Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M19114 GO_CELL_ADHESION_MOLECULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MOLECULE_BINDING.html Interacting selectively and non-covalently with a cell adhesion molecule. 97/272 Gene Ontology MF GO:0050839 1.20393336224616e-18 2.21523738653294e-16 5 33.8181818181818 18 1.09448487476924e-19 5 2.02696524147531 2.09327051057665 1 62.2917763883225 5 6 5 22 72 10 18 83 114 5 32 2 M18984 GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON.html The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 53/144 Gene Ontology MF GO:0005200 1.15290753451963e-08 3.78812475627877e-07 20 22.1818181818182 20 1.04809776414675e-09 2 2.47111308265446 2.8193233590216 1 31.1513756074049 20 9 24 2 20 23 15 31 21 59 20 3 M18158 GO_EXTRACELLULAR_MATRIX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_BINDING.html Interacting selectively and non-covalently with a component of the extracellular matrix. 43/88 Gene Ontology MF GO:0050840 3.79818071089906e-12 2.68794327232856e-10 5 46.1818181818182 21 3.45289155536874e-13 2 2.22229962932492 2.27678902781827 1 41.7526330430844 2 11 12 74 184 3 29 56 97 19 21 4 M18138 GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT.html The action of a molecule that contributes to the structural integrity of the extracellular matrix. 34/94 Gene Ontology MF GO:0005201 4.01080931782682e-14 3.68994457240068e-12 5 48 27 3.64619028893353e-15 1 2.33779917999595 2.38997869084346 1 52.4698295388653 1 58 9 27 269 5 14 59 46 13 27 5 M18089 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 3/11 Gene Ontology MF GO:0016813 2.96048612309571e-06 1.34169814445717e-05 30 110.909090909091 28 2.96049006711824e-07 8 2.74486198404607 -2.74486198404607 -1 26.2543675793366 28 28 663 52 243 17 24 23 8 94 40 6 M18391 GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE.html The action of a molecule that contributes to the structural integrity of a muscle fiber. 27/67 Gene Ontology MF GO:0008307 1.28542668786638e-07 2.81704805097631e-06 20 34.7272727272727 28 1.16856978451993e-08 8 2.31790079647236 2.47137771933714 1 25.2549741350352 16 15 46 28 8 16 21 40 55 89 48 7 M19121 GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 14/31 Gene Ontology MF GO:0008191 2.86409558570632e-07 3.81879411427509e-06 5 42 32 2.60372359870182e-08 1 2.29814679096881 2.40792152581942 1 24.4436287250179 6 42 37 54 133 1 2 118 32 26 11 8 M18839 GO_GLYCOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_BINDING.html Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 64/193 Gene Ontology MF GO:0001948 1.60348068387495e-07 3.1081770280229e-06 35 62.4545454545455 36 1.45770981885949e-08 15 1.9372226873923 2.12126763284077 1 20.9448184202033 18 35 31 95 149 15 57 36 160 56 35 9 M18439 GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. 31/148 Gene Ontology MF GO:0004867 1.90776260023261e-12 1.54960465747271e-10 15 36.6363636363636 37 1.73432963657661e-13 8 2.25522392003708 2.26354262752764 1 43.4302068629297 15 13 10 50 81 13 37 51 74 8 51 10 M18114 GO_COLLAGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_BINDING.html Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 43/105 Gene Ontology MF GO:0005518 1.58533552112034e-11 1.04179191387908e-09 40 74.5454545454545 40 1.44121411011979e-12 3 2.3118135355877 2.4434157756873 1 40.7642488376616 3 56 13 88 320 21 40 71 131 40 37 11 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 35/85 Gene Ontology MF GO:0019199 1.16782419423573e-06 7.61984580636079e-06 10 65.8181818181818 41 1.06165892195577e-07 6 1.82926715296229 1.84266339356638 1 18.3791314711754 10 235 44 31 109 6 11 41 163 61 13 12 M18157 GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY.html Combining with a neuropeptide to initiate a change in cell activity. 3/49 Gene Ontology MF GO:0008188 4.88484542096178e-07 4.93852504097235e-06 10 117.272727272727 41 4.88484649473928e-08 8 2.20961499713139 2.20961499713139 1 23.0175883055734 41 122 678 96 62 26 9 33 13 202 8 13 M18331 GO_MACROLIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROLIDE_BINDING.html Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. 9/18 Gene Ontology MF GO:0005527 2.76420435881626e-07 3.7799829111349e-06 15 107.909090909091 41 2.76420470265347e-08 6 1.62578878521041 1.77590189784079 1 17.3064303180811 123 21 716 41 30 111 62 15 6 48 14 14 M18712 GO_FK506_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FK506_BINDING.html Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. 9/18 Gene Ontology MF GO:0005528 2.76420435881626e-07 3.7799829111349e-06 15 116.454545454545 42 2.76420470265347e-08 7 1.62578878521041 1.77590189784079 1 17.3064303180811 124 22 801 42 31 112 63 14 7 50 15 15 M18873 GO_PEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 60/252 Gene Ontology MF GO:0030414 3.41686025109941e-10 1.65447970053235e-08 40 54.9090909090909 43 3.10623659239099e-11 8 2.13336320743241 2.1874507737122 1 32.5883305891292 38 8 18 93 134 24 81 50 100 15 43 16 M18166 GO_NITRIC_OXIDE_SYNTHASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_SYNTHASE_BINDING.html Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. 15/45 Gene Ontology MF GO:0050998 1.59529227740467e-07 3.1081770280229e-06 45 67.6363636363636 44 1.45026581189505e-08 11 3.70820474346144 4.12833771005572 1 40.092280403691 43 222 76 19 11 31 58 90 12 138 44 17 M18258 GO_GLYCOSAMINOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSAMINOGLYCAN_BINDING.html Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 95/306 Gene Ontology MF GO:0005539 1.53319507298503e-25 7.05269733573116e-23 5 47.5454545454545 44 1.39381370271367e-26 1 2.29959322277731 2.43696559567676 1 100 4 32 2 1 79 44 111 96 104 4 46 18 M18565 GO_INTEGRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_BINDING.html Interacting selectively and non-covalently with an integrin. 64/163 Gene Ontology MF GO:0005178 1.98782907607465e-11 1.21920183332579e-09 15 78.4545454545455 44 1.80711734190238e-12 11 2.01451041403669 2.0163784133387 1 35.2518135250369 11 34 14 61 191 30 44 188 197 30 63 19 M18457 GO_GROWTH_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_ACTIVITY.html The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 57/168 Gene Ontology MF GO:0008083 5.85716581120313e-11 2.99366252572604e-09 25 65.4545454545455 48 5.32469619214459e-12 16 2.19968200282547 2.29403569773339 1 36.8074735806902 24 129 17 82 105 25 48 158 94 16 22 20 M19086 GO_EPHRIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_ACTIVITY.html Combining with an ephrin to initiate a change in cell activity. 11/20 Gene Ontology MF GO:0005003 6.17417934941708e-06 2.26304581731622e-05 30 118.272727272727 48 5.61290606998264e-07 12 2.38197508754482 2.38197508754482 1 21.7217396488137 29 374 148 237 228 27 12 48 41 131 26 21 M18852 GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with platelet-derived growth factor. 11/23 Gene Ontology MF GO:0048407 3.19308712379317e-05 8.39620330288348e-05 50 110.818181818182 49 2.90284860845891e-06 8 2.47529310143029 2.47529310143029 1 19.8059176576444 8 182 47 112 439 40 45 147 49 46 104 22 M18486 GO_SCAFFOLD_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAFFOLD_PROTEIN_BINDING.html Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. 34/84 Gene Ontology MF GO:0097110 9.7867165897952e-09 3.33473306022651e-07 55 50.5454545454545 52 8.89701512121041e-10 3 1.90730662766116 2.32455896205958 1 24.2512048646508 49 60 43 5 129 56 52 3 54 55 50 23 M17981 GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 37/157 Gene Ontology MF GO:0022843 4.98406198418252e-07 4.98406198418252e-06 45 56.4545454545455 53 4.53096646664864e-08 13 1.8580297793042 2.00648835664989 1 19.3405808966219 42 59 45 13 53 85 61 28 119 25 91 24 M19199 GO_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 83/222 Gene Ontology MF GO:0019838 1.43799271635661e-07 3.07663557918159e-06 55 83.0909090909091 54 1.30726619122598e-08 23 1.93885891341758 2.03011022314155 1 20.9793691166431 23 128 30 56 180 54 172 35 153 31 52 25 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 26/67 Gene Ontology MF GO:0004714 5.82548341462524e-07 5.27983151316154e-06 10 63.3636363636364 55 5.29589541562086e-08 9 1.92919959410282 1.87717574811302 1 19.98658172625 14 217 55 29 67 9 10 81 135 64 16 26 M17957 GO_SULFUR_COMPOUND_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BINDING.html Interacting selectively and non-covalently with a sulfur compound. 124/344 Gene Ontology MF GO:1901681 3.49498491804535e-17 4.59340874943103e-15 20 63.5454545454545 58 3.17725901640486e-18 7 2.12763435449017 2.22637267377164 1 59.8858860952376 19 31 7 23 63 81 195 58 140 14 68 27 M17908 GO_CYTOSKELETAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). 431/1066 Gene Ontology MF GO:0008092 8.13088594496066e-09 2.87708271898608e-07 65 60.1818181818182 60 7.3917145227375e-10 14 1.76403462448163 1.98659734647614 1 22.6515235799701 65 48 23 60 33 14 70 72 186 62 29 28 M18015 GO_I_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_SMAD_BINDING.html Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. 10/18 Gene Ontology MF GO:0070411 4.88507840087381e-06 1.89018709369417e-05 60 141.363636363636 60 4.4409902256147e-07 23 1.85743897739738 1.85743897739738 1 17.2234850993215 60 382 279 80 213 57 23 39 47 318 57 29 M18092 GO_HEPARIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARIN_BINDING.html Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 76/236 Gene Ontology MF GO:0008201 1.76144742312515e-22 4.05132907318785e-20 10 58.3636363636364 63 1.60131583920468e-23 4 2.28950667101604 2.38633530402952 1 87.1598614695522 7 33 4 21 86 63 134 108 108 6 72 30 M18544 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. 43/147 Gene Ontology MF GO:0015085 3.86163897014749e-07 4.49709854751353e-06 40 73.2727272727273 64 3.51058149816132e-08 12 1.77163990565301 1.92430104682055 1 18.5966247801408 40 12 64 37 40 65 121 87 216 51 73 31 M18165 GO_CALCIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_BINDING.html Interacting selectively and non-covalently with calcium ions (Ca2+). 266/853 Gene Ontology MF GO:0005509 1.04647386450869e-22 3.20918651782666e-20 5 87.9090909090909 66 9.51339876826082e-24 2 1.93536480034957 2.03805423670442 1 74.0624377073209 53 110 3 73 13 50 150 214 233 2 66 32 M19034 GO_LAMININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMININ_BINDING.html Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. 20/43 Gene Ontology MF GO:0043236 5.35680223927597e-07 5.13360214597281e-06 30 75.2727272727273 66 4.86982140328146e-08 26 1.94889873635183 2.02735453115306 1 20.2373332292609 26 40 83 66 61 35 99 136 139 115 28 33 M18545 GO_INTERMEDIATE_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BINDING.html Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. 18/27 Gene Ontology MF GO:0019215 6.81583339739535e-08 1.73569879179076e-06 175 77.4545454545455 69 6.19621237141555e-09 3 2.70668368583166 3.0402486235285 1 30.6085403936672 175 17 42 3 4 173 106 160 29 74 69 34 M18961 GO_CHEMOREPELLENT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOREPELLENT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. 19/41 Gene Ontology MF GO:0045499 3.84703005664061e-06 1.64031886907568e-05 15 85.6363636363636 72 3.49730616706026e-07 4 2.00481188906987 2.14662100257246 1 18.8323744462029 12 151 72 89 304 11 4 30 120 139 10 35 M19217 GO_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 11/37 Gene Ontology MF GO:0005272 4.506065488012e-07 4.87603297698976e-06 70 96.8181818181818 75 4.09642400995438e-08 45 1.88260908666096 -1.84093842643588 -1 19.6316032859472 122 66 109 75 45 61 235 133 64 66 89 36 M17888 GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 46/210 Gene Ontology MF GO:0005244 2.30081885204558e-06 1.16649517611096e-05 80 80.7272727272727 77 2.09165568937e-07 27 1.86206014416434 2.0440556048405 1 18.0325906908968 77 96 48 45 156 89 68 97 109 27 76 37 M18656 GO_ION_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. 16/51 Gene Ontology MF GO:0022839 1.23573094260685e-07 2.81704805097631e-06 820 305.818181818182 77 1.12339182910668e-08 7 2.05952714110141 -2.02302708379101 -1 22.4398320813347 816 20 77 47 7 617 798 255 75 63 589 38 M17972 GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 56/188 Gene Ontology MF GO:0072509 2.43902877217537e-07 3.76504029521441e-06 80 92.7272727272727 78 2.21729912961655e-08 10 1.72974479579242 1.87774911626592 1 18.41887747124 58 10 81 78 23 78 151 130 260 65 86 39 M18672 GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). 12/36 Gene Ontology MF GO:0005343 5.20024632391396e-07 5.08960278510728e-06 70 171 78 4.7274977755652e-08 56 2.04940258474187 1.81296605475288 1 21.2960035406252 213 85 78 68 56 534 433 66 68 75 205 40 M18468 GO_FIBRONECTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRONECTIN_BINDING.html Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. 22/46 Gene Ontology MF GO:0001968 9.7101795361802e-07 7.11845079997341e-06 135 91.3636363636364 79 8.82743983816567e-08 4 1.91303488304578 1.99897958424462 1 19.3317827536773 35 132 65 135 186 43 53 105 168 79 4 41 M18556 GO_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 24/72 Gene Ontology MF GO:0043394 7.51112506568312e-09 2.87708271898608e-07 145 112.636363636364 79 6.82829553757018e-10 9 2.05067121259756 2.04548351261945 1 26.3321517105591 9 79 22 142 363 47 74 144 174 42 143 42 M18080 GO_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. 14/27 Gene Ontology MF GO:0016289 2.46485463586031e-06 1.20620546010185e-05 80 186.818181818182 80 2.24077945223578e-07 32 1.50571711594976 -1.09422263721089 -1 14.5387146338948 79 63 266 76 163 32 80 729 33 444 90 43 M18909 GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a potassium channel. 26/60 Gene Ontology MF GO:0015459 8.44094273874138e-07 6.60214443949097e-06 80 104.272727272727 80 7.67358725214309e-08 10 1.6742743555173 1.80693860045262 1 17.0265160514392 80 61 75 10 83 119 141 366 78 38 96 44 M19010 GO_FRIZZLED_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRIZZLED_BINDING.html Interacting selectively and non-covalently with the frizzled (fz) receptor. 17/44 Gene Ontology MF GO:0005109 8.21198414731018e-07 6.56958731784815e-06 285 158.727272727273 80 7.46544292055963e-08 4 2.33575756694583 2.32844622405214 1 23.7633072850525 283 19 53 4 80 455 479 153 43 69 108 45 M19157 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 13/56 Gene Ontology MF GO:0005245 1.01764158216037e-06 7.11845079997341e-06 115 84.2727272727273 83 9.25129138986724e-08 16 2.13237951275007 2.52377453077179 1 21.5483250594852 111 43 89 18 96 219 114 16 58 83 80 46 M18315 GO_POLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 10/23 Gene Ontology MF GO:0030247 4.25806829953359e-06 1.7309949905397e-05 25 113.636363636364 84 3.87097867362342e-07 3 1.80470000488284 1.80470000488284 1 16.8698193373865 21 136 94 206 263 12 3 27 386 84 18 47 M18397 GO_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). 544/1327 Gene Ontology MF GO:0032403 8.65429950170563e-07 6.63496295130765e-06 80 158.909090909091 88 8.65430287206798e-08 29 1.77612437420245 1.9817218912062 1 18.0547702154777 69 29 731 85 88 103 138 91 259 78 77 48 M18770 GO_TRANSCRIPTION_COACTIVATOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_BINDING.html Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 3/12 Gene Ontology MF GO:0001223 2.06405414308752e-05 5.86089448037198e-05 55 187 88 2.06407331477592e-06 46 1.72839984574344 -1.72839984574344 -1 14.3594095296605 88 123 813 150 403 46 55 55 65 203 56 49 M18654 GO_GLUCURONOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. 7/36 Gene Ontology MF GO:0015020 8.61302566782111e-08 2.08525884589353e-06 5 157 89 8.61302600165006e-09 3 2.20321993176306 2.20321993176306 1 24.5704670703872 50 250 792 58 143 109 89 4 3 223 6 50 M17875 GO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_BINDING.html Interacting selectively and non-covalently with a SMAD signaling protein. 49/113 Gene Ontology MF GO:0046332 1.04276377933145e-05 3.43850421858401e-05 30 116 91 9.47971565357168e-07 27 2.03029447341138 2.17720297558358 1 17.7905863888303 27 392 96 70 256 38 30 106 91 116 54 51 M18838 GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY.html Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. 11/31 Gene Ontology MF GO:0030159 2.80903690970419e-06 1.29494595912895e-05 45 172.545454545455 92 2.55367317853376e-07 9 1.91688437987081 2.20436974123147 1 18.3927961193169 92 503 251 191 475 45 19 43 40 230 9 52 M17943 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION.html Any protein binding that is involved in cell adhesion. 10/21 Gene Ontology MF GO:0098631 1.26104645413738e-06 7.8990748368896e-06 40 198.818181818182 93 1.14640652452135e-07 39 2.28631944002674 1.84055609785509 1 22.9011048350803 137 68 211 39 115 51 64 882 93 488 39 53 M18290 GO_SH3_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. 61/157 Gene Ontology MF GO:0017124 3.27784911926874e-07 4.24735378834822e-06 55 101.727272727273 93 2.97986327967807e-08 34 1.41761935410284 1.55017685687345 1 14.9495824342556 93 54 193 103 34 53 116 84 190 165 34 54 M18079 GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of metal ions from one side of a membrane to the other. 130/461 Gene Ontology MF GO:0046873 2.42942810704386e-11 1.39692116155022e-09 10 118.909090909091 96 2.2085710064279e-12 5 1.8363039156588 1.84962621422831 1 31.9203537825246 96 5 15 7 16 209 231 378 167 7 177 55 M18099 GO_WNT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_PROTEIN_BINDING.html Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. 18/33 Gene Ontology MF GO:0017147 3.65096283020802e-07 4.42506727776583e-06 155 81 100 3.31905766917806e-08 3 1.7076796464632 1.7076796464632 1 17.9487524659607 13 152 110 141 201 4 6 9 152 100 3 56 M18305 GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 4/20 Gene Ontology MF GO:0005328 5.6416207412165e-07 5.19029108191918e-06 45 137 101 5.64162217347182e-08 7 1.66561063290065 1.66561063290065 1 17.2800789268255 45 157 709 101 120 42 7 11 149 119 47 57 M18977 GO_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 35/126 Gene Ontology MF GO:0005267 1.94646953624422e-06 1.06055226959349e-05 185 110.727272727273 101 1.76951932582051e-07 16 1.78034570163979 1.83694931091429 1 17.3857718034443 98 77 58 16 142 181 154 174 184 33 101 58 M18211 GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY.html Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 117/1410 Gene Ontology MF GO:0004930 6.06565960237462e-07 5.37310027159109e-06 630 228.818181818182 102 5.51423752249927e-08 25 1.83728354895905 1.94153621405058 1 19.006898866197 25 628 35 626 178 72 82 165 533 102 71 59 M19041 GO_NOTCH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_BINDING.html Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. 8/30 Gene Ontology MF GO:0005112 1.25713132715151e-05 4.01583618395623e-05 440 318.363636363636 102 1.25713843891442e-06 24 2.40578603949697 3.0671270605586 1 20.7625080921656 436 102 876 63 336 796 653 42 24 95 79 60 M18554 GO_FILAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMIN_BINDING.html Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. 9/17 Gene Ontology MF GO:0031005 9.44877483524788e-06 3.19590913545149e-05 100 199.727272727273 103 9.44881501119394e-07 15 2.61706059801736 2.5419015621119 1 23.0954090946366 99 88 769 53 255 216 277 273 15 49 103 61 M17901 GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING.html Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. 15/23 Gene Ontology MF GO:0001965 2.59123006797424e-07 3.7799829111349e-06 140 90.5454545454545 104 2.35566397561602e-08 1 2.0965515178374 2.0965515178374 1 22.3176731978564 17 256 139 136 179 2 1 7 148 104 7 62 M18010 GO_RETINOIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_BINDING.html Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. 4/31 Gene Ontology MF GO:0001972 5.90622981063873e-09 2.36249192425549e-07 5 204.727272727273 105 5.90622982633632e-10 1 3.55389468427202 3.55389468427202 1 46.2317417804899 59 559 636 9 474 151 105 1 4 253 1 63 M19106 GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). 15/59 Gene Ontology MF GO:0015370 9.96969328259886e-07 7.11845079997341e-06 95 181.363636363636 106 9.06336163686043e-08 36 1.90877562625066 1.66593661240547 1 19.2887417050297 191 84 93 36 91 490 406 145 92 106 261 64 M18617 GO_ENZYME_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_INHIBITOR_ACTIVITY.html Binds to and stops, prevents or reduces the activity of an enzyme. 147/494 Gene Ontology MF GO:0004857 2.79390041257797e-07 3.7799829111349e-06 110 92.9090909090909 107 2.53990978853703e-08 4 1.75499693464831 1.87441498940759 1 18.6818438204763 107 4 34 110 28 137 257 120 151 32 42 65 M18075 GO_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_BINDING.html Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. 367/914 Gene Ontology MF GO:0019900 5.59141339965275e-07 5.19029108191918e-06 65 118.636363636364 109 5.08310438249072e-08 58 1.58904690921157 1.79625953127267 1 16.485759312433 103 109 90 152 64 58 148 162 227 127 65 66 M18060 GO_ACTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. 188/479 Gene Ontology MF GO:0003779 3.52779002538423e-08 1.01423963229797e-06 110 101.818181818182 110 3.20708189268525e-09 28 1.83850910773477 2.03860771487917 1 21.6329297060682 110 111 28 83 60 110 96 163 137 44 178 67 M18124 GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY.html Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 4/26 Gene Ontology MF GO:0015464 2.79093775244513e-05 7.52980273386956e-05 110 197.818181818182 112 2.79097280506564e-06 60 2.19083770560705 -2.19083770560705 -1 17.7332907845288 158 106 667 198 347 88 108 60 77 255 112 68 M18958 GO_MYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_BINDING.html Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. 48/108 Gene Ontology MF GO:0017022 6.98052774959327e-08 1.73569879179076e-06 85 290.090909090909 113 6.34593451916651e-09 5 2.07803214644619 2.51257700112029 1 23.4994325957743 486 55 50 84 5 569 345 819 82 113 583 69 M18700 GO_CORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 21/48 Gene Ontology MF GO:0015026 2.66440648779528e-06 1.25837303862175e-05 35 103 114 2.42219064967917e-07 19 1.69647604646292 1.7671772107575 1 16.3193818432872 22 163 114 139 169 19 28 32 292 122 33 70 M18989 GO_ALPHA_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_ACTININ_BINDING.html Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. 12/31 Gene Ontology MF GO:0051393 1.2548438785564e-06 7.8990748368896e-06 65 131.818181818182 114 1.14076781299938e-07 18 1.46808415424318 1.55469167325866 1 14.7051844355724 62 44 151 26 114 166 157 18 362 245 105 71 M19223 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. 38/152 Gene Ontology MF GO:0015081 4.18644861676544e-07 4.75497867583235e-06 40 370.818181818182 114 3.80586310310729e-08 35 1.94280242700433 -2.08761921321795 -1 20.3009322470435 912 114 39 35 42 519 916 623 106 37 736 72 M17907 GO_PEPTIDASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_REGULATOR_ACTIVITY.html Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 84/301 Gene Ontology MF GO:0061134 1.53655034193265e-08 4.87457349854495e-07 25 166.090909090909 115 1.39686395696764e-09 24 1.95839412510599 2.10938683383491 1 24.2669083041878 179 75 25 62 106 303 570 150 115 24 218 73 M18333 GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. 15/39 Gene Ontology MF GO:0005520 5.07288010231669e-07 5.01833300444232e-06 120 161.181818181818 117 4.61171024731769e-08 6 2.5644122080485 2.52122641650821 1 26.6784662843541 117 275 61 6 54 348 452 246 30 57 127 74 M18014 GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. 8/15 Gene Ontology MF GO:0010314 1.86579822935805e-07 3.4993711490565e-06 70 205.909090909091 118 1.8657983860122e-08 5 2.08027257310091 2.08027257310091 1 22.2811909641591 67 581 639 173 267 73 59 5 118 260 23 75 M19019 GO_NEUROTROPHIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neurotrophin receptor. 14/21 Gene Ontology MF GO:0005165 1.46449072820854e-06 8.806088038901e-06 130 124.636363636364 118 1.33135609371647e-07 18 2.11677238716732 2.25413966040952 1 21.0066578981675 115 311 118 34 126 184 187 80 18 128 70 76 M19194 GO_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. 80/319 Gene Ontology MF GO:0005261 3.43362575916483e-09 1.43587986292347e-07 70 108.090909090909 119 3.12147796774894e-10 10 1.93585224367949 1.99035216892807 1 26.004843906626 68 76 21 57 119 130 171 239 145 10 153 77 M18540 GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of potassium ions (K+) from one side of a membrane to the other. 45/152 Gene Ontology MF GO:0015079 6.75753731495923e-07 5.66789036269149e-06 180 142.363636363636 120 6.14321762782783e-08 17 1.71433190888802 1.73610752088733 1 17.6568850168274 120 36 60 17 74 231 184 455 176 34 179 78 M17890 GO_PROTEIN_KINASE_C_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_BINDING.html Interacting selectively and non-covalently with protein kinase C. 41/75 Gene Ontology MF GO:0005080 6.83843293759517e-07 5.66789036269149e-06 20 134.454545454545 123 6.21675914839996e-08 12 1.64017368598652 1.59906098229681 1 16.8930870526301 46 360 131 180 123 20 20 12 301 269 17 79 M18314 GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY.html Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. 7/11 Gene Ontology MF GO:0005092 4.00405374219521e-08 1.0856563800548e-06 190 167.545454545455 124 4.00405381434122e-09 2 1.6645047481296 1.76726704703879 1 19.4889334596227 186 24 713 111 2 257 160 20 34 124 212 80 M18982 GO_HISTONE_ACETYLTRANSFERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_ACETYLTRANSFERASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone acetyltransferase. 18/38 Gene Ontology MF GO:0035035 4.69894866516159e-06 1.85024700336877e-05 125 154.636363636364 125 4.27178063782648e-07 97 2.57633813599771 2.70363606007015 1 23.9365353176682 102 301 136 202 209 121 97 125 110 191 107 81 M19115 GO_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 707/2125 Gene Ontology MF GO:0005102 8.67095222797961e-17 9.97159506217655e-15 5 181.818181818182 126 8.67095222797962e-18 1 1.74686310500594 1.92279138498913 1 48.0140378110277 89 1 896 40 37 141 260 180 229 1 126 82 M18082 GO_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. 82/349 Gene Ontology MF GO:0022836 8.74073637125923e-10 4.02073873077924e-08 195 158.545454545455 128 7.94612397702904e-11 8 1.93480171752055 2.07766833463352 1 28.0904313042505 170 52 19 8 118 225 192 629 128 11 192 83 M18012 GO_STEROID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BINDING.html Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. 39/140 Gene Ontology MF GO:0005496 2.63621145477432e-07 3.7799829111349e-06 480 257.636363636364 130 2.39655615515071e-08 26 1.94482938801235 -1.71150470213457 -1 20.7025996372384 479 38 67 33 26 341 622 457 130 91 550 84 M18366 GO_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTININ_BINDING.html Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. 18/47 Gene Ontology MF GO:0042805 1.65012429020082e-06 9.57425414635067e-06 90 158.818181818182 130 1.50011411626232e-07 17 1.39575452191275 1.4441985335995 1 13.7518192978671 86 41 149 38 327 185 225 17 427 130 122 85 M18602 GO_DRUG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_BINDING.html Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 65/211 Gene Ontology MF GO:0008144 2.32959551908469e-07 3.76504029521441e-06 145 156.272727272727 130 2.11781433251568e-08 21 1.86338606106188 1.81315405754783 1 19.8419325421152 143 174 63 121 21 160 130 489 253 68 97 86 M18707 GO_CHEMOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_BINDING.html Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 12/31 Gene Ontology MF GO:0019956 6.71352575344926e-06 2.4125084417245e-05 15 213.181818181818 130 6.10322385504503e-07 12 2.60051167373587 2.60051167373587 1 23.5728255882544 48 467 130 263 531 22 13 70 411 378 12 87 M18156 GO_MHC_CLASS_II_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_RECEPTOR_ACTIVITY.html Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 5/10 Gene Ontology MF GO:0032395 5.21522901911589e-06 1.96975944066211e-05 135 159.181818181818 131 5.21524125853249e-07 26 2.7645583705318 2.89119312762698 1 25.5377454922391 131 26 677 64 223 150 39 134 71 90 146 88 M18553 GO_ION_CHANNEL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_CHANNEL_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. 68/168 Gene Ontology MF GO:0044325 1.65468087964104e-06 9.57425414635067e-06 90 207.727272727273 131 1.50425647652148e-07 64 1.44493200065303 1.56406785219989 1 14.2363456205697 90 215 103 216 131 64 84 622 543 77 140 89 M18689 GO_CHOLESTEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 4/18 Gene Ontology MF GO:0017127 3.00322965224908e-05 7.96245325668344e-05 85 206.454545454545 131 3.00327024026863e-06 11 3.48054419720966 3.48054419720966 1 28.0067750685775 81 253 798 11 430 165 131 85 23 258 36 90 M18703 GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 24/96 Gene Ontology MF GO:0005249 3.3745304022583e-06 1.47135922752494e-05 135 128.545454545455 131 3.0677596167141e-07 43 1.72085491258127 1.77135827750357 1 16.3244839791419 87 131 97 99 190 134 93 197 188 43 155 91 M18063 GO_ANION_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). 19/65 Gene Ontology MF GO:0015296 9.89720027154096e-07 7.11845079997341e-06 185 180.636363636364 134 8.99745884002214e-08 90 1.72258514650055 1.60244810121803 1 17.4072318825136 183 100 101 115 90 361 303 242 134 107 251 92 M17882 GO_CYTOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_BINDING.html Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 59/153 Gene Ontology MF GO:0019955 5.23881033149472e-05 0.00012518715597338 40 189.727272727273 135 4.76266826023771e-06 36 1.47708027652457 1.53173953586365 1 11.3157503514198 36 262 135 298 352 36 42 89 458 295 84 93 M17916 GO_PROTEIN_SELF_ASSOCIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SELF_ASSOCIATION.html Interacting selectively and non-covalently with a domain within the same polypeptide. 27/71 Gene Ontology MF GO:0043621 4.01220836107208e-08 1.0856563800548e-06 170 142.727272727273 136 3.64746221294905e-09 1 1.86985872969183 2.04406829884875 1 21.8933303870646 136 178 167 116 1 240 169 44 123 275 121 94 M18426 GO_COPPER_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_BINDING.html Interacting selectively and non-covalently with copper (Cu) ions. 27/68 Gene Ontology MF GO:0005507 2.12060021021604e-07 3.61287443221992e-06 140 260.090909090909 137 1.92781855874788e-08 18 2.04648851596308 -1.01468833056946 -1 21.8636462248031 439 98 73 137 18 811 520 117 81 137 430 95 M18509 GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 8/22 Gene Ontology MF GO:0099604 7.30088999778507e-07 5.89194631400199e-06 130 181.454545454545 140 7.30089239642094e-08 13 1.67523459944185 1.8886306128672 1 17.1988272151564 128 70 756 140 252 161 167 13 117 143 49 96 M18383 GO_RECEPTOR_AGONIST_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_AGONIST_ACTIVITY.html Interacts with receptors such that the proportion of receptors in the active form is increased. 8/18 Gene Ontology MF GO:0048018 4.34047215764312e-05 0.000106770972861809 80 239.272727272727 142 4.34055693861721e-06 76 2.01811185816054 -2.35281736703111 -1 15.7343178290559 152 249 729 131 555 118 279 76 76 142 125 97 M18192 GO_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASE_BINDING.html Interacting selectively and non-covalently with any protease or peptidase. 60/192 Gene Ontology MF GO:0002020 1.59339297656335e-06 9.33707986266419e-06 100 351.727272727273 144 1.44854011873682e-07 96 1.62894070139447 -1.20559973124591 -1 16.0841470528022 843 113 144 97 130 386 702 356 96 126 876 98 M17965 GO_TAU_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_BINDING.html Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. 12/20 Gene Ontology MF GO:0048156 0.000132207121015906 0.000279610462838237 130 240.909090909091 145 1.20195515053098e-05 53 2.23503484105175 2.70264919050411 1 15.5911118942411 126 531 181 200 702 145 67 138 132 375 53 99 M18238 GO_STEROID_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_ACTIVITY.html Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. 19/63 Gene Ontology MF GO:0003707 1.97935071590704e-05 5.69063330823274e-05 150 172.454545454545 147 1.79942593131469e-06 67 1.58086296669342 -1.66162729613506 -1 13.1734184881344 147 180 170 134 296 146 298 67 212 108 139 100 M18174 GO_THIOLESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOLESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. 24/40 Gene Ontology MF GO:0016790 2.10974113948635e-06 1.12194326492916e-05 45 179.363636363636 148 1.91794832970398e-07 7 1.3277962809156 -1.04976153671503 -1 12.9027475291628 44 218 326 159 148 7 33 406 88 520 24 101 M17988 GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). 5/19 Gene Ontology MF GO:0005283 2.37707458723497e-07 3.76504029521441e-06 80 176.363636363636 149 2.37707484150677e-08 8 1.66561063290065 1.66561063290065 1 17.7359563275689 76 260 630 164 172 116 90 8 194 149 81 102 M19111 GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY.html Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 5/27 Gene Ontology MF GO:0005326 1.92556721637239e-06 1.06055226959349e-05 55 219 150 1.92556888488852e-07 8 1.66561063290065 1.66561063290065 1 16.2653389952736 55 252 894 245 150 71 8 38 425 155 116 103 M18222 GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS.html The action of a molecule that contributes to the structural integrity of the lens of an eye. 5/22 Gene Ontology MF GO:0005212 2.54339322244704e-06 1.23092829908806e-05 95 171.909090909091 151 2.54339613343382e-07 24 1.52927205232143 1.67256551234534 1 14.7397003771294 104 27 692 221 175 91 92 24 162 151 152 104 M18777 GO_MICROTUBULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BINDING.html Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. 102/252 Gene Ontology MF GO:0008017 2.2435056544921e-06 1.15956472029929e-05 65 277.545454545455 153 2.0395526748791e-07 64 1.58025710211351 1.82119176379288 1 15.311577810397 64 472 352 592 153 98 78 143 314 652 135 105 M18123 GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. 20/60 Gene Ontology MF GO:0015179 2.07532957600895e-06 1.11006000577223e-05 115 263.727272727273 154 1.88666503066869e-07 80 2.03076435066068 2.25187906144695 1 19.75221584975 433 179 124 114 146 695 573 154 80 114 289 106 M19099 GO_PURINERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_ACTIVITY.html Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 10/26 Gene Ontology MF GO:0035586 2.02721465115985e-05 5.79204186045673e-05 115 185.636363636364 154 1.84293939217945e-06 78 2.4252421335776 2.4252421335776 1 20.1731547574981 78 356 154 314 298 106 115 193 113 198 117 107 M18349 GO_SIGNALING_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_RECEPTOR_ACTIVITY.html Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 304/2031 Gene Ontology MF GO:0038023 2.96686292511522e-18 4.54918981851001e-16 35 155.090909090909 156 2.69714811374111e-19 6 1.81781343042028 1.8504551248797 1 54.7489953734614 34 201 6 305 58 115 156 256 393 17 165 108 M18662 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. 5/31 Gene Ontology MF GO:0043395 8.73724539033526e-05 0.000197500387201682 180 222.454545454545 157 8.73758893690241e-06 20 1.3827710587821 1.26762446413696 1 10.0557602947044 177 47 794 20 379 244 109 157 73 152 295 109 M18235 GO_ANTIOXIDANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIOXIDANT_ACTIVITY.html Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. 31/82 Gene Ontology MF GO:0016209 1.12953479104763e-06 7.43316690352892e-06 115 220.727272727273 158 1.02685033725395e-07 68 1.60161026298933 -1.48037966068523 -1 16.1256718593001 112 148 158 378 107 68 127 387 431 267 245 110 M18141 GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. 5/14 Gene Ontology MF GO:0015172 5.58082598155617e-05 0.000132328863480198 115 246.909090909091 159 5.58096614179406e-06 66 2.68348100124955 2.68348100124955 1 20.430924140641 114 377 672 247 483 136 77 86 66 299 159 111 M19073 GO_RECEPTOR_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_REGULATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. 24/55 Gene Ontology MF GO:0030545 9.4061455404057e-06 3.19323022035913e-05 320 255.818181818182 160 8.55107796074218e-07 69 1.660801283806 1.32129608960996 1 14.6576630553023 318 99 153 69 248 309 143 765 103 160 447 112 M18088 GO_ACTIN_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BINDING.html Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. 70/170 Gene Ontology MF GO:0051015 6.71167762095957e-07 5.66789036269149e-06 425 243.909090909091 161 6.10152697139447e-08 12 1.89832638473902 -1.56792577371537 -1 19.5519493883837 425 161 68 12 73 552 299 388 86 81 538 113 M18251 GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a monosaccharide from one side of a membrane to the other. 7/25 Gene Ontology MF GO:0015145 0.000213604141515723 0.000426281583935933 55 215.181818181818 161 2.13624676321952e-05 50 1.95596995661996 1.95596995661996 1 12.9411890384509 52 142 698 161 420 80 50 199 207 220 138 114 M18024 GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING.html A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors. 16/51 Gene Ontology MF GO:0098531 3.96601027142906e-05 9.94204209731536e-05 165 188.363636363636 162 3.60552888160685e-06 117 1.77223041429392 -1.89866076892767 -1 13.9250631447411 121 119 210 117 340 162 326 159 165 162 191 115 M18068 GO_PROTEIN_KINASE_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_BINDING.html Interacting selectively and non-covalently with any subunit of protein kinase A. 18/48 Gene Ontology MF GO:0051018 2.41420670493692e-05 6.68997038717461e-05 65 208.909090909091 163 2.19475745276728e-06 45 1.59936345967156 1.59936345967156 1 13.1069764887489 63 520 283 163 309 75 66 152 221 401 45 116 M18408 GO_ADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_BINDING.html Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. 26/67 Gene Ontology MF GO:0043531 0.000103066965227959 0.00022738994726552 165 213.090909090909 163 9.37016309907486e-06 31 2.95476546873288 3.48880184968462 1 21.1325767277037 95 514 163 165 383 144 104 99 31 451 195 117 M18680 GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. 59/148 Gene Ontology MF GO:0008194 7.27255788838942e-07 5.89194631400199e-06 175 148.090909090909 166 6.61141844771446e-08 21 1.86403588189678 1.97060639314428 1 19.1371591086178 106 263 173 166 76 259 173 21 79 146 167 118 M18745 GO_ACTIVIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_BINDING.html Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits. 5/16 Gene Ontology MF GO:0048185 0.000574059872688216 0.00102950308552273 40 261.636363636364 166 5.74208221758357e-05 39 1.65272812123857 1.65272812123857 1 9.69245450983902 39 304 806 259 521 138 161 148 166 153 183 119 M18498 GO_CALMODULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_BINDING.html Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. 71/244 Gene Ontology MF GO:0005516 2.55551418615021e-06 1.23092829908806e-05 170 180.545454545455 167 2.32319741330324e-07 72 1.84149516207874 1.72092171888097 1 17.7490243961795 72 421 111 179 165 77 133 170 272 167 219 120 M18571 GO_FERROUS_IRON_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERROUS_IRON_BINDING.html Interacting selectively and non-covalently with ferrous iron, Fe(II). 15/29 Gene Ontology MF GO:0008198 9.53997421777871e-08 2.25045545650164e-06 195 135.454545454545 167 8.67270421042326e-09 6 2.25540979877312 2.05631851671616 1 25.0058923677719 248 167 194 48 6 192 17 313 26 215 64 121 M18337 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. 28/79 Gene Ontology MF GO:0015171 2.77074310497021e-06 1.28741598816797e-05 170 216.727272727273 171 2.51886054048155e-07 93 1.8692876327715 1.96287186733262 1 17.945392290779 259 236 137 168 174 483 365 169 129 93 171 122 M19054 GO_DOPAMINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a dopamine receptor. 9/31 Gene Ontology MF GO:0050780 5.22414460349515e-06 1.96975944066211e-05 190 212.090909090909 171 5.22415688479487e-07 25 2.04307372864851 -1.99049759854879 -1 18.8729951918406 188 46 880 25 224 170 262 219 28 171 120 123 M19159 GO_CYTOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_ACTIVITY.html Functions to control the survival, growth, differentiation and effector function of tissues and cells. 70/239 Gene Ontology MF GO:0005125 3.82205963622817e-11 2.06840874431171e-09 445 341.454545454545 172 3.4745996693587e-12 16 2.08631093115679 2.14612389298765 1 35.5680482772598 441 146 16 157 122 824 576 828 172 21 453 124 M17979 GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 121/397 Gene Ontology MF GO:0015077 1.00800638381465e-06 7.11845079997341e-06 690 270.727272727273 173 9.16369859698241e-08 28 1.76823261255959 -1.70350146031006 -1 17.8685130171791 690 124 52 46 92 264 662 327 173 28 520 125 M18288 GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING.html Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. 23/59 Gene Ontology MF GO:0050431 3.04257591238559e-06 1.3674858581274e-05 160 174 174 2.76598192749355e-07 74 1.44807212573809 1.38757564494363 1 13.8271810180168 157 247 174 199 182 124 152 128 270 207 74 126 M18336 GO_TROPOMYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPOMYOSIN_BINDING.html Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. 6/14 Gene Ontology MF GO:0005523 1.00032225468193e-05 3.3280641370573e-05 175 217.545454545455 175 1.00032675761121e-06 83 2.36164293591102 2.36164293591102 1 20.759779412721 83 143 717 187 258 174 123 210 146 177 175 127 M18452 GO_CYCLIC_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 9/43 Gene Ontology MF GO:0030551 2.16823603188172e-06 1.14642364904091e-05 35 195.636363636364 175 2.168238147446e-07 19 1.57696926736959 1.57696926736959 1 15.2950445409131 33 333 743 178 295 28 32 19 175 286 30 128 M18900 GO_PROTEIN_TYROSINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_BINDING.html Interacting selectively and non-covalently with protein tyrosine kinase. 39/84 Gene Ontology MF GO:1990782 8.7937680274135e-06 3.03006239146832e-05 115 187.181818181818 176 7.99436652524734e-07 38 2.07402421708585 2.32288696288161 1 18.3973709194488 207 176 115 122 245 302 396 151 38 111 196 129 M18590 GO_NEUROPILIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPILIN_BINDING.html Interacting selectively and non-covalently with a member of the neuropilin family. 6/15 Gene Ontology MF GO:0038191 0.000164932607770254 0.000343298640607769 35 230.545454545455 180 1.64944850293392e-05 22 1.48444521505667 1.48444521505667 1 10.0954612432204 32 169 775 186 429 34 22 213 435 180 61 130 M18800 GO_SOLUTE_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). 42/113 Gene Ontology MF GO:0015294 1.07173745662124e-06 7.30369229697438e-06 125 347.636363636364 180 9.74307253383754e-08 37 1.68165583855234 1.70477690829429 1 16.9567970033104 393 37 121 153 99 687 670 862 180 125 497 131 M19120 GO_SEMAPHORIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with semaphorin receptors. 10/29 Gene Ontology MF GO:0030215 0.00413229608268384 0.0065321518832803 35 247.727272727273 180 0.000376370755853274 31 2.07722822379705 2.07722822379705 1 8.90979000975773 31 381 107 170 599 152 122 258 403 322 180 132 M19145 GO_PROTEIN_PHOSPHATASE_2A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_2A_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. 16/44 Gene Ontology MF GO:0051721 1.68711981131413e-05 5.07238636081372e-05 50 247.272727272727 180 1.53375704501209e-06 46 2.24505556308582 2.60347319575462 1 18.9283079078738 180 605 272 204 462 140 83 46 50 618 60 133 M18623 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other. 55/171 Gene Ontology MF GO:0005342 2.81509991114988e-06 1.29494595912895e-05 40 253.454545454545 181 2.55918501212043e-07 36 1.99849232093419 1.95221319495388 1 19.1758366852054 330 147 38 129 181 639 535 240 169 36 344 134 M19050 GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. 80/201 Gene Ontology MF GO:0005057 3.25249433090547e-06 1.43860326174665e-05 240 196.272727272727 183 2.95681739947657e-07 53 1.37045360268718 1.47532525191454 1 13.026789918285 236 53 218 183 188 172 162 496 246 73 132 135 M18621 GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR.html Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. 6/11 Gene Ontology MF GO:0016884 4.21728318088887e-05 0.000104298401247789 85 264.727272727273 184 4.21736321767504e-06 75 1.26280445332662 -1.26280445332662 -1 9.87074825334962 84 284 779 306 518 92 139 75 111 340 184 136 M18812 GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. 10/35 Gene Ontology MF GO:0005217 3.11000552422014e-06 1.38893450596239e-05 155 188.909090909091 185 2.82728174604868e-07 54 1.67523459944185 1.8886306128672 1 15.9740555941188 154 69 205 218 185 238 177 54 450 195 133 137 M17993 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 12/39 Gene Ontology MF GO:0001205 0.000217922256113147 0.000433020465710789 480 266.090909090909 189 1.98130768655165e-05 75 2.04715066025219 2.04715066025219 1 13.5170882598881 75 486 189 478 514 97 118 115 478 243 134 138 M18747 GO_BETA_AMYLOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_BINDING.html Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. 14/39 Gene Ontology MF GO:0001540 3.27474763406988e-06 1.44139983924724e-05 175 268.909090909091 189 2.97704773510254e-07 39 1.65664298257536 2.00577043885539 1 15.744408261999 276 166 247 172 189 541 786 63 39 307 172 139 M18842 GO_MYOSIN_V_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_V_BINDING.html Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. 9/22 Gene Ontology MF GO:0031489 2.35234788548482e-06 1.17584608956251e-05 170 329.090909090909 189 2.35235037558178e-07 89 1.60493834125661 -1.65779485206476 -1 15.5316428593848 579 89 827 138 167 324 673 179 189 170 285 140 M18867 GO_NF_KAPPAB_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NF_KAPPAB_BINDING.html Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. 19/42 Gene Ontology MF GO:0051059 1.46319433765924e-06 8.806088038901e-06 110 264.636363636364 190 1.33017755528512e-07 5 0.794023259657574 -0.641917820441736 -1 7.87981502051016 108 190 453 442 365 8 41 53 592 654 5 141 M19061 GO_GAMMA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_CATENIN_BINDING.html Interacting selectively and non-covalently with the gamma subunit of the catenin complex. 7/21 Gene Ontology MF GO:0045295 4.55836424804739e-06 1.81545242779377e-05 155 220.363636363636 190 4.55837359848247e-07 5 2.23101765886038 2.81368010528267 1 20.7643025950957 153 140 884 90 216 206 76 237 5 227 190 142 M18528 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the transforming growth factor beta receptor. 20/59 Gene Ontology MF GO:0005160 4.78035435405673e-05 0.000116040264003488 195 219.272727272727 193 4.34587111725378e-06 85 1.81736454554875 1.96238551235332 1 14.0401895469783 193 397 164 91 349 374 256 113 85 234 156 143 M18575 GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 176/580 Gene Ontology MF GO:0022890 3.52976243072275e-07 4.42506727776583e-06 50 347 193 3.20887545186472e-08 20 1.75747009257978 1.84962621422831 1 18.47208036248 583 50 33 30 50 820 700 728 193 20 610 144 M17870 GO_SIGNAL_TRANSDUCER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCER_ACTIVITY.html Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 472/2441 Gene Ontology MF GO:0004871 8.02039352114802e-15 8.19862448828465e-13 10 171.909090909091 194 7.29126683740731e-16 8 1.64709390954005 1.71629416666268 1 39.0798834117011 82 108 8 278 29 194 197 367 377 9 242 145 M18216 GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of cation from one side of the membrane to the other. 221/681 Gene Ontology MF GO:0008324 1.02134294086575e-06 7.11845079997341e-06 630 352.181818181818 195 9.28494013655673e-08 23 1.70369736367207 1.82903927144196 1 17.2163652551488 627 49 36 65 121 757 719 614 195 23 668 146 M17964 GO_CARBOHYDRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BINDING.html Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. 102/328 Gene Ontology MF GO:0030246 1.71547784624998e-06 9.86399761593738e-06 105 200.909090909091 196 1.55952653083364e-07 87 1.63255159701425 1.74091068542534 1 16.043390951962 105 125 92 431 135 236 196 225 363 87 215 147 M18646 GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a carboxylic ester bond. 52/170 Gene Ontology MF GO:0052689 3.15698350900428e-07 4.1491783261199e-06 250 204.363636363636 196 2.86998542002648e-08 32 1.52703683360049 -1.55884518350465 -1 16.1338964122523 249 189 248 461 32 87 336 93 196 279 78 148 M17995 GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 4/15 Gene Ontology MF GO:0001608 0.000171363249234222 0.000352693935784082 150 245 197 1.71376465081996e-05 44 2.62445051366694 2.62445051366694 1 17.7880321989448 146 171 633 244 408 197 285 184 44 252 131 149 M19008 GO_PEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 21/145 Gene Ontology MF GO:0001653 0.000241958065908874 0.000477205297439606 55 240 197 2.19986073438403e-05 54 2.28538181403244 2.47056206041607 1 14.9007862518118 54 423 62 331 496 157 85 322 390 123 197 150 M18942 GO_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 8/22 Gene Ontology MF GO:0016502 0.000116890980215443 0.000250675295566918 100 283.272727272727 198 1.16897129246232e-05 96 2.46231791945969 2.46231791945969 1 17.4059124672563 97 433 859 417 394 96 98 198 141 264 119 151 M17913 GO_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLASE_ACTIVITY.html Catalysis of a ring closure reaction. 9/23 Gene Ontology MF GO:0009975 4.99644414793493e-05 0.000120966542528951 60 236.272727272727 200 4.99655649153351e-06 25 1.99573949804964 1.99573949804964 1 15.347496231132 57 154 617 268 355 48 25 200 536 284 55 152 M18196 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 11/29 Gene Ontology MF GO:0008519 2.84938605879373e-06 1.30355217594522e-05 135 249.545454545455 200 2.59035431750489e-07 74 1.74279136592491 -1.74279136592491 -1 16.712505013835 133 289 200 283 176 169 397 74 528 349 147 153 M19177 GO_STRUCTURAL_MOLECULE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_MOLECULE_ACTIVITY.html The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. 349/949 Gene Ontology MF GO:0005198 8.46796786804276e-07 6.60214443949097e-06 55 192.181818181818 200 7.69815557039089e-08 51 1.93833997364245 2.2502489996857 1 19.7119286878214 211 200 59 51 84 535 388 203 90 53 240 154 M18145 GO_ADRENERGIC_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an adrenergic receptor. 7/30 Gene Ontology MF GO:0031690 1.55333722963787e-05 4.74774169856093e-05 35 254.818181818182 201 1.55334808759916e-06 33 0.818880299332285 -0.818880299332285 -1 6.95024605845072 51 227 674 201 284 33 35 181 471 588 58 155 M18492 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein receptor. 8/20 Gene Ontology MF GO:0050750 3.47442316216178e-06 1.50776854207021e-05 130 370 204 3.47442859440107e-07 25 1.91552062356102 1.91552062356102 1 18.1312144411779 130 664 753 435 870 101 126 25 204 608 154 156 M18663 GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 68/213 Gene Ontology MF GO:0008514 4.4673388550681e-06 1.79473875400116e-05 395 285.363636363636 205 4.06122538773677e-07 39 1.76963089324732 1.87533682774297 1 16.4874431679539 391 160 51 130 205 733 498 280 192 39 460 157 M18151 GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. 131/498 Gene Ontology MF GO:0022803 2.02122346626875e-12 1.54960465747271e-10 15 226.636363636364 208 1.83747587842783e-13 11 1.9013513129294 1.98115028174441 1 36.6154686777988 221 93 11 55 108 360 329 864 208 12 232 158 M17918 GO_LIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of lipids into, out of or within a cell, or between cells. 49/169 Gene Ontology MF GO:0005319 4.79234299214868e-06 1.86820150541389e-05 560 316 212 4.3566849377473e-07 74 1.94864512073041 -1.7791352393031 -1 18.0886499325133 557 175 74 167 212 322 458 532 201 80 698 159 M18807 GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in). 2/12 Gene Ontology MF GO:0043225 0.00117843836448195 0.00203407747715459 140 324.1 212 0.00013100622559708 73 1.27104697192128 1.27104697192128 1 6.7161496018652 138 279 822 NA 547 127 73 172 695 136 252 160 M18948 GO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger to initiate a change in cell activity. 399/2329 Gene Ontology MF GO:0004872 4.29569264268814e-26 3.95203723127309e-23 5 190.272727272727 212 3.90517512971648e-27 1 1.82502856162304 1.79197703897341 1 80.2642802712911 71 91 1 297 52 212 247 507 374 3 238 161 M18578 GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a negatively charged ion from one side of a membrane to the other. 98/337 Gene Ontology MF GO:0008509 6.78427176541995e-07 5.66789036269149e-06 385 284.454545454545 213 6.16752168866124e-08 45 1.62038260148186 1.6985528765012 1 16.689247350673 385 94 54 128 75 660 512 579 213 45 384 162 M18065 GO_PEPTIDE_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for peptide hormones. 8/24 Gene Ontology MF GO:0051428 7.42237154142473e-06 2.61631487283937e-05 315 234.727272727273 214 7.42239633276095e-07 34 1.870753088855 2.23114148937991 1 16.8284430132053 314 156 658 49 242 276 214 34 36 417 186 163 M18686 GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY.html Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. 15/25 Gene Ontology MF GO:0042813 1.0827142925112e-05 3.53225939400819e-05 30 184.272727272727 215 9.84290564590006e-07 19 1.38998287572514 1.38998287572514 1 12.147935416908 37 221 215 350 334 29 27 62 516 217 19 164 M18232 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 44/118 Gene Ontology MF GO:0003705 0.00123139866709531 0.00211754537145362 170 339.363636363636 219 0.000112008041305148 59 1.57922521986693 1.64910342377098 1 8.29040292199982 66 689 219 671 497 59 102 168 542 552 168 165 M17969 GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. 13/29 Gene Ontology MF GO:0016411 8.04472989034489e-05 0.000183948805311428 220 272.272727272727 220 7.31365825152157e-06 87 1.85683281396626 -1.63733653983789 -1 13.6157522862983 220 476 292 517 471 100 87 94 183 407 148 166 M18059 GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. 6/19 Gene Ontology MF GO:0015269 1.13113409401527e-06 7.43316690352892e-06 25 357.636363636364 220 1.13113466977463e-07 15 2.161660800555 -1.76086531879907 -1 21.7644913998908 620 25 655 15 113 751 831 612 25 67 220 167 M18529 GO_WW_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WW_DOMAIN_BINDING.html Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. 16/34 Gene Ontology MF GO:0050699 1.19599109007101e-06 7.69893872062377e-06 105 400.272727272727 220 1.08726521840992e-07 11 2.32772253342861 -1.70004385868809 -1 23.3667516895301 904 220 105 102 110 608 594 756 11 163 830 168 M18611 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS.html Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). 14/33 Gene Ontology MF GO:0016769 7.58145093275696e-05 0.00017437337145341 315 241.818181818182 220 6.89246564619012e-06 59 1.99975931756773 2.42568536957486 1 14.7549443241615 313 355 186 220 369 376 205 92 59 199 286 169 M18598 GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY.html Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. 7/18 Gene Ontology MF GO:0005041 0.000558138504188071 0.00100514605098493 120 335.090909090909 221 5.58278737126665e-05 118 1.14240148762895 1.14240148762895 1 6.72295470655984 118 357 777 285 582 155 136 146 768 221 141 170 M18637 GO_ISOPRENOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BINDING.html Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 7/53 Gene Ontology MF GO:0019840 0.000351077622624929 0.000660514136635858 495 323.909090909091 222 3.51133099934358e-05 52 3.15254851655832 3.55389468427202 1 19.6810379242987 162 564 786 98 492 494 466 139 52 222 88 171 M19185 GO_CYTOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a cytokine receptor. 134/377 Gene Ontology MF GO:0005126 1.28038283155691e-06 7.9591365204889e-06 235 223.818181818182 223 1.16398506975485e-07 54 1.66862668846879 1.79043849823029 1 16.7031589608952 286 232 66 175 117 503 476 223 232 54 98 172 M19042 GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). 6/23 Gene Ontology MF GO:0005416 2.29550290675352e-07 3.76504029521441e-06 185 273.909090909091 225 2.29550314387356e-08 6 1.66561063290065 1.66561063290065 1 17.7359563275689 116 317 877 225 480 273 185 6 237 182 115 173 M18178 GO_CIS_TRANS_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_TRANS_ISOMERASE_ACTIVITY.html Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. 16/44 Gene Ontology MF GO:0016859 5.97872163157528e-06 2.22203747005e-05 230 259.818181818182 226 5.43521625401403e-07 86 1.76268054906159 1.96755036723245 1 16.1017422116977 333 135 227 86 226 648 508 190 89 112 304 174 M18632 GO_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BINDING.html Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. 22/96 Gene Ontology MF GO:0042562 5.05821028556147e-05 0.000121820771275302 150 285.727272727273 229 4.59847871544797e-06 88 2.2019192996295 -2.32958939988219 -1 16.9198355445874 434 150 88 105 350 443 729 229 147 103 365 175 M18284 GO_STEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BINDING.html Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. 18/56 Gene Ontology MF GO:0032934 4.55778845500419e-07 4.87603297698976e-06 610 297.090909090909 230 4.14344490841049e-08 18 1.58708977372963 -1.38454495470066 -1 16.5499662194021 607 18 171 104 46 354 718 384 230 129 507 176 M18061 GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. 37/89 Gene Ontology MF GO:0005546 6.5337566069212e-06 2.36189306785467e-05 770 375.909090909091 231 5.93979637412377e-07 100 2.1083013881987 -2.30570869966601 -1 19.1492058674445 769 273 127 100 231 846 580 173 124 161 751 177 M18236 GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 6/14 Gene Ontology MF GO:0004185 0.000241439139067505 0.000477205297439606 65 283.545454545455 231 2.41465374865391e-05 26 1.78691315736964 1.78691315736964 1 11.6507494708378 61 340 694 349 539 52 26 142 231 561 124 178 M17982 GO_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 83/232 Gene Ontology MF GO:0004713 1.52925960695327e-07 3.1081770280229e-06 165 206 232 1.39023610295897e-08 10 1.6511018536365 1.79795192169951 1 17.8513439447006 164 294 100 106 10 342 288 245 283 232 202 179 M18390 GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. 12/19 Gene Ontology MF GO:0071617 0.000242924527172075 0.000477543942304079 135 264.181818181818 232 2.2086486827632e-05 94 1.85683281396626 -1.63733653983789 -1 12.1055055827251 232 450 278 439 423 133 94 135 156 377 189 180 M18622 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. 10/17 Gene Ontology MF GO:0016646 0.00102041240038926 0.00177463026154653 195 293.363636363636 233 9.28078181388031e-05 35 1.7794041097713 1.6214031480352 1 9.60928659041843 290 192 233 171 488 380 179 697 35 192 370 181 M19079 GO_SODIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_BINDING.html Interacting selectively and non-covalently with sodium ions (Na+). 8/30 Gene Ontology MF GO:0031402 1.69739760238113e-05 5.08080375535743e-05 235 301.545454545455 234 1.6974105677343e-06 23 1.84340119355763 -1.84340119355763 -1 15.5393102983867 234 23 889 146 288 270 739 123 244 145 216 182 M19063 GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. 8/20 Gene Ontology MF GO:0004198 6.0932488594514e-06 2.24231558027811e-05 235 291.454545454545 235 6.09326556697261e-07 17 2.29957847165477 -1.62704298623159 -1 20.9883892443883 368 138 885 67 233 246 249 624 17 144 235 183 M19124 GO_EPHRIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ephrin receptor. 21/43 Gene Ontology MF GO:0046875 7.99547500472761e-06 2.79689619937239e-05 55 198.090909090909 239 7.26864005716799e-07 25 1.32490317140269 1.32490317140269 1 11.8428344852092 30 438 289 454 239 55 69 52 278 250 25 184 M18993 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the tumor necrosis factor receptor. 12/34 Gene Ontology MF GO:0005164 0.000563551434190989 0.00101263148331193 240 263.090909090909 240 5.12450768339346e-05 83 2.07203257472837 -1.64709780075758 -1 12.1806633357998 346 456 240 236 465 114 117 161 83 383 293 185 M19187 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 16/26 Gene Ontology MF GO:0016645 1.70648734826679e-05 5.08080375535743e-05 245 338.727272727273 241 1.5513641683859e-06 98 1.39175164333028 1.30414049048241 1 11.7320422033338 495 118 239 143 283 465 241 763 98 241 640 186 M18665 GO_WIDE_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WIDE_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. 13/27 Gene Ontology MF GO:0022829 0.00210991708238468 0.00351016946798174 160 279 242 0.000191994847842122 79 2.47882372782966 2.39550290432299 1 11.9448884217022 156 563 79 432 516 266 219 297 242 117 182 187 M18746 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 11/23 Gene Ontology MF GO:0016638 1.45778070400262e-06 8.806088038901e-06 585 367.636363636364 242 1.32525606360839e-07 71 2.06936196834989 2.64546353063887 1 20.5361611836832 584 87 71 242 125 787 884 290 202 97 675 188 M18624 GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY.html Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 5/14 Gene Ontology MF GO:0004467 8.07775188541489e-05 0.000183948805311428 245 318.545454545455 243 8.07804552577722e-06 101 1.16010977492305 -1.16010977492305 -1 8.50683332088154 243 211 780 351 371 188 158 413 101 526 162 189 M18041 GO_ANKYRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANKYRIN_BINDING.html Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. 12/49 Gene Ontology MF GO:0030506 4.16081704897425e-07 4.75497867583235e-06 785 402.818181818182 244 3.78256166900151e-08 37 2.2809991054159 -1.93007324286346 -1 23.8348520073618 785 238 155 148 41 884 591 398 37 244 910 190 M18978 GO_FATTY_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. 5/20 Gene Ontology MF GO:0015645 8.07775188541489e-05 0.000183948805311428 245 327.272727272727 244 8.07804552577722e-06 102 1.16010977492305 -1.16010977492305 -1 8.50683332088154 244 212 864 352 372 189 159 415 102 528 163 191 M18892 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. 24/49 Gene Ontology MF GO:0001105 1.00289688304712e-05 3.3280641370573e-05 255 303.272727272727 246 9.11728595367531e-07 159 1.83149563239221 1.60352964183895 1 16.0995740273037 173 495 191 397 253 205 226 737 254 159 246 192 M18118 GO_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_LIPASE_ACTIVITY.html Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. 2/30 Gene Ontology MF GO:0004806 0.000554016168281018 0.00100136517646078 260 297.5 246.5 6.15725145509178e-05 62 3.59212581005326 -3.59212581005326 -1 21.1509566279062 257 366 666 NA 578 179 119 149 62 363 236 193 M18302 GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. 15/37 Gene Ontology MF GO:0015175 3.91035766080187e-06 1.65024268254024e-05 370 275.818181818182 247 3.55487691929719e-07 105 1.80943434679083 1.94197399741244 1 16.9877736756721 370 310 122 160 197 514 429 395 185 105 247 194 M18360 GO_RECEPTOR_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. 18/40 Gene Ontology MF GO:0030546 3.14721560454901e-05 8.3202251614514e-05 465 273.818181818182 248 2.86114602547613e-06 45 1.79736472398008 1.46409313814947 1 14.3954417851094 465 81 165 59 322 500 248 429 45 189 509 195 M18548 GO_LIPOPOLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with lipopolysaccharide. 11/32 Gene Ontology MF GO:0001530 0.00480545760143576 0.00755730084328358 145 335.818181818182 250 0.000437816942590998 141 3.50985178910507 3.50985178910507 1 14.6184759746457 141 806 209 309 583 202 166 250 330 511 187 196 M19198 GO_OXIDIZED_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDIZED_NAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. 7/18 Gene Ontology MF GO:0070403 0.000345328481532677 0.000652365919938527 200 321.727272727273 250 3.4538215656428e-05 82 1.2869732599963 -1.2869732599963 -1 8.0480621394335 200 186 913 250 444 82 163 271 319 598 113 197 M18067 GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 27/145 Gene Ontology MF GO:0015103 2.07331892889781e-07 3.598968706766e-06 475 304.727272727273 251 1.88483556753734e-08 17 1.45986236314464 1.21871072313066 1 15.6012293931552 471 62 203 251 17 529 473 482 215 201 448 198 M18217 GO_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 69/193 Gene Ontology MF GO:0016247 3.58089604893815e-07 4.42506727776583e-06 275 224.090909090909 251 3.25536057435779e-08 7 1.55456127058974 1.75430543890481 1 16.3393851311778 273 7 57 44 35 318 442 703 251 47 288 199 M18022 GO_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_ACTIVITY.html The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. 2/12 Gene Ontology MF GO:0009881 8.00227944263756e-09 2.87708271898608e-07 5 244.4 252 8.89142163455359e-10 1 4.91073799188897 4.91073799188897 1 63.0575478381654 306 198 640 NA 438 388 107 2 1 362 2 200 M18779 GO_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBULIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. 151/374 Gene Ontology MF GO:0015631 1.00565416315427e-05 3.3280641370573e-05 95 312.818181818182 254 9.1423523653185e-07 73 1.52345292485258 1.66431827359984 1 13.391756265926 73 540 386 649 254 95 91 166 392 684 111 201 M18304 GO_GLUCOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_BINDING.html Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. 6/16 Gene Ontology MF GO:0005536 0.00887557171844167 0.0132557239950752 165 397.181818181818 255 0.00089112213739256 95 3.13259805698275 3.13259805698275 1 11.5464891264067 165 621 708 643 683 163 95 247 226 563 255 202 M17878 GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. 14/37 Gene Ontology MF GO:0008376 5.06181482652798e-06 1.92691142497084e-05 215 308.818181818182 258 4.6016604299229e-07 119 1.0764447775255 1.08081746286137 1 9.96389595874195 202 440 408 507 217 214 213 119 515 304 258 203 M18100 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS.html Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). 87/208 Gene Ontology MF GO:0016758 1.06527066490057e-06 7.30369229697438e-06 270 233.727272727273 259 9.68428346108931e-08 82 1.62312722868459 1.83660355636006 1 16.3666300147395 225 234 308 267 98 416 276 82 136 270 259 204 M18186 GO_PHOSPHATE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_BINDING.html Interacting selectively and non-covalently with phosphate. 8/18 Gene Ontology MF GO:0042301 4.09816060085174e-06 1.69072096537381e-05 370 309.636363636364 260 4.0981681585855e-07 31 1.4120807759931 -1.5485657670391 -1 13.2280682734772 369 120 682 260 207 414 613 232 337 141 31 205 M18527 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS.html Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). 120/288 Gene Ontology MF GO:0016757 8.39822719365275e-07 6.60214443949097e-06 210 226 261 7.63475490870323e-08 37 1.60621999743791 1.83484711532574 1 16.3344379443202 163 261 285 324 82 337 268 37 206 315 208 206 M18754 GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 4/21 Gene Ontology MF GO:0005248 1.05666273661387e-05 3.47189184887414e-05 105 301.454545454545 261 1.05666776106012e-06 92 1.68342956461273 2.00762106733618 1 14.7372914360298 377 105 809 92 261 630 371 124 105 120 322 207 M18922 GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING.html Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. 9/24 Gene Ontology MF GO:0031683 7.01342756971495e-07 5.76102978940871e-06 265 342.909090909091 261 7.0134297831834e-08 49 1.55614341719405 1.24195085201558 1 16.005986798115 261 194 850 262 78 99 49 885 655 290 149 208 M18455 GO_CO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CO_SMAD_BINDING.html Interacting selectively and non-covalently with a common mediator SMAD signaling protein. 8/19 Gene Ontology MF GO:0070410 2.23861630017371e-06 1.15956472029929e-05 770 430.818181818182 262 2.23861855530824e-07 53 1.70971450513275 -2.16474397347112 -1 16.5659288329488 770 185 744 71 162 804 585 221 53 262 882 209 M18706 GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a substance from one side of a membrane to the other. 347/1090 Gene Ontology MF GO:0022857 1.98942695097667e-09 8.71558473761209e-08 95 371.363636363636 262 1.80856995706881e-10 18 1.65556583791144 -1.49247215316402 -1 22.9443583285271 847 92 20 94 104 453 902 422 262 18 871 210 M19119 GO_CADHERIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CADHERIN_BINDING.html Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. 11/34 Gene Ontology MF GO:0045296 1.45850913536917e-05 4.53320406939067e-05 225 291.909090909091 263 1.32592618615645e-06 132 2.1237372912404 2.00902469341549 1 18.1089425355297 324 224 147 224 274 445 230 458 263 132 490 211 M18047 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS.html Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). 32/68 Gene Ontology MF GO:0016765 1.67602735416586e-05 5.06582600172436e-05 110 290.818181818182 264 1.52367283890141e-06 67 1.18775183165627 -1.21853068477098 -1 10.0153755141353 109 264 422 601 280 79 178 164 397 638 67 212 M19200 GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a calcium channel. 18/62 Gene Ontology MF GO:0005246 8.63921512705315e-06 2.98799921687553e-05 265 244.727272727273 264 7.85386277519226e-07 82 1.44439217260346 -0.842884685427495 -1 12.8295135633774 264 82 190 188 244 312 270 230 367 281 264 213 M19009 GO_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. 52/156 Gene Ontology MF GO:0015293 1.30142433346636e-05 4.14294251484102e-05 190 413.272727272727 265 1.18312002926414e-06 125 1.74737790839275 1.70477690829429 1 15.0338669177795 519 188 125 189 265 841 645 717 225 168 664 214 M18823 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. 9/20 Gene Ontology MF GO:0016641 4.63196343782835e-07 4.87603297698976e-06 575 407.090909090909 266 4.63196440330747e-08 55 2.06936196834989 2.64546353063887 1 21.5790381144468 573 67 825 176 55 778 890 266 150 72 626 215 M18889 GO_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BINDING.html Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 146/308 Gene Ontology MF GO:0048037 1.01440661550537e-06 7.11845079997341e-06 210 282.181818181818 267 9.22188257493076e-08 83 1.46930369930394 -1.3653937370042 -1 14.8477480066402 206 255 267 462 95 83 404 419 414 400 99 216 M18368 GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a protein serine/threonine kinase. 19/35 Gene Ontology MF GO:0030291 5.56531459678123e-06 2.08983242001581e-05 210 448.090909090909 268 5.05938970485742e-07 205 1.49861826203438 1.24223553722927 1 13.7679579019708 669 205 208 222 221 802 568 774 268 210 782 217 M18681 GO_GLUTATHIONE_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_TRANSFERASE_ACTIVITY.html Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. 16/38 Gene Ontology MF GO:0004364 0.00018322313497808 0.000375071112184237 195 287.909090909091 268 1.66580360158561e-05 93 1.33483197229365 -1.41064341759106 -1 8.97723417468012 127 191 268 482 406 93 209 380 320 498 193 218 M18373 GO_AMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BINDING.html Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. 4/11 Gene Ontology MF GO:0043176 0.000119480007043181 0.000255631642976108 220 302 270 1.19486431491766e-05 51 3.21631561836947 3.21631561836947 1 22.682168976583 216 270 726 223 395 299 389 205 51 256 292 219 M18782 GO_NADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_BINDING.html Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. 25/65 Gene Ontology MF GO:0050661 1.35572041403537e-05 4.27144787983748e-05 150 272.090909090909 270 1.2324806986838e-06 149 1.67483102444319 -1.59052903808205 -1 14.3660798068876 149 501 217 270 270 180 305 218 405 328 150 220 M18125 GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. 11/36 Gene Ontology MF GO:0005227 1.43310811077573e-05 4.49711936433271e-05 605 359.363636363636 271 1.3028340421002e-06 60 2.09394387575489 -1.76086531879907 -1 17.8691637892733 605 101 119 77 271 835 728 741 60 96 320 221 M18212 GO_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_ACTIVITY.html Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 7/14 Gene Ontology MF GO:0004707 0.000152304719052914 0.000319909455544933 145 323.636363636364 271 1.52315158587272e-05 75 1.3048519838187 -1.3048519838187 -1 8.95257696565744 142 292 689 271 571 108 180 112 734 386 75 222 M18393 GO_SH2_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH2_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. 21/52 Gene Ontology MF GO:0042169 5.1355981856065e-05 0.000123361627434934 310 269.636363636364 271 4.66883461183524e-06 155 1.42680327092047 1.50740539016491 1 10.9484529552334 271 322 309 155 351 336 233 177 307 248 257 223 M18822 GO_GTPASE_ACTIVATING_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVATING_PROTEIN_BINDING.html Interacting selectively and non-covalently with a GTPase activating protein. 13/36 Gene Ontology MF GO:0032794 3.65549035989351e-07 4.42506727776583e-06 210 319.818181818182 271 3.32317360662274e-08 10 1.64944171423581 1.82032232308096 1 17.336636348366 209 592 271 385 525 250 297 10 84 682 213 224 M17892 GO_PROTEIN_COMPLEX_SCAFFOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SCAFFOLD.html Functions to provide a physical support for the assembly of a multiprotein complex. 34/90 Gene Ontology MF GO:0032947 3.85118343174291e-06 1.64031886907568e-05 895 448.363636363636 273 3.50108197582007e-07 133 1.50215151008843 -1.33408844096283 -1 14.110590534068 894 177 273 145 195 832 630 675 133 235 743 225 M18278 GO_PEPTIDASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 25/51 Gene Ontology MF GO:0016504 1.44201110051973e-05 4.49711936433271e-05 305 258.272727272727 273 1.31092777491502e-06 75 1.41598996989409 -1.35301170497989 -1 12.0836842494552 303 162 340 108 273 128 75 502 214 442 294 226 M18897 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 67/180 Gene Ontology MF GO:0016614 6.13234270127244e-07 5.37310027159109e-06 260 286.636363636364 273 5.57485855510889e-08 70 1.4109247131036 -1.49765757477793 -1 14.5961701469016 260 464 339 562 70 86 321 176 444 273 158 227 M18407 GO_FIBROBLAST_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with a fibroblast growth factor. 14/55 Gene Ontology MF GO:0017134 0.00010589066253904 0.000231549767349191 260 366.727272727273 274 9.62688723859236e-06 100 1.41090620054866 1.72819665038036 1 10.0690395123622 181 740 369 256 724 256 274 100 519 445 170 228 M18817 GO_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_A2_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. 7/33 Gene Ontology MF GO:0004623 1.13663721756458e-05 3.66914470231374e-05 275 360.181818181818 274 1.13664303135517e-06 92 1.38606998537311 1.65148006051068 1 12.0688084093156 274 228 824 299 264 237 181 869 303 391 92 229 M18209 GO_GLUTATHIONE_PEROXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_PEROXIDASE_ACTIVITY.html Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. 11/17 Gene Ontology MF GO:0004602 0.000609271404407958 0.00108840716903946 150 278.909090909091 276 5.54036547657454e-05 60 1.288052121653 -1.11419704211139 -1 7.49270545568007 148 183 276 433 468 70 60 407 500 350 173 230 M18848 GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). 21/28 Gene Ontology MF GO:0015295 1.55116893169296e-05 4.74774169856093e-05 885 459.363636363636 276 1.41016351702999e-06 211 1.62537804012355 -1.3413215578003 -1 13.7953952534424 882 219 261 253 276 769 788 211 240 347 807 231 M18129 GO_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. 12/41 Gene Ontology MF GO:0004180 4.00799175066277e-06 1.67606927754989e-05 60 247.454545454545 277 3.64363550227146e-07 26 1.85716465480653 1.85716465480653 1 17.4112991652244 56 312 277 534 506 37 43 26 328 541 62 232 M18245 GO_SCAVENGER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAVENGER_RECEPTOR_ACTIVITY.html Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). 18/49 Gene Ontology MF GO:0005044 1.28604367544571e-07 2.81704805097631e-06 135 308.272727272727 277 1.16913068238488e-08 29 2.22894229378078 1.81836790629238 1 24.2857157886232 132 80 29 234 311 479 541 776 277 41 491 233 M18829 GO_ENZYME_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_REGULATOR_ACTIVITY.html Binds to and modulates the activity of an enzyme. 456/1178 Gene Ontology MF GO:0030234 1.97790543207541e-07 3.4993711490565e-06 405 298.090909090909 280 1.79809600899874e-08 3 1.52180318461672 1.67836917882953 1 16.2995886937898 405 3 86 158 15 862 502 359 280 52 557 234 M17881 GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. 62/204 Gene Ontology MF GO:0022853 6.08765860712978e-07 5.37310027159109e-06 120 426.363636363636 281 5.5342366287792e-08 69 1.57214594845948 1.51534869575787 1 16.2640214335243 697 202 116 118 69 743 802 755 281 82 825 235 M18135 GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. 18/45 Gene Ontology MF GO:0015662 1.70385590923056e-05 5.08080375535743e-05 445 298.363636363636 282 1.54897191399653e-06 72 1.50024281109876 1.39917316488656 1 12.6465896913852 444 181 134 72 282 441 348 568 267 101 444 236 M18684 GO_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. 19/59 Gene Ontology MF GO:0008146 0.000736090726469749 0.00129732465201565 480 364.636363636364 282 6.69397389145263e-05 138 1.66726583449562 1.60933570098781 1 9.4490318070803 282 237 138 279 477 447 266 839 358 211 477 237 M17861 GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. 16/32 Gene Ontology MF GO:0035250 0.000292329253479857 0.000560297735836392 285 298.909090909091 284 2.6578918592924e-05 121 2.22476655749139 2.25753268187267 1 14.2011018412861 284 424 166 392 434 449 310 202 121 239 267 238 M18026 GO_PROTEIN_LIPID_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_BINDING.html Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. 8/37 Gene Ontology MF GO:0071814 0.0144907333267908 0.0209614381456722 285 352.818181818182 284 0.00145861013434772 47 1.79080567242697 1.79080567242697 1 5.90110337358716 47 364 643 281 640 279 284 308 654 140 241 239 M19172 GO_MACROMOLECULAR_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_BINDING.html Interacting selectively and non-covalently with any macromolecular complex. 776/1921 Gene Ontology MF GO:0044877 4.2710419875273e-06 1.7309949905397e-05 285 390.818181818182 284 4.27105019635935e-07 168 1.72463492799122 1.94527921604952 1 16.1213939002205 168 607 905 561 208 432 283 235 350 266 284 240 M19156 GO_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. 469/1395 Gene Ontology MF GO:0005215 9.31911020951712e-07 7.02752573176701e-06 830 361.181818181818 285 8.47192196096047e-08 35 1.60136757780373 -1.47273458390627 -1 16.1998436551637 827 199 40 265 87 285 840 426 336 35 633 241 M19184 GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. 39/108 Gene Ontology MF GO:0000980 2.11977999133867e-05 6.00060797548178e-05 285 306.727272727273 285 1.9270912876956e-06 120 2.38495632185718 2.4461288081133 1 19.7661266482309 285 580 120 429 299 268 132 253 199 397 412 242 M19188 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING.html Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. 26/57 Gene Ontology MF GO:0032813 1.91581122897288e-05 5.5776782615666e-05 185 274.818181818182 286 1.74166173864234e-06 173 1.46808391986913 -1.35249590544736 -1 12.2587184289271 445 352 286 252 291 182 325 307 182 173 228 243 M18237 GO_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_ACTIVITY.html The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. 25/137 Gene Ontology MF GO:0005179 1.06078083850769e-05 3.47301911539883e-05 175 284.909090909091 287 9.64350866674688e-07 98 2.6033123263634 2.5368920678093 1 22.7895246763348 172 443 98 371 257 287 174 423 315 325 269 244 M18179 GO_METALLOCARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOCARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 6/28 Gene Ontology MF GO:0004181 9.78804122479498e-05 0.000219099706248452 185 345.818181818182 288 9.78847237740234e-06 101 2.99762185843672 2.99762185843672 1 21.5340030808573 182 348 681 418 592 288 222 101 198 560 214 245 M18581 GO_IDENTICAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IDENTICAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with an identical protein or proteins. 696/1724 Gene Ontology MF GO:0042802 6.69167221073544e-07 5.66789036269149e-06 335 314.818181818182 288 6.69167422576774e-08 60 1.69924059603719 1.93029084271444 1 17.5014509519115 331 74 773 127 77 654 449 288 269 60 361 246 M18121 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 118/368 Gene Ontology MF GO:0001228 2.20677809119001e-06 1.15725170177853e-05 485 393.090909090909 289 2.00616391342744e-07 80 1.68112578146307 1.69613618335394 1 16.2917860822276 485 233 80 132 152 755 447 848 289 158 745 247 M18414 GO_STEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 6/25 Gene Ontology MF GO:0015248 1.71387994265906e-05 5.086353378214e-05 290 275.818181818182 289 1.71389316103261e-06 14 3.48054419720966 3.48054419720966 1 29.336687568313 289 170 735 14 290 555 497 77 27 339 41 248 M18253 GO_CAMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BINDING.html Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). 6/29 Gene Ontology MF GO:0030552 0.0001551777156882 0.000324462496438963 100 305.727272727273 290 1.55188552808829e-05 51 1.27112750962992 1.27112750962992 1 8.70587861311493 100 408 699 290 402 84 51 228 433 562 106 249 M18628 GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 32/82 Gene Ontology MF GO:0005089 2.57028243324604e-06 1.23159366593039e-05 500 398.636363636364 290 2.33662312376193e-07 78 1.22187825159103 -1.39269574652487 -1 11.7763601133789 497 78 290 151 166 572 873 807 235 206 510 250 M18418 GO_BINDING_BRIDGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_BRIDGING.html The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. 86/250 Gene Ontology MF GO:0060090 9.64935446572965e-07 7.11845079997341e-06 475 344.636363636364 291 8.77214427091534e-08 89 1.44201671377699 1.59953977780224 1 14.5720049538014 473 127 245 185 89 643 579 291 222 309 628 251 M18247 GO_ICOSANOID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_RECEPTOR_ACTIVITY.html Combining with an icosanoid to initiate a change in cell activity. 4/14 Gene Ontology MF GO:0004953 0.0275316382491207 0.0383193754753268 700 401.181818181818 292 0.00278788031608229 125 2.94879343248783 2.94879343248783 1 8.20028482942705 125 437 696 292 656 253 218 292 697 477 270 252 M19094 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 9/18 Gene Ontology MF GO:0004675 2.37853226603857e-06 1.17647832513736e-05 140 293.909090909091 292 2.37853481187948e-07 22 1.54945631776883 1.73912632992646 1 14.9940105897772 139 416 891 316 428 143 125 22 343 292 118 253 M19153 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the platelet-derived growth factor receptor. 9/18 Gene Ontology MF GO:0005161 4.66625790847112e-05 0.000113871545777014 660 390.454545454545 293 4.66635589419981e-06 78 1.59659069051969 1.59659069051969 1 12.3602647689251 119 657 901 598 632 131 79 78 656 293 151 254 M17863 GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate from one side of the membrane to the other. 15/38 Gene Ontology MF GO:1901677 7.77216226585245e-06 2.72915621549017e-05 440 285.181818181818 296 7.06562702135555e-07 83 0.948318180596753 -0.67529576188881 -1 8.49649894603785 440 83 390 124 238 392 254 178 296 324 418 255 M19175 GO_ACID_THIOL_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_THIOL_LIGASE_ACTIVITY.html Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 8/20 Gene Ontology MF GO:0016878 0.00383693074918662 0.00609684041306312 300 398.545454545455 296 0.000384357180993298 110 1.13157935285108 -1.13157935285108 -1 4.92018219505086 296 283 907 564 600 135 110 207 437 614 231 256 M18475 GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES.html Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance. 52/130 Gene Ontology MF GO:0043492 3.97644275564461e-06 1.67046910282787e-05 300 368.909090909091 300 3.61495449361782e-07 198 1.5183920401222 -1.40419849021348 -1 14.2395690597613 613 350 226 275 198 327 667 300 297 212 593 257 M19229 GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY.html Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. 7/21 Gene Ontology MF GO:0030296 0.00106219367078217 0.00183687627278119 155 381.636363636364 300 0.000106270172752416 42 2.43891561039836 2.43891561039836 1 13.0991520104361 151 742 920 217 618 314 300 167 42 599 128 258 M18091 GO_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. 283/710 Gene Ontology MF GO:0004672 1.62165757983804e-07 3.1081770280229e-06 250 275.545454545455 302 1.47423427215745e-08 12 1.33577253614805 1.49699493713028 1 14.4420738743474 246 172 317 377 12 365 351 302 434 218 237 259 M18361 GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. 4/19 Gene Ontology MF GO:0015114 5.98984013665651e-06 2.22203747005e-05 190 327.636363636364 304 5.98985628190096e-07 29 1.17093909090952 1.17093909090952 1 10.6962996445746 189 484 722 304 358 198 224 29 436 479 181 260 M18649 GO_CARGO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARGO_RECEPTOR_ACTIVITY.html Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis. 31/78 Gene Ontology MF GO:0038024 2.95098305678236e-08 8.75775616851538e-07 30 370.363636363636 304 2.68271190578686e-09 27 2.01951007189692 1.61557798069335 1 24.0154168321826 304 116 27 205 225 745 815 662 308 29 638 261 M18815 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. 20/49 Gene Ontology MF GO:0016684 4.70606303030753e-06 1.85024700336877e-05 255 391.545454545455 304 4.27824827015378e-07 164 1.10924074981661 -0.995713997791606 -1 10.3058600388971 251 164 304 551 210 190 170 768 728 578 393 262 M18297 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. 43/95 Gene Ontology MF GO:0004722 2.19123382315314e-05 6.18385005307021e-05 305 378 305 1.99205058953022e-06 127 2.03487785279086 2.594871892956 1 16.8125485222719 305 683 464 712 301 377 135 140 127 705 209 263 M19005 GO_P53_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_P53_BINDING.html Interacting selectively and non-covalently with one of the p53 family of proteins. 49/92 Gene Ontology MF GO:0002039 0.000300730676264863 0.000574008759675672 205 398 305 2.73428902493305e-05 205 2.15877429095824 2.21624413299839 1 13.7353644048834 205 788 254 637 436 390 259 278 223 603 305 264 M19126 GO_OPSONIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPSONIN_BINDING.html Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. 5/21 Gene Ontology MF GO:0001846 0.000268518016644677 0.000521174209521314 145 310.909090909091 305 2.68550468029909e-05 38 1.41584824292716 1.41584824292716 1 9.12499944296868 145 305 900 330 454 117 38 129 313 529 160 265 M18109 GO_LIGAND_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 39/161 Gene Ontology MF GO:0022834 5.85372624285301e-07 5.27983151316154e-06 840 426.545454545455 306 5.32157072764007e-08 68 1.62442562245561 -1.56875489474862 -1 16.8291116851314 839 130 102 107 68 913 741 688 306 71 727 266 M17854 GO_COFACTOR_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORTER_ACTIVITY.html Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. 11/23 Gene Ontology MF GO:0051184 0.000604369728025195 0.00108175126416961 550 306.454545454545 307 5.49578018580588e-05 107 1.69047084167759 -1.98216008198114 -1 9.84244898530583 549 313 307 410 467 260 211 194 107 229 324 267 M18776 GO_NEUREXIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUREXIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. 9/14 Gene Ontology MF GO:0042043 0.000164746930568093 0.000343298640607769 390 364.636363636364 308 1.64759145540629e-05 206 1.90992208662603 -2.08642665421633 -1 12.9890576280723 389 302 816 383 405 308 412 265 236 289 206 268 M18862 GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. 10/43 Gene Ontology MF GO:0005310 3.25952393142261e-05 8.54348152965471e-05 415 272.272727272727 308 2.96324747780833e-06 67 2.23774671595988 1.97726398658541 1 17.8720285771009 411 225 112 133 324 468 308 369 67 86 492 269 M18411 GO_CATION_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 30/70 Gene Ontology MF GO:0019829 8.12075252717483e-06 2.81928012264183e-05 420 314.545454545455 309 7.38252954824257e-07 227 1.38660819791847 -1.4727252493598 -1 12.3849701746297 418 405 297 239 241 247 423 227 309 323 331 270 M18967 GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a sodium channel. 18/43 Gene Ontology MF GO:0017080 2.3968510053603e-06 1.17919942509705e-05 610 361.818181818182 309 2.17895783334552e-07 146 1.74164542770805 -1.75045044017787 -1 16.8503845106137 606 309 146 213 160 562 748 234 453 190 359 271 M17886 GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 8/19 Gene Ontology MF GO:0070008 5.95697431579392e-05 0.000140523496680267 105 271.909090909091 310 5.95713400676219e-06 34 1.53967398747382 1.78691315736964 1 11.6435752353027 101 315 614 380 585 66 34 88 310 415 83 272 M18939 GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. 6/28 Gene Ontology MF GO:0030898 0.00538161922016234 0.00832115913033504 165 405.909090909091 310 0.000539469663618354 56 3.31515902387072 3.31515902387072 1 13.5354380664557 161 583 858 401 917 187 207 215 56 570 310 273 M18537 GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. 125/394 Gene Ontology MF GO:0022804 1.4868525624135e-06 8.88249582740531e-06 630 420.727272727273 311 1.35168506117452e-07 76 1.61071939566651 1.65845961857893 1 15.9727698968855 630 243 84 235 127 786 743 655 311 76 738 274 M18661 GO_MAP_KINASE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. 10/14 Gene Ontology MF GO:0033549 4.2945145906564e-06 1.73287430851048e-05 195 395.181818181818 311 3.90411179435952e-07 193 1.1705174699646 -1.42933940369825 -1 10.9405795367127 689 193 280 311 204 597 632 310 507 193 431 275 M18016 GO_ENHANCER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENHANCER_BINDING.html Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. 56/142 Gene Ontology MF GO:0035326 0.000121367827973878 0.000259068217484843 315 332.909090909091 312 1.1034047637602e-05 132 1.91284669887346 2.14436719806662 1 13.4680399942061 312 594 132 451 391 267 165 236 295 470 349 276 M18162 GO_SEROTONIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_ACTIVITY.html Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. 2/14 Gene Ontology MF GO:0099589 0.00303244651687902 0.00492906500976802 280 369 312.5 0.000337393481035917 70 3.36354643817181 3.36354643817181 1 15.2346451976897 280 551 679 NA 635 293 282 204 70 364 332 277 M18449 GO_ATPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_BINDING.html Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. 45/113 Gene Ontology MF GO:0051117 0.00018378770670469 0.000375071112184237 420 306.454545454545 314 1.67093692819217e-05 114 1.30941391038778 -1.43576056511392 -1 8.80628839185488 420 272 306 337 478 126 335 114 475 314 194 278 M18962 GO_MAP_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_ACTIVITY.html Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. 9/17 Gene Ontology MF GO:0004708 0.000144898311708486 0.000305049077281023 365 360.454545454545 314 1.4490776055994e-05 125 1.62370923473275 1.35303992713175 1 11.2060990347585 364 314 862 209 398 281 182 581 125 291 358 279 M18363 GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. 10/70 Gene Ontology MF GO:0030594 4.31988963039656e-05 0.000106549556567422 190 326.181818181818 315 3.92724950680448e-06 73 2.19083770560705 -2.19083770560705 -1 17.0848616482542 233 538 315 502 581 154 190 73 324 490 188 280 M18549 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING.html Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. 8/27 Gene Ontology MF GO:0016922 0.000211896413656692 0.000424716123233456 190 336 315 2.119166214092e-05 93 0.875200906938905 -1.03241637804762 -1 5.79329443978071 187 389 767 335 418 122 168 315 293 609 93 281 M18291 GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS.html Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 18/40 Gene Ontology MF GO:0016877 0.000511166553881578 0.000934936838113424 275 375.090909090909 317 4.64804873889151e-05 243 1.10721885622491 -1.23693156133985 -1 6.58425980466861 386 274 471 541 455 248 243 275 317 642 274 282 M18521 GO_PALMITOYL_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYL_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. 8/16 Gene Ontology MF GO:0016290 9.17403732861572e-07 6.97530110936072e-06 430 293.181818181818 317 9.17404111595117e-08 14 1.8066651498472 -0.946827377422317 -1 18.2881757508574 428 141 761 87 93 274 333 317 14 424 353 283 M19151 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS.html Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. 65/156 Gene Ontology MF GO:0016810 6.88971933775858e-06 2.44731343271733e-05 230 357.727272727273 317 6.26340083120228e-07 191 1.60721325180824 -1.47351372135028 -1 14.5492585426556 454 359 229 375 236 227 652 653 191 242 317 284 M18584 GO_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 18/36 Gene Ontology MF GO:0008378 0.00024513055908148 0.000480853122292029 335 321.727272727273 318 2.22870796836915e-05 144 2.00267756915018 2.25753268187267 1 13.0445405181559 335 413 180 405 424 466 293 281 144 280 318 285 M19035 GO_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glutamate receptor. 21/50 Gene Ontology MF GO:0035254 3.8403002211487e-05 9.78282786533885e-05 340 305.272727272727 318 3.4912429624749e-06 68 1.54846633971678 -1.62624049142653 -1 12.1881794737554 340 475 264 254 344 269 593 68 318 348 85 286 M19143 GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. 12/30 Gene Ontology MF GO:0070001 0.000536397522436883 0.000975268222612515 75 331.363636363636 318 4.87753045418924e-05 47 1.20444903367369 -1.20444903367369 -1 7.11908672025893 74 543 318 657 461 69 47 217 540 550 169 287 M19004 GO_RIBONUCLEASE_P_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_P_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. 6/11 Gene Ontology MF GO:0004526 2.58133305987468e-05 7.04696265603769e-05 280 456.181818181818 319 2.58136304512653e-06 252 0.817827137870305 -0.817827137870305 -1 6.66594387113398 288 522 868 536 319 252 307 279 482 889 276 288 M19214 GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. 10/25 Gene Ontology MF GO:0070273 7.23125692200769e-06 2.5587524493258e-05 410 286.909090909091 319 6.57389153708025e-07 49 1.19163294620678 1.47453214998047 1 10.7419890692521 410 103 319 249 237 421 175 49 331 495 367 289 M18269 GO_L_ASCORBIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_BINDING.html Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 13/21 Gene Ontology MF GO:0031418 0.00828694470371793 0.0124574985742165 310 391.090909090909 321 0.000756211411063135 88 1.47099080113448 1.91224268375373 1 5.49983547420801 300 489 303 308 847 321 88 572 360 408 306 290 M18878 GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. 73/254 Gene Ontology MF GO:0015291 9.63096745970155e-06 3.23375549741804e-05 325 336.181818181818 321 8.7554632923331e-07 92 1.61923530637927 1.5813159720429 1 14.2734062627096 321 173 108 207 250 567 384 742 352 92 502 291 M19052 GO_GAP_JUNCTION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION_CHANNEL_ACTIVITY.html A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. 9/19 Gene Ontology MF GO:0005243 0.000183866382168577 0.000375071112184237 210 362.454545454545 321 1.83881597021278e-05 110 2.25636663598744 2.09660133364355 1 15.1748925590645 208 278 879 258 415 404 229 517 321 110 368 292 M19040 GO_ARYLSULFATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYLSULFATASE_ACTIVITY.html Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. 4/10 Gene Ontology MF GO:0004065 0.000356835806116531 0.000667253946396765 215 375.909090909091 324 3.56893118375934e-05 16 3.40014050976233 3.40014050976233 1 21.1972998906166 212 659 875 232 721 373 324 137 16 486 100 293 M18805 GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. 21/74 Gene Ontology MF GO:0008028 3.279543844698e-05 8.57153504864249e-05 60 332.727272727273 325 2.98144793994156e-06 56 2.01261365949115 1.85307168463192 1 16.068351735742 372 204 56 144 325 553 511 650 250 58 537 294 M18266 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a protein serine/threonine kinase. 15/25 Gene Ontology MF GO:0043539 3.35075892211934e-05 8.73285611430535e-05 335 302.454545454545 326 3.04619087062405e-06 114 1.30540135038945 -1.36570538894797 -1 10.4013421606668 380 362 334 194 326 223 604 241 335 214 114 295 M18371 GO_TRANSCRIPTION_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COFACTOR_BINDING.html Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. 12/34 Gene Ontology MF GO:0001221 0.0136815792935334 0.0199162230222321 330 418.090909090909 326 0.00125158289972156 213 1.72839984574344 -1.72839984574344 -1 5.77083528587507 326 656 489 499 729 213 292 254 282 544 315 296 M18708 GO_PEPTIDE_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_BINDING.html Interacting selectively and non-covalently with any peptide with hormonal activity in animals. 11/55 Gene Ontology MF GO:0017046 1.72648036237664e-05 5.09090363264905e-05 330 334.363636363636 326 1.56953991938037e-06 156 2.21941481431491 1.9040223990399 1 18.705232887592 218 415 156 327 286 304 286 645 326 353 362 297 M18701 GO_QUATERNARY_AMMONIUM_GROUP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_BINDING.html Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 10/56 Gene Ontology MF GO:0050997 3.74743079697456e-05 9.65724463085881e-05 330 358 329 3.40681330126812e-06 237 1.59769744605722 -1.7524727432769 -1 12.5932830518852 329 497 237 448 329 284 320 311 512 321 350 298 M19031 GO_DEATH_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_ACTIVITY.html Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. 12/23 Gene Ontology MF GO:0005035 0.000905801976545767 0.00158731013032782 240 368.454545454545 329 8.23795578046363e-05 124 1.67847720654455 1.67847720654455 1 9.22388369564658 240 572 313 540 607 329 124 155 426 549 198 299 M18445 GO_PYRIDOXAL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDOXAL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. 25/53 Gene Ontology MF GO:0030170 3.78797173598196e-05 9.7320403856916e-05 330 422.727272727273 330 3.44366996277601e-06 16 1.28621705276162 -1.12507382221885 -1 10.1296890251469 696 16 207 169 330 794 825 301 383 326 603 300 M19201 GO_THIOESTERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTERASE_BINDING.html Interacting selectively and non-covalently with any thioesterase enzyme. 6/16 Gene Ontology MF GO:0031996 1.77911870060931e-05 5.22935848102417e-05 440 360.454545454545 330 1.77913294445489e-06 154 1.62524826226039 -1.42402474801223 -1 13.6604149142924 437 209 914 154 294 344 454 330 245 183 401 301 M17973 GO_PROTEIN_HETERODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETERODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. 238/584 Gene Ontology MF GO:0046982 9.85369512572114e-06 3.29650891478671e-05 425 326 331 8.95794478202603e-07 91 1.70570135804461 2.14917088874949 1 15.0076464432393 263 535 91 472 251 423 424 331 357 238 201 302 M18671 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. 9/29 Gene Ontology MF GO:0016701 1.94611176564257e-05 5.61261073476854e-05 490 355.272727272727 332 1.94612880893216e-06 109 2.55750580534379 -3.13713163217475 -1 21.3419394925149 488 139 795 332 300 436 649 116 171 109 373 303 M18932 GO_NUCLEOSOMAL_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOMAL_DNA_BINDING.html Interacting selectively and non-covalently with the DNA portion of a nucleosome. 24/61 Gene Ontology MF GO:0031492 3.80818971614019e-05 9.7320403856916e-05 310 366.909090909091 332 3.46205057938518e-06 122 2.05452609293765 2.26998274216429 1 16.1805586738493 308 474 246 514 332 458 304 238 122 621 419 304 M18473 GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. 9/55 Gene Ontology MF GO:0005231 7.06765809773675e-05 0.000164198117422167 215 344 333 7.0678828908584e-06 169 2.09825025633294 2.14461133695493 1 15.5892033351671 214 516 748 396 367 277 204 383 177 169 333 305 M17869 GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. 9/21 Gene Ontology MF GO:0034237 0.00048455199618992 0.000889796080827797 145 345.363636363636 334 4.84657684411927e-05 61 1.58824453435465 1.58824453435465 1 9.51176744370156 144 714 611 248 460 334 385 156 61 453 233 306 M18477 GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 21/44 Gene Ontology MF GO:0046915 9.55902601064267e-06 3.22135675083929e-05 425 324.272727272727 335 8.69006140452396e-07 134 1.59259122721284 -1.39686237309079 -1 14.043757202998 423 134 335 366 249 280 468 328 287 345 352 307 M18106 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a lipoprotein particle receptor. 11/30 Gene Ontology MF GO:0070325 0.000130813131927528 0.000277299726666649 135 364.818181818182 337 1.18928100719286e-05 107 1.62446471066046 1.62446471066046 1 11.3434018629143 135 670 337 404 859 171 238 107 348 510 234 308 M17849 GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. 7/25 Gene Ontology MF GO:0004112 7.49610507993969e-05 0.000172842523146479 195 316.818181818182 338 7.49635795410622e-06 54 1.12140761561621 1.12140761561621 1 8.28257970078865 194 338 608 465 495 142 54 95 600 384 110 309 M19109 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS.html Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). 29/59 Gene Ontology MF GO:0016763 1.51367626466372e-07 3.1081770280229e-06 270 323.090909090909 338 1.37606942619082e-08 9 1.4985116953876 1.75462345698921 1 16.2015732741777 270 465 360 425 9 338 327 196 378 503 283 310 M17921 GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a sulfur compound from one side of the membrane to the other. 6/29 Gene Ontology MF GO:1901682 3.59500834100669e-05 9.34295953029987e-05 825 451.454545454545 339 3.59506650071327e-06 90 1.47283438539672 -1.29235369095599 -1 11.6506390564175 822 90 619 211 339 836 658 257 159 175 800 311 M17855 GO_BETA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_BINDING.html Interacting selectively and non-covalently with the beta subunit of the catenin complex. 43/129 Gene Ontology MF GO:0008013 4.63751718579678e-05 0.000113471165184389 325 349.727272727273 340 4.21601358708947e-06 178 2.12014363786009 2.99018814165863 1 16.4198012346818 323 640 178 368 346 539 208 340 258 360 287 312 M18050 GO_ATPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the ATP hydrolysis activity of an ATPase. 12/24 Gene Ontology MF GO:0001671 2.26966946662836e-05 6.38561440152321e-05 575 398.909090909091 340 2.06335716583525e-06 171 1.27270379661219 0.789825544889884 1 10.4804835072959 572 288 398 329 303 582 340 171 205 540 660 313 M18819 GO_TITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TITIN_BINDING.html Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. 14/28 Gene Ontology MF GO:0031432 0.0132466078845591 0.0193135962817661 365 383.545454545455 340 0.00121154973307203 219 1.57216991182692 -1.39703925928365 -1 5.29039338384341 362 287 298 219 576 340 294 476 561 308 498 314 M18412 GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. 32/83 Gene Ontology MF GO:0042625 2.3342960183571e-05 6.48807352534299e-05 650 381.454545454545 341 2.12210980602234e-06 182 1.37009945134745 -1.4727252493598 -1 11.2639252398467 646 371 260 182 308 422 684 293 341 205 484 315 M18052 GO_VIRUS_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRUS_RECEPTOR_ACTIVITY.html Combining with a virus component and mediating entry of the virus into the cell. 44/110 Gene Ontology MF GO:0001618 1.44699116187493e-06 8.806088038901e-06 170 348.272727272727 343 1.31544737599594e-07 106 1.81543553969428 1.70807636151954 1 18.0162182390055 166 575 106 284 124 545 425 749 380 134 343 316 M18176 GO_INSULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin receptor. 17/46 Gene Ontology MF GO:0005158 3.65358181766964e-05 9.4684373866368e-05 155 353.909090909091 343 3.32149317709828e-06 65 1.94573444114928 1.94573444114928 1 15.3693145827672 155 644 314 515 481 363 343 65 302 507 204 317 M18469 GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). 4/12 Gene Ontology MF GO:0008556 4.084648506924e-05 0.0001021162126731 765 372.272727272727 343 4.08472358845674e-06 20 1.8273092380515 -2.28976312783162 -1 14.3161576404052 762 73 747 79 343 887 359 103 20 257 465 318 M18950 GO_ACTIN_MONOMER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MONOMER_BINDING.html Interacting selectively and non-covalently with monomeric actin, also known as G-actin. 18/36 Gene Ontology MF GO:0003785 3.90240586846619e-05 9.83620109312027e-05 205 339.727272727273 343 3.54770462897653e-06 65 1.38868526720741 1.59927038719015 1 10.9240800966514 247 398 343 427 338 203 65 390 480 643 203 319 M18188 GO_FAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 10/15 Gene Ontology MF GO:0071949 2.27825457120523e-06 1.16444122528267e-05 600 416.363636363636 344 2.07114266409212e-07 155 1.37134999056474 -1.00721589645738 -1 13.2825085240967 598 277 329 354 155 602 869 209 344 319 524 320 M18690 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 85/280 Gene Ontology MF GO:0001077 2.63783731996911e-05 7.17991223186859e-05 410 411.454545454545 344 2.39806268056089e-06 176 1.52131589151165 1.55606136259806 1 12.3756968337077 409 358 176 294 313 577 319 731 323 344 682 321 M18226 GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. 32/94 Gene Ontology MF GO:0008081 4.40059150955703e-07 4.87603297698976e-06 345 326 345 4.00053853617627e-08 43 1.54080439924998 1.3265601033248 1 16.0673083375176 345 344 145 376 43 384 212 599 447 147 544 322 M18934 GO_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVITY.html Catalysis of the hydrolysis of a lipid or phospholipid. 38/132 Gene Ontology MF GO:0016298 8.64550089095015e-07 6.63496295130765e-06 905 443 345 7.85954935312521e-08 85 1.89007410905716 -2.14277844489765 -1 19.213099170237 901 286 123 345 85 763 909 437 209 166 649 323 M19003 GO_GLUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 10/16 Gene Ontology MF GO:0046527 4.63174178844118e-05 0.000113471165184389 485 348 345 4.21076300463387e-06 99 1.20344029598951 -0.498588130271636 -1 9.3202413349685 482 168 388 214 345 663 446 206 99 494 323 324 M18733 GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING.html Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. 21/54 Gene Ontology MF GO:0043548 0.000725371997695291 0.00128088721282086 235 350 346 6.59646612591166e-05 218 1.49972863731271 1.63952526286085 1 8.51583845673083 328 282 235 233 476 406 398 441 218 346 487 325 M18966 GO_PROTEIN_DOMAIN_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DOMAIN_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a specific domain of a protein. 375/931 Gene Ontology MF GO:0019904 2.51740100973347e-07 3.7799829111349e-06 365 300.727272727273 347 2.28854663435724e-08 25 1.48719787010985 1.62625701897827 1 15.8311378015652 363 213 143 197 25 543 387 574 347 121 395 326 M19182 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 21/89 Gene Ontology MF GO:0004869 4.7459879204188e-05 0.000115510817110722 515 407.181818181818 348 4.31462755195775e-06 178 2.12664831531764 -1.96751311874343 -1 16.4378765377842 511 300 216 181 348 652 727 734 178 251 381 327 M19081 GO_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 331/838 Gene Ontology MF GO:0016491 1.97928377436704e-06 1.07114180730451e-05 350 388.545454545455 350 1.79935050461846e-07 120 1.43856406973935 -1.28648060432377 -1 14.0359550617642 294 586 350 848 144 120 416 349 473 446 248 328 M17884 GO_NEUROTRANSMITTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BINDING.html Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 5/32 Gene Ontology MF GO:0042165 1.56693746857554e-06 9.24091327621471e-06 430 332.272727272727 351 1.5669385734585e-07 57 1.6514669171765 1.49761686853125 1 16.3211473308104 430 104 613 123 136 538 462 693 57 148 351 329 M18487 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. 33/74 Gene Ontology MF GO:0098811 5.35048203711594e-05 0.000127524442335406 240 379.636363636364 353 4.86419287933184e-06 213 1.78246414450978 1.60352964183895 1 13.6271517021664 238 669 228 547 353 333 330 536 369 213 360 330 M18710 GO_KINESIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_BINDING.html Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. 24/60 Gene Ontology MF GO:0019894 3.0471152273491e-06 1.3674858581274e-05 525 361.545454545455 353 2.77010858888315e-07 155 1.90182872308324 2.4973894889107 1 18.1599587449 524 353 179 501 183 515 341 272 155 411 543 331 M17911 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS.html Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). 24/77 Gene Ontology MF GO:0016782 0.000153787542429795 0.000322288243816428 375 363.636363636364 354 1.39816630689495e-05 149 1.47418960249679 1.45353980338187 1 10.1050896863745 371 149 159 257 397 504 309 718 354 219 563 332 M18180 GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY.html Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. 10/21 Gene Ontology MF GO:0004029 5.39450605080047e-05 0.000128241487512569 710 418.818181818182 354 4.9042166647548e-06 116 1.79193086481003 -1.93578407753223 -1 13.6909598047375 709 226 221 177 354 470 709 669 116 118 838 333 M18574 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 131/414 Gene Ontology MF GO:0000982 1.1309741774582e-05 3.6637191664139e-05 380 394.727272727273 355 1.02816362872976e-06 161 1.55056639387089 1.56710783285914 1 13.503070118382 376 307 161 342 259 580 399 691 355 237 635 334 M18678 GO_CHEMOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_ACTIVITY.html The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 15/62 Gene Ontology MF GO:0008009 0.000125764655698059 0.000267832137134756 220 352.545454545455 355 1.14338041549717e-05 133 1.984549292376 1.9973543504976 1 13.9165964748744 217 386 133 627 392 369 355 252 595 216 336 335 M18781 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. 9/20 Gene Ontology MF GO:0019198 4.91558547205198e-06 1.89219189719156e-05 185 371.636363636364 356 4.91559634542707e-07 71 1.2989181442704 1.57088075249604 1 12.0433117855128 184 383 817 356 220 210 71 435 678 461 273 336 M18935 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION.html Any protein binding that is involved in cell-cell adhesion. 6/15 Gene Ontology MF GO:0098632 5.02468010326676e-05 0.000121330858136625 650 413 356 5.02479372022803e-06 111 1.86895197023226 -3.17784612437004 -1 14.3676920040437 650 196 856 227 356 385 146 111 142 569 905 337 M17889 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. 11/26 Gene Ontology MF GO:0080025 0.000281668385269346 0.000543259778716558 190 391.545454545455 358 2.56094958221236e-05 126 1.18155393319805 1.18155393319805 1 7.57318782611165 190 679 450 399 744 358 246 126 271 659 185 338 M18659 GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). 13/28 Gene Ontology MF GO:0036442 9.81816630821307e-05 0.000219240606882428 70 285.818181818182 358 8.92600409181709e-06 41 1.17690914976213 -1.17690914976213 -1 8.45391200918404 70 591 452 358 380 41 72 122 389 574 95 339 M17950 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of hydrogen ions from one side of a membrane to the other. 42/114 Gene Ontology MF GO:0015078 0.00207852866857785 0.00346421444762975 95 355.272727272727 359 0.000189135912206042 74 1.3383625459911 -1.20890618177742 -1 6.46430213813707 94 587 522 570 510 74 113 259 359 656 164 340 M18357 GO_IMMUNOGLOBULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. 2/121 Gene Ontology MF GO:0034987 8.84191287874994e-06 3.03528352554102e-05 130 416.6 360 9.82438625039306e-07 5 0.754639173726346 0.754639173726346 1 6.69282414188198 230 490 721 NA 906 129 5 110 616 829 130 341 M19038 GO_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. 165/602 Gene Ontology MF GO:0004175 2.72708467955767e-06 1.27356238842287e-05 630 439.818181818182 365 2.47917096364902e-07 128 1.84601546682423 -1.73575452018311 -1 17.7390042268977 626 654 128 839 173 167 606 766 365 187 327 342 M18051 GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. 2/11 Gene Ontology MF GO:0019203 0.0862197256001478 0.103824800460911 300 502.6 365.5 0.00996833200572315 199 0.72888579324872 -0.72888579324872 -1 1.40755262675714 297 349 652 NA 889 300 199 352 815 794 379 343 M18523 GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING.html Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. 6/17 Gene Ontology MF GO:0033612 6.86858693437682e-05 0.000159977214674093 560 366.272727272727 366 6.86879924230163e-06 10 2.67673725859819 3.10654690630789 1 19.9465733043822 560 229 762 113 366 598 519 285 10 179 408 344 M19095 GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a G-protein coupled receptor. 113/333 Gene Ontology MF GO:0001664 2.45783263450601e-08 7.5373534124851e-07 470 342 366 2.23439332905894e-09 26 1.87457602385195 1.99647126333394 1 22.5317432070481 470 112 26 266 51 772 467 505 366 70 657 345 M18094 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the epidermal growth factor receptor. 22/47 Gene Ontology MF GO:0005154 5.71508769015692e-05 0.000135164027633531 410 410.636363636364 367 5.19566923656926e-06 199 2.01841820432473 -2.36585239792158 -1 15.3309289982627 500 406 199 302 357 408 689 621 312 367 356 346 M18111 GO_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with an identical protein to form a homodimer. 398/1017 Gene Ontology MF GO:0042803 2.66750987654844e-06 1.25837303862175e-05 795 472.090909090909 367 2.42501191901967e-07 95 1.62263399434259 -1.38149818190156 -1 15.6090525378609 792 367 95 269 170 477 865 748 346 204 860 347 M18687 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. 19/37 Gene Ontology MF GO:0032266 0.00010790834481871 0.000234694272418943 210 367 367 9.81033072775626e-06 102 1.38582257985201 1.49819633310185 1 9.87409119657872 210 663 381 468 479 367 273 102 322 555 217 348 M19220 GO_COENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BINDING.html Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 101/214 Gene Ontology MF GO:0050662 1.94226552292914e-06 1.06055226959349e-05 200 349.454545454545 367 1.76569748877857e-07 104 1.43253870311311 -1.3465089726948 -1 13.9893004687151 197 655 424 593 141 104 367 260 462 505 136 349 M18813 GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS.html Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 33/63 Gene Ontology MF GO:0016879 0.00637088203901902 0.00968795285272314 260 490.272727272727 368 0.000580855121585951 258 1.13409186807595 -1.16688278740514 -1 4.4833295301063 258 766 365 881 556 296 291 368 620 647 345 350 M18497 GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 38/96 Gene Ontology MF GO:0004702 3.84933009483985e-05 9.78282786533885e-05 365 442 369 3.49945222549553e-06 166 1.23413307716575 -1.23723875436976 -1 9.71402155985361 735 216 363 364 333 540 693 634 449 369 166 351 M18351 GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. 17/37 Gene Ontology MF GO:0051119 0.000114712315252556 0.000247155339654219 200 385.363636363636 370 1.04289360922131e-05 165 1.74892559699509 1.95596995661996 1 12.3840896637685 533 165 197 210 387 703 596 329 200 370 549 352 M18652 GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). 9/33 Gene Ontology MF GO:0015298 0.000543090725312674 0.000985490073545681 470 403.727272727273 370 5.43223497374054e-05 287 2.44026574699199 -2.40866370853086 -1 14.4018849640215 354 470 791 388 466 295 403 370 288 287 329 353 M18388 GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 93/261 Gene Ontology MF GO:0005088 2.25651682881658e-06 1.15977401257612e-05 155 479 371 2.05138103936859e-07 126 1.44119551678542 -1.48104288016953 -1 13.9639472752955 738 126 152 243 154 880 679 808 371 231 887 354 M18573 GO_ACETYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_BINDING.html Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. 3/20 Gene Ontology MF GO:0042166 0.000130260969222665 0.000276766955392267 350 373.363636363636 372 1.30268605416694e-05 109 1.95916701446698 -1.95916701446698 -1 13.6837918452417 347 391 772 426 453 331 372 109 187 437 282 355 M18566 GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. 13/29 Gene Ontology MF GO:0015665 4.14187442938162e-05 0.000102987147973813 610 366.909090909091 373 3.76541128115671e-06 49 2.44720404451709 -2.18416527123717 -1 19.1550394530853 609 207 49 184 373 533 746 274 417 172 472 356 M18674 GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate into, out of or within a cell, or between cells. 23/47 Gene Ontology MF GO:1901476 6.10948539471935e-05 0.000143385881712801 540 381.181818181818 373 5.55423187645158e-06 70 2.15337552121883 2.28299780270412 1 16.2475893843285 540 133 70 231 360 727 450 409 373 282 618 357 M18790 GO_SIALYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. 6/21 Gene Ontology MF GO:0008373 0.0108984541647998 0.0160425245305854 200 414.181818181818 373 0.00109522753675182 103 1.84955840494846 -1.52785069628539 -1 6.51642666265696 198 418 818 445 634 297 103 373 699 341 230 358 M17852 GO_5_3_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_5_3_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. 4/12 Gene Ontology MF GO:0008409 0.00133192707143742 0.00228188623039558 175 407.636363636364 374 0.000133272605888431 76 0.665947705721474 -0.665947705721474 -1 3.45356474228569 171 306 609 553 646 76 128 374 707 772 142 359 M18182 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS.html Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. 19/47 Gene Ontology MF GO:0016706 0.00258721183551865 0.00424284293881846 295 381.818181818182 377 0.00023547812993809 144 1.70103627719114 1.91224268375373 1 7.92198583830107 293 691 377 400 690 254 144 461 299 430 161 360 M19001 GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. 10/30 Gene Ontology MF GO:0005242 9.46327169916382e-05 0.000212346584469042 380 446.090909090909 378 8.60334435008533e-06 197 1.23021797651113 1.37246841373087 1 8.8703476445346 644 375 295 402 378 625 323 376 557 197 735 361 M18471 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. 11/22 Gene Ontology MF GO:0016722 3.86324303830099e-05 9.79113938081793e-05 335 417.636363636364 379 3.51210079933848e-06 234 1.39685855818534 -1.405566970919 -1 10.9938435722746 419 331 367 379 335 507 631 559 234 352 480 362 M18494 GO_PHOSPHATIDYLSERINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_BINDING.html Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. 25/62 Gene Ontology MF GO:0001786 0.00492606849367377 0.00772058435124339 200 396.454545454545 382 0.00044883029666474 184 2.15411106026343 1.97960489625344 1 8.93258036029635 199 738 184 288 541 294 382 430 558 327 420 363 M18199 GO_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 20/52 Gene Ontology MF GO:0005504 0.00504272082311477 0.00785082576791548 385 393.909090909091 383 0.000459483336631414 104 2.66553273849409 2.74705364098074 1 11.0153065085728 383 354 104 149 544 576 676 539 274 330 404 364 M19227 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. 30/72 Gene Ontology MF GO:0043028 0.000992590333565351 0.00173200147334337 425 392.909090909091 383 9.02762228176082e-05 286 1.66602342509815 -1.61391373084677 -1 9.03153479544033 424 513 342 296 486 370 383 401 286 519 302 365 M18365 GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. 6/13 Gene Ontology MF GO:0004859 0.000349032575073308 0.000658012231695581 140 372.818181818182 384 3.49087407877012e-05 46 0.894071168205526 0.894071168205526 1 5.5844875389727 140 195 724 384 445 107 46 667 700 564 129 366 M18195 GO_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). 19/84 Gene Ontology MF GO:0015297 4.19117972209592e-05 0.000103932219523672 760 465.363636363636 387 3.81023597238465e-06 209 1.73031448774058 1.62194661685984 1 13.5302426782773 757 323 252 334 342 585 899 542 387 209 489 367 M18614 GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Increases the activity of a peptidase that is involved in the apoptotic process. 14/28 Gene Ontology MF GO:0016505 0.000184999982792435 0.000376548637542125 175 335.545454545455 387 1.68195946763119e-05 36 0.984480288815421 -1.05000518164031 -1 6.61769078188218 174 387 445 403 603 62 36 333 499 690 59 368 M18103 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. 5/12 Gene Ontology MF GO:0004865 2.21387282079371e-06 1.15725170177853e-05 755 433.363636363636 389 2.21387502635159e-07 2 2.81395541718928 -2.18725757471496 -1 27.2700355418937 755 241 665 43 161 766 793 389 2 150 802 369 M18097 GO_SERINE_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 88/379 Gene Ontology MF GO:0017171 1.10636489655562e-06 7.37576597703748e-06 875 463.090909090909 390 1.00578677539939e-07 41 1.86633033047145 -1.87351774897018 -1 18.8033176705965 874 145 41 390 102 605 904 887 298 98 750 370 M18711 GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. 29/83 Gene Ontology MF GO:0035004 2.4685525202077e-05 6.79960574428469e-05 310 368.636363636364 390 2.24416383592135e-06 172 1.80455975221488 1.89697391408808 1 14.7635762092311 390 393 172 307 310 522 440 377 239 402 503 371 M19100 GO_CARBON_OXYGEN_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_OXYGEN_LYASE_ACTIVITY.html Catalysis of the breakage of a carbon-oxygen bond. 44/77 Gene Ontology MF GO:0016835 4.68247912293413e-07 4.87603297698976e-06 505 379.181818181818 390 4.25680010868463e-08 47 1.02718679565781 -0.985551827820255 -1 10.7113705831971 504 57 348 339 47 332 540 420 574 620 390 372 M19226 GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. 22/59 Gene Ontology MF GO:0005544 4.74278685326916e-06 1.85675059787559e-05 870 447.090909090909 391 4.31163370714346e-07 39 1.6065041178394 -1.69784459001774 -1 14.9210852465974 869 39 126 289 211 677 805 795 391 184 532 373 M18037 GO_FMN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FMN_BINDING.html Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 6/14 Gene Ontology MF GO:0010181 0.000108801396889138 0.000236078502683978 270 442.909090909091 393 1.0880672424102e-05 218 1.23306911092324 -1.23306911092324 -1 8.77952891239561 269 517 647 578 390 218 269 393 788 559 244 374 M18485 GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of modified amino acids from one side of a membrane to the other. 6/17 Gene Ontology MF GO:0072349 0.000116715771487219 0.000250675295566918 320 481.454545454545 393 1.1672190209749e-05 72 1.66715583234834 1.40985940957344 1 11.7849803964004 745 72 751 365 393 897 567 319 316 178 693 375 M19084 GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING.html Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. 147/461 Gene Ontology MF GO:0001159 1.10479044006424e-06 7.37576597703748e-06 460 381.636363636364 393 1.00435544987773e-07 51 1.59736980863092 1.71968135285097 1 16.0935346936213 456 51 192 343 101 722 393 598 261 404 677 376 M19206 GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS.html Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. 7/13 Gene Ontology MF GO:0016801 0.000260136253252603 0.000507045239390667 395 413.727272727273 394 2.60166710162204e-05 127 1.99267758873986 -2.03107858600975 -1 12.889298986363 640 187 916 381 449 501 392 127 138 394 426 377 M17994 GO_CYCLIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_BINDING.html Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. 8/22 Gene Ontology MF GO:0030332 8.5475316440594e-05 0.00019368790917573 720 466.363636363636 395 8.54786043319577e-06 259 1.16243321926555 -0.897438056671142 -1 8.47274173785339 719 347 632 395 377 353 332 490 467 259 759 378 M18210 GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY.html Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 7/13 Gene Ontology MF GO:0009982 0.00844114942308622 0.0126686092483513 150 412.181818181818 396 0.000847338574600284 150 0.779005003883213 -0.779005003883213 -1 2.90143347479102 150 396 688 535 565 164 216 267 476 812 265 379 M18625 GO_DEATH_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). 16/23 Gene Ontology MF GO:0005123 6.73735014820476e-05 0.000157318835947928 555 451.181818181818 398 6.12505134891858e-06 240 1.10176975669753 -1.09590863395841 -1 8.22593379269439 552 346 391 440 362 398 616 886 441 240 291 380 M18638 GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. 9/21 Gene Ontology MF GO:0034236 0.011866875809336 0.0174123217617052 290 449.454545454545 398 0.00119307264497937 189 1.48962880236821 1.48962880236821 1 5.14425250476121 287 482 787 336 703 286 189 619 398 630 227 381 M18845 GO_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. 45/104 Gene Ontology MF GO:0008238 1.85480708720223e-05 5.43446662492374e-05 295 418.363636363636 399 1.686202477415e-06 251 1.49855780625756 1.54557045982199 1 12.5464122996033 291 320 336 770 287 554 507 251 472 399 415 382 M18392 GO_ENZYME_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of an enzyme. 250/550 Gene Ontology MF GO:0008047 1.9333214792369e-07 3.4993711490565e-06 905 504.181818181818 400 1.75756513557621e-08 14 1.42970048988929 -1.34883590749094 -1 15.3131036701719 903 214 259 391 14 581 908 914 400 188 774 383 M18569 GO_MICROFILAMENT_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROFILAMENT_MOTOR_ACTIVITY.html Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 4/31 Gene Ontology MF GO:0000146 3.19420777827089e-05 8.39620330288348e-05 280 417 400 3.19425369253473e-06 19 6.00900434550934 6.00900434550934 1 48.0807083182178 278 708 771 310 733 352 472 64 19 480 400 384 M18911 GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. 10/74 Gene Ontology MF GO:0005230 0.000167295158854793 0.000346647626455877 425 354.636363636364 400 1.52098074434159e-05 175 2.09825025633294 2.14461133695493 1 14.2524790713996 327 487 175 422 400 417 312 530 210 196 425 385 M18405 GO_NUCLEOSIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. 7/14 Gene Ontology MF GO:0019206 0.00150911626037962 0.00257108696212825 405 478.090909090909 401 0.00015101420853211 254 0.737827437083775 -0.793694991344058 -1 3.75126699830105 401 316 733 613 501 271 280 312 743 835 254 386 M18924 GO_SH3_SH2_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_SH2_ADAPTOR_ACTIVITY.html Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). 24/69 Gene Ontology MF GO:0005070 0.000167721528588215 0.000346750126519455 345 434.818181818182 401 1.52485742317361e-05 329 1.19188298498096 -0.990586568087137 -1 8.09562958401812 604 345 330 382 401 412 569 341 329 522 548 387 M18518 GO_CHANNEL_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_INHIBITOR_ACTIVITY.html Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 23/62 Gene Ontology MF GO:0016248 6.85362403004712e-06 2.44392794869897e-05 655 475.636363636364 404 6.23058671011194e-07 203 1.19340127073068 1.4091653901268 1 10.804644171854 651 203 368 226 235 729 771 562 404 398 685 388 M19036 GO_CYTOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_ACTIVITY.html Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 27/95 Gene Ontology MF GO:0004896 0.000174920626023852 0.000359211999870411 405 512.545454545455 404 1.59031395819913e-05 202 1.80475129951078 -1.92809702580026 -1 12.2040887684824 798 298 202 574 404 870 749 402 349 276 716 389 M18500 GO_MAP_KINASE_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_KINASE_ACTIVITY.html Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. 8/25 Gene Ontology MF GO:0004709 4.69558647087181e-06 1.85024700336877e-05 740 456.909090909091 405 4.69559639274085e-07 184 1.20892103493401 -1.00861178401138 -1 11.2319809705604 602 184 754 303 219 740 405 394 265 423 737 390 M17952 GO_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 13/38 Gene Ontology MF GO:0019212 1.92092180790266e-06 1.06055226959349e-05 645 396.272727272727 406 1.74629407740948e-07 9 1.67236531910195 -1.36100271431558 -1 16.3313011471422 642 223 275 147 140 532 715 647 9 406 623 391 M18994 GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. 44/84 Gene Ontology MF GO:0050660 2.30439451171032e-05 6.46354558162652e-05 410 401.363636363636 407 2.0949260449926e-06 87 1.52869537353602 -1.40562050592735 -1 12.5727178747033 407 493 281 575 305 261 637 512 485 372 87 392 M19137 GO_AMMONIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_BINDING.html Interacting selectively and non-covalently with ammonium ions (NH4+). 16/79 Gene Ontology MF GO:0070405 5.62535634600566e-07 5.19029108191918e-06 570 459.545454545455 407 5.11396162218058e-08 66 1.98646320720373 2.16195605514885 1 20.6088027769385 568 407 140 326 66 859 803 826 248 164 648 393 M18021 GO_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 39/105 Gene Ontology MF GO:0019210 8.11010970389414e-06 2.81928012264183e-05 755 542.090909090909 408 7.37285418296941e-07 97 1.38357480920968 1.33578232715381 1 12.3578764151705 752 97 284 363 240 857 901 825 408 395 841 394 M18341 GO_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. 20/106 Gene Ontology MF GO:0005253 5.06861483524939e-06 1.92691142497084e-05 675 380.272727272727 408 4.60784228449911e-07 61 1.57939321666447 -1.71468545043661 -1 14.6193377178243 674 432 222 408 218 521 581 61 161 331 574 395 M18285 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 232/695 Gene Ontology MF GO:0000981 4.20666230235086e-06 1.72005747473902e-05 555 442.636363636364 409 3.82424576910206e-07 99 1.546000186096 1.60098378048411 1 14.4599222172759 551 159 99 313 203 827 564 791 409 174 779 396 M18295 GO_CATION_SUGAR_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_SUGAR_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). 13/16 Gene Ontology MF GO:0005402 0.000102262780099602 0.000226673114732215 410 473.090909090909 409 9.29704853619489e-06 98 1.69530605159322 -1.47286645082861 -1 12.1294464247482 880 153 238 208 410 871 912 98 181 409 844 397 M18704 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 14/38 Gene Ontology MF GO:0097472 0.00610422530109984 0.00931324589885879 410 384.909090909091 409 0.00055647531476947 220 1.20492991463251 1.25059978739282 1 4.80389040750749 224 449 409 586 606 409 263 220 491 306 271 398 M19225 GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a nucleotidyl group to a reactant. 69/136 Gene Ontology MF GO:0016779 0.000188820672773097 0.000383476863027041 95 466 409 1.71669891583435e-05 91 0.998829678948242 -0.879056020763506 -1 6.69862176902597 91 812 594 861 409 159 245 264 619 744 328 399 M18348 GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. 163/410 Gene Ontology MF GO:0042578 2.36514157136329e-07 3.76504029521441e-06 330 427.181818181818 410 2.15012893239206e-08 22 1.4152407328568 -1.19832638174351 -1 15.0699373016823 461 327 327 739 22 668 410 515 399 277 554 400 M18432 GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 130/334 Gene Ontology MF GO:0005085 2.51126537448911e-06 1.2224148912857e-05 840 523.363636363636 410 2.28297112823963e-07 164 1.38932952496377 -1.43307712519875 -1 13.3991022618072 837 271 270 325 164 771 687 900 410 357 765 401 M18516 GO_HMG_BOX_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HMG_BOX_DOMAIN_BINDING.html Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. 9/22 Gene Ontology MF GO:0071837 0.00253784050019394 0.00416930939317577 415 457.818181818182 411 0.000254074345267542 309 1.50521150796795 1.916950511037 1 7.03243589808192 311 394 759 320 520 411 411 309 644 457 500 402 M18547 GO_AMIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BINDING.html Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 125/369 Gene Ontology MF GO:0033218 6.54655143807544e-06 2.36189306785467e-05 550 401.272727272727 412 5.95142810796704e-07 168 1.67032791066066 1.76933316536748 1 15.1711957143471 320 454 168 584 232 549 549 495 412 274 377 403 M18163 GO_METALLOEXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOEXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 17/53 Gene Ontology MF GO:0008235 0.000521650899250748 0.000950334311506313 360 472.363636363636 413 4.74340573710483e-05 283 2.24882505544217 2.48388915362939 1 13.3416914163362 358 361 294 550 458 753 814 283 406 506 413 404 M18655 GO_ANNEALING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANNEALING_ACTIVITY.html A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide. 7/15 Gene Ontology MF GO:0097617 0.0386896376890355 0.0524218949542159 230 481.636363636364 413 0.00393802202316157 224 3.87235545331848 3.87235545331848 1 9.73404800286099 227 744 793 473 878 413 357 304 224 595 290 405 M18131 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol phosphate. 75/175 Gene Ontology MF GO:1901981 2.68088169097677e-06 1.25837303862175e-05 545 473.909090909091 414 2.43716814350735e-07 171 1.58448161747134 -1.86975584575006 -1 15.2420428112196 545 442 258 215 171 702 376 812 401 414 877 406 M18522 GO_MANNOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 12/22 Gene Ontology MF GO:0000030 0.00216576704125436 0.00358364330567269 225 448.090909090909 414 0.00019708200464546 175 0.561699912174943 -0.561699912174943 -1 2.69678377583819 222 414 518 661 513 175 296 286 719 847 278 407 M18853 GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). 4/18 Gene Ontology MF GO:0016775 0.00916249351166402 0.013639957978529 380 481.181818181818 414 0.000920049228060441 244 1.17879935449437 -1.17879935449437 -1 4.3162367120799 379 343 829 414 569 263 244 666 748 484 354 408 M17980 GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. 2/15 Gene Ontology MF GO:0047555 0.136735800143236 0.160455275678287 300 453.9 415 0.0162044382354522 237 1.38329240566274 1.38329240566274 1 2.15789682837589 299 462 628 NA 680 368 237 397 674 361 433 409 M18268 GO_ALCOHOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BINDING.html Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. 40/136 Gene Ontology MF GO:0043178 4.09725757259313e-06 1.69072096537381e-05 515 366.090909090909 415 3.72478654845797e-07 115 1.43638316244494 -1.39005702408312 -1 13.4557277919691 512 115 224 273 200 415 695 444 446 186 517 410 M18714 GO_STEROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a steroid hormone receptor. 46/118 Gene Ontology MF GO:0035258 1.09872313064196e-06 7.37576597703748e-06 435 395.909090909091 415 9.98839708514741e-08 100 1.38047621513438 -1.27842031625526 -1 13.9083271269123 431 603 358 125 100 204 434 851 415 499 335 411 M18991 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/50 Gene Ontology MF GO:0016667 0.0107033989322197 0.0158059823718172 280 520.727272727273 415 0.000977802762026248 243 1.04461964800597 -1.04461964800597 -1 3.69366868190378 279 827 415 794 798 278 364 244 808 678 243 412 M18780 GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. 12/29 Gene Ontology MF GO:0015605 1.93107507796462e-05 5.58675808719324e-05 820 467.363636363636 418 1.75553820764049e-06 64 0.89266295301856 -0.67529576188881 -1 7.45263009024998 817 64 418 192 292 760 460 606 284 380 868 413 M18429 GO_RAB_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GTPASE_BINDING.html Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. 66/135 Gene Ontology MF GO:0017137 1.05847635549448e-06 7.30369229697438e-06 655 465 419 9.62251695231736e-08 95 1.32058902903452 -1.2571253331596 -1 13.3160183802144 654 95 378 338 97 520 893 857 419 313 551 414 M18846 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. 12/25 Gene Ontology MF GO:0015215 1.93107507796462e-05 5.58675808719324e-05 820 467.363636363636 419 1.75553820764049e-06 65 0.89266295301856 -0.67529576188881 -1 7.45263009024998 818 65 419 193 293 761 461 596 285 381 869 415 M18137 GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic hydroxy compound from one side of the membrane to the other. 27/92 Gene Ontology MF GO:1901618 2.77767672243362e-07 3.7799829111349e-06 670 432.090909090909 421 2.52516097557972e-08 32 2.29455166217477 -2.24602298128997 -1 24.4253736268352 667 295 32 196 421 636 896 481 395 88 646 416 M18218 GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. 8/12 Gene Ontology MF GO:0052743 0.00540820824890561 0.00834824092112947 340 455.818181818182 421 0.000542141543102591 216 0.825867915950773 -0.916650515732891 -1 3.36964204521554 336 452 691 511 848 224 316 216 737 421 262 417 M18543 GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. 50/118 Gene Ontology MF GO:1902936 1.481345379561e-05 4.57601954572069e-05 425 411.272727272727 421 1.34668668557124e-06 109 1.814091012742 -2.30570869966601 -1 15.454073663434 515 422 196 109 275 615 421 551 340 312 768 418 M17894 GO_PHOSPHOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_BINDING.html Interacting selectively and non-covalently with a phosphorylated protein. 40/84 Gene Ontology MF GO:0051219 2.30763176143691e-06 1.16649517611096e-05 710 475.272727272727 422 2.0978492563361e-07 157 1.55278199125086 1.65043988216602 1 15.0374745619175 710 370 325 255 157 900 577 468 422 185 859 419 M18981 GO_LIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BINDING.html Interacting selectively and non-covalently with a lipid. 309/886 Gene Ontology MF GO:0008289 4.47949205106224e-07 4.87603297698976e-06 555 449.909090909091 424 4.07226633013322e-08 44 1.57882094371989 -1.56178810909278 -1 16.4637399325235 553 242 87 280 44 919 539 865 424 156 840 420 M18535 GO_LIGASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_REGULATOR_ACTIVITY.html Modulates the activity of a ligase. 8/20 Gene Ontology MF GO:0055103 0.00588401897262029 0.00900715050717249 195 422 425 0.000589965703577336 148 1.13113073759219 -1.13113073759219 -1 4.54189113175507 192 269 765 449 563 148 255 652 724 425 200 421 M18143 GO_LYSOPHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPASE_ACTIVITY.html Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. 9/23 Gene Ontology MF GO:0004622 8.18224648452392e-05 0.000185868315204 860 546.454545454545 426 8.1825477713459e-06 285 1.38565202914609 -1.07998060106765 -1 10.1484221423522 858 426 673 353 374 765 757 418 356 285 746 422 M18599 GO_CGMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BINDING.html Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). 4/19 Gene Ontology MF GO:0030553 0.00383703325996038 0.00609684041306312 340 426.545454545455 427 0.000384367467600071 72 2.81387976779438 2.81387976779438 1 12.2349362947271 339 686 778 319 677 456 427 208 72 481 249 423 M17933 GO_STEROID_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_DEHYDROGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. 14/53 Gene Ontology MF GO:0016229 0.0021226762302771 0.00352502189865512 690 449.181818181818 430 0.000193157006477088 158 1.32935057600287 -1.32935057600287 -1 6.40105297862553 256 804 430 686 624 158 191 185 642 686 279 424 M18914 GO_CXCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CXCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. 6/15 Gene Ontology MF GO:0045236 0.000192117923085973 0.000389313852949548 395 449.454545454545 430 1.92134534290538e-05 181 2.0012322041596 2.03518377629462 1 13.3954303316775 395 435 848 522 416 430 439 421 517 181 340 425 M18613 GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 10/41 Gene Ontology MF GO:0015125 0.000271825854148737 0.000526483759614395 85 454.818181818182 431 2.47144950911615e-05 82 2.14189927983246 -2.32849992802703 -1 13.7858157068113 799 267 82 190 431 691 608 804 279 85 767 426 M18376 GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS.html Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). 12/20 Gene Ontology MF GO:0016780 5.17260854468538e-05 0.000123927079716421 505 400.454545454545 432 4.702481969383e-06 79 1.1670562309278 -1.1670562309278 -1 8.95075591038382 302 502 432 717 504 201 328 79 650 545 145 427 M18399 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS.html Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). 114/262 Gene Ontology MF GO:0016746 0.000274524661027618 0.000530593882658422 215 433.363636363636 432 2.4959902116478e-05 39 1.14707429804764 -1.13017746063725 -1 7.37526072893889 215 786 575 882 432 39 210 186 593 712 137 428 M19192 GO_ARMADILLO_REPEAT_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARMADILLO_REPEAT_DOMAIN_BINDING.html Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. 5/19 Gene Ontology MF GO:0070016 0.0651361260434808 0.0844938027706233 360 514.909090909091 433 0.00671280276339293 236 1.54539616595905 1.54539616595905 1 3.25576781080865 356 419 912 524 901 429 236 433 598 530 326 429 M18738 GO_TASTE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TASTE_RECEPTOR_ACTIVITY.html Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. 2/40 Gene Ontology MF GO:0008527 1.3361162493787e-05 4.22414759253748e-05 635 440.8 433.5 1.48458242633016e-06 45 1.20257855897392 -1.03504655916583 -1 10.3266899771053 633 107 804 NA 456 843 816 45 158 135 411 430 M18249 GO_PHOSPHATIDYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BINDING.html Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. 6/28 Gene Ontology MF GO:0031210 0.00180178403516389 0.00302716664379526 515 461.090909090909 434 0.000180324659598088 317 1.47720758992063 -1.64912560768185 -1 7.30476806377486 514 434 697 317 507 426 358 408 544 337 530 431 M18688 GO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 95/190 Gene Ontology MF GO:0016829 5.30364639188742e-07 5.13360214597281e-06 560 442.454545454545 434 4.82149788223958e-08 59 1.14399417168278 -1.07975942458477 -1 11.8792170959496 556 244 282 573 59 434 844 305 599 605 366 432 M18381 GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. 10/24 Gene Ontology MF GO:0005385 0.00500627920893833 0.0078196551311091 295 438.818181818182 437 0.000456155257378399 137 1.71370050351992 1.85356303270891 1 7.08767486205846 688 137 291 291 543 696 437 514 238 320 672 433 M18936 GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. 8/27 Gene Ontology MF GO:0043325 0.000168521150298253 0.000347622103754245 520 445.636363636364 438 1.68533931382544e-05 24 2.17626394926688 -2.630486763609 -1 14.7771828305544 518 239 857 24 407 672 551 513 420 263 438 434 M18980 GO_APOLIPOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOLIPOPROTEIN_BINDING.html Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex. 7/26 Gene Ontology MF GO:0034185 0.000460382044421397 0.000850504981662019 245 433.090909090909 438 4.60477450472691e-05 94 1.23841624838389 1.23841624838389 1 7.4643797104783 242 339 865 119 574 438 663 479 725 226 94 435 M18923 GO_DOPAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_BINDING.html Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. 3/12 Gene Ontology MF GO:0035240 0.00155032694897971 0.00263155127871095 230 428.818181818182 439 0.000155140959329285 129 1.0818214294583 1.0818214294583 1 5.47876434063586 229 550 851 457 665 319 129 175 677 439 226 436 M18898 GO_CULLIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). 7/16 Gene Ontology MF GO:0097602 0.0178760152878615 0.0255768803496619 305 508.363636363636 440 0.00180214630605494 112 1.07061941509854 1.07061941509854 1 3.34628362493469 301 701 843 685 694 330 112 440 708 392 386 437 M18918 GO_SIGNALING_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. 35/96 Gene Ontology MF GO:0035591 0.000193277534926447 0.000389945903798973 920 572 441 1.7572228828056e-05 276 1.12478553206009 1.23981321546547 1 7.52729893496522 918 430 407 441 412 651 898 276 438 658 763 438 M18865 GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. 24/52 Gene Ontology MF GO:0008375 1.60929875297282e-05 4.90249951236752e-05 690 487.727272727273 442 1.46300956827694e-06 179 1.27793870940441 -1.57761995778423 -1 10.8115563665178 687 321 442 362 277 632 418 704 179 521 822 439 M18038 GO_ADENYLYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an adenylyl group to an acceptor. 14/34 Gene Ontology MF GO:0070566 0.000363601380979779 0.000678525903653948 180 403.454545454545 443 3.30601353189268e-05 105 0.921129587425118 -0.921129587425118 -1 5.72938930790314 178 466 512 651 443 105 149 365 625 688 256 440 M18752 GO_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any chemokine receptor. 22/77 Gene Ontology MF GO:0042379 0.000102495669270219 0.000226673114732215 415 442 444 9.31822224966775e-06 188 1.83152440371254 1.9973543504976 1 13.1040511078773 415 444 188 706 382 584 451 282 603 272 535 441 M18423 GO_14_3_3_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_14_3_3_PROTEIN_BINDING.html Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. 17/67 Gene Ontology MF GO:0071889 0.00102795730180163 0.00178437871256132 275 427.636363636364 445 9.3494357518093e-05 193 1.12871785188497 0.958345482824546 1 6.09012462070487 275 445 328 470 489 320 193 577 572 625 410 442 M18736 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 52/149 Gene Ontology MF GO:0001078 2.32724182894825e-05 6.48807352534299e-05 910 575.636363636364 445 2.11569677067503e-06 245 1.44333853800474 1.54517723554404 1 11.8660418256068 909 245 301 367 306 692 894 860 445 412 901 443 M18465 GO_MOLECULAR_FUNCTION_REGULATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLECULAR_FUNCTION_REGULATOR.html A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators. 622/1627 Gene Ontology MF GO:0098772 1.97412685627629e-07 3.4993711490565e-06 450 384.090909090909 447 1.97412703164926e-08 2 1.5234153888519 1.62857998392505 1 16.3168565417907 447 2 746 126 19 875 514 555 276 22 643 444 M18606 GO_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. 20/49 Gene Ontology MF GO:0008374 0.000338515571283339 0.00064213263006324 450 428.181818181818 447 3.07788791035905e-05 131 1.8092952776341 -1.63733653983789 -1 11.3387814603217 663 431 332 491 447 407 595 131 249 449 515 445 M18755 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. 54/216 Gene Ontology MF GO:0016705 0.000519026304899396 0.000947428969260803 345 419.727272727273 447 4.71953449625442e-05 142 1.8345179162081 2.22978169926492 1 10.8885042936317 341 579 142 533 457 502 334 403 428 447 451 446 M19037 GO_ACID_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. 3/12 Gene Ontology MF GO:0003993 0.000102472395980207 0.000226673114732215 230 448.727272727273 447 1.02477121553268e-05 16 0.802326884390139 -0.802326884390139 -1 5.74042714245273 226 447 873 527 687 153 16 141 816 893 157 447 M17865 GO_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. 248/804 Gene Ontology MF GO:0008233 4.50713086361878e-06 1.80285234544751e-05 530 426.272727272727 448 4.09740008853231e-07 60 1.57236544292938 -1.45209445806282 -1 14.643497505087 528 463 288 890 206 60 448 699 416 469 222 448 M18446 GO_LIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 8/19 Gene Ontology MF GO:0055102 0.000381122301565886 0.000708348520082051 235 396.636363636364 448 3.81187681741676e-05 31 0.894071168205526 0.894071168205526 1 5.5282997691176 231 390 742 456 448 168 31 497 684 607 109 449 M18907 GO_PDZ_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PDZ_DOMAIN_BINDING.html Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. 53/141 Gene Ontology MF GO:0030165 6.06262974582949e-06 2.24000777757556e-05 490 431.454545454545 448 5.51149677539096e-07 99 1.49203247428215 1.57507058309785 1 13.6191788246724 490 448 223 282 227 752 470 785 372 99 598 450 M19060 GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. 3/11 Gene Ontology MF GO:0008331 0.0104477323520344 0.0154532375624947 250 466.454545454545 449 0.00104971796549236 101 1.5596974781972 1.5596974781972 1 5.54494373059812 250 506 883 458 651 310 101 336 746 441 449 451 M17971 GO_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for hormones. 89/307 Gene Ontology MF GO:0051427 2.35542997086861e-06 1.17584608956251e-05 725 523.636363636364 450 2.14130226610315e-07 81 1.40741555754694 1.57382306254553 1 13.6201343152034 724 403 394 81 158 837 913 585 368 450 847 452 M18668 GO_RRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_BINDING.html Interacting selectively and non-covalently with ribosomal RNA. 42/89 Gene Ontology MF GO:0019843 0.0839184282471183 0.101186047165595 355 518.727272727273 450 0.00793650793650794 306 1.45517260957721 -1.35017730544365 -1 2.84202519873066 355 779 584 715 670 328 306 371 423 725 450 453 M19150 GO_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOMERASE_ACTIVITY.html Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. 75/174 Gene Ontology MF GO:0016853 6.27360997477588e-06 2.28131271810032e-05 675 472.181818181818 451 5.70329805902735e-07 230 1.42868160579739 -1.26288057432159 -1 13.0186603522 675 297 374 506 230 325 672 743 451 296 625 454 M18474 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. 6/10 Gene Ontology MF GO:0016723 0.00603511580895437 0.00922310057182395 230 411.181818181818 452 0.000605156891183658 195 1.4883684629838 -1.4883684629838 -1 5.94626320539078 195 523 749 452 557 228 456 316 228 566 253 455 M18534 GO_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVITY.html Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 130/313 Gene Ontology MF GO:0016791 3.63254113609343e-07 4.42506727776583e-06 560 496.909090909091 452 3.30231066898403e-08 36 1.37757163293884 -1.05815063458772 -1 14.4791163044902 559 420 412 824 36 878 441 466 382 452 596 456 M18721 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY.html Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. 10/21 Gene Ontology MF GO:0030228 0.0353484982422178 0.0482501756421964 455 485.363636363636 453 0.00326632491116213 194 1.1542443637515 1.14240148762895 1 2.98305992440925 451 363 201 301 616 653 847 453 755 194 505 457 M18252 GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS.html Catalysis of the hydrolysis of any ester bond. 329/826 Gene Ontology MF GO:0016788 4.74467938290354e-07 4.87603297698976e-06 590 454 454 4.31334582379616e-08 48 1.35396160443951 -1.21456364716036 -1 14.1189359066483 589 409 469 877 48 147 721 454 376 623 281 458 M17960 GO_SYNTAXIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_BINDING.html Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. 48/123 Gene Ontology MF GO:0019905 2.02591517028152e-05 5.79204186045673e-05 635 457.818181818182 455 1.84175802416168e-06 246 1.19982058673474 -1.04377998183954 -1 9.9801029861253 631 246 417 398 297 469 704 487 573 359 455 459 M19021 GO_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. 189/493 Gene Ontology MF GO:0005543 3.83110573865653e-07 4.49709854751353e-06 580 469.909090909091 457 3.48282400528176e-08 39 1.53961658196317 -1.64889510717709 -1 16.1611125186013 580 293 129 261 39 896 492 912 457 208 902 460 M18435 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a functional group from one position to another within a single molecule. 13/27 Gene Ontology MF GO:0016866 0.00105704704741277 0.00183141861321986 375 447.363636363636 458 9.61413886342756e-05 200 1.27610040717449 -0.779005003883213 -1 6.8570345623384 373 330 473 519 491 243 200 901 252 681 458 461 M18132 GO_GTPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. 8/20 Gene Ontology MF GO:0005095 0.000558293078318804 0.00100514605098493 545 487.454545454545 459 5.58433388955751e-05 208 1.10816690832455 -1.49312590575049 -1 6.52148654335138 544 208 668 246 469 689 885 459 430 418 346 462 M18286 GO_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. 115/269 Gene Ontology MF GO:0035091 1.24275564229373e-06 7.8990748368896e-06 430 493.181818181818 459 1.12977849483017e-07 112 1.53536364088107 -1.71206545041221 -1 15.379094894562 760 429 225 318 112 853 486 631 459 429 723 463 M19168 GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. 4/61 Gene Ontology MF GO:0008391 0.0339609842875226 0.0465634955954111 205 488.636363636364 460 0.0034491436557478 201 1.08861813587471 -1.08861813587471 -1 2.84647856333432 201 460 904 658 783 220 232 289 767 487 374 464 M18959 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. 44/103 Gene Ontology MF GO:0016811 0.00045758085225887 0.000847030953879597 385 486.090909090909 461 4.1606913892361e-05 207 1.2612254821011 -1.16772681814912 -1 7.6062602973276 382 662 461 720 450 207 377 632 530 619 307 465 M17851 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. 12/27 Gene Ontology MF GO:0016814 0.0633774695603107 0.0823549039484264 375 484.636363636364 462 0.0059345864468246 338 1.19098903039746 1.28144853610755 1 2.535154458769 427 372 354 640 638 526 338 462 539 373 662 466 M18011 GO_DIACYLGLYCEROL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_KINASE_ACTIVITY.html Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. 5/11 Gene Ontology MF GO:0004143 0.0434288687354913 0.0579892006337475 260 474.818181818182 463 0.00443017038305869 234 1.40504416121883 -1.3533733545236 -1 3.41099259931245 716 259 637 406 628 613 234 463 256 297 714 467 M18456 GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. 90/211 Gene Ontology MF GO:0004721 2.7039446072865e-07 3.7799829111349e-06 650 445.727272727273 463 2.45813176329012e-08 27 1.39996321188491 -1.06029777811563 -1 14.9025297584859 491 369 414 648 27 667 275 648 333 463 568 468 M18539 GO_CAMP_RESPONSE_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_RESPONSE_ELEMENT_BINDING.html Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. 8/16 Gene Ontology MF GO:0035497 0.000213565832844798 0.000426281583935933 655 519.727272727273 463 2.13586360285591e-05 145 0.693359858046117 0.738860871335291 1 4.58744309576947 653 326 766 240 419 463 145 375 704 849 777 469 M18560 GO_MYOSIN_HEAVY_CHAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_HEAVY_CHAIN_BINDING.html Interacting selectively and non-covalently with a heavy chain of a myosin complex. 11/27 Gene Ontology MF GO:0032036 3.22562699249496e-06 1.43361199666443e-05 705 456.727272727273 463 2.93239247445445e-07 45 1.15108865389084 -1.36882658644704 -1 10.9450363049949 701 45 331 463 187 579 362 438 487 512 919 470 M18797 GO_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. 291/803 Gene Ontology MF GO:0008134 3.74185915155023e-06 1.60864972870384e-05 465 494.181818181818 463 3.40169592353461e-07 194 1.39416527279259 1.64689276337917 1 13.1193851089097 463 512 375 711 194 785 428 382 439 676 471 471 M17871 GO_MHC_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the major histocompatibility complex. 15/33 Gene Ontology MF GO:0023023 0.054646353025181 0.0720267117237343 470 469.727272727273 464 0.00509571727521334 228 2.14990686434098 -2.14990686434098 -1 4.82193427086688 467 617 256 228 918 393 602 358 551 464 313 472 M18836 GO_CARBONATE_DEHYDRATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBONATE_DEHYDRATASE_ACTIVITY.html Catalysis of the reaction: H2CO3 = CO2 + H2O. 8/14 Gene Ontology MF GO:0004089 1.2249773945957e-05 3.92675680497575e-05 455 485.090909090909 464 1.22498414721136e-06 71 1.63398548794879 -1.99298963381198 -1 14.1329341503421 455 71 826 230 268 697 674 759 466 426 464 473 M18177 GO_R_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_R_SMAD_BINDING.html Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. 15/30 Gene Ontology MF GO:0070412 0.00156957189141523 0.00265931149190058 180 423.363636363636 465 0.000142790255392285 56 1.54789815603919 1.54789815603919 1 7.82530972829516 176 857 431 669 644 156 56 541 518 465 144 474 M18505 GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the class II major histocompatibility complex. 15/28 Gene Ontology MF GO:0023026 0.054646353025181 0.0720267117237343 470 471 466 0.00509571727521334 229 2.14990686434098 -2.14990686434098 -1 4.82193427086688 468 618 257 229 919 394 603 361 552 466 314 475 M18586 GO_ALKALI_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALI_METAL_ION_BINDING.html Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. 14/43 Gene Ontology MF GO:0031420 5.69576593116439e-06 2.1301238441753e-05 550 419.272727272727 466 5.17798243406148e-07 195 1.66907222637092 -1.84340119355763 -1 15.3067619680786 585 257 244 195 222 546 740 547 505 305 466 476 M17945 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). 8/29 Gene Ontology MF GO:0005104 0.000475833062926241 0.000875532835784283 565 512.818181818182 467 4.75934981338507e-05 337 1.16345606693709 -1.28207297328269 -1 6.98379966558511 563 337 624 467 459 440 381 733 495 416 726 477 M18032 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 73/223 Gene Ontology MF GO:0001227 9.16768220815555e-05 0.000206216812506188 400 453 467 8.33460387229284e-06 253 1.44239979064742 1.58636592320525 1 10.4362817542082 399 280 253 447 376 592 600 535 481 467 553 478 M18557 GO_SUMO_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. 10/17 Gene Ontology MF GO:0019789 0.10244562118659 0.121769989007316 430 541.818181818182 468 0.00977748391432926 198 0.776781783799484 0.776781783799484 1 1.39446170331083 426 619 468 653 746 359 198 391 813 851 436 479 M18730 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. 12/30 Gene Ontology MF GO:0016628 0.0423314655810876 0.0567710617122458 470 495.090909090909 468 0.00392442092279345 240 0.918070375946041 -0.814221486124961 -1 2.24539486987184 398 634 466 674 625 258 240 412 723 548 468 480 M18552 GO_MODIFIED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a modified amino acid. 45/101 Gene Ontology MF GO:0072341 2.33222140921555e-05 6.48807352534299e-05 280 403.090909090909 469 2.12022375770599e-06 141 1.7988477490492 1.50074299341862 1 14.7887706870682 277 499 141 474 307 343 489 710 469 246 479 481 M18713 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. 19/43 Gene Ontology MF GO:0044390 0.000253631544690319 0.000496470257691688 420 470.727272727273 471 2.30600718042932e-05 211 0.909597648519295 -0.802249804133131 -1 5.89992371380049 417 571 463 631 425 211 490 471 666 556 277 482 M19139 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. 63/141 Gene Ontology MF GO:0001085 0.000165524876830276 0.000343753694545946 575 513.454545454545 471 1.50488483635453e-05 290 1.58771097455477 2.06532985749642 1 10.795961153619 575 661 310 471 399 657 290 439 421 655 770 483 M18420 GO_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. 26/149 Gene Ontology MF GO:0004497 0.000225953630977206 0.000448011509696184 485 446.545454545455 472 2.05433491956838e-05 85 2.20394496965663 2.79334897299387 1 14.4884321861731 448 485 85 481 417 642 543 472 396 343 600 484 M19190 GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. 64/150 Gene Ontology MF GO:0001046 0.000710229482705255 0.00125898097126943 700 509.909090909091 473 6.45871700814031e-05 232 1.69489375642026 -1.26053205122941 -1 9.64896221080148 699 492 232 444 473 419 733 875 338 501 403 485 M18508 GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the rate of NTP hydrolysis by a NTPase. 173/380 Gene Ontology MF GO:0060589 5.54210468828719e-08 1.45678180377835e-06 540 432.090909090909 474 5.03827711627317e-09 3 1.34149863728921 1.36721020448684 1 15.370697476553 538 30 263 415 3 860 474 611 479 271 809 486 M19028 GO_GTP_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. 14/22 Gene Ontology MF GO:0030742 0.00227239498187873 0.00375332743865068 115 437.818181818182 474 0.000206795050356732 102 0.95664639817981 -0.95664639817981 -1 4.55523379539805 113 756 474 772 719 102 147 191 626 692 224 487 M19023 GO_C_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. 6/20 Gene Ontology MF GO:0016408 0.0137885920386672 0.0200402917465621 310 491.090909090909 475 0.0013874903105138 120 0.541338845523389 -0.541338845523389 -1 1.80457277248977 310 318 871 475 580 149 120 727 661 892 299 488 M18374 GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY.html Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. 7/12 Gene Ontology MF GO:0031543 0.0406986413872092 0.0548210103605161 320 463.909090909091 476 0.00414638101639698 155 1.27874623617648 1.5201688782984 1 3.165633878177 319 557 727 476 704 265 155 519 696 389 296 489 M18130 GO_ATPASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_REGULATOR_ACTIVITY.html Modulates the rate of ATP hydrolysis by an ATPase. 21/45 Gene Ontology MF GO:0060590 2.06634387335957e-06 1.11006000577223e-05 555 461 477 1.87849619469987e-07 145 0.996890677788744 0.70980849898032 1 9.69625044889822 555 248 494 295 145 711 477 342 429 673 702 490 M18753 GO_PROLINE_RICH_REGION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROLINE_RICH_REGION_BINDING.html Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. 13/26 Gene Ontology MF GO:0070064 0.0032309174656608 0.00520709262955857 325 487.272727272727 477 0.000294152015095612 322 1.06303787180551 0.988215536361247 1 4.7651285429611 322 750 477 632 526 346 401 442 504 575 385 491 M18906 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. 9/30 Gene Ontology MF GO:0031435 7.38224817973183e-05 0.000170644932797821 425 529.363636363636 477 7.38249343034525e-06 368 0.842438129664558 -0.829466351138769 -1 6.23133557881543 475 477 846 424 368 397 617 580 582 634 423 492 M18207 GO_CALCIUM_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. 36/103 Gene Ontology MF GO:0048306 0.000112958766607523 0.000244522506538639 480 480.363636363636 478 1.02695060800323e-05 305 1.26454902764946 -0.941535069243075 -1 8.96577990648775 478 329 305 521 385 575 438 630 610 432 581 493 M18372 GO_HSP90_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP90_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. 16/38 Gene Ontology MF GO:0051879 0.000351890706697578 0.000660692755432188 590 371 478 3.19951822123918e-05 86 1.08105571371871 1.41759422133646 1 6.74867097171152 160 590 478 582 511 125 86 132 590 704 123 494 M19117 GO_RECEPTOR_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INHIBITOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. 5/14 Gene Ontology MF GO:0030547 0.00850598289900586 0.0127451209561651 455 495.636363636364 478 0.000853871766862424 285 1.29663211000844 0.964303468261184 1 4.82269885926944 452 285 897 293 566 478 488 474 538 303 678 495 M18303 GO_E_BOX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_E_BOX_BINDING.html Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. 12/40 Gene Ontology MF GO:0070888 0.0141630973389631 0.020552128630672 320 425.090909090909 479 0.00129591876969327 222 1.28495165825559 -0.946461091351904 -1 4.25580504596514 317 399 243 479 589 222 481 522 653 542 229 496 M18113 GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. 15/37 Gene Ontology MF GO:0045309 0.0156516132190556 0.0225344040086559 615 470.181818181818 480 0.00143309876679444 239 1.29956426819724 -1.57202681543269 -1 4.20218278600441 402 722 497 430 611 241 480 338 612 600 239 497 M18866 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. 9/23 Gene Ontology MF GO:0016863 0.0350874238220799 0.0479649775873901 320 476.727272727273 480 0.00356540642816149 164 0.816312530913905 -0.94657222479368 -1 2.11382574730726 316 555 832 480 619 234 164 335 766 632 311 498 M19026 GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY.html Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 5/26 Gene Ontology MF GO:0001637 0.0765897756730953 0.0971897843024106 460 538.363636363636 482 0.00793650793650794 302 1.72923944621836 -1.06639996039528 -1 3.43669836005185 460 613 872 508 759 482 317 782 384 302 443 499 M18007 GO_NEUROPEPTIDE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neuropeptide receptor. 3/31 Gene Ontology MF GO:0071855 0.0295638839312093 0.0410237906737747 335 476.545454545455 483 0.00299647202239664 195 1.22001810681507 -1.22001810681507 -1 3.32180795861989 334 584 635 629 615 195 265 483 747 434 321 500 M18140 GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). 5/20 Gene Ontology MF GO:0015299 0.000860534999762538 0.00151086297668232 580 444.363636363636 484 8.6086841570902e-05 112 2.74978352963736 -2.99609723536049 -1 15.2268454485315 577 365 671 355 484 496 537 548 112 298 445 501 M18794 GO_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_ACTIVITY.html Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. 40/144 Gene Ontology MF GO:0003774 0.0839184282471183 0.101186047165595 450 487.363636363636 485 0.00793650793650794 242 1.47674308752835 -1.34488199089819 -1 2.88415342706597 446 488 242 614 818 339 261 485 388 693 587 502 M18871 GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. 4/12 Gene Ontology MF GO:0010857 0.00265953560590492 0.00434595516417856 725 468.090909090909 485 0.00026627238858047 95 1.56675263701753 -2.43571715753574 -1 7.26453216157365 721 342 835 162 522 762 565 233 95 485 427 503 M18234 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells. 19/39 Gene Ontology MF GO:1901505 2.89758980003463e-05 7.70457403477416e-05 715 509.545454545455 487 2.63420724045078e-06 117 0.84533141083879 -0.688638882001258 -1 6.82582663617874 711 117 487 274 321 822 485 467 531 554 836 504 M18999 GO_PROTEIN_N_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 62/154 Gene Ontology MF GO:0047485 0.00127038621056964 0.0021805136450076 360 486.818181818182 488 0.000115556398772309 164 1.54001183420001 1.60141464927193 1 8.04607227841341 360 703 488 703 493 556 435 411 164 685 357 505 M17917 GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 87/194 Gene Ontology MF GO:0008234 0.00759843510972584 0.0114976320739273 490 518.909090909091 489 0.000693164222534679 176 1.51278639273599 -1.31194948692906 -1 5.75951764613408 489 793 413 802 560 176 353 701 455 700 266 506 M18748 GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any N-glycosyl bond. 9/26 Gene Ontology MF GO:0016799 0.214139132665174 0.243520398086477 485 541.909090909091 489 0.0238095238095238 353 1.22541578923111 1.22541578923111 1 1.47576087265247 353 483 807 483 681 489 504 525 688 460 488 507 M18261 GO_VITAMIN_D_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. 8/22 Gene Ontology MF GO:0042809 2.88060880302472e-05 7.68821161950527e-05 800 577.909090909091 491 2.88064614428781e-06 286 1.0659950721469 0.858943452531329 1 8.60955928067247 800 303 700 286 323 793 491 917 489 422 833 508 M18857 GO_SNARE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_BINDING.html Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 68/160 Gene Ontology MF GO:0000149 2.55629221938871e-05 7.00669630750418e-05 505 483.636363636364 491 2.32392902066831e-06 312 1.2591003357037 -1.16915422649698 -1 10.2688240275284 501 491 480 635 312 372 681 337 588 536 387 509 M17900 GO_QUINONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_BINDING.html Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. 12/20 Gene Ontology MF GO:0048038 9.06550338449664e-05 0.000204418213571983 555 457.363636363636 492 8.24170633339796e-06 185 2.95666358337178 -2.64501903660216 -1 21.4146076342022 610 554 185 747 375 492 314 587 241 374 552 510 M19029 GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 117/338 Gene Ontology MF GO:0003714 9.01217702997739e-06 3.07610033454681e-05 495 463.272727272727 493 8.19292177097144e-07 246 1.39669303670861 1.36191934002493 1 12.3712336722397 403 541 410 609 246 493 318 405 493 683 495 511 M18802 GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. 23/61 Gene Ontology MF GO:0005548 0.00310433070789193 0.00501930448376199 655 454.909090909091 494 0.000282610888721672 262 1.8223123077729 -1.58353789763 -1 8.2256856515821 652 494 262 510 524 362 701 321 300 283 595 512 M17850 GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 28/77 Gene Ontology MF GO:0004712 0.0625240373357473 0.0813608406632073 360 505.909090909091 495 0.00585227752568192 330 1.14272313240721 1.01136895275287 1 2.4442462059904 359 500 371 495 637 400 347 874 585 667 330 513 M18603 GO_SPECTRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECTRIN_BINDING.html Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. 14/40 Gene Ontology MF GO:0030507 0.00146166268211635 0.00249486023663645 690 503 495 0.000132966791231041 276 1.31565000401814 0.833118414947783 1 6.72279431041385 392 276 406 413 498 495 453 687 527 689 697 514 M18801 GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-specific protease. 6/13 Gene Ontology MF GO:1990381 0.0107995271074418 0.0159223797096898 225 481.636363636364 498 0.00108523723162929 183 0.521781820512482 -0.521781820512482 -1 1.84170337543336 266 509 820 498 653 183 221 295 756 874 223 515 M18913 GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY.html Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 11/62 Gene Ontology MF GO:0008227 2.55896734708848e-05 7.00669630750418e-05 285 464.909090909091 499 2.32636101148755e-06 57 1.72370124321613 1.72370124321613 1 14.0579620904301 281 693 321 730 767 499 529 57 332 514 391 516 M18231 GO_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 370/917 Gene Ontology MF GO:0016301 2.45546106209635e-07 3.76504029521441e-06 495 497.363636363636 500 2.23223757832272e-08 24 1.24362104489914 1.45098923876133 1 13.2424758007922 494 402 470 682 24 830 524 510 490 500 545 517 M18301 GO_FOLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_BINDING.html Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 7/12 Gene Ontology MF GO:0005542 1.4822324180704e-05 4.57601954572069e-05 660 462.272727272727 500 1.48224230472144e-06 170 1.97756700415751 -2.59816426782652 -1 16.8467105331059 659 376 707 500 278 640 510 212 170 388 645 518 M18642 GO_ORGANIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BINDING.html Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage. 104/287 Gene Ontology MF GO:0043177 0.000715712212078711 0.00126626006752387 395 486.181818181818 502 6.50859233044775e-05 69 1.92543294183222 -1.66512051050336 -1 10.9519488522552 394 809 69 450 490 588 552 637 502 317 540 519 M18352 GO_INTERLEUKIN_1_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the interleukin-1 receptor. 20/51 Gene Ontology MF GO:0005149 0.00177743855622132 0.00299495141341322 670 467.636363636364 503 0.000161716020231225 221 1.35833315248164 -1.98367465414003 -1 6.72932609173606 666 553 373 567 503 435 518 249 483 576 221 520 M18697 GO_CHEMOATTRACTANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOATTRACTANT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. 14/29 Gene Ontology MF GO:0042056 0.00236319806515997 0.00389631222212756 625 487.363636363636 504 0.000215067308325853 200 1.81577496344414 1.89633013535904 1 8.58824130578934 621 481 213 409 515 721 612 715 370 200 504 521 M18416 GO_RNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with an RNA polymerase molecule or complex. 21/48 Gene Ontology MF GO:0070063 0.0121352086309222 0.0177776941726886 410 470.454545454545 505 0.00110933345604413 252 0.971242847892293 -0.971242847892293 -1 3.33687382496234 408 527 505 633 573 283 252 351 622 674 347 522 M18464 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). 99/229 Gene Ontology MF GO:0016747 0.00168230691729596 0.00284507787483876 255 457.909090909091 505 0.000153054066453571 67 1.11801238081983 -1.05649478908378 -1 5.58768538816542 255 787 587 883 505 67 183 269 576 726 199 523 M18633 GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. 12/21 Gene Ontology MF GO:0052745 0.0883817209719584 0.106150369835773 370 523.909090909091 505 0.00837689213259701 291 0.825867915950773 -0.916650515732891 -1 1.57923777228318 367 635 423 590 857 291 505 344 812 547 392 524 M18280 GO_POLY_PURINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PURINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. 15/29 Gene Ontology MF GO:0070717 3.93926311821996e-05 9.90197286547095e-05 345 523.727272727273 506 3.58121241401371e-06 69 2.45545689968724 2.45545689968724 1 19.3018779775594 343 913 376 672 907 595 445 69 506 601 334 525 M17899 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 10/30 Gene Ontology MF GO:0016675 0.0695020788192352 0.0899323664046362 510 515.272727272727 507 0.0065272802411027 292 0.667179820668837 -0.667179820668837 -1 1.37010050013407 510 507 506 596 639 292 311 414 783 773 337 526 M18069 GO_MANNOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. 8/15 Gene Ontology MF GO:0015923 0.00137411344745929 0.00234978507743968 510 483.818181818182 508 0.000137496387214817 215 1.49301444484873 1.22541578923111 1 7.7053601716589 508 291 659 347 499 564 215 850 546 261 582 527 M17872 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. 11/30 Gene Ontology MF GO:0035255 0.0192387683925025 0.0273565176523992 650 550.636363636364 509 0.00176446349151103 263 0.932125096203368 -0.882226318451725 -1 2.85995545501893 647 451 385 374 853 476 862 263 665 509 572 528 M18248 GO_METALLOENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 31/124 Gene Ontology MF GO:0004222 3.88597343419011e-06 1.64750947440318e-05 895 544.272727272727 509 3.53270936200212e-07 196 1.5828629789602 -1.58356995803159 -1 14.8628579302956 895 351 356 757 196 718 792 488 509 335 590 529 M18396 GO_CARBON_CARBON_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_CARBON_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 20/54 Gene Ontology MF GO:0016830 0.000553361995222653 0.00100136517646078 300 502.363636363636 509 5.03182936718782e-05 296 1.17007882387784 -1.43526278019481 -1 6.8895933857628 530 412 296 740 463 509 784 303 615 577 297 530 M18267 GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY.html Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. 7/26 Gene Ontology MF GO:0004012 0.0765897756730953 0.0971897843024106 500 527.363636363636 511 0.00793650793650794 220 2.6412465055324 2.6412465055324 1 5.2492253989201 498 508 701 421 648 709 583 615 220 387 511 531 M18378 GO_PALMITOYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. 19/36 Gene Ontology MF GO:0016409 0.000667533868269637 0.00118787458183378 300 467.454545454545 511 6.0703318224768e-05 90 0.606762413303828 -0.606762413303828 -1 3.48434854425399 298 643 511 811 662 90 140 294 760 831 102 532 M18595 GO_RAGE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAGE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. 3/18 Gene Ontology MF GO:0050786 0.0189247436810735 0.0269934328474227 365 508.909090909091 511 0.00190878679260938 250 1.14058283762756 1.14058283762756 1 3.51254028743819 361 511 776 543 667 307 264 745 736 438 250 533 M19155 GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. 25/52 Gene Ontology MF GO:0019205 0.00214927269759826 0.00356275834556829 390 539.636363636364 512 0.000195579571724856 295 0.699316938211735 -0.731368208061475 -1 3.36098326111862 295 631 537 713 512 387 386 353 810 910 402 534 M18054 GO_NUCLEOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_BINDING.html Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. 35/80 Gene Ontology MF GO:0031491 0.00767537035430912 0.0115759684032203 230 482.545454545455 513 0.000700207249898135 154 2.11712996715667 2.49889312947203 1 8.04813328095943 348 569 230 513 916 628 584 226 154 657 483 535 M18262 GO_DAMAGED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DAMAGED_DNA_BINDING.html Interacting selectively and non-covalently with damaged DNA. 39/77 Gene Ontology MF GO:0003684 0.0433401800459019 0.0579548919218456 295 564.636363636364 513 0.00401984559047394 292 1.37148123597747 -0.715713620223799 -1 3.33020466937401 292 825 492 767 626 379 400 837 339 741 513 536 M18868 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. 5/29 Gene Ontology MF GO:0015347 0.0359035394610679 0.0489351945247148 515 515.818181818182 513 0.00364971619388447 278 1.36743551445372 -1.37558340851903 -1 3.51760171436952 513 384 833 523 621 510 278 354 752 301 605 537 M18495 GO_GLYCOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BINDING.html Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. 13/28 Gene Ontology MF GO:0051861 0.0300814491205799 0.0416791162514059 390 475.636363636364 515 0.00277280131779838 150 1.78984056864599 -2.80495818778103 -1 4.84911043515562 387 515 150 321 609 424 271 817 564 572 602 538 M18888 GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. 19/27 Gene Ontology MF GO:0003887 0.0837794594341775 0.101186047165595 205 535.181818181818 515 0.00792282749734231 203 0.825698217194658 -0.825698217194658 -1 1.61263005071446 203 795 515 778 686 356 373 339 745 714 383 539 M18035 GO_GUANYLATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYLATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + GMP = ADP + GDP. 7/16 Gene Ontology MF GO:0004385 0.00358343973589865 0.00572354957817145 180 457.909090909091 516 0.000358923135252025 176 0.68981701920642 -0.68981701920642 -1 3.03652808633441 237 637 645 516 595 249 176 222 794 790 176 540 M18402 GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 21/46 Gene Ontology MF GO:0008138 4.15331503677705e-06 1.70582581867629e-05 850 531.181818181818 516 3.77574807065327e-07 202 1.18133819900474 -1.35134556939213 -1 11.0575634963355 846 299 344 416 202 898 516 709 580 249 784 541 M18808 GO_POTASSIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_BINDING.html Interacting selectively and non-covalently with potassium (K+) ions. 9/25 Gene Ontology MF GO:0030955 0.000106794762275963 0.000232822704487881 865 530.181818181818 516 1.06799894927684e-05 156 1.85042753776242 -2.28976312783162 -1 13.1970679250663 862 325 823 156 389 885 532 516 219 462 663 542 M18593 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 47/117 Gene Ontology MF GO:0001191 0.000201707590996944 0.000405176820343205 520 566.545454545455 517 1.83387351805261e-05 333 1.68207945071441 1.48956499485299 1 11.201878291123 517 737 333 735 414 829 651 456 463 431 666 543 M18648 GO_CARBON_SULFUR_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_SULFUR_LYASE_ACTIVITY.html Catalysis of the elimination of hydrogen sulfide or substituted H2S. 8/13 Gene Ontology MF GO:0016846 0.000216283119258715 0.000430693657398306 310 477.636363636364 517 2.16304172417073e-05 121 0.985442999501796 -0.985442999501796 -1 6.51128759886822 309 534 790 542 508 375 517 121 741 610 207 544 M19110 GO_NUCLEOTIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. 11/28 Gene Ontology MF GO:0019201 0.00860902469987233 0.0128785410144432 235 487.363636363636 517 0.000785718109255681 186 0.68981701920642 -0.68981701920642 -1 2.55958368083157 235 757 517 639 564 262 186 284 804 902 211 545 M18375 GO_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOXYGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. 39/89 Gene Ontology MF GO:0051213 4.13441883230412e-05 0.000102987147973813 895 510.272727272727 518 3.7586332106435e-06 236 1.91737074155342 -1.95181133159695 -1 15.0078667252526 893 604 236 518 341 685 691 248 275 310 812 546 M18926 GO_INORGANIC_ANION_EXCHANGER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_EXCHANGER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). 3/24 Gene Ontology MF GO:0005452 0.480048871620753 0.519296900545448 520 549.909090909091 518 0.0633092047219835 344 1.10464210982906 1.10464210982906 1 0.617128239632504 344 519 853 436 720 518 352 501 801 440 565 547 M19186 GO_PHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 36/92 Gene Ontology MF GO:0019208 3.80655159666736e-05 9.7320403856916e-05 575 464.818181818182 518 3.46056132831769e-06 69 1.43670452934666 -1.02110370599452 -1 11.314863293524 662 308 370 212 331 890 572 573 69 518 608 548 M18943 GO_METHYL_CPG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYL_CPG_BINDING.html Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. 10/19 Gene Ontology MF GO:0008327 0.0190315950844697 0.0271038196249414 325 568.454545454545 519 0.00174529582893404 262 0.821057888859214 -0.821057888859214 -1 2.52567408288157 325 819 519 734 896 335 350 262 757 885 371 549 M18458 GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. 5/19 Gene Ontology MF GO:0005229 0.000374136077105168 0.000696771641572378 850 578.454545454545 520 3.74199082046767e-05 224 1.93412409573787 -2.72870663865022 -1 11.9864194435312 815 459 745 520 446 850 915 224 243 300 846 550 M17922 GO_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. 21/35 Gene Ontology MF GO:0034061 0.0899727320592865 0.10792035657698 350 559.818181818182 524 0.0085343480211103 228 0.825698217194658 -0.825698217194658 -1 1.56727197690227 228 870 524 779 747 349 414 347 773 721 406 551 M18133 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY.html Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. 8/13 Gene Ontology MF GO:0034595 0.0934615816029345 0.111959186295182 340 540.818181818182 526 0.00976420442650637 337 1.03228298181716 -1.03228298181716 -1 1.92705888622372 337 652 669 608 819 345 526 350 789 419 435 552 M18040 GO_S_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. 17/29 Gene Ontology MF GO:0016417 0.0313253252593121 0.043207345185258 355 536.818181818182 528 0.00288913262245856 137 0.321076871640942 -0.359800535967427 -1 0.860017302433786 352 796 528 885 766 193 137 348 836 792 272 553 M18110 GO_RHO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GTPASE_BINDING.html Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. 51/106 Gene Ontology MF GO:0017048 0.000105562604940661 0.000231549767349191 485 548.272727272727 528 9.59706095378719e-06 384 1.24825801217876 1.33182654585456 1 8.90828832256608 484 562 439 617 384 744 528 524 579 471 699 554 M18832 GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 14/25 Gene Ontology MF GO:0005086 0.000471429535509728 0.000869168682703306 455 533.909090909091 528 4.28664169679793e-05 251 1.32690512578787 -1.69680488176869 -1 7.9731775054112 790 528 454 419 451 674 251 674 327 691 614 555 M18816 GO_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a growth factor receptor. 75/186 Gene Ontology MF GO:0070851 6.24075100500773e-06 2.27836941452663e-05 900 535.909090909091 529 5.67342609840694e-07 229 1.54640074241317 1.13532308351216 1 14.0930615285847 898 536 241 650 229 629 876 529 464 358 485 556 M18136 GO_GLUCOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. 5/12 Gene Ontology MF GO:0015926 0.147859119791321 0.171972680414685 670 572.454545454545 531 0.0158730158730159 437 1.1231894092528 -1.1231894092528 -1 1.68576291691753 516 696 670 603 714 437 531 443 670 524 493 557 M18031 GO_ESTROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an estrogen receptor. 18/56 Gene Ontology MF GO:0030331 0.00484615143891789 0.00760829236144105 375 474.636363636364 532 0.000441532687269581 316 1.15636927625475 -1.23671529676043 -1 4.8096295791819 375 589 372 370 540 316 587 543 681 532 316 558 M18955 GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. 8/19 Gene Ontology MF GO:0015166 0.0165167738156145 0.0237058220130505 535 506.272727272727 532 0.00166408352757368 265 3.16445150237229 2.97328159107691 1 10.095632969431 532 334 861 312 588 610 295 773 452 265 547 559 M18344 GO_NUCLEOTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDASE_ACTIVITY.html Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. 7/15 Gene Ontology MF GO:0008252 0.00259656229426944 0.00425060019702471 400 532.363636363636 533 0.000259960125408455 195 1.95743070108192 -0.431271265300111 -1 9.11300548420478 400 830 720 728 533 596 530 195 257 591 476 560 M18142 GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 12/30 Gene Ontology MF GO:0016891 0.302507447061609 0.336525817771077 780 593.090909090909 534 0.0322207081718172 433 0.817827137870305 -0.817827137870305 -1 0.759361757565713 438 777 534 610 723 433 496 486 777 804 446 561 M18814 GO_1_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 10/24 Gene Ontology MF GO:0005545 0.00416212962782688 0.00656802617084172 685 579.818181818182 534 0.00037909316225773 231 1.7672728687454 -1.67697289518588 -1 7.57205602298403 683 388 231 328 534 915 761 907 290 492 849 562 M18515 GO_ELECTRON_CARRIER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_CARRIER_ACTIVITY.html Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 68/160 Gene Ontology MF GO:0009055 0.0839184282471183 0.101186047165595 865 610.181818181818 535 0.00793650793650794 275 1.72315224372782 -1.55204160259991 -1 3.36540290238108 656 863 416 828 905 275 409 863 520 535 442 563 M17877 GO_LONG_CHAIN_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 12/26 Gene Ontology MF GO:0036041 0.0272422426283509 0.0380316589045262 605 469 537 0.00250777684859992 169 2.54325138476412 -2.54325138476412 -1 7.08885672640035 595 266 169 357 604 603 685 386 560 537 397 564 M17959 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. 57/142 Gene Ontology MF GO:0016616 6.07151553980053e-05 0.000142859189171777 545 464.090909090909 537 5.51971191521246e-06 290 1.29004598295461 -1.30268113216458 -1 9.73766666377629 541 552 387 628 359 290 621 537 549 332 309 565 M18191 GO_CATION_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). 8/28 Gene Ontology MF GO:0015491 0.00393306325473435 0.0062386520592338 540 554.727272727273 537 0.000394004168782756 420 2.16235000280773 -1.82123018170123 -1 9.35965208541653 624 598 684 546 537 488 475 671 523 420 536 566 M19082 GO_MONOSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 36/85 Gene Ontology MF GO:0048029 0.0839184282471183 0.101186047165595 625 589.727272727273 537 0.00793650793650794 250 1.63710428925886 -1.31242230291365 -1 3.19734691948326 622 537 250 526 877 700 483 806 465 433 788 567 M17932 GO_NARROW_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NARROW_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. 6/17 Gene Ontology MF GO:0022842 1.948188408275e-06 1.06055226959349e-05 915 447.818181818182 538 1.94819011622423e-07 32 2.00920780316908 -1.71411418455206 -1 19.620699710999 915 121 622 32 151 633 538 918 48 176 772 568 M18189 GO_CLATHRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_BINDING.html Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. 29/71 Gene Ontology MF GO:0030276 2.7150163329321e-05 7.3681859182818e-05 540 556.363636363636 538 2.4682271268021e-06 233 1.20203293484534 -1.15454361950161 -1 9.75184701871239 802 281 323 538 315 714 871 827 537 233 679 569 M18019 GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 12/21 Gene Ontology MF GO:0030676 0.00431663084022513 0.00680017187158753 540 588.272727272727 539 0.000393193078356548 86 0.951420467605931 -0.929720281359942 -1 4.04828056005816 842 86 400 333 536 904 623 811 532 539 865 570 M18281 GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within. 4/13 Gene Ontology MF GO:0044213 0.000105959187015228 0.000231549767349191 730 551.363636363636 539 1.05964239661492e-05 104 2.34241681035133 -2.34241681035133 -1 16.7168359586228 729 539 704 412 712 728 917 104 211 478 531 571 M19032 GO_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. 50/110 Gene Ontology MF GO:0004540 0.0590216438438675 0.0773503024734446 310 560.727272727273 539 0.00551520244265797 307 1.29374701491095 -1.21748011320717 -1 2.82303755988649 307 892 539 854 757 347 431 318 587 720 416 572 M19210 GO_HEXOSAMINIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSAMINIDASE_ACTIVITY.html Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. 9/18 Gene Ontology MF GO:0015929 0.000105624687714338 0.000231549767349191 920 562.727272727273 539 1.05629708508805e-05 268 1.09943326733818 -0.724550607604034 -1 7.84618919083811 578 268 917 539 388 405 471 920 645 637 422 573 M18223 GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. 16/32 Gene Ontology MF GO:0015036 0.0613657234874079 0.079966665167727 845 623.818181818182 542 0.00574067332057009 323 0.918537239679941 -0.918537239679941 -1 1.9782556181613 536 844 457 797 903 542 525 323 843 703 389 574 M17897 GO_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. 52/152 Gene Ontology MF GO:0016597 0.0003398653128847 0.000643366435913423 710 527.181818181818 543 3.0901620734105e-05 117 2.05450063090735 -1.98251046550773 -1 12.8721113405017 543 710 117 407 441 737 735 706 442 278 683 575 M18339 GO_EXORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXORIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. 21/34 Gene Ontology MF GO:0004532 0.0833548735206944 0.101186047165595 245 550.727272727273 543 0.00788104187582553 239 0.82183161990898 -0.82183161990898 -1 1.60507839174331 245 897 543 831 705 239 281 399 814 722 382 576 M18128 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 15/37 Gene Ontology MF GO:0016893 0.0944802427652734 0.112885484862405 425 584.090909090909 544 0.00898180071062124 389 0.67747477300807 -0.67747477300807 -1 1.2599462283009 422 771 544 721 649 389 444 447 796 803 439 577 M19149 GO_MONOCARBOXYLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BINDING.html Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). 32/99 Gene Ontology MF GO:0033293 0.0318707931322454 0.0437897181223955 390 513 544 0.00294018937429441 157 2.38394045319171 -2.02082726540269 -1 6.35826920857166 388 839 157 469 614 565 544 553 460 558 496 578 M18003 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 49/105 Gene Ontology MF GO:0016651 0.00504330220525875 0.00785082576791548 85 463.181818181818 545 0.000459536433032917 85 1.07637031262136 -0.99217431572013 -1 4.44809721747284 85 893 567 876 545 94 100 231 754 740 210 579 M18577 GO_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BINDING.html Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. 29/74 Gene Ontology MF GO:0051287 1.14545923357813e-05 3.6846940380835e-05 605 523.181818181818 545 1.04133199782483e-06 260 1.10107268490045 -1.15752945093739 -1 9.58330598898177 548 455 491 545 260 464 680 605 601 672 434 580 M18874 GO_RAC_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GTPASE_BINDING.html Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. 29/56 Gene Ontology MF GO:0048365 6.4938954643322e-07 5.63621115772229e-06 890 546 545 5.90354307380183e-08 71 1.26468495921347 -1.15425133460252 -1 13.0317572031532 886 265 393 386 71 840 882 607 545 403 728 581 M19160 GO_EXODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. 7/19 Gene Ontology MF GO:0004529 0.0369993586687019 0.0502056194324568 265 521.454545454545 545 0.00376302214121281 196 0.824202640966605 -0.824202640966605 -1 2.10217530999621 265 545 903 568 675 196 239 436 690 911 308 582 M17903 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. 6/30 Gene Ontology MF GO:0031434 2.45944187479075e-05 6.79485442885133e-05 625 519.636363636364 546 2.45946909505926e-06 197 0.762326410379193 -0.726974651600212 -1 6.23724637951198 623 197 616 276 314 487 858 546 727 774 298 583 M18206 GO_CATECHOLAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BINDING.html Interacting selectively and non-covalently with catecholamine. 4/17 Gene Ontology MF GO:1901338 0.00922799032324217 0.0137152683317977 385 516.363636363636 546 0.000926653590271529 243 1.0818214294583 1.0818214294583 1 3.95606844195667 381 546 687 606 692 624 395 243 578 476 452 584 M18585 GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). 20/44 Gene Ontology MF GO:0016776 0.0257954932744695 0.0361215430936255 160 496.545454545455 546 0.00237300102018446 159 0.669209175637574 -0.669209175637574 -1 1.89470023136142 159 690 546 680 722 226 223 306 793 854 263 585 M18384 GO_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any phosphatase. 97/251 Gene Ontology MF GO:0019902 1.31631517870648e-05 4.17589642899988e-05 845 490.545454545455 547 1.19665732237847e-06 120 1.68217061705375 -1.34213241284664 -1 14.4614822471158 844 319 182 120 266 547 807 591 255 580 885 586 M18940 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 201/490 Gene Ontology MF GO:0004674 1.01339747932547e-06 7.11845079997341e-06 525 522 547 9.21270860120304e-08 94 1.15956062432258 1.24995618144914 1 11.7177026959672 525 296 501 691 94 748 556 661 547 468 655 587 M19165 GO_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_ACTIVITY.html Catalysis of the hydrolysis of a glycerophospholipid. 31/102 Gene Ontology MF GO:0004620 1.63153466844278e-05 4.95383463685597e-05 620 528.363636363636 547 1.48322433467117e-06 160 1.81854464888724 -1.89714337099367 -1 15.3690146556521 619 547 160 490 279 776 618 903 334 268 818 588 M18466 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. 17/46 Gene Ontology MF GO:0043027 0.000192561721316864 0.000389355568376956 895 555.363636363636 548 1.75071434486782e-05 203 2.3392768022608 -2.1449276369515 -1 15.6579490161045 892 548 255 203 411 893 888 786 203 371 659 589 M18772 GO_RETINOIC_ACID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. 16/135 Gene Ontology MF GO:0042974 0.0166262020119323 0.0238257100482519 335 553.818181818182 549 0.00152301799885149 332 1.05044736071832 1.05044736071832 1 3.34675202058181 332 692 467 549 586 418 432 751 790 616 459 590 M18104 GO_HYDRO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDRO_LYASE_ACTIVITY.html Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. 34/52 Gene Ontology MF GO:0016836 5.6187167128895e-07 5.19029108191918e-06 685 444.363636363636 550 5.10792558898998e-08 14 1.05812424155762 -1.05660887696218 -1 10.9776378637457 684 14 299 346 65 537 677 550 575 581 560 591 M18580 GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 44/102 Gene Ontology MF GO:0004725 4.03934806320943e-06 1.68153856025008e-05 815 540.818181818182 550 3.67214134522127e-07 199 1.21444075460615 -1.18500160731232 -1 11.3822577351953 812 404 345 583 199 758 705 534 550 236 823 592 M17991 GO_FATTY_ACYL_COA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_BINDING.html Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. 19/35 Gene Ontology MF GO:0000062 0.0868599372238887 0.104459009471866 480 584.181818181818 552 0.00822652096903333 245 1.21750281449381 1.21750281449381 1 2.34480058619145 480 898 552 807 800 245 272 400 852 713 407 593 M18741 GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the directed movement of water (H2O) from one side of a membrane to the other. 7/14 Gene Ontology MF GO:0005372 0.00533788067117382 0.00826742460855204 850 605.545454545455 552 0.000535074602239167 315 3.56895025600191 -3.54679132496305 -1 14.5913529806283 849 401 805 315 552 844 522 692 498 390 793 594 M18507 GO_PHOSPHOTYROSINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTYROSINE_BINDING.html Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. 7/23 Gene Ontology MF GO:0001784 0.00569354737558739 0.00873010597590066 755 516.818181818182 554 0.000570818761141737 264 1.30559396322672 -1.8565487527271 -1 5.2771976215576 587 478 755 264 554 508 751 600 291 594 303 595 M18666 GO_DEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. 35/77 Gene Ontology MF GO:0004536 0.009880048362297 0.0146410624411374 755 505.363636363636 555 0.000902245451835045 242 0.705107830814528 -0.726151039738547 -1 2.5392125396302 262 629 555 751 568 242 370 345 721 752 364 596 M18417 GO_CARBOHYDRATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. 7/20 Gene Ontology MF GO:0019200 0.00342887185166371 0.00548619496266194 595 480.272727272727 556 0.000343417409271477 174 0.817602703171385 -0.817602703171385 -1 3.62855549307095 239 556 736 605 594 233 413 379 761 593 174 597 M18896 GO_K63_LINKED_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_K63_LINKED_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. 9/19 Gene Ontology MF GO:0070530 0.00381260105679938 0.00607901728293836 620 560.181818181818 557 0.000381915806226795 298 0.977742839517968 -0.930803565006316 -1 4.25373123470377 616 324 842 420 535 557 834 298 602 633 501 598 M18915 GO_IRON_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_BINDING.html Interacting selectively and non-covalently with iron (Fe) ions. 55/229 Gene Ontology MF GO:0005506 1.44092757796951e-05 4.49711936433271e-05 535 515.181818181818 557 1.30994274150667e-06 113 1.80389812484583 1.83863111955518 1 15.3939899714237 535 568 113 612 272 735 557 853 484 247 691 599 M18952 GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. 28/83 Gene Ontology MF GO:0070491 0.0557096446721704 0.0732183901405668 380 566 557 0.0051974987758652 317 0.826173590158981 -0.620680399468506 -1 1.84143104268062 739 378 514 557 633 317 380 783 753 743 429 600 M19142 GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 23/47 Gene Ontology MF GO:0016796 0.0318903381978315 0.0437897181223955 255 558.090909090909 557 0.0029420193120647 178 0.7177242901481 -0.7177242901481 -1 1.91426094040497 252 869 557 815 643 178 242 491 829 908 355 601 M19174 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. 4/12 Gene Ontology MF GO:0016861 0.0289894929893746 0.0402875129157472 365 553.818181818182 558 0.00293747614287759 231 0.58371703941372 -0.58371703941372 -1 1.59833012255498 365 231 906 434 613 410 558 586 594 913 482 602 M18651 GO_LIPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 14/21 Gene Ontology MF GO:0060229 0.00276745706928901 0.00451429167330831 805 591.636363636364 559 0.000251904044887896 404 1.61608484034119 1.95952492470059 1 7.44090905961905 804 529 404 443 519 754 598 417 559 584 897 603 M17853 GO_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently with a polymer of ubiqutin. 25/46 Gene Ontology MF GO:0031593 0.000353166106619023 0.000661736900385949 225 443.090909090909 560 3.21111648305439e-05 49 0.857744817050334 -0.8042756741776 -1 5.35346056513644 223 642 560 731 669 49 203 261 718 736 82 604 M18202 GO_AMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. 24/43 Gene Ontology MF GO:0004177 2.8621471689232e-06 1.30355217594522e-05 565 565 561 2.60195535683156e-07 177 1.65250325789216 1.45067185080868 1 15.8466868233237 561 411 355 616 177 879 891 784 470 410 661 605 M18244 GO_RNA_CAP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING.html Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. 11/18 Gene Ontology MF GO:0000339 0.109876874125161 0.1300987441379 415 593.363636363636 561 0.0105256213144464 201 0.228132111588543 -0.294002353961449 -1 0.39666981146343 412 773 561 781 822 306 201 556 862 813 440 606 M18307 GO_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids. 100/224 Gene Ontology MF GO:0004518 0.000836435879415789 0.00147135948195512 345 561.818181818182 561 7.60685509221629e-05 342 0.994125949409124 -0.964873758068164 -1 5.52739849327797 342 709 580 891 482 351 561 452 596 754 462 607 M18904 GO_TETRAPYRROLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BINDING.html Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. 38/185 Gene Ontology MF GO:0046906 0.00774090118406295 0.0116556940905694 540 601.181818181818 562 0.000706206653024917 187 1.51001615495166 1.51938515750974 1 5.73139312022951 537 526 187 771 562 749 546 841 607 553 734 608 M19013 GO_ENDORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. 26/63 Gene Ontology MF GO:0004521 0.0417046852894142 0.0560121320675344 415 592.363636363636 563 0.00386517335097168 296 1.12505726913343 -1.12505726913343 -1 2.76454764233526 414 768 516 820 868 462 563 296 739 707 363 609 M18298 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 76/168 Gene Ontology MF GO:0001076 1.88111457353576e-05 5.49404891318381e-05 565 558.636363636364 564 1.71011878021598e-06 289 1.41484147850709 1.35216540714308 1 11.8323590112294 564 734 392 698 289 863 634 448 440 366 717 610 M18313 GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. 6/21 Gene Ontology MF GO:0004303 0.0218625414430192 0.0310394106907063 400 531.454545454545 565 0.00220806544421843 200 0.611995773108909 -0.611995773108909 -1 1.81183090627326 397 565 712 623 836 200 250 270 847 821 325 611 M18421 GO_ADENOSINE_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOSINE_DEAMINASE_ACTIVITY.html Catalysis of the reaction: adenosine + H2O = inosine + NH3. 6/10 Gene Ontology MF GO:0004000 0.00327769005345375 0.00527180917688366 535 638.818181818182 565 0.000328253457652135 486 1.18816817833294 -0.82915100755709 -1 5.31351997562529 539 524 737 692 532 486 821 894 703 565 534 612 M18901 GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING.html Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. 8/17 Gene Ontology MF GO:0043560 0.0018031383921737 0.00302716664379526 520 547.818181818182 565 0.000180460315381775 182 1.30875681619819 -1.30875681619819 -1 6.47178165290909 520 636 844 459 587 439 794 182 565 612 388 613 M18096 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. 6/20 Gene Ontology MF GO:0030169 0.801223401056712 0.836691860354342 605 562.363636363636 566 0.149182281623086 241 1.03034063120141 1.03034063120141 1 0.156623820417481 241 558 664 486 769 566 495 601 866 336 604 614 M18164 GO_TRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_BINDING.html Interacting selectively and non-covalently with transfer RNA. 17/47 Gene Ontology MF GO:0000049 0.135914116690366 0.159694747579996 275 579.727272727273 566 0.0131924891265007 272 0.614384147243524 -0.614384147243524 -1 0.960910377605806 272 817 566 850 660 326 374 521 786 806 399 615 M17898 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 30/65 Gene Ontology MF GO:0016627 0.128407773349842 0.151261397543989 570 604.818181818182 567 0.0124162376097315 272 0.992928485582983 -0.814221486124961 -1 1.59889069821911 567 854 551 869 780 272 417 431 781 675 456 616 M18875 GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. 6/13 Gene Ontology MF GO:0008484 0.0109534403651909 0.0160977078849451 270 503.909090909091 568 0.00110078079387914 22 3.40014050976233 3.40014050976233 1 11.9695356362272 464 620 836 272 572 781 872 268 22 568 268 617 M18323 GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. 11/19 Gene Ontology MF GO:0010485 0.0427750349425996 0.0572824339842673 220 520.363636363636 569 0.00396637144594772 199 0.517174830436356 -0.517174830436356 -1 1.26094005450408 219 717 569 687 738 199 228 425 798 825 319 618 M18861 GO_PHOSPHATIDIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_BINDING.html Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 6/19 Gene Ontology MF GO:0070300 0.00988271714776771 0.0146410624411374 375 600.363636363636 570 0.00099269448677568 337 0.477276584026305 0.477276584026305 1 1.71875366025349 374 760 831 560 570 403 337 657 805 879 428 619 M19222 GO_SNORNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_BINDING.html Interacting selectively and non-covalently with small nucleolar RNA. 18/31 Gene Ontology MF GO:0030515 0.157789214159266 0.183059365733322 715 605.090909090909 570 0.0154901340665174 385 0.945854730970701 -0.825626961674577 -1 1.36922646458306 421 739 521 816 782 446 553 385 712 711 570 620 M18430 GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. 13/28 Gene Ontology MF GO:0003950 0.000291344841469001 0.00055957673100518 500 594.545454545455 571 2.648940284252e-05 336 1.34214959716038 1.76488086425431 1 8.56866577130127 777 336 455 496 433 725 795 578 496 571 878 621 M18472 GO_ALPHA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. 16/35 Gene Ontology MF GO:0043014 0.0255253254536637 0.0357977125264795 575 553.090909090909 571 0.00234785297364272 325 2.30429135094652 2.74688468994183 1 6.5417228877822 571 632 338 581 602 803 782 484 325 497 469 622 M18905 GO_3_5_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. 30/52 Gene Ontology MF GO:0008408 0.0128292973379891 0.0187646320364864 200 519.454545454545 573 0.0011731570832433 132 0.702534654581087 -0.702534654581087 -1 2.38131886086627 196 879 573 784 596 132 194 343 835 882 300 623 M18916 GO_STEROID_HYDROXYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HYDROXYLASE_ACTIVITY.html Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. 7/72 Gene Ontology MF GO:0008395 0.0437043380637356 0.0582724507516475 505 543.090909090909 575 0.00445884409998155 225 1.48493693140327 1.68309632916755 1 3.59877761303381 503 335 849 563 629 583 378 575 698 225 636 624 M18774 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. 6/15 Gene Ontology MF GO:0016307 0.0219059355220366 0.0310530981206066 385 595.727272727273 576 0.00221249213558928 260 0.649028495819349 -0.649028495819349 -1 1.92122339013159 384 505 815 718 860 301 426 576 838 870 260 625 M17996 GO_RNA_POLYMERASE_III_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_III_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 9/21 Gene Ontology MF GO:0001056 0.00197067099889917 0.00329639512543133 580 409.272727272727 577 0.000197242077806247 113 0.91343148314624 -0.91343148314624 -1 4.45055196438348 167 577 634 595 657 113 142 187 577 628 225 626 M18734 GO_ENDONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. 61/143 Gene Ontology MF GO:0004519 0.0551199315071057 0.0725469770908973 565 614.545454545455 578 0.00514103678297604 314 1.01359936711371 -1.07418171785445 -1 2.26713909120893 565 578 527 865 642 561 856 314 583 730 539 627 M19144 GO_RNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. 22/44 Gene Ontology MF GO:0034062 0.0652071738773288 0.0844938027706233 185 539.363636363636 578 0.00611128155884828 185 0.832044496001853 -0.832044496001853 -1 1.7529120870113 185 801 578 829 772 221 361 357 732 728 369 628 M17926 GO_UBIQUITIN_LIKE_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_BINDING.html Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. 76/151 Gene Ontology MF GO:0032182 0.00767407445072292 0.0115759684032203 735 570.181818181818 579 0.000700088612455791 191 0.972106275404818 -0.869569889284203 -1 3.69539937499876 526 735 579 830 561 191 464 588 733 727 338 629 M17891 GO_BETA_2_MICROGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_2_MICROGLOBULIN_BINDING.html Interacting selectively and non-covalently with beta-2-microglobulin. 16/41 Gene Ontology MF GO:0030881 0.0839184282471183 0.101186047165595 495 588.909090909091 581 0.00793650793650794 341 1.82162631708836 -1.39321412789437 -1 3.5577277204513 492 705 341 530 734 511 615 854 581 496 619 630 M17983 GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. 2/28 Gene Ontology MF GO:0022835 0.0517394407823611 0.0684896194529097 730 603.9 581 0.00588549698257709 325 0.597600669636257 -0.597600669636257 -1 1.36598840057537 505 729 629 NA 730 480 533 325 802 785 521 631 M18885 GO_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_BINDING.html Interacting selectively and non-covalently with any enzyme. 957/2452 Gene Ontology MF GO:0019899 4.76492323956177e-07 4.87603297698976e-06 585 564.545454545455 581 4.76492426126428e-08 57 1.40399211279301 1.6146520542039 1 14.6406475588274 581 254 839 823 57 731 655 558 432 516 764 632 M17963 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. 14/28 Gene Ontology MF GO:0052866 0.214690951112567 0.243846512374768 420 613.363636363636 582 0.0217311239521864 395 1.03228298181716 -1.03228298181716 -1 1.24199438224264 416 912 529 766 801 395 654 416 806 582 470 633 M19066 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. 33/67 Gene Ontology MF GO:0016655 0.06035576242655 0.0787621296913844 135 510.090909090909 582 0.00564346512206283 134 0.989081760643701 -0.989081760643701 -1 2.14298608917269 134 826 582 790 685 215 217 334 730 750 348 634 M19169 GO_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. 43/97 Gene Ontology MF GO:0008080 0.0839184282471183 0.101186047165595 315 549.727272727273 583 0.00793650793650794 282 0.949818059174918 -1.03060744062034 -1 1.85504234476428 315 824 583 783 741 282 344 432 639 729 375 635 M18820 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. 19/45 Gene Ontology MF GO:0015932 0.00301310122984671 0.00490628872824596 825 589.272727272727 584 0.00027429417069531 206 0.850208137996264 -0.67529576188881 -1 3.85423879051545 823 206 460 373 523 806 650 584 683 557 817 636 M17974 GO_PROTEIN_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any protein phosphatase. 79/199 Gene Ontology MF GO:0019903 3.72673201285999e-06 1.60864972870384e-05 855 519.636363636364 585 3.3879439325853e-07 174 1.79596998868193 -1.41834666349379 -1 16.9004510613507 854 473 183 174 193 620 854 628 266 585 886 637 M18692 GO_N_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. 48/116 Gene Ontology MF GO:0016410 0.0759181128297463 0.0971897843024106 360 538 585 0.00715199179486938 235 0.904011819091348 -0.932032020724494 -1 1.79663716522535 357 837 585 796 753 235 313 346 638 716 342 638 M19024 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. 25/65 Gene Ontology MF GO:0016860 0.298735036746822 0.332731517926242 695 606 586 0.0317460317460317 450 0.931197746285691 -1.06087992576476 -1 0.873629734518079 586 570 503 786 695 475 694 450 709 699 499 639 M19212 GO_MRNA_3_UTR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_UTR_BINDING.html Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. 25/64 Gene Ontology MF GO:0003730 0.0839184282471183 0.101186047165595 590 569.727272727273 586 0.00793650793650794 329 1.20522903403715 1.20064607292191 1 2.35387282467821 570 608 433 620 764 531 586 549 589 329 688 640 M18444 GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 2/15 Gene Ontology MF GO:0005247 0.0958228942123831 0.114341196725541 590 605.2 587.5 0.0111298249874951 206 0.254795131713319 -0.136074829109231 -1 0.471076527532555 590 585 741 NA 708 472 206 506 857 841 546 641 M18620 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. 24/54 Gene Ontology MF GO:0004520 0.0366275501669391 0.0497745142593559 620 574.181818181818 588 0.00338654196062056 381 0.671080742199649 -0.686930399247323 -1 1.71656331377433 466 588 526 667 617 381 620 533 722 733 463 642 M18764 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES.html Catalysis of the transfer of a phosphate group from one position to another within a single molecule. 6/10 Gene Ontology MF GO:0016868 0.0314969490004286 0.0433790315574766 695 570.181818181818 588 0.00319524888289221 157 2.27029121375704 2.27029121375704 1 6.07339099100384 694 441 810 466 678 834 750 287 157 567 588 643 M18880 GO_DRUG_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORTER_ACTIVITY.html Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 10/30 Gene Ontology MF GO:0090484 0.0839184282471183 0.101186047165595 795 589.818181818182 588 0.00793650793650794 126 3.09736970202823 -2.99609723536049 -1 6.04931871531689 793 574 269 588 839 876 346 670 126 493 914 644 M19020 GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. 51/118 Gene Ontology MF GO:0019783 0.0305787778136554 0.0422409543371816 825 573.090909090909 588 0.0028192968178102 177 0.890282177071692 -0.896779989676827 -1 2.40182606791384 366 823 588 856 821 177 379 434 822 763 275 645 M18453 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 46/107 Gene Ontology MF GO:0004197 6.73928988612171e-06 2.4125084417245e-05 915 556.090909090909 589 6.12664593706228e-07 212 1.93632324864311 -1.62332660986824 -1 17.5521650680369 913 836 212 656 234 589 760 567 304 405 641 646 M19098 GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS.html Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 28/44 Gene Ontology MF GO:0016875 0.156589314426861 0.181896678374636 205 595.363636363636 589 0.0153627044244739 204 0.526361781646576 -0.526361781646576 -1 0.764824592812325 204 814 589 855 762 289 390 480 848 901 417 647 M18785 GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. 73/147 Gene Ontology MF GO:0008757 0.298735036746822 0.332731517926242 825 648.909090909091 590 0.0317460317460317 382 0.837993847202232 -0.983832857392169 -1 0.786187827667596 550 822 581 886 825 382 590 563 717 768 454 648 M18225 GO_GDP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_BINDING.html Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. 42/79 Gene Ontology MF GO:0019003 0.0839184282471183 0.101186047165595 435 610.545454545455 591 0.00793650793650794 432 1.20515107279482 1.28148890456851 1 2.35372056245084 432 765 479 719 882 704 548 552 591 443 601 649 M18551 GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. 9/22 Gene Ontology MF GO:0004653 0.0018452808394069 0.00309227390210264 690 603.545454545455 591 0.000184681491016432 183 1.04384782560598 1.03848106298591 1 5.14287312718888 740 532 768 512 591 911 688 183 567 458 689 650 M18570 GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. 38/83 Gene Ontology MF GO:0004843 0.261777984457176 0.29478059449278 855 658.363636363636 591 0.0272146997885261 371 0.885431156435718 -0.89680977476733 -1 0.922112806090442 591 838 571 863 824 371 588 460 851 853 432 651 M18974 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/73 Gene Ontology MF GO:0016903 9.96153264230971e-05 0.000221903390579296 740 584 591 9.05634884186636e-06 320 1.79193086481003 -1.93578407753223 -1 12.8532604199096 736 700 320 585 381 591 665 781 556 368 741 652 M18150 GO_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to an acceptor molecule. 51/114 Gene Ontology MF GO:0016407 0.0749289420739352 0.0965470962297204 255 526.727272727273 592 0.00705542236319608 232 0.939310478721923 -1.00138117303328 -1 1.87210308237093 254 864 592 805 647 232 302 372 640 745 341 653 M18499 GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. 33/77 Gene Ontology MF GO:0000979 0.0150513348454888 0.0217381916135788 715 596.727272727273 592 0.00137775509212007 484 1.00173852782517 -0.772253970681801 -1 3.26987588104204 713 649 484 489 579 513 641 503 706 695 592 654 M18119 GO_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. 45/90 Gene Ontology MF GO:0008170 0.0988455252400937 0.117642798474626 480 609.363636363636 593 0.00941706886687748 255 0.595386185850892 -0.50616546084653 -1 1.08632701174411 477 794 593 889 811 255 366 520 800 802 396 655 M18345 GO_ION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ion A(out) + ion B(in) = ion A(in) + ion B(out) where ion A and ion B are different types of ion. 12/57 Gene Ontology MF GO:0099516 0.022917629292057 0.0324372599210652 735 590.363636363636 593 0.00210544594714561 302 1.9634192088317 2.03451372239693 1 5.73902144858188 731 706 302 673 593 563 753 644 569 376 584 656 M19077 GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. 28/59 Gene Ontology MF GO:0016278 0.198391671469123 0.226733338821854 595 649.818181818182 594 0.0199024743078551 313 0.61287747695946 -0.496537680561485 -1 0.775406014638643 593 840 576 862 851 313 363 594 844 898 414 657 M19195 GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 11/30 Gene Ontology MF GO:0017112 0.000994018236875324 0.00173200147334337 665 618.272727272727 594 9.04061495390588e-05 400 0.837625220665132 0.932540053560895 1 4.54077723771221 594 400 500 477 487 907 839 590 663 664 680 658 M18657 GO_NADH_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. 26/44 Gene Ontology MF GO:0003954 0.244594898699949 0.276107124912825 845 614.181818181818 595 0.0251777199003479 268 0.582845558623966 -0.582845558623966 -1 0.639510873286416 268 841 595 845 761 323 349 560 894 863 457 659 M18676 GO_VITAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BINDING.html Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 36/91 Gene Ontology MF GO:0019842 1.81061375501045e-06 1.02824978679606e-05 825 498.454545454545 595 1.6460138592351e-07 138 1.72900293403504 -1.78436683504248 -1 16.9299855538921 824 595 214 602 138 706 892 189 375 333 615 660 M19047 GO_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEAMINASE_ACTIVITY.html Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). 11/28 Gene Ontology MF GO:0019239 4.97974834668187e-06 1.90890353289472e-05 765 585.727272727273 595 4.52705419862491e-07 215 1.06075944983379 1.13796226392603 1 9.82719932154762 761 332 383 716 215 845 638 595 571 515 872 661 M18531 GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. 32/69 Gene Ontology MF GO:0034212 0.0344446176927526 0.0471563218412685 270 551.545454545455 596 0.00318145726776771 186 0.94112625638905 -0.94112625638905 -1 2.45067126514432 267 895 596 846 887 186 227 355 780 748 280 662 M17893 GO_HEAT_SHOCK_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAT_SHOCK_PROTEIN_BINDING.html Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. 58/119 Gene Ontology MF GO:0031072 0.232850105696956 0.263495814564821 405 650.090909090909 597 0.0238095238095238 369 0.889450431352014 1.00478410507987 1 1.01137675586047 404 834 572 870 914 558 369 597 694 760 579 663 M19228 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. 28/59 Gene Ontology MF GO:0042054 0.0943229408852034 0.112844090525861 350 608 598 0.00896615156478539 251 0.434894544427673 -0.434894544427673 -1 0.808939116871851 350 868 598 871 823 251 258 508 861 920 380 664 M18005 GO_CORE_PROMOTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. 95/242 Gene Ontology MF GO:0001047 0.00564929297955723 0.00869121996854959 445 601.727272727273 600 0.000514895631094637 274 1.54250030472142 -1.23087207312745 -1 6.24064145518911 756 746 274 600 548 442 833 832 443 604 541 665 M18172 GO_PROTEIN_C_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_C_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 126/295 Gene Ontology MF GO:0008022 4.88983182933926e-06 1.89018709369417e-05 680 588.636363636364 600 4.44531154341987e-07 214 1.21136453262206 1.28057274416183 1 11.2326268421826 679 368 465 566 214 600 832 838 513 694 706 666 M18187 GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. 6/18 Gene Ontology MF GO:0004550 0.305665553247074 0.339628392496749 350 587.272727272727 600 0.0358227695748274 349 0.298586394362133 -0.328207537735641 -1 0.274904603795412 349 600 683 654 698 364 402 528 855 808 519 667 M18995 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS.html Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). 105/227 Gene Ontology MF GO:0016741 0.0737162132294677 0.0952512867571774 340 593.909090909091 600 0.00693715571625773 230 0.876012049647196 -0.876655411694172 -1 1.75603728201595 338 810 600 888 900 230 420 499 673 770 405 668 M19204 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 448/1070 Gene Ontology MF GO:0016772 3.79878888847113e-07 4.49709854751353e-06 850 612 601 3.45344504037874e-08 38 1.20613275072517 -0.995065069583148 -1 12.660585299661 896 601 553 849 38 315 877 849 510 653 591 669 M18389 GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group (CH3-) to a protein. 43/84 Gene Ontology MF GO:0008276 0.0528613063675585 0.0698741406007957 435 598.909090909091 602 0.00492508097670378 217 0.567420708150758 -0.50616546084653 -1 1.2873216458348 435 865 602 887 845 217 289 478 824 834 312 670 M18447 GO_CHROMATIN_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DNA_BINDING.html Interacting selectively and non-covalently with DNA that is assembled into chromatin. 53/136 Gene Ontology MF GO:0031490 0.00013690061130671 0.000288872849546269 870 613.545454545455 602 1.24462846398784e-05 247 1.65868826682822 1.92991957289597 1 11.5245591731548 870 602 347 537 396 715 808 856 247 579 792 671 M18791 GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. 21/46 Gene Ontology MF GO:0018024 0.167905206485134 0.193689562296885 875 633.090909090909 602 0.016571064914825 287 0.434894544427673 -0.434894544427673 -1 0.608627708414341 472 842 577 875 869 311 287 602 864 871 394 672 M18243 GO_MANGANESE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_BINDING.html Interacting selectively and non-covalently with manganese (Mn) ions. 33/69 Gene Ontology MF GO:0030145 0.000113743317051478 0.000245642844336524 365 590.363636363636 604 1.03408361980144e-05 361 1.18703650484822 -1.20986106136168 -1 8.41158206699174 826 542 361 759 386 570 767 363 604 646 670 673 M18869 GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY.html Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. 5/14 Gene Ontology MF GO:0045125 0.0250599495515604 0.0353065139164404 665 635.454545454545 605 0.00253471183872089 436 1.49863107644468 -1.49863107644468 -1 4.27216245355326 661 436 834 552 605 573 582 788 776 527 656 674 M18214 GO_NEUROPEPTIDE_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_HORMONE_ACTIVITY.html The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. 8/29 Gene Ontology MF GO:0005184 0.00643960649283331 0.00977630028614957 445 588.727272727273 606 0.000645834379594261 430 2.32959747928114 2.32959747928114 1 9.19141193656488 442 612 690 684 558 506 430 810 701 606 437 675 M19209 GO_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY.html Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 210/431 Gene Ontology MF GO:0016874 2.88307935731448e-05 7.68821161950527e-05 900 478.090909090909 606 2.62101558226558e-06 18 0.953226343092863 -1.01040498279373 -1 7.6987773323997 169 849 606 896 899 18 188 192 635 769 38 676 M18422 GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME.html The action of a molecule that contributes to the structural integrity of the ribosome. 129/311 Gene Ontology MF GO:0003735 0.0155398139168904 0.0224085090964564 130 523.181818181818 607 0.001422788917413 129 0.679775806486761 -0.618417941379508 -1 2.20132376614889 129 808 607 864 763 139 153 469 751 771 301 677 M18728 GO_METALLOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 58/200 Gene Ontology MF GO:0008237 3.73351587134886e-05 9.64841180236222e-05 330 605.181818181818 607 3.39416293871362e-06 328 1.5811206170269 -1.39552468014556 -1 12.4638555751165 773 328 362 808 328 607 870 801 492 413 875 678 M19213 GO_SEMAPHORIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_ACTIVITY.html Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 3/11 Gene Ontology MF GO:0017154 0.495725531260169 0.534662941101238 920 661.818181818182 607 0.0661724164344007 356 0.841478148107057 1.18079972020767 1 0.449186577902603 469 561 918 607 758 586 356 593 827 918 687 679 M19207 GO_ACYL_COA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. 11/19 Gene Ontology MF GO:0003995 0.194518863406724 0.222860964301601 610 620.545454545455 608 0.0194729492447014 253 1.21750281449381 1.21750281449381 1 1.55825272016481 608 807 481 788 793 427 253 582 846 665 576 680 M17928 GO_RNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. 26/48 Gene Ontology MF GO:0008173 0.331607650118105 0.367565106155008 450 621 611 0.0359628501996743 366 0.650388808897222 -0.670213924761512 -1 0.554972395350118 450 767 549 826 711 366 611 492 809 776 474 681 M18612 GO_TRANSLATION_INITIATION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_BINDING.html Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. 15/32 Gene Ontology MF GO:0031369 0.113332514707406 0.134017883715699 615 645.272727272727 611 0.0108754520329017 471 0.813667323195685 -0.75946266630292 -1 1.39419370333748 611 633 542 599 654 471 575 771 779 856 607 682 M19183 GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. 24/53 Gene Ontology MF GO:0005547 0.0839184282471183 0.101186047165595 615 590.181818181818 612 0.00793650793650794 287 1.70742825605818 1.34372929455859 1 3.33469316361736 476 855 287 565 778 612 419 656 613 622 609 683 M17924 GO_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. 110/237 Gene Ontology MF GO:0042393 0.0839184282471183 0.101186047165595 455 618.545454545455 613 0.00793650793650794 396 1.20026006939702 -0.934700525862436 -1 2.34416818681976 453 890 535 847 699 396 465 613 631 749 526 684 M18126 GO_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 93/233 Gene Ontology MF GO:0019207 2.36447311488113e-06 1.17584608956251e-05 730 583.090909090909 615 2.14952332375207e-07 159 1.36704128863134 -1.27380606819098 -1 13.2294160469216 727 615 357 453 159 767 879 845 402 316 894 685 M18148 GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. 7/17 Gene Ontology MF GO:0017110 0.000510930367229691 0.000934936838113424 745 597.454545454545 615 5.11047877684661e-05 251 0.896525279097937 0.896525279097937 1 5.33133563030648 742 251 675 615 464 659 459 871 522 589 725 686 M17942 GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY.html Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 51/102 Gene Ontology MF GO:0070035 0.628032948079164 0.667965678881885 475 675.545454545455 616 0.0859815715741387 450 0.707991537080542 -0.707991537080542 -1 0.243567110171705 474 852 604 837 807 450 555 616 878 780 578 687 M18434 GO_BETA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. 28/46 Gene Ontology MF GO:0048487 0.0254210872131091 0.0357059545588708 670 635.181818181818 616 0.00233815185409521 456 1.519731120483 1.92876290783029 1 4.31773629332464 668 616 456 646 601 901 607 708 503 668 613 688 M18626 GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY.html Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. 2/8 Gene Ontology MF GO:0016175 0.000390739678596803 0.000724759081268264 145 570 616.5 4.34230613289755e-05 143 1.25029259386625 -0.75064689990127 -1 7.70650592846309 831 144 781 NA 452 895 859 360 143 365 870 689 M18081 GO_ADRENERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_ACTIVITY.html Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. 4/26 Gene Ontology MF GO:0004935 0.05775893780199 0.0758034561737957 620 628.363636363636 618 0.00593175053345827 326 1.0818214294583 1.0818214294583 1 2.37923402598597 618 566 661 544 773 902 822 326 605 475 620 690 M18276 GO_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_ACTIVITY.html Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 2/27 Gene Ontology MF GO:0008066 0.051586443380077 0.068385486901543 510 615.1 618.5 0.00586767651359777 324 0.597600669636257 -0.597600669636257 -1 1.36676363046361 506 730 703 NA 731 481 534 324 803 817 522 691 M18525 GO_RETINAL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_BINDING.html Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. 3/18 Gene Ontology MF GO:0016918 0.025150595298658 0.0353800423161549 565 605.454545454545 619 0.00254398623147472 277 2.34985618113092 -2.34985618113092 -1 6.69459044798756 562 774 763 707 726 551 619 277 676 436 569 692 M19179 GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_.html Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. 9/15 Gene Ontology MF GO:0031078 0.0366147076271075 0.0497745142593559 510 627.636363636364 619 0.00372323662977248 360 0.925759032579743 -0.879761707535448 -1 2.3680071820336 509 458 908 360 622 619 614 592 671 914 637 693 M17927 GO_DNA_BINDING_BENDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BINDING_BENDING.html The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. 9/24 Gene Ontology MF GO:0008301 0.0765897756730953 0.0971897843024106 740 603.818181818182 620 0.00793650793650794 394 1.54046302782886 -1.70794822774462 -1 3.06152323488447 737 469 620 394 672 604 703 711 609 454 669 694 M18454 GO_OLIGOPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOPEPTIDE_BINDING.html Interacting selectively and non-covalently with an oligopeptide. 10/20 Gene Ontology MF GO:1900750 0.0390555081363574 0.0528398051256601 845 651.454545454545 620 0.00361514343958359 349 1.14414070620112 -1.48767461356002 -1 2.86831282688729 845 468 349 464 620 917 886 818 474 491 834 695 M18239 GO_ANDROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an androgen receptor. 29/64 Gene Ontology MF GO:0050681 0.04799252812416 0.0638974325242073 630 591.090909090909 621 0.00446114626649677 342 1.62423438429088 -1.45639354589756 -1 3.80876237222738 900 813 359 389 630 621 627 511 342 502 808 696 M18641 GO_MHC_CLASS_I_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 22/68 Gene Ontology MF GO:0042288 0.0839184282471183 0.101186047165595 680 641 621 0.00793650793650794 420 1.54535486585409 -1.30071636842609 -1 3.01815568099589 582 816 420 679 804 444 547 881 621 677 580 697 M18725 GO_CCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a CCR chemokine receptor. 12/50 Gene Ontology MF GO:0048020 0.00323179336030211 0.00520709262955857 530 596.727272727273 622 0.00029423187651626 249 1.66181660326549 1.95952492470059 1 7.44918877971314 676 530 249 622 527 882 848 427 669 379 755 698 M18965 GO_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. 52/315 Gene Ontology MF GO:0003823 0.0131389008219062 0.0191869662796091 645 571.363636363636 622 0.00120163924977212 195 2.04334760723431 2.18343177685714 1 6.88737846629403 643 622 195 369 575 891 697 714 454 334 791 699 M18976 GO_MHC_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 28/83 Gene Ontology MF GO:0042287 0.0407991558581423 0.054876057586975 295 546.545454545455 623 0.00377963868190332 198 1.91942086110913 2.49829952242628 1 4.75003048646447 743 630 198 411 623 784 866 396 294 294 773 700 M18087 GO_HISTONE_DEACETYLASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone deacetylase. 67/158 Gene Ontology MF GO:0042826 9.02768576443085e-06 3.07610033454681e-05 855 628.272727272727 624 8.20702073608526e-07 247 1.29475565568676 -1.03652653902261 -1 11.4683214809194 855 736 364 488 247 594 920 800 624 531 752 701 M18591 GO_PEPTIDE_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen peptide. 23/62 Gene Ontology MF GO:0042605 0.0839184282471183 0.101186047165595 620 614.363636363636 624 0.00793650793650794 322 1.43589221904212 1.3859869093034 1 2.80436962629985 617 624 322 662 655 780 628 545 617 504 804 702 M18596 GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING.html Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. 46/115 Gene Ontology MF GO:0008135 0.35943518917414 0.396499249448692 580 675.727272727273 625 0.0396825396825397 425 0.869344158503422 -0.691973236096421 -1 0.68564421413451 576 908 603 880 829 425 484 625 731 761 611 703 M18443 GO_RNA_POLYMERASE_CORE_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_CORE_ENZYME_BINDING.html Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. 11/29 Gene Ontology MF GO:0043175 0.106775860313014 0.126589937484501 495 625.363636363636 626 0.0102127406417821 493 0.336515966730366 0.318911924648827 1 0.59296880286537 493 626 533 666 652 609 542 554 691 840 673 704 M17876 GO_SYNTAXIN_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_1_BINDING.html Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. 9/27 Gene Ontology MF GO:0017075 0.147859119791321 0.171972680414685 615 639.090909090909 627 0.0158730158730159 473 1.85218955022902 1.85218955022902 1 2.77989847783154 596 611 612 487 784 750 791 640 659 627 473 705 M18793 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin-like growth factor receptor. 6/26 Gene Ontology MF GO:0005159 0.295911134218904 0.332731517926242 500 651.181818181818 627 0.0344767243966623 394 0.331675972566317 0.352583548729275 1 0.311171214993444 496 707 819 558 689 601 394 544 856 872 627 706 M18944 GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING.html Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 8/25 Gene Ontology MF GO:0090079 0.0403023239955984 0.0543667713723615 630 667.818181818182 627 0.00410524683568789 517 0.410389528650757 -0.410389528650757 -1 1.01886168870195 632 599 860 645 627 517 559 627 819 886 575 707 M19069 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC.html Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 8/18 Gene Ontology MF GO:0000983 0.00673831233778389 0.0102129280902161 645 612.636363636364 627 0.000675883214627955 323 1.82052676751721 1.82052676751721 1 7.11505964360487 641 627 888 323 559 818 592 381 646 613 651 708 M18049 GO_POLY_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_BINDING.html Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. 9/22 Gene Ontology MF GO:0008143 1.54529651590676e-05 4.74774169856093e-05 460 550.727272727273 629 1.54530726174788e-06 47 2.90125213276768 2.90125213276768 1 24.6243760136427 459 901 651 710 895 658 513 47 217 629 378 709 M18321 GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. 25/81 Gene Ontology MF GO:0004715 0.0839184282471183 0.101186047165595 300 577.545454545455 630 0.00793650793650794 298 1.15680511006786 -0.948776203317563 -1 2.2592984656635 603 641 300 597 832 298 640 732 630 639 441 710 M18335 GO_O_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. 11/20 Gene Ontology MF GO:0008171 0.000702272023949691 0.00124727849813459 565 624.909090909091 630 6.38632999670489e-05 380 0.630803980691287 -0.834014641732482 -1 3.59616405873861 782 380 482 630 472 777 683 564 713 827 564 711 M17992 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. 5/10 Gene Ontology MF GO:0052629 0.147859119791321 0.171972680414685 525 641.636363636364 631 0.0158730158730159 464 1.05298836246055 -1.05298836246055 -1 1.58040016402981 569 916 631 700 732 524 799 464 658 523 542 712 M17986 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 12/29 Gene Ontology MF GO:0016894 0.00338112107928652 0.0054286760784356 655 584.545454545455 632 0.000307848058352607 332 1.15542598153645 -1.15542598153645 -1 5.13821191970406 655 576 429 693 529 645 722 332 679 538 632 713 M18824 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. 29/69 Gene Ontology MF GO:0030374 6.25279874142804e-05 0.000146375950181013 365 642.272727272727 632 5.68452405852088e-06 361 1.05447500663162 -1.05652337209705 -1 7.93764109867364 899 623 493 361 361 914 824 672 632 602 684 714 M19051 GO_METALLOAMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOAMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 7/13 Gene Ontology MF GO:0070006 0.00522829978882559 0.00812506048263436 550 659.272727272727 633 0.000524064147837238 393 1.87442665394489 -1.77869685906771 -1 7.69119396703243 864 498 878 493 550 550 633 866 675 393 852 715 M18330 GO_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. 42/81 Gene Ontology MF GO:0004527 0.051484074353043 0.0683482660963918 255 553.909090909091 634 0.00479362820514262 208 0.964984789039496 -0.765841716278405 -1 2.20745036866086 253 778 547 853 676 208 301 695 634 724 424 716 M18450 GO_LAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMIN_BINDING.html Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. 12/29 Gene Ontology MF GO:0005521 0.298735036746822 0.332731517926242 885 637.545454545455 634 0.0317460317460317 463 2.02898781386349 2.02898781386349 1 1.90355292200799 529 881 476 714 883 634 463 566 711 670 486 717 M19203 GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. 8/13 Gene Ontology MF GO:0046030 0.214139132665174 0.243520398086477 635 646.181818181818 634 0.0238095238095238 428 0.872695360079577 -1.03228298181716 -1 1.05098175124991 634 676 915 528 805 523 742 604 682 428 571 718 M18462 GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. 16/35 Gene Ontology MF GO:0004033 0.000261517490642363 0.000508659812665908 635 584.363636363636 635 2.37771438923549e-05 354 1.34524443128506 1.25013589240628 1 8.6978404716732 658 597 366 683 427 635 635 719 541 354 813 719 M17984 GO_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. 25/47 Gene Ontology MF GO:0033558 0.0241260429955462 0.0340428827544517 820 674.727272727273 636 0.0022177048256167 523 0.980737762739721 -0.904151873107254 -1 2.82627327409889 820 716 523 611 598 548 797 890 636 698 585 720 M18718 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase. 162/400 Gene Ontology MF GO:0044389 0.00151503278061306 0.00257639585612572 870 614.363636363636 636 0.000137825192440722 361 1.35603586548704 -1.00915911227519 -1 6.89198162231525 867 567 446 636 500 512 778 676 361 719 696 721 M17880 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. 19/59 Gene Ontology MF GO:0016620 0.000242233558591626 0.000477205297439606 785 590.454545454545 637 2.20236576464906e-05 311 1.79193086481003 -1.93578407753223 -1 11.6834651361449 781 673 316 509 422 637 752 792 488 311 814 722 M17910 GO_VITAMIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 12/33 Gene Ontology MF GO:0051183 0.000294153197501706 0.000562621500419064 640 538.636363636364 638 2.67447759011365e-05 157 1.91739523341586 1.57701071621052 1 12.2323273603941 638 496 162 641 435 886 810 683 264 157 753 723 M18722 GO_RNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. 34/69 Gene Ontology MF GO:0003724 0.660881834795666 0.699667765261234 870 700.272727272727 638 0.0936318388388618 461 0.707991537080542 -0.707991537080542 -1 0.215578501373802 531 866 591 836 872 461 578 638 886 867 577 724 M18804 GO_RETINOID_X_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOID_X_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a retinoid X receptor. 8/25 Gene Ontology MF GO:0046965 0.190018648277172 0.217976504258103 450 608.181818181818 638 0.0208538919130019 322 1.01364828649144 1.01364828649144 1 1.31649556733729 449 791 821 638 671 420 322 663 837 611 467 725 M18428 GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS.html Catalysis of the hydrolysis of any glycosyl bond. 49/134 Gene Ontology MF GO:0016798 0.000957650831644867 0.00167497864089977 885 640.909090909091 639 8.70970861162957e-05 311 1.55884694617109 -1.42317233777448 -1 8.49502155085772 885 639 311 840 485 756 764 603 526 533 708 726 M17862 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase. 18/31 Gene Ontology MF GO:0051019 0.000255055470774076 0.000498197522531105 730 653.818181818182 641 2.31895495684616e-05 421 1.32280015053101 -1.65992492860229 -1 8.57616255399001 730 596 421 460 426 916 845 769 535 641 853 727 M18023 GO_CYTOSKELETAL_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. 6/18 Gene Ontology MF GO:0008093 0.000320041418865112 0.000608343192884097 700 637.909090909091 641 3.20087520139192e-05 442 0.675683096498037 -0.766942934428144 -1 4.26561850891966 700 479 641 494 442 693 829 526 614 789 810 728 M18115 GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING.html Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. 334/977 Gene Ontology MF GO:0001067 1.90458247578421e-06 1.06055226959349e-05 790 565.636363636364 642 1.73144011329093e-07 139 1.56500113062786 1.66341516690654 1 15.2828478668074 789 525 177 758 139 655 642 847 407 517 766 729 M18882 GO_HYALURONIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONIC_ACID_BINDING.html Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. 5/24 Gene Ontology MF GO:0005540 3.2901518069774e-06 1.44139983924724e-05 870 566.909090909091 642 3.29015667828206e-07 154 1.61815513839886 -1.20529424419756 -1 15.3786273774512 868 210 838 348 192 823 881 642 494 154 786 730 M18682 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. 4/13 Gene Ontology MF GO:0050664 0.001190040713677 0.00205025740933116 485 631.636363636364 643 0.00011906784830165 482 1.25029259386625 -0.75064689990127 -1 6.59803896493243 783 510 797 576 494 773 482 643 660 482 748 731 M18893 GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. 7/18 Gene Ontology MF GO:0042975 0.0264696133017006 0.0370091857713747 790 668.909090909091 643 0.00267902905856817 241 1.73843810340423 -0.877741928686536 -1 4.8859763461532 787 638 841 241 608 920 723 451 643 597 909 732 M19033 GO_MISFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with a misfolded protein. 11/19 Gene Ontology MF GO:0051787 0.0839184282471183 0.101186047165595 735 618.181818181818 644 0.00793650793650794 382 1.53061998428422 -1.53061998428422 -1 2.98937771619255 733 805 382 438 792 525 644 730 627 663 461 733 M19136 GO_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. 28/60 Gene Ontology MF GO:0003678 0.856665040572803 0.89155185217984 750 673.181818181818 644 0.161882828034024 413 0.303648467711652 -0.327258111076145 -1 0.029717167609682 413 749 545 746 777 530 566 639 889 907 644 734 M18767 GO_TYPE_I_INTERFERON_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_I_INTERFERON_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). 2/17 Gene Ontology MF GO:0005132 0.320523531548456 0.355707658654498 505 657.4 644.5 0.0420282251989943 470 0.270733914333385 -0.270733914333385 -1 0.238584188218015 502 688 811 NA 717 473 601 470 884 869 559 735 M17940 GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. 19/38 Gene Ontology MF GO:0004003 0.751818926255892 0.789581520725366 600 680.363636363636 647 0.118993791304126 536 0.276586837756504 -0.305465274685395 -1 0.0557100980740835 599 775 556 806 749 536 599 569 869 779 647 736 M18409 GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. 7/15 Gene Ontology MF GO:0048531 0.0765897756730953 0.0971897843024106 650 649.454545454545 647 0.00793650793650794 562 0.81758874661125 -0.658629494597096 -1 1.62487955210987 601 647 734 748 658 646 678 681 597 592 562 737 M18568 GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. 17/31 Gene Ontology MF GO:0004683 0.0240417577027962 0.0339760631130146 670 648.272727272727 647 0.00220987081545599 387 1.27865568242905 0.892968524060153 1 3.6869498893094 670 439 395 387 597 833 768 888 647 626 881 738 M19171 GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any O-glycosyl bond. 39/105 Gene Ontology MF GO:0004553 2.80442662522313e-05 7.54407162340726e-05 885 584.909090909091 647 2.54951124999234e-06 234 1.55884694617109 -1.42317233777448 -1 12.6152538402134 883 385 234 647 317 848 776 690 461 396 797 739 M17868 GO_IMMUNOGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_BINDING.html Interacting selectively and non-covalently with an immunoglobulin. 4/24 Gene Ontology MF GO:0019865 0.147859119791321 0.171972680414685 815 664.181818181818 648 0.0158730158730159 473 1.85426666510063 -1.85426666510063 -1 2.78301596041816 811 549 610 554 693 815 478 762 648 473 913 740 M18020 GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding. 10/22 Gene Ontology MF GO:0044183 0.0839184282471183 0.101186047165595 380 604.454545454545 648 0.00793650793650794 339 1.55472028813083 -0.798937678752718 -1 3.03644682174042 378 873 384 344 787 683 895 712 606 648 339 741 M18036 GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY.html Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. 6/15 Gene Ontology MF GO:0034450 0.00304619896287078 0.00493398423563577 820 640.636363636364 648 0.000305038273436313 201 0.801837395285819 -0.801837395285819 -1 3.63111214720479 462 820 646 873 736 451 648 201 820 791 599 742 M18579 GO_CHAPERONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_BINDING.html Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. 67/131 Gene Ontology MF GO:0051087 0.0839184282471183 0.101186047165595 680 627.818181818182 648 0.00793650793650794 353 1.59605663719123 -1.20409259885518 -1 3.11717879048535 648 678 448 665 888 498 609 803 353 640 676 743 M18045 GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. 7/13 Gene Ontology MF GO:0052744 0.358111057914406 0.395988189039968 600 661.090909090909 649 0.0433656096407684 467 1.05298836246055 -1.05298836246055 -1 0.831640701447664 597 874 649 780 725 467 787 473 826 586 508 744 M18340 GO_LYSOZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOZYME_ACTIVITY.html Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3/15 Gene Ontology MF GO:0003796 0.147859119791321 0.171972680414685 720 607.272727272727 649 0.0158730158730159 393 3.33411533230694 -3.33411533230694 -1 5.00407870176877 636 427 718 393 716 742 731 660 649 435 573 745 M18470 GO_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 24/81 Gene Ontology MF GO:0003777 0.532769144227252 0.571267613856727 500 631.363636363636 649 0.066837215140846 360 0.856622349182466 -0.902905223731032 -1 0.408907563031791 499 625 405 764 808 528 360 649 853 732 722 746 M18046 GO_PROTEIN_DIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DIMERIZATION_ACTIVITY.html The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. 581/1514 Gene Ontology MF GO:0046983 1.89247968172243e-06 1.06055226959349e-05 665 522 650 1.89248129339006e-07 133 1.62387048127537 -1.32117870907005 -1 15.8577300940639 665 428 650 591 147 686 732 654 385 133 671 747 M18406 GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 434/1422 Gene Ontology MF GO:0001071 1.67943144622384e-05 5.06582600172436e-05 920 638.090909090909 651 1.52676751524533e-06 281 1.4182108744719 -1.35049604452962 -1 11.9586550908183 917 784 346 895 281 457 800 739 525 651 624 748 M18240 GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other. 11/17 Gene Ontology MF GO:0042887 0.00341359352134025 0.00547126487740945 780 594.454545454545 652 0.000310809245600069 206 1.65911533451788 -0.984507395319023 -1 7.36707902542835 779 373 206 446 530 868 766 797 652 351 771 749 M18798 GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. 10/16 Gene Ontology MF GO:0004549 1.72144036555371e-05 5.09090363264905e-05 690 624 652 1.56495803227773e-06 285 0.817827137870305 -0.817827137870305 -1 6.89264883787513 686 504 532 589 285 724 777 658 584 873 652 750 M19011 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery. 53/114 Gene Ontology MF GO:0001104 2.79015610434788e-05 7.52980273386956e-05 715 590.181818181818 652 2.53653771928037e-06 316 1.45305805798541 1.37634423942793 1 11.761483259141 712 715 399 652 316 864 754 445 381 355 899 751 M18056 GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. 7/21 Gene Ontology MF GO:1990939 0.683252645473634 0.720862882839155 870 660.727272727273 653 0.108602730090908 415 0.489718252397159 0.415588485986193 1 0.1366556874469 443 582 653 697 791 544 415 868 867 796 612 752 M18616 GO_METAL_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_CLUSTER_BINDING.html Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. 36/69 Gene Ontology MF GO:0051540 0.0839184282471183 0.101186047165595 525 660.181818181818 657 0.00793650793650794 495 1.10906902141818 -0.650319840722573 -1 2.16606748362297 523 748 495 803 728 497 657 879 563 735 634 753 M18072 GO_RNA_POLYMERASE_I_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_I_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 5/14 Gene Ontology MF GO:0001054 0.380898244318571 0.418169910230412 560 653.181818181818 660 0.0468171855668264 331 0.166013216856588 -0.193487899503387 -1 0.123401404164838 558 727 660 723 854 431 331 609 896 799 597 754 M18112 GO_POLY_PYRIMIDINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PYRIMIDINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. 11/26 Gene Ontology MF GO:0008187 0.0592282539650864 0.0775106595275668 635 657 660 0.00553505519706639 320 1.34960585237647 -0.689550038146136 -1 2.94254214352737 635 694 379 594 775 912 867 320 738 660 653 755 M18717 GO_AU_RICH_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AU_RICH_ELEMENT_BINDING.html Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. 10/26 Gene Ontology MF GO:0017091 0.171339471110664 0.197040391777264 650 689.181818181818 660 0.0169407461227753 392 1.082377024765 -1.082377024765 -1 1.49894099590255 660 882 507 867 739 650 783 392 834 650 617 756 M18760 GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 307/779 Gene Ontology MF GO:0000988 1.19668286635783e-06 7.69893872062377e-06 680 623.727272727273 660 1.08789410662735e-07 111 1.54876618785045 1.60359913952079 1 15.5472288221157 677 785 389 660 111 854 629 880 345 615 916 757 M19071 GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 164/384 Gene Ontology MF GO:0003713 1.2621347837204e-06 7.8990748368896e-06 675 600.818181818182 660 1.14739591618611e-07 116 1.50117377438245 1.48652451575219 1 15.0366293114209 671 851 396 555 116 842 660 673 394 534 917 758 M18723 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. 11/32 Gene Ontology MF GO:0016538 0.231465862412523 0.262575330973516 510 594.181818181818 661 0.0236495244885343 267 1.02225042359124 -1.02225042359124 -1 1.16543096117578 507 741 426 725 771 399 267 686 828 661 525 759 M18864 GO_TRANSLATION_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY.html Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 16/42 Gene Ontology MF GO:0045182 0.0839184282471183 0.101186047165595 825 667.727272727273 661 0.00793650793650794 510 1.37039633224333 -1.18568261638898 -1 2.67645286523722 821 712 510 709 661 768 842 540 511 617 654 760 M18927 GO_RETINOL_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. 9/32 Gene Ontology MF GO:0004745 0.158647435510863 0.183592000842759 665 660.818181818182 661 0.0171261007795942 554 1.03531454031464 0.924583904230022 1 1.49616464863344 566 606 854 670 664 661 554 635 693 635 731 761 M18221 GO_PHOSPHOLIPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_BINDING.html Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. 15/29 Gene Ontology MF GO:0043274 0.0964618162692239 0.114954496072132 735 689.090909090909 662 0.00917914909639374 485 1.98057969718709 -1.98057969718709 -1 3.65275123943171 732 645 485 625 650 798 910 498 662 696 879 762 M18042 GO_PROTEASOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_BINDING.html Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. 10/20 Gene Ontology MF GO:0070628 0.0839184282471183 0.101186047165595 810 691.363636363636 663 0.00793650793650794 428 1.41829028389675 -1.55702569971744 -1 2.76999216166385 809 718 428 663 790 892 659 651 608 489 898 763 M18533 GO_GLUCOCORTICOID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glucocorticoid receptor. 9/19 Gene Ontology MF GO:0035259 0.158501962931232 0.183592000842759 525 638.181818181818 663 0.017109107894095 375 0.775052495160171 -0.775052495160171 -1 1.12005199760058 521 680 764 505 663 428 375 897 821 848 518 764 M18592 GO_DYNEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_BINDING.html Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. 13/55 Gene Ontology MF GO:0045502 0.0839184282471183 0.101186047165595 830 641.818181818182 664 0.00793650793650794 362 1.47295271268273 -1.76357972692709 -1 2.87675063435389 829 818 425 664 740 838 745 362 508 573 558 765 M19189 GO_PROTEIN_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHANNEL_ACTIVITY.html Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel. 4/12 Gene Ontology MF GO:0015266 0.392468844579604 0.429846829777662 665 659.818181818182 664 0.0486137828890717 339 0.187710286878756 -0.28596298483566 -1 0.135121798540825 664 698 911 556 812 391 339 561 893 917 516 766 M18364 GO_DIACYLGLYCEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_BINDING.html Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. 6/14 Gene Ontology MF GO:0019992 0.523711907510831 0.562211149253168 650 627.181818181818 665 0.0714891726627913 338 1.2825637026791 -1.10841243744414 -1 0.629704099924895 649 720 723 485 727 732 422 665 817 338 621 767 M18419 GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. 11/23 Gene Ontology MF GO:0070003 0.669424338390072 0.707084260986069 550 675.636363636364 665 0.0957316045318931 407 0.193785754459461 -0.272613526465299 -1 0.0572642800458931 547 752 562 765 863 505 407 659 871 836 665 768 M18589 GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY.html Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 5/17 Gene Ontology MF GO:0003906 0.131371470792223 0.154554671520263 525 661.727272727273 666 0.013985256288843 376 0.654162550255648 -0.654162550255648 -1 1.04137106772251 522 666 774 531 897 454 828 494 882 855 376 769 M18739 GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. 11/18 Gene Ontology MF GO:0015101 0.232850105696956 0.263495814564821 790 666.636363636364 666 0.0238095238095238 427 0.887009599117636 -0.616670821008669 -1 1.00860133281844 786 573 427 569 909 666 550 842 692 513 806 770 M17896 GO_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVITY.html Catalysis of the reaction: GTP + H2O = GDP + phosphate. 129/266 Gene Ontology MF GO:0003924 0.0839184282471183 0.101186047165595 870 669 667 0.00793650793650794 448 1.32923189589327 -1.32738122151284 -1 2.59605665066202 866 721 451 841 659 616 897 679 514 448 667 771 M18564 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). 9/21 Gene Ontology MF GO:0016755 0.16984656234152 0.195568006701124 685 628.272727272727 668 0.0184422937566174 459 1.05856416783199 -1.13302697432017 -1 1.47273272878753 685 544 770 659 668 681 714 465 791 459 475 772 M18903 GO_ZINC_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_BINDING.html Interacting selectively and non-covalently with zinc (Zn) ions. 477/1372 Gene Ontology MF GO:0008270 1.80957791764795e-06 1.02824978679606e-05 715 586.545454545455 668 1.64507218735599e-07 123 1.36868809303465 -1.18752612971336 -1 13.4018682976302 714 886 574 899 137 123 668 750 548 755 398 773 M18478 GO_DOUBLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA. 317/898 Gene Ontology MF GO:0003690 2.62370765626603e-06 1.25067929728743e-05 705 617.272727272727 669 2.38519162299117e-07 168 1.55717563881551 1.70411356092981 1 14.9875127166762 704 614 293 810 168 747 636 830 413 669 906 774 M18309 GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. 8/15 Gene Ontology MF GO:0008239 0.632427457617131 0.671087959639862 710 664.636363636364 671 0.0952380952380952 457 0.576204456302563 0.576204456302563 1 0.19593806842789 457 671 710 708 796 590 536 617 785 819 622 775 M18062 GO_PRENYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRENYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). 7/16 Gene Ontology MF GO:0004659 0.0274274830670786 0.0382322491238066 675 670.545454545455 672 0.00277720029724192 478 0.811573523468565 -0.811573523468565 -1 2.25847566061492 672 665 656 624 610 690 696 726 762 797 478 776 M17887 GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. 4/16 Gene Ontology MF GO:0004115 0.00528106517858281 0.00819322085041515 675 643.909090909091 673 0.000529365765901764 461 1.38329240566274 1.38329240566274 1 5.66610754771293 673 461 615 577 551 805 781 725 740 474 681 777 M18362 GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. 12/29 Gene Ontology MF GO:0008106 0.00546434498472255 0.00842076614061097 865 674.363636363636 674 0.000497996788270224 397 1.23002270663632 -1.53546150904261 -1 5.00957204593425 865 674 397 642 546 852 837 680 566 543 816 778 M18627 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. 8/22 Gene Ontology MF GO:0016864 0.102679829867718 0.121890894810711 410 591.454545454545 675 0.0107757754702521 202 0.787873631500732 0.787873631500732 1 1.41370693232856 406 675 782 774 846 357 202 428 758 857 421 779 M19067 GO_TAU_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. 8/26 Gene Ontology MF GO:0050321 0.00894954505916587 0.0133445404447854 545 652.272727272727 675 0.000898579314484864 417 0.45531460743864 0.45531460743864 1 1.67565845123869 542 417 887 437 567 675 500 789 764 897 700 780 M18277 GO_GAMMA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. 13/46 Gene Ontology MF GO:0043015 0.0598035867044789 0.0781524144433531 760 675.454545454545 679 0.00559035866568726 498 0.731017336099662 0.837938588931315 1 1.58869624948296 612 609 498 559 636 775 758 757 778 679 769 781 M18294 GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription. 13/36 Gene Ontology MF GO:0001103 0.298735036746822 0.332731517926242 705 631.636363636364 680 0.0317460317460317 258 1.15359118176843 -0.761786197577807 -1 1.08227450432784 875 258 443 455 706 571 914 705 702 680 639 782 M18731 GO_GUANYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. 186/417 Gene Ontology MF GO:0019001 0.000629721098618245 0.001122758547924 685 673.090909090909 682 5.72637654795282e-05 448 1.45021648916375 1.52591523225059 1 8.39760980260231 682 668 462 859 470 809 759 883 448 472 892 783 M19091 GO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_BINDING.html Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. 167/380 Gene Ontology MF GO:0051020 4.77003226009868e-07 4.87603297698976e-06 835 586.181818181818 682 4.33639390394155e-08 49 1.27574953522844 -1.20122404114706 -1 13.3033505929803 833 410 435 690 49 682 737 843 554 508 707 784 M17949 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 14/38 Gene Ontology MF GO:0001106 0.298735036746822 0.332731517926242 695 625.363636363636 684 0.0317460317460317 401 1.0539435623955 1.0539435623955 1 0.988787236769673 692 723 447 701 684 401 589 610 715 687 630 785 M18027 GO_CARBOXY_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_LYASE_ACTIVITY.html Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. 14/37 Gene Ontology MF GO:0016831 0.463529159245374 0.504074263009154 730 613.272727272727 684 0.0550403079343074 312 0.914753407761816 0.816500215455221 1 0.534246793570574 726 425 312 801 765 484 342 684 795 583 829 786 M18204 GO_NADPH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADPH_BINDING.html Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. 9/16 Gene Ontology MF GO:0070402 1.10547042827152e-05 3.59375545586502e-05 690 571 686 1.10547592760193e-06 238 1.35051372826151 -0.731139479815824 -1 11.7831164924483 806 290 686 238 262 688 779 877 305 455 895 787 M18729 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. 94/232 Gene Ontology MF GO:0061659 0.0839184282471183 0.101186047165595 755 672.363636363636 686 0.00793650793650794 474 1.16236826834347 -1.03179484594457 -1 2.27016359357728 751 878 559 878 794 474 686 557 562 751 506 788 M18771 GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY.html Modulation of the activity of the enzyme protein phosphatase type 2A. 9/22 Gene Ontology MF GO:0008601 0.0765897756730953 0.0971897843024106 755 621.909090909091 688 0.00793650793650794 63 1.89121657864655 -0.554170537432062 -1 3.75861246061294 753 533 814 322 688 789 724 895 63 631 629 789 M18972 GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. 6/12 Gene Ontology MF GO:0004535 0.297820313904066 0.332731517926242 905 695 688 0.0347388518996436 354 0.144812083610322 -0.167915912461313 -1 0.13585950665839 588 902 863 688 884 355 354 668 901 887 555 790 M18975 GO_DOUBLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with double-stranded RNA. 64/150 Gene Ontology MF GO:0003725 0.0839184282471183 0.101186047165595 910 681.818181818182 689 0.00793650793650794 379 1.37622785458795 1.59508978365254 1 2.68784212167526 910 862 402 689 827 627 851 538 379 666 749 791 M17920 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 4/10 Gene Ontology MF GO:0016888 0.175639464001964 0.201733217080907 810 692.909090909091 690 0.0191293958535622 404 0.396770043283601 -0.396770043283601 -1 0.54150899181783 810 677 618 699 673 649 690 404 888 775 739 792 M18205 GO_SINGLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with single-stranded RNA. 52/138 Gene Ontology MF GO:0003727 0.0839184282471183 0.101186047165595 800 667.454545454545 691 0.00793650793650794 401 1.35459102942655 -1.06754347562553 -1 2.64558431390136 814 800 401 634 691 708 827 518 529 624 796 793 M18541 GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. 12/25 Gene Ontology MF GO:0015035 0.116028385073486 0.137029671717082 695 672.363636363636 691 0.0111492293544221 364 0.665357279786738 -0.665357279786738 -1 1.12746210958582 691 872 475 832 810 614 503 364 891 850 494 794 M18228 GO_S100_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_S100_PROTEIN_BINDING.html Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. 9/20 Gene Ontology MF GO:0044548 2.04704715609981e-05 5.83059871087254e-05 750 589.272727272727 693 2.04706601315356e-06 287 1.08046039285939 -1.07212527115075 -1 8.98115361216863 749 446 693 287 302 734 830 884 729 456 372 795 M18886 GO_TRANSLATION_REPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REPRESSOR_ACTIVITY.html Antagonizes ribosome-mediated translation of mRNA into a polypeptide. 7/22 Gene Ontology MF GO:0030371 0.161230774692306 0.186347126528796 695 710.636363636364 694 0.0174283060484013 596 1.73982376395204 1.73982376395204 1 2.49217812450086 628 685 840 694 666 808 711 815 680 596 694 796 M19180 GO_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_BINDING.html Interacting selectively and non-covalently with an RNA molecule or a portion thereof. 910/2094 Gene Ontology MF GO:0003723 0.0765897756730953 0.0971897843024106 895 687.545454545455 694 0.00793650793650794 350 1.10744526942964 -0.964479930594736 -1 2.20094174333437 351 905 909 894 894 350 501 694 623 915 527 797 M18246 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. 6/14 Gene Ontology MF GO:0004861 0.250528491881754 0.282458593788252 765 700.545454545455 695 0.0284268311543542 515 0.442759662990993 -0.283667593505408 -1 0.477220474068989 765 726 695 763 682 587 515 636 833 814 690 798 M18634 GO_3_5_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_DNA_HELICASE_ACTIVITY.html Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. 7/13 Gene Ontology MF GO:0043138 0.417338296548623 0.455458164679399 490 640.272727272727 695 0.0525819655625161 368 0.286762567756733 -0.317104978869562 -1 0.192274394676014 487 695 784 724 743 402 368 571 881 859 529 799 M18987 GO_2_IRON_2_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_IRON_2_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. 12/29 Gene Ontology MF GO:0051537 0.048759745551398 0.064825095241743 785 700 695 0.00453410928165265 449 0.739614016513101 0.883607872628086 1 1.72527541094281 784 650 509 695 631 867 875 449 714 671 855 800 M18293 GO_MANNOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSE_BINDING.html Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. 7/23 Gene Ontology MF GO:0005537 0.0401108510329825 0.0541879338477884 600 649.545454545455 698 0.0040853791413434 299 2.02821175608397 -2.02821175608397 -1 5.04107790920266 600 782 705 529 866 698 708 299 726 590 642 801 M17935 GO_BHLH_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BHLH_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. 16/36 Gene Ontology MF GO:0043425 0.0303424585234835 0.041977536603917 860 708.454545454545 701 0.00279720050988444 380 1.36294805261998 1.79268750861113 1 3.684265243931 857 770 380 572 612 676 838 899 685 701 803 802 M17958 GO_SIGNAL_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. 16/50 Gene Ontology MF GO:0005048 0.298735036746822 0.332731517926242 705 646.272727272727 702 0.0317460317460317 411 1.93331607460506 1.93331607460506 1 1.81379574022991 429 780 411 736 843 638 597 702 705 702 566 803 M18025 GO_RACEMASE_AND_EPIMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RACEMASE_AND_EPIMERASE_ACTIVITY.html Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. 4/18 Gene Ontology MF GO:0016854 0.0767261457572278 0.0972287246510325 645 692.909090909091 702 0.00795115979652593 254 1.10282801975978 -1.13101199113472 -1 2.19138875925605 848 702 642 604 645 644 706 905 792 254 880 804 M18787 GO_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 37/84 Gene Ontology MF GO:0019209 7.19550063557314e-05 0.000166747118003206 720 568.181818181818 704 6.54157817118337e-06 273 1.39676786786353 -1.2175491716909 -1 10.3591108789243 718 704 351 359 364 717 763 824 273 356 821 805 M18490 GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 3/12 Gene Ontology MF GO:0015129 0.408685821811846 0.447076047641972 835 682.909090909091 705 0.0511843722872189 469 0.524542258705949 0.531548431248682 1 0.360012760122883 629 560 752 580 709 599 469 834 832 843 705 806 M18859 GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. 7/39 Gene Ontology MF GO:0005251 0.214139132665174 0.243520398086477 710 689.818181818182 706 0.0238095238095238 224 1.17712956556802 1.17629467110484 1 1.41761005980391 706 653 830 497 855 812 671 809 686 224 845 807 M18039 GO_ATPASE_ACTIVITY_COUPLED http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. 153/347 Gene Ontology MF GO:0042623 0.0839184282471183 0.101186047165595 785 674.181818181818 707 0.00793650793650794 452 1.63781592204469 -1.25784699679878 -1 3.19873677410586 707 889 502 785 781 452 610 724 524 747 695 808 M18902 GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). 2/13 Gene Ontology MF GO:0005451 0.564292086069944 0.602960184883099 750 686.3 707 0.0881768685041352 408 0.26826021542583 -0.412436290819393 -1 0.115704814715855 747 667 845 NA 750 593 408 531 825 881 616 809 M18891 GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. 24/52 Gene Ontology MF GO:0001102 0.4465884091668 0.48622643364906 910 678.636363636364 710 0.0523657473805834 449 1.8818988242565 -1.8818988242565 -1 1.15693114042682 645 910 449 727 710 568 907 523 769 734 523 810 M19027 GO_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. 383/1167 Gene Ontology MF GO:0043565 3.89707062571577e-05 9.83620109312027e-05 885 655.272727272727 710 3.54285423633709e-06 265 1.53335340841216 1.72915861494396 1 12.062110731244 723 887 265 884 337 710 625 793 456 645 883 811 M18263 GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). 17/47 Gene Ontology MF GO:0016303 0.00201018302163171 0.00335638544446675 865 728.727272727273 711 0.00018291110165314 436 1.09644455348146 -1.14475848163175 -1 5.32539545588523 861 711 436 761 509 861 887 906 689 709 686 812 M18858 GO_GTP_RHO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_RHO_BINDING.html Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. 12/21 Gene Ontology MF GO:0017049 0.0142339448824708 0.0206224083336585 715 664.818181818182 712 0.0013024437326759 353 1.27824341543173 -1.26589407691967 -1 4.22986685638516 891 713 353 484 577 774 712 867 664 382 896 813 M19112 GO_TRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. 13/20 Gene Ontology MF GO:0008175 0.466868320199426 0.505911489497611 660 692.363636363636 713 0.0555765287768793 491 0.445436604010869 -0.445436604010869 -1 0.258768298920408 657 790 504 818 713 491 725 641 841 903 533 814 M18318 GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. 6/11 Gene Ontology MF GO:0008568 0.124220322472432 0.146516277787997 535 647 714 0.0131764927705834 220 0.29427844599554 -0.347632618965681 -1 0.481866621546139 534 917 714 851 820 448 220 424 885 823 481 815 M19191 GO_HISTONE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 15/49 Gene Ontology MF GO:0035173 0.480349633004539 0.519296900545448 745 702.727272727273 715 0.0577729520334567 324 0.818850542433139 0.487253302056808 1 0.457465600622026 834 856 324 744 715 741 664 646 797 697 712 816 M18105 GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY.html Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. 26/75 Gene Ontology MF GO:0003743 0.379303434768649 0.416916559124441 460 656.818181818182 716 0.0424292992526685 378 0.655921534768236 -0.613501412951297 -1 0.489240310144824 458 896 599 874 795 378 436 716 744 801 528 817 M18809 GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING.html Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. 17/34 Gene Ontology MF GO:0001098 2.82592077986122e-05 7.57972920545867e-05 850 683 716 2.56905189066668e-06 318 0.654469179698918 -0.586369831175375 -1 5.29378030021197 850 521 536 776 318 678 661 861 716 875 721 818 M18931 GO_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVITY.html Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. 8/35 Gene Ontology MF GO:0004629 0.0765897756730953 0.0971897843024106 860 666.818181818182 717 0.00793650793650794 341 2.3051336233986 -2.59614464836358 -1 4.58123310570511 856 646 855 341 737 874 717 664 351 427 867 819 M19163 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. 12/82 Gene Ontology MF GO:0016709 0.00496791442355148 0.00777292732936626 590 647.818181818182 717 0.000452651661671005 220 2.56500460235345 -2.66625693182009 -1 10.6216810916357 717 772 220 587 542 746 826 835 586 551 744 820 M18451 GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. 20/54 Gene Ontology MF GO:0052742 0.00617578747607385 0.00940682860594031 725 696.727272727273 718 0.000563017494552818 483 0.992108157322135 -1.00225950439502 -1 3.94694237863233 722 789 483 817 553 684 836 796 672 718 594 821 M19012 GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. 7/20 Gene Ontology MF GO:0008353 0.168004642079254 0.193689562296885 720 647.636363636364 719 0.0182247257342191 305 0.162639489625122 -0.172038234999089 -1 0.227611210377039 481 719 870 677 840 305 315 720 897 891 409 822 M18992 GO_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. 30/81 Gene Ontology MF GO:0019213 0.298735036746822 0.332731517926242 745 690.818181818182 720 0.0317460317460317 485 0.980737762739721 -0.904151873107254 -1 0.92010711954964 744 894 540 745 735 485 646 814 720 715 561 823 M19108 GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. 7/11 Gene Ontology MF GO:0008195 0.00245728211162081 0.00404418522842781 770 578.636363636364 720 0.000246000355381775 87 2.01537636699107 -1.69995781879909 -1 9.46831114325714 780 453 893 340 517 720 769 767 87 228 811 824 M17953 GO_MAGNESIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_BINDING.html Interacting selectively and non-covalently with magnesium (Mg) ions. 114/271 Gene Ontology MF GO:0000287 0.0839184282471183 0.101186047165595 920 726.636363636364 721 0.00793650793650794 559 1.06463945526101 -0.881175078354183 -1 2.07929430631333 919 733 563 857 817 559 720 721 641 753 710 825 M18956 GO_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_BINDING.html Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 239/607 Gene Ontology MF GO:0003682 0.0160855188338284 0.0231229333236283 910 699.909090909091 722 0.00147312253282873 440 1.64055836491736 -1.3677931579915 -1 5.26873776874734 906 848 440 838 584 679 772 722 497 739 674 826 M18057 GO_C2H2_ZINC_FINGER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_C2H2_ZINC_FINGER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. 7/22 Gene Ontology MF GO:0070742 0.76527490244494 0.800970318827469 805 722.636363636364 723 0.134920634920635 587 1.68161259955643 1.68161259955643 1 0.31817925724376 680 758 654 777 802 801 647 723 807 587 713 827 M18644 GO_GABA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. 7/25 Gene Ontology MF GO:0050811 7.89839065816269e-05 0.000181209960237149 890 603.636363636364 723 7.89867140279395e-06 240 0.804721999055612 -0.778853876653268 -1 5.91114375967801 888 240 789 300 370 723 773 446 418 862 831 828 M18310 GO_TOXIC_SUBSTANCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIC_SUBSTANCE_BINDING.html Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems. 3/17 Gene Ontology MF GO:0015643 0.516988792761437 0.556943430141127 785 727 728 0.0701867711717226 509 0.826926585434464 -0.146368698192742 -1 0.412635380169811 703 728 711 773 785 719 682 509 782 820 785 829 M18512 GO_OMEGA_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OMEGA_PEPTIDASE_ACTIVITY.html Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). 10/15 Gene Ontology MF GO:0008242 0.197200998591766 0.225652883960727 460 679 729 0.0197702187880141 410 0.887982960090752 0.763681694186603 1 1.12708282951796 771 457 458 729 831 881 770 410 687 649 826 830 M18514 GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. 3/12 Gene Ontology MF GO:0008970 0.887230231651313 0.921277441443802 685 732.818181818182 730 0.196068086984499 606 0.424736186990789 0.51060898408333 1 0.0296911829063651 681 687 758 775 786 606 675 626 892 845 730 831 M18013 GO_LEUCINE_ZIPPER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUCINE_ZIPPER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. 8/14 Gene Ontology MF GO:0043522 0.562604368603265 0.601855836180237 575 743 733 0.0793650793650794 574 0.411217803807696 -0.219892909782542 -1 0.178007413158189 574 725 638 733 920 847 843 618 770 787 718 832 M18716 GO_PROTEIN_KINASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVITY.html Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. 9/16 Gene Ontology MF GO:0004697 0.0765897756730953 0.0971897843024106 915 688.818181818182 734 0.00793650793650794 288 1.75418627257373 -1.73131236018645 -1 3.48627779788764 914 724 802 503 768 826 734 633 553 288 832 833 M18271 GO_DIPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a dipeptide. 4/14 Gene Ontology MF GO:0016805 0.00304488593557396 0.00493398423563577 790 685.090909090909 735 0.00030490660976304 158 0.822574519072846 -0.822574519072846 -1 3.72501999500703 863 158 702 525 528 788 730 904 735 816 787 834 M18380 GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. 7/25 Gene Ontology MF GO:0008139 0.990192689600717 0.999998588329043 745 741.454545454545 736 0.37026911733223 592 0.992706482639766 0.992706482639766 1 1.09843965311109e-06 592 743 728 742 908 669 624 736 873 832 709 835 M18427 GO_MISMATCHED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCHED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. 6/14 Gene Ontology MF GO:0030983 0.487295666086581 0.526187808450298 485 673.545454545455 738 0.0646229740966323 459 0.231462301684718 0.293900294155688 1 0.126709140707737 483 783 738 813 776 459 509 500 905 837 606 836 M18908 GO_POLY_A_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_RNA_BINDING.html Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. 700/1614 Gene Ontology MF GO:0044822 0.0765897756730953 0.0971897843024106 400 693.272727272727 738 0.00793650793650794 383 1.14683340579285 -0.984041531039801 -1 2.27922190733074 396 906 847 893 875 383 521 738 628 883 556 837 M19161 GO_4_IRON_4_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_IRON_4_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. 25/42 Gene Ontology MF GO:0051539 0.539695926485547 0.578021248389643 550 701.454545454545 738 0.068103435350475 504 0.682272506099739 -0.684843236348928 -1 0.318845455981613 546 815 541 852 745 560 738 504 872 912 631 838 M18343 GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE.html The action of a molecule that contributes to the structural integrity of the nuclear pore complex. 6/14 Gene Ontology MF GO:0017056 0.918096131061857 0.951180676325347 530 738.636363636364 740 0.221371238872335 523 0.138621464372166 0.160747074996757 1 0.00591514836566498 527 884 719 814 838 623 523 740 914 828 715 839 M18028 GO_MIRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIRNA_BINDING.html Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. 7/25 Gene Ontology MF GO:0035198 0.0765897756730953 0.0971897843024106 805 712.727272727273 745 0.00793650793650794 385 1.99560843228131 -1.082377024765 -1 3.96608131232654 805 745 644 655 842 779 905 790 570 385 720 840 M18319 GO_RRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. 7/16 Gene Ontology MF GO:0008649 0.758540451297067 0.795732286423377 755 711.272727272727 747 0.132470126993289 443 0.301501179057101 0.360944678494758 1 0.0587337208716249 615 754 715 732 754 622 443 747 860 824 758 841 M18695 GO_PROTEIN_PHOSPHATASE_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_1_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 1. 9/30 Gene Ontology MF GO:0008157 0.147859119791321 0.171972680414685 800 720.909090909091 747 0.0158730158730159 395 0.711313788642169 -0.741565848784047 -1 1.06759052180641 876 395 800 621 797 680 860 620 668 866 747 842 M17999 GO_ACID_AMINO_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_AMINO_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 13/27 Gene Ontology MF GO:0016881 0.827348629143441 0.862994034934201 460 720.090909090909 748 0.14758355229924 457 0.872355289179605 -0.9771018090378 -1 0.109588025481915 748 900 459 844 833 705 457 608 880 786 701 843 M18775 GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. 37/81 Gene Ontology MF GO:0033613 0.466738071388703 0.505911489497611 860 723.909090909091 749 0.0555555555555556 438 1.92083167389272 1.94029809871083 1 1.1158725672875 678 909 438 705 751 783 499 858 749 737 856 844 M18925 GO_RETINOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_BINDING.html Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. 3/13 Gene Ontology MF GO:0019841 0.921238379748907 0.952291358841567 615 750.545454545455 749 0.22441131571062 527 0.281468978235511 0.281468978235511 1 0.0117306794595448 614 832 852 749 830 656 527 682 898 884 732 845 M18479 GO_TRANSITION_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_BINDING.html Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 586/1709 Gene Ontology MF GO:0046914 1.01138155933453e-06 7.11845079997341e-06 835 649.181818181818 750 1.01138201963652e-07 103 1.43704942452082 -1.2112212340271 -1 14.521809027891 832 861 750 897 103 229 818 852 501 731 567 846 M18872 GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a macromolecule from one side of the membrane to the other. 11/35 Gene Ontology MF GO:0022884 0.63389956273523 0.671875112576511 665 706.818181818182 752 0.0873015873015873 403 2.50346982391423 2.50346982391423 1 0.84880207646999 881 797 403 752 865 664 493 689 774 662 795 847 M19049 GO_THYROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a thyroid hormone receptor. 18/42 Gene Ontology MF GO:0046966 0.000199576972830918 0.000401774212263555 645 716.818181818182 752 1.81450072832856e-05 413 0.957220074847239 0.797731415313051 1 6.38152933423623 763 843 508 644 413 883 864 752 667 644 904 848 M19113 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_.html Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. 7/19 Gene Ontology MF GO:0042800 0.520714469426332 0.560300949558159 575 727.181818181818 753 0.0709064784604187 512 0.434894544427673 -0.434894544427673 -1 0.214783311970181 693 648 895 571 816 574 861 753 772 904 512 849 M18766 GO_SINGLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with single-stranded DNA. 52/108 Gene Ontology MF GO:0003697 0.41130036732253 0.449401826528181 740 756.909090909091 756 0.047025562435006 558 0.805268999103663 -0.609734180699026 -1 0.549123679961192 767 747 558 833 707 736 736 892 811 756 783 850 M18511 GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING.html Interacting selectively and non-covalently with any part of the small ribosomal subunit. 9/22 Gene Ontology MF GO:0043024 0.591799008551499 0.630886544458145 750 746.181818181818 757 0.0857027668195289 527 0.258132198251159 -0.230430872648285 -1 0.101372598580032 746 829 757 789 913 626 571 527 895 844 711 851 M18769 GO_RIBONUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. 824/1976 Gene Ontology MF GO:0032553 1.53722120755617e-06 9.12415168355918e-06 720 708.727272727273 758 1.53722227092927e-07 132 1.30645502669703 -1.0566297584864 -1 12.9256208382425 720 860 812 900 132 670 744 816 521 758 863 852 M18152 GO_RNA_POLYMERASE_II_CORE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_BINDING.html Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. 9/22 Gene Ontology MF GO:0000993 0.204108885661453 0.232977884377837 695 740.636363636364 759 0.0225706728749217 610 0.311684812125597 0.267174229527627 1 0.387120598582471 695 610 676 762 674 797 841 713 759 805 815 853 M18433 GO_TELOMERASE_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_RNA_BINDING.html Interacting selectively and non-covalently with the telomerase RNA template. 7/16 Gene Ontology MF GO:0070034 0.984481987880541 0.999998588329043 760 791.363636363636 759 0.340699190965105 647 0.12740804965979 -0.154013324253476 -1 5.70170074176034e-08 759 903 740 821 871 647 747 707 915 839 756 854 M19125 GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a chloride channel. 6/19 Gene Ontology MF GO:0017081 0.0179236657841489 0.0256052368344985 590 710.636363636364 759 0.00180698944830305 341 0.442286272172869 -0.471244288288705 -1 1.38197374025239 889 341 899 504 590 759 780 589 710 906 850 855 M18619 GO_OXYGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_BINDING.html Interacting selectively and non-covalently with oxygen (O2). 12/94 Gene Ontology MF GO:0019825 0.0739414924901896 0.0954083774066962 845 702.363636363636 760 0.00695911454710083 204 1.41927821185297 -1.08861813587471 -1 2.84306451476319 841 593 204 760 641 909 755 823 765 546 889 856 M18847 GO_FUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 4/11 Gene Ontology MF GO:0008417 0.71928346093558 0.758007770974494 565 740.727272727273 760 0.119302425872266 562 0.177516823645376 -0.32075372066733 -1 0.0419316775286244 728 885 828 787 760 631 562 565 875 877 650 857 M18587 GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any complex of RNA and protein. 64/123 Gene Ontology MF GO:0043021 0.996672637252087 0.999998588329043 765 767.181818181818 761 0.404699321861175 605 0.889959055535031 -0.993591766143445 -1 9.74778852056471e-07 734 891 605 858 898 673 656 761 877 762 724 858 M18300 GO_AMINOACYL_TRNA_EDITING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOACYL_TRNA_EDITING_ACTIVITY.html The hydrolysis of an incorrectly aminoacylated tRNA. 7/11 Gene Ontology MF GO:0002161 0.984615780328036 0.999998588329043 865 787.727272727273 762 0.341269841269841 704 0.548663710806455 -0.548663710806455 -1 5.64015712631797e-07 754 875 706 704 861 739 762 822 863 818 761 859 M18317 GO_SNAP_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNAP_RECEPTOR_ACTIVITY.html Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. 20/39 Gene Ontology MF GO:0005484 0.00171027127335709 0.0028870634339239 780 704.272727272727 764 0.000155600207299427 477 0.705641235913326 -0.705641235913326 -1 3.51789302094869 778 755 568 793 502 764 785 477 799 822 704 860 M18737 GO_ANION_ANION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_ANION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). 4/29 Gene Ontology MF GO:0015301 0.52340095663996 0.562211149253168 700 751.363636363636 764 0.0714285714285714 483 1.56555762087963 1.56555762087963 1 0.768646483395993 794 697 803 696 779 894 692 764 763 483 900 861 M19102 GO_ADENYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. 664/1625 Gene Ontology MF GO:0030554 1.3828987220203e-06 8.53870351851459e-06 895 718.272727272727 764 1.38289958260504e-07 128 1.26343812285167 -0.962127773024847 -1 12.5714590920765 715 847 892 892 128 699 765 758 534 764 907 862 M19219 GO_STRUCTURE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. 74/179 Gene Ontology MF GO:0043566 0.0839184282471183 0.101186047165595 830 702 764 0.00793650793650794 364 1.47963643861583 1.67022697823287 1 2.8898042872622 830 764 441 681 748 782 775 805 364 708 824 863 M18048 GO_UNFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with an unfolded protein. 55/120 Gene Ontology MF GO:0051082 0.667434366415499 0.70579266333593 790 687.545454545455 765 0.0952380952380952 455 0.828725998606559 -0.682020323802648 -1 0.246183157820484 639 799 570 804 789 527 455 770 787 765 658 864 M18442 GO_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 75/156 Gene Ontology MF GO:0004386 0.0839184282471183 0.101186047165595 800 742.727272727273 766 0.00793650793650794 586 1.18672024949635 -0.856828104725242 -1 2.31772423756251 772 811 586 799 718 665 716 902 637 766 798 865 M17873 GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. 208/483 Gene Ontology MF GO:0019787 0.0839184282471183 0.101186047165595 775 726.272727272727 767 0.00793650793650794 460 1.06437243948807 -1.01040049203063 -1 2.07877281107911 775 850 601 898 910 460 918 685 611 767 514 866 M18194 GO_RAN_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAN_GTPASE_BINDING.html Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. 12/38 Gene Ontology MF GO:0008536 0.360860333853153 0.397119027685288 700 746.181818181818 768 0.0398769671475986 496 0.66378805331283 0.754227721105753 1 0.522639953158009 768 684 496 842 696 795 699 698 818 809 903 867 M17938 GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 3/14 Gene Ontology MF GO:0099528 0.359333105394078 0.396499249448692 800 718.909090909091 770 0.0435478927949425 475 0.288005292578703 0.204369711134301 1 0.227147217322808 797 682 623 619 770 799 669 475 876 778 820 868 M18561 GO_LRR_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LRR_DOMAIN_BINDING.html Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. 12/25 Gene Ontology MF GO:0030275 0.597318307603006 0.636033383095794 775 736.272727272727 771 0.0793650793650794 499 0.345965647566628 -0.217677122433516 -1 0.133469680079947 920 751 499 743 834 611 545 772 771 852 801 869 M18355 GO_PROTEIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of proteins into, out of or within a cell, or between cells. 51/119 Gene Ontology MF GO:0008565 0.466738071388703 0.505911489497611 775 759.545454545455 774 0.0555555555555556 550 1.0537791992712 1.14904943935332 1 0.612174004057335 774 835 550 866 849 662 857 678 750 706 828 870 M18401 GO_FATTY_ACID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORTER_ACTIVITY.html Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 5/20 Gene Ontology MF GO:0015245 0.241773898497598 0.273257968817924 910 739.909090909091 775 0.0272978561482164 428 1.35928762038841 1.35928762038841 1 1.5034608296123 905 518 732 428 679 849 906 910 775 525 912 871 M18860 GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. 11/18 Gene Ontology MF GO:0034979 0.00566739419783486 0.0087045119566078 855 669.909090909091 775 0.000516549707067497 277 0.870465999444689 -0.819820820355015 -1 3.52059364267688 825 379 486 277 549 855 855 775 629 878 861 872 M18385 GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. 2/8 Gene Ontology MF GO:0003964 0.936125960789576 0.966594706988115 875 764.1 776.5 0.263354967609365 560 0.194725272999996 -0.272967840416282 -1 0.00564045850888422 873 763 730 NA 799 694 560 696 903 833 790 873 M17947 GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 5/21 Gene Ontology MF GO:0008308 0.360513219858426 0.397119027685288 805 751.727272727273 777 0.0437242183819019 618 0.623038318027675 -0.623038318027675 -1 0.490555248470246 803 761 625 618 701 800 835 777 839 781 729 874 M18827 GO_SNRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_BINDING.html Interacting selectively and non-covalently with a small nuclear RNA (snRNA). 18/42 Gene Ontology MF GO:0017069 0.0839184282471183 0.101186047165595 880 734.454545454545 779 0.00793650793650794 444 1.38673890232332 -0.881901158841867 -1 2.70837072656024 877 769 444 791 697 828 850 779 477 710 857 875 M18826 GO_HSP70_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP70_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. 19/36 Gene Ontology MF GO:0030544 0.949776431494504 0.978493076119758 625 746.363636363636 780 0.238095238095238 531 0.662702688954911 0.738863259855251 1 0.0122838217783564 625 802 531 860 809 738 605 744 840 876 780 876 M17962 GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. 6/15 Gene Ontology MF GO:0034483 0.147859119791321 0.171972680414685 790 733.727272727273 783 0.0158730158730159 471 0.681579794288844 -0.53387997405423 -1 1.02296361604693 788 471 626 579 788 713 863 915 657 783 888 877 M17970 GO_COMPLEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_BINDING.html Interacting selectively and non-covalently with any component or product of the complement cascade. 7/27 Gene Ontology MF GO:0001848 0.386086746459241 0.423360913876641 910 738.818181818182 784 0.0476190476190476 487 0.9392360253186 0.9392360253186 1 0.688276838645706 907 651 627 809 892 791 487 583 742 784 854 878 M18064 GO_LYSINE_ACETYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_ACETYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. 6/21 Gene Ontology MF GO:0070577 0.632427457617131 0.671087959639862 705 779.363636363636 784 0.0952380952380952 657 0.921065653530816 0.921065653530816 1 0.313208022417138 705 759 657 668 864 903 889 813 784 798 733 879 M18084 GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. 2/7 Gene Ontology MF GO:0004523 0.988699376649787 0.999998588329043 700 764.6 784 0.392315660394817 639 0.101591252571674 0.101591252571674 1 2.59454185852446e-08 698 792 662 NA 826 716 639 821 916 800 776 880 M17930 GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. 2/12 Gene Ontology MF GO:0043855 0.425243290158161 0.463535339982829 875 751.6 786.5 0.0596792807574045 493 0.749866069182958 -0.326389091416321 -1 0.491547333288421 796 660 621 NA 873 851 713 493 858 777 874 881 M18197 GO_PHOSPHATASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVATOR_ACTIVITY.html Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 5/11 Gene Ontology MF GO:0019211 0.00403627785724305 0.00639135220079795 905 708.090909090909 789 0.000404362784557658 423 0.711313788642169 -0.741565848784047 -1 3.06423060247408 902 480 685 423 538 821 868 855 618 810 789 882 M18043 GO_DNA_N_GLYCOSYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_N_GLYCOSYLASE_ACTIVITY.html Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. 7/17 Gene Ontology MF GO:0019104 0.990856081368011 0.999998588329043 820 783 793 0.374664282278776 648 0.242373704264994 -0.22535668658117 -1 1.95382953338143e-07 819 732 648 702 815 790 853 802 899 793 760 883 M19154 GO_DNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with a DNA polymerase. 7/16 Gene Ontology MF GO:0070182 0.761566178095549 0.797996450851828 800 806.818181818182 799 0.133563406866177 676 0.921065653530816 0.921065653530816 1 0.177196515064878 776 781 902 676 755 814 796 836 831 909 799 884 M18636 GO_FOUR_WAY_JUNCTION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOUR_WAY_JUNCTION_DNA_BINDING.html Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. 7/18 Gene Ontology MF GO:0000400 0.940634982288152 0.970161640925 805 799.636363636364 801 0.246031746031746 681 0.355466045920977 -0.405191923887527 -1 0.0091803060841291 801 681 785 722 911 792 774 820 845 860 805 885 M19000 GO_ANGIOTENSIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOTENSIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an angiotensin receptor. 7/21 Gene Ontology MF GO:0031701 0.900849582143098 0.934364842809076 640 752.727272727273 803 0.206349206349206 548 0.794407359393116 1.21141508368256 1 0.045979532548067 637 672 867 548 803 813 726 677 830 888 819 886 M19092 GO_PRE_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MRNA_BINDING.html Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. 16/40 Gene Ontology MF GO:0036002 0.920139993456083 0.952225864993922 900 792.636363636364 803 0.205284363112853 513 0.263513056543756 -0.258833339064021 -1 0.0109977826030583 897 803 513 755 774 839 811 799 874 900 754 887 M18370 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. 5/13 Gene Ontology MF GO:0016671 0.985013670034169 0.999998588329043 860 802.454545454545 806 0.342993707488945 675 0.175044605682527 -0.206076428599608 -1 1.14349583456225e-07 859 762 725 675 806 877 849 760 909 830 775 888 M18751 GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY.html Combining with a protein hormone to initiate a change in cell activity. 3/23 Gene Ontology MF GO:0016500 0.990511950668936 0.999998588329043 920 791.090909090909 808 0.372349768412799 532 0.0876840732227026 0.0876840732227026 1 9.20754993816872e-09 708 919 808 532 856 770 626 919 918 868 778 889 M18173 GO_GLYCINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_BINDING.html Interacting selectively and non-covalently with glycine, aminoethanoic acid. 5/15 Gene Ontology MF GO:0016594 0.727566008236836 0.765858956038775 815 796.818181818182 812 0.121936085666791 680 0.364242655968328 0.350135025280191 1 0.0828388107185479 813 821 680 812 752 858 707 746 854 807 915 890 M18283 GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES.html Catalysis of the hydrolysis of any acid anhydride. 387/890 Gene Ontology MF GO:0016817 0.0839184282471183 0.101186047165595 880 742.636363636364 813 0.00793650793650794 486 1.4533589869081 -1.29203064321738 -1 2.83848310244094 871 833 530 879 879 578 813 859 486 738 703 891 M18727 GO_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. 43/87 Gene Ontology MF GO:0008094 0.0839184282471183 0.101186047165595 705 773.454545454545 813 0.00793650793650794 525 2.39671055342465 2.39671055342465 1 4.6808961581322 702 853 525 769 813 856 919 844 633 759 835 892 M19070 GO_RIBOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BINDING.html Interacting selectively and non-covalently with any part of a ribosome. 30/56 Gene Ontology MF GO:0043022 0.985023615986936 0.999998588329043 880 803.909090909091 814 0.317460317460317 590 0.830718974237393 -1.082377024765 -1 9.0348095084149e-07 878 867 590 835 814 807 789 896 859 746 762 893 M17885 GO_OLFACTORY_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_RECEPTOR_ACTIVITY.html Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. 20/849 Gene Ontology MF GO:0004984 0.793850801076638 0.829934928398303 840 786.909090909091 817 0.133730792069102 434 1.17302356200135 1.17302356200135 1 0.186422499705661 840 776 434 795 756 910 817 870 850 717 891 894 M19039 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. 6/76 Gene Ontology MF GO:0016712 0.000283595117507028 0.000545831606917293 855 666.818181818182 817 2.83631315794584e-05 230 1.68338290802995 -1.08861813587471 -1 10.7828900131505 853 230 874 492 437 817 883 913 651 342 843 895 M17955 GO_DNA_SECONDARY_STRUCTURE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SECONDARY_STRUCTURE_BINDING.html Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. 11/27 Gene Ontology MF GO:0000217 0.955240661249004 0.981923361283892 855 787.545454545455 820 0.246031746031746 472 0.799881811106856 0.799881811106856 1 0.0124400645085689 852 731 472 750 880 866 820 778 842 782 890 896 M18327 GO_HISTONE_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a histone. 14/27 Gene Ontology MF GO:0032452 0.979118007801826 0.999998588329043 795 779.636363636364 822 0.296519613436064 548 0.195333114681818 -0.159937242684429 -1 1.38767647691534e-07 791 880 548 822 893 618 846 754 906 826 692 897 M19090 GO_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. 196/476 Gene Ontology MF GO:0016887 0.0839184282471183 0.101186047165595 915 757.818181818182 823 0.00793650793650794 468 1.82115099189775 2.31279902606679 1 3.55679938644735 911 888 490 800 885 641 823 846 468 757 827 898 M18431 GO_OXYGEN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORTER_ACTIVITY.html Enables the directed movement of oxygen into, out of or within a cell, or between cells. 5/17 Gene Ontology MF GO:0005344 0.997141953996692 0.999998588329043 840 790.818181818182 825 0.443318329900172 658 0.602807199894982 0.610006192986531 1 6.29179653192124e-07 725 658 739 741 876 825 666 911 883 838 837 899 M19122 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. 5/18 Gene Ontology MF GO:0015095 0.96712674294581 0.99303192356043 555 786 825 0.289303341402197 554 0.398730766684512 0.429373520667488 1 0.00237694908294195 554 798 898 825 858 701 574 908 868 905 757 900 M19216 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. 8/14 Gene Ontology MF GO:0097153 0.590312204896119 0.630031587592145 920 747.363636363636 827 0.0853702939615113 391 0.282679367227664 -0.236118754312415 -1 0.111339489529325 758 845 919 827 742 516 391 831 887 919 586 901 M18055 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY.html Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. 13/39 Gene Ontology MF GO:0061650 0.989865950533548 0.999998588329043 830 797.454545454545 828 0.341269841269841 437 0.353509196715591 -0.408512442740903 -1 3.29139139836435e-07 890 828 437 843 828 906 806 735 865 795 839 902 M18154 GO_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_BINDING.html Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. 91/227 Gene Ontology MF GO:0003729 0.0839184282471183 0.101186047165595 840 778.818181818182 833 0.00793650793650794 568 1.25147739747759 1.58207286409306 1 2.44419820455929 836 907 597 868 862 712 819 833 568 723 842 903 M18017 GO_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a substrate. 16/35 Gene Ontology MF GO:0032451 0.998866246116962 0.999998588329043 790 805 834 0.460204846852691 564 0.185368529700457 -0.147344208738162 -1 1.26774855310311e-07 887 871 564 834 867 730 878 787 907 788 742 904 M19065 GO_TBP_CLASS_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TBP_CLASS_PROTEIN_BINDING.html Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). 9/25 Gene Ontology MF GO:0017025 0.730293518508325 0.767851470888753 785 812.636363636364 837 0.122819157182137 570 0.214708910464277 -0.161519718780492 -1 0.0483550532358776 879 858 886 782 837 726 812 570 912 896 781 905 M18250 GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY.html Functions in chain elongation during polypeptide synthesis at the ribosome. 11/20 Gene Ontology MF GO:0003746 0.999801755095825 0.999998588329043 910 811.272727272727 841 0.539338409235024 520 0.18812047092651 -0.171679735649618 -1 1.30086931009511e-07 908 915 520 768 841 816 710 876 904 815 851 906 M18482 GO_TELOMERIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERIC_DNA_BINDING.html Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. 18/38 Gene Ontology MF GO:0042162 0.988214537583422 0.999998588329043 900 796.909090909091 842 0.332167000117299 538 0.200309741391755 -0.252823874106796 -1 1.44757224879422e-07 851 899 538 798 904 707 900 700 908 842 719 907 M18985 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. 9/17 Gene Ontology MF GO:0005337 0.000302097519876489 0.000575423847383788 875 672.545454545455 848 3.02138596045927e-05 155 0.728848199074853 -0.57655520715211 -1 4.63582161721045 872 155 866 372 440 889 874 891 555 636 848 908 M18677 GO_RAL_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAL_GTPASE_BINDING.html Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. 8/21 Gene Ontology MF GO:0017160 0.952012952007826 0.979700129582997 750 835.909090909091 849 0.261904761904762 750 0.25611276715795 -0.186533969882778 -1 0.00447804313065309 750 883 796 819 886 905 756 829 849 864 858 909 M18208 GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. 11/29 Gene Ontology MF GO:0005487 0.99996943737225 0.999998588329043 915 827.727272727273 850 0.611346314676009 565 0.13249493693664 0.126338871627638 1 6.31392877827226e-08 807 914 565 756 850 918 790 873 910 811 911 910 M18639 GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. 7/11 Gene Ontology MF GO:0051766 0.351951243757462 0.389645179611149 875 823.363636363636 852 0.0424515267787072 700 0.685385583564363 -0.685385583564363 -1 0.550747077734912 860 753 788 792 700 872 852 872 823 861 884 911 M19181 GO_ODORANT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODORANT_BINDING.html Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell. 6/293 Gene Ontology MF GO:0005549 0.999978572124981 0.999998588329043 910 847.272727272727 862 0.658730158730159 737 0.205577132185241 -0.146104293053686 -1 1.51096748732668e-07 741 846 910 737 874 819 804 909 902 916 862 912 M18691 GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. 7/13 Gene Ontology MF GO:0043142 0.99866516337188 0.999998588329043 800 849.545454545455 864 0.484126984126984 738 0.198865072658875 -0.200234973041812 -1 1.43018505985912e-07 916 859 799 738 844 869 903 798 890 865 864 913 M17939 GO_METHYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 28/67 Gene Ontology MF GO:0035064 0.993240511078093 0.999998588329043 915 808.454545454545 865 0.365079365079365 554 0.819306326802198 -0.517104119318463 -1 8.89745355082468e-07 766 911 554 872 915 865 698 780 870 742 920 914 M19057 GO_NEUROPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_BINDING.html Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). 2/38 Gene Ontology MF GO:0042923 0.869943105741072 0.904347635346651 840 828.7 867 0.202794336345956 506 0.214934561659429 -0.212899582330126 -1 0.0184236808062003 838 904 882 NA 852 810 506 889 917 895 794 915 M18629 GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. 2/22 Gene Ontology MF GO:0015106 0.99264520054825 0.999998588329043 830 847.4 868.5 0.420634920634921 699 0.390051509410326 -0.256731527362081 -1 3.73119332699202e-07 828 699 783 NA 902 908 801 898 879 858 918 916 M19007 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. 5/10 Gene Ontology MF GO:0046933 0.993965665947939 0.999998588329043 920 814.363636363636 869 0.400122000024393 643 0.0800336936519983 -0.0800336936519983 -1 0 764 918 869 754 912 671 643 878 919 890 740 917 M19055 GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY.html Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. 9/40 Gene Ontology MF GO:0008329 0.99882838573881 0.999998588329043 885 853.727272727273 873 0.490811642607287 753 0.346736526101974 0.255594137482839 1 3.20987949125788e-07 884 831 881 753 835 873 880 794 900 894 866 918 M18520 GO_SUMO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_BINDING.html Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. 6/17 Gene Ontology MF GO:0032183 0.999996197853836 0.999998588329043 915 847.545454545455 876 0.712920037507935 726 0.177722924277996 -0.15135829687552 -1 1.17573051258076e-07 795 876 760 726 881 831 911 893 911 846 893 919 M18879 GO_PEPTIDOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDOGLYCAN_BINDING.html Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. 4/26 Gene Ontology MF GO:0042834 0.999998588329043 0.999998588329043 880 851.545454545455 877 0.74 678 0.143014785179672 0.0885177383241675 1 7.58003625888126e-08 835 877 837 678 891 899 809 840 913 880 908 920 M19080 GO_C_C_CHEMOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_C_CHEMOKINE_RECEPTOR_ACTIVITY.html Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. 2/13 Gene Ontology MF GO:0016493 0.847044419676867 0.882537787205796 920 849.8 890 0.18829887601951 494 0.0495236656822731 -0.00199382190676012 -1 0.00527571338274786 808 920 890 NA 890 888 494 916 920 899 873