Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M17398 GO_EXTRACELLULAR_MATRIX_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_COMPONENT.html Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). 65/171 Gene Ontology CC GO:0044420 2.20045337120623e-24 1.81694578365315e-22 10 23.0909090909091 11 2.00041215564203e-25 3 2.62635036435503 2.84799414192731 1 47.9549155297274 3 17 6 10 121 11 8 21 21 8 28 2 M17302 GO_BASEMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE.html A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. 53/132 Gene Ontology CC GO:0005604 8.81685252392903e-20 5.66237862092331e-18 5 24 13 8.01532047629912e-21 1 2.61578501501165 2.7872632301748 1 37.8898961974097 5 19 8 1 125 12 7 23 22 13 29 3 M17343 GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX.html A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. 133/408 Gene Ontology CC GO:0005578 2.05769273238628e-47 5.94673199659635e-45 5 17.9090909090909 13 1.87062975671481e-48 1 2.5977986004129 2.76874975833457 1 96.4913098825404 1 13 2 33 58 13 12 17 24 3 21 4 M16984 GO_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX.html A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants). 172/559 Gene Ontology CC GO:0031012 1.27082672192632e-49 7.34537845273413e-47 5 19.0909090909091 15 1.15529701993303e-50 1 2.58090028888787 2.77875468675088 1 100 2 11 1 32 66 15 10 16 35 2 20 5 M17676 GO_NEUROMUSCULAR_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION.html The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. 55/122 Gene Ontology CC GO:0031594 2.28639640140703e-09 4.00465793943413e-08 20 28.6363636363636 16 2.07854218525747e-10 4 2.34246850444481 2.56914452564858 1 14.5533381820293 8 85 28 19 80 4 4 10 16 45 16 6 M17802 GO_MICROBODY_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_LUMEN.html The volume enclosed by the membranes of a microbody. 23/53 Gene Ontology CC GO:0031907 1.33855749701347e-08 1.48223149322516e-07 15 60.5454545454545 19 1.2168704592343e-09 2 1.23906941892856 -1.23906941892856 -1 7.10666323890689 13 23 178 128 13 2 19 9 55 222 4 7 M17077 GO_BASAL_LAMINA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_LAMINA.html A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. 18/46 Gene Ontology CC GO:0005605 3.13528944187028e-15 1.29442664100073e-13 25 26.9090909090909 20 2.85026312897298e-16 2 2.93893078516072 3.15983032370431 1 31.8111996341534 9 22 11 2 110 23 20 40 5 19 35 8 M17310 GO_COMPLEX_OF_COLLAGEN_TRIMERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEX_OF_COLLAGEN_TRIMERS.html A complex of collagen trimers such as a fibril or collagen network. 12/30 Gene Ontology CC GO:0098644 8.71065833715286e-10 1.62411629641108e-08 10 36.2727272727273 23 7.91878030963796e-11 5 3.32412818452714 3.32412818452714 1 21.7464599112955 6 50 25 13 201 7 5 25 8 36 23 9 M17128 GO_SITE_OF_POLARIZED_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_POLARIZED_GROWTH.html Any part of a cell where non-isotropic growth takes place. 108/272 Gene Ontology CC GO:0030427 1.76463467223618e-11 4.24982850230213e-10 15 31.0909090909091 24 1.60421333840939e-12 11 2.08816311797604 2.31640633872617 1 16.4356629688368 44 15 21 15 11 48 66 19 28 24 51 10 M17365 GO_BANDED_COLLAGEN_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BANDED_COLLAGEN_FIBRIL.html A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). 12/23 Gene Ontology CC GO:0098643 8.71065833715286e-10 1.62411629641108e-08 10 37.0909090909091 24 7.91878030963796e-11 6 3.32412818452714 3.32412818452714 1 21.7464599112955 7 51 26 14 202 8 6 24 9 37 24 11 M17697 GO_MICROBODY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_PART.html Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 54/112 Gene Ontology CC GO:0044438 4.8429513092546e-09 7.36638383355042e-08 5 94.8181818181818 27 4.40268301810509e-10 1 1.05069316967643 -1.05500781888661 -1 6.29419612628939 27 57 272 178 2 1 22 11 163 300 10 12 M17195 GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION.html Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. 17/43 Gene Ontology CC GO:0098636 2.53829735549164e-08 2.189755032051e-07 30 51.4545454545455 30 2.30754307707071e-09 4 2.16791383141741 2.52812296349462 1 12.1254583610308 30 102 101 24 77 30 24 4 13 143 18 13 M17408 GO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE.html The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. 361/1081 Gene Ontology CC GO:0045202 2.19281335795681e-11 5.06978448359615e-10 25 44.1818181818182 31 1.99346668907152e-12 15 1.77920243542572 1.99183230286291 1 13.8893836375325 23 31 22 49 128 26 38 28 88 15 38 14 M17654 GO_WNT_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALOSOME.html A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. 10/21 Gene Ontology CC GO:1990909 6.419124505522e-09 9.04939991266272e-08 10 81.3636363636364 31 5.83556774931965e-10 2 1.85170651750745 1.85170651750745 1 10.9537037444228 20 181 140 31 191 9 3 2 214 97 7 15 M17494 GO_DENDRITE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MEMBRANE.html The portion of the plasma membrane surrounding a dendrite. 12/37 Gene Ontology CC GO:0032590 4.14750470644862e-09 6.47907491980353e-08 35 57.7272727272727 32 3.77045883115238e-10 1 2.20711743374518 2.31550164640512 1 13.3251054258602 35 141 104 9 165 16 9 1 32 120 3 16 M17447 GO_LAMELLIPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a lamellipodium. 19/37 Gene Ontology CC GO:0031258 1.96363013964572e-08 1.92369189951733e-07 35 77.7272727272727 33 1.78511832470207e-09 2 2.14877246483402 2.14877246483402 1 12.1199287486461 33 306 142 92 33 24 2 3 39 164 17 17 M17511 GO_MEMBRANE_MICRODOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_MICRODOMAIN.html A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. 188/491 Gene Ontology CC GO:0098857 7.25557023922043e-12 2.2014691912312e-10 35 45.7272727272727 33 6.59597294476758e-13 16 1.80460929653511 2.14280151966813 1 14.6367978464421 26 55 16 25 25 66 62 35 129 31 33 18 M17362 GO_ENDOPLASMIC_RETICULUM_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_LUMEN.html The volume enclosed by the membranes of the endoplasmic reticulum. 95/258 Gene Ontology CC GO:0005788 2.26873519690322e-13 8.74219295873375e-12 40 27.2727272727273 34 2.0624865426395e-14 6 2.48759714984828 2.86503931631758 1 23.1035811455936 36 16 12 11 44 54 42 7 34 38 6 19 M17629 GO_NEURON_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a neuron projection. 18/74 Gene Ontology CC GO:0032589 7.05769601417483e-08 3.88509361542196e-07 90 54.6363636363636 34 6.41608749144438e-09 7 2.30308207060239 2.496113303239 1 12.3998293213598 31 88 89 7 164 43 30 8 19 88 34 20 M17845 GO_COLLAGEN_TRIMER http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_TRIMER.html A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. 29/89 Gene Ontology CC GO:0005581 1.17585290453489e-19 6.43241166441611e-18 55 46.1818181818182 36 1.0689571859408e-20 4 3.2287049335105 3.17385952598395 1 46.6179421858513 4 59 9 43 195 36 15 51 25 16 55 21 M17628 GO_PLASMA_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_REGION.html A membrane that is a (regional) part of the plasma membrane. 437/1317 Gene Ontology CC GO:0098590 3.23303740987094e-31 4.67173905726351e-29 5 52.2727272727273 45 2.93912491806449e-32 3 1.95399764580421 2.14239394044469 1 46.4928732794888 32 5 3 34 45 105 71 84 125 5 66 22 M17016 GO_FILOPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a filopodium. 11/22 Gene Ontology CC GO:0031527 4.59097246449671e-08 2.90065502455919e-07 50 79.4545454545455 47 4.1736114184558e-09 5 2.94544577439217 2.94544577439217 1 16.1722605729493 47 272 110 81 134 42 16 6 14 147 5 23 M17334 GO_LEADING_EDGE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEADING_EDGE_MEMBRANE.html The portion of the plasma membrane surrounding the leading edge of a motile cell. 82/233 Gene Ontology CC GO:0031256 8.83701327547097e-09 1.08676461132388e-07 50 40.8181818181818 47 8.0336484645161e-10 6 1.91661288250934 2.18866677112779 1 11.2096594928905 48 81 69 6 7 47 18 15 79 64 15 24 M17227 GO_ACTIN_FILAMENT_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE.html An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. 46/106 Gene Ontology CC GO:0032432 1.25220371456295e-07 5.34414391067974e-07 40 53.8181818181818 48 1.13836707803303e-08 30 2.5704569092526 2.95701879549243 1 13.5404325289951 40 67 36 44 115 67 56 38 30 51 48 25 M17384 GO_CELL_SUBSTRATE_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION.html A cell junction that forms a connection between a cell and the extracellular matrix. 303/642 Gene Ontology CC GO:0030055 2.66330983972958e-08 2.22506195774589e-07 5 56.6363636363636 49 2.42119079270135e-09 2 1.76876548759724 2.06792904715289 1 9.88264368278845 16 153 90 52 49 22 27 5 97 110 2 26 M17561 GO_ANCHORING_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORING_JUNCTION.html A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. 349/772 Gene Ontology CC GO:0070161 5.3588470099562e-08 3.19441819745759e-07 55 47.7272727272727 49 4.87167921862649e-09 9 1.75725756011612 2.02274196587471 1 9.58656300772016 25 53 53 65 72 34 39 13 113 49 9 27 M17263 GO_NEURON_SPINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_SPINE.html A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. 76/235 Gene Ontology CC GO:0044309 9.48434125353751e-08 4.6066800374325e-07 55 59 52 8.62212878401231e-09 30 2.14483475874354 2.39038936064695 1 11.4145463975185 53 96 52 30 99 68 44 49 38 74 46 28 M17284 GO_ACTOMYOSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN.html Any complex of actin, myosin, and accessory proteins. 47/116 Gene Ontology CC GO:0042641 8.9562721106208e-08 4.50150024342506e-07 45 61 53 8.14206588657599e-09 29 2.54522524420442 2.9603147298046 1 13.5668178890539 29 120 63 46 94 62 53 41 41 80 42 29 M17824 GO_SYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_MEMBRANE.html A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 103/356 Gene Ontology CC GO:0097060 1.17052314205318e-07 5.24466958222279e-07 70 56.2727272727273 53 1.06411200393779e-08 10 1.90567587866887 2.16347385651873 1 10.051615459213 10 137 66 53 109 18 17 39 66 63 41 30 M17307 GO_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION.html A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. 635/1673 Gene Ontology CC GO:0030054 4.96188152719417e-10 1.02427411525651e-08 45 98.5454545454545 54 4.96188152830207e-11 12 1.7786453358981 1.96068296946004 1 11.9349670729765 41 42 486 94 82 41 55 54 150 12 27 31 M17831 GO_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE.html A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. 252/725 Gene Ontology CC GO:0030425 9.36486160684117e-09 1.12768541849046e-07 35 71.1818181818182 54 8.51351058791371e-10 27 1.88342662281922 2.25433035079553 1 10.9901714664303 99 54 33 27 31 196 122 43 74 28 76 32 M16974 GO_FILOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM.html Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. 78/172 Gene Ontology CC GO:0030175 3.24339511052857e-09 5.35623535395861e-08 55 52.6363636363636 55 2.94854101391838e-10 18 2.19593216365949 2.44290316345892 1 13.4100120746887 55 37 30 18 55 82 73 87 27 35 80 33 M17177 GO_POSTSYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPSE.html The part of a synapse that is part of the post-synaptic cell. 184/552 Gene Ontology CC GO:0098794 3.46324131307529e-07 1.1915199279509e-06 15 73.2727272727273 56 3.14840168932642e-08 15 1.79181719418756 2.01912163946834 1 8.91474655165058 15 136 67 114 157 39 32 56 86 50 54 34 M17336 GO_CONTRACTILE_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_FIBER.html Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. 110/299 Gene Ontology CC GO:0043292 5.39145164989994e-12 1.7312550298012e-10 30 67.3636363636364 56 4.90131968173923e-13 15 2.15050481949927 2.33824701801496 1 17.6307546943119 19 94 15 140 28 70 47 117 126 29 56 35 M17474 GO_EXTRACELLULAR_SPACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_SPACE.html That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. 587/2139 Gene Ontology CC GO:0005615 6.61934398096505e-37 1.2753269403326e-34 5 90.6363636363636 57 6.61934398096498e-38 1 2.18773732255332 2.34505357775235 1 62.2774238456659 12 2 514 56 16 100 64 57 111 1 64 36 M17765 GO_TERMINAL_BOUTON http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINAL_BOUTON.html Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. 38/105 Gene Ontology CC GO:0043195 7.00433515905314e-09 9.63929933793504e-08 115 64.2727272727273 58 6.36757743759408e-10 1 1.85611330157986 1.79333337547221 1 10.9370186099791 83 100 112 106 4 33 37 58 58 115 1 37 M17803 GO_FILAMENTOUS_ACTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMENTOUS_ACTIN.html A two-stranded helical polymer of the protein actin. 19/46 Gene Ontology CC GO:0031941 2.04505361589385e-08 1.9377721147322e-07 195 110.727272727273 58 1.8591396680946e-09 4 3.14827932420422 4.04719355102505 1 17.7491705839512 191 24 40 4 26 379 249 91 6 58 150 38 M17084 GO_NEURON_PROJECTION_TERMINUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_TERMINUS.html The specialized, terminal region of a neuron projection such as an axon or a dendrite. 80/226 Gene Ontology CC GO:0044306 5.35020909133349e-09 7.73105213697689e-08 60 50.7272727272727 59 4.86382645849522e-10 3 1.91584911141795 2.02557560904049 1 11.4431656858188 60 95 62 59 3 35 43 53 68 67 13 39 M17531 GO_LAMELLIPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM.html A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. 129/281 Gene Ontology CC GO:0030027 7.49661382634491e-08 3.93912981057032e-07 60 64 59 6.81510371072355e-09 26 1.95558066827483 2.10598526764935 1 10.5190234800832 59 80 59 36 88 94 46 26 53 69 94 40 M17655 GO_ACTIN_BASED_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BASED_CELL_PROJECTION.html A cell projection supported by an assembly of actin filaments, and which lacks microtubules. 120/302 Gene Ontology CC GO:0098858 1.99564667542064e-09 3.60463680747853e-08 35 80.6363636363636 59 1.8142242520281e-10 26 2.00878287569049 2.25785086524725 1 12.5573156962509 100 35 27 26 53 190 112 111 59 34 140 41 M17160 GO_MICROBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY.html Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 81/169 Gene Ontology CC GO:0042579 3.99310273215845e-08 2.68373648742742e-07 255 132.909090909091 60 3.6300934587592e-09 3 1.09306382628859 -1.03359247690048 -1 6.03256205427598 52 155 264 253 60 3 45 47 254 304 25 42 M17559 GO_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_COMPLEX.html Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 124/450 Gene Ontology CC GO:0043235 8.93620007289302e-08 4.50150024342506e-07 105 69.7272727272727 60 8.12381857806671e-09 27 1.85398526873487 2.12404080877272 1 9.88229970351156 51 46 43 102 93 109 102 27 98 60 36 43 M17547 GO_CELL_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION.html A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. 241/593 Gene Ontology CC GO:0005911 1.60018043624305e-19 7.70753576790401e-18 65 70.8181818181818 63 1.45470948749368e-20 7 1.88376393108918 1.89925585367749 1 27.0746303271709 63 7 10 93 64 51 61 200 121 14 95 44 M17755 GO_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REGION.html A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane. 543/1581 Gene Ontology CC GO:0098589 4.21480828225796e-16 1.87396860549623e-14 65 108 63 4.21480828225798e-17 4 1.8795418334821 2.08539897054066 1 21.6692013110249 45 4 567 63 35 110 83 83 131 6 61 45 M16979 GO_I_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_BAND.html A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. 65/198 Gene Ontology CC GO:0031674 3.33102843705166e-08 2.39579213926491e-07 100 86.7272727272727 65 3.02820771589718e-09 37 2.31784401451614 2.67664288749703 1 12.8880155135528 42 249 37 104 47 99 97 64 92 65 58 46 M17008 GO_CELL_CELL_CONTACT_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_CONTACT_ZONE.html Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. 48/126 Gene Ontology CC GO:0044291 1.29114764532374e-07 5.44732364231474e-07 50 74.1818181818182 65 1.17377065554482e-08 41 2.07198086770369 2.07651246136605 1 10.900150425948 46 132 65 48 120 46 41 99 76 90 53 47 M17182 GO_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON.html The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. 238/668 Gene Ontology CC GO:0030424 8.75111818912244e-09 1.08676461132388e-07 100 63.8181818181818 65 7.95556202175678e-10 6 1.74852670757048 2.05007400224869 1 10.2265766546053 97 33 35 16 6 125 118 97 80 30 65 48 M17775 GO_SYNAPSE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_PART.html Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 288/866 Gene Ontology CC GO:0044456 6.92733657994974e-08 3.85000052231822e-07 70 59.8181818181818 66 6.29757890734271e-09 6 1.73406150728819 1.95876557176402 1 9.34195231802313 61 6 38 66 83 73 92 69 90 20 60 49 M17296 GO_COSTAMERE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COSTAMERE.html Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. 11/29 Gene Ontology CC GO:0043034 4.69923508303188e-08 2.90065502455919e-07 35 75 67 4.27203198491664e-09 3 2.54990913449779 2.93774047908803 1 14.0005272783064 64 126 120 37 67 107 90 31 3 148 32 50 M17433 GO_CELL_CELL_ADHERENS_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHERENS_JUNCTION.html An adherens junction which connects a cell to another cell. 33/93 Gene Ontology CC GO:0005913 1.00695687273465e-07 4.7640810693998e-07 70 61.8181818181818 68 9.15415380748948e-09 14 2.36541631205016 2.6509640100669 1 12.5594675277735 34 122 70 22 101 86 57 14 20 68 86 51 M17491 GO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE.html The external part of the cell wall and/or plasma membrane. 354/1190 Gene Ontology CC GO:0009986 1.57824874029412e-27 1.82445554378e-25 35 68.6363636363636 68 1.43477158208555e-28 4 2.00039634263977 2.29993983207331 1 41.5626885023491 68 32 4 35 46 172 78 81 147 7 85 52 M17174 GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE.html The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 9/16 Gene Ontology CC GO:0031231 1.38896375044037e-08 1.48670564398988e-07 70 150.727272727273 69 1.38896375912186e-09 1 0.886058304634378 -0.886058304634378 -1 5.08099868855684 69 25 460 221 259 6 1 12 230 356 19 53 M17678 GO_SOMATODENDRITIC_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATODENDRITIC_COMPARTMENT.html The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. 373/1027 Gene Ontology CC GO:0036477 1.0114110515508e-12 3.65372242372725e-11 20 73.5454545454545 69 9.19464592319328e-14 13 1.90561152775459 2.21936723498089 1 16.704319851049 108 43 13 17 20 209 134 71 104 21 69 54 M17595 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE.html A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. 25/42 Gene Ontology CC GO:0030140 1.63064555185611e-07 6.54523006231131e-07 50 125.818181818182 72 1.48240515701816e-08 5 1.07170814264859 -1.12576601817168 -1 5.5662009972895 50 72 224 154 129 5 25 33 351 315 26 55 M17166 GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 599/2062 Gene Ontology CC GO:0031226 1.22416138942175e-19 6.43241166441611e-18 5 105.818181818182 73 1.22416138942175e-20 3 1.95865218092044 2.1074991613456 1 28.2801719709416 21 3 459 185 91 81 50 73 152 4 45 56 M17632 GO_SARCOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOLEMMA.html The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. 69/199 Gene Ontology CC GO:0042383 5.73783177126466e-08 3.28363045919898e-07 50 73.6363636363636 73 5.21621083719396e-09 28 1.90317756941259 2.0093525531409 1 10.3634959775157 28 131 49 97 76 50 59 78 117 52 73 57 M17680 GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. 104/420 Gene Ontology CC GO:0009897 4.6801264531608e-12 1.59124299407467e-10 25 79.1818181818182 74 4.25466041197341e-13 14 2.15938976030442 2.32227232978516 1 17.7700191004157 22 56 14 116 154 90 40 80 183 42 74 58 M17691 GO_PERIKARYON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIKARYON.html The portion of the cell soma (cell body) that excludes the nucleus. 80/202 Gene Ontology CC GO:0043204 2.63205342369261e-08 2.22506195774589e-07 150 105.636363636364 76 2.39277586834744e-09 33 1.86341556320359 2.29223681543706 1 10.4114832770796 57 324 99 148 34 76 33 36 166 150 39 59 M17136 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. 12/26 Gene Ontology CC GO:0033177 1.23671073893915e-07 5.34414391067974e-07 115 112.545454545455 78 1.12428255314524e-08 8 0.806602511082633 -0.806602511082633 -1 4.24894973360964 73 103 305 115 113 10 14 29 78 390 8 60 M17740 GO_CELL_LEADING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_LEADING_EDGE.html The area of a motile cell closest to the direction of movement. 234/544 Gene Ontology CC GO:0031252 4.46019902239656e-08 2.8644389277169e-07 60 77.4545454545455 78 4.0547264662009e-09 34 1.75583455798045 1.96467727893537 1 9.64862826423005 82 78 55 57 65 156 87 34 93 56 89 61 M17801 GO_PLASMA_MEMBRANE_RAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RAFT.html A membrane raft that is part of the plasma membrane. 63/155 Gene Ontology CC GO:0044853 1.26068721670126e-06 3.4698914821587e-06 80 95.1818181818182 78 1.14607994465963e-07 11 1.74110069954494 1.87234771163936 1 7.98360549970932 11 156 75 105 205 80 31 45 194 78 67 62 M17414 GO_POSTSYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE.html A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. 73/268 Gene Ontology CC GO:0045211 5.11769885773305e-07 1.67410182522662e-06 90 96.2727272727273 83 4.65245458929658e-08 17 1.9946159929508 2.3574531510219 1 9.67632776304742 17 214 86 156 168 83 35 66 62 89 83 63 M17746 GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. 7/34 Gene Ontology CC GO:0034361 1.95642834341562e-06 5.16354147257639e-06 85 140.363636363636 84 1.95643006584309e-07 42 2.53828437008805 2.73433818375036 1 11.2709776809455 84 75 566 109 215 130 81 88 42 84 70 64 M17840 GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE.html A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood. 7/34 Gene Ontology CC GO:0034385 1.95642834341562e-06 5.16354147257639e-06 85 142.363636363636 85 1.95643006584309e-07 43 2.53828437008805 2.73433818375036 1 11.2709776809455 85 76 578 110 216 131 82 89 43 85 71 65 M17139 GO_MYOFILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFILAMENT.html Any of the smallest contractile units of a myofibril (striated muscle fiber). 16/34 Gene Ontology CC GO:0036379 1.67117371971098e-07 6.66164420684792e-07 115 98.9090909090909 87 1.51924895150676e-08 41 2.99350210332676 3.16148057273078 1 15.5283038559559 70 87 41 64 130 160 114 218 47 46 111 66 M17092 GO_GLYCOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_COMPLEX.html A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. 9/23 Gene Ontology CC GO:0090665 5.35638952552793e-06 1.18167677318899e-05 40 138.545454545455 88 5.35640243648066e-07 11 2.36145899451691 2.36145899451691 1 9.77270627242727 38 237 448 117 258 88 70 48 11 169 40 67 M17827 GO_ANCHORED_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 56/186 Gene Ontology CC GO:0031225 7.61754045408719e-12 2.2014691912312e-10 20 76.8181818181818 90 6.9250367764669e-13 17 2.1074979821155 2.1619932987923 1 17.0934632713845 43 20 17 127 92 93 89 101 148 25 90 68 M17035 GO_BASOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASOLATERAL_PLASMA_MEMBRANE.html The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 114/324 Gene Ontology CC GO:0016323 2.42320296360134e-09 4.11944503812228e-08 95 117.545454545455 94 2.20291178751853e-10 29 1.99059680250823 2.0563213609721 1 12.3467029834853 94 93 29 150 159 102 86 277 180 41 82 69 M17419 GO_CATION_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_COMPLEX.html An ion channel complex through which cations pass. 62/225 Gene Ontology CC GO:0034703 5.31921114565502e-08 3.19441819745759e-07 155 102.545454545455 94 4.8356466129674e-09 28 1.88661664365553 1.95555008828564 1 10.2922702280421 77 144 47 28 71 155 94 199 151 66 96 70 M17635 GO_CELL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_BODY.html The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. 297/774 Gene Ontology CC GO:0044297 4.49396828744466e-10 9.62042100052968e-09 135 96.1818181818182 95 4.08542571669332e-11 17 1.95727808191151 2.29281228814805 1 13.1783677547812 135 154 23 45 17 260 132 95 106 39 52 71 M17648 GO_LAMELLAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLAR_BODY.html A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. 10/26 Gene Ontology CC GO:0042599 2.51681708500793e-05 5.0864345284426e-05 75 128.727272727273 95 2.28804170731999e-06 52 1.91275939918437 -1.91275939918437 -1 6.89744436445444 74 203 159 145 281 52 95 90 63 179 75 72 M17098 GO_EXOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE.html A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. 70/211 Gene Ontology CC GO:0070382 3.34159939606571e-08 2.39579213926491e-07 390 175.363636363636 96 3.0378176789287e-09 18 1.61048628203469 -1.37758042001277 -1 8.95486071570659 387 18 96 70 48 140 402 432 81 32 223 73 M17462 GO_NEURON_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION.html A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 512/1429 Gene Ontology CC GO:0043005 7.62779492306551e-09 1.00201487852997e-07 100 109.272727272727 96 7.62779494924796e-10 3 1.75307851680647 2.01096389157961 1 10.3051155218305 96 29 507 3 8 142 126 107 105 17 62 74 M17465 GO_APICOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICOLATERAL_PLASMA_MEMBRANE.html The apical end of the lateral plasma membrane of epithelial cells. 15/27 Gene Ontology CC GO:0016327 5.17880249202592e-07 1.68165609010729e-06 90 95.1818181818182 96 4.70800337374274e-08 36 2.61000877377088 -2.52651147240284 -1 12.657450294619 111 89 54 103 170 40 157 96 36 86 105 75 M17810 GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the plasma membrane. 221/687 Gene Ontology CC GO:0098797 6.62287539449916e-10 1.32000757862776e-08 25 92.4545454545455 96 6.02079581499357e-11 23 1.85137999293702 2.11746981642988 1 12.2517387385347 54 130 24 96 139 139 113 74 146 23 79 76 M17217 GO_INTERMEDIATE_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT.html A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. 48/224 Gene Ontology CC GO:0005882 3.35742497025014e-08 2.39579213926491e-07 105 106.818181818182 97 3.05220456498897e-09 34 2.84142728915162 3.08487547176336 1 15.7993204645573 102 202 34 80 196 112 69 108 84 91 97 77 M17327 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE.html A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. 29/77 Gene Ontology CC GO:0045334 2.01480948821192e-08 1.9377721147322e-07 25 118.181818181818 97 1.83164500605818e-09 23 2.02727347900828 2.08356791636283 1 11.4292335971472 150 48 97 23 24 286 107 268 82 122 93 78 M17725 GO_ACTIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT.html A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. 51/112 Gene Ontology CC GO:0005884 2.76408705585732e-08 2.22506195774589e-07 150 102.727272727273 98 2.51280644598673e-09 20 2.18254723687219 2.79473378193247 1 12.1945718139583 122 98 56 20 37 296 147 52 49 107 146 79 M17612 GO_CELL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX.html The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 156/408 Gene Ontology CC GO:0005938 1.77777542243446e-08 1.7716451623571e-07 70 140.090909090909 99 1.61615948800028e-09 21 1.67856747998531 1.88074850017653 1 9.5181970588676 151 34 60 67 21 376 195 189 99 70 279 80 M17763 GO_AXON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_PART.html A part of an axon, a cell projection of a neuron. 133/371 Gene Ontology CC GO:0033267 3.66051351382219e-09 5.8771578083034e-08 105 89.5454545454545 100 3.32773956355709e-10 1 1.64409887315183 1.79402493818282 1 9.98444511483601 103 64 88 39 1 148 119 168 100 53 102 81 M17141 GO_CELL_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a cell surface projection. 160/464 Gene Ontology CC GO:0031253 1.04711250671234e-08 1.23516536506068e-07 105 96.8181818181818 101 9.51920465178346e-10 9 1.91430372239621 2.22413979932069 1 11.1067797115979 123 92 48 29 9 251 101 104 143 55 110 82 M17573 GO_PODOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PODOSOME.html An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. 12/34 Gene Ontology CC GO:0002102 1.38600837668727e-07 5.80388066105253e-07 105 93.2727272727273 101 1.26000769455121e-08 4 2.58703191720991 2.69939761177929 1 13.5498729058763 101 180 113 51 122 120 75 82 4 166 12 83 M17722 GO_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE.html Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. 195/538 Gene Ontology CC GO:0030133 5.4877452148791e-08 3.20395629717184e-07 75 208.454545454545 101 4.9888594106973e-09 10 1.66350401603024 -1.34544813840715 -1 9.07328970894908 491 10 82 74 75 173 523 364 101 57 343 84 M17245 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX.html A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. 25/53 Gene Ontology CC GO:0016469 4.04623290150446e-06 9.35489046827832e-06 40 165.636363636364 102 3.6784003121292e-07 20 0.807240849257372 -0.807240849257372 -1 3.40948585586265 37 71 353 170 245 20 29 102 327 418 50 85 M17076 GO_MICROBODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_MEMBRANE.html The lipid bilayer surrounding a microbody. 36/69 Gene Ontology CC GO:0031903 1.32513823126958e-08 1.48223149322516e-07 65 157.727272727273 108 1.20467112659214e-09 12 0.876249075526453 -0.834112636501787 -1 5.02571206708783 118 108 334 282 12 19 63 44 324 368 63 86 M17690 GO_CORNIFIED_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORNIFIED_ENVELOPE.html A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). 7/67 Gene Ontology CC GO:0001533 2.11157675640985e-07 7.82239418766297e-07 150 145.090909090909 108 2.11157695705391e-08 42 1.76944949450937 -1.95412703056588 -1 9.07506226766347 149 170 555 108 148 75 155 42 52 83 59 87 M17674 GO_PRESYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPSE.html The part of a synapse that is part of the presynaptic cell. 132/414 Gene Ontology CC GO:0098793 3.62075788065454e-08 2.52144343978111e-07 420 245.272727272727 109 3.2915981274954e-09 14 1.61765315894541 1.74707793847667 1 8.96454988108881 416 14 98 76 54 341 452 561 109 48 529 88 M17656 GO_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION.html A prolongation or process extending from a cell, e.g. a flagellum or axon. 902/2503 Gene Ontology CC GO:0042995 1.68204160187956e-08 1.70564920330945e-07 110 150.090909090909 110 1.68204161461125e-09 22 1.64240795236065 1.87134195986607 1 9.33589911480106 109 115 550 180 22 229 110 61 162 22 91 89 M17142 GO_APICAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PART_OF_CELL.html The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. 212/594 Gene Ontology CC GO:0045177 8.09062391480155e-24 5.84547577844412e-22 10 127.181818181818 112 7.35511264981955e-25 7 2.02365459219855 2.1012570793984 1 36.0877002319473 88 9 7 95 112 272 152 333 140 10 181 90 M17601 GO_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL.html Extracellular matrix material consisting of polysaccharides and protein. 5/23 Gene Ontology CC GO:0043205 1.55459035582083e-07 6.3278396173552e-07 195 154 114 1.55459046457464e-08 10 2.2726336271678 3.06795991705556 1 11.8315291231927 223 77 542 50 133 195 194 60 10 96 114 91 M17240 GO_POTASSIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_COMPLEX.html An ion channel complex through which potassium ions pass. 31/123 Gene Ontology CC GO:0034705 1.09158267563802e-07 4.96799044502974e-07 95 145.545454545455 115 9.92347936181378e-09 92 1.72468195054067 1.78188778856495 1 9.13104433733634 132 139 92 99 105 184 115 358 168 94 115 92 M17091 GO_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. 239/581 Gene Ontology CC GO:0015629 2.51736599819726e-08 2.189755032051e-07 140 124.636363636364 119 2.28851457000219e-09 32 1.83111822713975 2.18094816373595 1 10.2417109951869 138 105 45 133 32 319 165 119 91 87 137 93 M17606 GO_APICAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the apical end of the cell. 170/492 Gene Ontology CC GO:0016324 3.16325018341248e-26 3.04726434335402e-24 120 150.272727272727 120 2.87568198492044e-27 5 2.11158083724759 2.20198464294907 1 41.7042776383198 120 12 5 79 114 359 184 430 120 9 221 94 M17733 GO_GOLGI_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LUMEN.html The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. 35/156 Gene Ontology CC GO:0005796 1.04901007488561e-11 2.88727534897087e-10 280 182 120 9.53645522627832e-13 18 2.40416178582977 2.56525102060145 1 19.2618318293444 278 86 18 120 59 450 217 373 71 26 304 95 M17825 GO_EXOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an exocytic vesicle 24/80 Gene Ontology CC GO:0099501 6.90426313902072e-08 3.85000052231822e-07 400 235.454545454545 121 6.27660305063394e-09 21 1.56830706453514 1.61090205785325 1 8.44897906770306 398 21 121 113 81 539 319 322 77 40 559 96 M17707 GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX.html Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). 27/45 Gene Ontology CC GO:0030119 5.49258665816888e-07 1.7443489496822e-06 115 154.181818181818 123 4.99326184496835e-08 45 0.962194414466428 -0.94030029863517 -1 4.65339269855092 114 123 269 137 175 45 60 62 279 345 87 97 M17754 GO_PROTEIN_LIPID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX.html A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. 17/64 Gene Ontology CC GO:0032994 1.02205199412729e-07 4.7640810693998e-07 125 222.363636363636 124 9.29138219644243e-09 61 2.49075975438582 2.42692066085214 1 13.22499402234 293 124 61 121 103 498 350 460 67 62 307 98 M17058 GO_INTERCALATED_DISC http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCALATED_DISC.html A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. 41/108 Gene Ontology CC GO:0014704 2.46642315104458e-07 8.85461230623458e-07 85 124.818181818182 125 2.2422031159597e-08 78 2.15189356711286 2.19799993678779 1 10.9392361598846 107 207 78 84 149 126 105 178 85 129 125 99 M17212 GO_CORTICAL_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON.html The portion of the cytoskeleton that lies just beneath the plasma membrane. 51/134 Gene Ontology CC GO:0030863 1.57173801680959e-07 6.35289911689472e-07 40 203.727272727273 127 1.42885284463519e-08 38 1.95197329351402 -1.51024479723437 -1 10.1593290479566 268 38 64 40 127 508 371 264 65 81 415 100 M17514 GO_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIDE_OF_MEMBRANE.html A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. 215/702 Gene Ontology CC GO:0098552 1.62334313471344e-11 4.07953187767116e-10 110 132.454545454545 127 1.47576648611401e-12 20 1.87913879627423 2.20179919961715 1 14.8184900125675 93 143 20 192 174 240 127 106 228 27 107 101 M17085 GO_CYTOPLASMIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_REGION.html Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\ 188/475 Gene Ontology CC GO:0099568 1.35913960451442e-08 1.48223149322516e-07 75 175 128 1.23558146628278e-09 14 1.60274288075134 1.82886660668954 1 9.19250745988788 189 44 80 75 14 472 252 247 128 71 353 102 M17257 GO_DENDRITIC_SHAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SHAFT.html Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. 20/67 Gene Ontology CC GO:0043198 2.43471717788206e-08 2.189755032051e-07 250 177.636363636364 128 2.21337927711529e-09 15 1.62117434463366 1.77825359205695 1 9.06746397229577 249 49 128 58 29 387 254 348 15 108 329 103 M17664 GO_CELL_PROJECTION_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_PART.html Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. 498/1408 Gene Ontology CC GO:0044463 1.11979287446768e-08 1.29448056288464e-07 45 109.181818181818 128 1.0179935274249e-09 10 1.72337183689829 1.93728912888696 1 9.9695096551056 141 116 42 41 10 263 146 140 130 44 128 104 M17744 GO_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_COMPLEX.html An ion channel complex through which calcium ions pass. 29/87 Gene Ontology CC GO:0034704 7.10283250441787e-07 2.17218898812356e-06 80 130.272727272727 128 6.45712254328288e-08 42 1.92202421006546 2.15969110292926 1 9.14157336956831 78 326 130 42 182 128 72 76 138 204 57 105 M17150 GO_NEURON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PART.html Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 647/1803 Gene Ontology CC GO:0097458 2.77861975683841e-10 6.17708545943308e-09 15 130.363636363636 130 2.77861975718584e-11 11 1.74017377223693 2.00409988488328 1 11.9978114819634 130 27 457 12 15 259 154 144 137 11 88 106 M17568 GO_PRESYNAPTIC_ACTIVE_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_ACTIVE_ZONE.html A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. 9/44 Gene Ontology CC GO:0048786 1.01599641114691e-07 4.7640810693998e-07 150 162.545454545455 130 1.01599645759811e-08 31 1.96757081841768 2.22669617804123 1 10.4470577213854 202 41 537 130 106 292 148 146 31 54 101 107 M17045 GO_SECRETORY_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE.html A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. 182/584 Gene Ontology CC GO:0030141 7.35657075417748e-09 9.88859975794089e-08 205 125.454545454545 131 6.68779161707007e-10 32 1.77102408290937 2.01062425863913 1 10.4191417385681 80 45 32 203 51 222 131 165 203 43 205 108 M17056 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. 12/18 Gene Ontology CC GO:0012510 2.6134629395361e-06 6.45547683355497e-06 230 171.454545454545 131 2.37587822197492e-07 74 1.10193173144343 -1.17292838038156 -1 4.80325465388304 127 231 228 131 230 74 103 110 266 302 84 109 M17813 GO_CENTRIOLAR_SATELLITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLAR_SATELLITE.html A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. 10/33 Gene Ontology CC GO:0034451 1.69748831025411e-07 6.6955333214336e-07 215 119.727272727273 131 1.54317131020898e-08 14 1.52585353059891 -1.52585353059891 -1 7.91229088082996 67 219 164 212 131 14 28 75 213 180 14 110 M17525 GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN.html The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. 14/28 Gene Ontology CC GO:0035327 9.16738517372212e-07 2.67613567192494e-06 280 149 132 8.33398999433417e-08 20 1.45430107141526 -1.45430107141526 -1 6.80630499202031 117 276 217 279 209 28 67 20 132 264 30 111 M17081 GO_PLATELET_ALPHA_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_MEMBRANE.html The lipid bilayer surrounding the platelet alpha granule. 10/16 Gene Ontology CC GO:0031092 2.87287132327313e-05 5.66730247389716e-05 60 159 134 2.61173530851496e-06 23 2.67162744716041 2.67162744716041 1 9.52856175185313 56 273 125 162 392 64 23 134 196 224 100 112 M17835 GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE.html A clathrin coat found on a vesicle of the trans-Golgi network. 11/16 Gene Ontology CC GO:0030130 1.77587482511162e-06 4.77421232053262e-06 135 168 134 1.61443296238864e-07 79 1.10193173144343 -1.17292838038156 -1 4.92451588158011 134 232 219 125 210 79 116 113 246 293 81 113 M17792 GO_NEURONAL_CELL_BODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_CELL_BODY_MEMBRANE.html The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. 12/44 Gene Ontology CC GO:0032809 5.36118863423726e-07 1.7120259837509e-06 125 129.454545454545 135 4.87380903700715e-08 50 1.72982605248298 1.93608576607302 1 8.37763857574913 121 148 139 135 173 180 128 50 60 167 123 114 M17010 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX.html A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. 15/54 Gene Ontology CC GO:0005891 7.74528050439695e-07 2.30761450079456e-06 140 141.090909090909 137 7.04116657380713e-08 18 2.31457516931882 2.8698504252342 1 10.9575749164605 137 248 115 21 272 256 191 18 64 158 72 115 M17416 GO_RUFFLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_MEMBRANE.html The portion of the plasma membrane surrounding a ruffle. 57/146 Gene Ontology CC GO:0032587 4.7173282406326e-08 2.90065502455919e-07 140 128.090909090909 137 4.28848031071222e-09 62 1.84960460742559 2.15292829611184 1 10.1554355612963 139 172 118 62 69 228 68 100 169 137 147 116 M17620 GO_INTERMEDIATE_FILAMENT_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_CYTOSKELETON.html Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. 85/303 Gene Ontology CC GO:0045111 1.96006622632464e-07 7.50277005838173e-07 140 128.727272727273 138 1.78187854632241e-08 68 2.09946797215299 2.41215952631445 1 10.799591592354 140 164 68 191 138 150 98 105 102 140 120 117 M17741 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated endocytic vesicle. 25/55 Gene Ontology CC GO:0030669 7.40300673368004e-08 3.93912981057032e-07 140 132.454545454545 138 6.73000634799224e-09 55 1.78456368321679 1.91263466912264 1 9.59912681502524 133 70 138 55 85 266 79 172 171 149 139 118 M17060 GO_EXCITATORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. 106/315 Gene Ontology CC GO:0060076 3.41798429000629e-05 6.69693193092759e-05 15 133.181818181818 142 3.10730672178556e-06 14 1.63566015722791 1.77681828814526 1 5.73411026291035 14 242 156 218 292 59 34 63 167 142 78 119 M17073 GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX.html Any protein complex that is part of the plasma membrane and which functions as a receptor. 71/236 Gene Ontology CC GO:0098802 7.95209456066068e-07 2.35708238772404e-06 115 178.909090909091 143 7.22917948637912e-08 97 1.86801957788009 2.13869856008621 1 8.8290559527901 162 97 111 143 186 380 259 125 123 113 269 120 M17012 GO_IMMUNOLOGICAL_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE.html An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 20/68 Gene Ontology CC GO:0001772 2.22722006921476e-06 5.77279461886158e-06 155 124.727272727273 144 2.02474756726807e-07 26 1.73372161361 2.15893537020271 1 7.62787223674356 153 161 144 173 218 122 26 65 72 201 37 121 M17105 GO_CELL_CORTEX_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_PART.html Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 75/185 Gene Ontology CC GO:0044448 2.24780027995101e-07 8.17124881642568e-07 85 212.181818181818 146 2.04345500874087e-08 76 1.75371192620549 -1.39039887760636 -1 8.96643907356239 231 83 76 83 146 494 342 242 114 125 398 122 M17280 GO_AXONAL_GROWTH_CONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_GROWTH_CONE.html The migrating motile tip of a growing nerve cell axon. 23/44 Gene Ontology CC GO:0044295 8.32344571250389e-07 2.4545671539935e-06 145 152.545454545455 146 7.56677169235003e-08 76 1.67572368955437 1.80901782991887 1 7.89541338843219 143 264 146 163 188 167 76 122 87 106 216 123 M17816 GO_CLATHRIN_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_ADAPTOR_COMPLEX.html A membrane coat adaptor complex that links clathrin to a membrane. 20/34 Gene Ontology CC GO:0030131 4.57297889598642e-07 1.51907000108055e-06 135 167.090909090909 146 4.15725440594395e-08 40 1.07343800638062 -1.08358106149026 -1 5.24553499016919 210 40 243 146 166 114 142 135 235 274 133 124 M17205 GO_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_COMPLEX.html An ion channel complex through which sodium ions pass. 3/17 Gene Ontology CC GO:0034706 2.33259022016667e-05 4.74731389878991e-05 320 227.818181818182 149 2.3326147049255e-06 98 2.75877024560659 -2.95020994197886 -1 10.0176053312655 319 142 465 123 282 320 367 126 115 98 149 125 M17273 GO_BLOOD_MICROPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_MICROPARTICLE.html A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. 66/447 Gene Ontology CC GO:0072562 5.36087482964335e-08 3.19441819745759e-07 225 190.909090909091 149 4.87352269115916e-09 44 2.17426125907528 2.4573137015557 1 11.8614903897374 225 84 44 129 73 439 176 371 149 92 318 126 M17436 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_.html All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. 8/16 Gene Ontology CC GO:0045263 0.00150863966351905 0.00238249651779784 150 241.090909090909 149 0.000150966484031758 77 0.483312878764669 -0.483312878764669 -1 1.06470192686175 142 149 504 149 345 101 77 205 316 534 130 127 M17686 GO_RUFFLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE.html Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. 112/276 Gene Ontology CC GO:0001726 4.30843765074829e-08 2.81975129671207e-07 65 173.363636363636 149 3.91676157738538e-09 61 1.67355445700253 1.83659507532953 1 9.20608230943138 198 163 95 61 62 408 136 149 186 130 319 128 M17616 GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT.html A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. 7/15 Gene Ontology CC GO:0044322 3.80964789504575e-06 8.91488454792083e-06 35 173.909090909091 150 3.8096544260992e-07 17 1.04594955532136 -1.04594955532136 -1 4.43608351083641 79 150 544 186 268 17 21 32 258 327 31 129 M17156 GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. 7/15 Gene Ontology CC GO:0016471 3.24305080726682e-05 6.37579376394632e-05 130 185 152 3.24309813644235e-06 49 0.855551505448501 -0.855551505448501 -1 3.01462824628048 128 204 458 152 288 49 52 72 216 318 98 130 M17005 GO_LYSOSOMAL_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_LUMEN.html The volume enclosed within the lysosomal membrane. 56/120 Gene Ontology CC GO:0043202 2.987845712298e-08 2.27307155709485e-07 275 191.818181818182 154 2.71622341170571e-09 40 1.98513883847686 2.22034069200007 1 11.0761323098889 154 145 87 274 40 412 273 137 195 127 266 131 M17158 GO_APICAL_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_COMPLEX.html A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. 77/174 Gene Ontology CC GO:0043296 7.80026595371499e-08 4.02549439397077e-07 495 248 155 7.09115111843574e-09 39 1.85941049796507 -1.87242172966108 -1 9.98701715703834 493 47 39 155 90 520 401 387 103 61 432 132 M17355 GO_CORTICAL_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_ACTIN_CYTOSKELETON.html The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. 43/106 Gene Ontology CC GO:0030864 3.65190431149844e-07 1.24164746590947e-06 55 157.818181818182 155 3.31991356154437e-08 39 2.03408338159316 -1.60650674319577 -1 10.0895085355174 186 39 51 54 160 428 248 155 46 59 310 133 M17798 GO_BASAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PART_OF_CELL.html The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. 35/84 Gene Ontology CC GO:0045178 5.22710515282903e-09 7.73105213697689e-08 95 163.818181818182 155 4.75191378658947e-10 31 2.26557871071751 2.13203200649893 1 13.5320643647089 91 69 31 122 198 281 192 377 155 47 239 134 M17320 GO_PLATELET_ALPHA_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet alpha granule. 29/92 Gene Ontology CC GO:0031093 1.25744562604229e-07 5.34414391067974e-07 160 174.636363636364 160 1.14313245264876e-08 84 1.96216145766254 2.19095026420143 1 10.3361052733983 92 160 84 261 119 236 156 181 249 154 229 135 M17752 GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. 11/23 Gene Ontology CC GO:0033176 8.93065748644174e-06 1.89081319676312e-05 295 155.636363636364 160 8.11881249060671e-07 25 1.13149476168277 -1.13149476168277 -1 4.48859429256715 72 227 223 160 265 25 51 59 294 292 44 136 M17360 GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX.html Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. 10/41 Gene Ontology CC GO:0005834 3.60289080803245e-06 8.46532880911688e-06 135 199.818181818182 161 3.2753606440179e-07 74 1.97368738753888 2.23271114484578 1 8.40805951914213 185 113 131 161 242 210 74 577 107 135 263 137 M17513 GO_TRANSPORTER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_COMPLEX.html A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. 102/394 Gene Ontology CC GO:1990351 3.18782223723476e-07 1.10333009168964e-06 100 198 161 2.89802063559411e-08 79 1.80268113990959 1.90105708678302 1 9.0193588737868 170 300 79 98 155 347 161 474 182 99 113 138 M17564 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. 49/112 Gene Ontology CC GO:0033116 9.35183799082637e-07 2.71626249180786e-06 150 231.909090909091 161 8.5016745146738e-08 45 2.18417709512484 2.77919197652269 1 10.2103575436414 331 146 106 111 190 568 336 150 45 161 407 139 M17065 GO_PLATELET_ALPHA_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE.html A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). 43/117 Gene Ontology CC GO:0031091 4.28746219653094e-06 9.83251437849438e-06 50 163.090909090909 163 3.89770050196294e-07 49 1.83338647452124 2.14822935031261 1 7.71024829825825 49 178 73 262 246 163 85 156 268 144 170 140 M17213 GO_MYOSIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_FILAMENT.html A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. 9/29 Gene Ontology CC GO:0032982 4.30808929349725e-06 9.83251437849438e-06 120 174.454545454545 165 4.30809764535506e-07 12 3.66017184408848 3.7260933007876 1 15.3927385036148 106 169 470 89 250 220 204 118 12 116 165 141 M17304 GO_BRUSH_BORDER http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER.html The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. 61/186 Gene Ontology CC GO:0005903 1.2533226569095e-07 5.34414391067974e-07 245 213.090909090909 166 1.13938429846391e-08 101 1.71163409190149 1.68419074850503 1 9.0163984363957 243 166 109 101 116 301 121 501 209 138 339 142 M17119 GO_SECRETORY_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_VESICLE.html A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. 230/739 Gene Ontology CC GO:0099503 1.62301737764342e-11 4.07953187767116e-10 20 149.818181818182 167 1.47547034332308e-12 8 1.75307627046942 2.05634416605514 1 13.8243874919213 167 8 19 86 23 410 229 193 173 18 322 143 M17110 GO_SCF_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). 15/37 Gene Ontology CC GO:0019005 1.00962122032085e-07 4.7640810693998e-07 490 294.272727272727 168 9.17837515140235e-09 44 1.70906987836477 -1.2011066292129 -1 9.07451503969611 490 168 161 88 102 479 524 504 44 159 518 144 M17647 GO_MAIN_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAIN_AXON.html The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. 33/108 Gene Ontology CC GO:0044304 1.40578424316151e-07 5.80388066105253e-07 125 167.272727272727 168 1.27798575726375e-08 88 1.43704048450153 1.62196769672791 1 7.52666124655367 125 251 168 171 123 182 88 248 178 155 151 145 M17671 GO_KERATIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATIN_FILAMENT.html A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. 20/107 Gene Ontology CC GO:0045095 5.12657479351403e-07 1.67410182522662e-06 140 270.181818181818 169 4.66052362558208e-08 50 2.67631385572961 3.14584557615019 1 12.9833972878875 393 140 50 139 169 556 470 365 96 109 485 146 M17785 GO_TRANS_GOLGI_NETWORK_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_MEMBRANE.html The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. 45/97 Gene Ontology CC GO:0032588 6.29632901001393e-07 1.9583188724127e-06 115 141.272727272727 172 5.72393710182154e-08 30 1.17653006476653 -1.35938078947634 -1 5.640316412698 112 58 220 172 178 31 193 30 271 242 47 147 M17624 GO_PSEUDOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOPODIUM.html A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. 14/28 Gene Ontology CC GO:0031143 2.30938763216766e-06 5.88029097529915e-06 310 203.090909090909 173 2.09944550580492e-07 112 1.33052592021498 -1.40325619996427 -1 5.84497364931614 309 173 160 112 222 164 308 166 310 184 126 148 M16998 GO_ER_TO_GOLGI_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE.html A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. 52/130 Gene Ontology CC GO:0030134 3.92121383532128e-06 9.10225540889839e-06 280 216.272727272727 174 3.56474620399302e-07 75 2.10036178246996 2.51420886588621 1 8.89212674432486 277 119 105 91 244 532 311 109 75 174 342 149 M17662 GO_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE.html Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. 154/351 Gene Ontology CC GO:0030135 4.34183158144247e-08 2.81975129671207e-07 440 247.727272727273 175 3.94711969739192e-09 38 1.70369609961865 2.08879412728033 1 9.37188899810237 436 79 119 38 63 355 484 301 145 175 530 150 M16988 GO_CYTOCHROME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX.html A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 7/29 Gene Ontology CC GO:0070069 3.51990223061637e-08 2.48110181621495e-07 5 176.909090909091 176 3.51990228637006e-09 1 2.44196644710897 3.10318982936126 1 13.5470148042215 176 228 430 5 57 362 298 46 1 234 109 151 M17215 GO_NEURONAL_POSTSYNAPTIC_DENSITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_POSTSYNAPTIC_DENSITY.html A postsynaptic density that is part of a neuron. 43/96 Gene Ontology CC GO:0097481 4.9441366452374e-06 1.10763991509582e-05 145 178 176 4.49467977854808e-07 83 1.75588207028614 2.05814538659069 1 7.30801383999467 145 216 167 118 252 271 186 176 83 191 153 152 M17264 GO_ENDOPLASMIC_RETICULUM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_PART.html Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. 607/1512 Gene Ontology CC GO:0044432 2.8156841648548e-08 2.22506195774589e-07 480 289.363636363636 177 2.81568420053115e-09 28 1.60936902934842 -1.23858422958273 -1 8.99204578551522 569 28 480 177 42 117 545 479 133 146 467 153 M17506 GO_DNA_PACKAGING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING_COMPLEX.html A protein complex that plays a role in the process of DNA packaging. 50/109 Gene Ontology CC GO:0044815 0.00146335843615849 0.00231731829068386 20 211 177 0.000133121155939447 18 1.72150642909556 -1.72150642909556 -1 3.80977328542949 18 340 143 361 352 158 183 133 356 100 177 154 M17403 GO_GOLGI_ASSOCIATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE.html Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. 60/113 Gene Ontology CC GO:0005798 2.6986646703304e-07 9.62856900895663e-07 170 197.090909090909 178 2.45333181942402e-08 44 1.16027227058276 -1.09944986698509 -1 5.8628257674338 178 201 323 167 150 44 170 195 304 337 99 155 M17271 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. 11/48 Gene Ontology CC GO:0034364 6.49428146076582e-07 2.00732336060034e-06 80 227.909090909091 180 5.90389397985772e-08 40 2.60370331396795 2.40847968361728 1 12.4587537042396 391 111 77 73 180 541 348 324 40 77 345 156 M17489 GO_MITOCHONDRIAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PART.html Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 580/1145 Gene Ontology CC GO:0044429 1.40120609301053e-07 5.80388066105253e-07 105 266.909090909091 180 1.40120618136257e-08 77 1.08520653088928 -0.869489604225425 -1 5.68389067342688 104 304 517 550 126 77 158 180 292 486 142 157 M17190 GO_CLATHRIN_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE.html A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. 92/208 Gene Ontology CC GO:0030136 2.20882243618529e-08 2.0591925292179e-07 135 211.090909090909 181 2.0080204166928e-09 27 1.5549405691295 -1.3390246121254 -1 8.7318753333893 409 65 133 60 27 133 385 384 210 181 335 158 M17023 GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 10/21 Gene Ontology CC GO:0031362 6.00975011312861e-07 1.88784541597192e-06 180 202.181818181818 182 5.46341068619586e-08 112 1.76760353421729 1.57490658908429 1 8.49756910817673 179 112 122 271 177 247 182 183 345 178 228 159 M17185 GO_CLATHRIN_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT.html A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. 38/66 Gene Ontology CC GO:0030118 7.32319453186888e-07 2.22779286285274e-06 340 211 183 6.65745179050903e-08 69 0.975255699721952 -0.984594512564557 -1 4.62953986794077 161 234 340 257 183 69 120 115 339 384 119 160 M17229 GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM.html The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. 8/22 Gene Ontology CC GO:0097038 8.52131455666256e-06 1.82419252361147e-05 140 219.181818181818 183 8.5213472325997e-07 103 1.34626715432652 -1.34626715432652 -1 5.35820190886559 172 183 473 138 266 103 138 265 293 251 129 161 M17738 GO_MITOCHONDRIAL_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ENVELOPE.html The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. 426/833 Gene Ontology CC GO:0005740 2.91180226867408e-07 1.02623275078879e-06 135 270.363636363636 185 2.64709332187701e-08 89 1.07080722235244 -0.859618158179995 -1 5.38586382516391 131 333 425 556 152 89 185 169 307 479 148 162 M17364 GO_LATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_PLASMA_MEMBRANE.html The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. 40/93 Gene Ontology CC GO:0016328 6.30185657904433e-07 1.9583188724127e-06 530 283.181818181818 187 5.72896216745403e-08 57 2.01305413414018 -1.69760956387292 -1 9.65063692941063 528 99 57 134 179 465 435 368 187 105 558 163 M16981 GO_MULTIVESICULAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY.html A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 17/51 Gene Ontology CC GO:0005771 8.65456204542497e-07 2.53925729048509e-06 395 249.272727272727 189 7.86778677276177e-08 57 1.60631450182811 -1.56726897300759 -1 7.54850750484809 392 110 127 100 189 466 238 406 57 111 546 164 M17743 GO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM.html The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). 834/2134 Gene Ontology CC GO:0005783 1.58028415279642e-08 1.66073498239333e-07 565 257.181818181818 189 1.58028416403426e-09 1 1.628514919613 -1.23273994029336 -1 9.27277838325704 420 1 564 157 19 189 454 255 134 75 561 165 M17011 GO_INFLAMMASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMASOME_COMPLEX.html A cytosolic protein complex that is capable of activating caspase-1. 4/12 Gene Ontology CC GO:0061702 1.19201745461181e-06 3.31243311906551e-06 120 165.181818181818 190 1.19201809401982e-07 13 1.33372825650342 1.33372825650342 1 6.13824008694348 119 190 435 270 276 53 13 22 197 193 49 166 M17479 GO_CHD_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHD_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. 7/23 Gene Ontology CC GO:0090545 1.69566810556241e-05 3.48788670823869e-05 190 215.545454545455 190 1.69568104450782e-06 115 1.36831934446626 -1.15738267730097 -1 5.12248062514444 260 174 516 194 277 115 188 120 206 190 131 167 M17818 GO_GAP_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION.html A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons. 11/35 Gene Ontology CC GO:0005921 0.00017075169032075 0.000310359990582998 90 191.545454545455 190 1.5524085868343e-05 85 2.29056391079803 2.35415812470495 1 6.74879533355866 87 258 85 223 310 191 106 163 382 112 190 168 M17468 GO_FILOPODIUM_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_TIP.html The end of a filopodium distal to the body of the cell. 20/35 Gene Ontology CC GO:0032433 7.70329909425824e-07 2.30699838159651e-06 275 228 191 7.00300162869947e-08 37 1.79387131048633 1.91293712115214 1 8.49265236971871 272 191 132 85 185 383 201 462 37 139 421 169 M17282 GO_APICAL_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_DENDRITE.html A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. 9/30 Gene Ontology CC GO:0097440 0.000144932895661685 0.000265940360928426 155 231.272727272727 192 1.44942349024339e-05 117 2.03606171816209 2.21988591922499 1 6.11365337334507 241 192 483 151 309 367 251 159 119 117 155 170 M17357 GO_GLIAL_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_PROJECTION.html A prolongation or process extending from a glial cell. 7/32 Gene Ontology CC GO:0097386 0.000242927780230732 0.000432037713764194 155 228.727272727273 192 2.42954340575129e-05 78 1.1471515478772 1.36068598642672 1 3.24149968933654 157 151 492 78 316 213 151 313 192 321 132 171 M17490 GO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION.html A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 994/2090 Gene Ontology CC GO:0005739 2.82798714696129e-08 2.22506195774589e-07 150 260 192 2.82798718295008e-09 43 1.22237572580623 -0.998887838287772 -1 6.82979308442026 146 309 518 565 43 60 173 192 264 469 121 172 M17766 GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 21/45 Gene Ontology CC GO:0046658 3.13718280083156e-07 1.09234437281966e-06 105 186.545454545455 194 2.85198477108314e-08 86 1.90306011403273 1.96025301482252 1 9.52853144756482 194 101 103 289 153 278 210 86 238 145 255 173 M17381 GO_CLATHRIN_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_VESICLE_COAT.html A clathrin coat found on a vesicle. 20/32 Gene Ontology CC GO:0030125 5.42011702100248e-08 3.19676289606065e-07 220 197.363636363636 196 4.92737923139757e-09 74 1.08826906857035 -1.10751816395979 -1 5.93666327458356 218 217 260 126 74 147 168 196 281 332 152 174 M17791 GO_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a transport vesicle. 81/216 Gene Ontology CC GO:0030658 1.0141983169952e-06 2.88771737548388e-06 200 204.454545454545 196 9.21998895036503e-08 66 1.41247768421057 -1.45554058344851 -1 6.57136373274075 265 66 153 124 197 193 416 312 234 93 196 175 M17199 GO_HOPS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOPS_COMPLEX.html A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. 12/16 Gene Ontology CC GO:0030897 9.01762911773566e-06 1.90225898906978e-05 65 175.909090909091 197 8.19787825500827e-07 11 0.814051124553451 -0.814051124553451 -1 3.22751541806416 62 218 281 197 303 37 11 70 286 393 77 176 M17527 GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX.html A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. 10/26 Gene Ontology CC GO:0034663 0.00109945016496701 0.00177014539094966 200 227.272727272727 197 1e-04 8 4.39353459956901 4.39353459956901 1 10.1547389602315 197 328 149 8 522 442 257 130 50 281 136 177 M17623 GO_ACROSOMAL_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_VESICLE.html A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. 44/154 Gene Ontology CC GO:0001669 2.82974193583165e-08 2.22506195774589e-07 270 216.636363636364 197 2.57249270202646e-09 38 1.39568480804956 1.64994683307138 1 7.79812516607365 266 68 157 183 38 448 278 186 290 197 272 178 M17255 GO_MICROVILLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS.html Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. 48/118 Gene Ontology CC GO:0005902 2.02892054286107e-07 7.66481093969737e-07 145 287.545454545455 199 1.84447339088688e-08 74 1.87852543811028 -1.82457962759557 -1 9.64842968650079 422 167 74 141 141 540 340 569 199 76 494 179 M17808 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX.html A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. 14/28 Gene Ontology CC GO:0045259 0.0012799167514604 0.00203799416623722 120 261.090909090909 199 0.000116423817175112 116 0.482986936831973 -0.482986936831973 -1 1.0914983453916 116 197 379 199 339 118 137 250 404 575 158 180 M17236 GO_NUCLEAR_NUCLEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_NUCLEOSOME.html A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. 29/61 Gene Ontology CC GO:0000788 0.0030662394110913 0.0046885883058486 25 216.818181818182 200 0.000279138302263679 24 1.64067876786338 -1.64067876786338 -1 3.2091694136014 24 287 152 329 390 187 200 147 346 121 202 181 M17059 GO_LATE_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a late endosome. 72/129 Gene Ontology CC GO:0031902 4.01495973118354e-07 1.34141429169022e-06 230 190.727272727273 202 3.64996405809684e-08 61 1.2726820304289 -0.901428969010666 -1 6.27691008626672 226 106 202 229 163 61 198 276 231 219 187 182 M17446 GO_VACUOLAR_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_LUMEN.html The volume enclosed within the vacuolar membrane. 75/197 Gene Ontology CC GO:0005775 2.98881381209703e-08 2.27307155709485e-07 230 215.909090909091 203 2.71710350245602e-09 41 1.92887865868158 2.06739898053349 1 10.7622271399525 228 82 81 227 41 495 347 203 161 114 396 183 M17659 GO_CILIARY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_MEMBRANE.html The portion of the plasma membrane surrounding a cilium. 36/102 Gene Ontology CC GO:0060170 8.59216744499869e-06 1.83257298273404e-05 455 251.181818181818 206 7.8110918201414e-07 135 1.74824002615318 -1.53356053455135 -1 6.9551494681967 454 223 174 195 264 206 489 269 156 198 135 184 M17774 GO_COATED_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_MEMBRANE.html A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. 59/109 Gene Ontology CC GO:0048475 4.47357184919267e-06 1.01004864407553e-05 210 200.090909090909 206 4.0668917690603e-07 21 1.0102563710463 -0.931727571418875 -1 4.23869148633346 158 206 355 210 249 21 125 141 301 367 68 185 M17799 GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX.html Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. 5/14 Gene Ontology CC GO:0005890 2.57225815695503e-05 5.1623792177778e-05 340 239.181818181818 207 2.5722879317442e-06 68 1.76357321020886 0.997828994233951 1 6.34994272039367 339 127 573 168 287 274 150 68 94 207 344 186 M17375 GO_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_COMPLEX.html A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. 18/74 Gene Ontology CC GO:0016459 1.47993035122996e-06 4.01596123479305e-06 190 231.090909090909 208 1.34539213343051e-07 51 3.17091083627503 3.7260933007876 1 14.3707898688486 205 293 94 187 208 384 323 308 51 186 303 187 M17515 GO_PHOTORECEPTOR_CONNECTING_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CONNECTING_CILIUM.html A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments. 22/62 Gene Ontology CC GO:0032391 5.21093007048744e-07 1.68263551996745e-06 295 214.636363636364 208 4.73721027704647e-08 36 1.08280665408852 1.08132718991166 1 5.25092761790128 126 208 299 291 171 121 36 437 240 294 138 188 M17622 GO_ENDOSOMAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOMAL_PART.html Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. 283/614 Gene Ontology CC GO:0044440 1.00441655869566e-06 2.87402361844601e-06 195 226.363636363636 208 9.13106379332118e-08 91 1.4384889995208 -1.22111400471697 -1 6.69487196221454 204 253 194 290 194 91 351 260 250 208 195 189 M17305 GO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MATRIX.html The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. 262/496 Gene Ontology CC GO:0005759 9.96202535495421e-07 2.86470181848932e-06 75 255.636363636364 210 9.05639078723159e-08 71 1.01694460822712 -0.863291473986797 -1 4.73416638997013 71 270 410 510 193 84 153 210 297 470 144 190 M17154 GO_ROUGH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM.html The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. 47/110 Gene Ontology CC GO:0005791 2.12476797138942e-07 7.82239418766297e-07 230 204.636363636364 211 1.93160743327301e-08 69 1.95011478138719 2.67755464380765 1 10.0016494420268 211 259 117 69 144 491 230 220 110 229 171 191 M17176 GO_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COAT.html A membrane coat found on a coated vesicle. 31/55 Gene Ontology CC GO:0030120 1.70284324956875e-07 6.6955333214336e-07 180 224.181818181818 211 1.54803943761108e-08 119 1.28159232732482 -1.2480718394828 -1 6.6456776047632 342 179 258 119 132 178 246 349 211 243 209 192 M17144 GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE.html The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 75/180 Gene Ontology CC GO:0031227 2.74716657874581e-05 5.455901287385e-05 265 240 212 2.49745534867862e-06 29 1.28755880161643 -0.890296433786445 -1 4.61002798648964 264 195 288 209 285 29 100 532 212 365 161 193 M17186 GO_BASAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 22/58 Gene Ontology CC GO:0009925 1.85630320211853e-06 4.94443894389175e-06 355 251.545454545455 212 1.68754978947372e-07 46 2.26036382135288 -2.51359401855202 -1 10.0726491804209 353 60 46 142 212 496 333 464 135 73 453 194 M17767 GO_AXONEMAL_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX.html A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 3/21 Gene Ontology CC GO:0005858 1.76715106802747e-06 4.77295942672841e-06 560 283.818181818182 213 1.76715247329935e-07 2 2.47190794454941 -4.1185261433479 -1 11.0471583513646 560 128 569 82 213 528 450 164 2 248 178 195 M17021 GO_SPERM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PART.html Any constituent part of a sperm, a mature male germ cell that develops from a spermatid. 70/232 Gene Ontology CC GO:0097223 1.61466657156758e-08 1.66656656851082e-07 215 235.181818181818 214 1.46787871219841e-09 18 1.40481728054234 1.49034066785172 1 7.99724555316249 214 298 172 400 18 356 177 222 334 213 183 196 M17602 GO_NONMOTILE_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM.html A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 70/208 Gene Ontology CC GO:0031513 2.05839392442184e-07 7.70718078776042e-07 200 243.272727272727 214 1.87126737910192e-08 138 1.34929905492517 1.68880397048618 1 6.92751817539804 273 138 197 220 142 470 197 292 175 214 358 197 M17625 GO_T_TUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_TUBULE.html Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. 26/87 Gene Ontology CC GO:0030315 1.11512364179161e-06 3.11372688384325e-06 265 263.181818181818 216 1.01374927910875e-07 151 1.88762202279371 -1.63013499080488 -1 8.73002856709254 262 408 151 164 203 365 209 266 190 216 461 198 M17684 GO_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENVELOPE.html A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. 635/1396 Gene Ontology CC GO:0031975 1.05955891769791e-07 4.89940043543513e-07 185 295 218 1.05955896821784e-08 96 1.13859487439313 -0.944330437012019 -1 6.0338757411195 182 392 553 569 108 96 218 167 317 484 159 199 M17281 GO_PROTEIN_DNA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX.html A macromolecular complex containing both protein and DNA molecules. 88/191 Gene Ontology CC GO:0032993 0.00263966721447658 0.00409042265406827 215 261.090909090909 219 0.0002402581587549 90 1.56301772377373 -1.57493657794358 -1 3.13507418678645 90 365 212 442 346 197 219 179 383 228 211 200 M17519 GO_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of a membrane. 502/1255 Gene Ontology CC GO:0098796 8.51934063223852e-08 4.35768042958749e-07 510 288.181818181818 219 8.51934095884476e-09 32 1.48334746938464 -1.07360217583933 -1 7.92425634932063 506 129 525 200 98 32 436 570 219 195 260 201 M17544 GO_SARCOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASM.html The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. 33/102 Gene Ontology CC GO:0016528 8.28800437117202e-06 1.78084257492098e-05 260 214.090909090909 219 7.53457781320545e-07 96 1.57579869148378 1.53854302469753 1 6.2855715305552 156 256 147 204 262 219 96 282 287 260 186 202 M17603 GO_NUCLEAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MATRIX.html The dense fibrillar network lying on the inner side of the nuclear membrane. 54/158 Gene Ontology CC GO:0016363 7.69946536194965e-07 2.30699838159651e-06 255 225.545454545455 220 6.99951641506975e-08 26 2.34149901531012 3.4583117555653 1 11.0852648668763 255 346 134 68 184 565 395 55 26 220 233 203 M17453 GO_PRESYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_MEMBRANE.html A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. 23/95 Gene Ontology CC GO:0042734 7.16939394815842e-05 0.000136312819145907 225 211.727272727273 221 6.51784326921327e-06 104 1.41479343501927 1.3690623576791 1 4.59306029752118 165 224 205 202 297 234 104 170 229 221 278 204 M17108 GO_GOLGI_STACK http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_STACK.html The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. 80/184 Gene Ontology CC GO:0005795 3.52938224591519e-07 1.20709049594022e-06 205 230.363636363636 222 3.20852982920148e-08 58 1.11629310393679 -1.01410565749848 -1 5.54855499167939 201 247 293 350 158 58 222 123 378 388 116 205 M17341 GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS.html A cell part consisting of multiple, closely packed actin-based cell projections. 75/238 Gene Ontology CC GO:0098862 1.25504863993338e-07 5.34414391067974e-07 225 285.363636363636 222 1.14095337411907e-08 117 1.70462263437344 -1.77830990826598 -1 8.97946407431908 362 222 126 153 117 493 261 444 222 182 557 206 M17088 GO_SECRETORY_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_LUMEN.html The volume enclosed by the membrane of a secretory granule. 40/169 Gene Ontology CC GO:0034774 1.42642586942404e-07 5.84733441508577e-07 105 199.181818181818 224 1.29675087446363e-08 72 2.09001226551277 2.15564046627453 1 10.9409893428545 105 262 72 340 124 246 143 285 224 104 286 207 M17666 GO_MHC_CLASS_II_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. 4/11 Gene Ontology CC GO:0042613 0.000116103334793532 0.000216377862925591 225 264.272727272727 224 1.16109401232572e-05 124 1.37782525219928 -1.37782525219928 -1 4.24082581155646 224 212 551 232 306 223 208 225 408 194 124 208 M17682 GO_LYTIC_VACUOLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_MEMBRANE.html The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. 178/391 Gene Ontology CC GO:0098852 1.90138821628266e-07 7.37585495980792e-07 230 204.727272727273 224 1.72853489146679e-08 91 1.25814729590254 -1.08428551508832 -1 6.47969483583243 187 91 229 201 136 134 296 227 282 245 224 209 M17124 GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription. 10/28 Gene Ontology CC GO:0090568 1.78829791786878e-06 4.78535276170443e-06 210 242.909090909091 225 1.62572670137372e-07 186 1.23053729774501 -1.15738267730097 -1 5.49820636025095 371 210 232 283 211 186 289 214 243 225 208 210 M17599 GO_SUPRAMOLECULAR_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPRAMOLECULAR_FIBER.html A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. 288/821 Gene Ontology CC GO:0099512 2.45628595084689e-08 2.189755032051e-07 230 223.181818181818 226 2.23298725297378e-09 30 1.76600760888188 2.24041698294237 1 9.8775377278583 244 378 71 226 30 570 226 112 177 162 259 211 M17009 GO_MUSCLE_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_MYOSIN_COMPLEX.html A filament of myosin found in a muscle cell of any type. 7/27 Gene Ontology CC GO:0005859 2.30046263967428e-06 5.88029097529915e-06 190 255 228 2.30046502113551e-07 124 2.62885103319735 2.6281258601206 1 11.5484923877102 234 199 434 188 228 343 227 352 124 188 288 212 M17822 GO_PLATELET_DENSE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE.html Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. 13/31 Gene Ontology CC GO:0042827 0.000145874055873619 0.000266820266756177 230 250 228 1.32621571957719e-05 132 1.82107315214708 1.61519834671108 1 5.46591591613265 175 226 137 281 308 298 228 361 188 132 416 213 M17129 GO_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. 174/423 Gene Ontology CC GO:0030139 2.26384312099184e-07 8.17813327458302e-07 370 304.363636363636 229 2.05803941267797e-08 93 1.65792972287853 -1.58447018390586 -1 8.47621108215853 370 229 93 144 147 527 334 539 217 177 571 214 M17604 GO_AXOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXOLEMMA.html The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. 6/34 Gene Ontology CC GO:0030673 0.00115730067402679 0.0018581105266319 230 243.272727272727 230 0.000115790382133736 7 2.52699955660252 3.03794827374064 1 5.79592954030214 227 252 543 47 338 415 263 182 7 172 230 215 M17101 GO_PERINUCLEAR_REGION_OF_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_REGION_OF_CYTOPLASM.html Cytoplasm situated near, or occurring around, the nucleus. 405/983 Gene Ontology CC GO:0048471 7.84674422894897e-09 1.007870703185e-07 430 252.545454545455 233 7.13340386994179e-10 5 1.4979448271089 -1.23821325934955 -1 8.80217990216972 428 30 116 214 5 303 432 403 233 136 478 216 M17701 GO_PERICENTRIOLAR_MATERIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIOLAR_MATERIAL.html A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. 11/25 Gene Ontology CC GO:0000242 2.70050675773909e-06 6.64209747222637e-06 235 246.636363636364 233 2.45500915693194e-07 185 1.16862576760817 -1.02419222953154 -1 5.08182239001435 261 268 222 313 231 185 232 270 300 233 198 217 M17052 GO_AUTOPHAGOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME.html A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. 51/88 Gene Ontology CC GO:0005776 4.7098039255178e-08 2.90065502455919e-07 225 238 237 4.28164002395112e-09 68 1.13765411836513 -1.00352838006528 -1 6.24640053070403 221 147 297 346 68 161 239 427 237 250 225 218 M17313 GO_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 149/357 Gene Ontology CC GO:0005667 7.17949043819092e-08 3.91485422007014e-07 165 277.090909090909 238 6.52680970226068e-09 84 1.37898157296601 1.75137536435593 1 7.42061870681991 307 238 190 490 84 459 346 162 227 163 382 219 M17417 GO_EXTERNAL_ENCAPSULATING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_ENCAPSULATING_STRUCTURE.html A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space. 7/13 Gene Ontology CC GO:0030312 0.000401668756033337 0.000693028480559011 220 274 238 4.01741376513264e-05 145 2.00639143564207 2.00639143564207 1 5.32362065897104 216 362 501 273 323 329 145 230 208 189 238 220 M17488 GO_VACUOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PART.html Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. 433/967 Gene Ontology CC GO:0044437 1.18014406083371e-07 5.24710205509143e-07 175 257.454545454545 239 1.0728582946728e-08 111 1.46164857730041 -1.18666487669515 -1 7.70931579804978 330 171 171 275 111 174 453 412 239 187 309 221 M17581 GO_DESMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DESMOSOME.html A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. 14/36 Gene Ontology CC GO:0030057 5.91902362353711e-06 1.2864169149477e-05 240 237.727272727273 239 5.38094504411333e-07 37 2.04217095142945 -2.51953843677959 -1 8.38809864769488 347 239 166 239 294 265 508 37 165 183 172 222 M17717 GO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOST.html Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. 7/20 Gene Ontology CC GO:0018995 2.03361428751695e-06 5.33590922413077e-06 410 270.545454545455 239 2.03361614853353e-07 17 2.11766154953731 -1.0433561641189 -1 9.37788364255867 406 193 561 71 219 526 270 190 17 239 284 223 M17445 GO_LATE_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME.html A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. 132/279 Gene Ontology CC GO:0005770 2.82893761081301e-07 1.00314474788339e-06 305 241.272727272727 240 2.57176179507337e-08 98 1.26690540611574 -1.00508120575223 -1 6.38269885919895 302 159 186 240 151 98 353 443 263 185 274 224 M17530 GO_AXON_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_CYTOPLASM.html Any cytoplasm that is part of a axon. 20/40 Gene Ontology CC GO:1904115 2.39139857476818e-06 6.03593177386902e-06 275 257 240 2.17400106747349e-07 166 1.04180357184933 -0.818035852019341 -1 4.56669460720196 377 313 271 224 224 166 213 188 338 273 240 225 M16983 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. 7/18 Gene Ontology CC GO:0034362 3.01296749975873e-07 1.05545164537003e-06 315 227.636363636364 243 3.01296790826759e-08 23 2.91570546059421 2.98825778489739 1 14.6353388926301 313 74 429 87 156 440 324 243 23 82 333 226 M17057 GO_ENDOSOME_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_LUMEN.html The volume enclosed by the membrane of an endosome. 22/42 Gene Ontology CC GO:0031904 3.84205747159371e-06 8.95447265556921e-06 275 260.727272727273 243 3.49278561939995e-07 123 2.02523441173005 -2.32121926051217 -1 8.58615798079172 357 133 123 238 243 371 498 272 201 157 275 227 M17197 GO_TRANS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. 116/247 Gene Ontology CC GO:0005802 3.68212537423824e-08 2.53365293608298e-07 280 260.454545454545 244 3.34738675987793e-09 36 1.22316304263987 -1.21127793570042 -1 6.77624788184499 376 36 204 276 56 235 569 357 280 244 232 228 M17431 GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of an organellar ribosome. 19/29 Gene Ontology CC GO:0000314 0.00340900357579292 0.00517166421734464 225 287.909090909091 244 0.000310390679572714 95 0.583816437788697 -0.580295606564162 -1 1.12106179090875 95 225 380 250 351 181 221 226 462 532 244 229 M17518 GO_CLATHRIN_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated vesicle. 44/104 Gene Ontology CC GO:0030665 1.14688831858649e-07 5.17891756361711e-07 110 299.545454545455 244 1.04262579852296e-08 77 1.52408735872468 1.76855517839212 1 8.04591405807432 430 107 163 77 107 446 501 475 244 196 549 230 M17191 GO_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_COMPLEX.html A protein complex which is capable of protein kinase activity. 50/131 Gene Ontology CC GO:1902911 1.06173204246393e-06 2.97903456574831e-06 250 271.636363636364 246 9.65211413510883e-08 175 1.28818620735517 1.45513160322492 1 5.97848581539725 237 243 246 363 200 443 337 175 225 271 248 231 M17759 GO_MEDIATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEDIATOR_COMPLEX.html A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. 19/36 Gene Ontology CC GO:0016592 2.92098128077924e-06 7.09381168189245e-06 170 244.363636363636 247 2.65544105366192e-07 124 1.03043014171528 -1.16961488008038 -1 4.45614326707993 168 275 345 305 234 124 247 148 322 386 134 232 M17070 GO_SARCOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the sarcoplasmic reticulum. 17/45 Gene Ontology CC GO:0033017 4.41472761536643e-06 1.00067159281639e-05 110 247.090909090909 248 4.01339679490942e-07 54 1.1524323757623 0.95304641531813 1 4.83913455419525 110 314 175 327 248 138 54 439 393 366 154 233 M17347 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. 8/16 Gene Ontology CC GO:0033178 0.00398550158490327 0.0059834283534392 185 298 251 0.00039926675798763 135 0.85530859493823 -0.85530859493823 -1 1.59690519769791 184 296 489 251 355 170 135 198 475 524 201 234 M17194 GO_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LUMEN.html The volume enclosed by the membrane or protein that forms a vesicle. 54/213 Gene Ontology CC GO:0031983 9.29397571124747e-08 4.55247284839071e-07 140 218.363636363636 252 8.44906918534065e-09 58 2.17057376378826 2.28596899859992 1 11.560897618743 136 261 58 362 97 306 164 353 252 101 312 235 M17232 GO_ORGANELLE_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. 301/618 Gene Ontology CC GO:0019866 5.17364337526879e-06 1.14573405015531e-05 90 290.363636363636 253 4.70332321994432e-07 89 0.939224450462197 -0.803747595526503 -1 3.89748442266526 89 353 421 553 253 108 199 209 371 481 157 236 M17437 GO_CONNEXON_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNEXON_COMPLEX.html An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. 9/20 Gene Ontology CC GO:0005922 0.000453223266023131 0.000775038602844289 245 267.454545454545 253 4.53315727662541e-05 118 2.31070184369061 2.39522909429741 1 6.03679459333325 129 292 505 243 325 253 169 283 380 118 245 237 M17301 GO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. 257/549 Gene Ontology CC GO:0000785 1.33985153775837e-06 3.67030421243763e-06 200 280.636363636364 254 1.21804759432731e-07 151 1.53893293235376 -1.30282522551897 -1 7.02507058104292 196 420 200 555 206 151 272 254 305 308 220 238 M17262 GO_CELL_CORTEX_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_REGION.html The complete extent of cell cortex that underlies some some region of the plasma membrane 8/25 Gene Ontology CC GO:0099738 5.03387192322949e-06 1.1213822003868e-05 565 314 256 5.03388332620578e-07 90 1.84851244482997 -1.49793765813439 -1 7.68522961753797 563 157 479 90 256 437 538 228 112 153 441 239 M17642 GO_NUCLEAR_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PERIPHERY.html The portion of the nuclear lumen proximal to the inner nuclear membrane. 61/182 Gene Ontology CC GO:0034399 3.04222083333985e-06 7.32668184029347e-06 275 267 256 2.76565912746826e-07 33 2.34149901531012 3.4583117555653 1 10.0983392850021 274 445 148 159 236 563 440 77 33 256 306 240 M17709 GO_MYOSIN_II_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_II_COMPLEX.html A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. 8/31 Gene Ontology CC GO:0016460 6.32457053311131e-05 0.000121448563725526 235 267 256 6.32475054118762e-06 109 2.62885103319735 2.6281258601206 1 8.64515563032129 233 279 558 215 296 327 109 337 127 200 256 241 M17786 GO_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME.html A vacuole to which materials ingested by endocytosis are delivered. 468/1101 Gene Ontology CC GO:0005768 2.14082321665711e-07 7.83161910903676e-07 475 313.545454545455 256 1.94620311361905e-08 145 1.42505535879953 -1.19337840407576 -1 7.30813806388308 474 255 176 345 145 205 537 529 256 165 362 242 M17574 GO_CILIARY_BASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASE.html Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. 13/25 Gene Ontology CC GO:0097546 4.80565228110367e-06 1.08080428734549e-05 255 348.909090909091 257 4.36878434412915e-07 125 1.0908945398578 -0.996120839603242 -1 4.5500813097638 468 125 253 184 251 552 553 510 157 257 528 243 M17796 GO_PHOTORECEPTOR_OUTER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT.html The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes. 33/111 Gene Ontology CC GO:0001750 5.92018857052054e-06 1.2864169149477e-05 145 303.636363636364 260 5.38200409252477e-07 103 1.7733419412179 -1.24369252019298 -1 7.28389874288461 433 188 141 175 260 546 361 456 141 103 536 244 M17839 GO_PRIMARY_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_LYSOSOME.html A lysosome before it has fused with a vesicle or vacuole. 12/68 Gene Ontology CC GO:0005766 0.00220561442853896 0.00343624026872108 235 295.363636363636 261 0.000200711707304733 188 0.808608974619612 0.928493720070893 1 1.67329170428491 245 348 261 234 344 353 253 233 392 398 188 245 M17848 GO_VACUOLAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_MEMBRANE.html The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. 371/795 Gene Ontology CC GO:0005774 1.89945409586966e-07 7.37585495980792e-07 270 239.727272727273 261 1.72677659987847e-08 106 1.34418276962085 -1.10529709403198 -1 6.92279386311178 229 235 266 278 135 106 365 279 270 261 213 246 M17270 GO_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an endocytic vesicle. 102/230 Gene Ontology CC GO:0030666 2.5473786810757e-06 6.31924840198177e-06 165 298.090909090909 263 2.3158014824443e-07 162 1.59012456482058 1.80003787730839 1 6.94362971625049 263 351 162 165 229 513 255 363 255 285 438 247 M17407 GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE.html The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 26/65 Gene Ontology CC GO:0031228 0.000122945585861395 0.000227764578935533 215 261.272727272727 263 1.1177496103094e-05 169 1.55465692786111 1.46436020987498 1 4.75601635373748 183 263 169 296 305 285 215 388 319 215 236 248 M17782 GO_PHOTORECEPTOR_DISC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_DISC_MEMBRANE.html Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment. 9/33 Gene Ontology CC GO:0097381 7.65534150761812e-06 1.65104007141913e-05 435 334.909090909091 263 7.65536787966009e-07 119 1.7725773556712 2.0656311537579 1 7.11941692987639 434 182 571 136 263 523 236 497 189 119 534 249 M17619 GO_CYTOPLASMIC_VESICLE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_VESICLE_PART.html Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. 331/882 Gene Ontology CC GO:0044433 9.05323027628535e-08 4.51100612042494e-07 310 283.363636363636 266 8.23020968075935e-09 83 1.5604340647012 -1.38298788773842 -1 8.31638233575844 310 194 83 236 95 544 266 420 273 124 572 250 M17049 GO_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEMBRANE.html The lipid bilayer surrounding any membrane-bounded vesicle in the cell. 295/700 Gene Ontology CC GO:0012506 1.07388865287176e-07 4.92625112190381e-07 460 297.909090909091 267 9.76262459356024e-09 104 1.48570207535835 -1.34542266789111 -1 7.87037654537896 457 186 129 181 104 409 389 547 267 156 452 251 M17614 GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME.html Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. 50/110 Gene Ontology CC GO:0016591 5.3969011274089e-06 1.18608701583359e-05 375 291.545454545455 267 4.90628578799231e-07 154 1.00532677987121 -0.743399559829518 -1 4.15909570115861 267 335 371 373 254 165 212 370 154 449 257 252 M17286 GO_ORGANELLAR_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_RIBOSOME.html A ribosome contained within a subcellular membrane-bounded organelle. 52/80 Gene Ontology CC GO:0000313 0.00294616066044305 0.00451692536269518 210 273.818181818182 268 0.00026819213321583 39 0.631635617897867 -0.632266161291058 -1 1.24407175929285 39 290 403 268 348 154 205 207 434 457 207 253 M17685 GO_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_CILIUM.html A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors. 108/307 Gene Ontology CC GO:0072372 1.46932689330391e-06 4.00599502042293e-06 325 302.090909090909 268 1.33575261330254e-07 177 1.20588556515974 -0.927371843218557 -1 5.46624904228221 325 177 278 237 207 559 288 259 226 268 499 254 M17169 GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. 35/63 Gene Ontology CC GO:0030660 3.15305016696548e-06 7.53083882853738e-06 275 250.181818181818 269 2.86641335085511e-07 144 1.31130026693649 -1.18308010094472 -1 5.64218585795094 271 336 259 166 238 144 281 303 323 269 162 255 M17308 GO_NUCLEAR_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. 177/368 Gene Ontology CC GO:0000790 1.10964681856156e-05 2.3238255837992e-05 270 293.727272727273 270 1.00877492317479e-06 180 1.6149823973422 -1.29164676529952 -1 6.28510260098863 247 389 180 517 270 194 293 350 253 270 268 256 M17583 GO_ORGANELLE_ENVELOPE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ENVELOPE_LUMEN.html The region between the inner and outer lipid bilayers of an organelle envelope. 61/115 Gene Ontology CC GO:0031970 9.93240963631559e-06 2.08761191628742e-05 195 322 271 9.0295040716029e-07 193 0.834464195445623 -0.813182054231786 -1 3.28014857798066 193 355 390 501 269 208 265 271 435 441 214 257 M17038 GO_CATION_TRANSPORTING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_COMPLEX.html Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 9/21 Gene Ontology CC GO:0090533 0.000179172631796805 0.00032363056618298 395 318.909090909091 274 1.79187079710717e-05 210 1.78427985147075 0.970817201028414 1 5.22985708961013 395 240 439 217 312 454 235 241 274 210 491 258 M17371 GO_INTRACELLULAR_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_VESICLE.html Any vesicle that is part of the intracellular region. 696/1799 Gene Ontology CC GO:0097708 3.12535876752591e-08 2.34604852938958e-07 290 257.545454545455 275 3.12535881148131e-09 26 1.65569831771502 -1.34604163663084 -1 9.21892630737085 286 26 494 158 50 510 285 275 191 33 525 259 M17439 GO_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a coated vesicle. 89/202 Gene Ontology CC GO:0030662 2.48719068829643e-06 6.2504183384145e-06 225 330.272727272727 275 2.2610850001568e-07 107 1.4725450809372 -1.35452805034722 -1 6.43607509505979 498 221 193 107 225 328 548 556 275 217 465 260 M17532 GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 65/154 Gene Ontology CC GO:0044798 3.33934167221387e-06 7.91161318562493e-06 275 340.272727272727 275 3.0357697645029e-07 218 1.25642046593743 -0.822661994183992 -1 5.38344757117018 525 334 275 499 239 218 492 219 247 275 420 261 M17505 GO_SECRETORY_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_MEMBRANE.html The lipid bilayer surrounding a secretory granule. 44/123 Gene Ontology CC GO:0030667 0.000288843873961905 0.000507452155471066 125 249.090909090909 277 2.6261982183402e-05 102 1.46951768106541 1.71303467619417 1 4.06617138482806 206 121 102 205 318 404 277 305 277 123 402 262 M17634 GO_IKAPPAB_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IKAPPAB_KINASE_COMPLEX.html A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 6/12 Gene Ontology CC GO:0008385 5.04427979412748e-06 1.1213822003868e-05 530 329.181818181818 277 5.04429124430544e-07 144 1.19984617421892 -1.06067755440446 -1 4.98838493599796 526 158 547 176 257 411 480 418 144 227 277 263 M17438 GO_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the Golgi apparatus. 415/943 Gene Ontology CC GO:0000139 9.66575559951635e-08 4.65567228043371e-07 265 337.818181818182 278 8.78705093107617e-09 100 1.37426769130272 -1.14271273179999 -1 7.30837964658234 574 176 239 383 100 264 503 534 262 278 403 264 M17626 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT.html A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. 77/169 Gene Ontology CC GO:0005793 1.90238545811043e-05 3.89921558435401e-05 225 295.545454545455 278 1.72945628057248e-06 108 2.02136327945746 2.52131112639575 1 7.48504413463883 383 301 108 193 278 462 396 223 241 223 443 265 M17090 GO_MHC_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. 19/50 Gene Ontology CC GO:0042611 0.0425798884754112 0.0548133085496385 180 298.636363636364 279 0.00394791331376364 177 1.33926354617044 -1.10785150530836 -1 1.41849361131065 177 391 206 331 402 227 279 340 428 262 242 266 M17306 GO_PLATELET_DENSE_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_TUBULAR_NETWORK.html A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. 8/14 Gene Ontology CC GO:0031094 0.00474045832467656 0.00702560233759757 355 292.181818181818 279 0.00047506011650007 111 1.69474727726692 1.35503436565262 1 3.06492768226086 148 349 485 266 358 279 111 354 353 253 258 267 M17097 GO_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_PIT.html A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. 42/85 Gene Ontology CC GO:0005905 5.64619971889879e-07 1.78333521176148e-06 280 300.181818181818 280 5.13291015270066e-08 176 1.29252462517352 1.17332306923142 1 6.24052542430713 280 299 238 294 176 436 241 396 261 258 423 268 M17350 GO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON.html Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. 951/2385 Gene Ontology CC GO:0005856 2.47749749851936e-08 2.189755032051e-07 230 315.545454545455 280 2.47749752614033e-09 36 1.53183828379751 1.88794164059034 1 8.56779424045386 230 435 491 549 36 503 225 151 218 353 280 269 M17442 GO_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COMPLEX.html A protein complex which is capable of ATPase activity. 15/33 Gene Ontology CC GO:1904949 4.24403132254962e-05 8.20418095128321e-05 410 289.727272727273 282 3.85828472417046e-06 145 2.05496648879475 1.7816778888494 1 7.05191397537498 407 282 145 147 291 555 329 256 158 192 425 270 M17389 GO_ENDOCYTIC_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_LUMEN.html The volume enclosed by the membrane of an endocytic vesicle. 12/38 Gene Ontology CC GO:0071682 3.0717619916439e-06 7.36713041979325e-06 205 324.909090909091 283 2.79251480056064e-07 114 3.15452668229137 -2.41086292074595 -1 13.5984042576989 445 283 114 182 237 577 345 548 204 202 437 271 M17235 GO_GOLGI_CISTERNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA.html Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. 61/145 Gene Ontology CC GO:0031985 2.74370188500453e-05 5.455901287385e-05 285 285.909090909091 284 2.49430554848128e-06 135 1.16228388837972 -1.03838482634612 -1 4.1614883255169 326 215 245 335 284 135 394 281 374 376 180 272 M17087 GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX.html The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. 8/15 Gene Ontology CC GO:0008540 0.00506364491703771 0.00748538813822966 210 290.181818181818 286 0.000507522028114987 157 0.831260861629526 -0.831260861629526 -1 1.48410230780162 209 286 447 326 413 215 262 157 331 340 206 273 M17383 GO_ESCRT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_COMPLEX.html An endosomal sorting complex required for transport. 20/28 Gene Ontology CC GO:0036452 0.000967098415879374 0.00157459967430501 145 289.818181818182 286 8.79567095157537e-05 85 0.869955150656721 -0.607528786162867 -1 2.04786272713769 252 375 286 481 463 85 123 142 507 333 141 274 M17451 GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. 37/89 Gene Ontology CC GO:0012507 0.000788180539251371 0.00130162386196369 250 290.454545454545 286 7.16784597803078e-05 221 1.38614557334457 -1.45659965271135 -1 3.35922866554021 246 250 221 235 332 244 330 410 352 286 289 275 M17135 GO_CELL_PROJECTION_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_CYTOPLASM.html All of the contents of a cell projection, excluding the plasma membrane surrounding the projection. 35/73 Gene Ontology CC GO:0032838 6.18073441594705e-08 3.50241616903666e-07 385 268.272727272727 287 5.61884962690012e-09 79 1.12910575559614 -0.942717765631552 -1 6.12182658505571 384 305 270 292 79 204 287 208 366 240 316 276 M17223 GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the rough endoplasmic reticulum. 15/30 Gene Ontology CC GO:0030867 0.00286256502359558 0.00441216688970199 415 268.545454545455 287 0.000260572408617047 127 1.42069690084577 -1.00615116631113 -1 2.81037275132009 306 411 231 312 415 127 140 145 232 348 287 277 M17498 GO_PRP19_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRP19_COMPLEX.html A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. 12/20 Gene Ontology CC GO:0000974 4.23403040790427e-05 8.20418095128321e-05 290 304.272727272727 287 3.84919263320442e-06 160 1.15844601721309 -1.15844601721309 -1 3.97537347919287 287 462 309 259 290 183 244 278 480 395 160 278 M17649 GO_CHROMATOID_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATOID_BODY.html A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). 5/15 Gene Ontology CC GO:0033391 0.000169482502258399 0.000309024877934872 195 287 289 1.69495429589384e-05 73 1.76382575281827 1.76382575281827 1 5.19961505842983 192 450 548 386 425 304 224 92 73 289 174 279 M17404 GO_PROTEASOME_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_CORE_COMPLEX.html A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. 11/22 Gene Ontology CC GO:0005839 0.0295657841892008 0.0385756732762032 290 314.363636363636 290 0.00272461443512469 160 0.414717956340859 -0.414717956340859 -1 0.492392482236994 180 288 378 302 412 198 160 290 454 529 267 280 M17838 GO_CHYLOMICRON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHYLOMICRON.html A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. 5/15 Gene Ontology CC GO:0042627 0.000195811557891859 0.000351487827520168 295 286.909090909091 290 1.95828814006688e-05 95 2.46669224157925 2.82300380464947 1 7.15576759796687 291 220 577 247 314 433 352 185 95 152 290 281 M17578 GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). 22/36 Gene Ontology CC GO:0000315 0.0139525971581289 0.0192472581322161 100 297.909090909091 291 0.0012765345021957 98 0.564199319788497 -0.564199319788497 -1 0.812948185687945 98 291 389 330 372 169 175 221 450 556 226 282 M17369 GO_PLATELET_DENSE_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet dense granule. 7/15 Gene Ontology CC GO:0031089 5.07889684135332e-05 9.78534124767406e-05 295 315.818181818182 295 5.07901292345633e-06 118 2.55604501750352 2.0614810051361 1 8.60712599401683 295 289 493 324 293 333 203 481 118 133 512 283 M17586 GO_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MEMBRANE.html The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. 121/257 Gene Ontology CC GO:0019867 3.50389894979478e-06 8.26634119584237e-06 300 311.636363636364 296 3.18536775491063e-07 118 1.36367260660421 1.65142201115817 1 5.82118047612191 296 118 247 334 241 511 292 473 202 330 384 284 M17771 GO_RECYCLING_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME.html An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. 72/172 Gene Ontology CC GO:0055037 5.26666998286696e-07 1.69118625005395e-06 515 305.090909090909 296 4.78788294879732e-08 165 1.30331380757392 -1.24360189259985 -1 6.31783878151981 514 165 184 385 172 249 571 314 303 203 296 285 M17833 GO_ORGANELLE_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_SUBCOMPARTMENT.html A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. 187/420 Gene Ontology CC GO:0031984 7.78026661491067e-08 4.02549439397077e-07 340 270.454545454545 296 7.07296990005331e-09 89 1.18417679119736 -1.13984642214379 -1 6.36029115266164 340 117 283 371 89 146 490 296 311 329 203 286 M16980 GO_AGGRESOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGGRESOME.html An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. 20/47 Gene Ontology CC GO:0016235 0.0839184282471183 0.0956703185933617 180 300.636363636364 297 0.00793650793650794 179 1.3827627487018 -0.830014114384784 -1 1.18365088455489 343 244 179 297 440 252 327 459 179 272 315 287 M17821 GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX.html A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. 6/13 Gene Ontology CC GO:0036513 9.35862450698075e-05 0.000175626135228405 165 309.545454545455 297 9.35901865767976e-06 79 0.753922148773347 -0.753922148773347 -1 2.37788738281176 164 297 575 364 516 92 129 79 510 576 103 288 M17348 GO_CYTOSKELETAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PART.html Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. 685/1737 Gene Ontology CC GO:0044430 3.17292042681396e-08 2.35121539320316e-07 270 331.181818181818 298 3.17292047211736e-09 52 1.56424521208483 -1.16989801551591 -1 8.70846018590733 269 426 490 530 52 483 260 206 236 298 393 289 M17353 GO_COPI_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE.html A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. 17/32 Gene Ontology CC GO:0030137 2.77997613615256e-06 6.77985741222017e-06 300 299.272727272727 298 2.52725422637051e-07 174 1.19163702706627 -1.1258501715272 -1 5.17296541189838 421 266 298 179 233 254 368 469 174 299 331 290 M17549 GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX.html A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. 12/20 Gene Ontology CC GO:0005942 2.43310349870721e-05 4.93450463948339e-05 240 303.181818181818 298 2.21193673471026e-06 189 1.32968175016709 -1.32968175016709 -1 4.80956266531781 374 189 236 298 280 360 447 237 347 303 264 291 M16982 GO_RNA_CAP_BINDING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING_COMPLEX.html Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. 10/20 Gene Ontology CC GO:0034518 7.92816626609123e-05 0.000150245249239368 355 285.909090909091 299 7.20768362616444e-06 164 1.22644988153695 -0.60141729070737 -1 3.93807744872608 351 269 225 372 299 211 189 319 164 369 377 292 M17131 GO_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INCLUSION_BODY.html A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. 43/96 Gene Ontology CC GO:0016234 0.0839184282471183 0.0956703185933617 300 360.181818181818 299 0.00793650793650794 226 1.3705634085409 -0.792039351569786 -1 1.17320817328805 543 274 226 299 429 293 509 258 299 295 537 293 M17463 GO_BLOC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_COMPLEX.html Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. 8/21 Gene Ontology CC GO:0031082 0.000844970383267006 0.00139143271090692 235 301.545454545455 300 8.45291844036264e-05 113 0.864757286177935 -0.864757286177935 -1 2.07463383305359 235 308 508 300 546 113 130 121 402 536 118 294 M17597 GO_INHIBITORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INHIBITORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. 6/20 Gene Ontology CC GO:0060077 0.00791191407742334 0.0112637594501248 215 298.909090909091 300 0.000794022531790636 117 0.834412992399079 0.834412992399079 1 1.36536120742179 213 205 541 249 405 261 117 362 329 306 300 295 M17219 GO_SNARE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_COMPLEX.html A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. 28/55 Gene Ontology CC GO:0031201 8.63446156225594e-05 0.00016256412973889 370 307.272727272727 302 7.84981860214676e-06 177 1.04991361921042 -1.16552839068903 -1 3.34104867946289 284 393 361 369 300 200 302 177 370 425 199 296 M17510 GO_POLE_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLE_PLASM.html Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. 8/18 Gene Ontology CC GO:0045495 9.41642036688349e-05 0.000176138866409665 305 300.272727272727 302 9.41681940105739e-06 54 2.47339099420692 2.98795213403992 1 7.79850679464768 256 321 523 304 302 452 398 229 54 199 265 297 M17643 GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX.html Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. 67/172 Gene Ontology CC GO:0031461 3.95921010248674e-07 1.33047874374264e-06 400 298.181818181818 302 3.59928255909326e-08 139 1.40301973840474 -0.865297067399723 -1 6.92392926156416 400 361 249 410 162 143 343 487 139 284 302 298 M17112 GO_BLOC_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_1_COMPLEX.html A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. 4/16 Gene Ontology CC GO:0031083 0.00472350526332133 0.00701847311619468 360 325.272727272727 303 0.000473357557816966 154 0.929169266585641 -0.929169266585641 -1 1.68073302214622 358 303 451 189 495 270 412 154 223 504 219 299 M17017 GO_PHOSPHATASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_COMPLEX.html A protein complex which is capable of phosphatase activity. 21/58 Gene Ontology CC GO:1903293 4.2177664783237e-06 9.71262559550239e-06 160 244.545454545455 304 3.83434051318759e-07 22 1.20773141920936 1.50012400868564 1 5.08447930643486 159 410 304 314 340 159 58 401 122 401 22 300 M17795 GO_HISTONE_DEACETYLASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_COMPLEX.html A protein complex that possesses histone deacetylase activity. 32/70 Gene Ontology CC GO:0000118 0.00011642476707588 0.000216377862925591 425 326 306 1.0584629888333e-05 196 1.0015919423095 -0.835265287518459 -1 3.08281181284026 424 196 306 498 304 207 425 318 401 290 217 301 M17080 GO_CYTOPLASMIC_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SIDE_OF_MEMBRANE.html The side of a membrane that faces the cytoplasm. 89/232 Gene Ontology CC GO:0098562 7.44161791133053e-08 3.93912981057032e-07 310 258 307 6.76510742095206e-09 72 1.62804959346417 -1.24571877172507 -1 8.75724091024713 308 213 100 311 87 538 307 316 260 72 326 302 M17418 GO_CELL_TRAILING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_TRAILING_EDGE.html The area of a motile cell opposite to the direction of movement. 7/27 Gene Ontology CC GO:0031254 0.00167387896744429 0.00263624534927193 310 287.272727272727 307 0.000167514114757535 70 3.12840148264407 3.12840148264407 1 6.77616307793093 199 434 502 258 456 307 174 129 70 323 308 303 M17055 GO_ZYMOGEN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_GRANULE.html A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. 7/28 Gene Ontology CC GO:0042588 7.3832693667551e-07 2.23430874030599e-06 540 343.636363636364 308 7.38327181982624e-08 139 1.04027095426074 -1.22730265605864 -1 4.93705936915229 539 175 442 241 187 504 561 139 308 235 449 304 M17543 GO_NADH_DEHYDROGENASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX.html An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. 31/51 Gene Ontology CC GO:0030964 0.000600819985930509 0.00100368194181455 85 262.545454545455 308 5.4634921148009e-05 65 0.691138775649038 -0.691138775649038 -1 1.74045395179453 81 330 394 308 368 72 65 204 493 451 122 305 M17522 GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK.html The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. 537/1316 Gene Ontology CC GO:0042175 4.31381091767568e-08 2.81975129671207e-07 425 272.636363636364 309 4.31381100141602e-09 55 1.40782008868867 -1.17857320844844 -1 7.74429947837115 425 63 527 309 70 55 417 378 205 316 234 306 M17566 GO_GAMMA_TUBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_COMPLEX.html A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. 7/25 Gene Ontology CC GO:0000930 0.0765897756730953 0.0933942834157154 420 326.363636363636 310 0.00793650793650794 48 2.63247788215387 2.63247788215387 1 2.27653423412853 288 341 536 230 416 464 418 310 48 238 301 307 M17637 GO_LYTIC_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE.html A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. 310/770 Gene Ontology CC GO:0000323 2.84869524002069e-08 2.22506195774589e-07 565 318.909090909091 310 2.58972297900668e-09 39 1.48511564420864 -1.22509414505095 -1 8.29780323614929 565 90 136 310 39 358 567 578 257 126 482 308 M17710 GO_MICROTUBULE_ORGANIZING_CENTER_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_PART.html Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. 74/194 Gene Ontology CC GO:0044450 2.75626847044363e-05 5.455901287385e-05 315 335.363636363636 310 2.50573000267245e-06 168 1.14755497631396 -1.04995712298887 -1 4.10875229837642 315 483 310 503 286 168 295 300 395 387 247 309 M16999 GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX.html A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. 14/29 Gene Ontology CC GO:0005669 2.04020058569706e-06 5.33590922413077e-06 520 309.909090909091 311 1.85472952518899e-07 18 1.66737449550291 -0.641882744144984 -1 7.38382524642665 520 311 192 216 214 430 461 136 18 334 577 310 M17323 GO_MICROVILLUS_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_MEMBRANE.html The portion of the plasma membrane surrounding a microvillus. 13/30 Gene Ontology CC GO:0031528 4.3208627199612e-06 9.83251437849438e-06 315 307.272727272727 311 3.92806473298373e-07 150 1.80478377417818 1.63049296089613 1 7.58996051355567 311 331 150 207 247 427 242 441 348 176 500 311 M17288 GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex that possesses activity that prevents or downregulates transcription. 35/99 Gene Ontology CC GO:0017053 2.51197335866759e-06 6.25827845392183e-06 370 332.909090909091 312 2.28361475168964e-07 212 1.22812779170224 -1.22619419516267 -1 5.36723333907618 367 432 312 561 227 212 404 240 379 310 218 312 M17099 GO_RNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_COMPLEX.html Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. 63/133 Gene Ontology CC GO:0030880 7.53883070080424e-06 1.63200155245875e-05 280 346.363636363636 313 6.85350594050013e-07 225 0.997942799016473 -0.752755835506567 -1 4.01237898336117 276 467 393 502 261 225 290 383 242 458 313 313 M17329 GO_ARP2_3_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_PROTEIN_COMPLEX.html A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. 6/11 Gene Ontology CC GO:0005885 0.000180255144627383 0.000324571568830615 535 346.818181818182 313 1.80269767659523e-05 161 0.974110841649132 -0.789261349729916 -1 2.85415859813745 532 185 487 222 313 567 314 161 198 305 531 314 M17285 GO_STEREOCILIUM_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEREOCILIUM_BUNDLE.html A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. 19/77 Gene Ontology CC GO:0032421 0.0200123578674377 0.0268951806429303 315 313.363636363636 314 0.0018360684934374 191 1.54828539458861 -1.71388068902062 -1 2.04196339669269 417 357 201 301 442 248 322 191 314 313 341 315 M17585 GO_GOLGI_TRANSPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TRANSPORT_COMPLEX.html A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). 3/12 Gene Ontology CC GO:0017119 0.000144886423118801 0.000265940360928426 315 326.272727272727 314 1.44895870419731e-05 85 0.472453297113837 -0.472453297113837 -1 1.4186267144523 314 246 539 336 574 214 133 85 397 558 193 316 M17146 GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX.html A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. 7/13 Gene Ontology CC GO:0043240 0.0557899818291578 0.0710277742230247 380 332.090909090909 317 0.00572421993268345 222 0.959818632281214 -0.959818632281214 -1 0.925878259424768 222 377 456 377 398 242 258 246 467 317 293 317 M17315 GO_MYELIN_SHEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_SHEATH.html An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. 124/303 Gene Ontology CC GO:0043209 2.97561301239246e-06 7.19625238980267e-06 345 303.363636363636 317 2.70510639733594e-07 159 1.81143891626924 2.30273829790582 1 7.82418110549195 345 317 173 196 235 484 344 329 159 296 459 318 M17503 GO_SPERM_MIDPIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MIDPIECE.html The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. 8/16 Gene Ontology CC GO:0097225 0.000515912243559427 0.000874478817528882 175 294.181818181818 317 5.16032057159078e-05 48 0.940349380098868 0.940349380098868 1 2.41529208244258 171 424 522 317 383 217 48 174 482 342 156 319 M17593 GO_CIS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. 28/52 Gene Ontology CC GO:0005801 4.66842354355927e-07 1.54191360467272e-06 285 342.363636363636 317 4.24402230382184e-08 167 1.14352975195538 -0.845995567797294 -1 5.58182464211501 549 281 285 228 167 317 507 391 170 350 521 320 M16996 GO_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_COMPLEX.html A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. 47/87 Gene Ontology CC GO:0000502 0.000413487227256495 0.000711296480220995 70 269.818181818182 318 3.75968147377027e-05 65 0.685025143642605 -0.711417621812359 -1 1.81109577917961 66 318 404 412 458 65 99 138 443 461 104 321 M17067 GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 143/347 Gene Ontology CC GO:0031300 0.000260139178522037 0.000461228359465452 395 289.363636363636 319 2.36518130721282e-05 56 1.25946019731088 -0.952182935431951 -1 3.52881511471702 394 187 319 370 321 56 297 372 278 362 227 322 M17290 GO_INVADOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_INVADOPODIUM.html A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. 7/17 Gene Ontology CC GO:0071437 0.00667874375829675 0.00955523240667208 165 311.454545454545 320 0.000669890160395475 108 1.47295772005894 1.47295772005894 1 2.49860223780595 163 383 484 347 519 237 108 216 455 320 194 323 M17575 GO_AUTOPHAGOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_MEMBRANE.html The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. 19/34 Gene Ontology CC GO:0000421 1.14954006479704e-05 2.39867926878227e-05 265 346.545454545455 320 1.04504188308833e-06 245 1.07868344337278 -1.14935195138323 -1 4.1854883321462 502 265 255 320 271 414 517 381 245 263 379 324 M17675 GO_A_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_A_BAND.html The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. 18/72 Gene Ontology CC GO:0031672 0.000372434875536299 0.000646448522702645 435 341.090909090909 320 3.38634490413046e-05 135 2.04526916054552 -1.86107906682488 -1 5.47868146778141 431 302 135 284 320 574 363 466 193 151 533 325 M17467 GO_CATALYTIC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_COMPLEX.html A protein complex which is capable of catalytic activity. 557/1220 Gene Ontology CC GO:1902494 0.000635246000260894 0.00105813310706281 510 347.636363636364 321 6.35427665219426e-05 78 1.23962248154981 -0.953510221651961 -1 3.09778271057055 300 509 510 572 356 78 271 321 285 477 145 326 M17502 GO_STAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAGA_COMPLEX.html A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. 6/17 Gene Ontology CC GO:0030914 0.0019022805621025 0.00297972402410635 325 357.454545454545 321 0.000190391092877638 249 0.751165001316394 -0.751165001316394 -1 1.59347592936008 321 359 521 321 343 269 267 297 441 544 249 327 M17729 GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. 13/29 Gene Ontology CC GO:0031233 1.06078824599295e-06 2.97903456574831e-06 410 306.090909090909 321 9.64353415891302e-08 61 1.91398579004084 -2.25306499099739 -1 8.88282958739752 408 61 91 277 199 485 375 513 321 131 506 328 M17113 GO_T_CELL_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_COMPLEX.html A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. 6/24 Gene Ontology CC GO:0042101 0.000380517528306357 0.000658500393296631 560 328 322 3.80582701128399e-05 131 2.22470036522948 -2.35313255751147 -1 5.94433692999847 558 184 452 213 322 530 430 131 200 170 418 329 M17529 GO_SEMAPHORIN_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_COMPLEX.html A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. 3/11 Gene Ontology CC GO:0002116 0.0765897756730953 0.0933942834157154 220 327 323 0.00793650793650794 202 1.23382271260051 1.23382271260051 1 1.06699317503316 220 327 530 280 421 323 202 309 372 246 367 330 M17464 GO_BETA_CATENIN_DESTRUCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX.html A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. 7/18 Gene Ontology CC GO:0030877 0.0187336425977174 0.0254179469987809 285 343.181818181818 324 0.00188934693882613 139 1.55112493926463 1.55112493926463 1 2.07766953340498 282 454 509 389 428 314 139 231 413 324 292 331 M17251 GO_COMPACT_MYELIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPACT_MYELIN.html The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. 10/26 Gene Ontology CC GO:0043218 0.000500937953266704 0.000851594520553397 445 327.090909090909 326 4.55501866133422e-05 73 1.2065057946974 -1.61185650772712 -1 3.11058649652847 564 73 177 169 326 542 444 400 181 280 442 332 M17663 GO_INTERCELLULAR_BRIDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCELLULAR_BRIDGE.html A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. 31/52 Gene Ontology CC GO:0045171 1.22929394519055e-06 3.39967416421119e-06 190 269.090909090909 327 1.11754057462149e-07 11 1.00503997563112 -0.903562482594849 -1 4.61598182766602 190 385 327 551 389 27 190 93 424 373 11 333 M17100 GO_MRNA_CLEAVAGE_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_FACTOR_COMPLEX.html Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. 13/20 Gene Ontology CC GO:0005849 0.125832024943647 0.142052559409039 360 379 328 0.0121512725118987 211 1.04137472330859 -1.06616647297223 -1 0.741274556537913 359 507 308 534 557 302 211 273 479 311 328 334 M17388 GO_U5_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U5_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U5. 6/20 Gene Ontology CC GO:0005682 0.00516417662904437 0.00760153740991035 330 356.090909090909 328 0.000517621695147481 158 0.679165243391042 -0.679165243391042 -1 1.20874158554301 328 442 496 328 570 232 214 158 452 528 169 335 M17698 GO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS.html A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. 783/1929 Gene Ontology CC GO:0005794 5.59616241974283e-08 3.23458187861135e-07 80 281.636363636364 328 5.59616256066947e-09 62 1.54718970435388 -1.20067657935016 -1 8.43350493208503 344 62 556 332 78 402 328 184 207 79 526 336 M17716 GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE.html A clathrin coat found on an endocytic vesicle. 9/17 Gene Ontology CC GO:0030128 0.000578561707760916 0.000972118218272702 290 349.545454545455 328 5.78712393120698e-05 252 1.04977087779146 1.04977087779146 1 2.65581222027877 290 285 560 252 328 418 386 307 368 360 291 337 M17209 GO_NPBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NPBAF_COMPLEX.html A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. 9/15 Gene Ontology CC GO:0071564 0.0432079778033125 0.0554982470451436 300 336.272727272727 329 0.00440718312242065 181 0.93591427977002 0.867958395243975 1 0.98704233232137 297 329 469 244 394 363 181 478 357 266 321 338 M17277 GO_PARANODE_REGION_OF_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARANODE_REGION_OF_AXON.html An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. 6/35 Gene Ontology CC GO:0033270 0.00065840003748795 0.00109354948755183 365 304.818181818182 330 6.58595189642929e-05 72 0.950826164602399 -1.00582517727746 -1 2.36467002966002 361 152 482 72 330 441 321 366 172 226 430 339 M17832 GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the nucleus. 24/47 Gene Ontology CC GO:0000152 0.000303091325531081 0.0005308690489605 105 319.272727272727 330 2.75575536463782e-05 103 0.801931325726759 -0.801931325726759 -1 2.20575584222473 160 460 330 535 565 104 141 103 513 434 167 340 M17048 GO_OXIDOREDUCTASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_COMPLEX.html Any protein complex that possesses oxidoreductase activity. 56/106 Gene Ontology CC GO:1990204 0.000550559898130928 0.000927765659241038 90 268.454545454545 331 5.00634296830861e-05 71 0.942953904906665 -0.828413222558161 -1 2.4016373980344 86 373 382 456 331 71 80 212 447 409 106 341 M17354 GO_NUCLEAR_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EUCHROMATIN.html The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. 20/47 Gene Ontology CC GO:0005719 0.068156208482015 0.0857702619190539 335 339.636363636364 331 0.00639673359598064 187 1.71493718476287 1.9594900915017 1 1.53632328469692 333 414 187 342 524 517 264 244 295 331 285 342 M17630 GO_INTEGRATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRATOR_COMPLEX.html A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. 9/14 Gene Ontology CC GO:0032039 0.000941612698362472 0.00153743542275003 365 333.363636363636 332 9.42011921975086e-05 124 0.748278055497542 -0.797623095349761 -1 1.76795519564462 364 198 546 248 336 308 332 124 355 561 295 343 M17239 GO_GOLGI_APPARATUS_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS_PART.html Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. 496/1202 Gene Ontology CC GO:0044431 7.43705609116101e-08 3.93912981057032e-07 440 299 333 6.76096031142656e-09 86 1.49146588807555 -1.23741355970317 -1 8.02256011204682 437 135 155 333 86 369 426 445 221 168 514 344 M17638 GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. 12/29 Gene Ontology CC GO:0080008 0.000367809771862805 0.000640343518484041 125 259.727272727273 333 3.34428435454382e-05 49 0.696796667613303 -0.696796667613303 -1 1.86892556735325 124 343 333 388 470 63 49 152 430 397 108 345 M17748 GO_MITOCHONDRIAL_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PROTEIN_COMPLEX.html A protein complex that is part of a mitochondrion. 75/156 Gene Ontology CC GO:0098798 0.000930754321587444 0.00152401132543213 65 309.363636363636 333 8.46498481221977e-05 65 0.556930756274577 -0.556930756274577 -1 1.31764009721241 65 427 415 453 333 132 162 252 496 476 192 346 M17168 GO_LUMENAL_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUMENAL_SIDE_OF_MEMBRANE.html Any side (leaflet) of a membrane that faces the lumen of an organelle. 26/66 Gene Ontology CC GO:0098576 0.0812984442852866 0.0956703185933617 295 344.454545454545 335 0.00767890705350285 199 1.36436374746702 -0.958089141925048 -1 1.1679012247406 292 409 199 246 404 245 306 546 417 335 390 347 M17800 GO_SITE_OF_DOUBLE_STRAND_BREAK http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_DOUBLE_STRAND_BREAK.html A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. 22/46 Gene Ontology CC GO:0035861 0.0743472427784469 0.093014515857018 270 348.818181818182 336 0.00699867683184096 215 0.799759593073906 -0.799759593073906 -1 0.692808927765895 215 390 336 482 410 258 305 267 499 405 270 348 M17806 GO_GOLGI_CISTERNA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA_MEMBRANE.html The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. 38/86 Gene Ontology CC GO:0032580 9.92757956242373e-07 2.86470181848932e-06 570 348 336 9.02507640207521e-08 109 1.13860456191849 -1.05719452035198 -1 5.30052839420795 567 109 216 319 192 349 551 380 333 336 476 349 M17149 GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX.html A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. 10/15 Gene Ontology CC GO:0005847 0.0302263719849657 0.0393487455119598 295 383.636363636364 337 0.00278634798841347 211 1.06616647297223 -1.06616647297223 -1 1.25814182168083 294 546 292 559 488 337 283 211 516 370 324 350 M17582 GO_RECYCLING_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a recycling endosome. 18/51 Gene Ontology CC GO:0055038 0.0839184282471183 0.0956703185933617 510 375.272727272727 337 0.00793650793650794 191 1.49949506558042 -1.7659148106764 -1 1.28357447587987 507 319 191 337 518 377 533 327 315 259 445 351 M16976 GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. 82/187 Gene Ontology CC GO:0000784 0.00595818904113427 0.00865284740144624 60 299.181818181818 338 0.000543126078268693 58 1.20513191790231 -1.21856592703379 -1 2.08788988238839 58 407 338 473 381 188 237 160 411 416 222 352 M17051 GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the cytoplasm. 8/16 Gene Ontology CC GO:0000153 0.00116438377033582 0.00186430420846013 130 302.909090909091 338 0.000116499432593798 111 0.920179977956952 -0.920179977956952 -1 2.10940741991798 208 395 441 428 473 111 178 127 506 338 127 353 M17610 GO_PHOTORECEPTOR_INNER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_INNER_SEGMENT.html The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. 21/55 Gene Ontology CC GO:0001917 0.0017023525212896 0.00267380368832986 345 336.545454545455 340 0.000154879202243303 182 1.40243592003539 -0.987571839963541 -1 3.03045876037072 500 230 182 325 341 516 220 341 340 206 501 354 M16986 GO_ENDOLYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME.html An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. 25/66 Gene Ontology CC GO:0036019 6.89152894102519e-07 2.11877857867689e-06 455 369.090909090909 341 6.26502827255149e-08 165 1.71023916868906 1.31599198214008 1 8.14980647711212 451 257 165 341 181 551 463 568 318 205 560 355 M17590 GO_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SUBUNIT.html Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. 109/272 Gene Ontology CC GO:0044391 0.00203205760567538 0.00317440350291991 170 328.545454545455 342 0.000184903361080989 129 0.563118339165284 -0.560456129123914 -1 1.18156515479241 169 457 423 418 342 129 196 249 481 559 191 356 M17689 GO_DENDRITE_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_CYTOPLASM.html All of the contents of a dendrite, excluding the surrounding plasma membrane. 13/26 Gene Ontology CC GO:0032839 2.34568060241252e-06 5.94650608857208e-06 210 318.181818181818 342 2.13243918493109e-07 209 1.24135142041346 -1.12974063604987 -1 5.44816164467123 477 342 209 269 223 346 448 235 354 209 388 357 M17178 GO_PRECATALYTIC_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRECATALYTIC_SPLICEOSOME.html A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. 13/27 Gene Ontology CC GO:0071011 0.0839184282471183 0.0956703185933617 190 354.636363636364 343 0.00793650793650794 188 0.813769328904301 -0.813769328904301 -1 0.696588968311355 188 417 348 343 438 276 325 332 445 508 281 358 M17539 GO_DNA_HELICASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_COMPLEX.html A protein complex that possesses DNA helicase activity. 12/18 Gene Ontology CC GO:0033202 0.159220188414395 0.179045270240312 260 393.818181818182 344 0.0156423198378058 257 0.410223223927794 -0.410223223927794 -1 0.257374652056993 257 545 344 514 436 280 269 286 527 547 327 359 M17452 GO_SPINDLE_MIDZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MIDZONE.html The area in the center of the spindle where the spindle microtubules from opposite poles overlap. 10/32 Gene Ontology CC GO:0051233 0.00414928980020731 0.0061971305026352 205 322.272727272727 345 0.000377921477836398 93 1.22716820304647 1.22716820304647 1 2.27547969665245 203 440 240 431 395 294 93 345 523 371 210 360 M17039 GO_CYTOPLASMIC_STRESS_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_STRESS_GRANULE.html A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. 15/44 Gene Ontology CC GO:0010494 0.000213631063967279 0.000382287167099342 350 312.090909090909 346 1.94228919489609e-05 98 1.68973706209293 -1.68973706209293 -1 4.85008374117124 346 461 242 500 409 226 291 98 350 347 163 361 M17422 GO_MLL1_2_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MLL1_2_COMPLEX.html A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. 14/35 Gene Ontology CC GO:0044665 0.041898502375541 0.0540565499398722 250 351.909090909091 347 0.00388349050778025 216 0.476471971758273 -0.476471971758273 -1 0.507074179058989 238 404 347 368 497 216 250 245 525 531 250 362 M17762 GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 78/190 Gene Ontology CC GO:0019897 1.94171992430721e-07 7.48209410833043e-07 350 325.272727272727 348 1.76520008698493e-08 95 1.63914953756249 1.94482805344769 1 8.43337857901419 348 271 107 384 137 561 360 531 291 95 493 363 M17064 GO_DNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_COMPLEX.html A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. 8/13 Gene Ontology CC GO:0042575 0.00868333779504954 0.0123013952096535 455 377.909090909091 349 0.000871745573476331 171 1.4810923444139 -1.4810923444139 -1 2.37592759587588 349 453 443 491 569 332 304 171 453 339 253 364 M17714 GO_CYTOPLASMIC_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE.html Any microtubule in the cytoplasm of a cell. 37/84 Gene Ontology CC GO:0005881 0.0200550568461989 0.0268951806429303 280 350.818181818182 349 0.00184002229326116 179 1.74875449151422 2.20931024152206 1 2.30635334142224 279 570 207 511 378 449 179 291 349 287 359 365 M17828 GO_MHC_CLASS_I_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_COMPLEX.html A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. 15/39 Gene Ontology CC GO:0042612 0.0839184282471183 0.0956703185933617 350 357.454545454545 349 0.00793650793650794 252 1.31998269315602 -0.927869007381074 -1 1.12991076543913 258 430 252 323 418 287 359 472 437 349 347 366 M17780 GO_PROTEASOME_ACCESSORY_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ACCESSORY_COMPLEX.html A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. 17/28 Gene Ontology CC GO:0022624 0.0549520939247866 0.0701154752506107 350 352.909090909091 350 0.00512497305665558 219 0.716074644791278 -0.80301445458771 -1 0.694129161793987 219 350 367 423 542 233 349 261 464 420 254 367 M17732 GO_SPERM_FLAGELLUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_FLAGELLUM.html A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. 28/88 Gene Ontology CC GO:0036126 0.051202410276163 0.0656208273605814 540 371.181818181818 351 0.00476676556566381 171 1.18397415065977 1.10728587132451 1 1.17630104762069 240 539 282 539 486 368 171 335 438 351 334 368 M17718 GO_PIGMENT_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE.html A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. 70/141 Gene Ontology CC GO:0048770 2.24152453005322e-06 5.78393383201232e-06 280 345.636363636364 353 2.03775164899027e-07 185 1.48460292270392 -1.10788731474125 -1 6.53077798822427 432 366 185 353 220 480 376 287 276 276 551 369 M17724 GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX.html Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. 26/50 Gene Ontology CC GO:0008023 0.000850408650817198 0.00139640965958051 210 294.727272727273 354 7.7339777615049e-05 97 0.714226439469718 -0.789315922666835 -1 1.71256560111047 207 354 383 532 388 97 144 132 449 439 117 370 M17565 GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. 54/135 Gene Ontology CC GO:0031234 2.02484892049919e-07 7.66481093969737e-07 355 340.181818181818 355 1.84077191533041e-08 102 1.58142010130482 1.75358613109038 1 8.12244516605394 355 322 124 427 140 564 355 483 332 102 538 371 M17719 GO_EXTRINSIC_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 140/326 Gene Ontology CC GO:0019898 1.25615489526509e-07 5.34414391067974e-07 160 345.272727272727 355 1.14195906089906e-08 118 1.55829778961411 -1.36356295740946 -1 8.20866645121064 573 363 158 518 118 338 531 355 306 160 378 372 M17429 GO_NUCLEOPLASM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPLASM_PART.html Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. 414/883 Gene Ontology CC GO:0044451 0.00142999405427254 0.00227070484442177 250 359.545454545455 356 0.000130084035750746 95 1.16942812347451 -0.846933339817359 -1 2.59666517755108 248 503 422 576 532 95 240 356 320 488 175 373 M16987 GO_90S_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_90S_PRERIBOSOME.html A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 15/28 Gene Ontology CC GO:0030686 0.0101384398297387 0.0142233451980315 545 351.818181818182 358 0.000925951391614877 153 0.521441528138705 -0.521441528138705 -1 0.808869542896697 200 477 358 475 541 153 207 239 541 490 189 374 M17402 GO_PRC1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRC1_COMPLEX.html A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. 9/12 Gene Ontology CC GO:0035102 2.55653688051308e-05 5.14870493706119e-05 195 308.363636363636 358 2.556566292453e-06 38 1.23701618258931 -1.23701618258931 -1 4.45521115351258 195 470 498 544 578 38 84 94 490 358 43 375 M17018 GO_TRANSCRIPTION_EXPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_EXPORT_COMPLEX.html The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. 14/40 Gene Ontology CC GO:0000346 0.00527316457726011 0.00773575920217347 350 374.818181818182 359 0.000480531487687982 171 0.517849912371487 -0.517849912371487 -1 0.918334585228576 350 437 341 413 359 171 282 465 551 493 261 376 M17413 GO_SIN3_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_TYPE_COMPLEX.html Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. 9/22 Gene Ontology CC GO:0070822 4.03814944224452e-05 7.85875548019305e-05 95 297.272727272727 359 4.03822282405039e-06 67 0.85929508453028 -0.85929508453028 -1 2.96227571079822 363 280 500 387 559 141 91 67 431 359 92 377 M17477 GO_ENDOLYSOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME_MEMBRANE.html The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. 19/50 Gene Ontology CC GO:0036020 3.33985054894893e-06 7.91161318562493e-06 540 394.545454545455 359 3.03623238112109e-07 240 1.16234549339204 0.922329667490306 1 4.98035963544115 540 294 254 303 240 478 576 509 359 314 473 378 M17241 GO_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of a ribosome. 52/104 Gene Ontology CC GO:0015935 0.0186249154312704 0.0253298849865278 460 348.454545454545 360 0.00170768055056726 177 0.563124060328265 -0.558465669519449 -1 0.754993212603621 254 458 412 360 380 177 268 304 460 517 243 379 M17344 GO_PHAGOCYTIC_CUP http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_CUP.html An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. 18/43 Gene Ontology CC GO:0001891 0.00591177841976184 0.00860707286302858 240 355.363636363636 360 0.000538884037004635 214 1.15937572545297 -1.01546843812539 -1 2.0108602392833 236 469 214 446 360 390 234 323 511 374 352 380 M16993 GO_NUCLEAR_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE.html The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). 223/592 Gene Ontology CC GO:0005635 3.75553530189277e-07 1.26941485642925e-06 165 380.272727272727 362 3.41412358453263e-08 161 1.2442637667767 -1.13773926928704 -1 6.16178795808549 521 504 362 570 161 162 536 311 335 445 276 381 M17167 GO_PORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX.html Any small opening in a membrane that allows the passage of gases and/or liquids. 11/21 Gene Ontology CC GO:0046930 0.00471215495063482 0.00701847311619468 390 345.818181818182 364 0.00042929802098372 153 1.50122761532797 1.67576878261433 1 2.7155055974738 389 358 251 402 489 535 243 153 364 231 389 382 M17460 GO_COP9_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_COP9_SIGNALOSOME.html A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. 21/56 Gene Ontology CC GO:0008180 0.0839184282471183 0.0956703185933617 400 350.818181818182 364 0.00793650793650794 136 4.17537021481477 -2.53204610565318 -1 3.57414029345713 399 498 203 260 517 290 320 470 136 402 364 383 M17198 GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE.html The membrane surrounding the outer segment of a vertebrate photoreceptor. 6/19 Gene Ontology CC GO:0042622 8.67220747748685e-06 1.84284408896596e-05 370 344.363636363636 366 8.67224132090486e-07 171 1.92562951937081 2.14750897768451 1 7.65694555583914 366 211 463 254 267 515 445 436 185 171 475 384 M17269 GO_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME.html A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. 313/765 Gene Ontology CC GO:0000228 0.00120357301123641 0.00192172707318963 285 391.818181818182 366 0.000109475633188997 283 1.46108412194341 -1.20449111982216 -1 3.33320283310529 283 526 321 557 337 291 403 409 365 452 366 385 M17731 GO_CILIARY_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PLASM.html All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. 34/119 Gene Ontology CC GO:0097014 0.00293167376613918 0.00450666871496927 320 387.545454545455 366 0.00026687161426558 277 1.44300317588895 1.117941236333 1 2.84334410231115 317 374 277 438 347 473 366 544 288 352 487 386 M17823 GO_DENSE_CORE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENSE_CORE_GRANULE.html Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. 3/17 Gene Ontology CC GO:0031045 0.0215399410198786 0.0286208871482526 370 365.272727272727 366 0.00217516205886508 201 1.2252092021616 1.2252092021616 1 1.58808025602177 304 400 576 366 417 366 299 201 483 249 357 387 M17495 GO_RESPIRATORY_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN.html The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. 44/93 Gene Ontology CC GO:0070469 0.00349704173492739 0.00529133539996867 115 298.090909090909 367 0.000318419355459011 115 0.747596463283243 -0.646347876465056 -1 1.42931989339151 115 367 398 381 411 116 124 263 487 453 164 388 M17764 GO_BRUSH_BORDER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER_MEMBRANE.html The portion of the plasma membrane surrounding the brush border. 27/96 Gene Ontology CC GO:0031526 2.26313933772441e-06 5.81375349868761e-06 480 373.363636363636 367 2.05740151438047e-07 154 1.65762303051321 -1.44746617252447 -1 7.28878574608606 478 356 154 233 221 553 390 572 367 218 565 389 M17221 GO_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIGASE_COMPLEX.html A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. 134/305 Gene Ontology CC GO:0000151 0.000261892256936571 0.000462916588713572 285 348 368 2.38112216631235e-05 57 1.23900417239759 -0.9614117249146 -1 3.46984926346183 281 465 368 564 446 57 316 417 326 422 166 390 M17249 GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX.html A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. 4/11 Gene Ontology CC GO:0000164 0.0119349273453902 0.0165826634750854 380 353.363636363636 369 0.001199951520965 206 0.894556810183942 -0.494612970343855 -1 1.33757830318274 379 245 476 206 369 522 408 336 251 267 428 391 M17259 GO_PML_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PML_BODY.html A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. 58/135 Gene Ontology CC GO:0016605 2.00996482307987e-05 4.10515783653768e-05 470 346.454545454545 369 1.82725744251172e-06 89 1.74072832846374 -1.1306882123039 -1 6.41318256649565 467 369 195 398 279 426 459 284 89 328 517 392 M17338 GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX.html A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. 5/19 Gene Ontology CC GO:0033276 0.000599697631768511 0.00100368194181455 525 389.454545454545 369 5.99859530024523e-05 231 0.873231877006675 -0.646917822627977 -1 2.19900895128375 523 360 488 231 329 395 339 512 369 288 450 393 M17415 GO_SMALL_SUBUNIT_PROCESSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_SUBUNIT_PROCESSOME.html A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 16/36 Gene Ontology CC GO:0032040 0.0158483194628677 0.0217069399278141 265 351.818181818182 369 0.00145124110442229 174 0.539289025626655 -0.539289025626655 -1 0.753398796968128 174 412 369 458 373 230 280 262 520 530 262 394 M17760 GO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM.html A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. 237/685 Gene Ontology CC GO:0005929 9.23107393662124e-08 4.55247284839071e-07 370 357.454545454545 369 8.39188574904713e-09 96 1.2442643161329 -1.10339717853783 -1 6.6271923820821 369 200 322 419 96 421 391 536 269 346 563 395 M17134 GO_NUCLEAR_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INCLUSION_BODY.html An intranuclear focus at which aggregated proteins have been sequestered. 9/14 Gene Ontology CC GO:0042405 0.00309159681351445 0.00471488907179776 460 383.818181818182 370 0.000309590634089886 242 1.21867229839954 -0.322847914084381 -1 2.38123711912715 458 320 454 242 350 460 370 320 416 355 477 396 M17103 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX.html A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. 51/124 Gene Ontology CC GO:0090575 1.34561885489478e-05 2.78769784275692e-05 425 351 371 1.22329735034074e-06 128 1.37934801097439 1.78265679259369 1 5.27650551846053 423 371 267 480 273 399 499 128 215 282 524 397 M17528 GO_SCHMIDT_LANTERMAN_INCISURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHMIDT_LANTERMAN_INCISURE.html Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. 7/21 Gene Ontology CC GO:0043220 0.0121339350131147 0.0167785034391873 470 375.909090909091 371 0.00122007032603382 211 1.06726757187813 -1.25641217549421 -1 1.5912526159391 466 233 529 211 371 417 547 386 313 326 336 398 M17153 GO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAJAL_BODY.html A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. 28/64 Gene Ontology CC GO:0015030 0.0204490215555649 0.0272968463259041 205 319.181818181818 372 0.00187650965709345 152 0.77921663400079 -0.77921663400079 -1 1.02345891191315 152 372 377 505 386 203 223 213 433 443 204 399 M17570 GO_EXOCYST http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYST.html A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. 10/21 Gene Ontology CC GO:0000145 0.415320710913563 0.44786449796276 330 383.545454545455 372 0.0476190476190476 233 0.895086294302356 -0.938670834794546 -1 0.262247426402384 327 323 233 245 469 438 286 562 484 372 480 400 M17104 GO_INO80_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INO80_TYPE_COMPLEX.html A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. 17/26 Gene Ontology CC GO:0097346 0.0725503677391932 0.0909633677944766 275 397.545454545455 373 0.0068235938165126 239 0.410223223927794 -0.410223223927794 -1 0.35869989268122 275 572 373 507 550 239 256 289 528 502 282 401 M17208 GO_M_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_M_BAND.html The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. 9/40 Gene Ontology CC GO:0031430 0.0402505256824895 0.0521632373194595 415 375 374 0.00409987176636531 212 1.30960520595312 -1.32016092319565 -1 1.41075184576733 475 307 468 374 414 357 552 224 412 212 330 402 M17295 GO_CILIARY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PART.html Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 146/415 Gene Ontology CC GO:0044441 1.35193702340065e-05 2.79078428401992e-05 370 397.727272727273 374 1.22904121032059e-06 274 1.17835981638329 -1.13875821819741 -1 4.50717692199498 522 368 374 526 274 330 496 390 309 417 369 403 M17470 GO_AXONEME_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_PART.html Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 7/32 Gene Ontology CC GO:0044447 0.0403833897532167 0.0522183429023697 575 373.272727272727 374 0.0041136594883014 56 2.47190794454941 -4.1185261433479 -1 2.66187477694744 571 260 512 208 391 543 540 326 56 325 374 404 M17367 GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 18/32 Gene Ontology CC GO:0031312 0.0113751208079094 0.0158429393421004 300 367.272727272727 375 0.00103948775250171 184 0.899517728639886 -0.979919461288106 -1 1.35996840217823 299 540 300 512 399 238 466 215 512 375 184 405 M17396 GO_SAGA_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_TYPE_COMPLEX.html A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. 11/36 Gene Ontology CC GO:0070461 0.000447196927605906 0.0007670024455674 375 375.454545454545 375 4.06625323452604e-05 264 0.855334871360294 -0.73770359275935 -1 2.2378442562149 465 338 290 264 324 348 427 543 375 381 375 406 M17650 GO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. 102/223 Gene Ontology CC GO:0000781 0.0104457092574826 0.0146189345056294 425 314.181818181818 375 0.000954148928357213 75 1.1054459832896 -1.14195695203898 -1 1.70372961286763 75 421 375 478 387 202 245 173 423 440 237 407 M17734 GO_ESCRT_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_III_COMPLEX.html An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. 8/12 Gene Ontology CC GO:0000815 0.0023664577517549 0.00367691553901703 145 338.636363636364 375 0.000236898159022686 143 0.49227174192176 -0.49227174192176 -1 1.00652429973449 217 413 562 375 393 145 167 143 566 568 176 408 M17155 GO_TRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX.html A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). 385/832 Gene Ontology CC GO:1990234 0.00105524237123444 0.00170371533679751 360 370.454545454545 376 9.59771694839587e-05 87 1.22517272340638 -0.892823776320014 -1 2.84882257630498 360 524 413 573 376 87 303 496 283 475 185 409 M17292 GO_EXON_EXON_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXON_EXON_JUNCTION_COMPLEX.html A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. 15/51 Gene Ontology CC GO:0035145 0.0157618101456467 0.0216397298436669 200 382.545454545455 376 0.00144326189093261 172 0.469241937968611 -0.469241937968611 -1 0.656071868380558 301 542 376 515 481 199 172 347 557 521 197 410 M17711 GO_NUCLEAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE.html Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. 153/392 Gene Ontology CC GO:0031965 6.87345320852964e-05 0.000131117358235318 575 388.454545454545 377 6.24878905909963e-06 176 1.18989404950335 -1.19030274804427 -1 3.87980008660503 575 505 346 571 295 176 512 274 377 430 212 411 M17784 GO_CILIARY_BASAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASAL_BODY.html A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. 44/106 Gene Ontology CC GO:0036064 2.50523114228519e-06 6.25827845392183e-06 380 392.181818181818 378 2.27748545009112e-07 226 1.03441213103667 1.20386834517384 1 4.52064581524908 378 325 354 378 226 548 487 351 373 383 511 412 M16997 GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the nucleus. 9/15 Gene Ontology CC GO:0000176 0.00655740493021149 0.00940491327459613 380 387.272727272727 380 0.000657683547613034 284 0.579852364825619 -0.579852364825619 -1 0.986965105492369 324 284 432 420 365 318 380 393 477 491 376 413 M17258 GO_CYTOSOLIC_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PROTEASOME_COMPLEX.html A proteasome complex found in the cytosol of a cell. 7/14 Gene Ontology CC GO:0031597 0.192002422431354 0.213418077241005 290 396.454545454545 381 0.0210939651976553 289 0.494213677911569 -0.494213677911569 -1 0.278414135986399 289 381 478 367 444 299 374 395 492 519 323 414 M17358 GO_SPECIFIC_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFIC_GRANULE.html Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. 11/29 Gene Ontology CC GO:0042581 0.0104726293107672 0.0146212071053707 325 394.545454545455 382 0.000956619710163247 291 1.0269862035323 0.596508425497021 1 1.58274782993532 322 415 291 382 367 419 341 527 471 379 426 415 M17457 GO_XY_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XY_BODY.html A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. 11/32 Gene Ontology CC GO:0001741 0.290173684097525 0.317051775819224 340 403.090909090909 382 0.0306773244630363 265 1.0476812132427 -1.0476812132427 -1 0.43895657818572 372 519 265 448 480 339 354 398 539 382 338 416 M17071 GO_U2_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. 18/43 Gene Ontology CC GO:0005684 0.0206729096565578 0.0275321239204849 360 385.545454545455 383 0.00189725118213871 197 0.688352976489487 -0.688352976489487 -1 0.901959304493694 356 506 360 513 433 221 383 197 540 501 231 417 M17028 GO_NUCLEOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOID.html The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. 39/68 Gene Ontology CC GO:0009295 0.00540626034476964 0.00791093285892874 170 333.545454545455 384 0.00049269013883143 123 0.969262712874817 -1.01618491464878 -1 1.71093812688459 166 486 384 485 510 123 233 194 476 444 168 418 M17247 GO_SET1C_COMPASS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SET1C_COMPASS_COMPLEX.html A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. 5/11 Gene Ontology CC GO:0048188 0.0682600700393854 0.0857702619190539 340 374.909090909091 384 0.00704522008843818 255 0.565133789737079 -0.565133789737079 -1 0.506272274939036 337 384 475 288 461 255 431 298 406 518 271 419 M17412 GO_CLATHRIN_COAT_OF_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_COATED_PIT.html The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. 12/22 Gene Ontology CC GO:0030132 0.0839184282471183 0.0956703185933617 355 377.636363636364 384 0.00793650793650794 285 0.940911014593771 1.04977087779146 1 0.80542304426321 352 337 287 285 453 486 384 389 376 394 411 420 M17473 GO_INTERSTITIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTITIAL_MATRIX.html A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. 7/18 Gene Ontology CC GO:0005614 1.0318365184704e-06 2.9235368023328e-06 385 349.454545454545 385 1.03183699757968e-07 114 1.5187932464191 -1.42984342807021 -1 7.05915360109722 385 114 513 286 204 477 338 565 388 134 440 421 M17592 GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX.html A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. 3/20 Gene Ontology CC GO:0005892 0.000545426760076722 0.000921803120831419 370 373.363636363636 385 5.45560676996661e-05 114 1.51790848413138 -1.51790848413138 -1 3.8695776507135 368 475 540 421 513 385 399 114 296 247 349 422 M17401 GO_TCTN_B9D_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TCTN_B9D_COMPLEX.html A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins. 7/12 Gene Ontology CC GO:0036038 0.0765897756730953 0.0933942834157154 465 386.818181818182 387 0.00793650793650794 287 0.825219227777801 0.944714249311704 1 0.713637535601075 335 345 497 287 447 461 318 392 387 322 464 423 M17683 GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. 24/80 Gene Ontology CC GO:0031463 0.000367394699419791 0.000640343518484041 445 357.818181818182 387 3.34050970725099e-05 116 1.46231924917716 -0.880526054687379 -1 3.9221884808713 441 387 235 434 319 573 422 116 160 309 540 424 M17133 GO_ANAPHASE_PROMOTING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX.html A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. 11/24 Gene Ontology CC GO:0005680 0.393569280182988 0.426797455808193 315 399.909090909091 388 0.0444512785328328 312 0.511874754485057 -0.511874754485057 -1 0.158966476868352 338 388 315 429 475 345 312 334 560 506 397 425 M17047 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE.html The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 12/28 Gene Ontology CC GO:0031306 0.0670931639777789 0.0846721589064546 390 379 389 0.0062937415797662 294 1.05305677003577 1.22031675913996 1 0.948327240658446 405 312 294 352 400 547 301 344 389 389 436 426 M17739 GO_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX.html A macromolecular complex containing both protein and RNA molecules. 426/991 Gene Ontology CC GO:1990904 0.0172493577715951 0.0235144546980706 150 372.090909090909 391 0.00158055516669768 147 1.0337655238783 -0.790328231927888 -1 1.41403716462388 147 525 426 543 506 175 275 295 391 569 241 427 M17455 GO_NUCLEAR_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE_PART.html Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. 7/16 Gene Ontology CC GO:0044453 0.0765897756730953 0.0933942834157154 510 396.545454545455 392 0.00793650793650794 237 1.30874654142541 1.61661113703326 1 1.13178644877288 320 352 506 443 408 447 392 508 362 237 387 428 M17640 GO_ESC_E_Z_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESC_E_Z_COMPLEX.html A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. 13/20 Gene Ontology CC GO:0035098 0.0576168077122261 0.0730318308282164 445 398.181818181818 396 0.0053803195227275 196 1.36668480470546 -0.80502505384582 -1 1.30448795274406 444 332 196 272 396 576 460 551 298 312 543 429 M17107 GO_SMN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_COMPLEX.html A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. 9/13 Gene Ontology CC GO:0032797 0.0544865175480255 0.0696752370415017 335 417.545454545455 397 0.00558704721213991 334 0.626084966781134 -0.626084966781134 -1 0.608335412454073 334 452 449 493 397 354 356 339 544 503 372 430 M17777 GO_EARLY_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME.html A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. 195/455 Gene Ontology CC GO:0005769 0.0839184282471183 0.0956703185933617 400 367.727272727273 397 0.00793650793650794 181 1.45619783692563 -0.951686907030683 -1 1.24651177810009 397 401 181 390 448 432 477 293 272 241 513 431 M16985 GO_PHAGOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. 84/188 Gene Ontology CC GO:0045335 5.42297131388411e-06 1.18730205281251e-05 455 389.727272727273 398 4.9299860740762e-07 255 1.13967111451726 -1.05710486320304 -1 4.71446080718033 453 379 301 450 255 322 560 426 398 403 340 432 M17708 GO_BAF_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BAF_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family. 11/23 Gene Ontology CC GO:0090544 0.0272080869237986 0.0358229481593522 325 364.090909090909 398 0.00250459288240976 149 0.93591427977002 0.867958395243975 1 1.13648237529734 323 418 320 436 407 398 149 498 414 291 351 433 M17001 GO_CENTRIOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE.html A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. 54/137 Gene Ontology CC GO:0005814 0.0317533152335714 0.041243631921358 390 421.545454545455 399 0.00292919102722906 201 0.786522033118645 -0.787133367614302 -1 0.914650731654149 390 537 381 542 567 201 388 399 495 454 283 434 M17276 GO_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME.html Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. 35/70 Gene Ontology CC GO:0030684 0.079650066101207 0.0956703185933617 300 391.909090909091 399 0.00751717801395873 173 0.481581576467243 -0.481581576467243 -1 0.412234180320646 173 514 399 508 491 243 313 299 552 520 299 435 M17349 GO_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE.html Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. 196/498 Gene Ontology CC GO:0005874 2.06680453651015e-07 7.70718078776042e-07 545 370.727272727273 399 1.87891339152499e-08 143 1.38702685172839 -1.11331174535726 -1 7.12121882108032 542 443 227 399 143 297 535 463 289 301 439 436 M17443 GO_NUCLEAR_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. 29/73 Gene Ontology CC GO:0005637 0.0243187388045103 0.0322390619931352 430 349.818181818182 399 0.00223561750828275 166 0.927892148241419 1.0216376788192 1 1.1624166337797 253 399 337 464 426 324 166 431 429 404 215 437 M17699 GO_NUCLEOLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLUS.html A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. 500/1232 Gene Ontology CC GO:0005730 0.0275177026824178 0.036148254887358 250 394.272727272727 400 0.00253345871993268 192 1.12248735313947 -0.942360823324181 -1 1.35933773396066 250 565 424 577 435 192 400 382 381 485 246 438 M17050 GO_SAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_COMPLEX.html A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. 3/9 Gene Ontology CC GO:0000124 0.0289055531377003 0.0377995694877619 405 384.181818181818 401 0.00292885728404814 217 0.69731936708822 -0.69731936708822 -1 0.833094832311662 401 425 440 365 537 268 317 217 486 497 273 439 M17140 GO_GEMINI_OF_COILED_BODIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_GEMINI_OF_COILED_BODIES.html Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). 8/11 Gene Ontology CC GO:0097504 0.0620368303952858 0.0784623369113243 335 405 401 0.00638399471700234 303 0.626084966781134 -0.626084966781134 -1 0.58121190422044 303 419 455 462 401 335 335 330 543 507 365 440 M17171 GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the cytoplasm. 11/18 Gene Ontology CC GO:0000177 0.0010145386595029 0.00164258640109993 315 415.909090909091 401 9.22733472980766e-05 230 1.35561677292058 -0.596246852353799 -1 3.17020391545719 503 315 230 401 335 482 555 511 312 378 553 441 M17484 GO_CATALYTIC_STEP_2_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_STEP_2_SPLICEOSOME.html A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. 49/158 Gene Ontology CC GO:0071013 0.122752853378934 0.138847650201612 215 417.545454545455 401 0.0118354504901502 212 0.71150858844506 -0.71150858844506 -1 0.512389613404011 212 557 401 516 503 262 362 397 545 540 298 442 M17577 GO_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_COMPLEX.html Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. 14/52 Gene Ontology CC GO:0030286 0.000746494996171783 0.00123631549509252 435 327.090909090909 402 6.78862194719261e-05 61 1.40726554572251 -1.55275949571541 -1 3.43683448006571 402 431 237 219 419 336 541 433 61 407 112 443 M17390 GO_HISTONE_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_COMPLEX.html A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. 47/95 Gene Ontology CC GO:0035097 0.0839184282471183 0.0956703185933617 485 368.181818181818 403 0.00793650793650794 142 1.8796685588813 -0.980663364843312 -1 1.60900535734424 484 403 213 307 403 275 481 530 142 399 413 444 M17078 GO_COPI_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_VESICLE_COAT.html One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. 9/13 Gene Ontology CC GO:0030126 0.00619492619043899 0.00897410360419483 555 373.636363636364 405 0.000621226395282162 108 1.75559129427662 1.58768999510452 1 3.01821782510243 555 316 446 132 363 474 573 405 108 211 527 445 M17311 GO_EARLY_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding an early endosome. 84/194 Gene Ontology CC GO:0031901 0.0839184282471183 0.0956703185933617 540 400.363636363636 405 0.00793650793650794 183 1.46030353368396 -0.902032361849398 -1 1.25002628013307 537 380 183 318 472 405 505 564 265 230 545 446 M17007 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE.html A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. 23/33 Gene Ontology CC GO:0000407 0.020249269475123 0.027092772584771 395 413.090909090909 406 0.00185800778783521 326 1.01058358829652 -1.10210063859912 -1 1.33011378031309 460 406 326 531 379 392 483 425 337 411 394 447 M17089 GO_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME.html An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. 141/339 Gene Ontology CC GO:0005840 0.00402888559326618 0.00603289086245557 470 314.909090909091 406 0.000366934791843668 113 0.607247433438813 -0.606854856218972 -1 1.13193800935831 113 466 419 417 406 119 187 202 469 487 179 448 M17130 GO_CHROMOSOMAL_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOMAL_REGION.html Any subdivision of a chromosome along its length. 208/530 Gene Ontology CC GO:0098687 0.0839184282471183 0.0956703185933617 155 399.727272727273 406 0.00793650793650794 155 1.11030095313543 -1.09510965484928 -1 0.950421888165196 155 551 406 524 450 305 387 328 457 478 356 449 M17397 GO_CELL_DIVISION_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION_SITE.html The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. 31/80 Gene Ontology CC GO:0032153 0.00680912828923071 0.009717718891791 490 375.363636363636 406 0.000620935882832787 215 1.42929095585722 -0.807572261562044 -1 2.41573884196583 487 473 215 455 362 334 421 302 259 415 406 450 M17448 GO_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases. 14/25 Gene Ontology CC GO:0000178 0.000999449244337003 0.00162270130119884 475 389.181818181818 406 9.0900325293733e-05 256 1.15347842713275 -0.579852364825619 -1 2.70261337113638 471 267 256 435 334 364 458 486 325 406 479 451 M17147 GO_SEX_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_CHROMOSOME.html A chromosome involved in sex determination. 20/46 Gene Ontology CC GO:0000803 0.313162414917745 0.340881122076189 315 425.727272727273 407 0.0335741226865329 284 1.0476812132427 -1.0476812132427 -1 0.41126346352623 312 541 284 554 523 316 397 407 562 427 360 452 M17188 GO_NUCLEAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_BODY.html Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. 213/505 Gene Ontology CC GO:0016604 0.00914589228779586 0.0129250018150269 405 409.818181818182 408 0.000834921507333561 149 1.24955906586351 -0.81873713586989 -1 1.98196947576198 403 527 408 566 478 149 373 538 341 473 252 453 M17356 GO_PERICENTRIC_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIC_HETEROCHROMATIN.html Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. 10/18 Gene Ontology CC GO:0005721 0.44884336785141 0.481319975172755 505 419.545454545455 408 0.0527174244971845 234 0.402037363222372 -0.452471042965067 -1 0.107225389875271 298 501 234 465 501 344 393 408 563 525 383 454 M16989 GO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME.html A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. 509/1183 Gene Ontology CC GO:0005694 0.0765897756730953 0.0933942834157154 485 415.636363636364 409 0.00793650793650794 239 1.36992486174605 -1.13191976013174 -1 1.18469276332783 239 549 431 560 482 283 409 379 396 483 361 455 M17116 GO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE.html A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. 682/1632 Gene Ontology CC GO:0005773 3.84778146706804e-08 2.61649139760626e-07 555 349.545454545455 409 3.84778153369244e-09 61 1.46253372699525 -1.20302409276311 -1 8.0851848390893 554 162 453 409 61 273 566 560 248 128 431 456 M17399 GO_NUCLEAR_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_HETEROCHROMATIN.html A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. 25/40 Gene Ontology CC GO:0005720 0.191582387473666 0.213361502812676 330 418.909090909091 410 0.0191485204687224 276 0.982608923239582 -1.08048577610412 -1 0.553648113940217 329 559 276 541 566 309 410 367 501 436 314 457 M17054 GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of H4 histone acetyltransferase activity. 18/27 Gene Ontology CC GO:1902562 0.0566978703731678 0.0720249869795406 485 361.454545454545 411 0.00529218819530244 29 3.62378143318192 -1.87451840457573 -1 3.47721921493762 411 499 170 267 556 537 482 234 29 307 484 458 M17382 GO_SIN3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_COMPLEX.html A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. 8/19 Gene Ontology CC GO:0016580 0.0101166541654743 0.0142233451980315 455 368.818181818182 411 0.00101630074489709 159 0.557826828078275 -0.557826828078275 -1 0.865311264290469 452 344 495 411 534 257 159 238 458 527 182 459 M17841 GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT.html A distinct region of the endoplasmic reticulum 10/22 Gene Ontology CC GO:0098827 0.00397230922130453 0.00597915294248442 500 417.636363636364 411 0.000361772707863567 256 0.732092161755853 0.815353060885614 1 1.36704426016051 496 278 318 256 354 476 529 411 344 577 555 460 M17385 GO_CILIARY_TRANSITION_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TRANSITION_ZONE.html A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition. 15/25 Gene Ontology CC GO:0035869 0.00335042825472473 0.00509617771376551 570 424.181818181818 412 0.00030504923644057 236 0.774991651251786 -0.661843252545175 -1 1.49231942194334 570 236 339 306 349 457 530 573 399 412 495 461 M17797 GO_U12_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U12_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. 14/35 Gene Ontology CC GO:0005689 0.25706026252186 0.283551205606174 415 429.636363636364 412 0.026651177121567 331 0.64692607641236 -0.771530386899393 -1 0.297398239330259 412 439 349 392 423 400 485 331 517 573 405 462 M17567 GO_POLYSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSOME.html A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. 15/60 Gene Ontology CC GO:0005844 0.0839184282471183 0.0956703185933617 420 382.636363636364 413 0.00793650793650794 176 1.90973181959943 -0.717915985173146 -1 1.634739696028 418 476 313 439 527 325 326 338 176 413 458 463 M17783 GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX.html A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. 9/24 Gene Ontology CC GO:0000159 0.0765897756730953 0.0933942834157154 380 399 413 0.00793650793650794 69 2.09947451747202 -0.458886920693445 -1 1.81559899558467 380 479 572 263 434 562 413 559 69 361 297 464 M17461 GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the inner mitochondrial membrane. 63/124 Gene Ontology CC GO:0098800 0.00989227543379568 0.0139456956115461 470 329.909090909091 414 0.000903367088959614 76 0.589759272796808 -0.589759272796808 -1 0.919086297531839 76 451 414 469 431 152 180 294 494 468 200 465 M17721 GO_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE.html The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. 180/399 Gene Ontology CC GO:0005819 2.21718495882064e-06 5.77267074864112e-06 560 417.363636363636 414 2.01562472120723e-07 217 1.39995301358091 -0.89296105777582 -1 6.15939765192905 559 510 262 395 217 375 542 414 358 437 522 466 M17015 GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK.html A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. 10/15 Gene Ontology CC GO:0071782 0.00397230922130453 0.00597915294248442 495 409.454545454545 415 0.000361772707863567 255 0.732092161755853 0.815353060885614 1 1.36704426016051 495 277 317 255 353 475 528 415 343 492 554 467 M17608 GO_PHAGOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a phagocytic vesicle. 55/111 Gene Ontology CC GO:0030670 0.0839184282471183 0.0956703185933617 405 450.909090909091 415 0.00793650793650794 331 1.15320120582231 -0.935080079978179 -1 0.987144772040443 531 402 331 415 554 388 559 553 405 421 401 468 M17611 GO_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUCHROMATIN.html A dispersed and relatively uncompacted form of chromatin. 25/56 Gene Ontology CC GO:0000791 0.0839184282471183 0.0956703185933617 415 410.818181818182 415 0.00793650793650794 189 1.71493718476287 1.9594900915017 1 1.4679942736447 415 497 189 463 552 525 358 306 386 377 451 469 M17053 GO_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). 57/168 Gene Ontology CC GO:0015934 0.00641414913019267 0.0092453321627216 500 331.272727272727 416 0.000584811492171907 136 0.5631100752632 -0.5631100752632 -1 0.961983004879629 181 484 416 433 430 136 163 232 498 498 173 470 M17458 GO_MITOCHONDRIAL_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_PART.html Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. 95/199 Gene Ontology CC GO:0044455 0.0196666785077241 0.0264972964509663 445 341.272727272727 417 0.00180406536648271 144 0.762007028759901 -0.674970824554688 -1 1.0091176990237 144 444 417 522 441 179 216 236 456 464 235 471 M17250 GO_NODE_OF_RANVIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NODE_OF_RANVIER.html An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. 8/32 Gene Ontology CC GO:0033268 0.000174920941560609 0.000316941392545555 255 402.727272727273 418 1.74934711887264e-05 252 1.07972961795997 -1.09139547309893 -1 3.172992260057 519 396 477 339 311 445 539 253 418 252 481 472 M17542 GO_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX.html Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. 104/251 Gene Ontology CC GO:0005681 0.184119780751004 0.205843778092999 245 429.090909090909 418 0.0183288299466819 242 0.782508805212295 -0.812108139810295 -1 0.451139807463978 242 553 418 563 575 284 405 369 518 482 311 473 M17031 GO_HOLO_TFIIH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOLO_TFIIH_COMPLEX.html A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. 7/12 Gene Ontology CC GO:0005675 0.00800697640936542 0.0113710868909416 450 415.363636363636 419 0.000803597381812779 338 0.635252051037803 -0.386790298712793 -1 1.03727346847511 446 339 437 338 366 352 406 524 419 495 447 474 M17102 GO_NUCLEOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLAR_PART.html Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. 31/65 Gene Ontology CC GO:0044452 0.0839184282471183 0.0956703185933617 260 401.090909090909 419 0.00793650793650794 259 0.809446919122789 -0.668619901003554 -1 0.692888958578866 259 459 391 520 496 311 419 317 442 450 348 475 M17441 GO_ENDORIBONUCLEASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_COMPLEX.html A protein complex which is capable of endoribonuclease activity. 11/22 Gene Ontology CC GO:1902555 0.0893626368726594 0.101676386048026 355 407.090909090909 420 0.00847393982416692 257 0.652957791208046 -0.652957791208046 -1 0.544432164265721 316 478 351 519 420 351 439 257 466 535 346 476 M17560 GO_INTRACILIARY_TRANSPORT_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE.html A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. 19/39 Gene Ontology CC GO:0030990 2.66438866277362e-05 5.32877732554724e-05 515 407.909090909091 422 2.42220084668392e-06 254 0.780665455056156 -0.760574073960924 -1 2.8018385202885 486 254 307 315 283 512 511 422 468 385 544 477 M17617 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE.html The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 27/59 Gene Ontology CC GO:0098573 0.018921297482721 0.0256124354684139 425 432.727272727273 422 0.00173509260225883 187 0.916046139491313 -0.794337891631854 -1 1.22445904285814 524 422 372 545 576 331 574 187 421 423 385 478 M17713 GO_SWI_SNF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_COMPLEX.html A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. 8/15 Gene Ontology CC GO:0016514 0.0765897756730953 0.0933942834157154 480 418.909090909091 422 0.00793650793650794 254 1.11632701059392 -1.07182604882211 -1 0.965384230285483 479 382 559 322 422 566 300 451 390 254 483 479 M17521 GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. 3/14 Gene Ontology CC GO:0031235 1.28121882708871e-05 2.66382907214848e-05 450 364.909090909091 424 1.28122621399623e-06 134 1.20327527642467 -1.33409602334957 -1 4.62291150860098 447 134 526 198 275 489 572 424 330 173 446 480 M17145 GO_SPINDLE_POLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_POLE.html Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. 77/171 Gene Ontology CC GO:0000922 0.00634327149970139 0.00916602731706852 430 411.818181818182 426 0.000578330478010234 289 1.23783870951613 -0.953674910856981 -1 2.11854112626073 427 512 289 416 361 313 469 491 440 426 386 481 M17826 GO_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of acetyltransferase activity. 57/110 Gene Ontology CC GO:1902493 0.0752092978693298 0.0933942834157154 430 399 426 0.00708278302525503 116 1.59829762697585 -0.879339661185649 -1 1.38218692939365 426 536 342 472 571 241 364 502 116 446 373 482 M17737 GO_COHESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_COHESIN_COMPLEX.html A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). 8/14 Gene Ontology CC GO:0008278 0.179812671985252 0.201418070557123 255 424.272727272727 427 0.0196270824635751 231 1.11242630096685 1.11242630096685 1 0.650167264307246 251 520 563 484 427 381 231 542 556 344 368 483 M17172 GO_LIPID_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE.html An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. 41/94 Gene Ontology CC GO:0005811 0.0255527744184263 0.0337974911072092 565 429.363636363636 428 0.00235040771788984 211 1.7541927967411 -1.4536010986735 -1 2.1673616354133 561 428 211 538 382 378 557 521 360 283 504 484 M17317 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX.html A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. 14/31 Gene Ontology CC GO:0097526 0.722220046777225 0.748106069959205 345 439.636363636364 429 0.109923459546838 341 0.679165243391042 -0.679165243391042 -1 0.0718893697747064 341 493 385 376 515 393 446 429 519 522 417 485 M17556 GO_SMN_SM_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_SM_PROTEIN_COMPLEX.html A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. 10/21 Gene Ontology CC GO:0034719 0.751288328949336 0.772677320520847 470 438.090909090909 429 0.118822726371718 335 0.246813780768333 -0.30365717288258 -1 0.0232141466161261 365 448 335 466 468 397 382 419 558 552 429 486 M17605 GO_MICROTUBULE_ASSOCIATED_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ASSOCIATED_COMPLEX.html Any multimeric complex connected to a microtubule. 62/174 Gene Ontology CC GO:0005875 0.0839184282471183 0.0956703185933617 580 444.909090909091 431 0.00793650793650794 274 1.18986626472998 -1.29543919380256 -1 1.01853029115085 576 513 274 460 561 401 493 413 422 431 350 487 M17297 GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX.html A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. 41/83 Gene Ontology CC GO:0070603 0.0839184282471183 0.0956703185933617 460 404.818181818182 432 0.00793650793650794 295 1.37115543025318 -0.850174705792358 -1 1.1737149475663 459 492 324 461 432 295 468 446 302 364 410 488 M17231 GO_PRONUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRONUCLEUS.html The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. 9/23 Gene Ontology CC GO:0045120 0.0144458481480273 0.0198802386418091 360 439 433 0.0014540623546632 357 1.57400998203222 1.97554943233383 1 2.24940027115028 513 433 474 437 374 545 379 359 394 357 564 489 M17440 GO_SMOOTH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_ENDOPLASMIC_RETICULUM.html The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. 23/64 Gene Ontology CC GO:0005790 0.0839184282471183 0.0956703185933617 280 410.363636363636 433 0.00793650793650794 277 0.946773209946783 -1.03412396691012 -1 0.810441120048775 480 571 316 396 525 277 472 280 459 433 305 490 M17563 GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR.html A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. 14/26 Gene Ontology CC GO:0030687 0.454918773000689 0.486931575545182 570 446.181818181818 433 0.0536714785106822 332 0.329569586722602 -0.329569586722602 -1 0.0865040008417313 332 518 364 479 568 350 433 343 568 553 400 491 M17555 GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX.html A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. 8/22 Gene Ontology CC GO:0005732 0.435369722646862 0.467739218754435 435 456.090909090909 434 0.0555555555555556 391 0.799072968462919 -0.799072968462919 -1 0.221461380043976 410 416 535 391 465 431 434 428 485 551 471 492 M17132 GO_MITOTIC_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE.html A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. 33/75 Gene Ontology CC GO:0072686 0.0839184282471183 0.0956703185933617 435 415.727272727273 435 0.00793650793650794 198 1.24718851397612 -0.820263800251649 -1 1.06759849403298 435 386 198 293 548 501 495 455 426 297 539 493 M17230 GO_CILIARY_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TIP.html Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. 25/63 Gene Ontology CC GO:0097542 0.000143073960094557 0.000264206865605923 310 420.818181818182 435 1.3007569596282e-05 307 0.70464599427004 -0.639197891029983 -1 2.11750952325723 551 310 366 470 307 342 513 492 448 435 395 494 M17061 GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 133/294 Gene Ontology CC GO:0061695 2.74353809951447e-06 6.71934331152273e-06 540 413.727272727273 438 2.4941286553497e-07 232 1.16454142576996 -0.92854546616418 -1 5.05915005234734 536 456 388 568 232 289 443 537 284 438 380 495 M17579 GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX.html A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. 13/27 Gene Ontology CC GO:0032806 0.0162348563589684 0.0221837989964154 485 433.181818181818 438 0.00148690124523433 363 0.635252051037803 -0.386790298712793 -1 0.882426721560286 481 438 363 447 375 370 377 493 473 557 391 496 M17847 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. 16/39 Gene Ontology CC GO:0000307 0.0839184282471183 0.0956703185933617 440 452.181818181818 438 0.00793650793650794 311 1.62817921878069 1.62817921878069 1 1.39372891364157 386 573 311 540 549 531 438 394 436 354 462 497 M17550 GO_INTRACILIARY_TRANSPORT_PARTICLE_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE_B.html The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. 12/24 Gene Ontology CC GO:0030992 0.00516851938078679 0.00760153740991035 440 438.636363636364 439 0.000470972910102441 302 0.746404505293443 -0.656289373627267 -1 1.328410651662 439 394 302 403 357 529 441 482 508 396 574 498 M17497 GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX.html A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. 11/24 Gene Ontology CC GO:0046540 0.698152987361708 0.725777745854437 405 464.454545454545 440 0.103174603174603 370 0.679165243391042 -0.679165243391042 -1 0.0793956309530925 404 575 370 394 553 416 467 440 514 542 434 499 M17672 GO_RNAI_EFFECTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNAI_EFFECTOR_COMPLEX.html Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. 4/11 Gene Ontology CC GO:0031332 0.0747656118700001 0.0933359042351189 440 451.636363636364 440 0.00774070334845873 251 0.30580171019383 -0.356194599325157 -1 0.264520926659286 438 464 552 440 512 396 424 251 564 564 363 500 M17499 GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 71/125 Gene Ontology CC GO:0000779 0.597318307603006 0.626587988737818 510 438.818181818182 442 0.0793650793650794 232 0.935146573438236 -0.934421296452204 -1 0.159446383666949 232 555 386 528 509 374 442 423 509 465 404 501 M17425 GO_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLTRANSFERASE_COMPLEX.html A protein complex that possesses methyltransferase activity. 57/119 Gene Ontology CC GO:0034708 0.0839184282471183 0.0956703185933617 505 424.909090909091 443 0.00793650793650794 220 1.8796685588813 -0.980663364843312 -1 1.60900535734424 504 491 248 407 443 361 565 554 220 424 457 502 M17540 GO_CHROMOCENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOCENTER.html A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure. 8/17 Gene Ontology CC GO:0010369 0.0765897756730953 0.0933942834157154 385 450.545454545455 444 0.00793650793650794 343 1.92234372978871 1.92234372978871 1 1.66241830802371 382 482 531 444 493 518 428 507 420 343 408 503 M17075 GO_ACROSOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_MEMBRANE.html The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. 7/29 Gene Ontology CC GO:0002080 0.000500308683732235 0.000851594520553397 535 390.636363636364 445 5.00421358386766e-05 52 1.1415515309293 1.34627084133185 1 2.94312271063561 535 52 445 265 327 536 521 503 342 236 535 504 M17501 GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX.html Any of the heteromeric enzymes that act in the TCA cycle. 5/13 Gene Ontology CC GO:0045239 0.271486528117256 0.298893739527188 375 440.545454545455 445 0.0311785208316106 310 0.504835410821326 -0.504835410821326 -1 0.222373997331586 375 474 520 445 449 310 369 375 567 543 419 505 M17538 GO_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN.html A compact and highly condensed form of chromatin. 42/86 Gene Ontology CC GO:0000792 0.186516678879986 0.208120927398904 285 424 449 0.0185913588743036 282 0.953144544047919 -1.0191860888984 -1 0.545692168173467 285 569 329 558 540 282 449 342 530 460 320 506 M17111 GO_CD40_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD40_RECEPTOR_COMPLEX.html A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. 9/16 Gene Ontology CC GO:0035631 0.0276054097808596 0.0361812400302423 540 432.181818181818 450 0.00279544543386635 265 1.73947977102516 -1.06951219709846 -1 2.105941372469 538 295 450 351 385 490 464 566 403 265 547 507 M17706 GO_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE.html Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. 35/99 Gene Ontology CC GO:0005643 0.0839184282471183 0.0956703185933617 385 439.818181818182 451 0.00793650793650794 325 0.928671006423201 -1.02379337899337 -1 0.794945520926444 381 496 343 537 526 407 504 325 451 456 412 508 M17114 GO_CYTOSOLIC_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PART.html Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. 123/339 Gene Ontology CC GO:0044445 0.00278655885251887 0.00430650004480188 510 405.909090909091 454 0.000253644966239131 143 1.01247028699764 -0.746559873335307 -1 2.01178430922449 456 528 420 509 454 157 381 506 439 472 143 509 M17781 GO_CYTOSOLIC_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_RIBOSOME.html A ribosome located in the cytosol. 67/214 Gene Ontology CC GO:0022626 0.197427594965909 0.219027159098455 485 445 454 0.0197953745262293 300 0.564120070983778 -0.564120070983778 -1 0.312458115187535 485 530 427 454 460 300 378 450 522 572 317 510 M17120 GO_NUCLEAR_SPECK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_SPECK.html A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. 122/306 Gene Ontology CC GO:0016607 0.00651561164352692 0.00936821773621532 465 413.363636363636 455 0.000594089903836439 137 1.29780206092068 -0.690151205205925 -1 2.21083916021239 461 529 400 546 455 137 420 545 336 467 251 511 M17137 GO_MALE_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GERM_CELL_NUCLEUS.html The nucleus of a male germ cell, a reproductive cell in males. 12/33 Gene Ontology CC GO:0001673 0.736622903332843 0.760300068082827 515 452.181818181818 455 0.114221217369535 279 1.0476812132427 -1.0476812132427 -1 0.104719499001065 515 543 279 405 466 424 526 434 536 391 455 512 M17201 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX.html A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. 10/56 Gene Ontology CC GO:0008328 0.000239426072856833 0.000427124290466819 560 393.181818181818 455 2.17683757795474e-05 209 1.10664560802065 -1.16373319384286 -1 3.13165902568821 557 209 218 225 315 455 568 550 463 279 486 513 M17757 GO_NBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NBAF_COMPLEX.html A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 8/16 Gene Ontology CC GO:0071565 0.0765897756730953 0.0933942834157154 455 453.727272727273 455 0.00793650793650794 255 1.11632701059392 -1.07182604882211 -1 0.965384230285483 455 488 568 354 452 578 407 517 410 255 507 514 M16978 GO_CLATHRIN_SCULPTED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_SCULPTED_VESICLE.html A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. 5/26 Gene Ontology CC GO:0060198 0.238135863705728 0.263178832164266 450 447.181818181818 456 0.0268321498405432 174 0.471839761817384 0.471839761817384 1 0.229740398587387 462 449 428 174 424 492 456 448 555 489 542 515 M17165 GO_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_NUCLEUS.html The nucleus of a germ cell, a reproductive cell in multicellular organisms. 12/37 Gene Ontology CC GO:0043073 0.736622903332843 0.760300068082827 520 453.181818181818 456 0.114221217369535 280 1.0476812132427 -1.0476812132427 -1 0.104719499001065 516 544 280 406 467 425 527 435 537 392 456 516 M17226 GO_U2_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U2. 9/24 Gene Ontology CC GO:0005686 0.820905450246538 0.838309806082154 415 465.636363636364 457 0.15800747307758 413 0.418488525595296 -0.418488525595296 -1 0.0269185434834655 442 480 472 457 492 413 414 454 534 516 448 517 M17703 GO_TELOMERE_CAP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAP_COMPLEX.html A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. 5/14 Gene Ontology CC GO:0000782 0.481063017846562 0.513015543017182 570 462.090909090909 457 0.0634920634920635 356 0.484341082948553 -0.484341082948553 -1 0.117910323659119 499 370 557 356 457 406 415 567 491 566 399 518 M17220 GO_DNA_REPLICATION_FACTOR_A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_FACTOR_A_COMPLEX.html A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. 11/14 Gene Ontology CC GO:0005662 0.00028762864172206 0.000506857789376068 380 449 458 2.61514775690034e-05 317 0.779785094119101 -0.727820739497245 -1 2.15800591464446 562 376 325 379 317 509 556 458 432 515 510 519 M17248 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY.html A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. 42/84 Gene Ontology CC GO:0000932 0.0839184282471183 0.0956703185933617 395 467.090909090909 459 0.00793650793650794 312 1.32420886079915 -0.549134984171658 -1 1.13352839130088 510 558 395 562 437 312 534 535 444 459 392 520 M17237 GO_PCG_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PCG_PROTEIN_COMPLEX.html A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. 33/52 Gene Ontology CC GO:0031519 0.0839184282471183 0.0956703185933617 495 445.181818181818 460 0.00793650793650794 303 1.18337228405212 -1.02102061821757 -1 1.01297140318668 494 429 303 533 483 386 486 495 409 419 460 521 M17380 GO_DNA_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR_COMPLEX.html A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 24/43 Gene Ontology CC GO:1990391 0.307308214796846 0.335139902174673 375 441.272727272727 461 0.0328281676741057 315 0.621688093404678 -0.621688093404678 -1 0.247891999572401 373 487 387 496 538 315 411 461 505 526 355 522 M17003 GO_MICROTUBULE_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. 567/1355 Gene Ontology CC GO:0015630 8.4915473221536e-05 0.000160395893862901 550 452.363636363636 462 8.49187181829675e-06 231 1.25689232969024 -0.977693699907251 -1 4.00585532781487 550 548 433 574 301 231 570 576 361 462 370 523 M17189 GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. 7/32 Gene Ontology CC GO:0032281 6.74423342230589e-05 0.000129078374771285 580 439.727272727273 462 6.744438112129e-06 241 0.896643034485734 -0.884542148485253 -1 2.92874322703801 577 241 462 348 298 471 575 442 415 510 498 524 M17253 GO_MOTILE_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM.html A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles. 50/165 Gene Ontology CC GO:0031514 3.82160520418882e-05 7.46245881088222e-05 430 431.909090909091 462 3.47424690059117e-06 263 1.2094172580158 1.13353331807619 1 4.1920898836959 429 485 263 492 289 506 462 499 384 410 532 525 M17066 GO_TELOMERASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_HOLOENZYME_COMPLEX.html Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. 9/23 Gene Ontology CC GO:0005697 0.503023918521842 0.534462913429458 445 462.818181818182 463 0.0675328332318966 360 0.629402526969927 -0.629402526969927 -1 0.143823141011077 463 441 444 424 498 391 550 360 553 499 468 526 M17246 GO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME.html A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. 269/639 Gene Ontology CC GO:0005813 0.0270980741754704 0.0357595590717395 475 439.636363636364 463 0.00249433827688294 250 1.07716757382062 -0.909056710187541 -1 1.30870274792449 473 566 407 575 384 250 494 467 425 463 332 527 M17391 GO_MICROTUBULE_PLUS_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_PLUS_END.html The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. 11/22 Gene Ontology CC GO:0035371 0.514011397665828 0.545135023579539 500 449.454545454545 463 0.0634920634920635 208 2.14206869535491 2.14206869535491 1 0.474037454831576 318 576 208 459 572 499 423 549 497 380 463 528 M17409 GO_CHLORIDE_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_COMPLEX.html An ion channel complex through which chloride ions pass. 8/50 Gene Ontology CC GO:0034707 0.0120705426315215 0.016730872040814 495 451.090909090909 463 0.00121366123755494 341 1.23888668805917 -1.57456467644348 -1 1.84841481525243 492 463 499 504 370 429 455 523 472 341 414 529 M17339 GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT.html The large subunit of a ribosome located in the cytosol. 34/129 Gene Ontology CC GO:0022625 0.277525890567408 0.304383234815867 465 452.363636363636 464 0.0291197589967273 326 0.559297719424663 -0.559297719424663 -1 0.242651557756867 464 532 411 451 494 326 357 520 561 523 337 530 M16994 GO_RETROMER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROMER_COMPLEX.html A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. 15/25 Gene Ontology CC GO:0030904 0.161385165508919 0.181127428474088 450 438.090909090909 465 0.0158730158730159 210 1.36595208779391 1.69136861031711 1 0.851245954111058 449 436 210 316 555 534 500 558 465 277 519 531 M17036 GO_NUCLEAR_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE.html The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. 9/30 Gene Ontology CC GO:0005640 0.0765897756730953 0.0933942834157154 570 473.090909090909 465 0.00793650793650794 349 0.705830205089971 0.565478081745797 1 0.610391268694335 489 364 438 349 451 569 465 571 446 496 566 532 M17551 GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX.html RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 6/15 Gene Ontology CC GO:0005736 0.435369722646862 0.467739218754435 405 463 466 0.0555555555555556 380 0.631812587178997 -0.631812587178997 -1 0.175104964495748 476 405 534 380 505 434 451 404 488 550 466 533 M17750 GO_MICROTUBULE_ORGANIZING_CENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER.html An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. 354/819 Gene Ontology CC GO:0005815 0.0191962817164692 0.0259239505423345 510 442.454545454545 466 0.0017605323266739 224 1.13529607604676 -0.920020176560093 -1 1.51252019686521 508 550 409 567 377 224 518 494 400 466 354 534 M17187 GO_MCM_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MCM_COMPLEX.html A hexameric protein complex required for the initiation and regulation of DNA replication. 6/11 Gene Ontology CC GO:0042555 0.973556694131186 0.976937099319142 470 472.636363636364 468 0.304604982166483 358 0.362254522722536 -0.362254522722536 -1 0.00308036978698854 413 455 461 358 520 467 491 468 554 509 503 535 M17584 GO_SPINDLE_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MICROTUBULE.html Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. 35/78 Gene Ontology CC GO:0005876 0.0839184282471183 0.0956703185933617 470 424.727272727273 468 0.00793650793650794 188 1.63002972062721 -1.16330266062827 -1 1.39531295476405 509 468 188 295 547 423 525 522 363 363 469 536 M17218 GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT.html The small subunit of a ribosome located in the cytosol. 33/76 Gene Ontology CC GO:0022627 0.499491455491708 0.531687037337398 475 457.454545454545 471 0.0609823134197516 371 0.568942422542893 -0.568942422542893 -1 0.131087924828213 545 531 405 397 471 372 473 453 500 514 371 537 M17224 GO_AXON_INITIAL_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_INITIAL_SEGMENT.html Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. 7/26 Gene Ontology CC GO:0043194 0.275742742869669 0.303002481708495 500 449.909090909091 471 0.0317460317460317 315 1.50510212232629 -1.50510212232629 -1 0.65548966890446 497 547 471 408 439 514 315 385 478 319 576 538 M17272 GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. 2/14 Gene Ontology CC GO:0017146 0.00584774022845056 0.00853533801021319 570 399.9 471 0.000651443852880416 104 1.42164946832301 -1.72211528455808 -1 2.47009709500899 568 104 481 NA 364 507 497 374 461 141 502 539 M17430 GO_SYNAPTONEMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX.html A proteinaceous scaffold found between homologous chromosomes during meiosis. 21/151 Gene Ontology CC GO:0000795 0.394793444800202 0.427323241750031 340 452.454545454545 471 0.0446267948922699 276 1.11242630096685 1.11242630096685 1 0.344975742525923 336 560 314 548 464 500 276 471 574 429 505 540 M17435 GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX.html A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. 5/10 Gene Ontology CC GO:0031414 0.58788490535177 0.617813591442406 430 461 471 0.0848298377002061 373 0.168577581682262 -0.201455754911509 -1 0.0296081381503136 396 471 503 430 507 373 429 476 531 533 422 541 M17472 GO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE.html A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 82/151 Gene Ontology CC GO:0000776 0.7791583997046 0.799917504492466 475 458.727272727273 471 0.128292084498548 270 0.934421296452204 -0.934421296452204 -1 0.0760859917772284 270 554 396 523 539 403 474 457 526 471 433 542 M17202 GO_ORGANELLE_MEMBRANE_CONTACT_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_CONTACT_SITE.html A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. 4/13 Gene Ontology CC GO:0044232 0.829708980873022 0.845805627768266 505 470.909090909091 472 0.162240860487946 357 0.262915503823165 -0.323042421924275 -1 0.0160569272392653 501 472 464 357 484 456 502 421 542 511 470 543 M17325 GO_RIBONUCLEOPROTEIN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_GRANULE.html A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. 98/225 Gene Ontology CC GO:0035770 0.0839184282471183 0.0956703185933617 555 431.363636363636 474 0.00793650793650794 184 2.25493150440958 -1.54124382088969 -1 1.93023277928744 553 552 268 506 474 321 558 477 184 428 424 544 M17571 GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX.html RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 9/21 Gene Ontology CC GO:0005666 0.282148883985523 0.308867528302334 490 461.636363636364 476 0.0326058919138219 315 0.865031143631162 -0.865031143631162 -1 0.370681162030502 450 489 538 432 544 382 476 315 489 554 409 545 M17242 GO_COPI_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a COPI-coated vesicle. 11/20 Gene Ontology CC GO:0030663 0.0839184282471183 0.0956703185933617 530 398.363636363636 477 0.00793650793650794 153 1.75559129427662 1.58768999510452 1 1.50279444495421 527 446 250 190 477 519 543 489 153 232 556 546 M17062 GO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CENTROMERIC_REGION.html The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 112/318 Gene Ontology CC GO:0000775 0.747053672266087 0.769691662334757 480 464.727272727273 478 0.117469237453972 305 0.913790864494224 -0.894793431805641 -1 0.087244442582203 305 568 402 525 529 394 478 452 535 480 444 547 M17576 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE.html The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 12/24 Gene Ontology CC GO:0031304 0.557443745451391 0.58688977207815 515 482.454545454545 483 0.0714285714285714 365 0.549446034014064 -0.549446034014064 -1 0.106798947868645 512 447 365 483 479 422 563 525 502 555 454 548 M17768 GO_MAST_CELL_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_GRANULE.html Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. 9/48 Gene Ontology CC GO:0042629 0.0999825195443208 0.113536142036576 390 465.818181818182 486 0.0104788198941904 206 0.550952167649777 0.65181956031562 1 0.437209136542705 388 481 570 486 551 451 206 402 521 571 497 549 M17206 GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX.html A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. 8/18 Gene Ontology CC GO:0005852 0.105137755317865 0.11915612269358 485 446 487 0.0110470768140266 274 0.339151676482574 -0.339151676482574 -1 0.26315684622634 483 502 466 494 487 288 274 533 573 512 294 550 M17846 GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX.html A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. 30/70 Gene Ontology CC GO:0030532 0.704916489476108 0.731493233244506 550 483.818181818182 488 0.10502031695301 389 0.608871166828258 -0.608871166828258 -1 0.06943579480537 419 533 397 547 545 389 488 449 550 578 427 551 M17704 GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX.html Any complex formed of proteins that act in nucleotide-excision repair. 11/16 Gene Ontology CC GO:0000109 0.803107697791398 0.823042995254305 480 494.090909090909 489 0.137341360543084 332 0.631812587178997 -0.631812587178997 -1 0.0448771361840535 544 494 332 474 476 469 562 480 548 567 489 552 M17289 GO_NUCLEAR_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_REPLICATION_FORK.html The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 30/42 Gene Ontology CC GO:0043596 0.0839184282471183 0.0956703185933617 490 476.181818181818 490 0.00793650793650794 273 1.55062352650492 -0.768662651709901 -1 1.32734075732708 552 515 273 425 490 487 544 557 385 448 562 553 M17745 GO_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_PREINITIATION_COMPLEX.html A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. 7/16 Gene Ontology CC GO:0070993 0.392565250260516 0.426508862125147 490 481.090909090909 490 0.0486288809766972 340 0.339151676482574 -0.339151676482574 -1 0.105408832526341 482 490 565 487 543 340 372 490 572 570 381 554 M17022 GO_U1_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U1_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U1. 6/22 Gene Ontology CC GO:0005685 0.942639188668706 0.947646699649188 535 497.727272727273 494 0.248616716947697 436 0.229108765199307 -0.226421174447305 -1 0.00449102918169928 534 523 436 441 502 458 479 488 570 494 550 555 M17546 GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX.html RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 6/22 Gene Ontology CC GO:0005665 0.806494995060233 0.825051517070468 490 503.818181818182 495 0.151466055795231 435 0.178540950783513 -0.190079716826522 -1 0.012520987512643 488 578 532 495 562 444 437 485 538 548 435 556 M17639 GO_CONDENSED_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. 135/358 Gene Ontology CC GO:0000793 0.232850105696956 0.257830193664445 500 485.454545454545 496 0.0238095238095238 392 1.04086319047426 -0.876922701924393 -1 0.514598288727487 448 567 392 529 500 435 520 505 474 474 496 557 M17533 GO_MIDBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBODY.html A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. 90/198 Gene Ontology CC GO:0030496 0.0839184282471183 0.0956703185933617 515 442.363636363636 497 0.00793650793650794 267 1.17768376201319 -0.798449716581806 -1 1.0081019928412 529 511 295 497 514 267 564 515 407 442 325 558 M17553 GO_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATION_FORK.html The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 49/81 Gene Ontology CC GO:0005657 0.0839184282471183 0.0956703185933617 520 463 499 0.00793650793650794 257 1.83639559432018 -0.8384172920931 -1 1.57196342977998 517 556 257 404 499 502 532 484 328 447 567 559 M17069 GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX.html A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. 10/16 Gene Ontology CC GO:0005671 0.666416676571968 0.696544012764191 500 500.090909090909 500 0.0949867467017773 350 0.216102250227706 -0.225744437253216 -1 0.02850155720989 556 500 350 467 459 481 577 526 565 500 520 560 M17679 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE.html A cellular membrane associated with the pre-autophagosomal structure. 15/18 Gene Ontology CC GO:0034045 0.0839184282471183 0.0956703185933617 475 489.181818181818 504 0.00793650793650794 352 0.889875566384315 0.988803014551829 1 0.761736382280208 472 517 352 552 504 549 475 541 427 414 578 561 M17598 GO_MICROTUBULE_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_END.html Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. 14/27 Gene Ontology CC GO:1990752 0.557443745451391 0.58688977207815 565 478 506 0.0714285714285714 244 1.25170553927336 -0.361342383191806 -1 0.243304509153029 414 561 244 426 564 560 506 555 504 408 516 562 M17475 GO_CYTOPLASMIC_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_DYNEIN_COMPLEX.html Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. 8/29 Gene Ontology CC GO:0005868 0.146263615121281 0.164796041988499 550 469.909090909091 508 0.015688908076169 288 0.803234566803896 -0.803234566803896 -1 0.528249747196645 547 534 515 414 508 571 294 288 470 538 490 563 M17618 GO_LATERAL_ELEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_ELEMENT.html A proteinaceous core found between sister chromatids during meiotic prophase. 8/115 Gene Ontology CC GO:0000800 0.539218375823793 0.570820917996616 355 485.909090909091 511 0.0745573402415437 309 0.258581189202493 0.290931928517929 1 0.0528788654965058 354 522 545 489 511 468 309 518 577 560 492 564 M17207 GO_CCR4_NOT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR4_NOT_COMPLEX.html The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins. 9/18 Gene Ontology CC GO:0030014 0.900849582143098 0.911893272291962 515 510.272727272727 514 0.206349206349206 453 0.56189700880339 -0.574637850184293 -1 0.0189004013936883 578 562 467 477 528 453 514 516 533 513 472 565 M16990 GO_CONDENSED_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. 55/221 Gene Ontology CC GO:0000794 0.873630060954609 0.887269502164533 440 501.181818181818 515 0.171426093471255 356 0.794422166245101 0.87991205962092 1 0.0346549308476001 440 538 356 527 485 505 515 575 547 455 570 566 M17493 GO_HEMOGLOBIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_COMPLEX.html An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. 3/15 Gene Ontology CC GO:0005833 0.692053852342561 0.72073356153874 470 490.272727272727 515 0.111111111111111 398 0.926441097103228 0.552571765301644 1 0.110660321389823 470 398 519 422 560 533 471 416 515 541 548 567 M17657 GO_REPLISOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLISOME.html A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. 21/29 Gene Ontology CC GO:0030894 0.557443745451391 0.58688977207815 520 507.545454545455 516 0.0714285714285714 359 0.779785094119101 -0.727820739497245 -1 0.151572372008694 548 516 359 471 536 497 519 563 503 563 508 568 M17548 GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 8/20 Gene Ontology CC GO:0000780 0.924653397562808 0.934352559075705 510 513.636363636364 518 0.227841658589176 438 0.308159766298626 -0.319758328385441 -1 0.00762949963623479 518 508 533 476 563 463 522 438 571 549 509 569 M17469 GO_MISMATCH_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR_COMPLEX.html Any complex formed of proteins that act in mismatch repair. 6/12 Gene Ontology CC GO:0032300 0.6357681278647 0.665713728090212 505 506.909090909091 519 0.0960637674377608 331 0.1978035269175 -0.208475778080751 -1 0.0293541717487399 505 495 511 449 533 554 331 519 569 537 573 570 M17127 GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinase (CDK) complex found in the nucleus. 10/20 Gene Ontology CC GO:0019908 0.683304272935883 0.71290590208834 525 496.363636363636 521 0.0992509003152905 357 0.201872994661763 -0.276438632327033 -1 0.0249150611226508 566 577 357 521 462 524 549 376 549 505 474 571 M17478 GO_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. 10/24 Gene Ontology CC GO:0071010 0.874988955421771 0.887269502164533 575 502.363636363636 521 0.172240071519768 328 0.198663913204233 -0.19121785196757 -1 0.00866428961857101 572 521 328 468 531 420 510 574 575 539 488 572 M17804 GO_METHYLOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLOSOME.html A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. 6/17 Gene Ontology CC GO:0034709 0.934081566336537 0.942232365344709 575 505.454545454545 521 0.238095238095238 344 0.18004554711827 -0.20812576247005 -1 0.00390500035122575 533 397 574 344 521 488 554 514 546 574 515 573 M17483 GO_SPERM_PRINCIPAL_PIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PRINCIPAL_PIECE.html The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. 13/29 Gene Ontology CC GO:0097228 0.47417984118522 0.506609885776446 575 459.909090909091 523 0.0567613966708812 296 0.846847736715594 -0.671700219722212 -1 0.210043785384255 443 574 296 536 530 572 310 346 529 400 523 574 M17029 GO_KINESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_COMPLEX.html Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. 23/57 Gene Ontology CC GO:0005871 0.850621352955467 0.865597081000457 545 478.181818181818 524 0.158730158730159 241 0.901519183077514 -1.04508978065731 -1 0.0474587951346277 541 423 241 393 558 521 546 540 524 432 541 575 M17688 GO_WASH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_WASH_COMPLEX.html A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. 5/11 Gene Ontology CC GO:0071203 0.409067838222856 0.44194618783703 530 476.272727272727 530 0.0512456880095416 284 0.678773500518327 -0.835573358373134 -1 0.202163712425821 530 347 554 355 445 558 284 500 532 565 569 576 M17526 GO_U2_TYPE_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. 7/18 Gene Ontology CC GO:0071004 0.942728118163119 0.947646699649188 535 513.363636363636 535 0.248733289216112 447 0.187908371460775 0.209833005059227 1 0.00368293496445032 469 535 528 452 535 550 457 447 576 546 552 577 M17516 GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE.html The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. 6/14 Gene Ontology CC GO:0000940 0.999951914156276 0.999951914156276 580 540.363636363636 557 0.63 359 0.151248076638096 -0.154615831469384 -1 0 546 564 524 359 573 557 578 552 578 545 568 578 M17653 GO_TOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_COMPLEX.html A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. 7/17 Gene Ontology CC GO:0038201 0.995117842945788 0.99684248392143 565 545.727272727273 559 0.412698412698413 488 0.18501212021039 -0.162657893969748 -1 0.000210761912243802 511 563 549 488 577 575 516 528 559 562 575