Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M16984 GO_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX.html A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants). 172/559 Gene Ontology CC GO:0031012 1.91622045464785e-20 1.10757542278646e-17 5 17.6363636363636 15 1.74201859513441e-21 1 1.527119794045 1.57772278131979 1 100 1 15 1 12 75 23 5 16 20 2 24 2 M17733 GO_GOLGI_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LUMEN.html The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. 35/156 Gene Ontology CC GO:0005796 1.73984255601362e-07 1.00562899737587e-05 5 80.3636363636364 15 1.58167517600628e-08 1 1.69134118326295 1.83027731417118 1 32.6439331915698 135 2 8 1 123 326 99 15 5 5 165 3 M17343 GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX.html A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. 133/408 Gene Ontology CC GO:0005578 3.04858261896381e-16 8.8104037688054e-14 5 22.7272727272727 18 2.77143874451255e-17 2 1.50742065644797 1.56966747757313 1 76.0019132281003 2 8 2 21 76 49 14 18 19 3 38 4 M17310 GO_COMPLEX_OF_COLLAGEN_TRIMERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEX_OF_COLLAGEN_TRIMERS.html A complex of collagen trimers such as a fibril or collagen network. 12/30 Gene Ontology CC GO:0098644 1.55056478837665e-05 0.000471698130358792 25 24.9090909090909 21 1.40961428808987e-06 4 1.46778240338295 1.46778240338295 1 18.8556201214471 4 28 21 23 19 28 9 11 91 25 15 5 M17365 GO_BANDED_COLLAGEN_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BANDED_COLLAGEN_FIBRIL.html A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). 12/23 Gene Ontology CC GO:0098643 1.55056478837665e-05 0.000471698130358792 30 25.7272727272727 22 1.40961428808987e-06 5 1.46778240338295 1.46778240338295 1 18.8556201214471 5 29 22 24 20 29 10 10 92 26 16 6 M17766 GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 21/45 Gene Ontology CC GO:0046658 2.73322465393183e-05 0.00068687123911852 25 33.6363636363636 22 2.4847805558345e-06 3 1.14932796222727 1.23402891782666 1 14.0402011301225 22 24 19 3 86 73 88 3 12 12 28 7 M17023 GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 10/21 Gene Ontology CC GO:0031362 0.000193178327832265 0.0036018410802274 5 54.3636363636364 31 1.7563208416757e-05 1 0.936639265818195 0.957302400615691 1 8.83880164813219 52 3 31 8 1 156 83 17 16 147 84 8 M17827 GO_ANCHORED_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 56/186 Gene Ontology CC GO:0031225 6.7150618764249e-07 3.52845978597599e-05 10 44 32 6.10460356914971e-08 8 1.24133892729626 1.33159942503122 1 21.3451417113538 14 9 9 58 196 72 41 12 32 8 33 9 M17474 GO_EXTRACELLULAR_SPACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_SPACE.html That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. 587/2139 Gene Ontology CC GO:0005615 8.98402745056012e-14 1.29819196660594e-11 15 82.3636363636364 37 8.98402745056051e-15 1 1.476907110456 1.52844257259391 1 62.0956148553864 12 14 514 11 78 114 37 33 38 1 54 10 M17011 GO_INFLAMMASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMASOME_COMPLEX.html A cytosolic protein complex that is capable of activating caspase-1. 4/12 Gene Ontology CC GO:0061702 0.00048000771913887 0.00711396055544275 5 89.1818181818182 40 4.80111434004779e-05 3 1.53150662091758 1.53150662091758 1 12.7040931135103 40 138 435 130 3 18 8 4 119 82 4 11 M17136 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. 12/26 Gene Ontology CC GO:0033177 0.00186000537990102 0.0206746751842844 10 104.454545454545 40 0.00016923452711929 2 0.801505046067566 -0.801505046067566 -1 5.21442143517578 46 135 387 40 12 10 7 19 108 383 2 12 M17491 GO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE.html The external part of the cell wall and/or plasma membrane. 354/1190 Gene Ontology CC GO:0009986 6.80000202795597e-16 1.31013372405285e-13 5 48 40 6.1818200254145e-17 2 1.40979356592352 1.43609910047858 1 70.1414820937479 19 73 3 2 114 139 40 28 61 7 42 13 M17398 GO_EXTRACELLULAR_MATRIX_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_COMPONENT.html Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). 65/171 Gene Ontology CC GO:0044420 3.11729754553212e-06 0.000120119865421171 45 54.9090909090909 44 2.83391087509666e-07 3 1.4558227844444 1.4558227844444 1 22.0419643837444 3 44 13 83 70 39 12 35 158 103 44 14 M17511 GO_MEMBRANE_MICRODOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_MICRODOMAIN.html A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. 188/491 Gene Ontology CC GO:0098857 1.21847087775146e-06 5.86896806116952e-05 20 53.2727272727273 47 1.10770141145687e-07 6 1.4245493539249 1.43431906519222 1 23.2797630387028 20 65 10 16 62 147 86 25 102 6 47 15 M17559 GO_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_COMPLEX.html Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 124/450 Gene Ontology CC GO:0043235 0.00877633253621545 0.0589851186736341 30 76.5454545454545 47 0.000801049112874055 20 1.43324345521909 1.50180293543428 1 6.80418159844839 21 158 42 118 194 105 82 20 47 29 26 16 M17676 GO_NEUROMUSCULAR_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION.html The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. 55/122 Gene Ontology CC GO:0031594 0.00435022827854382 0.0365512216734406 50 65.1818181818182 47 0.000396259473320412 15 1.36872034350485 1.36872034350485 1 7.59651125203527 15 69 46 47 141 77 46 26 171 30 49 17 M17446 GO_VACUOLAR_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_LUMEN.html The volume enclosed within the vacuolar membrane. 75/197 Gene Ontology CC GO:0005775 0.00473222839214761 0.0385243381783285 30 115.454545454545 52 0.000431130748714453 8 1.4174674828401 1.48137593342073 1 7.74206633915275 132 27 52 25 8 405 198 99 30 17 277 18 M17845 GO_COLLAGEN_TRIMER http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_TRIMER.html A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. 29/89 Gene Ontology CC GO:0005581 1.97234208552765e-09 1.90002287572497e-07 25 54.5454545454545 52 1.79303826117808e-10 5 1.43894190054246 1.43894190054246 1 37.3513054561197 6 23 5 52 58 164 22 57 95 19 99 19 M17077 GO_BASAL_LAMINA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_LAMINA.html A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. 18/46 Gene Ontology CC GO:0005605 4.5136606826058e-05 0.00104355834981846 20 47.5454545454545 53 4.10341208219519e-06 10 1.46778240338295 1.46778240338295 1 16.9007936703778 10 36 20 70 55 66 19 53 94 43 57 20 M17166 GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 599/2062 Gene Ontology CC GO:0031226 1.11245769863869e-07 7.14445055347959e-06 55 107.909090909091 54 1.11245775432899e-08 4 1.41603633760683 1.49235718019317 1 28.1423174438233 17 55 459 51 249 138 54 45 51 4 64 21 M17302 GO_BASEMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE.html A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. 53/132 Gene Ontology CC GO:0005604 6.73971834131605e-05 0.0014982912312618 60 77.4545454545455 59 6.12720438364104e-06 8 1.35094468212991 1.35094468212991 1 14.7359247361381 8 68 23 160 105 56 13 54 164 142 59 22 M17199 GO_HOPS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOPS_COMPLEX.html A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. 12/16 Gene Ontology CC GO:0030897 0.00175361440715813 0.0202717825467479 30 112.636363636364 61 0.000159546706417624 1 0.309498293318979 -0.32686137570796 -1 2.02374590118601 28 102 341 81 115 43 1 61 26 395 46 23 M17362 GO_ENDOPLASMIC_RETICULUM_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_LUMEN.html The volume enclosed by the membranes of the endoplasmic reticulum. 95/258 Gene Ontology CC GO:0005788 0.000214535374052236 0.00387504519381852 120 119.909090909091 62 1.95051179597573e-05 10 1.49797575472757 1.54931195896039 1 13.9522836765256 117 18 25 42 48 568 175 62 98 10 156 24 M17230 GO_CILIARY_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TIP.html Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. 25/63 Gene Ontology CC GO:0097542 0.000125271020830459 0.00268172777925946 5 147.727272727273 63 1.13889231366439e-05 1 0.682640524240463 -0.682640524240463 -1 6.77963088263226 23 45 333 63 365 1 4 109 271 410 1 25 M17167 GO_PORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX.html Any small opening in a membrane that allows the passage of gases and/or liquids. 11/21 Gene Ontology CC GO:0046930 0.000153072418152306 0.00305089164455286 65 67.5454545454545 64 1.39166427017748e-05 1 2.24458518468169 2.24458518468169 1 21.8065068147721 65 71 158 60 134 64 17 1 14 156 3 26 M17760 GO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM.html A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. 237/685 Gene Ontology CC GO:0005929 0.000691732934585721 0.00975174722415968 150 119.636363636364 69 6.29045934412246e-05 3 1.16800381550241 -0.841223861183275 -1 9.07092500127432 149 7 236 48 306 3 69 265 64 155 14 27 M17593 GO_CIS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. 28/52 Gene Ontology CC GO:0005801 0.00436338113402664 0.0365512216734406 55 124.636363636364 71 0.000397459943137015 7 0.913174176287696 -0.828778688518626 -1 5.06819229764284 53 34 326 71 79 7 29 411 100 249 12 28 M17595 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE.html A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. 25/42 Gene Ontology CC GO:0030140 0.021632642764119 0.101345082801036 75 106.545454545455 73 0.00198621200873745 22 1.02237527887538 -1.02237527887538 -1 3.92550896718552 73 136 300 50 46 36 74 22 286 110 39 29 M17743 GO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM.html The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). 834/2134 Gene Ontology CC GO:0005783 0.0107400144696248 0.065344509088875 565 246.181818181818 73 0.00107922768707931 4 1.24515715686454 1.37610890097577 1 5.69742905695184 563 4 564 22 73 59 562 542 58 15 246 30 M17005 GO_LYSOSOMAL_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_LUMEN.html The volume enclosed within the lysosomal membrane. 56/120 Gene Ontology CC GO:0043202 0.0090746876443023 0.0589997948646917 35 156.181818181818 75 0.00082839427640162 15 1.52401878093994 1.60712156583901 1 7.23449255966366 192 75 50 34 15 514 308 138 36 31 325 31 M17035 GO_BASOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASOLATERAL_PLASMA_MEMBRANE.html The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 114/324 Gene Ontology CC GO:0016323 0.000135671177882692 0.00280064074343557 30 121.727272727273 75 1.23345041156921e-05 24 1.31398753019678 1.41601466007398 1 12.9542214363324 30 169 24 142 490 106 75 41 175 39 48 32 M17564 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. 49/112 Gene Ontology CC GO:0033116 0.0013932757983153 0.0167773627380467 20 143.272727272727 75 0.000126741723001301 4 1.19168785990109 1.35897149268293 1 8.17036613593506 195 20 75 13 4 566 162 139 17 45 340 33 M17680 GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. 104/420 Gene Ontology CC GO:0009897 2.22653778376766e-08 1.83848405573958e-06 145 96.3636363636364 75 2.02412527845602e-09 6 1.32197552098313 1.36941924393497 1 29.2826774458072 16 142 6 191 207 127 49 36 145 66 75 34 M17630 GO_INTEGRATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRATOR_COMPLEX.html A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. 9/14 Gene Ontology CC GO:0032039 0.00373959742610975 0.0343093224173244 105 147.545454545455 79 0.00037459054362154 7 0.332679537851771 -0.341390914524447 -1 1.88171811239438 124 12 546 101 33 101 60 7 33 527 79 35 M17142 GO_APICAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PART_OF_CELL.html The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. 212/594 Gene Ontology CC GO:0045177 1.55858560830523e-06 6.4347320114316e-05 15 100 80 1.41689701134835e-07 12 1.51621198234019 1.5632361581056 1 24.5436577224077 13 121 12 127 308 112 55 59 133 80 80 36 M17606 GO_APICAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the apical end of the cell. 170/492 Gene Ontology CC GO:0016324 1.39003940939035e-06 6.18032906636632e-05 15 95.9090909090909 82 1.26367298878927e-07 11 1.37945481988568 1.40853239831327 1 22.4232344203572 11 83 11 126 286 82 32 75 191 90 68 37 M17616 GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT.html A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. 7/15 Gene Ontology CC GO:0044322 0.00579999605706465 0.0435376327400438 15 192.818181818182 82 0.000581518987817846 11 0.269042970014942 -0.269042970014942 -1 1.41428181071495 72 148 544 238 82 15 11 23 430 523 35 38 M17628 GO_PLASMA_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_REGION.html A membrane that is a (regional) part of the plasma membrane. 437/1317 Gene Ontology CC GO:0098590 2.07275594236111e-10 2.39610586936945e-08 35 106.909090909091 83 1.88432358414218e-11 4 1.31034040332866 1.37875111550334 1 38.5638429072849 35 42 4 59 208 295 134 83 136 18 162 39 M17664 GO_CELL_PROJECTION_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_PART.html Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. 498/1408 Gene Ontology CC GO:0044463 0.0155689495899052 0.0840686565746964 510 189.363636363636 84 0.00142547563306525 37 1.22967368116309 1.42157853870584 1 5.10692150519773 507 41 49 84 188 37 426 397 75 65 214 40 M17295 GO_CILIARY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PART.html Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 146/415 Gene Ontology CC GO:0044441 0.00223994630327101 0.0239757215424194 120 127 86 0.000203839107031211 5 1.30380962776731 -0.902721050985711 -1 8.15837094938408 119 50 241 86 402 5 76 161 54 181 22 41 M17447 GO_LAMELLIPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a lamellipodium. 19/37 Gene Ontology CC GO:0031258 0.0541871687840508 0.17497309249822 145 96.5454545454545 88 0.0050517949402702 9 1.33523410422378 1.33523410422378 1 3.90375745246882 142 46 112 9 97 324 28 55 24 88 137 42 M17746 GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. 7/34 Gene Ontology CC GO:0034361 0.0391950106263386 0.142241798862483 35 142.909090909091 88 0.0039903986449626 31 1.90919498657043 1.90919498657043 1 6.24500481178412 31 88 566 133 50 180 65 67 205 115 72 43 M17729 GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. 13/29 Gene Ontology CC GO:0031233 0.000730438117208467 0.010052219803488 50 89.5454545454545 89 6.64255225551976e-05 14 0.936639265818195 0.957302400615691 1 7.22643238005965 56 47 30 14 102 188 89 46 96 175 142 44 M17840 GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE.html A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood. 7/34 Gene Ontology CC GO:0034385 0.0391950106263386 0.142241798862483 70 144.909090909091 89 0.0039903986449626 32 1.90919498657043 1.90919498657043 1 6.24500481178412 32 89 578 134 51 181 66 68 206 116 73 45 M17831 GO_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE.html A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. 252/725 Gene Ontology CC GO:0030425 0.0276770850353765 0.1193832473914 60 210.818181818182 90 0.00254832137972484 37 1.39109600780712 1.51285509678778 1 4.95905001828414 526 59 56 37 90 116 392 568 78 61 336 46 M17623 GO_ACROSOMAL_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_VESICLE.html A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. 44/154 Gene Ontology CC GO:0001669 0.004899815760563 0.0386101821814285 365 200.636363636364 92 0.000446432974984024 10 1.98577082557803 1.98577082557803 1 10.8386692407912 364 92 85 44 10 511 423 66 39 199 374 47 M17141 GO_CELL_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a cell surface projection. 160/464 Gene Ontology CC GO:0031253 0.000447717671445189 0.0068893716941348 320 194.363636363636 93 4.07098919595916e-05 5 1.28062066665273 1.44461410597693 1 10.6918574747895 316 16 28 5 93 450 346 325 56 44 459 48 M17601 GO_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL.html Extracellular matrix material consisting of polysaccharides and protein. 5/23 Gene Ontology CC GO:0043205 0.0184712126510731 0.0947430395272726 65 135.272727272727 93 0.00186265667215859 29 1.98021329601685 1.98021329601685 1 7.82695414862768 63 167 542 131 29 107 63 88 154 93 51 49 M17092 GO_GLYCOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_COMPLEX.html A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. 9/23 Gene Ontology CC GO:0090665 0.0416569826912961 0.147716171751958 40 169.909090909091 94 0.00424591146682468 4 1.65887207235777 1.65887207235777 1 5.32112187342598 36 314 448 94 461 237 87 34 4 52 102 50 M17506 GO_DNA_PACKAGING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING_COMPLEX.html A protein complex that plays a role in the process of DNA packaging. 50/109 Gene Ontology CC GO:0044815 4.02077848435448e-05 0.000968337484982038 95 115.818181818182 95 3.65531997368294e-06 7 1.2451718004747 -1.2451718004747 -1 14.4937817802387 7 127 38 284 154 95 94 38 214 132 91 51 M17135 GO_CELL_PROJECTION_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_CYTOPLASM.html All of the contents of a cell projection, excluding the plasma membrane surrounding the projection. 35/73 Gene Ontology CC GO:0032838 0.0428527198075496 0.148316599094393 45 189.181818181818 96 0.00397372030192213 35 0.873248762656407 -0.873248762656407 -1 2.7951565354609 92 454 334 389 96 35 51 42 282 261 45 52 M17632 GO_SARCOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOLEMMA.html The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. 69/199 Gene Ontology CC GO:0042383 0.00622559461715544 0.0461332524194339 25 122.636363636364 96 0.000567571092314717 25 1.26649088867367 1.26649088867367 1 6.53456978038039 25 186 39 165 270 136 96 30 256 68 78 53 M17045 GO_SECRETORY_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE.html A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. 182/584 Gene Ontology CC GO:0030141 3.57931785548842e-06 0.000129302857529519 145 100.090909090909 97 3.25393061719835e-07 14 1.49347292432624 1.5736835818353 1 22.4274774212861 24 156 14 150 59 177 97 65 144 72 143 54 M17384 GO_CELL_SUBSTRATE_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION.html A cell junction that forms a connection between a cell and the extracellular matrix. 303/642 Gene Ontology CC GO:0030055 0.0748513025326372 0.198790375109977 120 120.363636363636 97 0.00704784664828194 29 1.27702876159869 1.36501570581997 1 3.46023968066279 97 119 118 29 77 417 148 69 65 76 109 55 M17575 GO_AUTOPHAGOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_MEMBRANE.html The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. 19/34 Gene Ontology CC GO:0000421 0.0196648432995059 0.0956504690311516 105 113.636363636364 101 0.00180389548958438 18 0.913113283997645 -0.913113283997645 -1 3.59455577313927 43 86 305 104 206 20 21 101 134 212 18 56 M17052 GO_AUTOPHAGOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME.html A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. 51/88 Gene Ontology CC GO:0005776 0.0042270117618977 0.0365512216734406 85 150.636363636364 102 0.000385014120466244 7 0.942676214734006 -0.856451831471855 -1 5.23193105424939 94 99 327 102 7 85 81 391 125 226 120 57 M17084 GO_NEURON_PROJECTION_TERMINUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_TERMINUS.html The specialized, terminal region of a neuron projection such as an axon or a dendrite. 80/226 Gene Ontology CC GO:0044306 0.015595015071035 0.0840686565746964 45 138.818181818182 103 0.00142787929544421 22 1.53413690123984 1.63477743457066 1 6.3713787280752 173 56 68 103 22 431 160 210 42 41 221 58 M17334 GO_LEADING_EDGE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEADING_EDGE_MEMBRANE.html The portion of the plasma membrane surrounding the leading edge of a motile cell. 82/233 Gene Ontology CC GO:0031256 0.035100118931867 0.136160192903484 195 162.909090909091 105 0.00324299674525707 10 1.14355729192904 1.25050669793567 1 3.82440354097503 191 98 67 10 43 527 177 257 105 64 253 59 M16998 GO_ER_TO_GOLGI_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE.html A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. 52/130 Gene Ontology CC GO:0030134 0.05339564752983 0.174365447865772 70 169.363636363636 106 0.0049761290719098 34 1.30598535922607 1.30598535922607 1 3.82586460405602 177 106 69 69 68 561 269 121 34 48 341 60 M17685 GO_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_CILIUM.html A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors. 108/307 Gene Ontology CC GO:0072372 0.0114655940128678 0.0683207560766761 110 193.272727272727 106 0.00104779892205242 11 1.1997710365687 -0.659898063103771 -1 5.40012824812621 178 26 242 78 574 11 106 531 49 225 106 61 M16982 GO_RNA_CAP_BINDING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING_COMPLEX.html Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. 10/20 Gene Ontology CC GO:0034518 0.000452934471240696 0.0068893716941348 110 140.909090909091 109 4.11843407237498e-05 2 0.316508777344822 -0.328533547146315 -1 2.64252078650899 109 116 290 177 2 41 59 39 301 333 83 62 M17119 GO_SECRETORY_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_VESICLE.html A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. 230/739 Gene Ontology CC GO:0099503 7.33385055604399e-06 0.000249350918905496 130 150.727272727273 109 6.66715909459165e-07 15 1.43723029336028 1.57868680687438 1 19.9998369977134 126 91 15 66 32 458 261 115 109 75 310 63 M17701 GO_PERICENTRIOLAR_MATERIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIOLAR_MATERIAL.html A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. 11/25 Gene Ontology CC GO:0000242 0.00293351888096449 0.0292340329861633 15 135.272727272727 109 0.000267039800420532 5 0.374180839743717 -0.374180839743717 -1 2.21692729893159 26 109 272 164 159 12 20 5 166 542 13 64 M17263 GO_NEURON_SPINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_SPINE.html A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. 76/235 Gene Ontology CC GO:0044309 0.00109945016496701 0.014121826563354 515 246.272727272727 110 1e-04 1 1.24900406864519 1.29798707890813 1 8.92430173966713 468 1 44 7 85 371 513 561 110 34 515 65 M17571 GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX.html RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 9/21 Gene Ontology CC GO:0005666 0.0300797424349819 0.123341053355889 85 177.454545454545 111 0.00304948280888414 40 1.07643464219997 1.07643464219997 1 3.77844547340566 81 313 538 326 40 168 52 86 97 140 111 66 M17775 GO_SYNAPSE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_PART.html Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 288/866 Gene Ontology CC GO:0044456 0.0839184282471183 0.198790375109977 110 253.363636363636 111 0.00793650793650794 78 1.27954315073388 1.38534144898987 1 3.46705267449231 396 78 90 106 111 249 547 497 83 109 521 67 M17839 GO_PRIMARY_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_LYSOSOME.html A lysosome before it has fused with a vesicle or vacuole. 12/68 Gene Ontology CC GO:0005766 0.00466671640522533 0.0385243381783285 10 149.545454545455 111 0.00042514955492901 6 2.06322935667965 2.06322935667965 1 11.2691534369912 59 571 218 176 214 79 111 9 35 167 6 68 M17678 GO_SOMATODENDRITIC_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATODENDRITIC_COMPARTMENT.html The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. 373/1027 Gene Ontology CC GO:0036477 2.10402603525515e-05 0.000579108118274989 385 217.545454545455 112 1.91276923446679e-06 17 1.38840638369481 1.52984570037787 1 17.3581962303507 383 112 17 72 108 231 537 334 66 22 511 69 M17792 GO_NEURONAL_CELL_BODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_CELL_BODY_MEMBRANE.html The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. 12/44 Gene Ontology CC GO:0032809 0.0359389819429128 0.137567758695388 115 122.727272727273 112 0.00332180597533707 44 1.13187952096227 1.19079054864899 1 3.76582497568501 95 221 116 112 44 262 114 47 99 62 178 70 M17198 GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE.html The membrane surrounding the outer segment of a vertebrate photoreceptor. 6/19 Gene Ontology CC GO:0042622 0.000222301616856016 0.00389364650129629 5 159.363636363636 113 2.22323858091432e-05 2 3.13200079211126 3.13200079211126 1 29.1465866314438 113 236 463 53 230 291 195 2 2 101 67 71 M17561 GO_ANCHORING_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORING_JUNCTION.html A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. 349/772 Gene Ontology CC GO:0070161 0.156419386037904 0.321811663327751 100 150.090909090909 113 0.0153446713129792 80 1.25181829983217 1.35642891855953 1 2.38051442069342 98 202 92 92 163 421 168 80 113 96 126 72 M17185 GO_CLATHRIN_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT.html A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. 38/66 Gene Ontology CC GO:0030118 0.0340260570239837 0.135763469281686 70 136.363636363636 114 0.00314218200574958 41 1.11430480833076 -1.01405746558881 -1 3.73202780231802 131 145 366 248 41 55 67 70 114 178 85 73 M17796 GO_PHOTORECEPTOR_OUTER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT.html The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes. 33/111 Gene Ontology CC GO:0001750 0.0839184282471183 0.198790375109977 115 223.909090909091 115 0.00793650793650794 18 1.70744269261732 2.06616939822547 1 4.62649012898372 225 115 114 68 515 531 431 82 18 74 290 74 M17194 GO_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LUMEN.html The volume enclosed by the membrane or protein that forms a vesicle. 54/213 Gene Ontology CC GO:0031983 0.000269352727743887 0.00446727044632834 35 125 116 2.44896100977938e-05 26 1.22407556104018 1.22407556104018 1 11.1091627556977 33 33 26 116 104 277 109 149 182 144 202 75 M17637 GO_LYTIC_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE.html A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. 310/770 Gene Ontology CC GO:0000323 0.00569853103178552 0.0433388281101583 455 243.181818181818 118 0.000519395032027738 11 1.39541135493816 1.58632338978456 1 7.3459893321174 455 118 43 99 61 425 483 394 52 11 534 76 M17285 GO_STEREOCILIUM_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEREOCILIUM_BUNDLE.html A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. 19/77 Gene Ontology CC GO:0032421 0.0801272870813013 0.198790375109977 95 191.636363636364 119 0.00756397299090064 21 1.88080416156878 1.88080416156878 1 5.09623071197955 399 94 157 61 83 91 119 558 21 209 316 77 M17755 GO_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REGION.html A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane. 543/1581 Gene Ontology CC GO:0098589 0.00136574806685029 0.0167773627380467 45 143.909090909091 122 0.000136658816410537 9 1.35170963447042 1.4186673488252 1 9.26749612515566 41 25 567 41 172 271 122 64 135 9 136 78 M17236 GO_NUCLEAR_NUCLEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_NUCLEOSOME.html A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. 29/61 Gene Ontology CC GO:0000788 0.000190344954933447 0.0036018410802274 10 118.272727272727 123 1.73055841506072e-05 9 1.20074158169684 -1.20074158169684 -1 11.3310610179828 9 100 71 220 205 128 108 40 163 134 123 79 M17625 GO_T_TUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_TUBULE.html Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. 26/87 Gene Ontology CC GO:0030315 0.0709859259900934 0.198790375109977 125 139.727272727273 124 0.00667140945992956 51 1.19838839406667 1.19838839406667 1 3.24715558351638 83 171 87 183 124 145 105 51 299 121 168 80 M17662 GO_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE.html Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. 154/351 Gene Ontology CC GO:0030135 0.0076092452225125 0.0523588540310979 485 216.363636363636 125 0.000694153802987603 14 1.31401715452306 1.36704295009536 1 6.50079628938361 485 17 125 31 14 211 486 357 101 55 498 81 M17007 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE.html A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. 23/33 Gene Ontology CC GO:0000407 0.0839184282471183 0.198790375109977 85 163.272727272727 126 0.00793650793650794 70 0.776975717544185 -0.776975717544185 -1 2.10529495238081 85 84 340 227 211 87 135 126 70 342 89 82 M17195 GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION.html Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. 17/43 Gene Ontology CC GO:0098636 0.0629489899778073 0.191497453721961 80 195.909090909091 126 0.00589325339059418 30 1.4630379028186 1.4630379028186 1 4.05596745765775 77 475 126 233 533 100 30 118 258 78 127 83 M17264 GO_ENDOPLASMIC_RETICULUM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_PART.html Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. 607/1512 Gene Ontology CC GO:0044432 0.0396209854962973 0.142241798862483 505 228.454545454545 127 0.00403456574810355 6 1.2578018726658 1.3614988109183 1 4.1142883773107 503 6 480 28 127 63 454 548 55 21 228 84 M17098 GO_EXOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE.html A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. 70/211 Gene Ontology CC GO:0070382 0.0185224281428751 0.0947430395272726 210 130.909090909091 128 0.0016982033645535 24 1.23100731315173 -1.03465305361454 -1 4.8656565490552 206 67 205 158 26 24 128 219 86 260 61 85 M17549 GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX.html A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. 12/20 Gene Ontology CC GO:0005942 0.0782452343873041 0.198790375109977 115 177 129 0.00737955201148736 52 0.437569087410893 -0.484378437831589 -1 1.18563806855444 114 129 250 152 279 113 120 52 172 501 65 86 M17754 GO_PROTEIN_LIPID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX.html A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. 17/64 Gene Ontology CC GO:0032994 0.164269041887066 0.331984287450084 75 150.727272727273 129 0.0161811589139185 52 1.55737637553068 -1.20555776449092 -1 2.88028570563418 75 52 86 129 218 317 68 230 232 79 172 87 M17522 GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK.html The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. 537/1316 Gene Ontology CC GO:0042175 0.0356926838087202 0.137535808276268 380 209 131 0.00362792735592713 32 1.18638109770676 1.29388607762315 1 3.94761690010446 380 40 527 107 191 32 349 369 73 100 131 88 M17709 GO_MYOSIN_II_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_II_COMPLEX.html A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. 8/31 Gene Ontology CC GO:0016460 0.00193863582120668 0.0211421038614616 70 220.272727272727 131 0.000194032913961869 2 2.07333958077616 -2.07333958077616 -1 13.410960077822 69 376 558 274 568 27 2 131 235 130 53 89 M17801 GO_PLASMA_MEMBRANE_RAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RAFT.html A membrane raft that is part of the plasma membrane. 63/155 Gene Ontology CC GO:0044853 0.0152772152767851 0.0840686565746964 50 147.454545454545 131 0.00139857691937593 23 1.32900936654931 1.32033193363838 1 5.51946961148271 48 207 48 105 131 358 208 98 193 23 203 90 M17802 GO_MICROBODY_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_LUMEN.html The volume enclosed by the membranes of a microbody. 23/53 Gene Ontology CC GO:0031907 0.00314864490694226 0.0308460467154683 275 178.818181818182 132 0.000286650936779635 6 0.722840167654169 -0.722840167654169 -1 4.21757137756935 64 132 275 254 6 38 276 58 273 564 27 91 M17315 GO_MYELIN_SHEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_SHEATH.html An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. 124/303 Gene Ontology CC GO:0043209 0.0230049771040533 0.104699817056242 330 209.363636363636 133 0.00211355612668742 34 1.3037514857836 1.26796040868765 1 4.93466759102617 329 66 130 96 34 248 424 320 71 133 452 92 M17514 GO_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIDE_OF_MEMBRANE.html A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. 215/702 Gene Ontology CC GO:0098552 2.59458085441721e-08 1.87458466731644e-06 55 157.909090909091 133 2.35870989546957e-09 7 1.38610854381398 1.42842652958702 1 30.6580600426689 51 217 7 243 252 347 115 89 198 85 133 93 M17009 GO_MUSCLE_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_MYOSIN_COMPLEX.html A filament of myosin found in a muscle cell of any type. 7/27 Gene Ontology CC GO:0005859 0.114060782966666 0.252746492561839 105 208.272727272727 134 0.0120376541545848 47 2.07333958077616 -2.07333958077616 -1 4.78285050562022 102 400 434 282 353 78 47 134 234 111 116 94 M17654 GO_WNT_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALOSOME.html A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. 10/21 Gene Ontology CC GO:1990909 0.00358056033664781 0.0339272766324989 135 136.363636363636 134 0.000326036464505524 6 1.86235441726781 1.86235441726781 1 10.5689170503535 67 273 134 64 387 135 15 6 211 153 55 95 M17697 GO_MICROBODY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_PART.html Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 54/112 Gene Ontology CC GO:0044438 0.00484377859312361 0.0386101821814285 135 163.818181818182 134 0.000441316019488821 9 0.83074329694245 -0.804379906228381 -1 4.53433583414659 134 79 304 161 9 40 222 73 179 541 60 96 M17320 GO_PLATELET_ALPHA_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet alpha granule. 29/92 Gene Ontology CC GO:0031093 0.0297620868893108 0.123341053355889 90 176.636363636364 135 0.00274295541451974 58 1.22883726602391 1.22883726602391 1 4.31340131971272 90 93 58 121 250 362 240 74 261 135 259 97 M17518 GO_CLATHRIN_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated vesicle. 44/104 Gene Ontology CC GO:0030665 0.0599629125539572 0.184604735765807 455 264.363636363636 137 0.00560567919424448 38 1.46259377791736 1.57472785599949 1 4.14466202251035 454 107 137 89 63 400 529 390 126 38 575 98 M17798 GO_BASAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PART_OF_CELL.html The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. 35/84 Gene Ontology CC GO:0045178 0.0112522524567546 0.0677479366667099 140 161.181818181818 137 0.00102820176413778 18 1.58805796060312 1.58805796060312 1 7.17022057014313 18 328 45 262 359 193 70 137 137 47 177 99 M17698 GO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS.html A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. 783/1929 Gene Ontology CC GO:0005794 0.00957674802209719 0.0608281357887052 555 249.454545454545 138 0.000961827144142179 5 1.31513205729761 1.46953412558053 1 6.175592909818 554 5 556 138 80 132 561 278 74 14 352 100 M17353 GO_COPI_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE.html A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. 17/32 Gene Ontology CC GO:0030137 0.00168071437827975 0.0198255696050141 150 152.636363636364 139 0.000152909068511888 5 0.34782541063315 -0.356044870557637 -1 2.28734379998131 148 37 345 139 5 22 44 288 149 431 71 101 M17574 GO_CILIARY_BASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASE.html Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. 13/25 Gene Ontology CC GO:0097546 0.0326327855560878 0.132829225714216 230 189.272727272727 139 0.00301155700536535 24 1.49234186417521 1.49234186417521 1 5.05283976106094 228 101 288 75 512 68 24 355 121 171 139 102 M17182 GO_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON.html The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. 238/668 Gene Ontology CC GO:0030424 0.0421141565772911 0.148316599094393 260 224.090909090909 140 0.00390387539417646 40 1.2964645988817 -1.08146706620653 -1 4.14981578445614 258 140 62 93 119 473 317 449 59 40 455 103 M17759 GO_MEDIATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEDIATOR_COMPLEX.html A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. 19/36 Gene Ontology CC GO:0016592 0.113962020917629 0.252746492561839 395 246.727272727273 140 0.0109393133283834 62 0.1867828839098 -0.235481625280556 -1 0.430877125975785 76 304 395 393 140 71 126 133 459 555 62 104 M17381 GO_CLATHRIN_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_VESICLE_COAT.html A clathrin coat found on a vesicle. 20/32 Gene Ontology CC GO:0030125 0.0481354710899905 0.161143476502029 150 145.727272727273 142 0.004474736208493 43 1.11430480833076 -1.01405746558881 -1 3.41172265874043 166 239 322 148 56 118 142 148 43 92 129 105 M17280 GO_AXONAL_GROWTH_CONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_GROWTH_CONE.html The migrating motile tip of a growing nerve cell axon. 23/44 Gene Ontology CC GO:0044295 0.0839184282471183 0.198790375109977 205 159.272727272727 143 0.00793650793650794 23 1.28675867799768 -1.15524578701792 -1 3.48660388159743 204 188 127 32 143 396 121 162 23 56 300 106 M17416 GO_RUFFLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_MEMBRANE.html The portion of the plasma membrane surrounding a ruffle. 57/146 Gene Ontology CC GO:0032587 0.0152204834458712 0.0840686565746964 375 210.090909090909 143 0.00139334692844537 21 1.17847037954792 1.27394356906928 1 4.89427058287565 278 143 81 56 21 525 236 373 140 86 372 107 M17560 GO_INTRACILIARY_TRANSPORT_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE.html A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. 19/39 Gene Ontology CC GO:0030990 0.00287039926634939 0.0291068557184201 10 166.454545454545 145 0.000261286473523102 6 1.17745088006767 -0.862559895960135 -1 6.98471020961529 66 85 287 145 370 6 16 329 309 211 7 108 M17176 GO_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COAT.html A membrane coat found on a coated vesicle. 31/55 Gene Ontology CC GO:0030120 0.0243115899099996 0.107267931053281 105 148.909090909091 146 0.0022349529014686 36 1.11430480833076 -1.01405746558881 -1 4.1723270764722 161 233 348 189 36 50 101 175 104 146 95 109 M17327 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE.html A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. 29/77 Gene Ontology CC GO:0045334 0.131750489075236 0.282416408719646 125 198.636363636364 146 0.0127611633719353 36 1.57472785599949 1.57472785599949 1 3.33947324177817 216 146 83 137 121 518 271 283 122 36 252 110 M17436 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_.html All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. 8/16 Gene Ontology CC GO:0045263 0.170084750887681 0.337831567055256 100 192.363636363636 147 0.0184704603562278 85 0.200566826832755 -0.200566826832755 -1 0.365064307649074 99 174 504 147 144 99 85 163 151 454 96 111 M17073 GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX.html Any protein complex that is part of the plasma membrane and which functions as a receptor. 71/236 Gene Ontology CC GO:0098802 0.185841346446768 0.364123044902481 80 204 150 0.0185173195714685 78 1.28068180474084 1.40750563847265 1 2.17006743956011 78 423 138 293 330 246 129 90 150 122 245 112 M17360 GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX.html Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. 10/41 Gene Ontology CC GO:0005834 0.17377999428068 0.343989166761072 70 173.818181818182 151 0.0172043036262288 58 1.46693471565438 1.46693471565438 1 2.62561850498551 70 124 181 223 435 282 58 110 173 151 105 113 M17763 GO_AXON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_PART.html A part of an axon, a cell projection of a neuron. 133/371 Gene Ontology CC GO:0033267 0.0839184282471183 0.198790375109977 200 196.545454545455 151 0.00793650793650794 46 1.29892414614059 -1.05902894011912 -1 3.51956745840855 196 151 103 110 89 456 167 395 46 69 380 114 M17774 GO_COATED_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_MEMBRANE.html A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. 59/109 Gene Ontology CC GO:0048475 0.0151046651938508 0.0840686565746964 140 162.272727272727 152 0.00138267073206096 14 1.11430480833076 -1.01405746558881 -1 4.62778644083333 136 219 388 268 182 14 71 79 152 245 31 115 M17784 GO_CILIARY_BASAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASAL_BODY.html A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. 44/106 Gene Ontology CC GO:0036064 0.0801764327653603 0.198790375109977 125 179.727272727273 153 0.00756879333489094 21 0.965601697357932 -0.631262575792853 -1 2.61639628453829 125 21 314 114 253 51 98 237 332 279 153 116 M17403 GO_GOLGI_ASSOCIATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE.html Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. 60/113 Gene Ontology CC GO:0005798 0.0194931788131326 0.0956504690311516 40 173.181818181818 154 0.00178800656508346 19 1.02237527887538 -1.02237527887538 -1 4.02467582723683 107 264 381 289 38 19 62 154 307 248 36 117 M17108 GO_GOLGI_STACK http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_STACK.html The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. 80/184 Gene Ontology CC GO:0005795 0.0388936112994899 0.142241798862483 155 202.090909090909 155 0.00359988390671837 31 1.08295103344068 1.08295103344068 1 3.54234871635049 155 285 237 379 101 31 125 146 382 305 77 118 M17521 GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. 3/14 Gene Ontology CC GO:0031235 0.0515668728071066 0.169350298196066 130 214.454545454545 155 0.00528040895235778 44 0.586221990335533 0.586221990335533 1 1.74602346431762 100 216 526 146 126 183 155 44 248 487 128 119 M17656 GO_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION.html A prolongation or process extending from a cell, e.g. a flagellum or axon. 902/2503 Gene Ontology CC GO:0042995 0.0765897756730953 0.198790375109977 480 270.909090909091 156 0.00793650793650794 58 1.2668039445102 1.49420534713021 1 3.43253449583006 478 90 550 124 156 80 555 485 82 58 322 120 M17097 GO_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_PIT.html A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. 42/85 Gene Ontology CC GO:0005905 0.024255223755779 0.107267931053281 205 185.909090909091 157 0.00222971289943881 35 1.56187356882157 1.56187356882157 1 5.84817308075258 140 144 306 153 35 376 133 205 157 191 205 121 M17301 GO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. 257/549 Gene Ontology CC GO:0000785 0.142439802630597 0.301575845862582 75 209.909090909091 157 0.0138723256393962 71 1.30913021696809 -1.10404009908228 -1 2.63210331231951 71 416 142 490 157 81 165 78 314 307 88 122 M17127 GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinase (CDK) complex found in the nucleus. 10/20 Gene Ontology CC GO:0019908 0.0100879052514767 0.0626968734984249 160 194.636363636364 158 0.000921314690505015 7 1.73041933125535 1.73041933125535 1 8.03787516472959 158 430 285 207 500 219 118 13 7 148 56 123 M17190 GO_CLATHRIN_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE.html A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. 92/208 Gene Ontology CC GO:0030136 0.0100169814929301 0.0626968734984249 20 201.727272727273 158 0.000914807583064112 17 1.39061033029145 1.57472785599949 1 6.45944716046001 487 19 124 26 17 158 293 552 168 71 304 124 M17408 GO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE.html The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. 361/1081 Gene Ontology CC GO:0045202 0.00241226905476457 0.0248980627438201 35 211.727272727273 158 0.000219538012845965 33 1.30761526360187 1.40696025821105 1 8.09939471652357 253 58 34 80 158 401 447 315 69 33 481 125 M17531 GO_LAMELLIPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM.html A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. 129/281 Gene Ontology CC GO:0030027 0.0954077110910218 0.223261769273727 160 185.272727272727 159 0.00907411998396578 27 1.30005856730322 1.34699085735633 1 3.26949575483946 159 276 78 27 227 430 219 125 139 67 291 126 M17076 GO_MICROBODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_MEMBRANE.html The lipid bilayer surrounding a microbody. 36/69 Gene Ontology CC GO:0031903 0.006952401987543 0.0502602264333839 285 180.909090909091 161 0.000634042777006161 13 0.794068548999117 -0.736186088956347 -1 3.98295270265245 282 108 293 100 13 126 225 177 138 367 161 127 M17088 GO_SECRETORY_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_LUMEN.html The volume enclosed by the membrane of a secretory granule. 40/169 Gene Ontology CC GO:0034774 0.00831994130629883 0.056575600882832 165 154.727272727273 161 0.000759233926558294 41 1.22883726602391 1.22883726602391 1 5.91974504108213 54 80 41 119 161 302 164 130 239 183 229 128 M17250 GO_NODE_OF_RANVIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NODE_OF_RANVIER.html An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. 8/32 Gene Ontology CC GO:0033268 0.111852019704912 0.250583206935811 120 243.272727272727 163 0.0117916180216442 45 0.386266087391768 0.564623661354619 1 0.896620797420225 120 438 477 357 145 133 45 84 297 417 163 129 M17573 GO_PODOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PODOSOME.html An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. 12/34 Gene Ontology CC GO:0002102 0.0191665961870762 0.0956504690311516 165 162.909090909091 163 0.00175778570545127 18 0.997293395573521 0.997293395573521 1 3.92593864954997 37 165 187 163 267 172 18 124 128 511 20 130 M17635 GO_CELL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_BODY.html The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. 297/774 Gene Ontology CC GO:0044297 0.000270509456092546 0.00446727044632834 270 201.636363636364 163 2.45947930317561e-05 20 1.41693473105792 1.58867599446403 1 12.8594663954183 267 163 27 141 152 403 331 206 60 20 448 131 M16981 GO_MULTIVESICULAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY.html A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 17/51 Gene Ontology CC GO:0005771 0.0839184282471183 0.198790375109977 165 168.090909090909 164 0.00793650793650794 25 1.22445449499089 -1.23435683890907 -1 3.31778434271315 236 38 164 87 233 306 161 172 25 77 350 132 M17251 GO_COMPACT_MYELIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPACT_MYELIN.html The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. 10/26 Gene Ontology CC GO:0043218 0.197392952002664 0.374593891016035 115 183.090909090909 164 0.0197915281979204 103 0.847808867288674 0.847808867288674 1 1.39626622146651 121 204 190 115 150 221 103 164 213 418 115 133 M17710 GO_MICROTUBULE_ORGANIZING_CENTER_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_PART.html Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. 74/194 Gene Ontology CC GO:0044450 0.101826357143166 0.235422537715 110 237.363636363636 165 0.00971539428819787 61 0.743128926420273 -0.743128926420273 -1 1.80277669045212 108 318 299 336 151 61 95 165 458 546 74 134 M17550 GO_INTRACILIARY_TRANSPORT_PARTICLE_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE_B.html The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. 12/24 Gene Ontology CC GO:0030992 0.00428282221296254 0.0365512216734406 170 196.818181818182 167 0.00039010750340014 6 0.296087617517655 -0.338924316119492 -1 1.64331079206456 49 123 294 167 398 8 6 167 440 502 11 135 M17643 GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX.html Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. 67/172 Gene Ontology CC GO:0031461 0.0148662200501391 0.0840686565746964 170 217.272727272727 169 0.00136069430799829 13 0.525602276263726 -0.525602276263726 -1 2.18286331149522 169 257 335 361 91 13 73 142 350 530 69 136 M17674 GO_PRESYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPSE.html The part of a synapse that is part of the presynaptic cell. 132/414 Gene Ontology CC GO:0098793 0.0089874232162324 0.0589997948646917 350 152.636363636364 169 0.000820395448747555 9 1.42981253567548 -1.19621898996815 -1 6.7872970332613 348 105 194 169 65 9 239 182 85 254 29 137 M17281 GO_PROTEIN_DNA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX.html A macromolecular complex containing both protein and DNA molecules. 88/191 Gene Ontology CC GO:0032993 0.0549498883283334 0.176117084748444 30 167.545454545455 170 0.00512476197639866 27 1.2451718004747 -1.2451718004747 -1 3.62683664059743 27 170 128 315 209 185 172 108 147 238 144 138 M17741 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated endocytic vesicle. 25/55 Gene Ontology CC GO:0030669 0.109415756374531 0.248009047782271 170 195.818181818182 170 0.0104790336024818 28 1.57472785599949 1.57472785599949 1 3.68261227422134 170 226 96 157 240 483 215 143 123 28 273 139 M17245 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX.html A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. 25/53 Gene Ontology CC GO:0016469 0.100781476443051 0.233942543711178 75 205.090909090909 172 0.00961071899112853 74 0.801505046067566 -0.801505046067566 -1 1.95287072937348 74 172 393 247 94 110 152 209 305 414 86 140 M17273 GO_BLOOD_MICROPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_MICROPARTICLE.html A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. 66/447 Gene Ontology CC GO:0072562 0.002345389911109 0.0246479157931091 110 240 174 0.000213444912497688 33 1.29203231455593 1.51238725383738 1 8.02475583502087 274 114 33 108 174 578 190 478 148 106 437 141 M17626 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT.html A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. 77/169 Gene Ontology CC GO:0005793 0.00132267359829025 0.0166196813002558 45 193.636363636364 174 0.000120315407257504 27 1.19168785990109 1.35897149268293 1 8.18924020929252 334 43 32 43 27 372 298 233 174 81 493 142 M17689 GO_DENDRITE_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_CYTOPLASM.html All of the contents of a dendrite, excluding the surrounding plasma membrane. 13/26 Gene Ontology CC GO:0032839 0.188744166473886 0.366087678597 95 210.909090909091 174 0.0188359636771983 92 1.01405746558881 -1.01405746558881 -1 1.70913028772409 147 334 282 301 341 108 153 92 295 174 93 143 M17307 GO_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION.html A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. 635/1673 Gene Ontology CC GO:0030054 0.308302654638503 0.493049222615674 160 204.909090909091 176 0.0361895941297155 51 1.29416661509827 1.39919651939116 1 1.53495908092999 91 176 486 185 219 365 158 157 197 51 169 144 M17722 GO_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE.html Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. 195/538 Gene Ontology CC GO:0030133 0.0381179211687196 0.142241798862483 180 254.090909090909 176 0.00352680389376411 47 1.24505041315496 1.34128874511497 1 4.07257816612902 535 126 176 216 47 134 475 467 176 123 320 145 M17101 GO_PERINUCLEAR_REGION_OF_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_REGION_OF_CYTOPLASM.html Cytoplasm situated near, or occurring around, the nucleus. 405/983 Gene Ontology CC GO:0048471 0.0449890604639789 0.153867910935975 460 242.545454545455 177 0.00417602727858347 32 1.43704837683454 1.61638303356901 1 4.51123949070496 457 177 65 128 110 214 543 440 72 32 430 146 M17525 GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN.html The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. 14/28 Gene Ontology CC GO:0035327 0.0513722965268282 0.169350298196066 135 224.727272727273 177 0.00478296695255404 37 0.253029031629305 -0.319098589627448 -1 0.753630248808127 133 369 321 434 177 83 48 37 339 488 43 147 M17091 GO_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. 239/581 Gene Ontology CC GO:0015629 0.0839184282471183 0.198790375109977 485 257.818181818182 178 0.00793650793650794 44 1.3912000394573 1.46755585062438 1 3.76959840349236 484 120 79 65 212 178 517 566 44 84 487 148 M17154 GO_ROUGH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM.html The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. 47/110 Gene Ontology CC GO:0005791 0.0839184282471183 0.198790375109977 380 242.545454545455 180 0.00793650793650794 10 1.46753254383791 1.7298283934822 1 3.97642911002795 378 10 111 36 376 315 577 180 37 117 531 149 M17438 GO_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the Golgi apparatus. 415/943 Gene Ontology CC GO:0000139 0.0468108673408171 0.158779287749362 440 234.545454545455 180 0.00434887384441628 53 1.19656067385817 1.34878119600797 1 3.69323199686573 438 117 180 221 53 125 468 520 141 60 257 150 M17810 GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the plasma membrane. 221/687 Gene Ontology CC GO:0098797 0.11412947155474 0.252746492561839 45 210.818181818182 180 0.0109563075795037 44 1.41972029430631 1.47930900676784 1 3.27505922647984 44 494 84 422 385 241 124 63 225 57 180 151 M17385 GO_CILIARY_TRANSITION_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TRANSITION_ZONE.html A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition. 15/25 Gene Ontology CC GO:0035869 0.131340252349113 0.282416408719646 115 249.090909090909 181 0.0127187672353458 56 0.285696367540094 -0.276785111150125 -1 0.605866825505073 111 181 301 317 564 76 56 168 409 438 119 152 M17647 GO_MAIN_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAIN_AXON.html The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. 33/108 Gene Ontology CC GO:0044304 0.0667072837629408 0.194731363712019 35 236.727272727273 182 0.00625638234807526 31 0.931951048591966 -0.931951048591966 -1 2.55746327698334 34 381 182 269 497 111 31 156 272 531 140 153 M17816 GO_CLATHRIN_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_ADAPTOR_COMPLEX.html A membrane coat adaptor complex that links clathrin to a membrane. 20/34 Gene Ontology CC GO:0030131 0.248560429624087 0.435357358553705 115 205.090909090909 182 0.0256440492134748 78 1.21455215107271 1.21455215107271 1 1.69403264704858 182 329 358 350 180 115 78 111 201 222 130 154 M17308 GO_NUCLEAR_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. 177/368 Gene Ontology CC GO:0000790 0.210934049175057 0.390768847510201 110 213.363636363636 183 0.0213065901620281 89 1.36092924391204 -1.2451718004747 -1 2.14483542187663 89 425 147 468 183 96 186 107 246 293 107 155 M17439 GO_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a coated vesicle. 89/202 Gene Ontology CC GO:0030662 0.0570620066011572 0.180228632871415 430 264.818181818182 183 0.00532710159442296 60 1.28694094630916 1.33242152642922 1 3.69868587661272 428 178 183 175 60 232 474 549 129 107 398 156 M17614 GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME.html Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. 50/110 Gene Ontology CC GO:0016591 0.168040938556731 0.336081877113462 185 276.363636363636 183 0.0165856494359307 106 0.222275856176769 -0.234522367557682 -1 0.40651415549481 183 348 404 456 136 124 132 106 462 522 167 157 M17039 GO_CYTOPLASMIC_STRESS_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_STRESS_GRANULE.html A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. 15/44 Gene Ontology CC GO:0010494 0.00435875052809629 0.0365512216734406 130 176.636363636364 184 0.000397037303027627 8 1.16186250822327 -1.16186250822327 -1 6.44843313516309 130 341 208 325 289 53 72 8 296 184 37 158 M17239 GO_GOLGI_APPARATUS_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS_PART.html Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. 496/1202 Gene Ontology CC GO:0044431 0.0122319788658953 0.0721437120866072 85 228.545454545455 184 0.00111822933566036 16 1.26326409042549 1.39645024452248 1 5.57054661818888 534 82 82 200 49 184 553 426 67 16 321 159 M17329 GO_ARP2_3_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_PROTEIN_COMPLEX.html A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. 6/11 Gene Ontology CC GO:0005885 0.0960253369755676 0.223800986983379 170 259.272727272727 185 0.0100446072144997 42 0.625059557561618 -0.625059557561618 -1 1.56942294838462 356 166 487 168 106 374 42 160 185 427 381 160 M17691 GO_PERIKARYON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIKARYON.html The portion of the cell soma (cell body) that excludes the nucleus. 80/202 Gene Ontology CC GO:0043204 0.0817825445491917 0.198790375109977 235 197.636363636364 185 0.00772645419900132 62 1.38758513903759 1.72953809847857 1 3.75980346208527 231 185 73 76 235 499 187 151 62 91 384 161 M17823 GO_DENSE_CORE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENSE_CORE_GRANULE.html Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. 3/17 Gene Ontology CC GO:0031045 0.273534154352022 0.460633830574186 155 277.181818181818 185 0.0314511716392981 144 0.42164820381873 0.42164820381873 1 0.548194146628279 151 238 576 258 185 161 144 152 454 572 158 162 M17065 GO_PLATELET_ALPHA_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE.html A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). 43/117 Gene Ontology CC GO:0031091 0.00330357345342325 0.0318244242679773 60 191.363636363636 186 0.000300776784864973 35 1.22883726602391 1.22883726602391 1 7.10556604474918 60 164 35 186 307 294 145 103 377 194 240 163 M17305 GO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MATRIX.html The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. 262/496 Gene Ontology CC GO:0005759 0.0300315104148086 0.123341053355889 50 200.818181818182 186 0.00276813372153856 39 0.786303828157816 -0.733287435041193 -1 2.76004322237235 50 96 411 368 39 109 202 186 294 320 134 164 M17174 GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE.html The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 9/16 Gene Ontology CC GO:0031231 0.0294227224839451 0.123341053355889 95 189.363636363636 187 0.00298197037236325 23 0.328642194392709 -0.325100315599591 -1 1.15358291040341 224 241 460 188 92 88 23 95 187 391 94 165 M17356 GO_PERICENTRIC_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIC_HETEROCHROMATIN.html Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. 10/18 Gene Ontology CC GO:0005721 0.463502587456482 0.653606363325543 190 245.454545454545 189 0.0550360530721686 79 1.33403223803043 -1.33403223803043 -1 0.951498269686298 79 394 156 343 358 187 189 249 425 150 170 166 M17577 GO_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_COMPLEX.html Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. 14/52 Gene Ontology CC GO:0030286 0.0217418516735787 0.101345082801036 215 217.090909090909 192 0.00199633996946119 19 0.554099100968402 -0.554099100968402 -1 2.12751719624916 215 392 324 320 164 60 113 76 192 513 19 167 M17049 GO_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEMBRANE.html The lipid bilayer surrounding any membrane-bounded vesicle in the cell. 295/700 Gene Ontology CC GO:0012506 0.0240388777481739 0.107267931053281 400 256.818181818182 193 0.00220960314505821 53 1.28943770501493 1.40735106264937 1 4.8280827748913 400 193 53 132 98 402 425 336 180 59 547 168 M17707 GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX.html Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). 27/45 Gene Ontology CC GO:0030119 0.042348477415163 0.148316599094393 110 192.090909090909 193 0.00392602948934598 26 1.21455215107271 1.21455215107271 1 3.88762461499994 110 366 371 388 193 62 26 60 204 246 87 169 M17017 GO_PHOSPHATASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_COMPLEX.html A protein complex which is capable of phosphatase activity. 21/58 Gene Ontology CC GO:1903293 0.0300883884484089 0.123341053355889 130 243.090909090909 195 0.00277344992980156 23 0.261598913759521 0.258204365315726 1 0.918251037300211 128 195 375 318 84 167 43 572 422 347 23 170 M17371 GO_INTRACELLULAR_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_VESICLE.html Any vesicle that is part of the intracellular region. 696/1799 Gene Ontology CC GO:0097708 0.0622964688564967 0.190515126979127 125 240.454545454545 195 0.0064115025211482 24 1.33327963145175 1.44845318085624 1 3.70774050675354 223 125 494 125 72 520 255 195 112 24 500 171 M17598 GO_MICROTUBULE_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_END.html Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. 14/27 Gene Ontology CC GO:1990752 0.383878918966316 0.574203784463481 175 340.272727272727 196 0.0430731652316535 148 0.236554114329586 -0.250441635217245 -1 0.220110896055421 172 553 196 528 555 148 191 174 534 519 173 172 M17543 GO_NADH_DEHYDROGENASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX.html An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. 31/51 Gene Ontology CC GO:0030964 0.0837435638936997 0.198790375109977 40 250.363636363636 197 0.00791929415668562 38 0.564322045552235 -0.564322045552235 -1 1.52908813744161 39 384 398 424 197 57 38 181 469 497 70 173 M17711 GO_NUCLEAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE.html Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. 153/392 Gene Ontology CC GO:0031965 0.038714479234944 0.142241798862483 370 218.454545454545 197 0.00358300259608417 30 1.43731674044867 1.44428753323014 1 4.70148414412576 370 240 220 352 133 30 490 184 153 197 34 174 M17659 GO_CILIARY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_MEMBRANE.html The portion of the plasma membrane surrounding a cilium. 36/102 Gene Ontology CC GO:0060170 0.00109945016496701 0.014121826563354 470 221.545454545455 198 1e-04 4 1.71951239261581 2.04314270252788 1 12.2861468787627 469 22 91 4 363 303 508 198 11 27 441 175 M17490 GO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION.html A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 994/2090 Gene Ontology CC GO:0005739 0.0192366116049031 0.0956504690311516 140 226.909090909091 199 0.00194051903417326 31 1.1210614899879 1.24654227900922 1 4.41316332016519 139 175 518 523 31 70 201 214 199 325 101 176 M17679 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE.html A cellular membrane associated with the pre-autophagosomal structure. 15/18 Gene Ontology CC GO:0034045 0.0839184282471183 0.198790375109977 200 261.272727272727 199 0.00793650793650794 88 0.757413120848284 -0.757413120848284 -1 2.05228810124818 197 180 374 271 460 166 199 215 88 538 186 177 M17640 GO_ESC_E_Z_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESC_E_Z_COMPLEX.html A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. 13/20 Gene Ontology CC GO:0035098 0.068122801349359 0.196874895899648 200 206.636363636364 200 0.0063934953537372 69 1.13115893914357 -1.13115893914357 -1 3.08336029522575 198 208 200 249 69 226 338 301 127 173 184 178 M17139 GO_MYOFILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFILAMENT.html Any of the smallest contractile units of a myofibril (striated muscle fiber). 16/34 Gene Ontology CC GO:0036379 0.0144389079391885 0.0840686565746964 205 218.909090909091 201 0.00132132295413864 47 3.11553755502548 -3.11553755502548 -1 12.9390471592187 283 311 47 381 201 203 149 153 188 190 302 179 M17150 GO_NEURON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PART.html Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 647/1803 Gene Ontology CC GO:0097458 0.0765897756730953 0.198790375109977 120 281.727272727273 201 0.00793650793650794 37 1.33196850294098 1.50994252890559 1 3.60910451368397 402 192 457 201 116 120 573 471 77 37 453 180 M17085 GO_CYTOPLASMIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_REGION.html Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\ 188/475 Gene Ontology CC GO:0099568 0.0839184282471183 0.198790375109977 560 276.363636363636 202 0.00793650793650794 20 1.16782735683991 1.36157004402906 1 3.16434733592431 557 74 99 20 202 330 575 477 79 162 465 181 M17201 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX.html A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. 10/56 Gene Ontology CC GO:0008328 0.379793794354911 0.570183930226334 130 280.636363636364 203 0.0424980962520289 129 0.791140711360448 -0.791140711360448 -1 0.745469624956486 129 343 203 355 548 195 138 129 464 396 187 182 M17404 GO_PROTEASOME_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_CORE_COMPLEX.html A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. 11/22 Gene Ontology CC GO:0005839 0.257608037067502 0.445674214502731 205 219.909090909091 203 0.0267164405185593 53 0.260580706877258 -0.262799537222956 -1 0.353216311995186 127 53 391 235 168 160 205 240 203 446 191 183 M17619 GO_CYTOPLASMIC_VESICLE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_VESICLE_PART.html Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. 331/882 Gene Ontology CC GO:0044433 0.000505099658477244 0.00729869006499617 215 214.363636363636 203 4.59286965433618e-05 29 1.28458966989565 1.38856013668879 1 10.6006432030262 212 150 29 120 112 551 262 203 218 54 447 184 M17808 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX.html A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. 14/28 Gene Ontology CC GO:0045259 0.257405409517189 0.445674214502731 170 234.818181818182 204 0.0266922938033066 103 0.193973238160004 -0.21004660139262 -1 0.262930100393431 103 133 403 204 167 169 220 229 222 567 166 185 M17257 GO_DENDRITIC_SHAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SHAFT.html Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. 20/67 Gene Ontology CC GO:0043198 0.0664116091121401 0.194731363712019 220 173.818181818182 205 0.00622776592476755 40 1.20206536347305 -0.889829409089437 -1 3.29871191178701 314 288 216 88 88 205 180 49 40 220 224 186 M16983 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. 7/18 Gene Ontology CC GO:0034362 0.0159992252996827 0.0840686565746964 210 195.363636363636 207 0.00161155950446568 24 1.55737637553068 -1.20555776449092 -1 6.46789390358806 214 63 429 73 24 352 382 208 155 42 207 187 M17675 GO_A_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_A_BAND.html The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. 18/72 Gene Ontology CC GO:0031672 0.0290085612886498 0.123338846101962 210 230.909090909091 207 0.00267257028190819 57 2.07333958077616 -2.07333958077616 -1 7.27779211258185 207 282 57 292 481 94 207 262 310 207 141 188 M17488 GO_VACUOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PART.html Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. 433/967 Gene Ontology CC GO:0044437 0.161385165508919 0.327300440926861 450 261.727272727273 209 0.0158730158730159 35 1.32149842468199 1.550791087753 1 2.47553606608434 449 162 152 209 138 216 491 577 107 35 343 189 M17624 GO_PSEUDOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOPODIUM.html A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. 14/28 Gene Ontology CC GO:0031143 0.0073058376722744 0.0513186386674837 115 224.545454545455 209 0.000666382959497008 8 0.400797463558555 -0.403932467148493 -1 1.99634265401516 112 330 209 277 389 52 90 96 381 526 8 190 M17648 GO_LAMELLAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLAR_BODY.html A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. 10/26 Gene Ontology CC GO:0042599 0.232850105696956 0.415393089792717 245 230.363636363636 210 0.0238095238095238 120 1.23435683890907 -1.23435683890907 -1 1.81884077895934 243 182 210 135 263 288 434 303 120 152 204 191 M17785 GO_TRANS_GOLGI_NETWORK_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_MEMBRANE.html The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. 45/97 Gene Ontology CC GO:0032588 0.0639781554485366 0.191855090411857 290 207.272727272727 210 0.00599256024358331 48 1.16805868303008 -0.897427101166323 -1 3.23454368181014 160 286 298 276 210 89 319 48 289 201 104 192 M17242 GO_COPI_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a COPI-coated vesicle. 11/20 Gene Ontology CC GO:0030663 0.252852301432932 0.441536647215211 330 259.545454545455 212 0.026151282534222 117 0.341062734122959 -0.357231103594851 -1 0.467645040127355 327 173 307 212 464 117 182 266 200 413 194 193 M17713 GO_SWI_SNF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_COMPLEX.html A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. 8/15 Gene Ontology CC GO:0016514 0.000999550119979004 0.013435813240648 10 239.545454545455 212 1e-04 6 1.73041933125535 1.73041933125535 1 12.508608744149 330 81 559 6 241 576 422 71 6 131 212 194 M17547 GO_CELL_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION.html A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. 241/593 Gene Ontology CC GO:0005911 2.00707107986379e-05 0.000579108118274989 215 182.727272727273 213 1.82462671882564e-06 16 1.36467064081224 1.51177536351334 1 17.0614461666764 106 97 16 213 288 334 171 213 263 87 222 195 M17304 GO_BRUSH_BORDER http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER.html The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. 61/186 Gene Ontology CC GO:0005903 0.0880450206985861 0.207714375362379 310 230.454545454545 218 0.00834360230868718 38 0.968480625771421 0.94774313697458 1 2.55286542544802 309 57 76 38 204 543 250 218 181 296 363 196 M17364 GO_LATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_PLASMA_MEMBRANE.html The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. 40/93 Gene Ontology CC GO:0016328 0.566414567027965 0.74981121140706 440 246.272727272727 218 0.0731556873100682 95 1.4471155245215 1.4471155245215 1 0.698864918210465 184 230 133 218 436 436 141 207 326 95 303 197 M17375 GO_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_COMPLEX.html A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. 18/74 Gene Ontology CC GO:0016459 0.0414620291361233 0.147716171751958 190 253.181818181818 219 0.00384224528612531 61 2.07333958077616 -2.07333958077616 -1 6.65059878972267 189 458 61 275 495 143 282 247 212 204 219 198 M17835 GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE.html A clathrin coat found on a vesicle of the trans-Golgi network. 11/16 Gene Ontology CC GO:0030130 0.236106617781693 0.419686393992002 185 224.636363636364 219 0.0241869689041276 102 1.01405746558881 -1.01405746558881 -1 1.47673809720888 181 342 310 226 336 207 235 102 219 161 152 199 M17160 GO_MICROBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY.html Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 81/169 Gene Ontology CC GO:0042579 0.0712288228999182 0.198790375109977 220 218.727272727273 220 0.00669502248160167 74 0.83074329694245 -0.804379906228381 -1 2.25098369305413 220 113 277 304 74 84 357 120 347 389 121 200 M17255 GO_MICROVILLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS.html Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. 48/118 Gene Ontology CC GO:0005902 0.0469744951646035 0.158779287749362 220 251.090909090909 220 0.00436441296604884 18 1.66826941212076 1.87042757539228 1 5.14917973622173 286 153 66 18 539 487 230 220 50 217 496 201 M17056 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. 12/18 Gene Ontology CC GO:0012510 0.198651480934908 0.375170290770743 325 232.818181818182 221 0.0199313567124052 94 1.01405746558881 -1.01405746558881 -1 1.66744785560579 180 393 325 251 323 206 249 94 221 164 155 202 M17847 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. 16/39 Gene Ontology CC GO:0000307 0.0839184282471183 0.198790375109977 225 218.818181818182 221 0.00793650793650794 31 1.39059940208002 1.39059940208002 1 3.7679709152536 123 386 221 224 467 274 116 332 31 73 160 203 M17177 GO_POSTSYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPSE.html The part of a synapse that is part of the post-synaptic cell. 184/552 Gene Ontology CC GO:0098794 0.230043669290637 0.415393089792717 210 284.545454545455 222 0.0234854113172695 98 1.21184537651845 1.26946889191234 1 1.78566984764448 246 210 98 206 222 563 411 384 220 104 466 204 M17390 GO_HISTONE_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_COMPLEX.html A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. 47/95 Gene Ontology CC GO:0035097 0.0350530918399179 0.136160192903484 125 206 223 0.00323858050328997 25 1.13115893914357 -1.13115893914357 -1 3.78293967667888 122 372 261 419 236 58 178 87 223 285 25 205 M17191 GO_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_COMPLEX.html A protein complex which is capable of protein kinase activity. 50/131 Gene Ontology CC GO:1902911 0.144624257246226 0.303973893412069 190 274.272727272727 224 0.014100949865819 122 1.39059940208002 1.39059940208002 1 2.77743005285618 305 187 264 187 122 522 472 187 170 224 377 206 M17253 GO_MOTILE_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM.html A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles. 50/165 Gene Ontology CC GO:0031514 0.0650336831609862 0.192766507010513 120 218.727272727273 225 0.00609451402040276 46 1.05222582380757 -1.05222582380757 -1 2.90541961019505 118 308 225 382 507 46 80 159 243 286 52 207 M17612 GO_CELL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX.html The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 156/408 Gene Ontology CC GO:0005938 0.0383123023500388 0.142241798862483 340 239.636363636364 226 0.00354511207554828 17 1.23580703242071 1.36157004402906 1 4.04234293210496 337 49 60 17 226 494 390 304 76 154 529 208 M17765 GO_TERMINAL_BOUTON http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINAL_BOUTON.html Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. 38/105 Gene Ontology CC GO:0043195 0.0660013837634581 0.194636733751422 265 226.090909090909 226 0.00618807652809205 67 1.9366898762468 1.9366898762468 1 5.31624993828232 263 244 168 232 67 528 214 226 103 268 174 209 M17349 GO_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE.html Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. 196/498 Gene Ontology CC GO:0005874 0.034058309767897 0.135763469281686 230 242.090909090909 227 0.00314520786262693 26 0.74589881281099 -0.687340425509773 -1 2.49816305571375 227 419 227 492 239 26 159 128 395 319 32 210 M17582 GO_RECYCLING_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a recycling endosome. 18/51 Gene Ontology CC GO:0055038 0.229822441444407 0.415393089792717 340 266.363636363636 227 0.0234599076264648 160 1.69748649654937 1.69748649654937 1 2.5012683261746 336 227 167 174 160 484 335 231 162 205 449 211 M17584 GO_SPINDLE_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MICROTUBULE.html Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. 35/78 Gene Ontology CC GO:0005876 0.236708935019711 0.419686393992002 90 263.727272727273 227 0.024256940563822 86 0.677976456359265 -0.677976456359265 -1 0.987314520260673 86 297 148 294 441 123 227 193 467 515 110 212 M17725 GO_ACTIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT.html A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. 51/112 Gene Ontology CC GO:0005884 0.00435409621627792 0.0365512216734406 300 242.272727272727 227 0.000396612501058441 19 1.28493272487013 1.33413061194856 1 7.1314830296892 298 76 37 19 532 443 548 227 45 46 394 213 M17682 GO_LYTIC_VACUOLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_MEMBRANE.html The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. 178/391 Gene Ontology CC GO:0098852 0.139457285209876 0.296346731070987 275 226.818181818182 228 0.0135610298491403 98 1.34814107358982 1.66278131653411 1 2.75008848706451 271 141 244 228 117 191 380 459 106 98 260 214 M17409 GO_CHLORIDE_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_COMPLEX.html An ion channel complex through which chloride ions pass. 8/50 Gene Ontology CC GO:0034707 0.0765897756730953 0.198790375109977 470 296.090909090909 231 0.00793650793650794 3 2.76431492756404 2.76431492756404 1 7.49019325055208 470 161 499 117 231 558 504 91 3 128 495 215 M17223 GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the rough endoplasmic reticulum. 15/30 Gene Ontology CC GO:0030867 0.199268649250204 0.375170290770743 165 278 232 0.02 11 1.01828977159174 -0.680644994905029 -1 1.67440717480912 575 11 232 162 278 186 348 452 161 185 468 216 M17344 GO_PHAGOCYTIC_CUP http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_CUP.html An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. 18/43 Gene Ontology CC GO:0001891 0.25830598937442 0.445674214502731 235 276.363636363636 232 0.0267996599700405 104 1.04458815474116 1.07200953091195 1 1.41593590933752 232 456 120 231 281 517 218 104 345 202 334 217 M17708 GO_BAF_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BAF_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family. 11/23 Gene Ontology CC GO:0090544 0.0839184282471183 0.198790375109977 290 236.181818181818 232 0.00793650793650794 15 1.73041933125535 1.73041933125535 1 4.68874767499088 289 222 263 122 407 508 280 100 15 160 232 218 M17795 GO_HISTONE_DEACETYLASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_COMPLEX.html A protein complex that possesses histone deacetylase activity. 32/70 Gene Ontology CC GO:0000118 0.0178395872475417 0.0928944272890007 450 251.727272727273 232 0.00163508278049845 25 1.70820157422404 1.70820157422404 1 6.80826125721318 448 232 320 278 25 157 578 136 178 253 164 219 M17530 GO_AXON_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_CYTOPLASM.html Any cytoplasm that is part of a axon. 20/40 Gene Ontology CC GO:1904115 0.056509719850227 0.179464934469402 45 221.909090909091 233 0.00527415311473013 41 0.802844411190204 -0.802844411190204 -1 2.3131038718753 233 310 311 364 162 90 92 43 302 493 41 220 M17825 GO_EXOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an exocytic vesicle 24/80 Gene Ontology CC GO:0099501 0.161334947490572 0.327300440926861 135 253.636363636364 233 0.0158676586014154 132 1.62371583222612 1.62371583222612 1 3.04167377761299 514 194 201 244 132 254 324 225 132 233 337 221 M17067 GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 143/347 Gene Ontology CC GO:0031300 0.00185006448021512 0.0206746751842844 175 209 234 0.000168329282236413 4 1.0154397712165 1.06762463163156 1 6.60623527748039 171 356 350 407 234 4 64 77 321 294 21 222 M17690 GO_CORNIFIED_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORNIFIED_ENVELOPE.html A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). 7/67 Gene Ontology CC GO:0001533 0.435369722646862 0.624426053821057 155 232.090909090909 236 0.0555555555555556 48 1.16751959882986 1.16751959882986 1 0.922169707979942 319 48 555 154 262 252 181 155 236 113 278 223 M17290 GO_INVADOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_INVADOPODIUM.html A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. 7/17 Gene Ontology CC GO:0071437 0.155873397674522 0.321811663327751 115 221.272727272727 238 0.0168025155707167 111 1.72130338621463 1.72130338621463 1 3.27330854370978 238 246 484 111 137 284 127 285 124 112 286 224 M17570 GO_EXOCYST http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYST.html A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. 10/21 Gene Ontology CC GO:0000145 0.156451690994979 0.321811663327751 140 246.363636363636 238 0.0153480993198813 81 0.546065117011354 -0.481449101090274 -1 1.03842217495758 138 214 238 97 216 390 245 81 284 510 297 225 M17463 GO_BLOC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_COMPLEX.html Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. 8/21 Gene Ontology CC GO:0031082 0.352119952390446 0.538426805507084 200 265.545454545455 239 0.0424764578692596 138 0.239560394089993 -0.279497448521697 -1 0.248757267236037 295 200 508 239 282 150 197 185 262 465 138 226 M17189 GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. 7/32 Gene Ontology CC GO:0032281 0.278505826203807 0.463908840189626 180 287.545454545455 240 0.032116061940393 117 0.791140711360448 -0.791140711360448 -1 1.01917864487957 176 331 462 240 449 201 166 117 439 394 188 227 M17724 GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX.html Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. 26/50 Gene Ontology CC GO:0008023 0.0839184282471183 0.198790375109977 200 249.909090909091 240 0.00793650793650794 48 1.1831583752295 -0.635897419203641 -1 3.20588829401496 307 350 336 316 200 163 184 405 48 240 200 228 M16974 GO_FILOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM.html Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. 78/172 Gene Ontology CC GO:0030175 0.195271134650426 0.374299238535247 530 270.818181818182 242 0.0195562349403073 93 1.11088870756338 1.09389744067675 1 1.83100163559487 527 211 93 170 221 281 352 242 183 273 426 229 M17369 GO_PLATELET_DENSE_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet dense granule. 7/15 Gene Ontology CC GO:0031089 0.0600444469272867 0.184604735765807 70 248.636363636364 242 0.0061731362949196 64 0.703675739223125 0.968574201799346 1 1.99405887822306 242 64 493 67 66 349 139 365 156 435 359 230 M17791 GO_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a transport vesicle. 81/216 Gene Ontology CC GO:0030658 0.232850105696956 0.415393089792717 345 277.727272727273 242 0.0238095238095238 143 1.20854257582997 1.25716385339027 1 1.78080312806478 342 325 197 242 173 223 417 469 143 231 293 231 M17271 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. 11/48 Gene Ontology CC GO:0034364 0.361245384592355 0.546596419618799 245 268.454545454545 244 0.0399295658887627 72 1.20555776449092 -1.20555776449092 -1 1.22138998780707 244 72 155 143 465 477 100 540 268 158 331 232 M17806 GO_GOLGI_CISTERNA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA_MEMBRANE.html The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. 38/86 Gene Ontology CC GO:0032580 0.118770271841362 0.262019912688195 245 296 244 0.0114284595353182 107 0.675133943148694 0.675133943148694 1 1.51661883638708 409 225 195 338 107 204 244 280 444 566 244 233 M17224 GO_AXON_INITIAL_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_INITIAL_SEGMENT.html Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. 7/26 Gene Ontology CC GO:0043194 0.0290209049651676 0.123338846101962 95 221.454545454545 245 0.00294070166511243 25 0.397029013337559 0.509112629087471 1 1.39364271957192 93 371 471 329 245 93 25 29 333 407 40 234 M17489 GO_MITOCHONDRIAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PART.html Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 580/1145 Gene Ontology CC GO:0044429 0.0225239268254811 0.104150637641025 150 245.090909090909 246 0.0022755534930225 37 0.946980187841282 1.07690809760014 1 3.59265003159454 146 139 517 438 37 130 257 246 279 328 179 235 M17129 GO_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. 174/423 Gene Ontology CC GO:0030139 0.00695643272434379 0.0502602264333839 405 284.090909090909 247 0.000634411539754221 40 1.3130030165982 1.38432799472181 1 6.58586582124619 405 247 40 113 155 454 400 527 177 53 554 236 M17832 GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the nucleus. 24/47 Gene Ontology CC GO:0000152 0.026416896279766 0.115673985225036 105 291.727272727273 247 0.00243086718156309 27 0.26229970914037 -0.277699009143634 -1 0.9489453151455 104 457 247 446 556 67 91 27 527 575 112 237 M17336 GO_CONTRACTILE_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_FIBER.html Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. 110/299 Gene Ontology CC GO:0043292 2.60437514182484e-05 0.000684240378170344 230 292.545454545455 248 2.36764179373454e-06 18 2.24851534355468 -2.59443856790082 -1 27.4823571364263 569 248 18 291 229 238 381 339 217 228 460 238 M17498 GO_PRP19_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRP19_COMPLEX.html A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. 12/20 Gene Ontology CC GO:0000974 0.00515526987731749 0.0397299465211934 250 265.727272727273 248 0.000469762729520573 11 0.243311861697777 -0.285070786058911 -1 1.31636973385203 248 189 323 184 11 234 327 284 493 479 151 239 M17799 GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX.html Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. 5/14 Gene Ontology CC GO:0005890 0.214139132665174 0.391900034560824 55 269.363636363636 249 0.0238095238095238 54 1.38933387508025 1.38933387508025 1 2.18286552633746 249 54 573 55 427 312 367 544 117 94 171 240 M17012 GO_IMMUNOLOGICAL_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE.html An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 20/68 Gene Ontology CC GO:0001772 0.0834700819408183 0.198790375109977 530 291.909090909091 250 0.00789237837244853 36 0.633042077535849 0.633042077535849 1 1.71529207354527 205 527 172 429 382 190 36 250 529 344 147 241 M17442 GO_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COMPLEX.html A protein complex which is capable of ATPase activity. 15/33 Gene Ontology CC GO:1904949 0.514011397665828 0.702360727779784 540 341.454545454545 250 0.0634920634920635 149 1.38933387508025 1.38933387508025 1 0.823299091071259 550 154 149 166 573 460 539 191 250 186 538 242 M17172 GO_LIPID_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE.html An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. 41/94 Gene Ontology CC GO:0005811 0.298735036746822 0.485024863032761 180 258.181818181818 251 0.0317460317460317 114 1.44396892550962 1.44396892550962 1 1.75237411243047 179 251 129 259 352 472 403 114 169 189 323 243 M17137 GO_MALE_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GERM_CELL_NUCLEUS.html The nucleus of a male germ cell, a reproductive cell in males. 12/33 Gene Ontology CC GO:0001673 0.583892952280515 0.765283733374462 255 309 253 0.0766161398477646 185 0.291726744520362 -0.310506160696843 -1 0.130891476571726 185 252 253 299 394 197 252 454 520 384 209 244 M17008 GO_CELL_CELL_CONTACT_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_CONTACT_ZONE.html Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. 48/126 Gene Ontology CC GO:0044291 0.449308880336461 0.639656484813977 125 312.909090909091 254 0.0527901873886002 119 1.54945044865485 1.54945044865485 1 1.1612120402439 254 122 119 123 423 575 414 557 244 215 396 245 M17165 GO_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_NUCLEUS.html The nucleus of a germ cell, a reproductive cell in multicellular organisms. 12/37 Gene Ontology CC GO:0043073 0.583892952280515 0.765283733374462 255 310.454545454545 254 0.0766161398477646 186 0.291726744520362 -0.310506160696843 -1 0.130891476571726 186 253 254 300 395 198 253 455 521 390 210 246 M17655 GO_ACTIN_BASED_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BASED_CELL_PROJECTION.html A cell projection supported by an assembly of actin filaments, and which lacks microtubules. 120/302 Gene Ontology CC GO:0098858 0.0350543319225827 0.136160192903484 520 279 254 0.00323869695503639 46 1.34976615237368 1.40450949456296 1 4.51402871571228 520 159 59 46 254 304 412 551 63 243 458 247 M17771 GO_RECYCLING_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME.html An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. 72/172 Gene Ontology CC GO:0055037 0.0343570858182949 0.136016408239551 375 294.363636363636 254 0.00317324251367306 42 1.39394498506959 1.39394498506959 1 4.66424639032944 371 131 170 179 42 502 383 470 254 200 536 248 M17113 GO_T_CELL_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_COMPLEX.html A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. 6/24 Gene Ontology CC GO:0042101 0.0482315249737907 0.161143476502029 380 270.272727272727 255 0.00493114899442743 27 0.371806957961297 0.382021961172803 1 1.13837992023018 164 260 452 246 559 194 27 255 380 378 58 249 M17158 GO_APICAL_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_COMPLEX.html A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. 77/174 Gene Ontology CC GO:0043296 0.0195911890854789 0.0956504690311516 220 271.545454545455 255 0.00179707789178908 51 1.26426716222551 -0.96026125062569 -1 4.97690583245271 190 218 51 337 255 441 228 305 357 218 387 250 M17262 GO_CELL_CORTEX_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_REGION.html The complete extent of cell cortex that underlies some some region of the plasma membrane 8/25 Gene Ontology CC GO:0099738 0.0646086026924058 0.19249367193923 145 254.363636363636 257 0.00665676795440087 50 1.29994081892301 1.29994081892301 1 3.59250161393028 141 337 479 257 549 373 104 50 269 125 114 251 M17848 GO_VACUOLAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_MEMBRANE.html The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. 371/795 Gene Ontology CC GO:0005774 0.304014557947339 0.489471906667304 335 273.272727272727 258 0.0324109982727215 118 1.27678281263012 1.57002425124034 1 1.52993500022323 331 301 258 344 187 140 405 422 253 118 247 252 M17021 GO_SPERM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PART.html Any constituent part of a sperm, a mature male germ cell that develops from a spermatid. 70/232 Gene Ontology CC GO:0097223 0.0106512405920872 0.065344509088875 500 253.272727272727 259 0.000973014595013542 18 1.98577082557803 1.98577082557803 1 9.08623328713644 498 152 97 79 18 286 509 346 53 259 489 253 M17532 GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 65/154 Gene Ontology CC GO:0044798 0.0495707456288643 0.164666040077492 555 255 259 0.00461129425094343 57 1.73041933125535 1.73041933125535 1 5.23535013018889 552 212 262 290 57 98 259 241 300 303 231 254 M17824 GO_SYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_MEMBRANE.html A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 103/356 Gene Ontology CC GO:0097060 0.514011397665828 0.702360727779784 145 285.545454545455 259 0.0634920634920635 143 1.34544206054545 -1.44391152238049 -1 0.797289438592229 157 417 143 358 247 438 170 399 259 145 408 255 M16976 GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. 82/187 Gene Ontology CC GO:0000784 0.126362880562091 0.275033034423377 30 256.454545454545 260 0.0122058230695271 29 1.33403223803043 -1.33403223803043 -1 2.88831258948258 29 389 249 443 260 229 301 127 277 306 211 256 M17100 GO_MRNA_CLEAVAGE_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_FACTOR_COMPLEX.html Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. 13/20 Gene Ontology CC GO:0005849 0.0394988320192993 0.142241798862483 260 261.545454545455 260 0.00365694075119271 8 1.64556252057147 1.64556252057147 1 5.38265914681755 256 359 213 260 264 495 535 31 8 169 287 257 M17110 GO_SCF_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). 15/37 Gene Ontology CC GO:0019005 0.00908474349992657 0.0589997948646917 230 232.272727272727 260 0.000829316056885916 16 0.3564540416128 -0.3585611828975 -1 1.69208157887915 333 95 260 229 16 153 229 300 267 375 298 258 M17277 GO_PARANODE_REGION_OF_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARANODE_REGION_OF_AXON.html An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. 6/35 Gene Ontology CC GO:0033270 0.33296556889208 0.520146213026006 265 270.909090909091 261 0.0396825396825397 57 0.931951048591966 -0.931951048591966 -1 1.02172170392797 261 77 482 57 393 244 151 360 186 422 347 259 M17462 GO_NEURON_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION.html A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 512/1429 Gene Ontology CC GO:0043005 0.0765897756730953 0.198790375109977 510 301.636363636364 262 0.00793650793650794 49 1.32280959582958 1.53233244417765 1 3.58428752065701 376 262 507 205 118 218 514 509 80 49 480 260 M16979 GO_I_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_BAND.html A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. 65/198 Gene Ontology CC GO:0031674 0.00364998090127314 0.0340272413054173 280 301.818181818182 263 0.000332368238421734 36 1.90259211920853 1.90259211920853 1 10.7878785971794 277 263 36 196 215 537 473 396 237 252 438 261 M17602 GO_NONMOTILE_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM.html A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 70/208 Gene Ontology CC GO:0031513 0.0839184282471183 0.198790375109977 465 249 263 0.00793650793650794 28 1.62594231787846 1.87461225339986 1 4.4056565505896 462 60 184 109 274 263 369 307 28 119 564 262 M17237 GO_PCG_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PCG_PROTEIN_COMPLEX.html A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. 33/52 Gene Ontology CC GO:0031519 0.214256766299689 0.391900034560824 445 262.363636363636 264 0.0216819663761337 97 1.13115893914357 -1.13115893914357 -1 1.77723144583605 101 397 295 444 444 97 140 264 330 256 118 263 M17585 GO_GOLGI_TRANSPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TRANSPORT_COMPLEX.html A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). 3/12 Gene Ontology CC GO:0017119 0.00956098650837432 0.0608281357887052 295 274.636363636364 265 0.00096023729444135 14 0.319162323954465 -0.379786188980158 -1 1.49872141595463 294 168 539 265 459 220 123 14 325 516 98 264 M17610 GO_PHOTORECEPTOR_INNER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_INNER_SEGMENT.html The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. 21/55 Gene Ontology CC GO:0001917 0.514011397665828 0.702360727779784 475 318.090909090909 265 0.0634920634920635 97 1.04920513629886 1.25817641655187 1 0.621743735303942 475 213 166 253 244 297 506 414 265 97 569 265 M17169 GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. 35/63 Gene Ontology CC GO:0030660 0.32553958874993 0.515446692831116 270 299.636363636364 266 0.0351704692506881 142 1.01405746558881 -1.01405746558881 -1 1.12717386630209 266 482 347 479 195 142 267 232 448 262 176 266 M17731 GO_CILIARY_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PLASM.html All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. 34/119 Gene Ontology CC GO:0097014 0.437501692384064 0.625930639103933 355 292.909090909091 266 0.0509616828766725 150 1.19630637093633 -0.900270877697453 -1 0.940078095648622 352 434 266 394 443 162 224 150 291 258 248 267 M17818 GO_GAP_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION.html A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons. 11/35 Gene Ontology CC GO:0005921 0.083498086502072 0.198790375109977 90 307.454545454545 266 0.007895134214099 74 0.48409353466943 0.467035945033364 1 1.31170080389561 88 411 74 399 505 266 147 194 475 569 254 268 M17451 GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. 37/89 Gene Ontology CC GO:0012507 0.232850105696956 0.415393089792717 365 291.363636363636 267 0.0238095238095238 130 1.13497986044498 1.13497986044498 1 1.67240751444232 365 231 178 194 190 298 416 547 130 267 389 269 M17153 GO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAJAL_BODY.html A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. 28/64 Gene Ontology CC GO:0015030 0.078798620724566 0.198790375109977 390 251 268 0.00743374238165029 81 0.691794135926133 -0.691794135926133 -1 1.87448676846439 87 319 360 390 81 192 268 200 331 387 146 270 M17445 GO_LATE_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME.html A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. 132/279 Gene Ontology CC GO:0005770 0.415320710913563 0.605961617453683 535 325.818181818182 268 0.0476190476190476 99 1.62286706361644 1.81900390284881 1 1.36353041249116 531 268 214 237 300 225 566 543 216 99 385 271 M17001 GO_CENTRIOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE.html A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. 54/137 Gene Ontology CC GO:0005814 0.0709274049409663 0.198790375109977 50 246 269 0.00666572122367959 48 0.743128926420273 -0.743128926420273 -1 2.01358361945748 115 269 283 349 531 48 61 183 476 341 50 272 M17144 GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE.html The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 75/180 Gene Ontology CC GO:0031227 0.000337594673266602 0.00542027003189155 340 187.363636363636 269 3.06951353653101e-05 2 1.24784257041718 1.24784257041718 1 10.9201534286295 68 294 338 296 325 2 3 116 340 269 10 273 M17448 GO_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases. 14/25 Gene Ontology CC GO:0000178 0.298735036746822 0.485024863032761 530 330.454545454545 269 0.0317460317460317 167 1.51341879904055 1.51341879904055 1 1.83665720103615 528 203 269 210 246 387 433 514 167 179 499 274 M17272 GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. 2/14 Gene Ontology CC GO:0017146 0.107565158238813 0.245741744909226 270 290 269.5 0.0125650340117286 50 0.47057805723914 -0.47057805723914 -1 1.10772876923687 269 270 481 NA 508 200 50 171 418 420 113 275 M17229 GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM.html The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. 8/22 Gene Ontology CC GO:0097038 0.0805003557233664 0.198790375109977 280 242.090909090909 270 0.00835744294587622 62 0.463346694995434 -0.453729068853417 -1 1.25548512562103 280 62 473 98 87 270 291 135 369 409 189 276 M17341 GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS.html A cell part consisting of multiple, closely packed actin-based cell projections. 75/238 Gene Ontology CC GO:0098862 0.0426133546274589 0.148316599094393 510 250.363636363636 270 0.0039510785016772 35 1.32764748612994 1.40188608462194 1 4.24962818041459 510 51 63 35 165 280 496 356 57 270 471 277 M17081 GO_PLATELET_ALPHA_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_MEMBRANE.html The lipid bilayer surrounding the platelet alpha granule. 10/16 Gene Ontology CC GO:0031092 0.166962560195521 0.335305125145301 335 287.272727272727 272 0.0164698364327589 57 0.392503273990265 0.410953565299399 1 0.719361650313852 153 335 88 332 545 242 57 263 504 369 272 278 M17467 GO_CATALYTIC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_COMPLEX.html A protein complex which is capable of catalytic activity. 557/1220 Gene Ontology CC GO:1902494 0.0538056667300237 0.174717277359291 275 292.636363636364 272 0.00551546414160976 44 1.01045776825986 -0.785273911978439 -1 2.9567046896235 272 463 510 554 224 44 266 170 323 327 66 279 M17407 GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE.html The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 26/65 Gene Ontology CC GO:0031228 0.43119990772354 0.623083866660516 485 265.909090909091 273 0.05 35 0.832048707356396 -1.0296882537552 -1 0.660199702879671 482 35 139 151 273 332 354 277 270 239 373 280 M17382 GO_SIN3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_COMPLEX.html A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. 8/19 Gene Ontology CC GO:0016580 0.0765897756730953 0.198790375109977 530 258.363636363636 274 0.00793650793650794 10 1.70820157422404 1.70820157422404 1 4.62854639610306 530 87 495 62 346 313 542 56 10 127 274 281 M17078 GO_COPI_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_VESICLE_COAT.html One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. 9/13 Gene Ontology CC GO:0030126 0.33296556889208 0.520146213026006 200 292.363636363636 276 0.0396825396825397 194 0.355363835951992 -0.389440434675869 -1 0.389594433276365 433 199 446 198 349 230 242 276 194 368 281 282 M17495 GO_RESPIRATORY_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN.html The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. 44/93 Gene Ontology CC GO:0070469 0.151695798295736 0.316534914855363 480 280.363636363636 276 0.0148447126455752 47 0.564322045552235 -0.564322045552235 -1 1.0887889286074 47 409 402 476 276 86 93 216 485 477 117 283 M17813 GO_CENTRIOLAR_SATELLITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLAR_SATELLITE.html A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. 10/33 Gene Ontology CC GO:0034451 0.286640294286233 0.472322636745494 295 289.090909090909 276 0.0302396668538985 144 0.353749492592993 -0.266230522828548 -1 0.44504945798426 292 198 276 144 178 296 413 433 190 568 192 284 M17719 GO_EXTRINSIC_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 140/326 Gene Ontology CC GO:0019898 0.327731083343857 0.516154131260897 280 251.909090909091 277 0.0354558890666877 131 1.17591383215896 1.41677035668314 1 1.3043799600227 338 184 141 279 277 131 279 376 303 265 198 285 M17684 GO_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENVELOPE.html A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. 635/1396 Gene Ontology CC GO:0031975 0.0579979531197859 0.18130078120001 270 298.909090909091 278 0.00595696962804316 64 1.1529735582344 1.21149012033956 1 3.30219188199721 270 396 553 506 64 146 337 236 278 312 190 286 M17740 GO_CELL_LEADING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_LEADING_EDGE.html The area of a motile cell closest to the direction of movement. 234/544 Gene Ontology CC GO:0031252 0.059845209900187 0.184604735765807 310 256 279 0.00559436086037931 70 1.20009582882671 1.31033638523624 1 3.40080183484816 310 279 70 95 139 475 409 309 115 105 510 287 M17028 GO_NUCLEOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOID.html The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. 39/68 Gene Ontology CC GO:0009295 0.204862616989027 0.382708760910448 350 239.090909090909 280 0.0206243808432319 61 0.649377231623623 -0.627160801760922 -1 1.04612405699644 61 280 346 297 350 102 188 113 446 350 97 288 M17599 GO_SUPRAMOLECULAR_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPRAMOLECULAR_FIBER.html A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. 288/821 Gene Ontology CC GO:0099512 0.0392171649259014 0.142241798862483 400 263.454545454545 280 0.00363038267901134 33 1.07473251324826 1.34243691739044 1 3.51546581619812 398 424 64 470 310 33 196 354 247 280 122 289 M17764 GO_BRUSH_BORDER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER_MEMBRANE.html The portion of the plasma membrane surrounding the brush border. 27/96 Gene Ontology CC GO:0031526 0.353469205108082 0.539063853700453 395 322.545454545455 280 0.0388728668884677 107 1.03069309216194 -1.03069309216194 -1 1.06821789986253 394 259 107 327 280 540 270 221 375 247 528 290 M17650 GO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. 102/223 Gene Ontology CC GO:0000781 0.350018015444289 0.53805960884787 310 283.363636363636 281 0.0384075848376157 62 1.33403223803043 -1.33403223803043 -1 1.38677304998645 62 440 281 491 269 245 307 166 322 308 226 291 M17058 GO_INTERCALATED_DISC http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCALATED_DISC.html A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. 41/108 Gene Ontology CC GO:0014704 0.46422875003706 0.653606363325543 570 321.090909090909 283 0.05515240032437 121 1.54945044865485 1.54945044865485 1 1.10514527317112 567 258 121 181 554 283 340 324 276 188 440 292 M16996 GO_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_COMPLEX.html A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. 47/87 Gene Ontology CC GO:0000502 0.265974926453458 0.454832862396741 120 295.909090909091 284 0.0277187748410517 116 0.201569841993394 -0.227413548756584 -1 0.266350065350612 116 488 408 520 284 119 179 199 456 338 148 293 M17054 GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of H4 histone acetyltransferase activity. 18/27 Gene Ontology CC GO:1902562 0.351540567143305 0.538426805507084 285 317.727272727273 285 0.0386125744866153 137 0.84157669908996 -0.84157669908996 -1 0.873885368842258 284 503 189 556 432 137 315 239 285 359 196 294 M16993 GO_NUCLEAR_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE.html The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). 223/592 Gene Ontology CC GO:0005635 0.102486220574698 0.236004125466833 480 289.454545454545 286 0.00978155591423992 95 1.4072749576851 1.40412125748263 1 3.4081228148774 480 316 286 469 95 121 557 382 116 177 185 295 M17767 GO_AXONEMAL_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX.html A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 3/21 Gene Ontology CC GO:0005858 0.202400735028754 0.379829950800713 345 328.454545454545 286 0.0223610981989822 97 0.364964484472017 -0.510237172402214 -1 0.592567057543457 344 275 569 219 384 446 286 97 231 556 206 296 M17103 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX.html A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. 51/124 Gene Ontology CC GO:0090575 0.167072449899389 0.335305125145301 485 321.454545454545 287 0.0164816318558465 135 1.73041933125535 1.73041933125535 1 3.17143166991167 483 326 273 353 135 265 459 197 242 287 516 297 M17389 GO_ENDOCYTIC_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_LUMEN.html The volume enclosed by the membrane of an endocytic vesicle. 12/38 Gene Ontology CC GO:0071682 0.318969886124623 0.507891444022127 290 313.909090909091 288 0.0343198564865154 104 0.546934770824936 0.580630117743677 1 0.621490086644207 288 157 104 197 345 572 211 474 287 440 378 298 M17412 GO_CLATHRIN_COAT_OF_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_COATED_PIT.html The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. 12/22 Gene Ontology CC GO:0030132 0.63389956273523 0.812403430733842 400 291.272727272727 289 0.0873015873015873 165 1.21455215107271 1.21455215107271 1 0.423225424482925 209 399 289 323 416 399 183 282 298 165 241 299 M17510 GO_POLE_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLE_PLASM.html Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. 8/18 Gene Ontology CC GO:0045495 0.0392939113641999 0.142241798862483 505 282.727272727273 289 0.0040006515733681 22 1.51341879904055 1.51341879904055 1 4.95041509454219 501 197 523 202 52 342 289 368 22 129 485 300 M17112 GO_BLOC_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_1_COMPLEX.html A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. 4/16 Gene Ontology CC GO:0031083 0.481063017846562 0.670010661000754 345 330.363636363636 290 0.0634920634920635 193 0.254915840766944 -0.247492294281248 -1 0.171220241566857 345 237 451 261 458 290 559 212 251 377 193 301 M17388 GO_U5_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U5_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U5. 6/20 Gene Ontology CC GO:0005682 0.0229951580093464 0.104699817056242 170 270.818181818182 290 0.00232366320256963 24 0.169249061745536 -0.169249061745536 -1 0.640603567698184 168 290 496 366 577 69 39 24 481 439 30 302 M17603 GO_NUCLEAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MATRIX.html The dense fibrillar network lying on the inner side of the nuclear membrane. 54/158 Gene Ontology CC GO:0016363 0.0839184282471183 0.198790375109977 195 304.454545454545 290 0.00793650793650794 87 2.76431492756404 2.76431492756404 1 7.49019325055208 193 403 248 432 446 541 157 190 87 290 362 303 M17752 GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. 11/23 Gene Ontology CC GO:0033176 0.545568246612136 0.733366446678214 275 304.727272727273 290 0.069190540579131 183 0.801505046067566 -0.801505046067566 -1 0.416887687907117 245 299 259 273 290 273 332 290 355 553 183 304 M17306 GO_PLATELET_DENSE_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_TUBULAR_NETWORK.html A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. 8/14 Gene Ontology CC GO:0031094 0.275742742869669 0.460633830574186 295 293.090909090909 291 0.0317460317460317 30 1.69748649654937 1.69748649654937 1 2.20693971991042 291 30 485 49 366 501 256 575 159 126 386 305 M17425 GO_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLTRANSFERASE_COMPLEX.html A protein complex that possesses methyltransferase activity. 57/119 Gene Ontology CC GO:0034708 0.308795533887325 0.493049222615674 175 286.363636363636 292 0.0330171404774446 124 1.13115893914357 -1.13115893914357 -1 1.34162221804043 174 461 280 508 296 173 398 140 304 292 124 306 M17688 GO_WASH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_WASH_COMPLEX.html A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. 5/11 Gene Ontology CC GO:0071203 0.153306252370032 0.318744654208196 265 313.545454545455 292 0.0165039154266006 85 0.97975757930076 -0.97975757930076 -1 1.87888788185675 262 292 554 256 332 176 401 85 397 540 154 307 M17800 GO_SITE_OF_DOUBLE_STRAND_BREAK http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_DOUBLE_STRAND_BREAK.html A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. 22/46 Gene Ontology CC GO:0035861 0.704607640910132 0.862845797555204 365 316.090909090909 292 0.104935200285407 167 0.9282856402567 -0.9282856402567 -1 0.229682433547546 167 281 292 362 361 243 299 287 406 563 216 308 M17171 GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the cytoplasm. 11/18 Gene Ontology CC GO:0000177 0.298735036746822 0.485024863032761 415 330.727272727273 293 0.0317460317460317 157 1.51341879904055 1.51341879904055 1 1.83665720103615 413 209 229 195 293 526 531 447 165 157 473 309 M17131 GO_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INCLUSION_BODY.html A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. 43/96 Gene Ontology CC GO:0016234 0.255072613911321 0.444072201327541 515 331.272727272727 294 0.0264147298629646 166 1.06745192347546 1.22961342200306 1 1.45337494687301 511 362 257 281 166 199 495 464 337 278 294 310 M17235 GO_GOLGI_CISTERNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA.html Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. 61/145 Gene Ontology CC GO:0031985 0.281078019336104 0.465510301364665 330 283.636363636364 295 0.0295546815416723 122 1.08295103344068 1.08295103344068 1 1.38884067939018 328 378 198 397 181 122 278 345 403 295 195 311 M17581 GO_DESMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DESMOSOME.html A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. 14/36 Gene Ontology CC GO:0030057 0.652205072410304 0.83034037853118 295 320.909090909091 295 0.0915477328917475 180 0.924082296867444 -0.680644994905029 -1 0.288159605579267 379 283 239 295 375 210 388 532 354 180 295 312 M17128 GO_SITE_OF_POLARIZED_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_POLARIZED_GROWTH.html Any part of a cell where non-isotropic growth takes place. 108/272 Gene Ontology CC GO:0030427 0.093373791982708 0.219390454333355 310 275.909090909091 296 0.00887177807993193 50 1.30360379346212 1.40344156341407 1 3.31665704607535 308 296 77 140 225 570 397 328 111 50 533 313 M17232 GO_ORGANELLE_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. 301/618 Gene Ontology CC GO:0019866 0.269519039043183 0.458182366373411 145 317 296 0.0281464862754543 145 0.921731630916169 0.999652089141994 1 1.20661320816795 145 520 424 571 175 196 296 254 367 326 213 314 M17367 GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 18/32 Gene Ontology CC GO:0031312 0.21405205051695 0.391900034560824 445 327.909090909091 296 0.0216587974116434 153 1.16169696582763 -0.967459383376804 -1 1.82521156570855 444 272 228 266 153 329 534 491 391 203 296 315 M17738 GO_MITOCHONDRIAL_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ENVELOPE.html The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. 426/833 Gene Ontology CC GO:0005740 0.0693587029039603 0.198790375109977 235 287.909090909091 296 0.0065133649068876 71 1.04132722222981 1.15505078336151 1 2.82158231818305 235 361 422 486 71 174 302 296 281 321 218 316 M17597 GO_INHIBITORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INHIBITORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. 6/20 Gene Ontology CC GO:0060077 0.271482545441946 0.460166895206582 365 315.909090909091 298 0.0311779911925522 102 1.22554810741938 -1.22554810741938 -1 1.59544691107274 362 538 541 298 562 331 131 112 210 102 288 317 M17642 GO_NUCLEAR_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PERIPHERY.html The portion of the nuclear lumen proximal to the inner nuclear membrane. 61/182 Gene Ontology CC GO:0034399 0.0839184282471183 0.198790375109977 255 339.454545454545 298 0.00793650793650794 89 2.76431492756404 2.76431492756404 1 7.49019325055208 252 418 265 471 439 549 248 259 89 298 446 318 M17768 GO_MAST_CELL_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_GRANULE.html Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. 9/48 Gene Ontology CC GO:0042629 0.559118275212016 0.744632172978215 190 346.727272727273 298 0.0786339412136061 130 0.389018570506698 0.461857748338175 1 0.192393667012564 188 437 570 463 298 256 130 188 472 557 255 319 M17391 GO_MICROTUBULE_PLUS_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_PLUS_END.html The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. 11/22 Gene Ontology CC GO:0035371 0.84237281551461 0.96033823938352 265 371.090909090909 299 0.154609478164313 171 0.224484461871989 -0.224484461871989 -1 0.0152375000317917 255 555 171 512 504 261 264 299 549 441 271 320 M17605 GO_MICROTUBULE_ASSOCIATED_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ASSOCIATED_COMPLEX.html Any multimeric complex connected to a microtubule. 62/174 Gene Ontology CC GO:0005875 0.187518689035582 0.365542470081863 95 294.090909090909 299 0.0187013161424211 92 1.10861799449966 -0.708329498464269 -1 1.87127741173729 324 541 179 504 440 92 260 93 400 299 103 321 M17838 GO_CHYLOMICRON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHYLOMICRON.html A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. 5/15 Gene Ontology CC GO:0042627 0.272893613369662 0.460633830574186 580 330.545454545455 299 0.0313658064150697 184 0.595961807216201 0.736809310569898 1 0.774823116495277 222 215 577 305 184 410 185 273 390 576 299 322 M17156 GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. 7/15 Gene Ontology CC GO:0016471 0.545584034726007 0.733366446678214 355 308.090909090909 300 0.0758438496514952 173 0.259899142030446 -0.205792731368525 -1 0.135181618356813 332 274 458 354 268 300 247 173 352 388 243 323 M17282 GO_APICAL_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_DENDRITE.html A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. 9/30 Gene Ontology CC GO:0097440 0.147859119791321 0.309646997244144 345 288.727272727273 301 0.0158730158730159 93 1.86280643978199 1.86280643978199 1 3.66279095506199 343 344 483 156 320 491 297 211 93 137 301 324 M17833 GO_ORGANELLE_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_SUBCOMPARTMENT.html A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. 187/420 Gene Ontology CC GO:0031984 0.187830646391546 0.365542470081863 415 288.545454545455 301 0.0187355744724972 144 1.10518902800255 1.17444300361462 1 1.8654895320497 311 339 284 414 146 144 415 267 356 301 197 325 M17286 GO_ORGANELLAR_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_RIBOSOME.html A ribosome contained within a subcellular membrane-bounded organelle. 52/80 Gene Ontology CC GO:0000313 0.464018474295393 0.653606363325543 80 310.090909090909 302 0.055118694777115 80 0.657812056363 -0.564322045552235 -1 0.469184335743587 80 302 410 405 294 267 284 313 353 423 280 326 M17313 GO_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 149/357 Gene Ontology CC GO:0005667 0.0207906326518505 0.0984998825636853 260 320.272727272727 302 0.00190815904911219 30 1.18058107478769 1.21653263882453 1 4.58934156501232 397 267 256 431 30 356 442 256 245 302 541 327 M17227 GO_ACTIN_FILAMENT_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE.html An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. 46/106 Gene Ontology CC GO:0032432 0.0633638868102706 0.191750400923227 365 330.818181818182 303 0.00593327593023244 72 1.2335167790473 1.2335167790473 1 3.41693700368159 363 303 72 215 243 412 530 487 255 283 476 328 M17822 GO_PLATELET_DENSE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE.html Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. 13/31 Gene Ontology CC GO:0042827 0.268295110188541 0.45744712002648 440 308.636363636364 305 0.0279985669675603 101 0.50602420424945 0.687767655046534 1 0.663785240752461 251 134 101 178 213 419 305 436 348 571 439 329 M17821 GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX.html A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. 6/13 Gene Ontology CC GO:0036513 0.131924619990146 0.282416408719646 205 333.454545454545 306 0.0140480644519208 72 0.259334014344709 -0.240616380969475 -1 0.549961055562174 306 291 575 403 331 202 217 72 500 570 201 330 M16988 GO_CYTOCHROME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX.html A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 7/29 Gene Ontology CC GO:0070069 0.335167364008499 0.520876120974632 200 293.272727272727 307 0.04 31 0.396596977915645 0.547331299407067 1 0.433866586590314 199 31 430 54 311 552 265 533 209 335 307 331 M17586 GO_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MEMBRANE.html The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. 121/257 Gene Ontology CC GO:0019867 0.0839184282471183 0.198790375109977 440 304 308 0.00793650793650794 32 1.34665172828402 1.34665172828402 1 3.64889021044009 436 32 308 155 129 320 516 523 84 304 537 332 M17348 GO_CYTOSKELETAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PART.html Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. 685/1737 Gene Ontology CC GO:0044430 0.0640623398780075 0.191855090411857 425 307.545454545455 310 0.00659877256090566 47 1.23008019321049 1.42923036535021 1 3.40629128932932 424 439 490 467 238 47 310 331 229 276 132 333 M17653 GO_TOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_COMPLEX.html A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. 7/17 Gene Ontology CC GO:0038201 0.275742742869669 0.460633830574186 235 338 311 0.0317460317460317 160 0.90126246461125 0.90126246461125 1 1.17175125140044 234 205 549 172 369 385 294 506 160 533 311 334 M17048 GO_OXIDOREDUCTASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_COMPLEX.html Any protein complex that possesses oxidoreductase activity. 56/106 Gene Ontology CC GO:1990204 0.126572296118717 0.275033034423377 85 254.272727272727 312 0.0122273508354629 75 0.629639554558714 -0.629639554558714 -1 1.36323230901925 82 312 378 408 360 75 79 238 428 355 82 335 M17057 GO_ENDOSOME_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_LUMEN.html The volume enclosed by the membrane of an endosome. 22/42 Gene Ontology CC GO:0031904 0.121949624047549 0.266995767801073 420 294.272727272727 312 0.0117532312428721 70 1.08805712363341 -1.23435683890907 -1 2.40987685410478 416 70 102 85 109 464 312 570 318 229 562 336 M17133 GO_ANAPHASE_PROMOTING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX.html A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. 11/24 Gene Ontology CC GO:0005680 0.79990999945498 0.934036322595916 355 328.545454545455 312 0.136077002451254 234 0.275933903725135 -0.261266750556583 -1 0.0315821038779686 312 353 234 372 303 268 254 252 532 381 353 337 M17003 GO_MICROTUBULE_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. 567/1355 Gene Ontology CC GO:0015630 0.0580287967508683 0.18130078120001 265 314.363636363636 313 0.00596022443501181 45 1.11986182319079 -0.741590331200168 -1 3.20735770121984 265 415 433 544 487 45 231 297 328 313 100 338 M17579 GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX.html A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. 13/27 Gene Ontology CC GO:0032806 0.0839184282471183 0.198790375109977 490 288.545454545455 313 0.00793650793650794 9 1.73041933125535 1.73041933125535 1 4.68874767499088 488 374 313 193 223 415 351 144 9 172 492 339 M17325 GO_RIBONUCLEOPROTEIN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_GRANULE.html A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. 98/225 Gene Ontology CC GO:0035770 0.403772126127339 0.595357879851026 370 321 314 0.0459240814237639 155 1.17435032262833 1.1774722762296 1 1.02145990139602 366 530 251 518 314 155 350 322 293 198 234 340 M17431 GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of an organellar ribosome. 19/29 Gene Ontology CC GO:0000314 0.0839184282471183 0.198790375109977 365 279.454545454545 314 0.00793650793650794 41 0.751302067173766 0.751302067173766 1 2.03572957798952 200 147 400 203 248 314 363 361 41 452 345 341 M17639 GO_CONDENSED_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. 135/358 Gene Ontology CC GO:0000793 0.591511385807231 0.773514889132533 315 351.727272727273 314 0.078165997661217 105 0.953543073755533 -1.00419156262766 -1 0.410724120528239 105 487 211 537 448 275 374 311 501 314 306 342 M17311 GO_EARLY_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding an early endosome. 84/194 Gene Ontology CC GO:0031901 0.667434366415499 0.835015289584759 295 345.272727272727 315 0.0952380952380952 163 1.20752266462437 1.34317708917762 1 0.365174967555215 293 377 191 359 285 546 295 480 315 163 494 343 M17350 GO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON.html Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. 951/2385 Gene Ontology CC GO:0005856 0.0196927436240606 0.0956504690311516 470 304.909090909091 315 0.00198694635764975 21 1.18796594445125 1.38709837938447 1 4.67653895782719 467 315 491 501 203 21 344 385 228 291 108 344 M17465 GO_APICOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICOLATERAL_PLASMA_MEMBRANE.html The apical end of the lateral plasma membrane of epithelial cells. 15/27 Gene Ontology CC GO:0016327 0.33572639478849 0.520876120974632 315 294.727272727273 315 0.0365044194707446 45 1.5186173000057 1.5186173000057 1 1.66132710920519 315 128 106 45 354 547 544 367 207 187 442 345 M17269 GO_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME.html A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. 313/765 Gene Ontology CC GO:0000228 0.757632743983792 0.90664953627874 145 319 316 0.120890271743879 144 1.25919261433189 -1.2451718004747 -1 0.206972429807678 144 508 207 535 328 235 360 244 396 316 236 346 M17683 GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. 24/80 Gene Ontology CC GO:0031463 0.143183655831926 0.302044354273186 335 345.727272727273 316 0.0139501175387192 120 0.525602276263726 -0.525602276263726 -1 1.0553938423618 496 245 279 270 120 335 316 560 311 539 332 347 M17246 GO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME.html A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. 269/639 Gene Ontology CC GO:0005813 0.121617940648672 0.266995767801073 175 308.090909090909 317 0.011719299789576 74 1.01152678610981 -0.651105250336468 -1 2.24037409043938 175 464 365 530 538 74 194 291 351 317 90 348 M17494 GO_DENDRITE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MEMBRANE.html The portion of the plasma membrane surrounding a dendrite. 12/37 Gene Ontology CC GO:0032590 0.542863974166669 0.733120039879287 455 356.363636363636 317 0.0686883391070909 132 1.01405746558881 -1.01405746558881 -1 0.528014373264098 451 234 132 208 299 432 550 573 317 166 558 349 M17429 GO_NUCLEOPLASM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPLASM_PART.html Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. 414/883 Gene Ontology CC GO:0044451 0.224142957941356 0.408689683564996 270 336.818181818182 318 0.0228074324072389 104 1.17313602703932 1.45053231939879 1 1.76064291360428 268 556 420 562 380 104 292 347 308 318 150 350 M17499 GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 71/125 Gene Ontology CC GO:0000779 0.326390120374029 0.515446692831116 60 331.909090909091 318 0.0352811420702577 57 0.674350887224881 -0.674350887224881 -1 0.749573589868658 57 347 271 430 450 250 314 318 468 480 266 351 M17062 GO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CENTROMERIC_REGION.html The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 112/318 Gene Ontology CC GO:0000775 0.336136320282937 0.520876120974632 270 349.818181818182 319 0.0365584870375856 58 0.854160742074571 -0.854160742074571 -1 0.934429228840804 58 510 267 552 462 247 368 319 489 309 267 352 M17132 GO_MITOTIC_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE.html A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. 33/75 Gene Ontology CC GO:0072686 0.763863666357023 0.910336493101771 285 319.272727272727 319 0.122969288765167 150 0.828434165228089 -0.592680838380628 -1 0.130530020054903 285 349 150 319 377 240 387 381 484 255 285 353 M17146 GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX.html A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. 7/13 Gene Ontology CC GO:0043240 0.413930187479028 0.605961617453683 390 334.818181818182 319 0.0520292543768905 130 0.399234478532755 -0.394524674269201 -1 0.335436190835366 390 130 456 255 217 299 311 525 319 386 395 354 M17147 GO_SEX_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_CHROMOSOME.html A chromosome involved in sex determination. 20/46 Gene Ontology CC GO:0000803 0.830197605310027 0.952091698153166 210 314.090909090909 319 0.148871972715684 175 1.33403223803043 -1.33403223803043 -1 0.10984781813288 208 427 175 374 319 258 379 398 460 219 238 355 M17270 GO_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an endocytic vesicle. 102/230 Gene Ontology CC GO:0030666 0.197666326574206 0.374593891016035 350 314.545454545455 320 0.0198218844506953 63 1.26319220527445 1.3834050869124 1 2.08036584414339 346 420 95 234 287 534 320 392 224 63 545 356 M17721 GO_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE.html The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. 180/399 Gene Ontology CC GO:0005819 0.110884743152214 0.249382807556342 320 305.090909090909 320 0.0106275249095274 100 1.07531894107921 -0.68247601930929 -1 2.50474654530273 320 452 165 386 100 175 402 409 414 272 261 357 M17145 GO_SPINDLE_POLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_POLE.html Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. 77/171 Gene Ontology CC GO:0000922 0.651421647306505 0.83034037853118 325 325.636363636364 321 0.0913618928008578 209 1.57972256568016 1.57972256568016 1 0.492610059538421 321 402 235 410 343 209 429 295 417 271 250 358 M17155 GO_TRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX.html A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). 385/832 Gene Ontology CC GO:1990234 0.0805825565807855 0.198790375109977 325 310.090909090909 321 0.00760863604093837 54 0.978947591711332 -0.893762617148336 -1 2.6525583465702 297 519 412 555 237 54 321 271 329 324 92 359 M17130 GO_CHROMOSOMAL_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOMAL_REGION.html Any subdivision of a chromosome along its length. 208/530 Gene Ontology CC GO:0098687 0.308132229020999 0.493049222615674 55 336.636363636364 323 0.0329328179967711 55 0.854160742074571 -0.854160742074571 -1 1.01308577254037 55 509 291 564 378 260 361 253 445 323 264 360 M17686 GO_RUFFLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE.html Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. 112/276 Gene Ontology CC GO:0001726 0.0240459632285584 0.107267931053281 325 317.181818181818 323 0.00221026168913842 54 1.21958809701457 1.36459214978371 1 4.56654265681068 576 324 54 173 128 323 567 528 230 168 418 361 M17750 GO_MICROTUBULE_ORGANIZING_CENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER.html An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. 354/819 Gene Ontology CC GO:0005815 0.055150851798388 0.176117084748444 215 310.181818181818 323 0.00514399644541211 42 1.06363071217033 -0.728725411818008 -1 3.09805830523444 211 451 353 524 575 42 206 323 341 310 76 362 M17296 GO_COSTAMERE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COSTAMERE.html Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. 11/29 Gene Ontology CC GO:0043034 0.0839184282471183 0.198790375109977 370 319.636363636364 324 0.00793650793650794 27 1.70956702222945 1.70956702222945 1 4.63224621674944 367 320 188 192 324 480 572 465 27 159 422 363 M17186 GO_BASAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 22/58 Gene Ontology CC GO:0009925 0.387086891060502 0.574203784463481 85 287.636363636364 326 0.0435271911013067 84 1.29994081892301 1.29994081892301 1 1.20958008061054 84 351 110 348 499 361 154 326 443 230 258 364 M17762 GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 78/190 Gene Ontology CC GO:0019897 0.475580891228103 0.66397525393682 440 331.545454545455 326 0.0569901523380595 123 1.30683019095237 1.30683019095237 1 0.897597117082083 437 317 123 421 474 208 326 412 373 274 282 365 M17803 GO_FILAMENTOUS_ACTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMENTOUS_ACTIN.html A two-stranded helical polymer of the protein actin. 19/46 Gene Ontology CC GO:0031941 0.0272417285853206 0.118388865581318 280 297.454545454545 326 0.00250772892918562 55 1.22333324258669 1.22333324258669 1 4.37816271463546 276 340 55 225 326 557 406 415 215 89 368 366 M17087 GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX.html The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. 8/15 Gene Ontology CC GO:0008540 0.467023231926383 0.653606363325543 500 344.454545454545 327 0.0609886798296039 158 0.240602732165967 -0.295770204167795 -1 0.171609853516708 260 496 447 475 496 255 263 158 327 370 242 367 M17090 GO_MHC_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. 19/50 Gene Ontology CC GO:0042611 0.807104936728249 0.938645177925409 370 330.454545454545 328 0.138948372223942 160 1.70932184675759 1.70932184675759 1 0.181529251591149 325 428 160 328 305 370 438 312 394 208 367 368 M17205 GO_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_COMPLEX.html An ion channel complex through which sodium ions pass. 3/17 Gene Ontology CC GO:0034706 0.0765897756730953 0.198790375109977 15 276.545454545455 328 0.00793650793650794 1 1.20418076991769 -1.20418076991769 -1 3.26285061670712 372 13 465 15 550 519 328 401 1 70 308 369 M17029 GO_KINESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_COMPLEX.html Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. 23/57 Gene Ontology CC GO:0005871 0.743247530067854 0.902514857939537 290 362.181818181818 329 0.116270175842122 146 0.862559895960135 -0.862559895960135 -1 0.148390976253131 230 563 146 505 514 287 329 289 508 351 262 370 M17663 GO_INTERCELLULAR_BRIDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCELLULAR_BRIDGE.html A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. 31/52 Gene Ontology CC GO:0045171 0.00736288425811293 0.0513186386674837 245 298.727272727273 329 0.000671603835107364 9 0.273513071701133 -0.247707512877977 -1 1.36234846866715 241 390 329 462 408 65 281 119 447 535 9 371 M16989 GO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME.html A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. 509/1183 Gene Ontology CC GO:0005694 0.518556661820479 0.705237060075852 100 337.909090909091 330 0.070489033153205 96 1.08637630262698 -0.938985146397018 -1 0.636324045718644 96 540 431 567 339 215 309 248 415 330 227 372 M17786 GO_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME.html A vacuole to which materials ingested by endocytosis are delivered. 468/1101 Gene Ontology CC GO:0005768 0.514011397665828 0.702360727779784 260 326.636363636364 330 0.0634920634920635 108 1.29928787339118 1.45968798497777 1 0.769939136923042 435 306 161 330 259 336 484 429 257 108 488 373 M17288 GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex that possesses activity that prevents or downregulates transcription. 35/99 Gene Ontology CC GO:0017053 0.0199253176270787 0.0959736132370957 335 335.090909090909 334 0.00182800930821074 28 1.70820157422404 1.70820157422404 1 6.71483210744234 533 426 331 455 28 459 334 228 146 263 483 374 M17060 GO_EXCITATORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. 106/315 Gene Ontology CC GO:0060076 0.466738071388703 0.653606363325543 335 362.545454545455 335 0.0555555555555556 159 1.2303823769986 1.366179750125 1 0.877570023262763 335 307 159 311 430 486 464 484 240 223 549 375 M17782 GO_PHOTORECEPTOR_DISC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_DISC_MEMBRANE.html Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment. 9/33 Gene Ontology CC GO:0097381 0.839060795636933 0.959286290336571 260 366.090909090909 335 0.166959367752229 183 0.448407011953656 0.617125436621815 1 0.0312611511159569 257 183 571 241 541 476 193 272 398 560 335 376 M17475 GO_CYTOPLASMIC_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_DYNEIN_COMPLEX.html Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. 8/29 Gene Ontology CC GO:0005868 0.0332306131568671 0.134316744088595 445 330.090909090909 336 0.00337382532474221 45 0.554099100968402 -0.554099100968402 -1 1.86574440708356 439 322 515 288 45 171 443 444 336 471 157 377 M17399 GO_NUCLEAR_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_HETEROCHROMATIN.html A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. 25/40 Gene Ontology CC GO:0005720 0.617782847125666 0.797811282479691 215 317.181818181818 337 0.0837200202488088 174 1.33403223803043 -1.33403223803043 -1 0.50541439315359 213 466 174 385 337 264 371 456 387 237 199 378 M17080 GO_CYTOPLASMIC_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SIDE_OF_MEMBRANE.html The side of a membrane that faces the cytoplasm. 89/232 Gene Ontology CC GO:0098562 0.180891357535668 0.355629947808218 340 318.909090909091 338 0.0179763312330129 89 1.49214751893561 1.49214751893561 1 2.58745477541904 304 256 89 345 338 434 339 434 320 242 407 379 M17018 GO_TRANSCRIPTION_EXPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_EXPORT_COMPLEX.html The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. 14/40 Gene Ontology CC GO:0000346 0.128575740747759 0.278339993079419 340 348.272727272727 339 0.012433540989814 113 0.185720909673488 -0.174902778315519 -1 0.398381156826101 339 444 332 507 113 159 303 524 545 348 217 380 M17413 GO_SIN3_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_TYPE_COMPLEX.html Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. 9/22 Gene Ontology CC GO:0070822 0.0146490166105093 0.0840686565746964 565 300.272727272727 339 0.00147464893173191 13 1.70820157422404 1.70820157422404 1 7.09428158953473 565 196 500 182 442 339 556 21 13 138 351 381 M17219 GO_SNARE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_COMPLEX.html A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. 28/55 Gene Ontology CC GO:0031201 0.340862666447532 0.525382989884463 290 295 340 0.0371840756370843 141 0.255658843588633 -0.284248635556126 -1 0.275989747365964 290 373 356 370 199 141 150 340 407 404 215 382 M17249 GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX.html A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. 4/11 Gene Ontology CC GO:0000164 0.293030606561338 0.481169575546743 385 343.909090909091 341 0.0340824404357146 155 0.303080420623556 -0.219167647351184 -1 0.371869580105818 384 155 476 230 192 565 313 341 249 416 462 383 M17629 GO_NEURON_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a neuron projection. 18/74 Gene Ontology CC GO:0032589 0.331647795137787 0.520146213026006 500 332.636363636364 341 0.0359681141665347 90 0.973004257090389 -0.973004257090389 -1 1.0667293837216 392 271 105 90 503 498 341 500 196 206 557 384 M17031 GO_HOLO_TFIIH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOLO_TFIIH_COMPLEX.html A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. 7/12 Gene Ontology CC GO:0005675 0.169686261627649 0.337831567055256 405 331.909090909091 342 0.0184233417504854 142 0.184210664093644 -0.232496822257229 -1 0.33529342571452 403 305 437 264 142 272 251 519 364 352 342 385 M17437 GO_CONNEXON_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNEXON_COMPLEX.html An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. 9/20 Gene Ontology CC GO:0005922 0.793496057563372 0.93063968500857 345 361.363636363636 342 0.145931243667191 150 0.505950515893818 0.487360651501784 1 0.0610003228826779 150 345 505 342 492 322 287 279 471 455 327 386 M17472 GO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE.html A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 82/151 Gene Ontology CC GO:0000776 0.179457223407254 0.3540145908853 45 345 342 0.0178201488117326 42 0.614224994096642 -0.614224994096642 -1 1.06978546550374 42 421 278 480 447 236 342 338 491 469 251 387 M17527 GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX.html A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. 10/26 Gene Ontology CC GO:0034663 0.493701792750794 0.685960663966248 565 314.727272727273 342 0.06 39 0.430132610782355 -0.386030471104055 -1 0.271935670034083 564 110 162 39 342 182 451 234 386 490 502 388 M17538 GO_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN.html A compact and highly condensed form of chromatin. 42/86 Gene Ontology CC GO:0000792 0.766005656612041 0.911010842637365 205 344.090909090909 342 0.123695518697784 169 1.00733861646773 -1.00733861646773 -1 0.157467515098431 203 514 169 488 356 251 480 342 482 277 223 389 M17414 GO_POSTSYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE.html A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. 73/268 Gene Ontology CC GO:0045211 0.751985672431077 0.903424291007479 335 368.636363636364 343 0.119047619047619 186 1.23484174155723 1.1091593505072 1 0.210350733553997 218 441 186 478 334 548 333 458 343 266 450 390 M17323 GO_MICROVILLUS_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_MEMBRANE.html The portion of the plasma membrane surrounding a microvillus. 13/30 Gene Ontology CC GO:0031528 0.26543333126279 0.454832862396741 475 326.636363636364 344 0.0276535793580326 74 1.12024665439912 -1.26395308557773 -1 1.48026992540104 474 228 100 74 258 515 540 498 392 170 344 391 M17529 GO_SEMAPHORIN_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_COMPLEX.html A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. 3/11 Gene Ontology CC GO:0002116 0.949731276771705 0.999999966915186 345 376.090909090909 344 0.258468190883929 226 0.397258199919961 0.397258199919961 1 1.62070700339931e-08 226 338 530 322 400 343 288 344 506 492 348 392 M17638 GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. 12/29 Gene Ontology CC GO:0080008 0.415388403648785 0.605961617453683 155 311.272727272727 344 0.047629072176856 110 0.212104975718254 -0.256325855004936 -1 0.178210269517038 154 469 367 415 493 170 110 224 344 529 149 393 M17419 GO_CATION_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_COMPLEX.html An ion channel complex through which cations pass. 62/225 Gene Ontology CC GO:0034703 0.35943518917414 0.545284880164444 350 365.818181818182 347 0.0396825396825397 122 1.11236287353897 -1.31348685373677 -1 1.13145328014127 347 532 122 420 315 571 243 576 202 176 520 394 M17050 GO_SAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_COMPLEX.html A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. 3/9 Gene Ontology CC GO:0000124 0.566898787863124 0.74981121140706 440 301.363636363636 349 0.0802729918113925 136 0.296736007272296 0.291701743010561 1 0.143304646535281 349 191 440 245 386 439 136 176 362 356 235 395 M17197 GO_TRANS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. 116/247 Gene Ontology CC GO:0005802 0.190444223482604 0.368149702919549 350 362.181818181818 349 0.019023061453564 147 1.24854072295383 1.42409753384759 1 2.09257492138394 500 346 255 365 147 348 569 494 376 235 349 396 M16987 GO_90S_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_90S_PRERIBOSOME.html A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 15/28 Gene Ontology CC GO:0030686 0.669411927964565 0.835680549381249 565 377.272727272727 352 0.0957285184101625 208 0.127740772409434 -0.182145776497902 -1 0.0384603039445052 250 568 380 565 478 217 234 352 564 334 208 397 M17259 GO_PML_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PML_BODY.html A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. 58/135 Gene Ontology CC GO:0016605 0.415320710913563 0.605961617453683 390 332.181818181818 352 0.0476190476190476 192 1.63188188878869 1.63188188878869 1 1.37110465477746 386 352 219 371 364 516 283 192 226 241 504 398 M17116 GO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE.html A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. 682/1632 Gene Ontology CC GO:0005773 0.00736928548339299 0.0513186386674837 420 275.090909090909 353 0.000739383801888566 13 1.33768215396201 1.52051245238028 1 6.66289632481176 420 111 453 149 103 364 478 353 68 13 514 399 M17284 GO_ACTOMYOSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN.html Any complex of actin, myosin, and accessory proteins. 47/116 Gene Ontology CC GO:0042641 0.196215690789239 0.374299238535247 355 355.363636363636 353 0.0196609092288914 94 1.2335167790473 1.2335167790473 1 2.03312107262221 353 453 94 303 228 444 511 490 288 284 461 400 M17208 GO_M_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_M_BAND.html The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. 9/40 Gene Ontology CC GO:0031430 0.205259024017714 0.382708760910448 355 306.454545454545 354 0.0227120126454822 103 0.436333455985511 -0.303719920346787 -1 0.702917967718013 354 224 468 280 434 103 117 420 412 400 159 401 M17401 GO_TCTN_B9D_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TCTN_B9D_COMPLEX.html A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins. 7/12 Gene Ontology CC GO:0036038 0.693981911410423 0.855269818326704 360 331.818181818182 354 0.11166922108646 137 0.332106585964178 -0.327501406719891 -1 0.0870843581592707 358 137 497 236 291 378 204 327 424 444 354 402 M17453 GO_PRESYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_MEMBRANE.html A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. 23/95 Gene Ontology CC GO:0042734 0.298735036746822 0.485024863032761 475 347.727272727273 356 0.0317460317460317 184 1.51935086267539 -1.51935086267539 -1 1.84385624431053 472 391 230 356 456 406 551 268 184 232 279 403 M17075 GO_ACROSOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_MEMBRANE.html The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. 7/29 Gene Ontology CC GO:0002080 0.015943519768694 0.0840686565746964 370 284.454545454545 357 0.00160590764494726 23 0.596908685700726 -0.488199490757262 -1 2.47900385821657 473 103 445 30 23 368 300 574 90 366 357 404 M17505 GO_SECRETORY_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_MEMBRANE.html The lipid bilayer surrounding a secretory granule. 44/123 Gene Ontology CC GO:0030667 0.416205470811613 0.605961617453683 310 329.363636363636 357 0.0477501542459389 113 0.361572382503678 0.382460137525488 1 0.303792555503204 201 357 113 310 309 389 209 383 449 484 419 405 M17104 GO_INO80_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INO80_TYPE_COMPLEX.html A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. 17/26 Gene Ontology CC GO:0097346 0.729356089533563 0.887511199474525 360 380.636363636364 359 0.112026834128286 228 0.202858055963793 -0.221033540743592 -1 0.0406026386491879 359 484 339 509 452 228 325 269 566 373 283 406 M17355 GO_CORTICAL_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_ACTIN_CYTOSKELETON.html The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. 43/106 Gene Ontology CC GO:0030864 0.421231067492462 0.611737580428751 495 335.363636363636 359 0.0484983086341954 77 1.13064183998703 1.0938723750217 1 0.931973166468947 491 309 115 77 413 346 427 481 359 196 475 407 M17671 GO_KERATIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATIN_FILAMENT.html A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. 20/107 Gene Ontology CC GO:0045095 0.395779508279962 0.585065360066031 155 327.636363636364 359 0.0447684080059472 112 0.377512850915782 -0.428827291478484 -1 0.339406046073295 165 491 153 515 513 154 112 359 461 536 145 408 M17457 GO_XY_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XY_BODY.html A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. 11/32 Gene Ontology CC GO:0001741 0.793780907801428 0.93063968500857 390 356.363636363636 360 0.133704096018741 217 0.374575931070611 -0.331203205836056 -1 0.0451610409609724 387 229 217 286 302 360 467 451 434 461 326 409 M17036 GO_NUCLEAR_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE.html The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. 9/30 Gene Ontology CC GO:0005640 0.661599658308824 0.835015289584759 355 374.181818181818 361 0.102688819100686 201 0.25481110341565 -0.29988116433379 -1 0.0770591174701811 361 367 438 411 536 355 273 201 466 353 355 410 M17717 GO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOST.html Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. 7/20 Gene Ontology CC GO:0018995 0.240412770070324 0.422366507904702 370 345.181818181818 361 0.0271233825678736 114 1.57416553838995 1.57416553838995 1 2.27559771106051 369 479 561 307 171 567 221 258 389 114 361 411 M17583 GO_ORGANELLE_ENVELOPE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ENVELOPE_LUMEN.html The region between the inner and outer lipid bilayers of an organelle envelope. 61/115 Gene Ontology CC GO:0031970 0.195785881064202 0.374299238535247 575 362.636363636364 362 0.0196132645052392 149 0.920158327725811 -0.805007704902447 -1 1.51663383603413 573 160 362 214 149 471 497 571 238 297 457 412 M17069 GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX.html A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. 10/16 Gene Ontology CC GO:0005671 0.921309192177062 0.999999966915186 260 372.909090909091 363 0.206349206349206 259 0.245929113232854 0.248086855723682 1 7.80959983208762e-09 259 321 337 392 558 428 304 335 405 363 400 413 M17070 GO_SARCOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the sarcoplasmic reticulum. 17/45 Gene Ontology CC GO:0033017 0.796944161638877 0.932456934063302 490 367.727272727273 364 0.134920634920635 163 0.429502738016081 -0.500257976893721 -1 0.0503780241982352 486 333 163 312 551 469 372 245 349 364 401 414 M17551 GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX.html RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 6/15 Gene Ontology CC GO:0005736 0.633495746396553 0.812403430733842 340 394.727272727273 364 0.095501393855385 143 0.111895964651372 0.125187188313932 1 0.0389915004136072 237 539 534 484 313 337 143 364 550 503 338 415 M17297 GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX.html A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. 41/83 Gene Ontology CC GO:0070603 0.387438539689892 0.574203784463481 380 333.545454545455 365 0.0435770914117222 149 1.73041933125535 1.73041933125535 1 1.61013542019309 443 365 328 383 431 149 376 270 379 275 270 416 M17622 GO_ENDOSOMAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOMAL_PART.html Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. 283/614 Gene Ontology CC GO:0044440 0.557443745451391 0.744116593235345 495 366.636363636364 365 0.0714285714285714 182 1.26629169895892 1.44699322955746 1 0.627730405651505 495 380 252 400 348 257 576 503 275 182 365 417 M17212 GO_CORTICAL_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON.html The portion of the cytoskeleton that lies just beneath the plasma membrane. 51/134 Gene Ontology CC GO:0030863 0.427843219486202 0.61978290943114 410 318 366 0.0494917000043012 91 1.13064183998703 1.0938723750217 1 0.907195480054665 408 327 117 91 383 279 366 515 372 227 413 418 M17443 GO_NUCLEAR_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. 29/73 Gene Ontology CC GO:0005637 0.340550332199709 0.525382989884463 315 364.909090909091 366 0.0371426088150514 173 0.960186285948682 0.960186285948682 1 1.03654374273171 313 455 315 458 198 423 173 495 360 458 366 419 M17744 GO_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_COMPLEX.html An ion channel complex through which calcium ions pass. 29/87 Gene Ontology CC GO:0034704 0.451983731374934 0.641883530060717 370 354.181818181818 366 0.0532093724505288 136 0.911238893341162 0.911238893341162 1 0.677602121979641 287 526 136 441 220 544 203 553 366 250 370 420 M17828 GO_MHC_CLASS_I_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_COMPLEX.html A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. 15/39 Gene Ontology CC GO:0042612 0.839790420260043 0.959286290336571 280 389 366 0.153359669144257 243 0.24726751587638 -0.246706401340065 -1 0.017238503858529 279 468 243 447 312 351 395 366 516 574 328 421 M17568 GO_PRESYNAPTIC_ACTIVE_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_ACTIVE_ZONE.html A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. 9/44 Gene Ontology CC GO:0048786 0.239631072597294 0.422320773784884 540 359 367 0.0270233093691024 132 1.3261771808088 -1.3261771808088 -1 1.91734912438937 539 336 537 367 169 426 574 132 252 139 478 422 M17206 GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX.html A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. 8/18 Gene Ontology CC GO:0005852 0.108732017244319 0.247429551052033 230 311.454545454545 368 0.0114450148127923 63 0.23332106235337 0.301193283087045 1 0.54655323977666 229 368 466 449 494 222 77 147 513 398 63 423 M17513 GO_TRANSPORTER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_COMPLEX.html A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. 102/394 Gene Ontology CC GO:1990351 0.0839184282471183 0.198790375109977 370 331.636363636364 368 0.00793650793650794 81 1.34203442973723 1.49403164733165 1 3.63637916906307 368 388 108 333 469 452 290 472 81 143 544 424 M17089 GO_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME.html An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. 141/339 Gene Ontology CC GO:0005840 0.676334925803979 0.840691585192903 305 395.363636363636 371 0.0974666514296043 275 0.657812056363 -0.564322045552235 -1 0.19145855102533 303 529 425 553 275 301 536 298 453 371 305 425 M17461 GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the inner mitochondrial membrane. 63/124 Gene Ontology CC GO:0098800 0.205959925745211 0.382780826626147 45 318.090909090909 371 0.020747327254267 45 0.564322045552235 -0.564322045552235 -1 0.908924905072969 45 446 415 500 272 152 169 371 483 464 182 426 M17649 GO_CHROMATOID_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATOID_BODY.html A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). 5/15 Gene Ontology CC GO:0033391 0.927459660523648 0.999999966915186 535 398.090909090909 373 0.230766909274417 275 0.166959380735889 0.19234894787799 1 3.42745499785065e-09 326 355 548 373 357 395 275 293 535 532 390 427 M17706 GO_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE.html Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. 35/99 Gene Ontology CC GO:0005643 0.941901217286798 0.999999966915186 275 400.636363636364 373 0.227939118268509 273 0.256513317460874 -0.259731805645097 -1 8.39693265462328e-09 273 383 344 526 373 318 446 370 499 545 330 428 M17111 GO_CD40_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD40_RECEPTOR_COMPLEX.html A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. 9/16 Gene Ontology CC GO:0035631 0.0677266553614883 0.196713602004725 240 348.636363636364 376 0.00698838875220695 33 0.26614116504597 -0.0974096997580672 -1 0.725824562409821 240 515 450 473 438 369 33 243 423 376 275 429 M17178 GO_PRECATALYTIC_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRECATALYTIC_SPLICEOSOME.html A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. 13/27 Gene Ontology CC GO:0071011 0.956545695312163 0.999999966915186 240 393.181818181818 377 0.248057208247783 239 0.155855778422971 -0.192683088197452 -1 2.81130002329949e-09 239 447 377 487 372 333 364 443 558 392 313 430 M17358 GO_SPECIFIC_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFIC_GRANULE.html Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. 11/29 Gene Ontology CC GO:0042581 0.286825684252022 0.472322636745494 180 347.909090909091 378 0.0302625808422815 179 0.219776224415199 0.235147086941906 1 0.276498739418116 264 429 318 378 179 418 418 179 486 434 324 431 M17477 GO_ENDOLYSOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME_MEMBRANE.html The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. 19/50 Gene Ontology CC GO:0036020 0.466738071388703 0.653606363325543 555 377.818181818182 378 0.0555555555555556 210 1.29644110978073 1.29644110978073 1 0.924686403612219 555 405 297 314 468 375 501 378 241 210 412 432 M17120 GO_NUCLEAR_SPECK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_SPECK.html A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. 122/306 Gene Ontology CC GO:0016607 0.020109729001872 0.0960613501081159 220 332.363636363636 379 0.00184508500270022 17 0.665455983212677 -0.665455983212677 -1 2.6148454052197 219 548 406 569 417 25 233 333 510 379 17 433 M17134 GO_NUCLEAR_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INCLUSION_BODY.html An intranuclear focus at which aggregated proteins have been sequestered. 9/14 Gene Ontology CC GO:0042405 0.0431264834014397 0.14837563932162 390 304.818181818182 379 0.00439870352292493 54 0.270743388498421 -0.258134071279435 -1 0.866433895522625 389 254 454 398 54 179 107 379 465 382 292 434 M17497 GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX.html A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. 11/24 Gene Ontology CC GO:0046540 0.977523831051926 0.999999966915186 305 397.727272727273 379 0.291798941342675 302 0.144904794733864 -0.148744809676913 -1 2.20361407723306e-09 302 379 390 413 535 354 306 372 517 478 329 435 M17739 GO_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX.html A macromolecular complex containing both protein and RNA molecules. 426/991 Gene Ontology CC GO:1990904 0.70356581575114 0.862845797555204 165 362.818181818182 379 0.104648675535719 162 0.900181915080944 -0.695352446282577 -1 0.22272882802545 162 578 427 570 379 224 419 261 410 322 239 436 M17780 GO_PROTEASOME_ACCESSORY_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ACCESSORY_COMPLEX.html A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. 17/28 Gene Ontology CC GO:0022624 0.916532927956332 0.999999966915186 560 410.363636363636 379 0.202086293580446 302 0.20039614371443 -0.223950232438736 -1 5.28290940458363e-09 341 565 379 557 347 319 385 302 442 558 319 437 M17468 GO_FILOPODIUM_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_TIP.html The end of a filopodium distal to the body of the cell. 20/35 Gene Ontology CC GO:0032433 0.232850105696956 0.415393089792717 540 344.272727272727 381 0.0238095238095238 142 1.31394404283802 1.31394404283802 1 1.93611355445742 538 277 204 190 381 427 470 413 142 221 524 438 M16990 GO_CONDENSED_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. 55/221 Gene Ontology CC GO:0000794 0.97376452614144 0.999999966915186 525 415.363636363636 382 0.281771509801527 212 0.852246096011289 0.852246096011289 1 4.14550073823132e-08 318 524 212 536 523 350 476 375 537 336 382 439 M17608 GO_PHAGOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a phagocytic vesicle. 55/111 Gene Ontology CC GO:0030670 0.504595642089355 0.699415542272536 235 385.454545454545 382 0.0618569300609813 231 0.988768470260939 1.12830806146295 1 0.592898620648845 505 481 231 324 232 382 571 550 338 234 392 440 M17241 GO_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of a ribosome. 52/104 Gene Ontology CC GO:0015935 0.514011397665828 0.702360727779784 385 387.363636363636 383 0.0634920634920635 242 0.751302067173766 0.751302067173766 1 0.445210698734289 463 382 416 360 242 340 568 431 264 412 383 441 M17515 GO_PHOTORECEPTOR_CONNECTING_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CONNECTING_CILIUM.html A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments. 22/62 Gene Ontology CC GO:0032391 0.682735079540934 0.845596464816449 385 363.272727272727 384 0.0991038471883921 146 0.240671958437144 0.293986994791166 1 0.0677001460961326 217 385 373 417 411 381 146 508 384 485 289 442 M17826 GO_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of acetyltransferase activity. 57/110 Gene Ontology CC GO:1902493 0.514011397665828 0.702360727779784 385 391.090909090909 385 0.0634920634920635 227 0.827888949868591 -0.84157669908996 -1 0.490594974241178 385 501 361 539 414 227 370 388 260 573 284 443 M17484 GO_CATALYTIC_STEP_2_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_STEP_2_SPLICEOSOME.html A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. 49/158 Gene Ontology CC GO:0071013 0.869188940151143 0.981999660419834 190 389.454545454545 386 0.16882025511079 187 0.498005606198256 -0.498005606198256 -1 0.0151722671962289 187 512 386 542 355 276 450 317 528 475 256 444 M17634 GO_IKAPPAB_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IKAPPAB_KINASE_COMPLEX.html A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 6/12 Gene Ontology CC GO:0008385 0.133653193925042 0.285061055677766 515 368.818181818182 386 0.0142445704181786 125 0.310198475259793 -0.221223643471289 -1 0.652978220647479 512 190 547 217 125 536 465 386 195 528 356 445 M16999 GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX.html A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. 14/29 Gene Ontology CC GO:0005669 0.859902713357216 0.976471057604069 430 389.909090909091 387 0.163621804466973 192 0.185257258889178 -0.18073855605834 -1 0.00739834722191843 430 504 303 551 472 278 192 387 567 340 265 446 M17248 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY.html A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. 42/84 Gene Ontology CC GO:0000932 0.66433121042909 0.835015289584759 525 401.363636363636 388 0.0944738497920141 192 1.4346766736595 1.4346766736595 1 0.433870124702617 524 550 376 519 271 259 502 522 312 192 388 447 M17718 GO_PIGMENT_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE.html A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. 70/141 Gene Ontology CC GO:0048770 0.618372758738584 0.797811282479691 225 313.272727272727 388 0.0838486724299807 137 1.20532921979341 1.20532921979341 1 0.456653683512402 221 433 246 418 415 393 137 196 388 193 406 448 M17221 GO_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIGASE_COMPLEX.html A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. 134/305 Gene Ontology CC GO:0000151 0.0157311940333903 0.0840686565746964 525 329.454545454545 389 0.00144043815714659 16 0.525602276263726 -0.525602276263726 -1 2.18286331149522 202 521 389 525 566 16 213 274 431 406 81 449 M17114 GO_CYTOSOLIC_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PART.html Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. 123/339 Gene Ontology CC GO:0044445 0.96855221189793 0.999999966915186 390 422.363636363636 390 0.26984126984127 311 1.53150662091758 1.53150662091758 1 7.91481577349955e-08 466 558 418 576 390 377 386 377 429 311 358 450 M17149 GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX.html A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. 10/15 Gene Ontology CC GO:0005847 0.232850105696956 0.415393089792717 355 343 391 0.0238095238095238 105 2.33610118343885 2.33610118343885 1 3.44227533619881 355 448 206 391 471 529 558 105 118 149 443 451 M17422 GO_MLL1_2_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MLL1_2_COMPLEX.html A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. 14/35 Gene Ontology CC GO:0044665 0.887585681790779 0.996164124417612 305 384.454545454545 391 0.18019406637058 251 0.217918119762548 -0.245453836078545 -1 0.00140471329723469 301 398 349 457 520 305 391 251 538 450 269 452 M17777 GO_EARLY_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME.html A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. 195/455 Gene Ontology CC GO:0005769 0.597318307603006 0.777590049086797 395 363.727272727273 391 0.0793650793650794 124 1.35864675513419 1.45469556577644 1 0.573242372569812 391 432 154 412 322 363 477 466 292 124 568 453 M17016 GO_FILOPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a filopodium. 11/22 Gene Ontology CC GO:0031527 0.698152987361708 0.858579631266101 455 381.545454545455 393 0.103174603174603 144 0.970454883618695 0.970454883618695 1 0.248183984092009 393 298 144 250 451 532 492 521 316 346 454 454 M17059 GO_LATE_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a late endosome. 72/129 Gene Ontology CC GO:0031902 0.557443745451391 0.744116593235345 445 368.818181818182 393 0.0714285714285714 189 1.83974608420251 1.83974608420251 1 0.912005156496838 456 445 312 445 426 189 532 393 280 264 315 455 M17064 GO_DNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_COMPLEX.html A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. 8/13 Gene Ontology CC GO:0042575 0.918986889777588 0.999999966915186 375 388.909090909091 394 0.222222222222222 237 0.839316232100865 -0.839316232100865 -1 4.07375105066003e-08 374 370 443 321 409 394 237 492 413 361 464 456 M17102 GO_NUCLEOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLAR_PART.html Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. 31/65 Gene Ontology CC GO:0044452 0.775485941583084 0.918505889825866 375 416 394 0.126984126984127 272 0.198369170520162 0.203149110073413 1 0.0282830304773203 300 561 394 531 374 512 272 408 346 372 506 457 M17703 GO_TELOMERE_CAP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAP_COMPLEX.html A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. 5/14 Gene Ontology CC GO:0000782 0.56841962030829 0.75010625693651 395 385.090909090909 394 0.0805964649005514 242 0.317382103227238 0.284180732339915 1 0.153065973684412 395 242 557 363 257 448 394 260 374 543 403 458 M17533 GO_MIDBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBODY.html A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. 90/198 Gene Ontology CC GO:0030496 0.667434366415499 0.835015289584759 245 371.272727272727 395 0.0952380952380952 145 1.33586475568885 1.79634839217452 1 0.403987754314956 407 499 145 395 367 435 241 468 313 244 570 459 M17716 GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE.html A clathrin coat found on an endocytic vesicle. 9/17 Gene Ontology CC GO:0030128 0.214139132665174 0.391900034560824 395 388.636363636364 395 0.0238095238095238 131 1.21455215107271 1.21455215107271 1 1.9082555079442 568 395 560 283 392 409 353 530 131 141 513 460 M16985 GO_PHAGOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. 84/188 Gene Ontology CC GO:0045335 0.850621352955467 0.967832956709173 450 404.909090909091 396 0.158730158730159 226 0.988768470260939 1.12830806146295 1 0.0542229968825641 450 470 226 396 534 325 521 541 371 281 339 461 M17578 GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). 22/36 Gene Ontology CC GO:0000315 0.943980227442223 0.999999966915186 210 381.909090909091 396 0.230492513878739 210 0.179097685058868 -0.189990354143784 -1 4.10102708557907e-09 210 467 396 477 433 321 274 294 497 514 318 462 M17732 GO_SPERM_FLAGELLUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_FLAGELLUM.html A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. 28/88 Gene Ontology CC GO:0036126 0.753374581774403 0.903424291007479 425 374.636363636364 396 0.119497259026491 223 0.317378035774474 -0.376252154723285 -1 0.0540641727897282 421 435 223 427 542 233 396 275 358 548 263 463 M17317 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX.html A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. 14/31 Gene Ontology CC GO:0097526 0.979786668101293 0.999999966915186 275 404.818181818182 397 0.298597866672955 275 0.138223643667209 -0.13999012969672 -1 1.83286732771577e-09 275 436 397 466 502 359 336 380 530 426 346 464 M17055 GO_ZYMOGEN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_GRANULE.html A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. 7/28 Gene Ontology CC GO:0042588 0.38476133513668 0.574203784463481 480 378.363636363636 399 0.0474136323090159 141 0.266569438579736 0.239252826313249 1 0.248039812489738 558 235 442 252 295 479 479 141 399 360 522 465 M17460 GO_COP9_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_COP9_SIGNALOSOME.html A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. 21/56 Gene Ontology CC GO:0008180 0.325396452010714 0.515446692831116 160 351.090909090909 399 0.0351518564953795 129 0.554099100968402 -0.554099100968402 -1 0.615907918892412 156 542 270 442 399 129 212 546 568 463 135 466 M17168 GO_LUMENAL_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUMENAL_SIDE_OF_MEMBRANE.html Any side (leaflet) of a membrane that faces the lumen of an organelle. 26/66 Gene Ontology CC GO:0098576 0.573455499003966 0.755027969075837 445 353.727272727273 401 0.0745341554412615 120 1.5046313328403 1.5046313328403 1 0.709144153216429 445 489 135 351 329 292 444 450 401 120 435 467 M17357 GO_GLIAL_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_PROJECTION.html A prolongation or process extending from a glial cell. 7/32 Gene Ontology CC GO:0097386 0.260512189608753 0.448142992838866 165 343.545454545455 401 0.0297288864722297 84 0.205649609889909 0.257380091273109 1 0.276851969384103 163 462 492 401 265 253 84 457 539 433 230 468 M17797 GO_U12_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U12_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. 14/35 Gene Ontology CC GO:0005689 0.958923694297575 0.999999966915186 405 444.181818181818 401 0.251894491663049 306 0.172111649536126 -0.195768930683453 -1 3.71336185600577e-09 401 544 343 534 397 353 482 306 571 562 393 469 M16997 GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the nucleus. 9/15 Gene Ontology CC GO:0000176 0.553554050666001 0.742353228039323 435 376 402 0.0774776668756807 223 0.281470553067585 -0.226791340554305 -1 0.140651604354821 431 223 432 272 251 397 435 518 402 339 436 470 M17061 GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 133/294 Gene Ontology CC GO:0061695 0.109927835636356 0.248196441397709 455 384.636363636364 402 0.0105307714111483 99 1.06915557256506 1.1266154076811 1 2.49894134642006 453 332 383 402 99 429 515 578 227 288 525 471 M17213 GO_MYOSIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_FILAMENT.html A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. 9/29 Gene Ontology CC GO:0032982 0.804956120936968 0.938033544156386 350 407.636363636364 402 0.150793650793651 226 0.468670611621498 -0.503964893967335 -1 0.050285000211072 350 546 470 496 521 310 226 421 363 402 379 472 M17748 GO_MITOCHONDRIAL_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PROTEIN_COMPLEX.html A protein complex that is part of a mitochondrion. 75/156 Gene Ontology CC GO:0098798 0.15873824669193 0.325357115560055 40 329.090909090909 403 0.015591038497106 38 0.629639554558714 -0.629639554558714 -1 1.18577993044036 38 408 414 495 403 151 163 343 478 552 175 473 M17124 GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription. 10/28 Gene Ontology CC GO:0090568 0.968727538692975 0.999999966915186 570 433.363636363636 404 0.270212280067644 341 0.217154322238734 -0.261149248537806 -1 6.21284500306526e-09 566 387 355 404 455 341 570 402 433 380 474 474 M17188 GO_NUCLEAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_BODY.html Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. 213/505 Gene Ontology CC GO:0016604 0.44763095361698 0.638841212816331 405 396.090909090909 404 0.0525281775009223 165 1.15525347417905 -0.678625059569405 -1 0.868258316405503 404 557 401 574 371 165 428 534 427 315 181 475 M17544 GO_SARCOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASM.html The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. 33/102 Gene Ontology CC GO:0016528 0.655886237852564 0.833191748305015 530 399.636363636364 404 0.0924260878049841 140 0.396489696028075 -0.353712700024681 -1 0.121358952860518 529 404 140 503 524 367 322 310 408 498 391 476 M17099 GO_RNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_COMPLEX.html Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. 63/133 Gene Ontology CC GO:0030880 0.193779132499262 0.373347795281911 310 368.636363636364 405 0.0193911208445252 148 1.07643464219997 1.07643464219997 1 1.77880853291332 411 465 405 493 148 309 408 308 432 300 376 477 M17038 GO_CATION_TRANSPORTING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_COMPLEX.html Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 9/21 Gene Ontology CC GO:0090533 0.435369722646862 0.624426053821057 450 325.454545454545 406 0.0555555555555556 61 1.38933387508025 1.38933387508025 1 1.09737054217187 447 61 439 82 406 574 453 222 233 136 527 478 M17047 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE.html The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 12/28 Gene Ontology CC GO:0031306 0.280503675821903 0.465510301364665 330 389 406 0.0294842267252854 176 0.242653033006503 -0.231074576526932 -1 0.311192646671199 537 406 330 423 176 451 323 330 480 354 469 479 M17458 GO_MITOCHONDRIAL_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_PART.html Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. 95/199 Gene Ontology CC GO:0044455 0.663837316127189 0.835015289584759 140 363.181818181818 406 0.0943528064014082 137 0.564322045552235 -0.564322045552235 -1 0.170660383409647 137 531 419 538 297 212 277 406 496 462 220 480 M17542 GO_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX.html Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. 104/251 Gene Ontology CC GO:0005681 0.763392867181015 0.910336493101771 240 393.636363636364 407 0.122810470029721 143 0.566951512700948 -0.566951512700948 -1 0.0893302013640013 143 549 407 561 479 239 393 314 512 496 237 481 M17215 GO_NEURONAL_POSTSYNAPTIC_DENSITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_POSTSYNAPTIC_DENSITY.html A postsynaptic density that is part of a neuron. 43/96 Gene Ontology CC GO:0097481 0.35943518917414 0.545284880164444 555 345.454545454545 408 0.0396825396825397 180 1.07790752191635 -1.04931921283007 -1 1.0964066045102 551 220 199 180 567 408 421 438 189 195 432 482 M17226 GO_U2_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U2. 9/24 Gene Ontology CC GO:0005686 0.931999858612868 0.999999966915186 475 411.272727272727 408 0.235722663241907 278 0.191399574026675 -0.176571932541714 -1 4.78367672218137e-09 426 278 472 335 362 404 439 473 522 408 405 483 M17473 GO_INTERSTITIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTITIAL_MATRIX.html A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. 7/18 Gene Ontology CC GO:0005614 0.692053852342561 0.854716082594018 340 395.636363636364 410 0.111111111111111 206 0.539421148889302 0.461813272154741 1 0.142031949191565 340 206 513 263 344 523 528 410 324 470 431 484 M17015 GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK.html A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. 10/15 Gene Ontology CC GO:0071782 0.751985672431077 0.903424291007479 355 426.454545454545 412 0.119047619047619 308 0.237669147297758 0.173812153569461 1 0.0404860574224938 540 412 351 308 475 559 499 351 334 345 517 485 M17565 GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. 54/135 Gene Ontology CC GO:0031234 0.531133297018154 0.718957952403964 485 377.181818181818 412 0.0665406734332523 131 1.46693471565438 1.46693471565438 1 0.811819424567103 481 179 131 331 412 416 487 516 365 289 542 486 M17247 GO_SET1C_COMPASS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SET1C_COMPASS_COMPLEX.html A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. 5/11 Gene Ontology CC GO:0048188 0.98692404258466 0.999999966915186 475 429.545454545455 415 0.35189204849947 362 0.125450365294747 -0.123080049736282 -1 1.12405961029941e-09 441 401 475 377 506 398 507 362 474 415 369 487 M17556 GO_SMN_SM_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_SM_PROTEIN_COMPLEX.html A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. 10/21 Gene Ontology CC GO:0034719 0.995177668372914 0.999999966915186 390 453.909090909091 415 0.384274689178381 357 0.114329671227371 -0.16419917307397 -1 5.0695618953807e-10 388 572 357 541 480 386 384 389 575 506 415 488 M17699 GO_NUCLEOLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLUS.html A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. 500/1232 Gene Ontology CC GO:0005730 0.816521443770307 0.946303972968662 445 420.090909090909 416 0.142857142857143 312 1.06305597376211 -0.864128578990533 -1 0.0984068131179957 442 577 421 568 333 316 546 416 361 329 312 489 M17604 GO_AXOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXOLEMMA.html The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. 6/34 Gene Ontology CC GO:0030673 0.562604368603265 0.747552471385488 285 402.454545454545 417 0.0793650793650794 159 0.931951048591966 -0.931951048591966 -1 0.454789030364205 417 284 543 159 304 550 358 448 283 520 561 490 M17022 GO_U1_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U1_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U1. 6/22 Gene Ontology CC GO:0005685 0.623554814106493 0.802705306355352 410 414.909090909091 418 0.0930775036721065 189 0.201564807862191 -0.126031984744472 -1 0.0742977641836804 410 497 436 459 418 535 365 189 495 349 411 491 M17617 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE.html The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 27/59 Gene Ontology CC GO:0098573 0.782920537038877 0.925295924487648 325 418.454545454545 418 0.129652647481505 174 0.199938451547446 -0.17273766226599 -1 0.0260368521933102 322 534 385 547 335 462 174 418 505 524 397 492 M17105 GO_CELL_CORTEX_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_PART.html Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 75/185 Gene Ontology CC GO:0044448 0.378980882860807 0.570183930226334 465 347.363636363636 419 0.042384072451237 33 0.9639994288178 1.02459167547471 1 0.908349530429737 464 250 109 33 453 433 564 419 306 213 577 493 M17217 GO_INTERMEDIATE_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT.html A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. 48/224 Gene Ontology CC GO:0005882 0.103185552803077 0.236671625080073 580 398.818181818182 419 0.00985172318914791 80 1.48994972410217 1.48994972410217 1 3.60128555737692 578 513 80 545 518 338 343 423 419 216 414 494 M17240 GO_POTASSIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_COMPLEX.html An ion channel complex through which potassium ions pass. 31/123 Gene Ontology CC GO:0034705 0.597318307603006 0.777590049086797 415 407.090909090909 419 0.0793650793650794 233 1.42279293755586 -1.42279293755586 -1 0.600307030869096 414 560 233 494 419 507 238 501 290 251 571 495 M17202 GO_ORGANELLE_MEMBRANE_CONTACT_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_CONTACT_SITE.html A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. 4/13 Gene Ontology CC GO:0044232 0.0765897756730953 0.198790375109977 465 328.181818181818 420 0.00793650793650794 29 0.552727095388635 -0.786962080104847 -1 1.49767043728828 504 39 464 171 130 463 554 439 29 397 420 496 M17592 GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX.html A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. 3/20 Gene Ontology CC GO:0005892 0.683206832299796 0.845596464816449 325 386.909090909091 420 0.108589838087308 149 0.365276731618558 0.398493195392234 1 0.1027510183739 323 149 540 211 522 493 505 204 420 518 371 497 M17757 GO_NBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NBAF_COMPLEX.html A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 8/16 Gene Ontology CC GO:0071565 0.752630181191376 0.903424291007479 295 389 421 0.130369684190502 176 0.243902576665162 -0.318170181828132 -1 0.0415478991405455 465 295 568 341 425 293 176 286 455 554 421 498 M17440 GO_SMOOTH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_ENDOPLASMIC_RETICULUM.html The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. 23/64 Gene Ontology CC GO:0005790 0.928672844283565 0.999999966915186 425 415.909090909091 423 0.213406332079908 223 0.288745997909424 0.241394082346759 1 1.01855707778011e-08 544 410 274 369 445 447 223 563 421 456 423 499 M17567 GO_POLYSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSOME.html A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. 15/60 Gene Ontology CC GO:0005844 0.828174617740166 0.95165989871534 540 425.363636363636 423 0.147955095596702 235 0.182692893025366 -0.190725763825514 -1 0.0151824232089799 423 536 382 540 404 366 461 235 490 509 333 500 M17292 GO_EXON_EXON_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXON_EXON_JUNCTION_COMPLEX.html A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. 15/51 Gene Ontology CC GO:0035145 0.818602052741057 0.946303972968662 570 439.636363636364 425 0.143745350861651 233 0.127488790123292 -0.161196064403158 -1 0.0118015987800324 415 570 359 573 477 311 378 526 569 425 233 501 M17470 GO_AXONEME_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_PART.html Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 7/32 Gene Ontology CC GO:0044447 0.303305997577459 0.489471906667304 250 361.545454545455 426 0.0354956133640243 123 0.29135051182822 -0.327505745697653 -1 0.349117590883292 247 528 512 426 457 269 285 123 437 468 225 502 M16978 GO_CLATHRIN_SCULPTED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_SCULPTED_VESICLE.html A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. 5/26 Gene Ontology CC GO:0060198 0.675111569135387 0.840691585192903 430 401.363636363636 428 0.106337725791995 199 0.245054799167242 -0.274942148555962 -1 0.0713240718334585 519 422 428 199 283 308 437 512 548 331 428 503 M17339 GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT.html The large subunit of a ribosome located in the cytosol. 34/129 Gene Ontology CC GO:0022625 0.159990863507958 0.326765791899646 195 394.909090909091 429 0.0157243796110003 53 0.131096181283874 0.133499910438423 1 0.245939270894722 194 502 413 522 511 289 53 565 557 429 309 504 M17483 GO_SPERM_PRINCIPAL_PIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PRINCIPAL_PIECE.html The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. 13/29 Gene Ontology CC GO:0097228 0.978161938897681 0.999999966915186 575 437.545454545455 429 0.293650793650794 215 0.325550093253081 -0.332084429714991 -1 1.22278833346426e-08 574 358 215 409 572 379 545 417 441 474 429 505 M17218 GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT.html The small subunit of a ribosome located in the cytosol. 33/76 Gene Ontology CC GO:0022627 0.751985672431077 0.903424291007479 550 445 432 0.119047619047619 342 0.16348462820651 -0.192806976436716 -1 0.0278489980187861 548 525 409 454 396 449 510 432 342 403 427 506 M17354 GO_NUCLEAR_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EUCHROMATIN.html The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. 20/47 Gene Ontology CC GO:0005719 0.602887203734507 0.783075963502349 545 394.545454545455 432 0.0805298692850143 240 0.28560466145412 -0.324383656936001 -1 0.117135061947763 542 443 240 439 256 380 246 510 492 432 360 507 M17479 GO_CHD_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHD_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. 7/23 Gene Ontology CC GO:0090545 0.918986889777588 0.999999966915186 435 406.272727272727 432 0.222222222222222 266 0.26866878651454 -0.297816168940483 -1 9.07145723811853e-09 545 266 516 287 486 327 432 292 411 473 434 508 M16980 GO_AGGRESOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGGRESOME.html An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. 20/47 Gene Ontology CC GO:0016235 0.435049058972292 0.624426053821057 490 406.818181818182 435 0.0505862405163264 145 0.290134844078052 -0.278212930443069 -1 0.229164083913285 517 490 268 435 424 489 448 145 426 332 501 509 M17066 GO_TELOMERASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_HOLOENZYME_COMPLEX.html Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. 9/23 Gene Ontology CC GO:0005697 0.97118236082518 0.999999966915186 445 428.727272727273 436 0.298599873412422 337 0.234922619349697 -0.220599981769317 -1 7.19883354495359e-09 476 431 444 436 420 437 404 337 524 362 445 510 M17380 GO_DNA_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR_COMPLEX.html A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 24/43 Gene Ontology CC GO:1990391 0.895922572032401 0.999999966915186 320 435.090909090909 436 0.185916828215241 276 0.161961563613924 -0.172209562994509 -1 3.15011888702713e-09 317 564 368 566 537 285 375 507 555 436 276 511 M17397 GO_CELL_DIVISION_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION_SITE.html The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. 31/80 Gene Ontology CC GO:0032153 0.970743594616198 0.999999966915186 570 399.545454545455 436 0.274620058241552 192 0.802185526135682 0.802185526135682 1 3.86770738533148e-08 570 287 192 267 473 344 456 502 436 443 425 512 M17383 GO_ESCRT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_COMPLEX.html An endosomal sorting complex required for transport. 20/28 Gene Ontology CC GO:0036452 0.891700527734629 0.998842839206619 425 438.363636363636 437 0.182968579992642 210 0.17169975744201 0.173164912195637 1 0.000333429900904451 422 566 302 559 340 545 210 349 553 437 539 513 M17433 GO_CELL_CELL_ADHERENS_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHERENS_JUNCTION.html An adherens junction which connects a cell to another cell. 33/93 Gene Ontology CC GO:0005913 0.878859116702268 0.989059643164186 385 420.454545454545 440 0.174603174603175 177 1.70956702222945 1.70956702222945 1 0.031542888936301 477 471 177 440 528 383 533 404 383 257 572 514 M17435 GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX.html A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. 5/10 Gene Ontology CC GO:0031414 0.995104888146613 0.999999966915186 440 434.272727272727 440 0.412542758050142 261 0.195480503741428 -0.194063552610782 -1 5.01013342277961e-09 440 261 503 334 437 413 485 556 479 453 416 515 M17209 GO_NPBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NPBAF_COMPLEX.html A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. 9/15 Gene Ontology CC GO:0071564 0.926884089680607 0.999999966915186 420 443.363636363636 441 0.23015873015873 289 0.230238770355512 0.151513342596086 1 6.938919980285e-09 543 289 469 346 501 420 498 441 416 401 553 516 M16986 GO_ENDOLYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME.html An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. 25/66 Gene Ontology CC GO:0036019 0.729352960357319 0.887511199474525 380 400 442 0.112025900795249 151 1.29644110978073 1.29644110978073 1 0.259486546116835 509 442 151 376 292 466 520 511 378 236 519 517 M17516 GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE.html The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. 6/14 Gene Ontology CC GO:0000940 0.997199246102742 0.999999966915186 490 437.909090909091 444 0.444444444444444 323 0.340589319716266 -0.347008455558817 -1 1.30624317935614e-08 357 323 524 375 488 440 462 430 488 486 444 518 M17402 GO_PRC1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRC1_COMPLEX.html A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. 9/12 Gene Ontology CC GO:0035102 0.00494317211319326 0.0386101821814285 35 281 445 0.000495420238884042 5 0.266389759756828 -0.297358872548964 -1 1.45399985129754 152 492 498 450 454 34 35 32 494 445 5 519 M17415 GO_SMALL_SUBUNIT_PROCESSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_SUBUNIT_PROCESSOME.html A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 16/36 Gene Ontology CC GO:0032040 0.868232566693822 0.981999660419834 410 462.272727272727 447 0.168269642246445 327 0.128295257094495 -0.147631801611011 -1 0.00390864628487371 406 567 384 575 327 411 493 513 563 447 399 520 M17590 GO_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SUBUNIT.html Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. 109/272 Gene Ontology CC GO:0044391 0.616016657937863 0.797811282479691 520 444.454545454545 449 0.0833359133710311 261 0.751302067173766 0.751302067173766 1 0.284639954064886 546 511 426 517 261 407 449 374 457 517 424 521 M17051 GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the cytoplasm. 8/16 Gene Ontology CC GO:0000153 0.995738886031923 0.999999966915186 555 435.090909090909 451 0.420634920634921 255 0.290035031799762 -0.241552093936313 -1 1.02571011353836e-08 553 255 441 339 491 467 410 545 477 357 451 522 M17430 GO_SYNAPTONEMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX.html A proteinaceous scaffold found between homologous chromosomes during meiosis. 21/151 Gene Ontology CC GO:0000795 0.664653804146475 0.835015289584759 535 420.090909090909 451 0.0945529983571073 213 0.264033150347884 -0.28269829126604 -1 0.0798480181192227 382 535 222 529 576 213 458 407 531 451 317 523 M17207 GO_CCR4_NOT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR4_NOT_COMPLEX.html The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins. 9/18 Gene Ontology CC GO:0030014 0.869868211306151 0.981999660419834 455 430.727272727273 452 0.184473007615577 268 0.178531768487544 -0.162635608699456 -1 0.00543915529445914 452 478 467 452 547 357 455 425 438 399 268 524 M17620 GO_INTERMEDIATE_FILAMENT_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_CYTOSKELETON.html Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. 85/303 Gene Ontology CC GO:0045111 0.921309192177062 0.999999966915186 435 431.181818181818 453 0.206349206349206 173 1.48994972410217 1.48994972410217 1 7.68421053406359e-08 432 522 173 546 428 453 512 482 404 282 509 525 M17441 GO_ENDORIBONUCLEASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_COMPLEX.html A protein complex which is capable of endoribonuclease activity. 11/22 Gene Ontology CC GO:1902555 0.985023615986936 0.999999966915186 560 441.545454545455 457 0.317460317460317 249 0.222154937978167 -0.20388526705613 -1 6.49033641322553e-09 560 249 363 306 483 496 519 442 450 457 532 526 M17555 GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX.html A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. 8/22 Gene Ontology CC GO:0005732 0.980877249843087 0.999999966915186 455 466 458 0.326783060620026 401 0.177499075637658 -0.169974412311108 -1 4.01231793340629e-09 458 407 535 428 401 455 488 453 526 505 470 527 M17071 GO_U2_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. 18/43 Gene Ontology CC GO:0005684 0.788365081210702 0.928055024317282 545 457 459 0.131660100612125 301 0.169239415882772 -0.139968792601741 -1 0.0211939297304302 459 543 364 550 301 504 430 400 544 365 567 528 M17452 GO_SPINDLE_MIDZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MIDZONE.html The area in the center of the spindle where the spindle microtubules from opposite poles overlap. 10/32 Gene Ontology CC GO:0051233 0.0793401169706105 0.198790375109977 300 393.818181818182 459 0.00748679706895836 34 0.237296648218487 -0.197840653123946 -1 0.642979466771498 296 485 202 461 571 392 34 564 554 459 314 529 M17258 GO_CYTOSOLIC_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PROTEASOME_COMPLEX.html A proteasome complex found in the cytosol of a cell. 7/14 Gene Ontology CC GO:0031597 0.991890500488496 0.999999966915186 435 460.363636363636 460 0.382126733243462 384 0.124814668684667 -0.170741379460765 -1 1.08878388467739e-09 434 507 478 460 553 384 466 435 511 419 417 530 M17455 GO_NUCLEAR_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE_PART.html Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. 7/16 Gene Ontology CC GO:0044453 0.239656079241249 0.422320773784884 520 406.909090909091 460 0.0270265092949399 170 0.960186285948682 0.960186285948682 1 1.38820993085945 518 363 506 347 170 478 522 178 368 460 566 531 M17276 GO_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME.html Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. 35/70 Gene Ontology CC GO:0030684 0.992739629671303 0.999999966915186 425 482.545454545455 461 0.360939894653556 399 0.13209664002748 -0.133361288244095 -1 1.49287102153326e-09 506 562 399 577 421 461 452 483 570 421 456 532 M16994 GO_RETROMER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROMER_COMPLEX.html A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. 15/25 Gene Ontology CC GO:0030904 0.370023895065814 0.558417262005328 520 404.909090909091 462 0.0411366167231231 102 0.664904966411386 -0.664904966411386 -1 0.649776198556728 516 476 245 387 316 569 102 462 518 337 526 533 M17220 GO_DNA_REPLICATION_FACTOR_A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_FACTOR_A_COMPLEX.html A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. 11/14 Gene Ontology CC GO:0005662 0.956570603741168 0.999999966915186 370 455.818181818182 463 0.248096402179273 368 0.189612394442936 -0.186094920709548 -1 4.68450353856909e-09 515 375 370 416 368 506 560 538 498 405 463 534 M17347 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. 8/16 Gene Ontology CC GO:0033178 0.965428386966392 0.999999966915186 550 446.818181818182 463 0.285714285714286 265 0.287760226164027 -0.2013014852416 -1 1.01308688758794e-08 547 265 489 384 463 503 377 555 435 430 467 535 M17231 GO_PRONUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRONUCLEUS.html The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. 9/23 Gene Ontology CC GO:0045120 0.274925759800308 0.460633830574186 415 420.272727272727 465 0.0316368653093842 186 0.268057308889885 -0.285588125292409 -1 0.348507228222349 479 414 474 465 186 465 258 529 540 411 402 536 M17469 GO_MISMATCH_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR_COMPLEX.html Any complex formed of proteins that act in mismatch repair. 6/12 Gene Ontology CC GO:0032300 0.666554070651892 0.835015289584759 470 429.181818181818 467 0.104011280352989 202 0.127269191154209 -0.146053555054825 -1 0.038488318112971 427 576 511 558 470 307 389 202 565 467 249 537 M17519 GO_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of a membrane. 502/1255 Gene Ontology CC GO:0098796 0.0153828764922276 0.0840686565746964 490 347.545454545455 469 0.00154904104298749 17 1.32044572326354 1.48987762618408 1 5.48390419703264 489 480 525 474 189 17 469 567 274 214 125 538 M17501 GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX.html Any of the heteromeric enzymes that act in the TCA cycle. 5/13 Gene Ontology CC GO:0045239 0.935349522045615 0.999999966915186 490 407.363636363636 470 0.239573621050531 201 0.694957063565193 -0.694957063565193 -1 3.27268111579903e-08 490 201 520 222 510 328 347 479 470 481 433 539 M17657 GO_REPLISOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLISOME.html A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. 21/29 Gene Ontology CC GO:0030894 0.99963000309398 0.999999966915186 525 464.454545454545 472 0.512451293679319 360 0.181809043560455 0.19413812045156 1 4.25148429590267e-09 360 472 369 425 526 524 399 437 523 534 540 540 M17745 GO_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_PREINITIATION_COMPLEX.html A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. 7/16 Gene Ontology CC GO:0070993 0.97805785598086 0.999999966915186 415 465.363636363636 472 0.317460317460317 300 0.256534054902022 0.235538205630293 1 8.39808340526823e-09 412 300 565 433 517 509 373 536 451 551 472 541 M17781 GO_CYTOSOLIC_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_RIBOSOME.html A ribosome located in the cytosol. 67/214 Gene Ontology CC GO:0022626 0.726156069079962 0.887353505133653 425 434.181818181818 474 0.11107745696593 156 0.147048699917411 0.133007162132525 1 0.0294760564692799 299 500 423 514 422 474 156 463 487 559 479 542 M17546 GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX.html RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 6/22 Gene Ontology CC GO:0005665 0.822191453465134 0.94694903204241 465 470.090909090909 476 0.158614035322641 321 0.161190655126481 -0.143766523989166 -1 0.0147371427532386 419 518 532 464 321 468 463 476 514 499 497 543 M17841 GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT.html A distinct region of the endoplasmic reticulum 10/22 Gene Ontology CC GO:0098827 0.751985672431077 0.903424291007479 545 448.090909090909 476 0.119047619047619 309 0.237669147297758 0.173812153569461 1 0.0404860574224938 541 413 352 309 476 560 500 348 335 577 518 544 M17804 GO_METHYLOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLOSOME.html A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. 6/17 Gene Ontology CC GO:0034709 0.992645824806987 0.999999966915186 575 492.636363636364 477 0.388138119474686 429 0.111194623693875 -0.124598857623369 -1 3.32987861172203e-10 492 486 574 453 429 470 440 461 572 565 477 545 M17010 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX.html A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. 15/54 Gene Ontology CC GO:0005891 0.77338263439933 0.917895611258342 375 410.090909090909 482 0.126243761249051 193 0.284090031801668 0.343662180242435 1 0.0408216176584992 375 552 193 513 317 492 525 217 502 343 482 546 M17502 GO_STAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAGA_COMPLEX.html A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. 6/17 Gene Ontology CC GO:0030914 0.822436702569706 0.94694903204241 565 455.727272727273 482 0.158730158730159 340 0.287879814769949 -0.278396255280035 -1 0.0263199294167658 561 354 521 340 410 500 420 504 370 482 551 547 M17526 GO_U2_TYPE_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. 7/18 Gene Ontology CC GO:0071004 0.301273555054501 0.487776231993001 355 433.181818181818 482 0.0352146103636104 122 0.193369335295336 0.244992073470281 1 0.232834863455975 351 517 528 482 391 533 445 122 503 489 404 548 M17528 GO_SCHMIDT_LANTERMAN_INCISURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHMIDT_LANTERMAN_INCISURE.html Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. 7/21 Gene Ontology CC GO:0043220 0.818374931625108 0.946303972968662 495 446.636363636364 482 0.156825276116202 313 0.290262945279009 -0.243689949162757 -1 0.0268695605923656 559 364 529 313 318 482 471 493 385 491 508 549 M17611 GO_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUCHROMATIN.html A dispersed and relatively uncompacted form of chromatin. 25/56 Gene Ontology CC GO:0000791 0.641826931941396 0.820743289075502 525 413.272727272727 483 0.0891161682917444 224 0.257180894075551 -0.285436334546073 -1 0.0852122143342728 522 483 224 511 266 391 232 517 515 521 364 550 M17576 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE.html The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 12/24 Gene Ontology CC GO:0031304 0.879544388557771 0.989059643164186 380 447.454545454545 484 0.175028735342171 200 0.129761047999722 -0.12487149249639 -1 0.00239419048811248 377 554 372 527 516 457 200 363 560 512 484 551 M17783 GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX.html A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. 9/24 Gene Ontology CC GO:0000159 0.914646340226712 0.999999966915186 425 475.727272727273 484 0.21815220670139 281 0.246750463034788 0.233203708083451 1 7.85517772222149e-09 425 449 572 451 484 539 441 281 507 561 523 552 M17666 GO_MHC_CLASS_II_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. 4/11 Gene Ontology CC GO:0042613 0.386086746459241 0.574203784463481 560 386.727272727273 485 0.0476190476190476 83 1.70932184675759 1.70932184675759 1 1.59050445180502 556 104 551 136 485 556 565 460 208 83 550 553 M17396 GO_SAGA_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_TYPE_COMPLEX.html A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. 11/36 Gene Ontology CC GO:0070461 0.986831624970353 0.999999966915186 540 468.909090909091 488 0.325396825396825 309 0.236981298785615 -0.272432340074368 -1 7.31307264859756e-09 536 473 309 502 529 542 330 488 452 442 555 554 M17493 GO_HEMOGLOBIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_COMPLEX.html An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. 3/15 Gene Ontology CC GO:0005833 0.52340095663996 0.710154349619476 490 425.727272727273 488 0.0714285714285714 266 0.573350098975936 -0.632682227037205 -1 0.329146928375606 494 293 519 285 525 488 489 358 266 476 490 555 M17714 GO_CYTOPLASMIC_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE.html Any microtubule in the cytoplasm of a cell. 37/84 Gene Ontology CC GO:0005881 0.988274936301354 0.999999966915186 520 461 489 0.33247886759606 185 0.294569236477789 -0.276631069575732 -1 1.05087107202071e-08 562 559 185 516 489 388 518 424 473 547 410 556 M17672 GO_RNAI_EFFECTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNAI_EFFECTOR_COMPLEX.html Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. 4/11 Gene Ontology CC GO:0031332 0.962211491749219 0.999999966915186 580 462.545454545455 491 0.279330778031964 243 0.269512080549097 -0.22209903621067 -1 9.1182528455042e-09 577 243 552 302 482 577 481 321 525 537 491 557 M17464 GO_BETA_CATENIN_DESTRUCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX.html A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. 7/18 Gene Ontology CC GO:0030877 0.515549995138838 0.702801644316623 495 449.181818181818 493 0.0699101682421658 169 0.321681376402494 0.30861799561054 1 0.190285113587393 493 360 509 380 543 538 527 169 393 466 563 558 M17289 GO_NUCLEAR_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_REPLICATION_FORK.html The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 30/42 Gene Ontology CC GO:0043596 0.992245835863558 0.999999966915186 345 454.181818181818 495 0.35710574550194 281 0.187853837669089 0.212485336721238 1 4.5869186761343e-09 281 495 342 485 540 530 345 499 543 424 512 559 M17846 GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX.html A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. 30/70 Gene Ontology CC GO:0030532 0.970917022999725 0.999999966915186 375 461.818181818182 496 0.275012021282215 345 0.162226130566257 -0.149701429037554 -1 3.16480009040490e-09 373 551 392 560 509 345 359 496 542 578 375 560 M17053 GO_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). 57/168 Gene Ontology CC GO:0015934 0.970129705694686 0.999999966915186 360 462.818181818182 497 0.273249382853883 316 0.153123355843589 -0.169357340086284 -1 2.65967393679035e-09 513 523 417 543 563 497 356 316 519 358 486 561 M17548 GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 8/20 Gene Ontology CC GO:0000780 0.997902932585456 0.999999966915186 500 483.363636363636 497 0.460289037821455 409 0.258314282275822 -0.266593124610472 -1 8.49687080068157e-09 429 459 533 497 519 422 538 475 536 500 409 562 M17338 GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX.html A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. 5/19 Gene Ontology CC GO:0033276 0.999881377623498 0.999999966915186 475 510.090909090909 498 0.595035772005934 428 0.20017713600425 -0.134645209199048 -1 5.27075634953994e-09 471 498 488 472 498 553 563 537 547 428 556 563 M17539 GO_DNA_HELICASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_COMPLEX.html A protein complex that possesses DNA helicase activity. 12/18 Gene Ontology CC GO:0033202 0.998201802646972 0.999999966915186 560 483.636363636364 498 0.437088968832376 317 0.183593886536803 -0.200991739425751 -1 4.35052781778659e-09 549 474 317 498 557 442 523 403 556 494 507 564 M17478 GO_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. 10/24 Gene Ontology CC GO:0071010 0.784420420413404 0.925295924487648 525 460.181818181818 499 0.130201058923629 223 0.184050654036054 -0.143423041079903 -1 0.0239678738401092 525 477 319 499 552 414 526 223 509 472 546 565 M17417 GO_EXTERNAL_ENCAPSULATING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_ENCAPSULATING_STRUCTURE.html A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space. 7/13 Gene Ontology CC GO:0030312 0.99871082531708 0.999999966915186 505 499.727272727273 501 0.48591944530182 424 0.170992045177674 0.124336144697098 1 3.65123338854558e-09 571 493 501 437 560 424 552 445 561 448 505 566 M17418 GO_CELL_TRAILING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_TRAILING_EDGE.html The area of a motile cell opposite to the direction of movement. 7/27 Gene Ontology CC GO:0031254 0.999280911273404 0.999999966915186 510 495 502 0.51507089816222 418 0.275744829240009 0.298207760527033 1 9.46411709773563e-09 418 506 502 510 544 481 494 428 578 449 535 567 M17107 GO_SMN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_COMPLEX.html A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. 9/13 Gene Ontology CC GO:0032797 0.999722747726245 0.999999966915186 450 498.090909090909 503 0.5591533837831 374 0.110067471975792 0.0643272773234685 1 2.70440579794645e-10 523 573 449 563 569 445 457 446 577 374 503 568 M17563 GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR.html A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. 14/26 Gene Ontology CC GO:0030687 0.906356691367126 0.999999966915186 575 471.636363636364 513 0.193697722803193 216 0.137360258664315 -0.115716522730071 -1 1.78495684339783e-09 381 569 354 572 388 513 216 562 574 507 552 569 M17566 GO_GAMMA_TUBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_COMPLEX.html A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. 7/25 Gene Ontology CC GO:0000930 0.987945623895701 0.999999966915186 525 506.090909090909 516 0.357142857142857 448 0.243844717237014 0.177457351615379 1 7.69393367928626e-09 521 516 536 448 530 490 460 535 463 508 560 570 M17704 GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX.html Any complex formed of proteins that act in nucleotide-excision repair. 11/16 Gene Ontology CC GO:0000109 0.999217581649245 0.999999966915186 565 496.818181818182 521 0.478102320144814 296 0.15509858014319 0.1543612640294 1 2.76928199404557e-09 460 537 296 521 466 562 436 505 562 544 576 571 M17618 GO_LATERAL_ELEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_ELEMENT.html A proteinaceous core found between sister chromatids during meiotic prophase. 8/115 Gene Ontology CC GO:0000800 0.982920762458482 0.999999966915186 510 508.545454545455 524 0.334348602865906 405 0.295424323030761 -0.313607542281623 -1 1.05561607115196e-08 508 450 545 481 405 510 524 539 533 525 574 572 M17503 GO_SPERM_MIDPIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MIDPIECE.html The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. 8/16 Gene Ontology CC GO:0097225 0.999695838844282 0.999999966915186 555 513.545454545455 530 0.555050856649556 407 0.147024765164937 0.107136257593659 1 2.32125430697067e-09 446 545 522 489 546 554 407 554 573 483 530 573 M17540 GO_CHROMOCENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOCENTER.html A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure. 8/17 Gene Ontology CC GO:0010369 0.905915227395072 0.999999966915186 550 501.181818181818 531 0.210500364277983 351 0.213614798133836 -0.171683690381764 -1 6.01643168391754e-09 497 547 531 548 351 573 355 486 552 495 578 574 M17737 GO_COHESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_COHESIN_COMPLEX.html A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). 8/14 Gene Ontology CC GO:0008278 0.982153851147574 0.999999966915186 550 502.727272727273 532 0.331418352459545 350 0.155339914450026 -0.184308182952312 -1 2.78267398427506e-09 461 575 563 532 527 505 362 350 546 550 559 575 M17553 GO_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATION_FORK.html The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 49/81 Gene Ontology CC GO:0005657 0.999999966915186 0.999999966915186 535 517.090909090909 533 0.791086625090446 316 0.209755382066263 -0.21540648373178 -1 5.80226709643668e-09 499 533 316 533 565 521 541 569 559 504 548 576 M17734 GO_ESCRT_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_III_COMPLEX.html An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. 8/12 Gene Ontology CC GO:0000815 0.993697669137976 0.999999966915186 565 508.545454545455 541 0.397509615807446 318 0.168751982935719 -0.144349629709653 -1 3.52692909028383e-09 502 505 562 483 578 564 318 427 541 549 565 577 M17140 GO_GEMINI_OF_COILED_BODIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_GEMINI_OF_COILED_BODIES.html Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). 8/11 Gene Ontology CC GO:0097504 0.999987157904886 0.999999966915186 575 517.454545454545 543 0.675762241642268 385 0.105193917802992 0.0643272773234685 1 0 572 574 455 549 561 485 503 489 576 385 543 578 M17187 GO_MCM_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MCM_COMPLEX.html A hexameric protein complex required for the initiation and regulation of DNA replication. 6/11 Gene Ontology CC GO:0042555 0.99999180371713 0.999999966915186 555 509.909090909091 549 0.69 393 0.182801693207031 -0.19000961666462 -1 4.30656786252257e-09 532 460 461 406 570 555 549 559 551 393 573