Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance 1 M16984 GO_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX.html A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants). 172/559 Gene Ontology CC GO:0031012 3.81248016577895e-49 2.20361353582023e-46 5 29.8484848484848 15 1.15529701993303e-50 1 2.10511223802589 2.25756276986331 1 100 2 M17343 GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX.html A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. 133/408 Gene Ontology CC GO:0005578 6.17307819715883e-47 1.7840195989789e-44 5 27.1212121212121 18 1.87062975671481e-48 1 2.10942781373113 2.23016293958606 1 88.7887127229254 3 M17310 GO_COMPLEX_OF_COLLAGEN_TRIMERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEX_OF_COLLAGEN_TRIMERS.html A complex of collagen trimers such as a fibril or collagen network. 12/30 Gene Ontology CC GO:0098644 2.61319749886959e-09 4.72008798233321e-08 50 51 23 7.91878030963796e-11 4 2.45059060225421 2.45059060225421 1 17.6939570461838 4 M17128 GO_SITE_OF_POLARIZED_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_POLARIZED_GROWTH.html Any part of a cell where non-isotropic growth takes place. 108/272 Gene Ontology CC GO:0030427 5.29390401661512e-11 1.17687558523213e-09 20 110.454545454545 24 1.60421333840939e-12 5 1.75926837139106 1.95643652795848 1 14.0645857108327 5 M17365 GO_BANDED_COLLAGEN_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BANDED_COLLAGEN_FIBRIL.html A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). 12/23 Gene Ontology CC GO:0098643 2.61319749886959e-09 4.72008798233321e-08 50 51.7878787878788 24 7.91878030963796e-11 5 2.45059060225421 2.45059060225421 1 17.6939570461838 6 M17676 GO_NEUROMUSCULAR_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION.html The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. 55/122 Gene Ontology CC GO:0031594 6.85918918853826e-09 1.1327461002786e-07 10 42.7575757575758 26 2.07854218525747e-10 4 1.88101731543051 2.02845199841049 1 11.9400188402162 7 M17697 GO_MICROBODY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_PART.html Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 54/112 Gene Ontology CC GO:0044438 1.45288538574013e-08 2.09941938239448e-07 20 125.545454545455 28 4.40268301810509e-10 1 0.971297682795489 -0.959868033391008 -1 6.15905433622314 8 M17408 GO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE.html The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. 361/1081 Gene Ontology CC GO:0045202 6.57844007372618e-11 1.35797798664776e-09 20 102.212121212121 31 1.99346668907152e-12 2 1.5879120937307 1.73621276700892 1 12.8177111064105 9 M17629 GO_NEURON_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a neuron projection. 18/74 Gene Ontology CC GO:0032589 1.48000312126916e-07 9.00465056940603e-07 15 142.060606060606 34 4.4848582650631e-09 3 1.86128247256943 1.2780837082154 0.333333333333333 11.0182237337821 10 M17362 GO_ENDOPLASMIC_RETICULUM_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_LUMEN.html The volume enclosed by the membranes of the endoplasmic reticulum. 95/258 Gene Ontology CC GO:0005788 6.80620559070814e-13 2.62265788761953e-11 30 61.8484848484849 34 2.0624865426395e-14 5 2.03779912862334 2.2671894882489 1 19.6979312782306 11 M17494 GO_DENDRITE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MEMBRANE.html The portion of the plasma membrane surrounding a dendrite. 12/37 Gene Ontology CC GO:0032590 1.24425140677405e-08 1.89257187661948e-07 5 158.212121212121 37 3.77045883115238e-10 1 1.75241822854218 1.11250798903628 0.333333333333333 11.2812661221235 12 M17302 GO_BASEMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE.html A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. 53/132 Gene Ontology CC GO:0005604 2.6450557571787e-19 1.38985657059026e-17 15 47.5151515151515 38 8.01532047629912e-21 1 2.06859607327965 2.15410585131842 1 29.4086385383175 13 M17077 GO_BASAL_LAMINA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_LAMINA.html A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. 18/46 Gene Ontology CC GO:0005605 9.4058683256108e-15 3.88327992300218e-13 75 44.9393939393939 43 2.85026312897298e-16 2 2.2151332532428 2.3519489320094 1 23.9028039444911 14 M17398 GO_EXTRACELLULAR_MATRIX_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_COMPONENT.html Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). 65/171 Gene Ontology CC GO:0044420 6.60136011361868e-24 4.23954016185733e-22 45 41.7575757575758 43 2.00041215564203e-25 3 2.13469013123822 2.24683629302147 1 37.833242489803 15 M17016 GO_FILOPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a filopodium. 11/22 Gene Ontology CC GO:0031527 1.07141546395416e-07 7.46118238753619e-07 5 169.545454545455 47 3.24671369579219e-09 2 2.19390774267521 2.19390774267521 1 13.1580606707102 16 M17334 GO_LEADING_EDGE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEADING_EDGE_MEMBRANE.html The portion of the plasma membrane surrounding the leading edge of a motile cell. 82/233 Gene Ontology CC GO:0031256 2.65110395921346e-08 3.19237101755287e-07 35 88.2121212121212 47 8.0336484645161e-10 6 1.60075450925385 1.7791351721123 1 9.41794186387179 17 M17511 GO_MEMBRANE_MICRODOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_MICRODOMAIN.html A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. 188/491 Gene Ontology CC GO:0098857 2.17667107175034e-11 5.99102799748427e-10 75 61.1818181818182 47 6.59597294476758e-13 6 1.62114591220203 1.81707354782146 1 17.8077368550999 18 M17227 GO_ACTIN_FILAMENT_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE.html An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. 46/106 Gene Ontology CC GO:0032432 3.75661067328464e-07 1.59154046816245e-06 20 143.272727272727 48 1.13836707803303e-08 19 2.10745606435434 2.33923781154837 1 11.6509873913185 19 M17195 GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION.html Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. 17/43 Gene Ontology CC GO:0098636 7.61489187318633e-08 6.47265809220838e-07 90 100.424242424242 50 2.30754307707071e-09 3 2.08315247520589 2.41262078621512 1 12.5692581478328 20 M17263 GO_NEURON_SPINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_SPINE.html A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. 76/235 Gene Ontology CC GO:0044309 2.84530210620308e-07 1.38200388015578e-06 25 122.787878787879 52 8.62212878401231e-09 1 1.75687287088763 1.95701243624696 1 10.9248645399369