ACETYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_BINDING.html Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. 3/20 Gene Ontology MF GO:0042166 0.000916244199014733 0.00131916222706346 725 637.545454545455 647 9.16622194924155e-05 235 1.51790848413138 -1.51790848413138 -1 5.81802856172174 724 647 772 577 789 733 885 235 508 502 641 730 M19212 GO_MRNA_3_UTR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_UTR_BINDING.html Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. 25/64 Gene Ontology MF GO:0003730 0.00425028927725812 0.00554647678734393 650 675.181818181818 647 0.000387138445507216 393 1.8948061842 -1.73001761242842 -1 5.68962075889131 647 725 393 570 635 902 703 891 492 573 896 731 M18043 GO_DNA_N_GLYCOSYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_N_GLYCOSYLASE_ACTIVITY.html Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. 7/17 Gene Ontology MF GO:0019104 0.0187762721622281 0.0227591177723977 835 591 648 0.00189368315742663 296 0.650665951037491 -0.650665951037491 -1 1.4227776345702 390 770 648 699 832 296 357 434 841 835 399 732 M18280 GO_POLY_PURINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PURINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. 15/29 Gene Ontology MF GO:0070717 4.09971550189201e-05 7.28134799563832e-05 685 623 651 3.72708354761136e-06 135 2.04800907337482 2.63992290709181 1 11.2793200805835 605 849 372 651 878 822 681 135 612 682 566 733 M18345 GO_ION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ion A(out) + ion B(in) = ion A(in) + ion B(out) where ion A and ion B are different types of ion. 12/57 Gene Ontology MF GO:0099516 0.00531876975370988 0.00684373171106726 655 652.545454545455 651 0.000484697474868311 317 1.5807359010424 1.95918226596819 1 4.55450478295495 917 653 317 512 641 651 778 803 624 492 790 734 M18871 GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. 4/12 Gene Ontology MF GO:0010857 0.00725368199584892 0.00916674098376512 850 639.636363636364 651 0.000727746850007781 323 1.15421096682164 -1.7620852847623 -1 3.13059028981633 850 389 835 323 651 865 896 527 460 567 673 735 M18893 GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. 7/18 Gene Ontology MF GO:0042975 0.000105484429279718 0.000176768078210092 800 539.272727272727 653 1.05489436748423e-05 27 1.84442289319619 2.07419885323546 1 9.21244928950718 798 352 841 121 515 653 731 683 27 482 729 736 M18057 GO_C2H2_ZINC_FINGER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_C2H2_ZINC_FINGER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. 7/22 Gene Ontology MF GO:0070742 0.0765897756730953 0.0848946911075273 655 660 654 0.00793650793650794 427 2.4707784994545 2.4707784994545 1 3.52252766161233 580 758 654 697 794 693 427 704 652 652 649 737 M18301 GO_FOLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_BINDING.html Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 7/12 Gene Ontology MF GO:0005542 0.00807031920249914 0.0101291864478843 590 641.363636363636 654 0.000809977840974241 430 2.15299742448331 -2.15299742448331 -1 5.71536612646514 588 800 707 826 654 587 641 430 683 478 661 738 M18036 GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY.html Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. 6/15 Gene Ontology MF GO:0034450 0.00724154396870049 0.00916398961651231 685 654.090909090909 655 0.000726525074939682 323 0.912818155772397 -0.912818155772397 -1 2.47601372328379 684 686 646 586 817 625 616 323 655 833 724 739 M18364 GO_DIACYLGLYCEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_BINDING.html Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. 6/14 Gene Ontology MF GO:0019992 0.147859119791321 0.156356770354041 595 630.272727272727 655 0.0158730158730159 361 1.25658508079921 1.25658508079921 1 1.347865353724 594 532 723 361 773 714 418 756 782 625 655 740 M18495 GO_GLYCOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BINDING.html Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. 13/28 Gene Ontology MF GO:0051861 0.00898119120826114 0.0112417631450343 805 631.727272727273 655 0.000819824235240817 238 2.40170975242996 -2.35313255751147 -1 6.23091752011907 803 704 238 488 655 802 615 820 593 389 842 741 M18820 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. 19/45 Gene Ontology MF GO:0015932 0.00121819108936202 0.00172686564285525 455 649 655 0.000110806013948515 453 1.0253390373554 -1.04162780750384 -1 3.7704260890724 835 574 455 779 591 662 887 655 714 534 453 742 M19082 GO_MONOSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 36/85 Gene Ontology MF GO:0048029 0.0839184282471183 0.0904039273856544 660 651.181818181818 656 0.00793650793650794 309 1.59508432020608 -1.26375998232325 -1 2.21609729315092 656 708 309 613 841 856 650 784 482 416 848 743 M18453 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 46/107 Gene Ontology MF GO:0004197 6.98325366882855e-08 3.73107484368215e-07 810 580.181818181818 659 6.34841262771947e-09 142 1.95983656195031 -1.75215448644811 -1 16.7683273275483 810 693 235 851 142 647 680 659 423 443 799 744 M18864 GO_TRANSLATION_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY.html Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 16/42 Gene Ontology MF GO:0045182 0.0105038394009049 0.0130060999311339 860 616.272727272727 659 0.00095948431749542 361 1.84514177850161 -1.74838289627894 -1 4.63148519997032 860 726 456 680 659 575 774 415 361 688 585 745 M19024 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. 25/65 Gene Ontology MF GO:0016860 0.0697103388638244 0.0791771750058252 600 628.090909090909 659 0.00654749636997905 362 1.1280442807302 -0.788483976081468 -1 1.6536886284354 600 785 523 871 708 362 659 445 719 757 480 746 M18886 GO_TRANSLATION_REPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REPRESSOR_ACTIVITY.html Antagonizes ribosome-mediated translation of mRNA into a polypeptide. 7/22 Gene Ontology MF GO:0030371 0.00330949799424028 0.00438091820820296 630 709.636363636364 660 0.000331443709946524 588 2.03865954294696 2.03865954294696 1 6.3995780611166 591 588 840 628 629 889 795 825 634 660 727 747 M18533 GO_GLUCOCORTICOID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glucocorticoid receptor. 9/19 Gene Ontology MF GO:0035259 2.38201058516895e-05 4.40935561037311e-05 790 636.636363636364 661 2.38203611843907e-06 360 1.06097618993109 0.869737995973615 1 6.1509026796899 790 360 764 510 464 661 900 711 803 393 647 748 M18891 GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. 24/52 Gene Ontology MF GO:0001102 1.62937285080825e-06 4.10691239107832e-06 895 644.181818181818 662 1.48124914323834e-07 341 1.37867609958631 -1.25276894498446 -1 9.88440305931084 892 662 432 647 341 713 820 642 693 542 702 749 M18482 GO_TELOMERIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERIC_DNA_BINDING.html Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. 18/38 Gene Ontology MF GO:0042162 0.110806994846539 0.118537715417228 665 695.363636363636 663 0.0106196601988976 438 0.420905835526385 -0.420905835526385 -1 0.518853851237934 663 860 560 788 840 438 648 607 887 868 490 750 M18766 GO_SINGLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with single-stranded DNA. 52/108 Gene Ontology MF GO:0003697 0.0127388178135713 0.0157311575684371 405 660 664 0.00116483489607988 405 0.891740777573773 -0.74471479055238 -1 2.14029968013536 405 844 572 831 664 451 585 731 763 788 626 751 M18771 GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY.html Modulation of the activity of the enzyme protein phosphatase type 2A. 9/22 Gene Ontology MF GO:0008601 0.00635982834542395 0.00812644733026393 915 599.909090909091 664 0.000637810333561777 19 1.2780289226475 -0.457351192113128 -1 3.55541486918884 911 505 814 260 649 558 688 664 19 693 838 752 M18827 GO_SNRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_BINDING.html Interacting selectively and non-covalently with a small nuclear RNA (snRNA). 18/42 Gene Ontology MF GO:0017069 0.0839184282471183 0.0904039273856544 655 656.818181818182 665 0.00793650793650794 454 1.64427810646647 -1.13725443146565 -1 2.28444369562218 651 665 454 537 774 557 751 855 510 715 756 753 M18764 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES.html Catalysis of the transfer of a phosphate group from one position to another within a single molecule. 6/10 Gene Ontology MF GO:0016868 0.0139741181532644 0.0172104266412359 830 619.545454545455 668 0.00140627780202145 51 2.25859842767595 -0.537338619365407 -1 5.30361064040288 829 714 810 462 668 745 841 457 51 626 612 754 M18133 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY.html Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. 8/13 Gene Ontology MF GO:0034595 0.0170249804828133 0.0207731857349977 500 640.636363636364 669 0.00171568369445973 365 1.03069475295945 -1.03069475295945 -1 2.30816550289491 499 753 669 793 915 421 591 365 846 674 521 755 M18741 GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the directed movement of water (H2O) from one side of a membrane to the other. 7/14 Gene Ontology MF GO:0005372 0.000273898717768247 0.000430011638817043 785 570.636363636364 669 2.73932482854014e-05 174 3.17665017885021 -2.73855951176499 -1 14.2342097016892 783 174 805 362 549 706 826 669 394 310 699 756 M17917 GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 87/194 Gene Ontology MF GO:0008234 1.76690432900498e-05 3.36553205524757e-05 735 610.454545454545 672 1.60628956350044e-06 227 1.5920162188154 -1.35544190801064 -1 9.478158064725 735 724 439 890 451 227 805 833 544 672 395 757 M18718 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase. 162/400 Gene Ontology MF GO:0044389 0.00383727731277103 0.00504327875392764 770 613.090909090909 672 0.00034945334058725 221 1.41020026532697 -1.08348539068421 -1 4.31200012660637 770 790 462 726 632 221 672 799 453 683 536 758 M18340 GO_LYSOZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOZYME_ACTIVITY.html Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3/15 Gene Ontology MF GO:0003796 0.0765897756730953 0.0848946911075273 615 660.090909090909 673 0.00793650793650794 465 3.36008767357868 -3.36008767357868 -1 4.79039413412475 611 687 718 465 820 676 824 656 673 499 632 759 M18612 GO_TRANSLATION_INITIATION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_BINDING.html Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. 15/32 Gene Ontology MF GO:0031369 0.0033687151785341 0.00445289937392439 630 691.727272727273 673 0.00030671677776986 504 0.735076172794483 -0.717519829672682 -1 2.30055991147615 673 825 538 725 626 504 600 853 762 874 629 760 M18858 GO_GTP_RHO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_RHO_BINDING.html Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. 12/21 Gene Ontology MF GO:0017049 0.157683950412117 0.166554804109239 680 682.363636363636 676 0.0154789484289659 451 1.11053488542976 1.27572319370501 1 1.15064489889305 676 705 451 634 726 799 658 639 794 618 806 761 M18931 GO_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVITY.html Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. 8/35 Gene Ontology MF GO:0004629 0.0258953935021259 0.0309399506778647 855 655.181818181818 676 0.00262021944061638 260 1.93951595797508 -2.53204610565318 -1 3.89675885270288 634 713 855 561 854 687 260 676 610 521 836 762 M18218 GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. 8/12 Gene Ontology MF GO:0052743 0.0765897756730953 0.0848946911075273 695 684.818181818182 677 0.00793650793650794 591 1.03270581777863 -1.05008595272413 -1 1.47230239554725 695 605 691 677 852 592 808 591 734 675 613 763 M18901 GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING.html Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. 8/17 Gene Ontology MF GO:0043560 0.00744618701063825 0.00938423568463999 710 633.545454545455 677 0.000747125587984257 325 1.37280723926734 -1.37280723926734 -1 3.70488533051302 710 684 844 370 699 641 862 325 609 677 548 764 M18731 GO_GUANYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. 186/417 Gene Ontology MF GO:0019001 9.65868306255334e-06 1.92337411635261e-05 680 675.090909090909 678 8.7806595158468e-07 428 1.32333408092574 -1.11092946561624 -1 8.30654059337765 678 572 515 866 428 615 715 909 499 738 891 765 M18327 GO_HISTONE_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a histone. 14/27 Gene Ontology MF GO:0032452 0.111306983139484 0.118934290927207 860 693.090909090909 679 0.0106702479548908 407 0.449273527812808 -0.449273527812808 -1 0.552955598163614 627 862 558 787 839 407 660 679 856 857 492 766 M18644 GO_GABA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. 7/25 Gene Ontology MF GO:0050811 0.000466370982197605 0.000703379186265241 790 633.090909090909 679 4.66468886968672e-05 351 0.961210060446406 0.896723198783651 1 4.03365619455253 679 395 789 508 561 757 707 351 773 658 786 767 M18879 GO_PEPTIDOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDOGLYCAN_BINDING.html Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. 4/26 Gene Ontology MF GO:0042834 0.0066761819371145 0.00849527991997972 560 663.181818181818 679 0.000669632428865401 321 1.51204792727983 1.51204792727983 1 4.16764866304318 558 766 837 623 874 679 571 321 788 568 710 768 M18173 GO_GLYCINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_BINDING.html Interacting selectively and non-covalently with glycine, aminoethanoic acid. 5/15 Gene Ontology MF GO:0016594 0.0434433628923886 0.0507851256175318 885 676.727272727273 680 0.00443167890064117 382 0.766536488433311 -0.766536488433311 -1 1.32049867044867 618 807 680 847 884 382 443 634 884 844 421 769 M18131 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol phosphate. 75/175 Gene Ontology MF GO:1901981 6.05601989131688e-07 1.83879151815562e-06 755 623.454545454545 683 5.50547414398192e-08 283 1.45853528001703 -1.34580188212615 -1 11.1344443353843 776 754 367 536 283 753 683 876 554 508 768 770 M18713 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. 19/43 Gene Ontology MF GO:0044390 0.000238390731234515 0.000378137021958196 685 629 683 2.16742333669206e-05 404 0.842546637314486 -0.785363931163764 -1 3.83796642885044 683 746 507 734 539 404 575 753 800 727 451 771 M18869 GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY.html Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. 5/14 Gene Ontology MF GO:0045125 0.00153451876974668 0.00212294326040142 720 595.818181818182 684 0.000153557943724873 248 1.87593111420019 2.32368425415015 1 6.67434437309832 717 248 834 336 607 845 684 742 362 385 794 772 M18956 GO_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_BINDING.html Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 239/607 Gene Ontology MF GO:0003682 6.52355979521939e-05 0.000112813440067704 920 676.727272727273 684 5.93068476672495e-06 405 1.57193589703432 -1.35225046211924 -1 8.25952457745403 919 842 405 813 492 500 834 788 523 684 644 773 M17850 GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 28/77 Gene Ontology MF GO:0004712 0.0839184282471183 0.0904039273856544 725 626.454545454545 685 0.00793650793650794 352 0.968402834824198 0.97063312175313 1 1.34542991263081 479 737 485 687 723 652 352 808 723 685 560 774 M18641 GO_MHC_CLASS_I_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 22/68 Gene Ontology MF GO:0042288 0.0655192111059534 0.0748790984068038 465 639.909090909091 686 0.00614144646795732 356 1.2222041207 -0.817042692735982 -1 1.83115698562406 461 786 457 809 772 356 631 800 738 686 543 775 M18049 GO_POLY_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_BINDING.html Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. 9/22 Gene Ontology MF GO:0008143 2.23244240563192e-05 4.15758504692584e-05 715 625.909090909091 689 2.23246483304494e-06 120 2.01476526870487 -0.864181405940828 -1 11.7488739631777 823 712 651 578 758 684 899 120 258 689 713 776 M18561 GO_LRR_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LRR_DOMAIN_BINDING.html Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. 12/25 Gene Ontology MF GO:0030275 0.0475223111772056 0.0552026847007944 470 644.454545454545 689 0.00441645466003902 413 1.17286881810465 1.5035527517527 1 1.96393175054791 515 850 468 768 745 782 470 413 656 733 689 777 M18739 GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. 11/18 Gene Ontology MF GO:0015101 0.0017757417446828 0.00244197668924989 615 647.818181818182 690 0.000161561515078164 386 1.2171239298486 1.08920237259304 1 4.23188308084735 612 757 386 815 608 718 560 710 807 463 690 778 M19047 GO_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEAMINASE_ACTIVITY.html Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). 11/28 Gene Ontology MF GO:0019239 2.81777122407044e-06 6.56601318730389e-06 900 691.545454545455 691 2.5616134846297e-07 365 1.00307309595853 -0.88541187041041 -1 6.91944503346122 898 600 411 691 365 823 917 801 663 605 833 779 M18191 GO_CATION_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). 8/28 Gene Ontology MF GO:0015491 0.00296611459346205 0.00395481945794939 805 727.454545454545 692 0.00029700810727799 512 1.73118083958213 1.87863498627762 1 5.53676453655669 908 781 684 668 623 692 804 874 654 512 802 780 M18798 GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. 10/16 Gene Ontology MF GO:0004549 9.77231383090597e-05 0.000165267072140322 700 685.545454545455 692 8.88431630932285e-06 505 0.626009204964788 -0.6636597530532 -1 3.15110964506375 699 673 540 714 505 669 786 662 716 885 692 781 M18819 GO_TITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TITIN_BINDING.html Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. 14/28 Gene Ontology MF GO:0031432 0.00696897147935171 0.00884338449793597 820 635.545454545455 692 0.000635558690027596 302 1.54898648943809 -1.51205524474852 -1 4.2335040896397 819 558 302 310 648 860 750 794 692 415 843 782 M19216 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. 8/14 Gene Ontology MF GO:0097153 0.00102937263177462 0.00147741469771085 920 733.454545454545 694 0.000102984976647205 588 1.14163399924182 1.3298506704955 1 4.30102924245832 842 626 919 694 588 754 849 595 604 679 918 783 M18595 GO_RAGE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAGE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. 3/18 Gene Ontology MF GO:0050786 0.0205579812664121 0.0248859773224989 780 634.181818181818 695 0.00207506787452475 369 1.16521638211684 1.16521638211684 1 2.48774485028153 458 730 776 695 876 525 369 882 780 503 382 784 M19180 GO_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_BINDING.html Interacting selectively and non-covalently with an RNA molecule or a portion thereof. 910/2094 Gene Ontology MF GO:0003723 0.0032586717616187 0.00431985305574813 250 642.818181818182 696 0.00032634601707589 200 1.07241365660975 -0.906380694259665 -1 3.37512632597344 246 889 909 879 838 200 504 579 696 915 416 785 M18249 GO_PHOSPHATIDYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BINDING.html Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. 6/28 Gene Ontology MF GO:0031210 3.35291973720456e-05 6.06028714779605e-05 700 648.454545454545 697 3.35297032759729e-06 301 1.10918497932748 -0.942633477353138 -1 6.22647889716998 899 301 697 466 476 830 853 697 657 433 824 786 M18772 GO_RETINOIC_ACID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. 16/135 Gene Ontology MF GO:0042974 0.00163544881160778 0.00225241453095682 700 677.454545454545 697 0.000148787804352392 418 1.13133291312867 1.23609197680761 1 3.98643569350541 697 580 418 489 605 888 878 824 789 469 815 787 M17868 GO_IMMUNOGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_BINDING.html Interacting selectively and non-covalently with an immunoglobulin. 4/24 Gene Ontology MF GO:0019865 0.0475867855332782 0.0552078722454173 605 663.090909090909 698 0.00486376236997989 403 1.75323595778184 -1.75323595778184 -1 2.93564352877009 703 602 610 601 698 699 403 787 817 556 818 788 M18416 GO_RNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with an RNA polymerase molecule or complex. 21/48 Gene Ontology MF GO:0070063 0.00017135827649304 0.000277064348635495 870 685 698 1.55792386423969e-05 391 0.945264097455231 -0.831796982479092 -1 4.47580280090554 866 391 494 642 531 761 679 886 698 743 844 789 M18965 GO_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. 52/315 Gene Ontology MF GO:0003823 0.000169537115331574 0.000274602369903253 530 664.090909090909 698 1.54136528786903e-05 234 1.96789528819201 -1.38345959765953 -1 9.3280915676301 846 788 234 698 529 556 876 907 551 529 791 790 M17851 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. 12/27 Gene Ontology MF GO:0016814 0.0839184282471183 0.0904039273856544 695 696.454545454545 699 0.00793650793650794 406 1.07831926991843 -0.977073605556153 -1 1.49814011207333 648 691 406 764 725 824 695 699 726 614 869 791 M18064 GO_LYSINE_ACETYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_ACETYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. 6/21 Gene Ontology MF GO:0070577 0.0765897756730953 0.0848946911075273 625 725.636363636364 699 0.00793650793650794 622 1.16082797236574 1.16082797236574 1 1.65496303699068 691 747 657 652 898 918 699 734 625 622 739 792 M18017 GO_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a substrate. 16/35 Gene Ontology MF GO:0032451 0.057015622014754 0.0655679653169671 635 681.363636363636 700 0.0053226535568937 364 0.449273527812808 -0.449273527812808 -1 0.707604917300101 635 848 571 772 819 364 700 666 855 832 433 793 M18027 GO_CARBOXY_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_LYASE_ACTIVITY.html Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. 14/37 Gene Ontology MF GO:0016831 0.0390218228918637 0.0457325822426938 845 683.363636363636 700 0.00361196825545188 358 1.10885990755387 -1.29034228304307 -1 1.9773834181899 843 703 358 707 687 843 769 700 684 668 555 794 M19122 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. 5/18 Gene Ontology MF GO:0015095 0.0695369146032585 0.0790778262484522 325 685.909090909091 700 0.00718137733588245 325 0.836679566006545 0.836679566006545 1 1.22716116480841 325 700 898 804 816 555 327 686 859 909 666 795 M18352 GO_INTERLEUKIN_1_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the interleukin-1 receptor. 20/51 Gene Ontology MF GO:0005149 0.000273540645755674 0.000430011638817043 705 671.636363636364 701 2.48704238915187e-05 410 1.32760309544777 -1.48236659459435 -1 5.94883843166638 802 618 410 795 544 807 764 668 701 574 705 796 M19020 GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. 51/118 Gene Ontology MF GO:0019783 0.00486121031050257 0.0062990330783977 575 645 701 0.000442907744289131 216 0.897244459560562 -0.859551184963792 -1 2.62820609330946 574 774 592 878 732 216 701 616 854 784 374 797 M18987 GO_2_IRON_2_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_IRON_2_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. 12/29 Gene Ontology MF GO:0051537 0.0493726832224221 0.0572076430284992 920 692.727272727273 702 0.00459243861671812 503 0.719874451383934 -0.93437241027546 -1 1.19056090288364 920 550 503 744 695 572 702 658 735 736 805 798 M18136 GO_GLUCOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. 5/12 Gene Ontology MF GO:0015926 0.00540412948787892 0.00694348404588194 645 718.636363636364 703 0.000541731672211662 570 0.591351590109304 -0.659060669467643 -1 1.69888808028895 731 570 670 692 643 644 863 716 831 842 703 799 M18975 GO_DOUBLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with double-stranded RNA. 64/150 Gene Ontology MF GO:0003725 0.0839184282471183 0.0904039273856544 830 685.818181818182 703 0.00793650793650794 440 1.42355405264212 -0.98954967898935 -1 1.97778514858705 827 857 440 703 855 631 757 494 501 667 812 800 M18847 GO_FUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 4/11 Gene Ontology MF GO:0008417 0.0560530774609737 0.0646225955690424 545 679.545454545455 704 0.00575192800775448 453 0.740401489009284 0.740401489009284 1 1.17234740906289 453 772 828 796 704 519 545 559 868 887 544 801 M18442 GO_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 75/156 Gene Ontology MF GO:0004386 0.0839184282471183 0.0904039273856544 730 661.818181818182 705 0.00793650793650794 408 1.10346478884945 -0.746948625857769 -1 1.5330755355862 441 876 593 705 736 408 617 730 730 805 639 802 M18007 GO_NEUROPEPTIDE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neuropeptide receptor. 3/31 Gene Ontology MF GO:0071855 0.0635497687965775 0.0728091996174986 805 686.636363636364 706 0.00654438183386122 469 0.535540585686036 -0.535540585686036 -1 0.811046513014941 557 801 635 805 706 469 502 807 900 831 540 803 M18020 GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding. 10/22 Gene Ontology MF GO:0044183 0.0839184282471183 0.0904039273856544 920 687.636363636364 706 0.00793650793650794 209 1.67164127812021 -0.902795291110037 -1 2.32246017056555 779 884 414 209 916 688 725 920 659 706 664 804 M18300 GO_AMINOACYL_TRNA_EDITING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOACYL_TRNA_EDITING_ACTIVITY.html The hydrolysis of an incorrectly aminoacylated tRNA. 7/11 Gene Ontology MF GO:0002161 0.33296556889208 0.344576291766832 710 718.090909090909 706 0.0396825396825397 616 0.41804490327357 -0.41804490327357 -1 0.257464273763138 630 685 706 669 792 616 645 770 827 851 708 805 M17872 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. 11/30 Gene Ontology MF GO:0035255 0.0839184282471183 0.0904039273856544 905 677.727272727273 707 0.00793650793650794 394 0.96649174316866 -0.855009596515191 -1 1.34277477568409 901 451 394 473 715 650 913 707 671 718 862 806 M18543 GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. 50/118 Gene Ontology MF GO:1902936 3.89640178166309e-05 6.96056240607776e-05 830 651.727272727273 707 3.54224617474866e-06 361 1.53061893811806 -1.53162845736375 -1 8.4696806331499 830 707 361 554 478 717 816 831 595 495 785 807 M18512 GO_OMEGA_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OMEGA_PEPTIDASE_ACTIVITY.html Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). 10/15 Gene Ontology MF GO:0008242 0.00323008067682365 0.0042881301914542 915 684.636363636364 708 0.000294075719283338 276 0.878972709884943 -0.719063736660055 -1 2.7700690080245 915 584 508 696 693 808 847 276 777 708 719 808 M19168 GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. 4/61 Gene Ontology MF GO:0008391 0.000695746058877864 0.00102413819866822 900 694 709 6.95963983070226e-05 355 0.906654065333863 -0.897442443077854 -1 3.60780791292193 900 355 904 525 571 709 796 793 677 570 834 809 M19183 GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. 24/53 Gene Ontology MF GO:0005547 0.0839184282471183 0.0904039273856544 715 717.727272727273 710 0.00793650793650794 403 1.83665976949906 1.75164389449578 1 2.55172530920076 715 916 403 685 770 909 692 564 675 710 856 810 M18313 GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. 6/21 Gene Ontology MF GO:0004303 0.178604777992088 0.188005029465356 660 689.454545454545 712 0.0194827980460942 459 0.245456071302543 -0.279185321288657 -1 0.237131731087016 660 806 712 749 885 459 463 514 908 852 576 811 M19136 GO_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. 28/60 Gene Ontology MF GO:0003678 0.409766256458883 0.422628874374632 905 706.545454545455 712 0.0468000670457193 418 0.547122388123759 -0.547122388123759 -1 0.272385788661386 418 905 563 741 824 521 607 712 901 911 669 812 M18223 GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. 16/32 Gene Ontology MF GO:0015036 0.0901026939824847 0.0969526063905099 715 674.454545454545 713 0.00854722087694047 464 1.22212721636498 -1.22212721636498 -1 1.64853129645246 713 776 464 841 826 538 704 510 821 755 471 813 M18677 GO_RAL_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAL_GTPASE_BINDING.html Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. 8/21 Gene Ontology MF GO:0017160 0.0371874606556653 0.0437499537125474 810 710.636363636364 713 0.00378248325272197 336 0.478343492698265 -0.478343492698265 -1 0.865264175325151 807 336 796 629 689 642 844 786 713 879 696 814 M18737 GO_ANION_ANION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_ANION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). 4/29 Gene Ontology MF GO:0015301 0.0765897756730953 0.0848946911075273 805 672.636363636364 716 0.00793650793650794 489 1.3550684932328 -0.589860161116269 -1 1.93188702605582 905 508 803 498 802 752 716 520 489 565 841 815 M18902 GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). 2/13 Gene Ontology MF GO:0005451 0.238819737997698 0.249959225208057 570 728.8 716 0.0298655062815334 511 0.243389648955671 -0.243389648955671 -1 0.195062218871955 700 732 845 NA 901 511 568 675 897 890 569 816 M18908 GO_POLY_A_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_RNA_BINDING.html Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. 700/1614 Gene Ontology MF GO:0044822 0.00997607790281831 0.0123859536715153 335 669.545454545455 718 0.00100211478836183 260 1.06059890954957 -0.895327890582663 -1 2.69215819801676 331 890 847 864 857 260 577 660 718 891 470 817 M18062 GO_PRENYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRENYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). 7/16 Gene Ontology MF GO:0004659 0.00125407879843857 0.00177500383778997 600 727.454545454545 719 0.00012547870821923 568 0.525219753317384 -0.583577039348381 -1 1.92301531307111 739 568 656 679 596 719 910 894 805 838 598 818 M18592 GO_DYNEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_BINDING.html Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. 13/55 Gene Ontology MF GO:0045502 0.137272638457565 0.14549634490894 860 709.636363636364 721 0.0133336323449551 472 1.20974808427372 -1.40197725353511 -1 1.34796803591046 857 739 472 655 721 836 656 635 811 641 783 819 M18809 GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING.html Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. 17/34 Gene Ontology MF GO:0001098 2.59774855556217e-07 9.40916799652439e-07 795 670.363636363636 721 2.36158987482092e-08 229 0.867562993402678 -0.781743466425062 -1 6.95897452098164 795 384 512 721 229 804 822 881 635 702 889 820 M18055 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY.html Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. 13/39 Gene Ontology MF GO:0061650 0.261607135599644 0.273187928208482 875 734.545454545455 722 0.0271942351669433 452 0.885905105499969 -0.976035824232904 -1 0.664496732507094 696 888 452 873 737 689 870 640 875 638 722 821 M18205 GO_SINGLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with single-stranded RNA. 52/138 Gene Ontology MF GO:0003727 0.0435353622453028 0.0508280879006073 820 704.181818181818 722 0.00403832044181909 379 1.38359858236727 -0.955099308049592 -1 2.38282512744487 820 879 448 861 692 379 811 722 640 699 795 822 M18860 GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. 11/18 Gene Ontology MF GO:0034979 0.000154361103875689 0.000252840048667073 920 628.909090909091 722 1.40338123230464e-05 190 0.719991410701016 -0.652472078459013 -1 3.44722035636874 918 190 463 236 523 781 872 776 637 722 800 823 M19051 GO_METALLOAMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOAMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 7/13 Gene Ontology MF GO:0070006 0.00268175499223048 0.00360703887843866 725 722.636363636364 723 0.000268499681406873 576 1.15014092845021 -0.458248432049697 -1 3.73964525779183 677 576 878 641 619 855 783 723 809 663 725 824 M18048 GO_UNFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with an unfolded protein. 55/120 Gene Ontology MF GO:0051082 0.0413021166643896 0.0483434444417792 455 667.636363636364 726 0.00382713838041076 325 0.990507749355566 -0.732177161455614 -1 1.734542236208 455 901 559 843 868 325 530 726 795 780 562 825 M18248 GO_METALLOENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 31/124 Gene Ontology MF GO:0004222 1.857457008371e-06 4.60387008875495e-06 730 639.727272727273 727 1.68859870601934e-07 345 1.40438516857048 -1.24895026292281 -1 9.97599456233592 832 661 365 837 345 755 727 802 573 412 728 826 M18318 GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. 6/11 Gene Ontology MF GO:0008568 0.323440655304603 0.335096174414679 920 752.818181818182 727 0.0383199877126518 558 0.231528055418868 -0.231528055418868 -1 0.14632602364741 727 919 714 771 891 568 696 558 916 854 667 827 M19012 GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. 7/20 Gene Ontology MF GO:0008353 0.0537197802217886 0.0620102858269078 605 686.727272727273 728 0.00550643752702925 348 0.386790298712793 -0.386790298712793 -1 0.621666921636994 603 873 870 657 728 348 444 741 914 898 478 828 M19113 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_.html Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. 7/19 Gene Ontology MF GO:0042800 0.0222956782316884 0.0268833865965312 565 673 728 0.0022522582654238 365 0.565133789737079 -0.565133789737079 -1 1.18134308243567 561 789 895 609 785 365 728 506 869 908 388 829 M19161 GO_4_IRON_4_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_IRON_4_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. 25/42 Gene Ontology MF GO:0051539 0.0839184282471183 0.0904039273856544 555 708.818181818182 729 0.00793650793650794 518 0.790863083667432 -0.933606379254944 -1 1.0987686122995 661 895 552 869 821 553 729 518 764 787 648 830 M18633 GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. 12/21 Gene Ontology MF GO:0052745 0.0921639595401992 0.0990547228703076 585 651.090909090909 734 0.00875161506059572 402 1.02250745169149 -1.03069475295945 -1 1.36658495761947 585 763 402 846 760 454 749 459 860 734 550 831 M19013 GO_ENDORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. 26/63 Gene Ontology MF GO:0004521 0.146649440856028 0.155256024841824 620 709.272727272727 734 0.0143133794842594 474 0.624236432310462 -0.646472206632644 -1 0.672130622601635 617 886 556 858 863 474 734 515 883 899 517 832 M18084 GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. 2/7 Gene Ontology MF GO:0004523 0.717910734112153 0.733864305981312 715 748.4 734.5 0.131175938174569 646 0.247592656839283 -0.247592656839283 -1 0.0442850647438433 712 692 662 NA 798 646 755 737 910 840 732 833 M17992 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. 5/10 Gene Ontology MF GO:0052629 0.316898401347059 0.32868830804881 825 722.090909090909 736 0.0373940757394418 570 0.614331425000703 -0.614331425000703 -1 0.395116654553647 671 822 631 736 749 570 825 602 840 829 668 834 M18417 GO_CARBOHYDRATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. 7/20 Gene Ontology MF GO:0019200 0.0240234957685919 0.0288434809580453 760 688.636363636364 736 0.00242872250856412 394 1.60543932317376 -1.60543932317376 -1 3.29066633929699 576 885 736 670 757 507 831 757 806 656 394 835 M18730 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. 12/30 Gene Ontology MF GO:0016628 0.0839184282471183 0.0904039273856544 615 716 737 0.00793650793650794 443 1.50051986016464 -0.986534451778321 -1 2.08471605302316 614 799 443 737 866 774 507 916 703 735 782 836 M18748 GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any N-glycosyl bond. 9/26 Gene Ontology MF GO:0016799 0.0765897756730953 0.0848946911075273 810 728.727272727273 739 0.00793650793650794 583 0.810212178784007 -0.650665951037491 -1 1.1550986227352 806 711 807 615 899 583 605 796 739 692 763 837 M17953 GO_MAGNESIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_BINDING.html Interacting selectively and non-covalently with magnesium (Mg) ions. 114/271 Gene Ontology MF GO:0000287 0.0040797996023076 0.00533914030458463 765 680.363636363636 740 0.000371580464142237 207 1.08479946667627 -0.934845077621171 -1 3.28126652991039 762 773 575 849 875 207 740 645 727 808 523 838 M19000 GO_ANGIOTENSIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOTENSIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an angiotensin receptor. 7/21 Gene Ontology MF GO:0031701 0.0765897756730953 0.0848946911075273 905 730 740 0.00793650793650794 454 1.63793034024404 -0.739338359774914 -1 2.33515628562652 740 481 867 454 806 903 918 692 603 662 904 839 M18054 GO_NUCLEOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_BINDING.html Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. 35/80 Gene Ontology MF GO:0031491 0.0839184282471183 0.0904039273856544 750 600 744 0.00793650793650794 230 2.40192579469904 -1.28916807832758 -1 3.33706634916778 749 755 242 369 833 744 807 582 230 488 801 840 M18431 GO_OXYGEN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORTER_ACTIVITY.html Enables the directed movement of oxygen into, out of or within a cell, or between cells. 5/17 Gene Ontology MF GO:0005344 0.0765897756730953 0.0848946911075273 740 777.272727272727 745 0.00793650793650794 594 1.49912582466066 -0.780336948137207 -1 2.13726606177404 773 716 739 710 843 896 739 911 745 594 884 841 M17996 GO_RNA_POLYMERASE_III_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_III_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 9/21 Gene Ontology MF GO:0001056 0.291377701264063 0.302901113178461 730 735.272727272727 746 0.0338568446763744 550 0.865031143631162 -0.865031143631162 -1 0.597212973353024 728 840 634 810 870 564 746 550 842 830 674 842 M18454 GO_OLIGOPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOPEPTIDE_BINDING.html Interacting selectively and non-covalently with an oligopeptide. 10/20 Gene Ontology MF GO:1900750 0.0839184282471183 0.0904039273856544 825 730.454545454545 746 0.00793650793650794 450 0.988167386659188 -0.766536488433311 -1 1.37288939719311 825 620 450 682 886 694 802 830 746 707 793 843 M18723 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. 11/32 Gene Ontology MF GO:0016538 0.0133324414245896 0.0164421529633008 910 697.545454545455 747 0.00121944826531115 352 1.52348428660902 1.90262610154629 1 3.61764191533187 759 827 422 818 747 906 690 352 643 603 906 844 M19112 GO_TRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. 13/20 Gene Ontology MF GO:0008175 0.129590693332653 0.137830564006983 750 690 748 0.0125381622108751 448 0.618572743128592 -0.618572743128592 -1 0.708600919631409 659 750 522 748 752 448 758 671 870 907 505 845 M18859 GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. 7/39 Gene Ontology MF GO:0005251 0.0765897756730953 0.0848946911075273 635 679.090909090909 749 0.00793650793650794 311 2.0111337415172 1.71590446625069 1 2.8672233031155 632 805 830 588 910 749 642 798 344 311 861 846 M18479 GO_TRANSITION_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_BINDING.html Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 586/1709 Gene Ontology MF GO:0046914 2.70100831073454e-08 2.15926568991322e-07 895 650.272727272727 750 2.70100834356405e-09 90 1.38520451457014 -1.09725424314696 -1 12.2897219140307 895 854 750 898 90 166 905 806 518 739 532 847 M18045 GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. 7/13 Gene Ontology MF GO:0052744 0.174528611960393 0.183924768618054 755 724.636363636364 751 0.0189973005013662 509 0.614331425000703 -0.614331425000703 -1 0.601290830047203 751 830 649 769 731 509 773 548 896 836 679 848 M18695 GO_PROTEIN_PHOSPHATASE_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_1_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 1. 9/30 Gene Ontology MF GO:0008157 0.0765897756730953 0.0848946911075273 755 747.272727272727 751 0.00793650793650794 601 0.891128280119457 -0.689442095167172 -1 1.27045874152703 774 751 800 632 751 894 711 601 717 691 898 849 M18221 GO_PHOSPHOLIPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_BINDING.html Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. 15/29 Gene Ontology MF GO:0043274 0.0839184282471183 0.0904039273856544 675 714.181818181818 752 0.00793650793650794 435 2.00627611875977 -2.00627611875977 -1 2.78737838967149 675 837 514 740 799 773 435 696 756 752 879 850 M18490 GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 3/12 Gene Ontology MF GO:0015129 0.105129809252233 0.112595371958154 915 748.909090909091 752 0.011046198661721 500 1.38125031809021 -1.38125031809021 -1 1.74374453023378 913 675 752 693 714 857 864 637 778 500 855 851 M17928 GO_RNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. 26/48 Gene Ontology MF GO:0008173 0.0676629105081855 0.0772330988430902 525 662.363636363636 753 0.00634892763410032 360 0.746992892138502 -0.76104232798774 -1 1.10580964943324 525 819 553 862 753 360 763 525 801 823 502 852 M18570 GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. 38/83 Gene Ontology MF GO:0004843 0.126201447953683 0.134381171432163 745 715.181818181818 754 0.0121892311173263 420 0.946992465665816 -0.896632827532035 -1 1.09869409404437 743 824 579 876 754 420 914 605 861 775 516 853 M19070 GO_RIBOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BINDING.html Interacting selectively and non-covalently with any part of a ribosome. 30/56 Gene Ontology MF GO:0043022 0.0923306447697413 0.0991180783992556 620 710.636363636364 755 0.00876816192671611 393 0.55825305520764 -0.55825305520764 -1 0.745900383207955 616 894 596 844 755 393 628 759 863 904 565 854 M18450 GO_LAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMIN_BINDING.html Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. 12/29 Gene Ontology MF GO:0005521 0.0839184282471183 0.0904039273856544 690 750.090909090909 759 0.00793650793650794 491 0.923572278794099 -0.593815160276778 -1 1.28314547676272 686 838 491 745 759 873 772 918 661 732 776 855 M18682 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. 4/13 Gene Ontology MF GO:0050664 0.0361288585772089 0.0426135255013233 785 699.727272727273 759 0.00367300435935602 472 1.23426091699872 -0.684562175544471 -1 2.2514047552938 782 472 797 560 688 759 638 840 819 564 778 856 M18520 GO_SUMO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_BINDING.html Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. 6/17 Gene Ontology MF GO:0032183 0.749973962645837 0.765789173844806 675 778.454545454545 760 0.129440370395447 649 0.250827365612269 -0.3034957081115 -1 0.0386895173100482 755 852 760 819 862 675 649 674 911 870 736 857 M18154 GO_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_BINDING.html Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. 91/227 Gene Ontology MF GO:0003729 0.0839184282471183 0.0904039273856544 915 753.454545454545 761 0.00793650793650794 599 1.34997473279448 1.58420484631824 1 1.87555919303141 613 914 599 832 724 763 741 761 636 792 913 858 M18523 GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING.html Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. 6/17 Gene Ontology MF GO:0033612 1.35369226262374e-05 2.65300000568127e-05 765 578.545454545455 761 1.35370050886677e-06 26 3.08316098686696 2.61780205670429 1 18.7797565766276 761 237 762 92 442 871 919 914 26 437 903 859 M18716 GO_PROTEIN_KINASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVITY.html Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. 9/16 Gene Ontology MF GO:0004697 0.0765897756730953 0.0848946911075273 765 711.090909090909 764 0.00793650793650794 455 1.39907479808939 -1.39321719381952 -1 1.994625745199 764 515 802 455 808 835 604 906 685 549 899 860 M17873 GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. 208/483 Gene Ontology MF GO:0019787 0.00208640723108717 0.00282694352371163 770 691 767 0.00018985350380058 182 1.06185550373137 -0.988121309316193 -1 3.60216756444566 767 875 605 897 877 182 845 648 697 812 396 861 M18794 GO_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_ACTIVITY.html Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. 40/144 Gene Ontology MF GO:0003774 0.0839184282471183 0.0904039273856544 915 715.909090909091 767 0.00793650793650794 328 1.56322142896493 -1.33864845312114 -1 2.17182922284751 914 810 328 767 828 682 709 892 569 779 597 862 M18896 GO_K63_LINKED_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_K63_LINKED_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. 9/19 Gene Ontology MF GO:0070530 0.028143741897554 0.0335391742820592 820 741.545454545455 767 0.00285066592037925 537 1.13222709097801 -1.38487097311767 -1 2.22200737161623 817 804 842 758 679 858 537 774 626 695 767 863 M18401 GO_FATTY_ACID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORTER_ACTIVITY.html Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 5/20 Gene Ontology MF GO:0015245 0.437242282663751 0.450462374076877 915 784.363636363636 768 0.0558692429149729 627 0.460065913238562 -0.466172657150886 -1 0.21208256495619 765 783 732 724 768 627 912 791 913 862 751 864 M19092 GO_PRE_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MRNA_BINDING.html Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. 16/40 Gene Ontology MF GO:0036002 0.202176743675791 0.212331739933479 775 721.363636363636 769 0.0203240955516016 539 0.817285157164203 -0.817285157164203 -1 0.732084441782183 775 861 543 859 769 569 821 557 886 756 539 865 M18826 GO_HSP70_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP70_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. 19/36 Gene Ontology MF GO:0030544 0.0964897090598015 0.103462158898622 755 738.454545454545 770 0.00918192979552857 463 0.878026312908818 -1.02453984974362 -1 1.15139001329545 752 907 532 874 903 571 879 463 851 770 621 866 M17893 GO_HEAT_SHOCK_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAT_SHOCK_PROTEIN_BINDING.html Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. 58/119 Gene Ontology MF GO:0031072 0.0565307963017548 0.0650917804726088 785 712.090909090909 771 0.00527617322553294 347 1.00519280737195 1.06183338631946 1 1.58741343098163 781 878 584 850 771 347 803 687 758 796 578 867 M19067 GO_TAU_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. 8/26 Gene Ontology MF GO:0050321 0.000752563508221558 0.0010989816310537 805 744.272727272727 772 7.52818488084612e-05 545 0.7333231089732 -0.661644568467725 -1 2.88818091721262 801 545 887 622 576 691 855 772 751 903 784 868 M17898 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 30/65 Gene Ontology MF GO:0016627 0.0301115893868691 0.035699307005051 835 692.272727272727 776 0.00277561852885104 393 0.949072497618548 -0.783222943885335 -1 1.82832150789907 800 835 549 821 834 432 827 393 711 776 637 869 M19189 GO_PROTEIN_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHANNEL_ACTIVITY.html Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel. 4/12 Gene Ontology MF GO:0015266 0.540318324317395 0.555411014940786 880 797.636363636364 777 0.0747784936782137 644 0.250007841385512 -0.293923282384612 -1 0.0849819429442203 879 644 911 723 777 705 756 814 894 917 754 870 M17939 GO_METHYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 28/67 Gene Ontology MF GO:0035064 0.0294478177416263 0.0350025740598141 570 662.181818181818 778 0.00271359420103058 312 0.682534285027555 -0.74172919626366 -1 1.3226302936377 568 882 570 875 778 312 781 416 872 793 437 871 M18903 GO_ZINC_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_BINDING.html Interacting selectively and non-covalently with zinc (Zn) ions. 477/1372 Gene Ontology MF GO:0008270 3.84537620575665e-08 2.62055267355268e-07 900 611.818181818182 780 3.49579661179083e-09 81 1.27889011075264 -1.01224570199294 -1 11.2033516730377 780 855 583 899 104 81 823 898 572 795 340 872 M18627 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. 8/22 Gene Ontology MF GO:0016864 0.135811342919809 0.14411353573959 915 751.727272727273 782 0.0144904068024281 374 0.227534968925808 0.249334123523078 1 0.254787071014164 572 912 782 863 911 655 374 735 892 875 698 873 M18868 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. 5/29 Gene Ontology MF GO:0015347 0.00511093476314658 0.00659475453309236 415 645.454545454545 784 0.00051227276982986 167 0.639240800582038 0.998728145556692 1 1.85550936970567 415 815 833 867 784 487 167 427 839 889 577 874 M18636 GO_FOUR_WAY_JUNCTION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOUR_WAY_JUNCTION_DNA_BINDING.html Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. 7/18 Gene Ontology MF GO:0000400 0.922707991896691 0.929782423378922 720 789.090909090909 785 0.225870782520681 683 0.304197008715309 -0.304795726478187 -1 0.0128009175436355 719 831 785 702 856 683 718 837 906 877 766 875 M18943 GO_METHYL_CPG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYL_CPG_BINDING.html Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. 10/19 Gene Ontology MF GO:0008327 0.308770460988741 0.320619440304336 550 736.272727272727 785 0.0330139517533855 547 0.569789386082048 -0.569789386082048 -1 0.374655129478617 655 909 547 811 853 566 785 547 902 893 631 876 M17958 GO_SIGNAL_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. 16/50 Gene Ontology MF GO:0005048 0.161385165508919 0.170268752601153 790 762.454545454545 787 0.0158730158730159 499 1.11592899882604 1.23129931041699 1 1.14200777839971 869 797 499 872 761 608 787 827 787 754 826 877 M18729 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. 94/232 Gene Ontology MF GO:0061659 0.0760495673772494 0.0848946911075273 895 696.454545454545 788 0.00716483233593417 372 1.12492626260136 -1.04183084513211 -1 1.60377884206662 813 833 582 895 895 372 788 541 620 804 518 878 M18727 GO_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. 43/87 Gene Ontology MF GO:0008094 0.0839184282471183 0.0904039273856544 745 760.909090909091 790 0.00793650793650794 535 1.31878889981547 -0.547122388123759 -1 1.83223178007517 772 904 535 742 807 590 790 866 742 801 821 879 M18591 GO_PEPTIDE_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen peptide. 23/62 Gene Ontology MF GO:0042605 0.00903089915147164 0.0112886239393396 795 739.545454545455 791 0.000824380457713902 379 1.39142683010012 -0.927869007381074 -1 3.60652613482591 865 794 379 857 656 839 698 783 791 613 860 880 M18444 GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 2/15 Gene Ontology MF GO:0005247 0.0637024859958667 0.0728933919355688 710 792.1 794.5 0.00728687616447439 614 0.454924606938067 -0.581626629073292 -1 0.68865399827293 871 614 741 NA 707 914 706 751 838 867 912 881 M18925 GO_RETINOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_BINDING.html Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. 3/13 Gene Ontology MF GO:0019841 0.95840821932237 0.964699739361685 835 806.181818181818 795 0.272386494725123 707 0.430664671959685 0.526614831833104 1 0.00894555452534439 707 767 852 735 831 795 782 771 905 892 831 882 M18470 GO_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 24/81 Gene Ontology MF GO:0003777 0.698152987361708 0.71446134412989 770 787.272727272727 796 0.103174603174603 460 0.91272559175941 -0.996718737886629 -1 0.177392910272132 907 802 460 752 861 769 766 893 871 783 796 883 M18056 GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. 7/21 Gene Ontology MF GO:1990939 0.275742742869669 0.287297082038613 655 753.090909090909 797 0.0317460317460317 587 1.08040317999237 -1.30174126021854 -1 0.778936103457822 886 635 653 587 829 880 797 705 822 651 839 884 M19049 GO_THYROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a thyroid hormone receptor. 18/42 Gene Ontology MF GO:0046966 3.7649548912866e-06 8.51046314492303e-06 875 731.636363636364 797 3.42269212221067e-07 378 1.26856267548997 -1.24070878679315 -1 8.56064859020488 875 811 490 797 378 832 793 904 710 636 822 885 M17930 GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. 2/12 Gene Ontology MF GO:0043855 0.13411491204602 0.142477735660899 780 776.8 802 0.0158730158730159 494 1.06507034015571 -0.577609231254809 -1 1.19966755252476 848 494 621 NA 906 899 780 698 779 824 919 886 M18985 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. 9/17 Gene Ontology MF GO:0005337 3.62310118473188e-05 6.5102599413151e-05 865 712.090909090909 803 3.62316025696725e-06 480 1.252031764314 1.07760334566336 1 6.97652252346032 862 560 866 803 480 826 840 586 650 553 807 887 M18385 GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. 2/8 Gene Ontology MF GO:0003964 0.894332221140263 0.905154723266273 735 798 806.5 0.22097898146027 636 0.0955403102732308 -0.0284783858708764 -1 0.00550218003219694 732 874 730 NA 880 844 636 736 918 861 769 888 M18972 GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. 6/12 Gene Ontology MF GO:0004535 0.0296584683481668 0.0352074721036303 895 705.181818181818 807 0.00300618983195677 316 0.574637850184293 -0.574637850184293 -1 1.11160717544626 570 759 863 807 892 316 408 835 893 895 519 889 M18194 GO_RAN_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAN_GTPASE_BINDING.html Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. 12/38 Gene Ontology MF GO:0008536 0.184055551146557 0.193521265205523 860 773.090909090909 808 0.0183218046178826 497 0.620937310649371 -0.66103307444649 -1 0.589500893414639 836 672 497 808 730 731 857 856 879 846 792 890 M18751 GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY.html Combining with a protein hormone to initiate a change in cell activity. 3/23 Gene Ontology MF GO:0016500 0.692053852342561 0.709008401063649 810 777.636363636364 808 0.111111111111111 447 0.728030379581122 0.728030379581122 1 0.144720477035609 734 719 808 447 905 806 675 875 874 882 829 891 M18525 GO_RETINAL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_BINDING.html Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. 3/18 Gene Ontology MF GO:0016918 0.847766564265896 0.860866709850579 785 817.727272727273 809 0.171579180405798 706 0.533759810413593 -0.632186261892676 -1 0.0462230813016535 784 809 763 853 907 767 850 706 895 872 789 892 M18541 GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. 12/25 Gene Ontology MF GO:0015035 0.767314927636576 0.782627198919789 900 787.727272727273 809 0.124142401491209 488 0.785961060969852 -0.785961060969852 -1 0.111353727553679 896 780 488 799 890 670 897 809 882 873 681 893 M19102 GO_ADENYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. 664/1625 Gene Ontology MF GO:0030554 3.01169624453168e-08 2.2707385136175e-07 815 657.272727272727 811 3.0116962853481e-09 94 1.32878524995729 -1.04361913013274 -1 11.7504983627805 811 853 892 881 94 209 771 832 565 811 511 894 M19203 GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. 8/13 Gene Ontology MF GO:0046030 0.0765897756730953 0.0848946911075273 895 812.272727272727 811 0.00793650793650794 678 1.03270581777863 -1.05008595272413 -1 1.47230239554725 891 752 915 792 893 741 892 879 691 678 811 895 M18769 GO_RIBONUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. 824/1976 Gene Ontology MF GO:0032553 3.80442008554213e-08 2.62055267355268e-07 855 660 812 3.80442015067339e-09 106 1.34276020919536 -1.07928543970146 -1 11.7628674938191 854 866 812 893 106 208 828 822 553 810 508 896 M19154 GO_DNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with a DNA polymerase. 7/16 Gene Ontology MF GO:0070182 0.557629063946084 0.572565556730354 785 796.090909090909 812 0.0783231940294414 610 0.785022380376165 -0.409216788386589 -1 0.253041498273498 805 782 902 610 781 812 859 817 878 664 847 897 M18944 GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING.html Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 8/25 Gene Ontology MF GO:0090079 0.038453257332183 0.0451813496112495 795 788.454545454545 813 0.00391353217617031 633 0.373927580207424 -0.373927580207424 -1 0.669429767626465 793 813 860 747 690 633 832 888 816 894 707 898 M18861 GO_PHOSPHATIDIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_BINDING.html Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 6/19 Gene Ontology MF GO:0070300 0.776430316378975 0.790128237274685 660 792.818181818182 814 0.139122630766372 656 0.258565417365463 -0.331463665767831 -1 0.0352066363426549 910 814 831 656 847 657 737 684 889 888 808 899 M18511 GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING.html Interacting selectively and non-covalently with any part of the small ribosomal subunit. 9/22 Gene Ontology MF GO:0043024 0.386086746459241 0.398652981753649 780 817 816 0.0476190476190476 718 0.322510950890019 0.319489178672285 1 0.171450111729696 912 787 757 718 872 777 866 779 834 869 816 900 M18717 GO_AU_RICH_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AU_RICH_ELEMENT_BINDING.html Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. 10/26 Gene Ontology MF GO:0017091 0.268075156426362 0.279624879719108 830 739.272727272727 816 0.0279720080529008 421 0.864181405940828 -0.864181405940828 -1 0.636568403833259 560 828 501 816 830 775 421 871 862 881 787 901 M18112 GO_POLY_PYRIMIDINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PYRIMIDINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. 11/26 Gene Ontology MF GO:0008187 0.0839184282471183 0.0904039273856544 865 757.909090909091 818 0.00793650793650794 433 1.41620633394393 -0.717915985173146 -1 1.9675767426568 861 910 433 838 865 726 818 533 753 720 880 902 M18355 GO_PROTEIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of proteins into, out of or within a cell, or between cells. 51/119 Gene Ontology MF GO:0008565 0.0839184282471183 0.0904039273856544 885 765.181818181818 818 0.00793650793650794 465 1.22027997117796 -0.900650063843639 -1 1.69537037144045 881 902 545 868 920 465 884 818 705 772 657 903 M18872 GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a macromolecule from one side of the membrane to the other. 11/35 Gene Ontology MF GO:0022884 0.232850105696956 0.243988721231434 845 779.636363636364 823 0.0238095238095238 412 2.76062198982286 2.76062198982286 1 2.25106472869301 845 908 412 823 803 868 848 685 808 723 853 904 M18639 GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. 7/11 Gene Ontology MF GO:0051766 0.632427457617131 0.64864354627398 830 807.454545454545 827 0.0952380952380952 609 0.630899449631666 0.630899449631666 1 0.157864134150949 730 851 788 848 827 872 609 785 867 878 827 905 M17955 GO_DNA_SECONDARY_STRUCTURE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SECONDARY_STRUCTURE_BINDING.html Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. 11/27 Gene Ontology MF GO:0000217 0.921309192177062 0.929390851757562 880 799.818181818182 828 0.206349206349206 500 0.883713803362813 0.883713803362813 1 0.0374050087981399 878 820 500 728 859 737 836 910 888 828 814 906 M19191 GO_HISTONE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 15/49 Gene Ontology MF GO:0035173 0.286836000635687 0.298517104733973 760 787.909090909091 828 0.0302638560945815 416 0.728056034285013 -0.75974831432709 -1 0.508781591624102 757 762 416 828 741 863 726 870 877 918 909 907 M19055 GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY.html Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. 9/40 Gene Ontology MF GO:0008329 0.386086746459241 0.398652981753649 825 809.090909090909 830 0.0476190476190476 653 1.51204792727983 1.51204792727983 1 0.803824479038092 821 743 881 653 845 878 830 811 833 697 908 908 M17927 GO_DNA_BINDING_BENDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BINDING_BENDING.html The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. 9/24 Gene Ontology MF GO:0008301 0.975368714677481 0.978559670123536 900 824.454545454545 839 0.30952380952381 620 0.968438867808375 0.968438867808375 1 0.0121318267686371 747 839 620 784 918 904 770 896 899 822 870 909 M18072 GO_RNA_POLYMERASE_I_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_I_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 5/14 Gene Ontology MF GO:0001054 0.865868411081419 0.878278873423269 870 823 839 0.182000370573183 660 0.166328217092364 0.109473689069112 1 0.012477763400008 873 808 660 717 814 818 869 867 903 839 885 910 M18208 GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. 11/29 Gene Ontology MF GO:0005487 0.878859116702268 0.890473994896571 885 816.636363636364 840 0.174603174603175 565 0.322847914084381 -0.322847914084381 -1 0.0216473373600489 884 821 565 739 909 811 838 844 885 847 840 911 M18433 GO_TELOMERASE_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_RNA_BINDING.html Interacting selectively and non-covalently with the telomerase RNA template. 7/16 Gene Ontology MF GO:0070034 0.989171684095161 0.991326742230444 890 827 849 0.364001499458915 740 0.799072968462919 -0.799072968462919 -1 0.00402251807385339 889 897 740 761 849 747 806 782 909 866 851 912 M18380 GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. 7/25 Gene Ontology MF GO:0008139 0.91458206428639 0.924632416641185 855 854.818181818182 854 0.218093349259826 728 0.259754219331269 -0.303245072629667 -1 0.0117645385322443 902 913 728 840 823 829 893 854 907 860 854 913 M18319 GO_RRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. 7/16 Gene Ontology MF GO:0008649 0.50797582810604 0.522749174337312 860 799.454545454545 855 0.0684661434980143 494 0.269501378469764 0.317295722350345 1 0.101049883186641 694 864 715 822 858 815 494 915 904 855 858 914 M18343 GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE.html The action of a molecule that contributes to the structural integrity of the nuclear pore complex. 6/14 Gene Ontology MF GO:0017056 0.916214476854218 0.925265991993283 920 832.818181818182 858 0.219600650768244 634 0.120539312205184 -0.110806915268203 -1 0.00541098664890354 738 918 719 829 914 851 634 900 917 858 883 915 M18427 GO_MISMATCHED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCHED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. 6/14 Gene Ontology MF GO:0030983 0.975368714677481 0.978559670123536 865 844.636363636364 864 0.30952380952381 738 0.256012055685416 -0.324892835616581 -1 0.00320624145079711 864 841 738 827 873 908 791 815 898 865 871 916 M17885 GO_OLFACTORY_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_RECEPTOR_ACTIVITY.html Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. 20/849 Gene Ontology MF GO:0004984 0.775485941583084 0.790085344691514 620 799.727272727273 866 0.126984126984127 520 1.27409875260801 1.27409875260801 1 0.17352774600732 620 917 520 882 887 875 732 849 876 773 866 917 M18691 GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. 7/13 Gene Ontology MF GO:0043142 0.998795429555124 0.999882258096533 855 863.272727272727 867 0.48939716673025 799 0.190985094621775 -0.169418263555487 -1 1.18132133267053e-05 853 898 799 800 867 867 852 865 915 880 900 918 M18767 GO_TYPE_I_INTERFERON_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_I_INTERFERON_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). 2/17 Gene Ontology MF GO:0005132 0.968631206393604 0.973924273095208 815 851.6 874 0.319318100909958 691 0.0484716197181263 -0.0239968982527641 -1 0.000739127661855431 812 865 811 NA 902 887 691 845 919 883 901 919 M19065 GO_TBP_CLASS_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TBP_CLASS_PROTEIN_BINDING.html Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). 9/25 Gene Ontology MF GO:0017025 0.777245711666946 0.790128237274685 915 832.181818181818 875 0.139437123354542 622 0.380353983170169 -0.380353983170169 -1 0.0517901000339453 849 911 886 751 882 622 875 823 912 902 741 920 M19181 GO_ODORANT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODORANT_BINDING.html Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell. 6/293 Gene Ontology MF GO:0005549 0.999982234016941 0.999982234016941 920 880.727272727273 910 0.665066240423491 763 0.115502675362982 0.108469445469232 1 0 763 920 910 812 912 891 829 913 920 916 902