Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M17016 GO_FILOPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a filopodium. 11/22 Gene Ontology CC GO:0031527 3.57138500739509e-08 6.25533495234656e-07 5 47.6363636363636 18 3.24671369579219e-09 2 2.66582257001475 2.66582257001475 1 23.0537374550894 25 183 96 16 41 18 5 2 11 124 3 2 M17128 GO_SITE_OF_POLARIZED_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_POLARIZED_GROWTH.html Any part of a cell where non-isotropic growth takes place. 108/272 Gene Ontology CC GO:0030427 1.0076281462208e-10 2.91204534257812e-09 20 24.3636363636364 21 9.16025587515412e-12 5 1.88603820273501 2.14946168173522 1 22.4414371175858 38 10 16 30 5 27 42 11 52 16 21 3 M17336 GO_CONTRACTILE_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_FIBER.html Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. 110/299 Gene Ontology CC GO:0043292 1.84913986376727e-09 4.27521136502992e-08 45 37.2727272727273 22 1.68103624120136e-10 5 2.02244635726913 2.10381215467218 1 20.7751381860958 6 43 21 105 16 5 8 45 96 43 22 4 M17408 GO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE.html The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. 361/1081 Gene Ontology CC GO:0045202 4.14229758422727e-09 9.05083401328011e-08 20 50.7272727272727 22 3.76572508366059e-10 2 1.67691858216453 1.80984573995279 1 16.4643549651755 16 109 22 51 149 2 26 22 127 19 15 5 M17433 GO_CELL_CELL_ADHERENS_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHERENS_JUNCTION.html An adherens junction which connects a cell to another cell. 33/93 Gene Ontology CC GO:0005913 1.4461816589211e-07 1.91333512779907e-06 10 30 22 1.31471068544238e-08 7 2.14048529397074 2.47899848528772 1 17.0619287246678 18 58 67 8 7 26 22 8 13 55 48 6 M17629 GO_NEURON_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a neuron projection. 18/74 Gene Ontology CC GO:0032589 4.93334398094268e-08 8.14706520281392e-07 15 38.9090909090909 23 4.4848582650631e-09 3 2.30776109001552 2.3111420784976 1 19.5881124962649 19 94 73 10 58 12 23 3 29 96 11 7 M16974 GO_FILOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM.html Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. 78/172 Gene Ontology CC GO:0030175 4.18796857894174e-07 3.45806548375475e-06 25 23.1818181818182 25 3.80724488742991e-08 9 1.98860541527014 2.13899718408533 1 15.1387463188894 23 11 31 9 39 11 13 25 36 32 25 8 M17676 GO_NEUROMUSCULAR_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION.html The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. 55/122 Gene Ontology CC GO:0031594 1.6995264569334e-06 8.38979355203159e-06 10 34.4545454545455 26 1.54502524530859e-07 6 1.93186309834186 2.14749112607804 1 13.6702070865841 7 89 38 15 99 9 6 26 30 36 24 9 M17263 GO_NEURON_SPINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_SPINE.html A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. 76/235 Gene Ontology CC GO:0044309 4.94545050870633e-06 1.76448789755078e-05 25 63.0909090909091 27 4.49587420525273e-07 13 1.87677978527416 2.1826608691858 1 12.4357454826251 27 167 78 21 153 14 17 24 72 108 13 10 M17697 GO_MICROBODY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_PART.html Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 54/112 Gene Ontology CC GO:0044438 7.12965921916976e-07 4.84816826903543e-06 20 118 28 6.4815104815619e-08 3 1.03245658176759 -1.02021637505803 -1 7.64863104823343 28 18 314 258 55 3 10 14 246 336 16 11 M17362 GO_ENDOPLASMIC_RETICULUM_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_LUMEN.html The volume enclosed by the membranes of the endoplasmic reticulum. 95/258 Gene Ontology CC GO:0005788 1.45742232849685e-09 3.71677065449675e-08 30 38.3636363636364 30 1.32492939042031e-10 5 2.12782448129419 2.38721718946874 1 22.0379290125727 30 45 18 13 112 32 71 9 63 24 5 12 M17227 GO_ACTIN_FILAMENT_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE.html An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. 46/106 Gene Ontology CC GO:0032432 1.44942759612019e-06 7.48008170140599e-06 20 45.1818181818182 32 1.31766231913501e-07 19 2.51839450476312 2.82717786010537 1 17.9955926412787 22 105 39 46 93 19 28 20 31 62 32 13 M17803 GO_FILAMENTOUS_ACTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMENTOUS_ACTIN.html A two-stranded helical polymer of the protein actin. 19/46 Gene Ontology CC GO:0031941 1.00209537613134e-07 1.48515673693311e-06 5 97.1818181818182 33 9.109958379787e-09 4 2.71187017559775 3.56084030583375 1 22.0323722324659 171 25 33 5 4 303 272 75 8 28 145 14 M17296 GO_COSTAMERE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COSTAMERE.html Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. 11/29 Gene Ontology CC GO:0043034 2.55367634360345e-07 2.82393609265521e-06 20 59.8181818181818 34 2.32152421820413e-08 3 2.23498868772332 2.23498868772332 1 17.2884981094017 31 162 121 34 17 47 40 16 3 170 17 15 M17334 GO_LEADING_EDGE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEADING_EDGE_MEMBRANE.html The portion of the plasma membrane surrounding the leading edge of a motile cell. 82/233 Gene Ontology CC GO:0031256 4.42183980469206e-07 3.59975127762255e-06 35 60.9090909090909 34 4.01985517586356e-08 9 1.74209335332318 1.89823204727344 1 13.2197625577499 34 191 85 19 40 33 18 12 128 101 9 16 M17831 GO_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE.html A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. 252/725 Gene Ontology CC GO:0030425 8.61584917860453e-07 5.37751193986866e-06 20 39.9090909090909 34 7.83259322984288e-08 5 1.75936288782446 1.97971127306401 1 12.923316522049 43 5 34 25 69 30 39 19 110 46 19 17 M17462 GO_NEURON_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION.html A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 512/1429 Gene Ontology CC GO:0043005 1.79363734535759e-07 2.1395696146111e-06 5 88.9090909090909 35 1.79363749012868e-08 2 1.67990280193657 1.827739952076 1 13.2769421688836 69 3 507 2 13 35 86 79 146 15 23 18 M17664 GO_CELL_PROJECTION_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_PART.html Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. 498/1408 Gene Ontology CC GO:0044463 1.45651809036608e-07 1.91333512779907e-06 75 53.8181818181818 35 1.32410744254128e-08 8 1.58965975147186 1.69290094325676 1 12.6712673153893 75 37 32 24 8 25 72 74 175 35 35 19 M17494 GO_DENDRITE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MEMBRANE.html The portion of the plasma membrane surrounding a dendrite. 12/37 Gene Ontology CC GO:0032590 4.22789824149763e-09 9.05083401328011e-08 5 60.5454545454545 37 3.84354386329334e-10 1 2.03607978629254 2.03607978629254 1 19.9906785672461 17 153 106 37 137 1 3 1 77 133 1 20 M17824 GO_SYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_MEMBRANE.html A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 103/356 Gene Ontology CC GO:0097060 1.28641867024737e-06 7.10142493132185e-06 10 56.6363636363636 37 1.16947220223908e-07 10 1.68583906972202 1.94821616307245 1 12.099452446829 10 179 60 93 86 10 15 27 86 37 20 21 M17302 GO_BASEMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE.html A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. 53/132 Gene Ontology CC GO:0005604 8.15353024543803e-14 3.92728373488598e-12 15 41.0909090909091 38 7.41230022312573e-15 5 2.2390585226974 2.32410964165054 1 35.6000946814049 5 15 9 12 166 42 54 38 48 20 43 22 M17008 GO_CELL_CELL_CONTACT_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_CONTACT_ZONE.html Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. 48/126 Gene Ontology CC GO:0044291 4.00063139436285e-07 3.40053668520842e-06 60 43.4545454545455 41 3.63693829260489e-08 17 1.93160853949264 2.00636992273533 1 14.7244613732665 37 17 71 48 37 24 29 59 59 56 41 23 M17077 GO_BASAL_LAMINA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_LAMINA.html A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. 18/46 Gene Ontology CC GO:0005605 1.83919100573446e-09 4.27521136502992e-08 75 60.3636363636364 43 1.67199182479274e-10 11 2.23868657118474 2.42823406894094 1 22.996418528942 11 24 20 43 186 71 92 80 28 34 75 24 M17398 GO_EXTRACELLULAR_MATRIX_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_COMPONENT.html Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). 65/171 Gene Ontology CC GO:0044420 6.27287519088801e-16 3.62572186033327e-14 45 47.2727272727273 43 5.70261380989818e-17 3 2.32189724491523 2.4366919526927 1 43.5028475559373 3 13 8 42 180 44 70 43 51 17 49 25 M17217 GO_INTERMEDIATE_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT.html A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. 48/224 Gene Ontology CC GO:0005882 1.47899178293123e-09 3.71677065449675e-08 40 56.2727272727273 44 1.34453798538683e-10 11 2.68578127266334 2.87265461704458 1 27.8167008522163 62 125 19 44 101 38 11 100 38 47 34 26 M17678 GO_SOMATODENDRITIC_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATODENDRITIC_COMPARTMENT.html The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. 373/1027 Gene Ontology CC GO:0036477 1.190970096895e-10 3.27800340954909e-09 30 55.8181818181818 44 1.08270008814497e-11 17 1.77030451560864 1.95038171310078 1 20.9374836458676 76 39 17 31 44 54 95 64 136 29 29 27 M17343 GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX.html A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. 133/408 Gene Ontology CC GO:0005578 1.76517723319055e-33 5.10136220392069e-31 5 40.7272727272727 45 1.60470657562778e-34 1 2.2230641843325 2.35207158285047 1 93.8729150581354 1 8 2 66 103 43 77 51 49 3 45 28 M17150 GO_NEURON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PART.html Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 647/1803 Gene Ontology CC GO:0097458 1.09505870040963e-07 1.58235982209191e-06 35 102.727272727273 46 1.09505875437154e-08 12 1.6614418602131 1.79554209125779 1 13.4344847300949 86 35 457 29 32 46 107 127 162 12 37 29 M17655 GO_ACTIN_BASED_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BASED_CELL_PROJECTION.html A cell projection supported by an assembly of actin filaments, and which lacks microtubules. 120/302 Gene Ontology CC GO:0098858 8.37037656544349e-09 1.5606702112343e-07 30 53.7272727272727 47 7.609433270264e-10 26 1.99912771871383 2.10998560742856 1 18.968469635113 47 102 26 45 28 57 35 77 69 26 79 30 M17195 GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION.html Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. 17/43 Gene Ontology CC GO:0098636 8.32626481126522e-08 1.26646870023982e-06 90 53.9090909090909 50 7.56933193307867e-09 3 2.61850569138166 3.24670149233214 1 21.5263486248097 50 79 88 18 3 72 90 4 19 143 27 31 M17284 GO_ACTOMYOSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN.html Any complex of actin, myosin, and accessory proteins. 47/116 Gene Ontology CC GO:0042641 1.10432439302544e-06 6.44746968857276e-06 30 60.3636363636364 50 1.00393177032611e-07 14 2.44346602515987 2.73974426058728 1 17.6799330230337 14 138 68 96 80 20 27 23 50 120 28 32 M16979 GO_I_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_BAND.html A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. 65/198 Gene Ontology CC GO:0031674 3.96560252619594e-07 3.40053668520842e-06 90 62.7272727272727 51 3.6050938554677e-08 29 2.19751731103449 2.44527490421545 1 16.7514577188236 29 88 45 95 36 51 73 46 89 87 51 33 M17775 GO_SYNAPSE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_PART.html Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 288/866 Gene Ontology CC GO:0044456 2.4949395544868e-06 1.05260953466669e-05 40 63.7272727272727 51 2.2681294399191e-07 7 1.59242041125364 1.75917731710325 1 11.049564470031 36 121 54 69 122 7 51 40 145 38 18 34 M17656 GO_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION.html A prolongation or process extending from a cell, e.g. a flagellum or axon. 902/2503 Gene Ontology CC GO:0042995 3.01555375316906e-07 2.88634899728623e-06 30 105.727272727273 52 3.01555416237954e-08 18 1.58230471106162 1.69096933399084 1 12.2187953652216 67 52 550 118 29 28 56 32 182 18 31 35 M17725 GO_ACTIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT.html A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. 51/112 Gene Ontology CC GO:0005884 3.70611025033527e-08 6.30038742556996e-07 145 63.8181818181818 52 3.36919119342566e-09 1 1.96369443806714 2.39697715956514 1 16.9732798998047 81 16 48 6 1 143 106 52 41 67 141 36 M17139 GO_MYOFILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFILAMENT.html Any of the smallest contractile units of a myofibril (striated muscle fiber). 16/34 Gene Ontology CC GO:0036379 3.23221242878816e-06 1.28842674747556e-05 20 57.3636363636364 53 2.93837925229447e-07 12 2.73826663783652 2.960660203991 1 18.6653072414736 20 62 63 53 131 37 12 78 18 105 52 37 M17058 GO_INTERCALATED_DISC http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCALATED_DISC.html A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. 41/108 Gene Ontology CC GO:0014704 3.00203309768909e-07 2.88634899728623e-06 80 53.1818181818182 54 2.72912137030431e-08 20 1.96170624548377 2.06538694198895 1 15.1485911875177 54 20 77 27 24 40 31 102 60 78 72 38 M17561 GO_ANCHORING_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORING_JUNCTION.html A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. 349/772 Gene Ontology CC GO:0070161 1.10054725955105e-06 6.44746968857276e-06 35 60.8181818181818 54 1.00049800918076e-07 8 1.76414083139015 1.91867118980104 1 12.7646103453635 33 141 66 32 79 34 66 18 138 54 8 39 M17182 GO_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON.html The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. 238/668 Gene Ontology CC GO:0030424 1.81382199162533e-07 2.1395696146111e-06 15 57.4545454545455 55 1.64892921924412e-08 12 1.69515902556635 1.88856063126607 1 13.3975181923819 82 55 35 14 12 59 118 72 108 27 50 40 M17465 GO_APICOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICOLATERAL_PLASMA_MEMBRANE.html The apical end of the lateral plasma membrane of epithelial cells. 15/27 Gene Ontology CC GO:0016327 2.89484719712067e-06 1.17008509086416e-05 55 65.0909090909091 55 2.63168273298397e-07 15 2.47428087384985 -2.70996454380028 -1 17.0101746118121 42 107 55 103 126 16 99 30 15 70 53 41 M17691 GO_PERIKARYON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIKARYON.html The portion of the cell soma (cell body) that excludes the nucleus. 80/202 Gene Ontology CC GO:0043204 2.58942236869769e-07 2.82393609265521e-06 45 80.8181818181818 55 2.35402061225035e-08 18 1.82302821198142 2.04297514172845 1 14.1018251885454 44 220 90 88 18 55 41 41 143 123 26 42 M16984 GO_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX.html A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants). 172/559 Gene Ontology CC GO:0031012 5.47470060427981e-36 3.16437694927373e-33 5 52.8181818181818 58 4.97700054934534e-37 1 2.20731663114481 2.41621084151927 1 100 4 40 1 73 117 67 104 53 58 4 60 43 M17765 GO_TERMINAL_BOUTON http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINAL_BOUTON.html Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. 38/105 Gene Ontology CC GO:0043195 2.23079127563634e-07 2.52823011238785e-06 60 57.7272727272727 59 2.02799227439793e-08 2 1.85041829744919 1.89703672949604 1 14.4376099649002 72 59 109 28 15 13 48 60 111 118 2 44 M17628 GO_PLASMA_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_REGION.html A membrane that is a (regional) part of the plasma membrane. 437/1317 Gene Ontology CC GO:0098590 5.37365554504953e-31 1.03532430167954e-28 5 68.7272727272727 61 4.88514140459054e-32 1 1.80909331081347 1.86030317517057 1 70.5733849214859 61 38 3 1 38 115 119 151 133 5 92 45 M17419 GO_CATION_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_COMPLEX.html An ion channel complex through which cations pass. 62/225 Gene Ontology CC GO:0034703 3.04614686564809e-07 2.88634899728623e-06 65 66 64 2.76922480674672e-08 3 1.92266317733129 2.04901362859751 1 14.8470947316929 64 48 30 3 25 87 114 154 105 31 65 46 M17620 GO_INTERMEDIATE_FILAMENT_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_CYTOSKELETON.html Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. 85/303 Gene Ontology CC GO:0045111 5.94662699185723e-07 4.43824007690504e-06 50 75.2727272727273 64 5.40602599930765e-08 46 2.20234239923128 2.44350038440945 1 16.4331505820402 97 145 46 80 49 64 60 82 61 85 59 47 M17084 GO_NEURON_PROJECTION_TERMINUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_TERMINUS.html The specialized, terminal region of a neuron projection such as an axon or a dendrite. 80/226 Gene Ontology CC GO:0044306 3.84996763305345e-07 3.38754821550704e-06 60 64.1818181818182 65 3.49997118799299e-08 14 1.82466347078527 2.07185560159628 1 13.9134569707216 56 122 82 65 34 36 78 56 95 68 14 48 M17447 GO_LAMELLIPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a lamellipodium. 19/37 Gene Ontology CC GO:0031258 4.14839524364162e-07 3.45806548375475e-06 5 81.2727272727273 65 3.77126911443401e-08 4 1.92557738229003 1.92557738229003 1 14.6589299618863 35 267 148 97 65 29 4 5 75 159 10 49 M17307 GO_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION.html A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. 635/1673 Gene Ontology CC GO:0030054 1.92128663186167e-11 6.53237454832968e-10 55 102.454545454545 67 1.92128663187828e-12 9 1.7527733955274 1.85144004524261 1 22.4417865070178 52 53 486 75 71 45 85 67 154 9 30 50 M17310 GO_COMPLEX_OF_COLLAGEN_TRIMERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEX_OF_COLLAGEN_TRIMERS.html A complex of collagen trimers such as a fibril or collagen network. 12/30 Gene Ontology CC GO:0098644 0.000144780664214022 0.000318187163177585 50 91.8181818181818 67 1.31627448199597e-05 8 2.55986121885254 2.55986121885254 1 12.479791105809 8 133 64 147 288 48 46 99 39 71 67 51 M17365 GO_BANDED_COLLAGEN_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BANDED_COLLAGEN_FIBRIL.html A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). 12/23 Gene Ontology CC GO:0098643 0.000144780664214022 0.000318187163177585 50 92.5454545454545 68 1.31627448199597e-05 9 2.55986121885254 2.55986121885254 1 12.479791105809 9 134 65 148 289 49 47 97 40 72 68 52 M17635 GO_CELL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_BODY.html The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. 297/774 Gene Ontology CC GO:0044297 2.47698727498333e-08 4.47405826543864e-07 105 75.6363636363636 68 2.25180663897438e-09 22 1.75503694798282 1.97725948745073 1 15.5334474745891 102 68 27 60 22 102 131 114 120 48 38 53 M17740 GO_CELL_LEADING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_LEADING_EDGE.html The area of a motile cell closest to the direction of movement. 234/544 Gene Ontology CC GO:0031252 1.13342512603573e-06 6.4863338895906e-06 65 81.9090909090909 68 1.03038700906283e-07 28 1.6918010242699 1.89572773442842 1 12.2350334945946 60 176 62 47 83 68 68 28 141 104 64 54 M17813 GO_CENTRIOLAR_SATELLITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLAR_SATELLITE.html A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. 10/33 Gene Ontology CC GO:0034451 3.85258713718044e-06 1.43276129898761e-05 15 92.8181818181818 68 3.50235807614091e-07 8 1.84925121316623 -1.84925121316623 -1 12.486488272162 40 140 164 173 142 8 14 57 68 203 12 55 M17160 GO_MICROBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY.html Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 81/169 Gene Ontology CC GO:0042579 1.86891657897408e-06 8.86053562711657e-06 310 150.545454545455 69 1.69901651512244e-07 6 1.04875285929676 -0.967978724602819 -1 7.38650118993462 41 56 307 307 106 6 34 69 323 371 36 56 M17531 GO_LAMELLIPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM.html A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. 129/281 Gene Ontology CC GO:0030027 9.00071805378139e-07 5.47622635272173e-06 60 71.5454545454545 69 8.18247430562654e-08 31 1.85027324513519 2.05932120812205 1 13.5707182224926 57 136 58 54 73 73 57 31 81 69 98 57 M17177 GO_POSTSYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPSE.html The part of a synapse that is part of the post-synaptic cell. 184/552 Gene Ontology CC GO:0098794 5.84773271243877e-06 1.99999379159148e-05 85 72.9090909090909 70 5.31613477829356e-07 15 1.62702282158593 1.77486219046575 1 10.6574252386955 15 177 70 82 159 17 20 35 112 82 33 58 M17845 GO_COLLAGEN_TRIMER http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_TRIMER.html A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. 29/89 Gene Ontology CC GO:0005581 2.77353964656745e-12 1.06873727714399e-10 70 85.7272727272727 70 2.52139967870086e-13 2 2.54051007665978 2.5674186131364 1 35.3119022010724 2 92 12 157 258 70 64 105 66 21 96 59 M17511 GO_MEMBRANE_MICRODOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_MICRODOMAIN.html A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. 188/491 Gene Ontology CC GO:0098857 8.27453079166083e-09 1.5606702112343e-07 75 84.5454545454545 73 7.52230074798418e-10 25 1.63427908614607 1.87410005860405 1 15.5066496801547 63 41 25 59 74 116 136 98 206 39 73 60 M17414 GO_POSTSYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE.html A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. 73/268 Gene Ontology CC GO:0045211 3.3628682517441e-06 1.33132729418362e-05 75 81.5454545454545 74 3.0571576292331e-07 13 1.79466053259347 2.03269778995808 1 12.1976591046599 13 204 81 139 132 52 30 39 74 75 58 61 M17240 GO_POTASSIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_COMPLEX.html An ion channel complex through which potassium ions pass. 31/123 Gene Ontology CC GO:0034705 3.3951867058436e-07 3.066277993715e-06 115 92.8181818181818 76 3.08653384528324e-08 22 1.76544274075492 1.94148548401107 1 13.5683826779538 111 22 83 52 30 124 145 262 67 49 76 62 M17513 GO_TRANSPORTER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_COMPLEX.html A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. 102/394 Gene Ontology CC GO:1990351 7.90254735660753e-07 5.19053678649904e-06 45 130.909090909091 77 7.18413654114263e-08 4 1.7891657684522 1.91829021243751 1 13.1805636087763 173 44 47 4 61 178 188 505 119 44 77 63 M17671 GO_KERATIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATIN_FILAMENT.html A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. 20/107 Gene Ontology CC GO:0045095 9.24254431219256e-07 5.56478188796594e-06 210 123 77 8.40231654102943e-08 17 2.6007823475722 2.95094473647157 1 19.050024770803 210 77 42 50 75 271 151 209 17 59 192 64 M17213 GO_MYOSIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_FILAMENT.html A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. 9/29 Gene Ontology CC GO:0032982 7.30059812293192e-06 2.37064366014306e-05 40 116.909090909091 79 7.30062210747263e-07 10 3.66480412963493 3.66480412963493 1 23.6282150971016 39 97 470 79 175 66 61 58 10 138 93 65 M17091 GO_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. 239/581 Gene Ontology CC GO:0015629 2.94509736709033e-07 2.88634899728623e-06 80 77.3636363636364 80 2.67736160122262e-08 23 1.81057843144199 2.05659687975285 1 13.9815594334508 77 84 52 113 23 79 102 81 80 73 87 66 M17547 GO_CELL_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION.html A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. 241/593 Gene Ontology CC GO:0005911 1.26953265033201e-20 8.15322079879894e-19 10 79.7272727272727 80 1.15412059121092e-21 4 1.87588449886823 1.86765226546279 1 47.3008128690638 80 4 7 89 27 60 87 290 115 8 110 67 M17384 GO_CELL_SUBSTRATE_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION.html A cell junction that forms a connection between a cell and the extracellular matrix. 303/642 Gene Ontology CC GO:0030055 4.68909437588534e-07 3.71273499898867e-06 135 81.5454545454545 84 4.2628139775657e-08 4 1.77689062765079 1.93707301810275 1 13.4505751944358 26 243 125 84 94 15 36 6 132 132 4 68 M17355 GO_CORTICAL_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_ACTIN_CYTOSKELETON.html The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. 43/106 Gene Ontology CC GO:0030864 1.2620246789306e-06 7.08204140215427e-06 110 102.727272727273 85 1.14729582080781e-07 45 1.94860212461307 2.26921640525588 1 13.9885561688934 109 49 51 55 85 198 160 108 45 65 205 69 M17744 GO_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_COMPLEX.html An ion channel complex through which calcium ions pass. 29/87 Gene Ontology CC GO:0034704 1.36914232441401e-05 3.9371356393597e-05 45 118.636363636364 89 1.24468258652116e-06 38 1.91528566430357 2.13282672047722 1 11.7602766927209 48 259 115 38 197 69 89 42 235 171 42 70 M17810 GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the plasma membrane. 221/687 Gene Ontology CC GO:0098797 2.48535529968358e-12 1.02609668801222e-10 15 90.9090909090909 90 2.2594139088058e-13 6 1.86053363512803 2.06306696404613 1 25.9064083467923 85 6 11 90 56 174 217 141 101 14 105 71 M17754 GO_PROTEIN_LIPID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX.html A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. 17/64 Gene Ontology CC GO:0032994 1.42182267163026e-06 7.40372526308368e-06 510 220.181818181818 91 1.29256690048269e-07 27 1.91757232190108 1.76543730511858 1 13.7142324180027 509 27 79 67 91 483 417 228 33 45 443 72 M17141 GO_CELL_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a cell surface projection. 160/464 Gene Ontology CC GO:0031253 2.86273744144134e-07 2.88634899728623e-06 95 92.6363636363636 92 2.6024889217759e-08 21 1.70813875471716 1.83101500083018 1 13.1905048127496 92 144 40 63 21 113 100 106 194 58 88 73 M17595 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE.html A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. 25/42 Gene Ontology CC GO:0030140 1.85203478566759e-05 5.09793048961793e-05 205 154.727272727273 93 1.68368216082704e-06 31 0.946273035410464 -0.962009538785036 -1 5.66230622591929 68 202 288 72 204 31 59 93 346 277 62 74 M17612 GO_CELL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX.html The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 156/408 Gene Ontology CC GO:0005938 1.7279670778193e-07 2.13936413097786e-06 70 126.272727272727 94 1.57087928503699e-08 10 1.76240924585775 1.95601073122417 1 13.9291259953921 152 70 50 68 10 243 195 229 94 51 227 75 M17755 GO_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REGION.html A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane. 543/1581 Gene Ontology CC GO:0098589 1.55418845878691e-14 8.16655390162577e-13 80 132.636363636364 94 1.55418845878692e-15 2 1.76036207707148 1.84549012778318 1 29.6627160578737 79 2 567 74 42 132 161 155 147 6 94 76 M17599 GO_SUPRAMOLECULAR_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPRAMOLECULAR_FIBER.html A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. 288/821 Gene Ontology CC GO:0099512 1.31312551470041e-07 1.80711082737342e-06 120 93.0909090909091 95 1.19375053916148e-08 6 1.70368086013368 2.01178841258044 1 13.6390482047689 116 151 49 163 6 119 74 44 126 95 81 77 M17648 GO_LAMELLAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLAR_BODY.html A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. 10/26 Gene Ontology CC GO:0042599 0.000591029876945569 0.00113493444808817 65 140.090909090909 95 5.37444288030382e-05 63 1.79497508370752 -1.79497508370752 -1 7.36892072860682 66 272 169 202 290 63 76 92 64 152 95 78 M17568 GO_PRESYNAPTIC_ACTIVE_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_ACTIVE_ZONE.html A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. 9/44 Gene Ontology CC GO:0048786 2.29907672722649e-06 1.00671693055827e-05 155 123.909090909091 96 2.29907910581916e-07 29 1.87800329822779 1.98292928696862 1 13.0818632090747 155 29 537 107 123 135 96 36 35 66 44 79 M17375 GO_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_COMPLEX.html A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. 18/74 Gene Ontology CC GO:0016459 6.69852419046175e-07 4.6791602520711e-06 75 102.909090909091 97 6.08956930001669e-08 20 2.64645715330954 2.81444783136147 1 19.6622968024002 73 78 97 101 53 92 154 146 20 185 133 80 M17632 GO_SARCOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOLEMMA.html The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. 69/199 Gene Ontology CC GO:0042383 4.81056904740994e-07 3.75744447216615e-06 45 95.6363636363636 97 4.3732455448182e-08 14 1.6495652318433 1.7365862019386 1 12.4748028274795 74 14 43 120 45 97 128 177 193 33 128 81 M17709 GO_MYOSIN_II_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_II_COMPLEX.html A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. 8/31 Gene Ontology CC GO:0016460 1.71233232235515e-06 8.38979355203159e-06 55 149.727272727273 98 1.71233364179347e-07 2 2.22238166841317 2.22238166841317 1 15.7259681989568 53 98 558 176 243 41 2 128 46 236 66 82 M17559 GO_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_COMPLEX.html Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 124/450 Gene Ontology CC GO:0043235 1.6108784170208e-06 8.09641500033063e-06 100 110.090909090909 99 1.46443599685029e-07 9 1.8236723389534 2.00043833285905 1 12.9439280109072 99 9 57 119 98 235 245 87 104 50 108 83 M17212 GO_CORTICAL_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON.html The portion of the cytoskeleton that lies just beneath the plasma membrane. 51/134 Gene Ontology CC GO:0030863 6.17826004765455e-07 4.45663350390702e-06 60 139.545454545455 100 5.61660162063275e-08 51 1.81502635565396 2.1691926878085 1 13.5385819550053 163 90 56 58 51 280 210 181 73 100 273 84 M17271 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. 11/48 Gene Ontology CC GO:0034364 1.71279522342513e-06 8.38979355203159e-06 465 226.181818181818 100 1.55708777901073e-07 12 2.34874972839594 1.96376452850217 1 16.6201710841452 465 63 76 23 100 547 476 291 12 60 375 85 M17076 GO_MICROBODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_MEMBRANE.html The lipid bilayer surrounding a microbody. 36/69 Gene Ontology CC GO:0031903 2.19615280270771e-06 9.76443323050044e-06 75 168.545454545455 101 1.9965045409301e-07 49 0.932417971193928 -0.88570675542511 -1 6.51230613580342 101 74 343 285 116 50 75 49 349 313 99 86 M17009 GO_MUSCLE_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_MYOSIN_COMPLEX.html A filament of myosin found in a muscle cell of any type. 7/27 Gene Ontology CC GO:0005859 1.55710244788677e-05 4.390269340871e-05 75 142.363636363636 102 1.55711335855052e-06 24 2.22238166841317 2.22238166841317 1 13.499347457151 71 100 434 175 201 58 24 136 43 222 102 87 M17801 GO_PLASMA_MEMBRANE_RAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RAFT.html A membrane raft that is part of the plasma membrane. 63/155 Gene Ontology CC GO:0044853 7.47523961133729e-05 0.000175637743713535 130 120.090909090909 102 6.79590329074278e-06 24 1.51791653631187 1.59368362420152 1 7.94617054646031 24 168 102 130 239 75 33 73 270 127 80 88 M17327 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE.html A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. 29/77 Gene Ontology CC GO:0045334 4.94195271274926e-07 3.80859822395876e-06 160 124.181818181818 103 4.49268529352843e-08 23 1.68662976889859 1.66389725903794 1 12.7412954327229 157 23 103 56 46 224 123 345 83 116 90 89 M17763 GO_AXON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_PART.html A part of an axon, a cell projection of a neuron. 133/371 Gene Ontology CC GO:0033267 8.22416536813829e-08 1.26646870023982e-06 105 100.090909090909 104 7.47651425052613e-09 2 1.62987291909568 1.78114644601686 1 13.3989445696025 105 71 92 57 2 106 182 169 130 83 104 90 M17364 GO_LATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_PLASMA_MEMBRANE.html The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. 40/93 Gene Ontology CC GO:0016328 1.93285931146983e-06 9.0828673335737e-06 455 198.454545454545 108 1.75714637238981e-07 19 1.94296256323586 -1.940615659652 -1 13.6553841241886 455 19 37 91 108 337 455 162 65 74 380 91 M17573 GO_PODOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PODOSOME.html An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. 12/34 Gene Ontology CC GO:0002102 1.35817287675768e-06 7.27549828627935e-06 115 121.545454545455 112 1.23470337748019e-07 7 2.21575333503585 2.48041481628801 1 15.8702207166937 114 81 112 33 88 197 347 124 7 178 56 92 M17257 GO_DENDRITIC_SHAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SHAFT.html Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. 20/67 Gene Ontology CC GO:0043198 8.65239810394093e-07 5.37751193986866e-06 30 125.181818181818 114 7.86581955168324e-08 26 1.58341301588414 1.79136829929343 1 11.6308850896798 134 26 141 26 70 114 83 410 54 173 146 93 M17654 GO_WNT_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALOSOME.html A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. 10/21 Gene Ontology CC GO:1990909 6.24545525634028e-07 4.45663350390702e-06 10 102.727272727273 114 5.67768820847987e-08 6 1.5639778825391 1.5639778825391 1 11.6659698401873 32 210 130 132 146 21 16 7 316 114 6 94 M17215 GO_NEURONAL_POSTSYNAPTIC_DENSITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_POSTSYNAPTIC_DENSITY.html A postsynaptic density that is part of a neuron. 43/96 Gene Ontology CC GO:0097481 4.26121760703059e-06 1.55885049168587e-05 140 122.181818181818 115 3.87384169152563e-07 84 1.5534279684973 1.80918654279803 1 10.4097131082128 98 139 139 115 148 110 171 113 84 141 86 95 M17746 GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. 7/34 Gene Ontology CC GO:0034361 0.000441591389827773 0.000877112794915646 115 167.909090909091 121 4.41679165707453e-05 22 1.67439072848658 1.82241592742253 1 7.13510262200955 112 30 566 61 281 210 205 159 22 80 121 96 M17085 GO_CYTOPLASMIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_REGION.html Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\ 188/475 Gene Ontology CC GO:0099568 1.65002293955957e-07 2.11936279792318e-06 80 138.818181818182 122 1.5000209666482e-08 9 1.70779903334343 1.87762150120531 1 13.5072280838307 154 111 69 76 9 265 197 223 122 76 225 97 M17733 GO_GOLGI_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LUMEN.html The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. 35/156 Gene Ontology CC GO:0005796 5.3444002998266e-09 1.06519426665509e-07 25 223.090909090909 122 4.85854573891783e-10 21 2.20780506455957 2.03149988560022 1 21.4590027634664 405 21 24 122 82 559 488 260 32 25 436 98 M17840 GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE.html A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood. 7/34 Gene Ontology CC GO:0034385 0.000441591389827773 0.000877112794915646 115 169.909090909091 122 4.41679165707453e-05 23 1.67439072848658 1.82241592742253 1 7.13510262200955 113 31 578 62 282 211 206 160 23 81 122 99 M17158 GO_APICAL_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_COMPLEX.html A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. 77/174 Gene Ontology CC GO:0043296 5.09178555883537e-08 8.17514459168567e-07 505 219.636363636364 123 4.62889606971099e-09 28 1.8624448280026 -2.04558029614435 -1 15.8044202457794 502 103 28 123 57 391 565 210 117 42 278 100 M17474 GO_EXTRACELLULAR_SPACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_SPACE.html That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. 587/2139 Gene Ontology CC GO:0005615 8.24875780955355e-28 9.5355640278439e-26 125 139.090909090909 124 8.24875780955352e-29 1 2.01093256305601 2.09385713191307 1 70.1377794438442 59 1 514 146 47 189 202 125 121 2 124 101 M17690 GO_CORNIFIED_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORNIFIED_ENVELOPE.html A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). 7/67 Gene Ontology CC GO:0001533 2.34509200868896e-06 1.01768825463012e-05 90 162.636363636364 124 2.34509448344807e-07 54 1.30728240679267 -1.49408855446722 -1 9.09773660842753 88 154 555 149 124 91 246 54 102 169 57 102 M17010 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX.html A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. 15/54 Gene Ontology CC GO:0005891 5.61052518945006e-06 1.95354431295309e-05 150 129.181818181818 129 5.10049045243612e-07 13 2.61078102291568 2.94529193458817 1 17.1384400844271 87 268 98 64 254 129 150 13 150 162 46 103 M17056 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. 12/18 Gene Ontology CC GO:0012510 2.32742177031795e-05 6.19930775688376e-05 130 181.363636363636 129 2.11586035719949e-06 98 0.821321334673183 -0.824656700599956 -1 4.81736179008103 123 128 255 98 212 101 129 185 285 366 113 104 M17154 GO_ROUGH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM.html The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. 47/110 Gene Ontology CC GO:0005791 8.97874838143305e-07 5.47622635272173e-06 170 158.818181818182 129 8.16250185989651e-08 72 2.27184767895513 2.63900502079974 1 16.6627306538162 166 187 91 121 72 276 174 334 78 119 129 105 M17686 GO_RUFFLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE.html Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. 112/276 Gene Ontology CC GO:0001726 1.17504850795707e-06 6.65860821175673e-06 155 136.272727272727 129 1.06822648687834e-07 36 1.63070756736208 1.68041490060194 1 11.7673300588025 153 226 86 36 84 164 91 123 207 129 200 106 M17802 GO_MICROBODY_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_LUMEN.html The volume enclosed by the membranes of a microbody. 23/53 Gene Ontology CC GO:0031907 2.67168773747097e-06 1.11901124076683e-05 10 111.181818181818 129 2.42880998362134e-07 4 1.15644164719949 -1.15644164719949 -1 7.98154604870782 21 147 221 212 143 4 7 10 129 322 7 107 M16988 GO_CYTOCHROME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX.html A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 7/29 Gene Ontology CC GO:0070069 1.97375223282071e-07 2.28165758114074e-06 155 161 130 1.97375240812713e-08 1 2.61214465616543 3.55389468427202 1 20.5431425236727 151 130 430 7 14 270 415 21 1 221 111 108 M17060 GO_EXCITATORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. 106/315 Gene Ontology CC GO:0060076 6.31206021905607e-05 0.0001520154502756 15 114.090909090909 132 5.73840120618587e-06 12 1.44911935695044 1.5168355387454 1 7.71274022563344 12 227 132 154 264 22 19 33 210 142 40 109 M17105 GO_CELL_CORTEX_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_PART.html Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 75/185 Gene Ontology CC GO:0044448 5.93421674932457e-07 4.43824007690504e-06 195 179.181818181818 132 5.39474395454884e-08 48 1.71790223914322 2.00874230958275 1 12.818418318239 194 132 59 114 48 361 270 241 107 94 351 110 M17741 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated endocytic vesicle. 25/55 Gene Ontology CC GO:0030669 8.19399284141364e-07 5.32149198015403e-06 135 134.090909090909 133 7.4490871757295e-08 50 1.47577667371347 1.51291696096564 1 10.849603533813 133 50 122 78 66 214 105 297 134 136 140 111 M17606 GO_APICAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the apical end of the cell. 170/492 Gene Ontology CC GO:0016324 1.83457713933417e-25 1.76730931089191e-23 425 241.636363636364 135 1.66779739939469e-26 4 2.08332606215942 2.0428709667775 1 66.0763130918099 425 42 4 135 78 449 573 373 87 10 482 112 M17142 GO_APICAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PART_OF_CELL.html The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. 212/594 Gene Ontology CC GO:0045177 5.31473814112929e-25 4.38845520796104e-23 270 217.727272727273 136 4.83158012829936e-26 5 2.00846788033638 1.90491981851798 1 62.5961529829618 269 7 5 136 62 532 426 464 99 11 384 113 M17035 GO_BASOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASOLATERAL_PLASMA_MEMBRANE.html The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 114/324 Gene Ontology CC GO:0016323 9.30698493841592e-12 3.36214830900275e-10 205 152.727272727273 137 8.46089539859574e-13 13 1.91740811515498 1.79835221038858 1 25.3206888882194 192 72 13 104 63 201 201 513 137 22 162 114 M17092 GO_GLYCOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_COMPLEX.html A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. 9/23 Gene Ontology CC GO:0090665 1.65037662074509e-05 4.63066838247895e-05 110 147.545454545455 137 1.65038887771666e-06 5 2.05908499424462 2.17197126518327 1 12.4409841777155 51 163 448 171 203 107 158 110 5 137 70 115 M17827 GO_ANCHORED_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 56/186 Gene Ontology CC GO:0031225 3.5124967661917e-11 1.127901739366e-09 110 144.818181818182 137 3.19317887840708e-12 14 1.87797497765914 1.68526734207146 1 23.4238600521237 108 57 14 137 95 230 279 308 151 23 191 116 M17544 GO_SARCOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASM.html The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. 33/102 Gene Ontology CC GO:0016528 1.39159151042287e-05 3.98188065853671e-05 90 145 138 1.26509119354178e-06 60 1.55123142615289 1.56913174827757 1 9.51429063645929 90 60 138 187 198 74 98 144 282 217 107 117 M17527 GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX.html A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. 10/26 Gene Ontology CC GO:0034663 0.000140824985968806 0.000313064776499884 85 178.636363636364 139 1.28030910159282e-05 20 3.55389468427202 3.55389468427202 1 17.3608042365846 83 401 151 20 526 139 169 47 76 262 91 118 M17468 GO_FILOPODIUM_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_TIP.html The end of a filopodium distal to the body of the cell. 20/35 Gene Ontology CC GO:0032433 3.52751258944691e-06 1.36839078973175e-05 220 164.454545454545 140 3.20683476865959e-07 44 1.83172871548515 1.70712056983198 1 12.4191482010819 218 170 140 49 135 205 117 321 44 107 303 119 M17166 GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 599/2062 Gene Ontology CC GO:0031226 7.6395827091078e-28 9.5355640278439e-26 160 137.636363636364 141 7.63958270910784e-29 1 1.89876292285034 1.98400871650647 1 66.2255003172362 58 54 459 169 68 141 157 153 157 1 97 120 M17416 GO_RUFFLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_MEMBRANE.html The portion of the plasma membrane surrounding a ruffle. 57/146 Gene Ontology CC GO:0032587 6.975517359085e-06 2.30391373345779e-05 165 152.909090909091 142 6.34139952398571e-07 79 1.63789644832888 1.82264291140169 1 10.5883766248643 119 295 128 134 165 150 79 89 220 161 142 121 M17186 GO_BASAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 22/58 Gene Ontology CC GO:0009925 1.15136611054922e-07 1.62314539487182e-06 550 273.090909090909 144 1.04669651891433e-08 29 2.13116674624789 -2.48664487446509 -1 17.1998649945178 549 76 29 99 144 508 569 283 139 52 556 122 M17350 GO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON.html Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. 951/2385 Gene Ontology CC GO:0005856 3.38379441986816e-07 3.066277993715e-06 495 207.272727272727 144 3.38379493512117e-08 33 1.53866842728842 1.74403089117025 1 11.8254993724856 128 252 491 491 33 144 109 84 198 249 101 123 M17685 GO_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_CILIUM.html A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors. 108/307 Gene Ontology CC GO:0072372 1.60206266493244e-06 8.09641500033063e-06 150 145 146 1.45642166506561e-07 58 1.20318085405539 1.1696387709651 1 8.53984895796726 118 112 201 150 97 96 58 184 260 146 173 124 M17835 GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE.html A clathrin coat found on a vesicle of the trans-Golgi network. 11/16 Gene Ontology CC GO:0030130 1.33684238778277e-05 3.86347450069221e-05 130 174.454545454545 146 1.21531864659084e-06 71 0.821321334673183 -0.824656700599956 -1 5.05248510662506 127 114 241 71 196 103 146 180 275 357 109 125 M17012 GO_IMMUNOLOGICAL_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE.html An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 20/68 Gene Ontology CC GO:0001772 1.11637438937061e-05 3.29216529110314e-05 195 135.272727272727 149 1.01489095852135e-06 62 1.74144608980545 2.26655037038485 1 10.8814799252052 213 149 124 153 192 194 97 63 62 172 69 126 M17666 GO_MHC_CLASS_II_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. 4/11 Gene Ontology CC GO:0042613 0.000362196250014116 0.00073455941230933 150 180.363636363636 150 3.62255297315068e-05 64 1.79920259003863 -1.79920259003863 -1 7.86015626442001 150 64 551 85 275 125 162 205 109 180 78 127 M17521 GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. 3/14 Gene Ontology CC GO:0031235 2.84171806859643e-07 2.88634899728623e-06 35 159.363636363636 155 2.84171843198776e-08 9 1.74066253618772 -2.17680296092351 -1 13.4416583544 238 34 526 35 26 166 289 116 9 155 159 128 M17073 GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX.html Any protein complex that is part of the plasma membrane and which functions as a receptor. 71/236 Gene Ontology CC GO:0098802 5.65044192759051e-06 1.95501449533046e-05 310 244.545454545455 156 5.13677858194542e-07 98 1.90484321318899 2.25116062931134 1 12.5034524245453 307 123 104 126 156 538 508 231 98 135 364 129 M17760 GO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM.html A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. 237/685 Gene Ontology CC GO:0005929 6.0938311565078e-07 4.45663350390702e-06 280 186.454545454545 156 5.53984804041175e-08 50 1.23313228348976 1.1665574555086 1 9.19813775490479 148 156 277 248 50 88 82 341 276 241 144 130 M17070 GO_SARCOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the sarcoplasmic reticulum. 17/45 Gene Ontology CC GO:0033017 5.68239507293282e-06 1.95501449533046e-05 160 161.363636363636 157 5.16582704553005e-07 37 1.24320677943716 1.40939017921764 1 8.16044946642958 70 180 158 102 157 62 37 224 433 267 85 131 M17059 GO_LATE_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a late endosome. 72/129 Gene Ontology CC GO:0031902 1.29625754204395e-06 7.10142493132185e-06 230 158.545454545455 158 1.17841664164533e-07 47 1.41132450917868 -1.1250411367006 -1 10.1292312397039 229 47 194 158 87 93 122 299 142 164 209 132 M17081 GO_PLATELET_ALPHA_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_MEMBRANE.html The lipid bilayer surrounding the platelet alpha granule. 10/16 Gene Ontology CC GO:0031092 0.0034866035194931 0.00599778819722325 65 185.727272727273 158 0.000317467404444656 43 2.44014301789568 2.44014301789568 1 7.55817463577192 65 262 95 220 359 83 43 158 443 201 114 133 M17417 GO_EXTERNAL_ENCAPSULATING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_ENCAPSULATING_STRUCTURE.html A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space. 7/13 Gene Ontology CC GO:0030312 0.000507469100216168 0.000987599797727089 160 210.454545454545 158 5.07585023674818e-05 103 1.87427107154602 1.87427107154602 1 7.85223489592763 158 199 501 237 286 154 103 147 156 226 148 134 M17280 GO_AXONAL_GROWTH_CONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_GROWTH_CONE.html The migrating motile tip of a growing nerve cell axon. 23/44 Gene Ontology CC GO:0044295 3.92376176489403e-05 9.90364323191594e-05 180 168.090909090909 161 3.56711977094013e-06 126 1.37279913012443 1.53738036441254 1 7.66265287725128 179 160 161 180 224 142 142 174 149 126 212 135 M17680 GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. 104/420 Gene Ontology CC GO:0009897 6.42546602130042e-11 1.95469440016402e-09 170 131.181818181818 161 5.84133274680735e-12 15 1.8296643636975 1.85318882020607 1 22.2122033630506 49 186 15 170 163 161 148 168 227 30 126 136 M17798 GO_BASAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PART_OF_CELL.html The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. 35/84 Gene Ontology CC GO:0045178 4.52164142978488e-09 9.33395980862735e-08 160 245.636363636364 164 4.1105831264347e-10 23 2.21946952574085 -2.48664487446509 -1 21.7498513235728 233 73 23 164 158 461 470 517 160 64 379 137 M17255 GO_MICROVILLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS.html Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. 48/118 Gene Ontology CC GO:0005902 2.68747916768302e-07 2.87288923068963e-06 580 265.818181818182 167 2.44316317816413e-08 19 2.00625511061411 -2.10677767178013 -1 15.4982813771686 576 106 36 138 19 556 496 362 167 57 411 138 M17560 GO_INTRACILIARY_TRANSPORT_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE.html A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. 19/39 Gene Ontology CC GO:0030990 4.52166387098386e-06 1.63345107339292e-05 130 176 167 4.1106119676312e-07 53 0.974250909805344 0.889875625843258 1 6.50100455214616 167 127 235 184 151 84 53 251 277 280 127 139 M17799 GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX.html Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. 5/14 Gene Ontology CC GO:0005890 6.47711205909075e-06 2.1766109128805e-05 35 240.454545454545 168 6.47713093800947e-07 14 1.5690154828328 -2.28976312783162 -1 10.1970786775648 473 33 573 124 168 350 152 34 14 194 530 140 M17825 GO_EXOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an exocytic vesicle 24/80 Gene Ontology CC GO:0099501 2.04791182664963e-06 9.39438917304356e-06 65 216.909090909091 168 1.86173975726343e-07 61 1.41048651347852 1.45574936772601 1 9.8842798324367 312 61 144 144 111 304 168 484 205 63 390 141 M17205 GO_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_COMPLEX.html An ion channel complex through which sodium ions pass. 3/17 Gene Ontology CC GO:0034706 1.75412013695282e-05 4.88876855396633e-05 265 199.272727272727 169 1.7541339833252e-06 21 2.88811833587265 -3.00961171586381 -1 17.3551656925749 264 108 465 81 206 274 451 65 21 88 169 142 M17514 GO_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIDE_OF_MEMBRANE.html A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. 215/702 Gene Ontology CC GO:0098552 3.87264240738119e-13 1.72183639343564e-11 125 157.636363636364 169 3.52058400671079e-14 10 1.74141878455101 1.81544431239494 1 26.1296201041721 124 143 10 178 169 279 254 175 239 13 150 143 M17491 GO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE.html The external part of the cell wall and/or plasma membrane. 354/1190 Gene Ontology CC GO:0009986 2.40737096316486e-24 1.73932552088661e-22 10 144.727272727273 170 2.18851905742259e-25 6 1.85550624968007 1.95851214378502 1 56.2820056678685 149 67 6 177 76 330 252 186 172 7 170 144 M17722 GO_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE.html Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. 195/538 Gene Ontology CC GO:0030133 4.36855207633261e-06 1.58806484284292e-05 555 268.636363636364 174 3.97141886455869e-07 69 1.58505356084161 -1.38643198672051 -1 10.6038229876887 553 69 114 83 150 336 578 380 174 98 420 145 M17603 GO_NUCLEAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MATRIX.html The dense fibrillar network lying on the inner side of the nuclear membrane. 54/158 Gene Ontology CC GO:0016363 2.28472508084112e-06 1.00671693055827e-05 320 222.090909090909 175 2.07702495777965e-07 16 2.59441663026952 3.55209764247226 1 18.0722810963973 318 245 105 94 118 561 526 61 16 175 224 146 M17674 GO_PRESYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPSE.html The part of a synapse that is part of the presynaptic cell. 132/414 Gene Ontology CC GO:0098793 1.75353632690084e-06 8.51080645020431e-06 275 185 178 1.59412520416319e-07 86 1.47361800434033 1.60579905883904 1 10.4148073207352 275 178 119 109 102 269 224 310 189 86 174 147 M17230 GO_CILIARY_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TIP.html Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. 25/63 Gene Ontology CC GO:0097542 1.93855231661899e-05 5.28529829719707e-05 160 197 179 1.762335816891e-06 69 0.820941883672586 0.886295145009342 1 4.89441123161617 160 93 316 245 207 77 69 179 370 334 117 148 M17445 GO_LATE_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME.html A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. 132/279 Gene Ontology CC GO:0005770 2.35934647267191e-06 1.01768825463012e-05 180 200 179 2.14486272991833e-07 86 1.44625378664035 -1.32554073864118 -1 10.0648765403562 291 86 179 142 119 126 296 382 180 130 269 149 M17792 GO_NEURONAL_CELL_BODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_CELL_BODY_MEMBRANE.html The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. 12/44 Gene Ontology CC GO:0032809 9.08025363079212e-05 0.000208269309468168 170 206.272727272727 179 8.25511675431769e-06 109 1.35216097177126 1.63158493547445 1 6.93895824361645 170 197 155 166 246 227 257 109 397 179 166 150 M17273 GO_BLOOD_MICROPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_MICROPARTICLE.html A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. 66/447 Gene Ontology CC GO:0072562 1.0252675944531e-06 6.10932649065871e-06 250 204.636363636364 181 9.3206188387238e-08 44 2.25892269522011 2.2850764114582 1 16.4183233404491 246 124 44 181 77 382 268 386 131 93 319 151 M17659 GO_CILIARY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_MEMBRANE.html The portion of the plasma membrane surrounding a cilium. 36/102 Gene Ontology CC GO:0060170 5.94375506153622e-05 0.000144102939246373 235 214 182 5.40355968222524e-06 82 1.44949155979552 -1.60808548666917 -1 7.76162828272751 362 169 182 143 233 233 504 117 201 128 82 152 M17574 GO_CILIARY_BASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASE.html Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. 13/25 Gene Ontology CC GO:0097546 9.45803026406066e-06 2.89245581620479e-05 260 197.818181818182 183 8.59824629578856e-07 47 1.24673465169034 1.14382650604585 1 7.88795715766336 256 96 212 86 183 165 94 535 47 286 216 153 M17453 GO_PRESYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_MEMBRANE.html A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. 23/95 Gene Ontology CC GO:0042734 0.000268030779239772 0.00055329210857353 120 166.181818181818 185 2.43694035984292e-05 62 1.15646287197826 1.37650809013178 1 5.25062949140263 120 263 199 185 269 89 62 83 252 187 119 154 M17098 GO_EXOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE.html A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. 70/211 Gene Ontology CC GO:0070382 3.81921512144267e-06 1.43276129898761e-05 130 301.181818181818 186 3.47201977422044e-07 87 1.48843063019024 -1.31941296765637 -1 10.0501605486723 570 87 127 128 141 460 469 539 186 92 514 155 M17675 GO_A_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_A_BAND.html The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. 18/72 Gene Ontology CC GO:0031672 0.00128341357154397 0.00232543274091666 200 192.454545454545 186 0.000116742080756454 110 2.13846712020504 1.96371556439057 1 7.85038810903744 197 196 110 172 302 185 140 256 113 186 260 156 M17762 GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 78/190 Gene Ontology CC GO:0019897 4.61533825685021e-07 3.70509098952698e-06 215 181.454545454545 187 4.19576293190323e-08 12 1.65414172285706 1.83941693400654 1 12.5234635086603 215 12 74 159 43 318 187 414 221 77 276 157 M17100 GO_MRNA_CLEAVAGE_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_FACTOR_COMPLEX.html Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. 13/20 Gene Ontology CC GO:0005849 0.000220316345654818 0.000469899807337581 165 258.909090909091 188 2.00307647330217e-05 55 1.89478653721922 -1.89478653721922 -1 8.79020033200442 188 443 250 463 446 160 144 55 163 373 163 158 M17662 GO_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE.html Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. 154/351 Gene Ontology CC GO:0030135 1.04677978644115e-05 3.13491562986002e-05 160 273.363636363636 188 9.51622515587906e-07 70 1.64191335409771 1.8266786225504 1 10.308196555304 366 158 156 70 188 540 399 348 185 147 450 159 M17525 GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN.html The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. 14/28 Gene Ontology CC GO:0035327 5.4876942095978e-05 0.000134402002252014 240 162 190 4.9889373634337e-06 37 1.77716841493343 -1.77716841493343 -1 9.5912293472035 141 237 237 239 231 76 190 37 88 243 63 160 M17796 GO_PHOTORECEPTOR_OUTER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT.html The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes. 33/111 Gene Ontology CC GO:0001750 1.09293396421591e-05 3.24934438100123e-05 525 277.272727272727 190 9.93581267109328e-07 97 1.74337509129248 -1.76848669020958 -1 10.9073513483452 522 126 113 108 190 575 367 350 153 97 449 161 M17647 GO_MAIN_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAIN_AXON.html The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. 33/108 Gene Ontology CC GO:0044304 2.73371812608875e-07 2.87288923068963e-06 250 199.636363636364 191 2.4851986052549e-08 20 1.60942626238984 1.79331413137278 1 12.4327862970415 248 75 149 40 20 377 303 421 116 191 256 162 M17341 GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS.html A cell part consisting of multiple, closely packed actin-based cell projections. 75/238 Gene Ontology CC GO:0098862 2.97594929834388e-06 1.19451298225192e-05 195 227.818181818182 192 2.70541211266427e-07 111 1.89353169134194 1.54386777220151 1 12.9939570934515 311 192 111 167 127 254 179 279 191 212 483 163 M17348 GO_CYTOSKELETAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PART.html Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. 685/1737 Gene Ontology CC GO:0044430 3.18008052774944e-07 2.96465571780513e-06 160 221.181818181818 192 3.18008098283058e-08 31 1.55820916223804 1.78830245490421 1 12.0074742169366 156 278 490 435 31 219 125 112 192 244 151 164 M17360 GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX.html Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. 10/41 Gene Ontology CC GO:0005834 1.24972013203546e-05 3.66669155490606e-05 115 220.181818181818 193 1.13611566471334e-06 113 1.66377039209139 1.35977433291663 1 10.2875964181608 293 115 123 183 193 262 194 253 176 113 517 165 M17602 GO_NONMOTILE_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM.html A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 70/208 Gene Ontology CC GO:0031513 2.01817582688399e-06 9.33204502351158e-06 200 195.181818181818 193 1.83470698024119e-07 88 1.4263123867248 1.33419364029221 1 10.0009324161386 196 137 193 174 110 209 88 367 211 157 305 166 M17785 GO_TRANS_GOLGI_NETWORK_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_MEMBRANE.html The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. 45/97 Gene Ontology CC GO:0032588 1.30889201241863e-05 3.80170644813048e-05 195 162.363636363636 193 1.18990890886226e-06 66 1.26477601282305 -1.29539970161216 -1 7.79280567059482 122 193 209 145 195 82 218 66 215 257 84 167 M17604 GO_AXOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXOLEMMA.html The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. 6/34 Gene Ontology CC GO:0030673 7.14175602495084e-05 0.000169177663213999 205 211.272727272727 194 7.14198555638891e-06 4 2.85112369746148 3.13632895511279 1 14.9900851984622 204 194 543 17 240 366 309 122 4 150 175 168 M17407 GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE.html The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 26/65 Gene Ontology CC GO:0031228 0.00316330140327601 0.00547421620087884 95 212.090909090909 195 0.000287987179858127 95 1.1746696780755 1.26311003025523 1 3.70341508120374 95 242 176 323 315 99 101 195 421 246 120 169 M17515 GO_PHOTORECEPTOR_CONNECTING_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CONNECTING_CILIUM.html A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments. 22/62 Gene Ontology CC GO:0032391 1.87021686247097e-06 8.86053562711657e-06 110 198.909090909091 195 1.70019859303778e-07 65 1.20739022645444 1.16023443331208 1 8.50380456600613 138 195 281 228 107 108 65 441 214 264 147 170 M17581 GO_DESMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DESMOSOME.html A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. 14/36 Gene Ontology CC GO:0030057 7.84357980959196e-06 2.50474537565975e-05 190 238.818181818182 195 7.13055252196431e-07 17 1.90682648162848 -2.39894459130836 -1 12.2304257708421 395 221 150 189 189 408 544 17 118 195 201 171 M17752 GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. 11/23 Gene Ontology CC GO:0033176 0.000135174639836852 0.000304011446792609 50 149.636363636364 195 1.22893587353827e-05 38 1.17690914976213 -1.17690914976213 -1 5.77011872636429 46 247 218 195 252 39 38 48 233 269 61 172 M17622 GO_ENDOSOMAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOMAL_PART.html Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. 283/614 Gene Ontology CC GO:0044440 6.31178773529034e-06 2.13345807660691e-05 200 192.454545454545 197 5.73800531258809e-07 105 1.419736732912 -1.32892215597505 -1 9.24412305576814 189 175 202 197 162 105 288 234 212 154 199 173 M17174 GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE.html The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 9/16 Gene Ontology CC GO:0031231 8.60463684565585e-07 5.37751193986866e-06 80 176.272727272727 198 8.60464017744754e-08 1 0.821918142130532 -0.821918142130532 -1 6.0373606410745 78 198 460 260 298 23 1 15 238 329 39 174 M17304 GO_BRUSH_BORDER http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER.html The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. 61/186 Gene Ontology CC GO:0005903 2.17622478339769e-06 9.75083662638655e-06 280 217.454545454545 198 1.9783881237338e-07 108 1.74836898794787 1.54386777220151 1 12.2126446497067 276 146 108 116 115 222 153 452 209 198 397 175 M17519 GO_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of a membrane. 502/1255 Gene Ontology CC GO:0098796 1.60530304141356e-06 8.09641500033063e-06 575 318.909090909091 198 1.60530420106377e-07 104 1.5206907381956 -1.19902889713468 -1 10.7934473777314 572 135 525 198 104 145 450 566 190 167 456 176 M17510 GO_POLE_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLE_PLASM.html Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. 8/18 Gene Ontology CC GO:0045495 0.0070715536460509 0.011578917868038 200 236.090909090909 199 0.000709415804104518 91 1.67117518315092 1.67117518315092 1 4.51084242180891 168 284 523 199 358 236 196 130 91 235 177 177 M17642 GO_NUCLEAR_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PERIPHERY.html The portion of the nuclear lumen proximal to the inner nuclear membrane. 61/182 Gene Ontology CC GO:0034399 1.03853915716612e-05 3.12643558771883e-05 310 254 199 9.44130963418409e-07 26 2.59441663026952 3.55209764247226 1 16.2924200254519 310 313 118 161 187 567 554 85 26 199 274 178 M17707 GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX.html Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). 27/45 Gene Ontology CC GO:0030119 1.42594889244642e-05 4.06009093514302e-05 115 217.454545454545 199 1.29632557721863e-06 113 0.841136100307764 -0.869444163841157 -1 5.14910174524707 169 113 310 238 199 130 239 115 350 393 136 179 M16981 GO_MULTIVESICULAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY.html A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 17/51 Gene Ontology CC GO:0005771 1.5250967227821e-05 4.32110738121596e-05 520 308.636363636364 200 1.38646117749856e-06 70 1.64823977731666 -1.65389749970369 -1 10.0276988374357 548 188 133 165 200 514 430 516 70 112 519 180 M16998 GO_ER_TO_GOLGI_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE.html A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. 52/130 Gene Ontology CC GO:0030134 0.000710629978657462 0.0013467020579148 305 250.636363636364 201 6.46236023346873e-05 93 2.05868144122024 2.10529976789394 1 8.23829081844616 305 201 117 110 292 499 435 166 93 122 417 181 M17437 GO_CONNEXON_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNEXON_COMPLEX.html An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. 9/20 Gene Ontology CC GO:0005922 0.00142540908175795 0.00255073204104053 190 256.090909090909 202 0.000142632421398256 102 2.41060261599115 2.28939630864819 1 8.71445284801261 182 190 505 190 305 313 200 364 202 102 264 182 M17113 GO_T_CELL_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_COMPLEX.html A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. 6/24 Gene Ontology CC GO:0042101 0.000163826253801723 0.000357326696971306 350 207.090909090909 207 1.63838332623646e-05 50 2.34756295177272 -2.80495818778103 -1 11.2799230053689 349 174 452 207 285 215 225 50 57 148 116 183 M17190 GO_CLATHRIN_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE.html A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. 92/208 Gene Ontology CC GO:0030136 3.39665812221567e-06 1.33555673104807e-05 135 254.636363636364 208 3.08787578768009e-07 87 1.52424479271497 -1.40226970022345 -1 10.356814160507 472 131 154 87 133 238 493 320 208 160 405 184 M17021 GO_SPERM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PART.html Any constituent part of a sperm, a mature male germ cell that develops from a spermatid. 70/232 Gene Ontology CC GO:0097223 2.1327390845088e-06 9.63064992848505e-06 200 239.727272727273 210 1.93885559276923e-07 114 1.24388251661916 1.24877853266242 1 8.69806325729447 200 375 210 451 114 127 138 248 378 265 131 185 M17250 GO_NODE_OF_RANVIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NODE_OF_RANVIER.html An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. 8/32 Gene Ontology CC GO:0033268 2.73410759698803e-06 1.12781544013989e-05 220 211.272727272727 210 2.73411096089881e-07 71 1.11962953088835 -1.15421424869078 -1 7.72216352899062 216 211 477 210 128 121 173 71 222 315 180 186 M17479 GO_CHD_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHD_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. 7/23 Gene Ontology CC GO:0090545 4.73175203332466e-05 0.00011709118876321 230 226 212 4.73185278899197e-06 118 0.962219755158673 -0.850938764749806 -1 5.27333940575448 262 212 516 200 230 122 170 133 295 228 118 187 M17057 GO_ENDOSOME_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_LUMEN.html The volume enclosed by the membrane of an endosome. 22/42 Gene Ontology CC GO:0031904 0.000390595135657915 0.0007893845748611 215 233.636363636364 213 3.55149545842858e-05 146 1.81372494268707 -1.78744741311661 -1 7.84456116997215 195 301 146 308 274 212 322 213 177 216 206 188 M17282 GO_APICAL_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_DENDRITE.html A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. 9/30 Gene Ontology CC GO:0097440 0.00219761120417833 0.00383752047134463 265 247 215 0.000219978750656347 71 1.9289286343249 1.77778224690886 1 6.49620657307087 261 206 483 127 312 342 327 215 71 190 183 189 M17738 GO_MITOCHONDRIAL_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ENVELOPE.html The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. 426/833 Gene Ontology CC GO:0005740 2.38745226256928e-05 6.33003398057359e-05 140 297.545454545455 216 2.17043470157085e-06 137 1.1559479371101 -0.932201095496818 -1 6.76547046205049 139 430 425 569 214 137 216 193 318 443 189 190 M17818 GO_GAP_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION.html A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons. 11/35 Gene Ontology CC GO:0005921 0.000413325001646808 0.000832410630494268 165 192.272727272727 216 3.7582061410249e-05 75 2.33116083246837 2.21830742988945 1 10.0076290340577 161 182 75 222 276 248 180 227 216 91 237 191 M17065 GO_PLATELET_ALPHA_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE.html A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). 43/117 Gene Ontology CC GO:0031091 4.49340135848358e-05 0.000111947671776013 85 194.363636363636 217 4.0849937607418e-06 72 1.91391695685602 1.90062238417404 1 10.5410607586306 84 244 72 236 227 171 133 298 335 121 217 192 M17124 GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription. 10/28 Gene Ontology CC GO:0090568 5.27732521096378e-06 1.87134599505342e-05 370 230.727272727273 217 4.79757988197324e-07 154 0.913266301119786 -0.850938764749806 -1 6.01889264489519 368 189 232 208 154 180 236 217 310 260 184 193 M17518 GO_CLATHRIN_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated vesicle. 44/104 Gene Ontology CC GO:0030665 8.09316484985059e-06 2.52856718011548e-05 460 317 217 7.35744965674625e-07 39 1.31417201753918 -1.13750984560456 -1 8.42159647381356 459 91 170 39 177 511 521 557 217 197 548 194 M17005 GO_LYSOSOMAL_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_LUMEN.html The volume enclosed within the lysosomal membrane. 56/120 Gene Ontology CC GO:0043202 5.49737772940159e-06 1.93749044365495e-05 205 240.636363636364 218 4.99762860576493e-07 136 1.56972788104128 1.76248316402028 1 10.3123011731579 191 236 136 277 155 385 335 218 204 204 306 195 M17149 GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX.html A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. 10/15 Gene Ontology CC GO:0005847 0.000342309407368827 0.000696671962884443 180 245.818181818182 220 3.11238800608644e-05 62 3.26707235433041 -3.26707235433041 -1 14.377563365814 180 366 220 377 401 213 222 62 124 341 198 196 M17601 GO_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL.html Extracellular matrix material consisting of polysaccharides and protein. 5/23 Gene Ontology CC GO:0043205 2.87075314522683e-05 7.47430323396896e-05 105 251.727272727273 220 2.8707902314074e-06 27 2.7247606968414 -1.64811701206332 -1 15.6732343345797 335 101 542 133 220 393 490 103 27 193 232 197 M17550 GO_INTRACILIARY_TRANSPORT_PARTICLE_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE_B.html The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. 12/24 Gene Ontology CC GO:0030992 0.000569971995831466 0.00110181877455046 145 212.272727272727 222 5.18290651564813e-05 21 0.82659826187541 0.940786268228808 1 3.408256957859 144 222 279 246 293 90 21 204 436 275 125 198 M17306 GO_PLATELET_DENSE_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_TUBULAR_NETWORK.html A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. 8/14 Gene Ontology CC GO:0031094 0.0536394527453886 0.0777032673855504 185 263 223 0.00549799583025735 130 1.20783025379877 1.26856153517742 1 1.86815462206186 172 184 485 194 356 223 130 296 417 181 255 199 M17320 GO_PLATELET_ALPHA_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet alpha granule. 29/92 Gene Ontology CC GO:0031093 1.35943566594839e-06 7.27549828627935e-06 140 210.818181818182 223 1.23585136907165e-07 89 1.87039648644944 1.82653539952857 1 13.3966198215997 137 229 93 223 89 245 208 408 284 115 288 200 M17080 GO_CYTOPLASMIC_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SIDE_OF_MEMBRANE.html The side of a membrane that faces the cytoplasm. 89/232 Gene Ontology CC GO:0098562 3.86813464054437e-07 3.38754821550704e-06 330 228.636363636364 224 3.51648665514238e-08 35 1.59316147239353 1.7117986065652 1 12.14820372919 328 46 80 182 35 516 372 339 224 41 352 201 M17784 GO_CILIARY_BASAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASAL_BODY.html A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. 44/106 Gene Ontology CC GO:0036064 4.31138650097816e-05 0.000107877982578588 230 241.090909090909 226 3.91951908586263e-06 107 0.933106878836179 0.93308959814329 1 5.16008430132417 107 228 362 298 226 159 149 161 385 364 213 202 M17038 GO_CATION_TRANSPORTING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_COMPLEX.html Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 9/21 Gene Ontology CC GO:0090533 3.39372895426826e-05 8.67953688304005e-05 440 280.363636363636 228 3.39378078366522e-06 28 1.38373287320504 -1.83624364242854 -1 7.83420508994841 437 28 439 125 223 399 228 346 171 188 500 203 M17442 GO_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COMPLEX.html A protein complex which is capable of ATPase activity. 15/33 Gene Ontology CC GO:1904949 4.74036992570781e-05 0.00011709118876321 380 246.363636363636 228 4.30952006380429e-06 77 1.62613762084746 -1.59103430259062 -1 8.91186819561382 378 95 120 77 228 466 291 401 114 205 335 204 M17791 GO_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a transport vesicle. 81/216 Gene Ontology CC GO:0030658 3.5688322004261e-05 9.08715864249464e-05 305 233.363636363636 232 3.24444554110033e-06 109 1.45557505562535 -1.55804575709689 -1 8.20050815418543 282 159 153 111 222 301 459 304 232 109 235 205 M17223 GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the rough endoplasmic reticulum. 15/30 Gene Ontology CC GO:0030867 0.00105399156878724 0.00194015008521982 280 217.818181818182 233 9.58633510427435e-05 88 1.63855886967387 -1.37410101342625 -1 6.19489507670104 323 277 185 279 319 203 147 88 90 252 233 206 M17136 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. 12/26 Gene Ontology CC GO:0033177 5.95858174392442e-05 0.000144102939246373 350 217.727272727273 234 5.41703921366159e-06 54 0.738264626251214 -0.738264626251214 -1 3.95320381400114 117 387 346 268 234 65 115 95 347 367 54 207 M17229 GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM.html The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. 8/22 Gene Ontology CC GO:0097038 0.00150247891828648 0.00268034819373328 235 272.090909090909 234 0.000150349573529734 118 1.18157513948953 -1.18157513948953 -1 4.23599920070271 177 250 473 233 307 118 164 479 419 234 139 208 M17766 GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 21/45 Gene Ontology CC GO:0046658 2.23191962226848e-05 6.00023042637758e-05 510 317.090909090909 234 2.0290384232852e-06 51 1.64164970368853 -2.0147881147956 -1 9.66133852895526 508 51 101 179 210 541 489 532 234 89 554 209 M17682 GO_LYTIC_VACUOLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_MEMBRANE.html The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. 178/391 Gene Ontology CC GO:0098852 7.99208375458282e-06 2.52427563396113e-05 275 242.545454545455 236 7.26555708008669e-07 157 1.24053186460573 -1.2818780373055 -1 7.95096467712249 236 157 272 271 174 206 333 212 315 220 272 210 M17729 GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. 13/29 Gene Ontology CC GO:0031233 8.20963929237375e-05 0.000190569136987632 465 269.181818181818 236 7.46358696702827e-06 100 1.91632113318208 -2.70156122780378 -1 9.93712938393413 463 150 100 213 242 390 429 225 236 144 369 211 M17262 GO_CELL_CORTEX_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_REGION.html The complete extent of cell cortex that underlies some some region of the plasma membrane 8/25 Gene Ontology CC GO:0099738 3.86696821180047e-06 1.43276129898761e-05 445 257.363636363636 237 3.86697494086637e-07 55 1.62957919600287 -1.55638602753354 -1 11.0032219322104 443 82 479 100 147 237 248 548 55 90 402 212 M17593 GO_CIS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. 28/52 Gene Ontology CC GO:0005801 4.05070725965414e-05 0.000101796034612178 220 244.727272727273 240 3.68252894948836e-06 155 1.25303571254581 1.32809446931767 1 6.9733122448115 220 209 322 242 225 240 163 263 293 360 155 213 M17767 GO_AXONEMAL_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX.html A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 3/21 Gene Ontology CC GO:0005858 8.48184134755698e-06 2.63575499940211e-05 570 273.636363636364 240 8.48187372146557e-07 2 2.02807971059026 -3.16446073698654 -1 12.9455505080148 568 119 569 106 182 398 240 318 2 240 268 214 M17816 GO_CLATHRIN_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_ADAPTOR_COMPLEX.html A membrane coat adaptor complex that links clathrin to a membrane. 20/34 Gene Ontology CC GO:0030131 1.26805092656363e-05 3.70168401794837e-05 290 253.636363636364 241 1.15278021409143e-06 148 0.837068388658161 -0.873456569486151 -1 5.17103419528073 286 148 285 168 194 241 337 233 331 359 208 215 M17197 GO_TRANS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. 116/247 Gene Ontology CC GO:0005802 8.43357501756638e-07 5.37751193986866e-06 330 259.636363636364 242 7.66688931866473e-08 67 1.31788105489883 -1.21819817474409 -1 9.68043267450307 326 152 190 205 67 259 572 351 274 218 242 216 M17347 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. 8/16 Gene Ontology CC GO:0033178 0.00437516141668972 0.00737272098789113 345 239.545454545455 242 0.000438379927810851 50 1.31687389358459 -1.31687389358459 -1 3.91438058790678 143 343 489 281 342 109 50 148 242 316 172 217 M17489 GO_MITOCHONDRIAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PART.html Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 580/1145 Gene Ontology CC GO:0044429 2.13550548661913e-05 5.76786061339186e-05 130 311.090909090909 242 2.13552600862326e-06 130 1.19737127302165 -0.948284013529361 -1 7.07532821165899 130 469 517 563 213 136 198 242 296 456 202 218 M16999 GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX.html A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. 14/29 Gene Ontology CC GO:0005669 7.89208564262299e-07 5.19053678649904e-06 465 266.818181818182 244 7.17462588523772e-08 24 1.60424406824585 2.03252206510231 1 11.8182682386249 464 161 174 244 60 566 468 70 24 296 408 219 M17208 GO_M_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_M_BAND.html The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. 9/40 Gene Ontology CC GO:0031430 0.0106262488258852 0.0168735489597848 230 323.181818181818 248 0.00106774061737664 139 1.7228446255063 -2.57534600974121 -1 4.25755363850483 478 248 468 227 349 484 219 139 230 189 524 220 M17253 GO_MOTILE_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM.html A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles. 50/165 Gene Ontology CC GO:0031514 8.67518493355151e-05 0.000200314924179261 250 268 248 7.88684276185927e-06 120 1.1256292008214 0.976897458349136 1 5.80298939160456 174 270 246 346 244 182 120 400 329 389 248 221 M17194 GO_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LUMEN.html The volume enclosed by the membrane or protein that forms a vesicle. 54/213 Gene Ontology CC GO:0031983 3.79892193685266e-06 1.43276129898761e-05 250 280.909090909091 249 3.45357136071018e-07 61 2.08543568152252 -2.22035248563052 -1 14.0812497554678 257 249 61 235 140 419 345 570 248 111 455 222 M17565 GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. 54/135 Gene Ontology CC GO:0031234 6.7192093585104e-07 4.6791602520711e-06 320 254.636363636364 249 6.10837400971167e-08 54 1.49012574437933 1.5146608274174 1 11.0711388454063 320 104 94 204 54 439 249 489 286 84 478 223 M17088 GO_SECRETORY_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_LUMEN.html The volume enclosed by the membrane of a secretory granule. 40/169 Gene Ontology CC GO:0034774 3.73302044295649e-06 1.42893100399262e-05 185 251.090909090909 251 3.3936607066029e-07 84 2.01932202364236 1.80560986834799 1 13.6381105764461 185 281 84 278 138 308 235 502 251 106 394 224 M17389 GO_ENDOCYTIC_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_LUMEN.html The volume enclosed by the membrane of an endocytic vesicle. 12/38 Gene Ontology CC GO:0071682 2.30213898469552e-05 6.16035339423152e-05 460 328.818181818182 251 2.09287552295274e-06 99 3.0053967663999 -3.01592833480987 -1 17.6392633892271 458 251 99 162 211 577 527 550 135 177 470 225 M17684 GO_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENVELOPE.html A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. 635/1396 Gene Ontology CC GO:0031975 7.18382414682433e-06 2.3459041564206e-05 220 327 251 7.18384737022819e-07 158 1.18000532085087 -0.977811019128676 -1 7.6153822020191 222 451 553 574 172 158 251 220 327 450 219 226 M17743 GO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM.html The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). 834/2134 Gene Ontology CC GO:0005783 5.9893205190068e-07 4.43824007690504e-06 375 275.363636363636 251 5.98932213324562e-08 52 1.54228605820354 1.82280084591146 1 11.5080284546636 374 65 564 251 52 475 401 207 170 99 371 227 M17119 GO_SECRETORY_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_VESICLE.html A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. 230/739 Gene Ontology CC GO:0099503 1.76694943602858e-06 8.51080645020431e-06 255 231.909090909091 253 1.60631895924657e-07 40 1.66500353029372 1.82138603415952 1 11.7674261010867 253 110 41 249 105 416 311 374 264 40 388 228 M17129 GO_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. 174/423 Gene Ontology CC GO:0030139 6.87750824718206e-06 2.29585777603223e-05 445 316.272727272727 253 6.25229977030051e-07 87 1.58496403588769 -1.55293471586326 -1 10.2495497584385 445 217 87 129 164 563 370 500 253 176 575 229 M17592 GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX.html A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. 3/20 Gene Ontology CC GO:0005892 3.64252627437945e-05 9.23412362540052e-05 255 267.636363636364 254 3.64258598174633e-06 29 1.95916701446698 -1.95916701446698 -1 11.0186467916875 254 266 540 243 449 255 382 29 97 239 190 230 M17156 GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. 7/15 Gene Ontology CC GO:0016471 0.000733017216422885 0.00138458807546545 95 231.545454545455 255 7.33259120140649e-05 52 0.703904071763211 -0.703904071763211 -1 2.80501235013204 93 255 458 262 297 61 52 101 373 489 106 231 M17616 GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT.html A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. 7/15 Gene Ontology CC GO:0044322 0.000557100643201272 0.00108055091198099 310 225.181818181818 255 5.57240355005358e-05 71 1.01761854731877 -1.01761854731877 -1 4.20788588030673 121 282 544 266 310 95 135 90 255 308 71 232 M17323 GO_MICROVILLUS_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_MEMBRANE.html The portion of the plasma membrane surrounding a microvillus. 13/30 Gene Ontology CC GO:0031528 7.86111771398367e-05 0.000183956519784719 295 276.545454545455 256 7.14672602206496e-06 134 1.60956611081584 -1.40140300452614 -1 8.38085629538338 294 246 134 256 241 324 204 347 434 233 329 233 M17597 GO_INHIBITORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INHIBITORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. 6/20 Gene Ontology CC GO:0060077 0.000226121646162907 0.000478748393707547 100 239 256 2.26144658408057e-05 9 0.932152918716796 0.932152918716796 1 4.31387003242259 96 256 541 314 360 86 9 129 416 284 138 234 M17786 GO_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME.html A vacuole to which materials ingested by endocytosis are delivered. 468/1101 Gene Ontology CC GO:0005768 2.40409665217731e-06 1.02930952959888e-05 430 287.090909090909 257 2.18554479937175e-07 120 1.47121371825348 -1.38423131409526 -1 10.2284663845217 426 257 165 295 120 217 474 425 244 182 353 235 M17731 GO_CILIARY_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PLASM.html All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. 34/119 Gene Ontology CC GO:0097014 0.0150150690137693 0.0233298652955879 250 262.636363636364 258 0.00137441248504194 152 1.41487757881632 1.00488311755193 1 3.21897958223164 176 405 249 353 335 152 156 261 249 295 258 236 M17251 GO_COMPACT_MYELIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPACT_MYELIN.html The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. 10/26 Gene Ontology CC GO:0043218 0.0240929777558093 0.0359441416895578 300 252.090909090909 261 0.00221463145901555 152 2.29162902302217 -2.29162902302217 -1 4.61401698647491 300 339 196 214 366 275 351 163 152 261 156 237 M17488 GO_VACUOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PART.html Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. 433/967 Gene Ontology CC GO:0044437 3.7721424262626e-06 1.43276129898761e-05 370 277.727272727273 261 3.4292262673018e-07 139 1.41082316873029 -1.31126758905801 -1 9.52614052646343 367 203 207 274 139 261 464 377 243 158 362 238 M17698 GO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS.html A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. 783/1929 Gene Ontology CC GO:0005794 2.7512452778499e-06 1.12781544013989e-05 275 293 262 2.75124868406359e-07 103 1.50113957016428 1.67568433616537 1 10.3534650906208 273 200 556 392 129 467 262 235 229 103 377 239 M17383 GO_ESCRT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_COMPLEX.html An endosomal sorting complex required for transport. 20/28 Gene Ontology CC GO:0036452 0.000787709601742279 0.00147345032300012 185 240.818181818182 264 7.1635616589217e-05 25 0.921931155077769 -0.727929734007207 -1 3.63911798485085 184 264 286 331 538 53 25 149 423 293 103 240 M17199 GO_HOPS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOPS_COMPLEX.html A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. 12/16 Gene Ontology CC GO:0030897 0.010485223784716 0.0166954802963246 135 257.909090909091 265 0.000957775679714861 125 0.849042445388904 -0.849042445388904 -1 2.10363644250667 125 265 345 291 347 131 132 138 402 494 167 241 M17625 GO_T_TUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_TUBULE.html Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. 26/87 Gene Ontology CC GO:0030315 6.98529294101965e-05 0.000166152235387216 545 342 266 6.35046794839217e-06 137 1.67483617015482 -1.29218377640939 -1 8.82392528857161 541 232 137 156 237 528 462 542 266 209 452 242 M17732 GO_SPERM_FLAGELLUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_FLAGELLUM.html A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. 28/88 Gene Ontology CC GO:0036126 0.0140350221213012 0.0219249805030056 395 272.545454545455 266 0.00128412429707832 80 0.924601613475447 0.947610181931142 1 2.13832044482629 136 410 266 437 461 112 80 165 393 395 143 243 M17344 GO_PHAGOCYTIC_CUP http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_CUP.html An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. 18/43 Gene Ontology CC GO:0001891 0.000228318597036217 0.000481635580609247 235 313.909090909091 267 2.07583905139156e-05 159 1.35943340745538 -1.66146719053125 -1 6.28631454784725 267 233 159 261 263 356 344 553 364 232 421 244 M17198 GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE.html The membrane surrounding the outer segment of a vertebrate photoreceptor. 6/19 Gene Ontology CC GO:0042622 0.000238615284784134 0.000501525944019017 185 289.454545454545 268 2.38640910421202e-05 107 1.72415943787674 -1.87808984816404 -1 7.93064665643975 424 185 463 152 268 442 498 107 181 149 315 245 M17232 GO_ORGANELLE_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. 301/618 Gene Ontology CC GO:0019866 0.000257496163546092 0.000533450833439574 455 316 269 2.34114824356354e-05 103 1.09042276613041 -0.859854325094563 -1 4.9748986753476 103 452 421 556 267 156 232 269 360 453 207 246 M17716 GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE.html A clathrin coat found on an endocytic vesicle. 9/17 Gene Ontology CC GO:0030128 0.00431392761520639 0.00731217056184543 320 323.181818181818 269 0.000432232505455974 188 0.804644505039319 0.804644505039319 1 2.395806431156 212 316 560 269 320 231 220 266 412 561 188 247 M17771 GO_RECYCLING_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME.html An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. 72/172 Gene Ontology CC GO:0055037 9.21199270734244e-05 0.000210455801772487 345 284.727272727273 269 8.37488950991735e-06 173 1.35291869799588 -1.35436284838152 -1 6.93429279711861 342 269 228 370 247 173 449 211 332 325 186 248 M17848 GO_VACUOLAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_MEMBRANE.html The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. 371/795 Gene Ontology CC GO:0005774 4.18886845115235e-06 1.54214392660259e-05 270 252.636363636364 269 3.80806947900862e-07 145 1.35456028208384 -1.28645948265815 -1 9.08591218198907 280 216 293 253 145 175 402 284 269 192 270 249 M17108 GO_GOLGI_STACK http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_STACK.html The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. 80/184 Gene Ontology CC GO:0005795 2.06324164213579e-05 5.59884351715723e-05 325 296.909090909091 270 1.87569181112331e-06 183 1.20337191754028 -1.10093043605055 -1 7.132453295102 322 398 270 422 209 188 453 183 371 256 194 250 M17090 GO_MHC_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. 19/50 Gene Ontology CC GO:0042611 0.0839184282471183 0.105675057792668 440 283.272727272727 271 0.00793650793650794 171 1.97809233338764 -1.74463954602475 -1 2.69131457008141 205 344 171 192 436 226 282 439 313 237 271 251 M17110 GO_SCF_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). 15/37 Gene Ontology CC GO:0019005 2.92478074879879e-05 7.58082185114663e-05 220 266.090909090909 271 2.65892693899744e-06 79 1.67024209768957 -1.24678293782493 -1 9.59317571481107 287 271 181 217 218 368 298 508 79 163 337 252 M17011 GO_INFLAMMASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMASOME_COMPLEX.html A cytosolic protein complex that is capable of activating caspase-1. 4/12 Gene Ontology CC GO:0061702 0.00887292840183362 0.0142459794896106 275 286.272727272727 272 0.000890855676608706 113 1.3220318064523 1.3220318064523 1 3.40252895076169 272 296 435 361 386 239 113 137 437 259 214 253 M17649 GO_CHROMATOID_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATOID_BODY.html A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). 5/15 Gene Ontology CC GO:0033391 0.0013924350312865 0.00249946412448322 235 259.727272727273 272 0.000139330829538746 6 3.12144353544104 3.12144353544104 1 11.3225482489196 232 297 548 140 462 338 295 96 6 272 171 254 M17054 GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of H4 histone acetyltransferase activity. 18/27 Gene Ontology CC GO:1902562 0.00337984222444577 0.00583148897232734 235 270.454545454545 273 0.000307731440380206 34 2.99445515760723 3.82650613950791 1 9.32609224302136 234 456 163 363 527 293 301 111 34 273 220 255 M17144 GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE.html The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 75/180 Gene Ontology CC GO:0031227 0.000321087343833734 0.000655789698713421 545 329.181818181818 273 2.91940196110396e-05 188 1.37812614928743 -1.10040312835422 -1 6.11524106210431 545 279 238 203 273 383 520 221 188 211 560 256 M17714 GO_CYTOPLASMIC_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE.html Any microtubule in the cytoplasm of a cell. 37/84 Gene Ontology CC GO:0005881 0.0056435929473387 0.00936789016275838 325 286.818181818182 273 0.000514374772022565 137 1.92982960208512 1.94883753678702 1 5.45656670463717 203 511 189 503 324 273 137 172 309 323 211 257 M17522 GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK.html The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. 537/1316 Gene Ontology CC GO:0042175 7.10137289058163e-07 4.84816826903543e-06 490 315.818181818182 276 7.10137515991e-08 59 1.36947858600761 -1.22277336950162 -1 10.145352973762 490 120 527 276 59 179 502 461 219 258 383 258 M17201 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX.html A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. 10/56 Gene Ontology CC GO:0008328 0.000173967176018912 0.000378018901274177 205 303.636363636364 277 1.58164485607787e-05 178 0.996423053470835 1.1593877491482 1 4.75380495059352 365 205 178 267 259 435 277 306 430 202 416 259 M17349 GO_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE.html Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. 196/498 Gene Ontology CC GO:0005874 2.73345900148138e-06 1.12781544013989e-05 280 278.090909090909 278 2.48496581614469e-07 125 1.31215367032974 1.51194630507883 1 9.05001605346175 283 309 219 393 125 411 244 176 278 278 343 260 M17439 GO_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a coated vesicle. 89/202 Gene Ontology CC GO:0030662 0.000453535453053036 0.000897751684467995 570 360.090909090909 278 4.12389979549429e-05 112 1.46427096828754 -1.48568441099932 -1 6.21909926874581 569 261 216 112 278 478 552 533 228 206 528 261 M17490 GO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION.html A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 994/2090 Gene Ontology CC GO:0005739 2.87629522051511e-06 1.17008509086416e-05 205 318.272727272727 278 2.87629894340528e-07 130 1.26791894802359 -1.04465665514283 -1 8.71668324255762 202 468 518 565 130 147 258 278 283 455 197 262 M17575 GO_AUTOPHAGOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_MEMBRANE.html The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. 19/34 Gene Ontology CC GO:0000421 0.000461700912607882 0.000910795656953432 285 251.272727272727 279 4.19816214099927e-05 124 1.11479368076545 -1.05311266799314 -1 4.72505259215989 259 285 308 324 279 221 124 134 254 281 295 263 M17624 GO_PSEUDOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOPODIUM.html A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. 14/28 Gene Ontology CC GO:0031143 1.09623210085681e-05 3.24934438100123e-05 485 271.454545454545 280 9.96579602982237e-07 41 1.34621762753111 -1.43311882251942 -1 8.42255272857126 484 80 162 41 191 428 506 328 280 153 333 264 M17582 GO_RECYCLING_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a recycling endosome. 18/51 Gene Ontology CC GO:0055038 0.0208930050677802 0.0313666413744855 320 293 281 0.00191764554564475 152 1.28233928801856 -1.39597157142623 -1 2.68764228038835 263 318 248 316 439 234 376 152 322 274 281 265 M17822 GO_PLATELET_DENSE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE.html Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. 13/31 Gene Ontology CC GO:0042827 0.00809169908258383 0.0131376462632962 235 296.818181818182 281 0.000738328624938476 147 1.93901984352818 1.40040836464215 1 5.08555402453064 231 254 147 280 327 314 281 391 398 184 458 266 M17101 GO_PERINUCLEAR_REGION_OF_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_REGION_OF_CYTOPLASM.html Cytoplasm situated near, or occurring around, the nucleus. 405/983 Gene Ontology CC GO:0048471 1.73962135217923e-07 2.13936413097786e-06 465 297.363636363636 283 1.58147408157958e-08 11 1.5241426990107 -1.42779870527594 -1 12.0459965389644 461 155 116 283 11 469 403 454 256 140 523 267 M17245 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX.html A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. 25/53 Gene Ontology CC GO:0016469 0.000499709529997998 0.000975784149793388 45 217 283 4.54384609523032e-05 44 0.914777956208316 -0.914777956208316 -1 3.8391162862348 45 341 371 320 283 56 44 121 320 386 100 268 M17578 GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). 22/36 Gene Ontology CC GO:0000315 0.078287984741032 0.105675057792668 105 307.909090909091 283 0.0073837372865804 104 0.63412846034273 -0.543674248726806 -1 0.86277018463928 104 283 388 344 364 169 223 267 448 550 247 269 M17431 GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of an organellar ribosome. 19/29 Gene Ontology CC GO:0000314 0.147522169018041 0.182586324823186 95 305.818181818182 284 0.0144050647743015 94 0.581031430781892 -0.581031430781892 -1 0.5981699779697 94 319 392 284 377 196 242 252 432 519 257 270 M17045 GO_SECRETORY_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE.html A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. 182/584 Gene Ontology CC GO:0030141 1.94946196705995e-06 9.08700820129558e-06 200 239.090909090909 285 1.77223972228866e-07 53 1.7070473888233 1.80937583849836 1 11.9968717012866 198 238 53 289 109 362 285 376 292 61 367 271 M17634 GO_IKAPPAB_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IKAPPAB_KINASE_COMPLEX.html A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 6/12 Gene Ontology CC GO:0008385 0.000473632184347884 0.000927997974756193 285 351.454545454545 285 4.73733161989887e-05 225 0.999221004206687 -0.694061737920384 -1 4.22387909329937 409 235 547 254 284 323 522 507 225 285 275 272 M17446 GO_VACUOLAR_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_LUMEN.html The volume enclosed within the vacuolar membrane. 75/197 Gene Ontology CC GO:0005775 8.94286146670462e-06 2.7494542168911e-05 185 335.272727272727 288 8.12990710825476e-07 143 1.59392021153667 -1.43739746994474 -1 10.133489718193 386 275 143 288 181 558 531 407 184 213 522 273 M17718 GO_PIGMENT_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE.html A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. 70/141 Gene Ontology CC GO:0048770 8.86186289247883e-06 2.73912125767527e-05 435 312 288 8.05627144483893e-07 160 1.82705384103205 -1.39994392929095 -1 11.6198222740545 527 288 160 186 179 319 516 435 173 214 435 274 M17401 GO_TCTN_B9D_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TCTN_B9D_COMPLEX.html A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins. 7/12 Gene Ontology CC GO:0036038 0.0255233010663164 0.0378268410675151 210 291.727272727273 289 0.00258212766972269 121 0.963010921741597 0.963010921741597 1 1.90918364874702 208 223 497 255 351 292 121 226 444 303 289 275 M17270 GO_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an endocytic vesicle. 102/230 Gene Ontology CC GO:0030666 3.27545944675595e-05 8.4142913787775e-05 320 288.454545454545 290 2.97773474026664e-06 117 1.52727364307518 1.6725422206381 1 8.67557866815054 316 274 142 117 221 458 323 422 290 196 414 276 M17418 GO_CELL_TRAILING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_TRAILING_EDGE.html The area of a motile cell opposite to the direction of movement. 7/27 Gene Ontology CC GO:0031254 0.00565639042699425 0.00936789016275838 210 282.363636363636 290 0.000567083985596617 126 6.00900434550934 6.00900434550934 1 16.9903774083189 209 380 502 311 431 290 141 126 159 304 253 277 M16986 GO_ENDOLYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME.html An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. 25/66 Gene Ontology CC GO:0036019 7.11951214022271e-06 2.33811250968678e-05 470 366.909090909091 291 6.47230470916228e-07 166 1.32859729648721 1.00025742143787 1 8.57702388847579 467 291 166 290 167 521 466 545 273 276 574 278 M16980 GO_AGGRESOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGGRESOME.html An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. 20/47 Gene Ontology CC GO:0016235 0.0839184282471183 0.105675057792668 340 275.636363636364 292 0.00793650793650794 85 1.62458849517356 -1.05290024730338 -1 2.21035115167187 308 338 167 340 373 184 221 433 85 291 292 279 M17354 GO_NUCLEAR_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EUCHROMATIN.html The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. 20/47 Gene Ontology CC GO:0005719 0.0329706336482061 0.0484911609380741 260 323.454545454545 292 0.0030432159547351 164 2.36644815240296 3.04536623586293 1 4.33570490001144 260 573 204 410 483 354 385 164 265 292 168 280 M17050 GO_SAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_COMPLEX.html A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. 3/9 Gene Ontology CC GO:0000124 0.000885976161343946 0.00164660521304438 225 287.272727272727 294 8.86329588865998e-05 86 0.33696007006734 -0.33696007006734 -1 1.30740920792334 221 294 440 310 542 123 93 86 468 471 112 281 M17127 GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinase (CDK) complex found in the nucleus. 10/20 Gene Ontology CC GO:0019908 0.000430152375112058 0.000863291919495728 290 281.454545454545 294 3.91124093792299e-05 68 1.8818988242565 -1.8818988242565 -1 8.03745462588932 289 383 298 332 460 232 263 68 294 340 137 282 M17313 GO_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 149/357 Gene Ontology CC GO:0005667 9.70221432273443e-06 2.93606276363377e-05 295 327.272727272727 294 8.82023373700815e-07 185 1.3696870683703 1.61315173313298 1 8.65345612207645 354 337 205 547 185 565 349 190 291 283 294 283 M17719 GO_EXTRINSIC_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 140/326 Gene Ontology CC GO:0019898 1.12053513234805e-06 6.47669306497173e-06 85 301.727272727273 294 1.01866882097751e-07 81 1.53937580463503 -1.37365662819459 -1 11.1340869337634 469 85 126 294 81 548 331 420 268 125 572 284 M17782 GO_PHOTORECEPTOR_DISC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_DISC_MEMBRANE.html Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment. 9/33 Gene Ontology CC GO:0097381 5.570155758301e-06 1.95124244139272e-05 575 333.545454545455 294 5.57016972033608e-07 129 1.46782859255716 1.1676092704129 1 9.63659049486757 496 129 571 131 161 572 386 294 279 139 511 285 M17357 GO_GLIAL_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_PROJECTION.html A prolongation or process extending from a glial cell. 7/32 Gene Ontology CC GO:0097386 0.00762590968393278 0.0124162698515863 210 259.818181818182 295 0.000765220630331002 22 2.6746509287177 2.6746509287177 1 7.1063709857812 206 260 492 22 329 295 359 316 123 302 154 286 M17583 GO_ORGANELLE_ENVELOPE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ENVELOPE_LUMEN.html The region between the inner and outer lipid bilayers of an organelle envelope. 61/115 Gene Ontology CC GO:0031970 0.000798931320373538 0.0014896203328255 185 287.363636363636 296 7.26565091231126e-05 140 0.870926315391784 -0.887607338290788 -1 3.43203301270929 140 340 394 472 296 149 181 203 382 419 185 287 M17185 GO_CLATHRIN_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT.html A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. 38/66 Gene Ontology CC GO:0030118 0.000143830732816057 0.000318187163177585 380 297 297 1.30763760896159e-05 181 0.827531778181114 -0.852438761182845 -1 4.03436856260876 250 376 369 366 256 181 297 201 380 398 193 288 M17577 GO_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_COMPLEX.html Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. 14/52 Gene Ontology CC GO:0030286 0.00159941147595987 0.0028357663592172 580 298.727272727273 297 0.000145506858300983 92 1.37086595951572 -1.76886564500976 -1 4.86783643186528 578 181 215 193 306 443 265 371 92 297 345 289 M17619 GO_CYTOPLASMIC_VESICLE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_VESICLE_PART.html Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. 331/882 Gene Ontology CC GO:0044433 3.42210983296828e-06 1.33647262395653e-05 470 318.909090909091 297 3.11101377826092e-07 89 1.54920191729715 -1.49957539145424 -1 10.5257478387772 466 231 89 224 134 545 369 528 297 110 515 290 M17049 GO_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEMBRANE.html The lipid bilayer surrounding any membrane-bounded vesicle in the cell. 295/700 Gene Ontology CC GO:0012506 4.77491464142739e-06 1.71422401412735e-05 135 314 298 4.34084091364436e-07 131 1.45426576762419 -1.39583093043504 -1 9.66156575891256 562 213 131 201 152 463 411 466 298 134 423 291 M17015 GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK.html A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. 10/15 Gene Ontology CC GO:0071782 0.00103643016816373 0.00191391896868573 545 353.636363636364 299 9.42653415894507e-05 172 0.911139980086621 1.11836643864368 1 3.45225303232483 542 172 294 231 299 451 570 257 240 339 495 292 M17055 GO_ZYMOGEN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_GRANULE.html A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. 7/28 Gene Ontology CC GO:0042588 7.59330438411763e-06 2.45191616425698e-05 540 332 299 7.59333033046456e-07 99 1.06789437459933 -1.56923278412938 -1 6.86327890102837 531 99 442 155 178 539 540 216 199 299 454 293 M17191 GO_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_COMPLEX.html A protein complex which is capable of protein kinase activity. 50/131 Gene Ontology CC GO:1902911 6.62463254212532e-05 0.00015888122860367 330 296.727272727273 299 6.02257457385974e-06 218 1.28878997897218 1.39375455998258 1 6.82494250647725 299 330 244 360 235 427 329 268 218 314 240 294 M17833 GO_ORGANELLE_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_SUBCOMPARTMENT.html A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. 187/420 Gene Ontology CC GO:0031984 2.11171194190776e-06 9.6107834836432e-06 405 312.636363636364 299 1.91973997170677e-07 113 1.31437373182593 -1.21510468820544 -1 9.19262838336375 404 208 240 380 113 287 562 398 303 245 299 295 M17224 GO_AXON_INITIAL_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_INITIAL_SEGMENT.html Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. 7/26 Gene Ontology CC GO:0043194 0.00126630924431116 0.00230165642519451 330 277.272727272727 300 0.000126703141615327 94 1.55645248742676 -1.55645248742676 -1 5.72347569593318 330 320 471 234 332 266 305 94 237 300 161 296 M17689 GO_DENDRITE_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_CYTOPLASM.html All of the contents of a dendrite, excluding the surrounding plasma membrane. 13/26 Gene Ontology CC GO:0032839 1.75928003326124e-05 4.88876855396633e-05 485 346.909090909091 300 1.59935827445603e-06 191 1.14959856971694 -0.777701009155557 -1 6.90812191109998 482 241 206 191 202 497 452 492 300 288 465 297 M17841 GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT.html A distinct region of the endoplasmic reticulum 10/22 Gene Ontology CC GO:0098827 0.00103643016816373 0.00191391896868573 545 354.727272727273 300 9.42653415894507e-05 173 0.911139980086621 1.11836643864368 1 3.45225303232483 543 173 295 232 300 452 571 254 241 345 496 298 M17209 GO_NPBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NPBAF_COMPLEX.html A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. 9/15 Gene Ontology CC GO:0071564 0.0150709688527574 0.0233539410104391 245 300 301 0.00151741655776934 108 0.662310073571786 0.662310073571786 1 1.50640412143464 243 234 469 301 337 168 108 349 375 498 218 299 M17586 GO_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MEMBRANE.html The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. 121/257 Gene Ontology CC GO:0019867 0.000271860921464665 0.000559201468350806 270 330.454545454545 301 2.47176838170139e-05 245 1.32221290353901 1.58999050198055 1 5.99467201994567 301 329 259 416 270 470 264 473 245 270 338 300 M17051 GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the cytoplasm. 8/16 Gene Ontology CC GO:0000153 0.0011747566854454 0.00214876381071975 85 270 302 0.000117537817186043 81 0.769233880183894 -0.769233880183894 -1 2.8606805379777 142 302 441 401 398 81 84 91 469 472 89 301 M17640 GO_ESC_E_Z_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESC_E_Z_COMPLEX.html A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. 13/20 Gene Ontology CC GO:0035098 0.0839184282471183 0.105675057792668 290 326.636363636364 302 0.00793650793650794 200 2.24769210770565 2.24769210770565 1 3.05812141923336 201 381 200 330 567 315 286 443 281 287 302 302 M17734 GO_ESCRT_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_III_COMPLEX.html An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. 8/12 Gene Ontology CC GO:0000815 0.00755330726525186 0.0123328011280101 565 292.181818181818 303 0.000757910436097571 63 0.553187755737887 -0.553187755737887 -1 1.47204227383553 159 332 562 303 354 85 63 135 529 562 130 303 M17701 GO_PERICENTRIOLAR_MATERIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIOLAR_MATERIAL.html A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. 11/25 Gene Ontology CC GO:0000242 0.000136821717995748 0.000305339586878542 525 345.090909090909 305 1.24391116282338e-05 200 1.20082626528998 1.3623684335917 1 5.88420988497535 523 230 252 226 255 522 377 305 200 355 551 304 M17305 GO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MATRIX.html The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. 262/496 Gene Ontology CC GO:0005759 0.00024154718625699 0.000505848817596161 230 313.545454545455 306 2.19612464371268e-05 126 1.17463883896287 -0.926237598640391 -1 5.39690380687923 126 431 413 522 265 162 229 317 306 448 230 305 M17473 GO_INTERSTITIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTITIAL_MATRIX.html A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. 7/18 Gene Ontology CC GO:0005614 6.91140576175792e-06 2.29585777603223e-05 170 313.545454545455 307 6.91142725724032e-07 83 2.02894942798944 -2.084341423538 -1 13.1206877090399 419 83 513 151 170 479 307 490 197 168 472 306 M17566 GO_GAMMA_TUBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_COMPLEX.html A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. 7/25 Gene Ontology CC GO:0000930 0.0654523737558387 0.0941081393802856 365 300.272727272727 307 0.00674640900715729 37 2.37157607017391 2.37157607017391 1 3.39311084356161 207 362 536 264 390 363 428 222 37 307 187 307 M17717 GO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOST.html Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. 7/20 Gene Ontology CC GO:0018995 8.69879688044886e-05 0.000200314924179261 425 338.636363636364 308 8.69913741001185e-06 218 1.42973242219723 -0.798545242303753 -1 7.37074170623212 421 218 561 259 248 500 413 245 308 229 323 308 M17169 GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. 35/63 Gene Ontology CC GO:0030660 0.000115651020892371 0.000261118320608555 310 324.272727272727 309 1.05142819052186e-05 251 1.01949577806265 -0.875621487386512 -1 5.09222758391568 353 290 309 293 251 285 393 428 404 310 251 309 M17290 GO_INVADOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_INVADOPODIUM.html A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. 7/17 Gene Ontology CC GO:0071437 0.160527319099363 0.196162347652076 260 333.454545454545 309 0.0173459312054636 199 1.69399264736948 1.69399264736948 1 1.67040895013629 258 435 484 319 422 309 199 264 446 301 231 310 M17295 GO_CILIARY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PART.html Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 146/415 Gene Ontology CC GO:0044441 6.8062490781503e-05 0.000162562477982268 230 287.727272727273 309 6.18769059597575e-06 134 1.14541792799067 1.00212607715675 1 6.04981514316541 227 225 351 309 236 176 134 525 314 337 331 311 M17451 GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. 37/89 Gene Ontology CC GO:0012507 0.07773072357209 0.105675057792668 365 285.090909090909 310 0.00732919505379913 187 1.81859161576614 -2.15777454046597 -1 2.47430416710085 266 364 191 188 362 311 350 397 187 210 310 312 M17564 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. 49/112 Gene Ontology CC GO:0033116 0.0040557713870349 0.00693560905830228 410 325 310 0.00036938797162577 100 2.04572320875906 2.33507509993612 1 6.15656326394735 407 310 152 252 317 557 566 239 100 174 501 313 M17774 GO_COATED_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_MEMBRANE.html A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. 59/109 Gene Ontology CC GO:0048475 0.000199165716370492 0.000427947152647377 255 285.727272727273 310 1.81076135547874e-05 117 0.908019755369834 -0.834045614301202 -1 4.26384945007606 251 322 382 338 261 117 310 276 363 370 153 314 M17172 GO_LIPID_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE.html An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. 41/94 Gene Ontology CC GO:0005811 0.00196022317778782 0.00343336059624654 380 305.181818181818 311 0.000178361085373698 156 1.5729669112231 -1.51232052555832 -1 5.40338101169433 380 404 172 448 311 228 442 208 288 156 320 315 M17385 GO_CILIARY_TRANSITION_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TRANSITION_ZONE.html A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition. 15/25 Gene Ontology CC GO:0035869 0.00419836643633766 0.00713722294177402 280 314.272727272727 311 0.00038239998664697 193 0.88812303321085 0.88812303321085 1 2.65738177027853 279 253 325 292 318 307 193 311 440 383 356 316 M17064 GO_DNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_COMPLEX.html A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. 8/13 Gene Ontology CC GO:0042575 0.00410169192634146 0.00699344523134326 195 297.727272727273 312 0.000410928239632163 118 0.676451708310362 -0.676451708310362 -1 2.03236705970039 193 312 443 356 468 148 126 118 479 474 158 317 M17288 GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex that possesses activity that prevents or downregulates transcription. 35/99 Gene Ontology CC GO:0017053 0.00121618685664617 0.00221752682379018 280 323.636363636364 313 0.000110623609125777 157 0.970170753786552 -1.06854214429853 -1 3.58943754007798 277 454 313 529 301 157 231 342 383 391 182 318 M17623 GO_ACROSOMAL_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_VESICLE.html A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. 44/154 Gene Ontology CC GO:0001669 8.06815546588324e-06 2.52856718011548e-05 340 310.181818181818 314 7.33471368611982e-07 176 1.39376236658668 1.45800282144041 1 8.93163458031497 337 314 195 424 176 348 292 442 367 219 298 319 M17097 GO_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_PIT.html A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. 42/85 Gene Ontology CC GO:0005905 0.000135894602625529 0.000304446047742465 455 379.181818181818 315 1.23548179634864e-05 229 1.3291041482597 -1.50986541911181 -1 6.5151468560446 452 299 315 229 253 523 472 558 259 242 569 320 M17503 GO_SPERM_MIDPIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MIDPIECE.html The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. 8/16 Gene Ontology CC GO:0097225 0.0015952399882099 0.0028357663592172 135 279.727272727273 315 0.000159638630230091 32 0.801545350435125 0.801545350435125 1 2.84622402283389 135 350 522 315 352 120 32 132 460 536 123 321 M17381 GO_CLATHRIN_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_VESICLE_COAT.html A clathrin coat found on a vesicle. 20/32 Gene Ontology CC GO:0030125 3.63619215169255e-06 1.4011460424522e-05 335 277 316 3.30563469241635e-07 136 0.821321334673183 -0.824656700599956 -1 5.55680905689231 333 171 323 141 136 316 304 333 339 402 249 322 M17475 GO_CYTOPLASMIC_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_DYNEIN_COMPLEX.html Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. 8/29 Gene Ontology CC GO:0005868 0.00368264313833844 0.0063162247298505 320 305.090909090909 316 0.000368876024756455 165 1.03628862306728 -1.41654306777924 -1 3.17737826883376 435 165 515 282 316 260 185 173 337 318 370 323 M17663 GO_INTERCELLULAR_BRIDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCELLULAR_BRIDGE.html A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. 31/52 Gene Ontology CC GO:0045171 0.000186990688301637 0.000404796321491933 325 277.454545454545 317 1.70005985100152e-05 47 0.816762098687303 -0.862094338575036 -1 3.86282474679259 244 325 317 492 321 80 234 140 425 427 47 324 M17132 GO_MITOTIC_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE.html A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. 33/75 Gene Ontology CC GO:0072686 0.0839184282471183 0.105675057792668 225 332.545454545455 321 0.00793650793650794 197 1.16125386425287 1.28498821158908 1 1.57995627652435 225 300 197 321 514 417 342 295 394 290 363 325 M17713 GO_SWI_SNF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_COMPLEX.html A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. 8/15 Gene Ontology CC GO:0016514 0.00455435498571777 0.00763019472969528 570 346.090909090909 322 0.000456371596526029 145 1.06883965713336 0.662310073571786 1 3.15489216330265 567 164 559 219 322 569 324 145 158 320 460 326 M17505 GO_SECRETORY_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_MEMBRANE.html The lipid bilayer surrounding a secretory granule. 44/123 Gene Ontology CC GO:0030667 0.00511672310350707 0.00852295663927115 300 310.181818181818 323 0.000466242035079624 107 1.69562516431566 2.00586456838301 1 4.89138883703162 296 239 107 272 323 465 439 340 361 145 425 327 M17708 GO_BAF_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BAF_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family. 11/23 Gene Ontology CC GO:0090544 0.0137879785182949 0.0215974297657844 425 310.727272727273 323 0.00126137793567672 177 1.06883965713336 0.662310073571786 1 2.48163883340847 422 214 247 225 333 370 177 323 258 356 493 328 M17017 GO_PHOSPHATASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_COMPLEX.html A protein complex which is capable of phosphatase activity. 21/58 Gene Ontology CC GO:1903293 0.000250456053977132 0.000522612271475749 405 290.909090909091 324 2.27713246687679e-05 55 1.25241463873339 1.25241463873339 1 5.72952733624234 211 395 324 348 405 283 183 361 231 404 55 329 M17235 GO_GOLGI_CISTERNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA.html Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. 61/145 Gene Ontology CC GO:0031985 0.00180837437051885 0.00317702245033402 230 328.636363636364 324 0.000164532958730382 226 1.244510991858 -1.08435446872892 -1 4.3335468262835 399 356 226 341 309 289 524 324 374 230 243 330 M17571 GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX.html RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 9/21 Gene Ontology CC GO:0005666 0.0017994494286618 0.00317098100538574 145 259 324 0.000180090819963737 98 0.91343148314624 -0.91343148314624 -1 3.1817380831033 145 324 538 336 374 98 110 104 356 332 132 331 M17167 GO_PORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX.html Any small opening in a membrane that allows the passage of gases and/or liquids. 11/21 Gene Ontology CC GO:0046930 0.0431170777819734 0.0630928378683054 495 358.181818181818 325 0.00399873217905572 176 0.880577768047831 -0.880577768047831 -1 1.47303144077467 325 476 269 493 452 186 314 303 455 491 176 332 M17403 GO_GOLGI_ASSOCIATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE.html Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. 60/113 Gene Ontology CC GO:0005798 4.95981853979097e-05 0.00012199043046805 230 312.454545454545 325 4.50902760053892e-06 190 1.10009034093648 -0.961647853763137 -1 6.0016252749907 329 390 365 275 229 190 456 325 354 298 226 333 M17832 GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the nucleus. 24/47 Gene Ontology CC GO:0000152 0.256791963142608 0.300456993312606 310 411.363636363636 325 0.0266192271391569 247 0.580134101476325 -0.580134101476325 -1 0.42231427809858 306 535 311 543 563 278 325 247 557 576 284 334 M17539 GO_DNA_HELICASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_COMPLEX.html A protein complex that possesses DNA helicase activity. 12/18 Gene Ontology CC GO:0033202 0.26811890745451 0.312445017154651 230 352.454545454545 326 0.027977290311535 192 0.54209528580132 -0.54209528580132 -1 0.381783762861275 230 373 326 440 409 268 192 307 505 540 287 335 M17748 GO_MITOCHONDRIAL_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PROTEIN_COMPLEX.html A protein complex that is part of a mitochondrion. 75/156 Gene Ontology CC GO:0098798 0.00645380285427302 0.0105974376413915 295 379.181818181818 326 0.00058843759170359 146 0.574872674835986 -0.574872674835986 -1 1.58252446501526 146 529 416 568 326 244 271 293 520 565 293 336 M17272 GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. 2/14 Gene Ontology CC GO:0017146 0.0156207053430595 0.0241410900756374 215 319.1 327 0.00174780349290532 156 1.38040838385514 1.38040838385514 1 3.11199398315701 448 219 481 NA 341 375 214 156 429 215 313 337 M17452 GO_SPINDLE_MIDZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MIDZONE.html The area in the center of the spindle where the spindle microtubules from opposite poles overlap. 10/32 Gene Ontology CC GO:0051233 0.0660835028239932 0.0945452094858121 245 339.818181818182 327 0.00619602029723219 222 1.03624433252004 1.03624433252004 1 1.47969026993647 241 450 229 467 357 327 317 286 499 343 222 338 M17551 GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX.html RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 6/15 Gene Ontology CC GO:0005736 0.139671859645702 0.173987790679344 250 341.727272727273 327 0.0149315426681919 166 0.669270521713079 -0.669270521713079 -1 0.708556619905726 247 327 534 350 384 199 166 250 478 545 279 339 M17048 GO_OXIDOREDUCTASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_COMPLEX.html Any protein complex that possesses oxidoreductase activity. 56/106 Gene Ontology CC GO:1990204 0.00814918005048033 0.0131939105579205 165 314.363636363636 328 0.000743593044958233 162 0.998038889465894 -0.876626984976487 -1 2.61501907408657 162 464 380 482 328 163 189 287 415 410 178 340 M17146 GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX.html A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. 7/13 Gene Ontology CC GO:0043240 0.107276887740404 0.134503342980377 305 365.090909090909 328 0.0112837367452855 202 0.53695629697682 -0.53695629697682 -1 0.652147723682367 240 304 456 444 473 305 328 202 461 487 316 341 M17264 GO_ENDOPLASMIC_RETICULUM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_PART.html Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. 607/1512 Gene Ontology CC GO:0044432 7.38416857552129e-07 4.96284818215268e-06 525 312.363636363636 328 7.38417102918997e-08 36 1.52068537013406 -1.2705340073238 -1 11.2439980662722 525 36 480 206 64 328 546 417 165 117 552 342 M17440 GO_SMOOTH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_ENDOPLASMIC_RETICULUM.html The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. 23/64 Gene Ontology CC GO:0005790 0.0839184282471183 0.105675057792668 475 349.909090909091 328 0.00793650793650794 200 1.24446678606768 -1.37577472987808 -1 1.69317250504987 475 522 290 328 428 264 233 200 384 407 318 343 M17679 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE.html A cellular membrane associated with the pre-autophagosomal structure. 15/18 Gene Ontology CC GO:0034045 0.161385165508919 0.196380264556117 415 354 329 0.0158730158730159 224 1.02002732447308 1.02002732447308 1 1.00514089830328 224 505 329 466 415 300 227 309 413 385 321 344 M17413 GO_SIN3_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_TYPE_COMPLEX.html Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. 9/22 Gene Ontology CC GO:0070822 0.00107563147594395 0.0019736983907797 500 316.636363636364 331 0.000107615247328211 49 0.811579176312201 -0.811579176312201 -1 3.05991194037268 327 497 500 453 463 146 49 170 464 331 83 345 M17140 GO_GEMINI_OF_COILED_BODIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_GEMINI_OF_COILED_BODIES.html Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). 8/11 Gene Ontology CC GO:0097504 0.0797000693932244 0.105675057792668 275 365.545454545455 332 0.00827116914028781 274 0.789619679568588 -0.789619679568588 -1 1.07432542180263 274 308 455 378 370 312 318 322 466 486 332 346 M17242 GO_COPI_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a COPI-coated vesicle. 11/20 Gene Ontology CC GO:0030663 0.161385165508919 0.196380264556117 270 346.727272727273 332 0.0158730158730159 266 1.29751163917361 -1.20189349116474 -1 1.27857558238618 332 365 296 379 395 288 266 509 405 268 311 347 M17436 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_.html All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. 8/16 Gene Ontology CC GO:0045263 0.18549432058022 0.222901699158767 230 343.636363636364 332 0.0203083383634337 178 0.390515569100679 -0.390515569100679 -1 0.354867482832446 226 374 504 317 397 200 178 332 492 521 239 348 M17176 GO_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COAT.html A membrane coat found on a coated vesicle. 31/55 Gene Ontology CC GO:0030120 2.72083255572815e-05 7.14836916914031e-05 565 383.090909090909 333 2.4735147327197e-06 215 1.00777871151435 -0.88752949902742 -1 5.82409764492769 561 240 333 215 216 468 550 556 319 324 432 349 M17502 GO_STAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAGA_COMPLEX.html A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. 6/17 Gene Ontology CC GO:0030914 0.012975774818653 0.0204359614310121 255 329.363636363636 334 0.00130521702166902 165 0.826105627352758 -0.826105627352758 -1 1.94570318508761 252 355 521 364 334 208 165 197 488 535 204 350 M17598 GO_MICROTUBULE_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_END.html Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. 14/27 Gene Ontology CC GO:1990752 0.180002729374527 0.216753286621826 190 344.272727272727 337 0.0178795271293272 190 1.44570096457758 1.44570096457758 1 1.33821171029994 190 495 217 441 531 257 243 337 463 379 234 351 M17422 GO_MLL1_2_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MLL1_2_COMPLEX.html A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. 14/35 Gene Ontology CC GO:0044665 0.412023084947393 0.467876901963837 290 394.272727272727 338 0.0471319781862963 252 0.488494915114496 -0.488494915114496 -1 0.224624176777535 290 523 338 521 429 252 284 326 566 518 290 352 M17441 GO_ENDORIBONUCLEASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_COMPLEX.html A protein complex which is capable of endoribonuclease activity. 11/22 Gene Ontology CC GO:1902555 0.0839184282471183 0.105675057792668 340 368.909090909091 338 0.00793650793650794 255 0.817827137870305 -0.817827137870305 -1 1.11270338012404 271 426 337 475 413 329 338 255 392 522 300 353 M17023 GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 10/21 Gene Ontology CC GO:0031362 0.0177999122264066 0.0272178552033414 360 327.272727272727 339 0.00163141651937679 116 1.5608663113425 0.869334340353145 1 3.40546513698955 357 116 135 250 339 430 431 546 325 200 471 354 M17396 GO_SAGA_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_TYPE_COMPLEX.html A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. 11/36 Gene Ontology CC GO:0070461 0.000784370458584794 0.00147196793851302 295 338.727272727273 339 7.1331841040104e-05 241 1.18308504832356 -0.826105627352758 -1 4.67068579541938 387 292 283 343 295 302 241 481 409 354 339 355 M17338 GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX.html A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. 5/19 Gene Ontology CC GO:0033276 0.000225306360160041 0.000478748393707547 270 348 340 2.25329206750347e-05 207 1.18308504832356 -0.826105627352758 -1 5.47514795872387 415 207 488 300 266 340 267 524 400 271 350 356 M17563 GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR.html A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. 14/26 Gene Ontology CC GO:0030687 0.250876098319245 0.29413059802946 220 375 340 0.0259173975436964 186 0.564703027248038 -0.564703027248038 -1 0.418356312639673 217 460 340 510 488 220 186 300 547 548 309 357 M17470 GO_AXONEME_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_PART.html Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 7/32 Gene Ontology CC GO:0044447 0.00872713397360242 0.0140509287931538 485 369 341 0.000876159790554463 155 1.72064247838273 0.998733349080819 1 4.44279870475089 481 287 512 218 330 386 341 572 155 227 550 358 M17430 GO_SYNAPTONEMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX.html A proteinaceous scaffold found between homologous chromosomes during meiosis. 21/151 Gene Ontology CC GO:0000795 0.207106651851302 0.24681988612382 215 346.272727272727 342 0.0208759757212342 176 0.892464331775903 0.888727210494804 1 0.75592488970696 214 493 251 497 423 207 176 319 482 405 342 359 M17838 GO_CHYLOMICRON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHYLOMICRON.html A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. 5/15 Gene Ontology CC GO:0042627 0.0180538493010677 0.0275333110712853 375 306.727272727273 343 0.00182022223117786 53 1.77515081236257 2.12158125217247 1 3.86060269772718 371 118 577 160 343 487 551 237 53 131 346 360 M17611 GO_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUCHROMATIN.html A dispersed and relatively uncompacted form of chromatin. 25/56 Gene Ontology CC GO:0000791 0.0839184282471183 0.105675057792668 345 381.909090909091 344 0.00793650793650794 208 2.36644815240296 3.04536623586293 1 3.21969622278564 344 572 208 430 450 502 512 214 343 335 291 361 M17759 GO_MEDIATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEDIATOR_COMPLEX.html A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. 19/36 Gene Ontology CC GO:0016592 0.000189262026075707 0.000408184518924472 345 335.636363636364 344 1.72071190824719e-05 236 0.84609719352947 -1.01887029070857 -1 3.99729368427298 315 360 355 382 260 343 505 236 344 347 245 362 M17367 GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 18/32 Gene Ontology CC GO:0031312 0.014573435745363 0.0227047058243122 285 348.181818181818 345 0.00133371629941477 143 0.854373576485107 -0.854373576485107 -1 1.95782942364135 281 345 305 395 509 294 460 143 498 397 203 363 M17683 GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. 24/80 Gene Ontology CC GO:0031463 0.000602132202014962 0.00114862182430577 345 306.818181818182 345 5.475427878544e-05 76 1.44049237465855 1.47004174717544 1 5.90320667577841 345 342 257 434 368 384 238 76 196 380 355 364 M17477 GO_ENDOLYSOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME_MEMBRANE.html The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. 19/50 Gene Ontology CC GO:0036020 9.59278194621591e-06 2.91822524469094e-05 520 373.818181818182 346 8.72074888582736e-07 184 1.07416233378735 0.750904864377257 1 6.79034256263654 519 326 242 247 184 555 528 357 267 346 541 365 M17638 GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. 12/29 Gene Ontology CC GO:0080008 0.0202540070984633 0.0305660994854094 165 307.727272727273 347 0.00185844656652803 100 0.500356057454587 -0.500356057454587 -1 1.05652265805618 164 378 347 405 480 100 111 191 502 555 152 366 M17099 GO_RNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_COMPLEX.html Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. 63/133 Gene Ontology CC GO:0030880 0.000574664689697131 0.00110718730214981 425 357.181818181818 348 5.22558957709479e-05 183 1.27903133665673 -0.856562438617981 -1 5.26998016300048 270 425 386 520 287 272 316 498 183 424 348 367 M17239 GO_GOLGI_APPARATUS_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS_PART.html Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. 496/1202 Gene Ontology CC GO:0044431 6.07311728327499e-06 2.0648598763135e-05 390 332.909090909091 348 5.52103095293433e-07 160 1.48838246466067 -1.35585337632284 -1 9.72053425496123 388 224 168 351 160 571 348 503 247 165 537 368 M17286 GO_ORGANELLAR_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_RIBOSOME.html A ribosome contained within a subcellular membrane-bounded organelle. 52/80 Gene Ontology CC GO:0000313 0.08106524866958 0.105675057792668 55 309.181818181818 348 0.00765601127768374 55 0.63609262200747 -0.606159458320466 -1 0.865442545746743 55 348 409 375 367 177 253 238 426 507 246 369 M17617 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE.html The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 27/59 Gene Ontology CC GO:0098573 0.00488813073752852 0.00816572128985979 405 345.181818181818 348 0.000445365951847784 120 1.0919031479686 -1.17036396768369 -1 3.17812952340599 401 472 339 566 447 167 302 120 391 348 244 370 M17135 GO_CELL_PROJECTION_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_CYTOPLASM.html All of the contents of a cell projection, excluding the plasma membrane surrounding the projection. 35/73 Gene Ontology CC GO:0032838 2.47747451724133e-06 1.05260953466669e-05 475 384.272727272727 349 2.25225209744652e-07 121 1.16712906857405 1.40728612109213 1 8.09853212919118 471 331 289 304 121 551 448 529 345 349 489 371 M17498 GO_PRP19_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRP19_COMPLEX.html A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. 12/20 Gene Ontology CC GO:0000974 0.179938416790226 0.216753286621826 535 366.727272727273 350 0.017872524838386 240 0.682837997838337 -0.682837997838337 -1 0.632068307123515 350 477 342 240 382 256 306 353 533 533 262 372 M17584 GO_SPINDLE_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MICROTUBULE.html Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. 35/78 Gene Ontology CC GO:0005876 0.0839184282471183 0.105675057792668 305 354.909090909091 350 0.00793650793650794 183 1.58189576613053 1.90625732352268 1 2.15226510370842 304 371 183 339 547 415 407 270 326 350 392 373 M17071 GO_U2_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. 18/43 Gene Ontology CC GO:0005684 0.00455038585999547 0.00763019472969528 550 354.545454545455 352 0.000414529547975099 119 0.729513075224341 -0.729513075224341 -1 2.15330246148017 235 536 352 549 516 151 250 119 550 477 165 374 M17391 GO_MICROTUBULE_PLUS_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_PLUS_END.html The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. 11/22 Gene Ontology CC GO:0035371 0.210223434866896 0.250018817598901 165 321.545454545455 353 0.021226496729063 165 1.44570096457758 1.44570096457758 1 1.2132505396985 165 400 187 403 506 246 209 369 458 353 241 375 M17455 GO_NUCLEAR_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE_PART.html Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. 7/16 Gene Ontology CC GO:0044453 0.0765897756730953 0.105675057792668 510 388.454545454545 353 0.00793650793650794 292 2.1380527310452 2.1380527310452 1 2.90895039563909 292 506 506 397 517 332 353 409 342 305 314 376 M17036 GO_NUCLEAR_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE.html The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. 9/30 Gene Ontology CC GO:0005640 0.400222293207817 0.45537103439787 330 361.818181818182 354 0.0498349932072483 255 0.764504843011521 -1.0132607264513 -1 0.364080881186286 324 293 438 354 400 389 255 327 445 327 428 377 M17087 GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX.html The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. 8/15 Gene Ontology CC GO:0008540 0.231220412485837 0.272745711054722 285 362.454545454545 355 0.0259523916043839 244 0.807585301641838 -0.807585301641838 -1 0.635198825097762 284 346 447 355 396 299 363 244 509 478 266 378 M17443 GO_NUCLEAR_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. 29/73 Gene Ontology CC GO:0005637 0.154520617971777 0.189624027999336 300 388.181818181818 356 0.0151433948667497 221 1.7129875316718 1.7129875316718 1 1.72429423619286 297 570 356 489 560 341 274 336 427 399 221 379 M17506 GO_DNA_PACKAGING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING_COMPLEX.html A protein complex that plays a role in the process of DNA packaging. 50/109 Gene Ontology CC GO:0044815 0.424350631552297 0.479052080150835 360 348.363636363636 357 0.0489656906011314 106 0.943590204460199 -0.933866109524515 -1 0.420406533774827 106 357 239 429 407 344 412 335 456 390 357 380 M17111 GO_CD40_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD40_RECEPTOR_COMPLEX.html A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. 9/16 Gene Ontology CC GO:0035631 0.143646306712929 0.178170740944363 275 337.454545454545 358 0.0153875623073811 203 1.59097666625471 -1.15425804175272 -1 1.66148462345335 428 273 450 273 379 310 203 387 403 248 358 381 M17168 GO_LUMENAL_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUMENAL_SIDE_OF_MEMBRANE.html Any side (leaflet) of a membrane that faces the lumen of an organelle. 26/66 Gene Ontology CC GO:0098576 0.0839184282471183 0.105675057792668 380 334.636363636364 358 0.00793650793650794 173 1.69342199292789 -1.52799267582725 -1 2.30400330138618 379 419 173 216 437 317 308 457 358 208 409 382 M17637 GO_LYTIC_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE.html A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. 310/770 Gene Ontology CC GO:0000323 1.4103938620007e-06 7.40372526308368e-06 460 323.909090909091 359 1.28217706017114e-07 90 1.35698105231481 -1.27811921366613 -1 9.70495521532116 510 142 157 359 90 379 538 459 304 166 459 383 M17112 GO_BLOC_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_1_COMPLEX.html A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. 4/16 Gene Ontology CC GO:0031083 0.111870588173724 0.139959307282278 420 362.181818181818 360 0.011793684083783 206 0.574762572684831 -0.574762572684831 -1 0.684228661263707 417 336 451 257 403 360 334 206 411 483 326 384 M17528 GO_SCHMIDT_LANTERMAN_INCISURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHMIDT_LANTERMAN_INCISURE.html Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. 7/21 Gene Ontology CC GO:0043220 0.0765897756730953 0.105675057792668 480 381.636363636364 361 0.00793650793650794 287 1.98057969718709 -1.98057969718709 -1 2.69469877943499 479 334 529 287 387 409 478 292 336 306 361 385 M17724 GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX.html Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. 26/50 Gene Ontology CC GO:0008023 0.00819464996308501 0.013230468376154 265 312.909090909091 361 0.000747757623615632 131 1.0669820580816 -1.1744481889461 -1 2.79387371488024 265 377 361 508 459 153 226 131 389 413 160 386 M17107 GO_SMN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_COMPLEX.html A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. 9/13 Gene Ontology CC GO:0032797 0.0658217450246103 0.094404388645719 350 392.363636363636 363 0.00678567341677044 331 0.789619679568588 -0.789619679568588 -1 1.12823865124835 331 349 449 439 361 358 346 363 470 482 368 387 M17610 GO_PHOTORECEPTOR_INNER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_INNER_SEGMENT.html The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. 21/55 Gene Ontology CC GO:0001917 0.0781543430933308 0.105675057792668 435 336.363636363636 363 0.00737065430732166 143 1.50162941286737 -1.7097497369556 -1 2.04305786046107 434 306 175 302 363 447 143 384 408 254 484 388 M17258 GO_CYTOSOLIC_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PROTEASOME_COMPLEX.html A proteasome complex found in the cytosol of a cell. 7/14 Gene Ontology CC GO:0031597 0.567399726195653 0.625872217063144 365 397.363636363636 365 0.0803794257066422 317 0.648609903281612 -0.648609903281612 -1 0.184006973770035 317 321 478 365 416 339 365 451 473 505 341 389 M17590 GO_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SUBUNIT.html Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. 109/272 Gene Ontology CC GO:0044391 0.0305426241231131 0.0450347876101005 490 328.818181818182 365 0.00281591606099624 110 0.587834030652013 -0.552538801258848 -1 1.10331975538752 110 488 423 490 365 111 112 280 507 552 179 390 M17808 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX.html A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. 14/28 Gene Ontology CC GO:0045259 0.158845283361691 0.194518164794613 195 341.727272727273 365 0.0156024255001062 186 0.390515569100679 -0.390515569100679 -1 0.387068720626862 186 412 391 333 380 193 191 365 485 573 250 391 M16983 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. 7/18 Gene Ontology CC GO:0034362 7.89754375311484e-05 0.000184063721342757 370 287.090909090909 366 7.89782443754214e-06 25 1.9167547335483 1.94911888888319 1 9.97968195880414 462 32 429 92 245 554 368 366 25 79 506 392 M16987 GO_90S_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_90S_PRERIBOSOME.html A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 15/28 Gene Ontology CC GO:0030686 0.306758778510588 0.35461314795824 280 391 366 0.0327584517922627 218 0.178855229770702 -0.19613519574558 -1 0.112255165931769 278 496 366 514 576 218 293 272 562 463 263 393 M17369 GO_PLATELET_DENSE_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet dense granule. 7/15 Gene Ontology CC GO:0031089 0.018816830063494 0.0285462671304449 425 372 366 0.00189780880678499 164 2.60699271513508 -3.55485428018627 -1 5.61267261818163 423 303 493 265 346 401 366 577 164 225 529 394 M17311 GO_EARLY_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding an early endosome. 84/194 Gene Ontology CC GO:0031901 0.0839184282471183 0.105675057792668 520 384.363636363636 367 0.00793650793650794 192 1.489957325168 -1.08142086197341 -1 2.02717727701896 517 367 192 230 566 357 492 536 250 231 490 395 M17415 GO_SMALL_SUBUNIT_PROCESSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_SUBUNIT_PROCESSOME.html A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 16/36 Gene Ontology CC GO:0032040 0.190419390781491 0.2283452445471 520 350.181818181818 367 0.0190203259502656 178 0.456256846558562 -0.456256846558562 -1 0.40794308924091 178 457 367 481 389 202 261 230 518 517 252 396 M17281 GO_PROTEIN_DNA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX.html A macromolecular complex containing both protein and DNA molecules. 88/191 Gene Ontology CC GO:0032993 0.0839184282471183 0.105675057792668 370 363 368 0.00793650793650794 187 1.00266968872743 -0.869522568920729 -1 1.36419288467064 187 368 327 485 383 331 371 359 396 420 366 397 M17292 GO_EXON_EXON_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXON_EXON_JUNCTION_COMPLEX.html A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. 15/51 Gene Ontology CC GO:0035145 0.166789202070614 0.202105154710304 345 387.727272727273 368 0.0164512312645327 172 0.131179937088406 -0.163163020181551 -1 0.126983393868345 341 554 368 534 495 225 172 265 574 508 229 398 M17530 GO_AXON_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_CYTOPLASM.html Any cytoplasm that is part of a axon. 20/40 Gene Ontology CC GO:1904115 0.000115329837169689 0.000261118320608555 360 406.272727272727 368 1.04850803190463e-05 250 1.19342481685972 1.29307611190594 1 5.96097689903612 577 359 303 325 250 380 485 501 368 358 563 399 M17103 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX.html A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. 51/124 Gene Ontology CC GO:0090575 0.00136921206534955 0.00246543480925868 450 359.090909090909 369 0.000124551360354179 168 1.44774356661277 1.69872303616151 1 5.26347799615104 449 369 253 462 304 550 410 171 168 363 451 400 M17626 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT.html A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. 77/169 Gene Ontology CC GO:0005793 0.0187771152986967 0.0285462671304449 375 352.272727272727 369 0.00172175640958697 129 1.8391257862408 -1.62409159902531 -1 3.9595089153698 372 389 129 369 340 578 500 314 272 183 429 401 M17828 GO_MHC_CLASS_I_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_COMPLEX.html A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. 15/39 Gene Ontology CC GO:0042612 0.0839184282471183 0.105675057792668 365 380.272727272727 369 0.00793650793650794 214 2.15698207673666 -1.63551345799698 -1 2.93470491886581 361 448 214 270 472 349 405 564 369 312 419 402 M17219 GO_SNARE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_COMPLEX.html A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. 28/55 Gene Ontology CC GO:0031201 0.00576610847541187 0.00952231628225161 375 362.727272727273 372 0.000525570626656107 194 1.35412312821355 -1.35412312821355 -1 3.81536091860348 373 388 364 358 325 372 539 194 387 394 296 403 M17579 GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX.html A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. 13/27 Gene Ontology CC GO:0032806 0.0839184282471183 0.105675057792668 375 352.909090909091 372 0.00793650793650794 196 1.34089031768168 -1.8818988242565 -1 1.82436256967402 439 372 319 329 417 392 454 196 305 374 285 404 M17643 GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX.html Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. 67/172 Gene Ontology CC GO:0031461 2.77844292250084e-05 7.26669687423297e-05 490 358.454545454545 372 2.52588910261055e-06 169 1.50894502393015 -0.900555552899335 -1 8.70541199060749 486 352 278 394 217 527 438 192 169 372 518 405 M17764 GO_BRUSH_BORDER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER_MEMBRANE.html The portion of the plasma membrane surrounding the brush border. 27/96 Gene Ontology CC GO:0031526 3.01887675230925e-05 7.78978019122656e-05 550 378.090909090909 372 2.74447107148747e-06 145 1.74093152960042 1.53382672117031 1 9.97052830109862 546 386 145 322 219 513 525 356 372 255 520 406 M17409 GO_CHLORIDE_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_COMPLEX.html An ion channel complex through which chloride ions pass. 8/50 Gene Ontology CC GO:0034707 0.0685511210369449 0.0975924826585077 405 345.545454545455 373 0.00707624173967679 125 1.68628085399293 -2.13235417240104 -1 2.37551629802115 402 396 499 433 411 373 357 187 125 317 301 407 M17052 GO_AUTOPHAGOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME.html A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. 51/88 Gene Ontology CC GO:0005776 1.85218927823489e-05 5.09793048961793e-05 365 376.272727272727 374 1.6838226109803e-06 205 1.031053088584 -0.873802861969218 -1 6.16961290148347 408 258 363 389 205 374 563 511 307 362 399 408 M17412 GO_CLATHRIN_COAT_OF_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_COATED_PIT.html The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. 12/22 Gene Ontology CC GO:0030132 0.0839184282471183 0.105675057792668 475 424.090909090909 375 0.00793650793650794 263 0.794471725861725 -0.789385336272928 -1 1.08092692515043 474 307 304 263 375 573 561 526 365 368 549 409 M17315 GO_MYELIN_SHEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_SHEATH.html An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. 124/303 Gene Ontology CC GO:0043209 0.00133463393214734 0.00241068253994114 385 360.454545454545 376 0.000121404025320782 161 1.89029907076936 -1.40202427596161 -1 6.89815241574798 382 482 177 345 303 457 360 419 161 376 503 410 M17438 GO_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the Golgi apparatus. 415/943 Gene Ontology CC GO:0000139 7.81885929643276e-06 2.50474537565975e-05 500 376.636363636364 376 7.10807916818883e-07 171 1.38065185009365 -1.2726758555448 -1 8.8555304326447 500 280 260 376 171 496 420 569 302 238 531 411 M17757 GO_NBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NBAF_COMPLEX.html A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 8/16 Gene Ontology CC GO:0071565 0.112725750737973 0.140724587314359 570 392.454545454545 376 0.0118888778053339 159 0.662310073571786 0.662310073571786 1 0.78626355229129 359 298 568 347 376 365 159 480 414 566 385 412 M17463 GO_BLOC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_COMPLEX.html Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. 8/21 Gene Ontology CC GO:0031082 0.0241665056618664 0.0359441416895578 185 334.818181818182 379 0.00244334089016872 157 0.764287356899782 -0.764287356899782 -1 1.53883317258098 295 379 508 384 471 192 184 157 407 525 181 413 M17576 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE.html The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 12/24 Gene Ontology CC GO:0031304 0.546861536651561 0.604370876069985 350 412.727272727273 379 0.0694316742347653 286 0.479038366097967 -0.479038366097967 -1 0.146038633091902 369 475 349 496 412 286 336 379 540 549 349 414 M17795 GO_HISTONE_DEACETYLASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_COMPLEX.html A protein complex that possesses histone deacetylase activity. 32/70 Gene Ontology CC GO:0000118 0.0839184282471183 0.105675057792668 365 399 379 0.00793650793650794 282 1.00708646331317 -0.907981542742338 -1 1.37020217445329 534 442 306 449 381 364 361 561 379 282 330 415 M16993 GO_NUCLEAR_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE.html The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). 223/592 Gene Ontology CC GO:0005635 2.40510479189625e-05 6.34771949642025e-05 540 409.363636363636 381 2.18648280510236e-06 215 1.24028735112842 -1.11105590110225 -1 7.25699276881616 540 481 374 540 215 333 519 354 355 411 381 416 M17297 GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX.html A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. 41/83 Gene Ontology CC GO:0070603 0.0839184282471183 0.105675057792668 565 430.272727272727 381 0.00793650793650794 263 1.27442763679495 -0.995362080861447 -1 1.7339360601418 564 305 263 352 369 518 553 562 330 381 536 417 M17153 GO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAJAL_BODY.html A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. 28/64 Gene Ontology CC GO:0015030 0.597612431062712 0.652967835830335 490 416 383 0.0794262308166932 285 0.833751493024063 -0.833751493024063 -1 0.215138455990707 285 552 383 550 523 334 300 315 486 488 360 418 M17178 GO_PRECATALYTIC_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRECATALYTIC_SPLICEOSOME.html A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. 13/27 Gene Ontology CC GO:0071011 0.617124554115612 0.673015079771366 355 398.454545454545 383 0.0835766678948928 239 0.650651868502036 -0.650651868502036 -1 0.155980465553728 239 538 354 387 484 346 383 352 474 492 334 419 M17358 GO_SPECIFIC_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFIC_GRANULE.html Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. 11/29 Gene Ontology CC GO:0042581 0.0839184282471183 0.105675057792668 465 379.090909090909 383 0.00793650793650794 213 2.482161549779 -2.482161549779 -1 3.37713132006471 420 461 264 313 426 464 364 383 213 352 510 420 M17061 GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 133/294 Gene Ontology CC GO:0061695 0.000281289764790047 0.000576544269676054 415 382.454545454545 384 2.55750669684365e-05 263 1.15073075491465 -0.84766889672803 -1 5.19592598006058 414 397 384 519 271 297 343 534 263 431 354 421 M17567 GO_POLYSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSOME.html A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. 15/60 Gene Ontology CC GO:0005844 0.0839184282471183 0.105675057792668 485 400.454545454545 384 0.00793650793650794 144 1.90549678679359 -0.689550038146136 -1 2.5925439246831 485 458 292 342 556 378 326 493 144 384 547 422 M16976 GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. 82/187 Gene Ontology CC GO:0000784 0.378837111641396 0.433599704017281 100 361.272727272727 385 0.0423639203672024 100 0.870833099286815 -0.878642682584731 -1 0.440545618111229 100 471 385 524 419 282 299 273 467 437 317 423 M17104 GO_INO80_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INO80_TYPE_COMPLEX.html A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. 17/26 Gene Ontology CC GO:0097346 0.573589005973823 0.631494181814989 350 410.818181818182 385 0.0745604926106656 320 0.54209528580132 -0.54209528580132 -1 0.150854591773379 347 494 341 474 453 351 320 385 548 481 325 424 M17189 GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. 7/32 Gene Ontology CC GO:0032281 1.86588977563e-05 5.11129995409546e-05 210 327.454545454545 385 1.86590544276609e-06 166 0.90042672087476 -0.751976009954791 -1 5.3865434514276 385 166 462 209 208 424 287 411 431 224 395 425 M17737 GO_COHESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_COHESIN_COMPLEX.html A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). 8/14 Gene Ontology CC GO:0008278 0.195268675726234 0.233192757375544 260 380.727272727273 385 0.0214904003277263 255 1.02272800839666 1.02272800839666 1 0.901423376806019 255 407 563 438 385 258 260 482 491 321 328 426 M17529 GO_SEMAPHORIN_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_COMPLEX.html A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. 3/11 Gene Ontology CC GO:0002116 0.51109159148494 0.569192562385926 320 402.727272727273 388 0.0690577289289544 247 0.841478148107057 1.18079972020767 1 0.28708133490729 319 317 530 362 443 388 247 368 487 539 430 427 M17546 GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX.html RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 6/22 Gene Ontology CC GO:0005665 0.46139569794759 0.517838278473217 320 405.363636363636 388 0.060001886952572 307 0.246156338188004 -0.241103427951605 -1 0.0980703528745496 363 385 532 396 418 320 319 388 489 542 307 428 M17102 GO_NUCLEOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLAR_PART.html Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. 31/65 Gene Ontology CC GO:0044452 0.0833220187518098 0.105675057792668 480 349.181818181818 390 0.00787780920733057 132 0.766201182657067 -0.766201182657067 -1 1.04246313599131 132 465 390 533 555 170 211 189 480 480 236 429 M17397 GO_CELL_DIVISION_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION_SITE.html The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. 31/80 Gene Ontology CC GO:0032153 0.00172336855631602 0.00304619885489498 495 359.363636363636 391 0.000156792730757426 195 1.73770783572967 -0.883448533773732 -1 6.0951580900183 492 490 203 454 308 405 441 199 195 375 391 430 M17464 GO_BETA_CATENIN_DESTRUCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX.html A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. 7/18 Gene Ontology CC GO:0030877 0.0128591862336045 0.0203633140904751 245 367.545454545455 391 0.00129342093602024 81 0.303777617941405 0.343426598755314 1 0.716133711165633 242 543 509 504 391 191 81 381 465 526 210 431 M17533 GO_MIDBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBODY.html A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. 90/198 Gene Ontology CC GO:0030496 0.0839184282471183 0.105675057792668 455 386.090909090909 392 0.00793650793650794 227 1.58697549883624 -1.29566913838851 -1 2.15917638823389 451 550 227 457 399 247 380 565 312 392 267 432 M17028 GO_NUCLEOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOID.html The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. 39/68 Gene Ontology CC GO:0009295 0.587276492764585 0.645334244901008 335 428.636363636364 393 0.0773012595560455 298 0.659563579545397 -0.659563579545397 -1 0.174887109201059 334 532 393 516 552 298 374 378 526 468 344 433 M17078 GO_COPI_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_VESICLE_COAT.html One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. 9/13 Gene Ontology CC GO:0030126 0.0849859892753149 0.106786743045939 450 399.818181818182 393 0.00884226534220561 247 1.29751163917361 -1.20189349116474 -1 1.75712297032449 427 384 446 372 371 450 358 551 399 247 393 434 M17247 GO_SET1C_COMPASS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SET1C_COMPASS_COMPLEX.html A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. 5/11 Gene Ontology CC GO:0048188 0.271958859494997 0.315837151365114 355 383 393 0.0312413526619183 251 0.434894544427673 -0.434894544427673 -1 0.303442028909918 352 393 475 305 454 251 419 343 459 503 259 435 M17259 GO_PML_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PML_BODY.html A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. 58/135 Gene Ontology CC GO:0016605 0.000151543433762881 0.000331788275435398 555 375.272727272727 395 1.37776248721325e-05 82 2.10900246722615 -1.43201696766365 -1 10.2283296456951 551 354 184 461 257 395 549 438 82 289 568 436 M17614 GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME.html Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. 50/110 Gene Ontology CC GO:0016591 0.00043822429577234 0.00087644859154468 410 370.636363636364 396 3.98465101158666e-05 106 1.36027574854795 1.78599401430322 1 5.79718427639857 406 370 372 495 277 335 409 494 106 417 396 437 M17650 GO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. 102/223 Gene Ontology CC GO:0000781 0.392093825987548 0.447002428837875 135 369.181818181818 396 0.0442401607221514 131 0.825071671017655 -0.845185842259082 -1 0.402189592006968 131 470 396 526 425 284 313 277 476 441 322 438 M17800 GO_SITE_OF_DOUBLE_STRAND_BREAK http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_DOUBLE_STRAND_BREAK.html A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. 22/46 Gene Ontology CC GO:0035861 0.727248268154896 0.785699998118747 375 413.636363636364 396 0.111400349901199 330 0.638119984353623 -0.638119984353623 -1 0.0931716894963352 340 433 330 469 427 371 396 344 495 571 374 439 M17329 GO_ARP2_3_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_PROTEIN_COMPLEX.html A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. 6/11 Gene Ontology CC GO:0005885 0.0463870752418373 0.0673661544969397 540 401.545454545455 398 0.0047384807205797 249 0.929995739577453 -0.929995739577453 -1 1.51880032646421 538 363 487 296 355 432 388 249 401 510 398 440 M17780 GO_PROTEASOME_ACCESSORY_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ACCESSORY_COMPLEX.html A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. 17/28 Gene Ontology CC GO:0022624 0.387794373493059 0.442974600551359 270 404.272727272727 398 0.0436276121301165 268 0.74351706699215 -0.74351706699215 -1 0.366509293890151 268 466 360 473 507 281 398 329 511 568 286 441 M17276 GO_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME.html Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. 35/70 Gene Ontology CC GO:0030684 0.212245270580724 0.251905064467471 150 373 399 0.0214545503816207 147 0.5104799369033 -0.5104799369033 -1 0.426078385741708 147 491 399 545 529 187 207 281 546 506 265 442 M17532 GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 65/154 Gene Ontology CC GO:0044798 0.000758347814024862 0.00142776884855495 500 396.636363636364 399 6.89644859481553e-05 257 1.35122758660961 1.67998039945754 1 5.35943296417735 497 399 271 502 294 440 487 289 257 388 539 443 M17739 GO_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX.html A macromolecular complex containing both protein and RNA molecules. 426/991 Gene Ontology CC GO:1990904 0.0839184282471183 0.105675057792668 200 406.545454545455 399 0.00793650793650794 199 1.11275122650103 -0.752173671325249 -1 1.51396549528458 199 517 426 559 577 253 290 399 377 563 312 444 M16985 GO_PHAGOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. 84/188 Gene Ontology CC GO:0045335 7.97855561787656e-06 2.52427563396113e-05 495 369.545454545455 400 7.25325868471131e-07 173 1.34468100875895 -1.33133274089447 -1 8.61848978945669 493 424 230 327 173 400 564 413 341 294 406 445 M17390 GO_HISTONE_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_COMPLEX.html A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. 47/95 Gene Ontology CC GO:0035097 0.0806522968337151 0.105675057792668 340 369.909090909091 400 0.00761547950584411 148 2.3571340114312 3.10458964995788 1 3.20702376891934 339 520 233 458 477 515 418 188 148 400 373 446 M17806 GO_GOLGI_CISTERNA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA_MEMBRANE.html The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. 38/86 Gene Ontology CC GO:0032580 7.24681422240234e-05 0.000170965657981573 505 391.909090909091 400 6.58822994903663e-06 223 1.15008821446587 -1.00103509527348 -1 6.03939074399203 501 323 223 400 238 537 330 514 422 250 573 447 M16997 GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the nucleus. 9/15 Gene Ontology CC GO:0000176 0.261341896765364 0.305162861273496 395 414.545454545455 401 0.0298378061366977 336 0.689550038146136 -0.689550038146136 -1 0.495477083444948 336 467 432 412 392 347 395 394 519 465 401 448 M17543 GO_NADH_DEHYDROGENASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX.html An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. 31/51 Gene Ontology CC GO:0030964 0.164907586461201 0.200244926417173 185 359.090909090909 401 0.016249518284584 183 0.580180789100938 -0.580180789100938 -1 0.564868443248372 183 455 401 488 421 195 212 313 513 541 228 449 M17067 GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 143/347 Gene Ontology CC GO:0031300 0.0200191887410114 0.0302908143777606 300 390.818181818182 402 0.00183670100171252 253 1.26665542550742 -1.075905248998 -1 2.68153330467288 483 328 297 432 344 402 475 440 299 253 546 450 M17783 GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX.html A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. 9/24 Gene Ontology CC GO:0000159 0.0765897756730953 0.105675057792668 335 387.909090909091 402 0.00793650793650794 166 3.22826261986104 3.22826261986104 1 4.39224709068431 381 402 572 335 444 562 434 415 166 333 223 451 M17116 GO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE.html A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. 682/1632 Gene Ontology CC GO:0005773 1.30233744415245e-06 7.10142493132185e-06 490 343.909090909091 403 1.30233820739035e-07 92 1.45321492290644 -1.33869683964865 -1 10.4298833484238 487 215 453 408 92 322 535 456 261 151 403 452 M17053 GO_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). 57/168 Gene Ontology CC GO:0015934 0.00911585297917029 0.0145954654347934 115 306.272727272727 404 0.00083216779356727 67 0.628765010948361 -0.559583489887826 -1 1.60903438647404 115 439 417 447 404 94 67 274 490 473 149 453 M17495 GO_RESPIRATORY_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN.html The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. 44/93 Gene Ontology CC GO:0070469 0.452793240457087 0.509172165338904 475 380.909090909091 404 0.0533366000453821 237 0.737803887909284 -0.609873551271199 -1 0.301484438339951 237 441 404 471 469 296 275 393 471 436 297 454 M17501 GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX.html Any of the heteromeric enzymes that act in the TCA cycle. 5/13 Gene Ontology CC GO:0045239 0.275743564408709 0.31939835717081 395 441.909090909091 404 0.0317461415770116 387 0.21141057636281 -0.236234181899572 -1 0.146073919715916 391 446 520 391 393 387 443 392 560 534 404 455 M17605 GO_MICROTUBULE_ASSOCIATED_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ASSOCIATED_COMPLEX.html Any multimeric complex connected to a microtubule. 62/174 Gene Ontology CC GO:0005875 0.0839184282471183 0.105675057792668 410 405.818181818182 405 0.00793650793650794 258 1.09015390412355 -1.31946204499274 -1 1.48322046724617 397 353 258 509 521 410 273 405 390 408 540 456 M17007 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE.html A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. 23/33 Gene Ontology CC GO:0000407 0.0839184282471183 0.105675057792668 450 414.818181818182 406 0.00793650793650794 334 1.24625595332509 1.02002732447308 1 1.69560677564953 338 534 334 498 433 406 362 446 388 377 447 457 M17236 GO_NUCLEAR_NUCLEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_NUCLEOSOME.html A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. 29/61 Gene Ontology CC GO:0000788 0.519273053360014 0.577191970850169 410 374.363636363636 406 0.0644183853440069 129 0.800386288607798 -0.800386288607798 -1 0.266299848639173 129 406 256 406 464 369 422 372 504 418 372 458 M17237 GO_PCG_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PCG_PROTEIN_COMPLEX.html A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. 33/52 Gene Ontology CC GO:0031519 0.0839184282471183 0.105675057792668 315 416.818181818182 406 0.00793650793650794 299 1.22022324913565 1.57851177553035 1 1.66018770223677 313 504 299 531 394 445 378 496 381 406 438 459 M17371 GO_INTRACELLULAR_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_VESICLE.html Any vesicle that is part of the intracellular region. 696/1799 Gene Ontology CC GO:0097708 1.41413929878508e-06 7.40372526308368e-06 225 315.909090909091 406 1.41414019869137e-07 53 1.61764371551883 -1.42689550505725 -1 11.5691813099327 413 66 494 221 96 519 406 418 223 53 566 460 M17618 GO_LATERAL_ELEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_ELEMENT.html A proteinaceous core found between sister chromatids during meiotic prophase. 8/115 Gene Ontology CC GO:0000800 0.445242957506442 0.501657757190494 360 432.636363636364 406 0.057220170344642 278 0.946874415814942 0.946874415814942 1 0.39543860455928 356 333 545 404 406 381 278 531 497 553 475 461 M16996 GO_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_COMPLEX.html A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. 47/87 Gene Ontology CC GO:0000502 0.0241907804796505 0.0359441416895578 95 326.818181818182 407 0.00222372235602271 91 0.704062035642578 -0.704062035642578 -1 1.41757416601769 91 432 407 544 564 128 155 178 475 464 157 462 M17069 GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX.html A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. 10/16 Gene Ontology CC GO:0005671 0.759842029421916 0.817856039117072 345 432.636363636364 408 0.121621805684191 343 0.201060177678699 -0.22327733558447 -1 0.0244742967266429 343 524 348 567 432 345 408 360 569 476 387 463 M17206 GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX.html A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. 8/18 Gene Ontology CC GO:0005852 0.000644690484992752 0.00122576019844017 245 314.363636363636 408 6.44877593013866e-05 45 0.219704997392852 -0.250044331791022 -1 0.891716187932992 245 445 466 413 408 78 45 246 542 496 74 464 M17134 GO_NUCLEAR_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INCLUSION_BODY.html An intranuclear focus at which aggregated proteins have been sequestered. 9/14 Gene Ontology CC GO:0042405 0.0612662418281796 0.0883089470740344 455 384.363636363636 409 0.0063023938356467 182 2.00966166660681 2.00966166660681 1 2.95268737330453 321 575 454 409 451 425 465 182 338 328 280 465 M17221 GO_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIGASE_COMPLEX.html A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. 134/305 Gene Ontology CC GO:0000151 0.0839184282471183 0.105675057792668 440 420.636363636364 409 0.00793650793650794 249 1.19649598909406 -0.898676644036068 -1 1.62790532545482 436 500 375 539 402 249 486 567 328 409 336 466 M17339 GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT.html The large subunit of a ribosome located in the cytosol. 34/129 Gene Ontology CC GO:0022625 0.00639389611450167 0.0105289799264444 410 354.363636363636 410 0.000582959523920847 55 0.607311213370888 -0.607311213370888 -1 1.67420487732296 219 483 410 407 487 104 55 515 543 511 164 467 M17353 GO_COPI_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE.html A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. 17/32 Gene Ontology CC GO:0030137 0.0163610799386625 0.0252178778787917 450 417.818181818182 410 0.00149854881909194 326 1.29751163917361 -1.20189349116474 -1 2.8908335645729 450 474 357 388 336 462 332 549 410 326 512 468 M17458 GO_MITOCHONDRIAL_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_PART.html Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. 95/199 Gene Ontology CC GO:0044455 0.232850105696956 0.274108678396823 225 385.727272727273 412 0.0238095238095238 223 0.879357563281688 -0.763103493564098 -1 0.688996954701291 223 528 412 557 532 277 283 243 424 440 324 469 M17457 GO_XY_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XY_BODY.html A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. 11/32 Gene Ontology CC GO:0001741 0.878661814103 0.930158477200611 400 427 413 0.174481053455544 243 0.606119283272796 -0.606119283272796 -1 0.0265667059111025 400 413 243 452 568 396 340 434 539 523 389 470 M17155 GO_TRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX.html A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). 385/832 Gene Ontology CC GO:1990234 0.0839184282471183 0.105675057792668 415 416.545454545455 414 0.00793650793650794 242 1.28782682112243 -0.823673111393572 -1 1.75216646332667 457 516 411 573 414 242 384 499 287 452 347 471 M17461 GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the inner mitochondrial membrane. 63/124 Gene Ontology CC GO:0098800 0.495711769609015 0.553130121301178 295 403.454545454545 414 0.0603398637190108 181 0.574872674835986 -0.574872674835986 -1 0.206087784099684 181 530 414 538 533 291 294 331 494 524 308 472 M17710 GO_MICROTUBULE_ORGANIZING_CENTER_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_PART.html Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. 74/194 Gene Ontology CC GO:0044450 0.00262732776633884 0.00457408267754172 560 428.090909090909 414 0.000239133698361967 301 1.31615701095936 -1.21580795631658 -1 4.29262530627962 556 453 301 386 313 414 532 495 348 403 508 473 M17241 GO_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of a ribosome. 52/104 Gene Ontology CC GO:0015935 0.178657110100366 0.21603307455651 230 366.363636363636 415 0.0177331213759969 172 0.546903050355665 -0.546903050355665 -1 0.507342212906843 228 510 415 479 424 172 213 312 537 502 238 474 M17404 GO_PROTEASOME_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_CORE_COMPLEX.html A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. 11/22 Gene Ontology CC GO:0005839 0.482894657806469 0.540916884132052 360 418.090909090909 415 0.0581934001566224 237 0.184455837502303 -0.272613526465299 -1 0.0686193780679391 360 462 379 431 534 353 237 404 508 516 415 475 M17570 GO_EXOCYST http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYST.html A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. 10/21 Gene Ontology CC GO:0000145 0.191711721462325 0.229418995870029 560 404.454545454545 416 0.0191627870217542 188 1.343402802084 -1.60119912593207 -1 1.19733248011076 558 392 188 286 522 512 416 232 435 344 564 476 M17821 GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX.html A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. 6/13 Gene Ontology CC GO:0036513 0.00433506403224762 0.00732651172701499 175 339.818181818182 416 0.000434354407489539 115 0.8273088280295 -0.8273088280295 -1 2.46230747633176 175 416 575 420 530 133 175 142 483 574 115 477 M17703 GO_TELOMERE_CAP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAP_COMPLEX.html A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. 5/14 Gene Ontology CC GO:0000782 0.331999539254503 0.382972826836295 375 419.636363636364 417 0.0395435526902308 250 0.226585624230221 -0.287140115660132 -1 0.131658563476146 375 417 557 450 573 250 256 375 527 559 277 478 M17847 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. 16/39 Gene Ontology CC GO:0000307 0.0839184282471183 0.105675057792668 505 406.181818181818 417 0.00793650793650794 245 1.62052265163217 -1.45207462392387 -1 2.20481932486551 505 447 245 417 458 412 404 510 321 263 486 479 M17301 GO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. 257/549 Gene Ontology CC GO:0000785 5.88988942748034e-05 0.000143643716838972 420 401.818181818182 418 5.35458828984896e-06 232 1.40708639358097 -1.06690877267203 -1 7.5372792572807 418 438 236 560 232 367 477 540 317 425 410 480 M17688 GO_WASH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_WASH_COMPLEX.html A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. 5/11 Gene Ontology CC GO:0071203 0.142685901219564 0.177360109472921 560 411.909090909091 418 0.0152771931569586 167 0.981185001101766 0.981185001101766 1 1.02737729633721 348 559 554 418 510 263 167 302 493 558 359 481 M17089 GO_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME.html An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. 141/339 Gene Ontology CC GO:0005840 0.053837739964735 0.0777955342490421 90 332.636363636364 419 0.0050183840239627 89 0.617992247473702 -0.595876951495486 -1 0.955406418331526 89 501 419 507 455 134 139 240 500 479 196 482 M17289 GO_NUCLEAR_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_REPLICATION_FORK.html The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 30/42 Gene Ontology CC GO:0043596 0.0839184282471183 0.105675057792668 435 415.090909090909 419 0.00793650793650794 273 1.34535636655016 -0.684848189441816 -1 1.83043890010772 433 358 273 419 434 413 389 554 357 423 513 483 M17285 GO_STEREOCILIUM_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEREOCILIUM_BUNDLE.html A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. 19/77 Gene Ontology CC GO:0032421 0.017175626945811 0.026332924070766 575 373.181818181818 420 0.0015737457282714 150 2.18374187857974 -2.70324798423132 -1 4.80813921887058 575 420 198 337 479 520 541 150 179 279 427 484 M17653 GO_TOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_COMPLEX.html A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. 7/17 Gene Ontology CC GO:0038201 0.214139132665174 0.253113330634909 415 419.636363636364 420 0.0238095238095238 289 0.890197844458448 -0.890197844458448 -1 0.74043589883572 412 289 549 371 470 431 479 474 420 309 412 485 M17047 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE.html The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 12/28 Gene Ontology CC GO:0031306 0.415320710913563 0.469775676923756 355 405.363636363636 421 0.0476190476190476 302 0.974211918395973 0.974211918395973 1 0.445582378059608 355 421 302 476 497 453 373 436 441 365 340 486 M17826 GO_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of acetyltransferase activity. 57/110 Gene Ontology CC GO:1902493 0.0839184282471183 0.105675057792668 360 419 421 0.00793650793650794 140 2.10812698904793 3.25489572195452 1 2.86823460810433 511 567 344 554 474 359 421 358 140 415 466 487 M17429 GO_NUCLEOPLASM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPLASM_PART.html Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. 414/883 Gene Ontology CC GO:0044451 0.0839184282471183 0.105675057792668 315 402.090909090909 422 0.00793650793650794 183 1.34388507961658 -0.969364879313259 -1 1.82843712497393 346 561 422 577 539 183 312 430 311 459 283 488 M17657 GO_REPLISOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLISOME.html A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. 21/29 Gene Ontology CC GO:0030894 0.96855221189793 0.999991629297463 390 435 422 0.26984126984127 358 0.719477462116169 -0.679275287620825 -1 3.58880844854561e-06 389 361 358 415 476 422 400 472 503 556 433 489 M17448 GO_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases. 14/25 Gene Ontology CC GO:0000178 0.0437928181654981 0.0639198204536816 505 430.636363636364 423 0.00406269501678041 318 0.86054401738595 0.946041007005856 1 1.43273475810421 514 391 318 423 353 404 503 497 454 378 502 490 M17469 GO_MISMATCH_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR_COMPLEX.html Any complex formed of proteins that act in mismatch repair. 6/12 Gene Ontology CC GO:0032300 0.333279120931932 0.382972826836295 405 429.727272727273 423 0.0397276907568299 271 0.228180383313977 -0.122699233873395 -1 0.132585205587874 403 423 511 465 445 352 375 271 555 527 400 491 M17483 GO_SPERM_PRINCIPAL_PIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PRINCIPAL_PIECE.html The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. 13/29 Gene Ontology CC GO:0097228 0.148301578556583 0.182768256728582 400 416.363636363636 423 0.0144870185476647 219 0.742523098447982 -0.612331210156272 -1 0.763977456213152 398 537 265 513 490 423 269 219 524 529 413 492 M17540 GO_CHROMOCENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOCENTER.html A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure. 8/17 Gene Ontology CC GO:0010369 0.0765897756730953 0.105675057792668 335 430.909090909091 423 0.00793650793650794 319 3.12144353544104 3.12144353544104 1 4.24691324578583 377 478 531 334 570 494 515 423 334 319 365 493 M17538 GO_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN.html A compact and highly condensed form of chromatin. 42/86 Gene Ontology CC GO:0000792 0.53382759879064 0.591096459963582 425 445 424 0.067029592095203 312 1.05736232263463 -0.803962839846138 -1 0.33656172988322 444 531 312 553 410 394 461 424 522 422 422 494 M17699 GO_NUCLEOLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLUS.html A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. 500/1232 Gene Ontology CC GO:0005730 0.0839184282471183 0.105675057792668 250 392.272727272727 424 0.00793650793650794 216 1.19439237125695 -1.03966719797377 -1 1.62504322576426 249 515 424 576 500 216 321 431 362 460 261 495 M17672 GO_RNAI_EFFECTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNAI_EFFECTOR_COMPLEX.html Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. 4/11 Gene Ontology CC GO:0031332 0.494834976625768 0.553130121301178 330 437.727272727273 427 0.0660076322988421 301 0.164853715026999 -0.164853715026999 -1 0.0590988489327016 416 486 552 427 535 326 315 301 573 557 327 496 M17745 GO_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_PREINITIATION_COMPLEX.html A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. 7/16 Gene Ontology CC GO:0070993 0.238585369840734 0.280289316601513 430 409.454545454545 427 0.0268895827980566 204 0.243756343725731 -0.248603085579209 -1 0.187698228673745 358 427 565 425 546 204 215 429 517 564 254 497 M17114 GO_CYTOSOLIC_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PART.html Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. 123/339 Gene Ontology CC GO:0044445 0.0132016522319207 0.0207352037773102 370 389.636363636364 428 0.0012074130951229 134 0.863636257987466 -0.663501241145982 -1 2.0264975818764 370 548 420 527 496 140 230 544 428 449 134 498 M17721 GO_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE.html The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. 180/399 Gene Ontology CC GO:0005819 0.000213018136451891 0.000456016603219233 355 408.818181818182 428 1.93671604575497e-05 262 1.43910940919077 1.73126351378797 1 6.7023739391881 351 526 267 506 262 542 511 285 340 428 479 499 M17585 GO_GOLGI_TRANSPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TRANSPORT_COMPLEX.html A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). 3/12 Gene Ontology CC GO:0017119 0.272122666747105 0.315837151365114 260 415.727272727273 429 0.0312631516719703 259 0.155263270593671 -0.230753498674912 -1 0.108332896893902 441 429 539 421 491 321 259 259 558 551 304 500 M17467 GO_CATALYTIC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_COMPLEX.html A protein complex which is capable of catalytic activity. 557/1220 Gene Ontology CC GO:1902494 0.0765897756730953 0.105675057792668 430 416.090909090909 430 0.00793650793650794 229 1.26374214905034 -0.96406226918233 -1 1.71939780579361 430 514 510 575 388 229 379 527 289 454 282 501 M16982 GO_RNA_CAP_BINDING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING_COMPLEX.html Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. 10/20 Gene Ontology CC GO:0034518 0.0839184282471183 0.105675057792668 535 364.909090909091 432 0.00793650793650794 56 1.80613566448485 -0.490827793528663 -1 2.45735708969978 532 276 234 196 482 536 495 432 56 338 437 502 M17003 GO_MICROTUBULE_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. 567/1355 Gene Ontology CC GO:0015630 0.000256193350692909 0.000532660995325545 435 435 433 2.56222891250971e-05 272 1.2925980646 1.46621670112063 1 5.89845420599743 390 507 433 561 272 570 356 403 324 435 534 503 M17029 GO_KINESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_COMPLEX.html Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. 23/57 Gene Ontology CC GO:0005871 0.982106417322908 0.999991629297463 435 415.636363636364 434 0.306327783110858 224 0.667390410806611 -0.646086301706928 -1 3.32485115574096e-06 302 411 224 446 494 434 387 444 530 469 431 504 M16994 GO_RETROMER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROMER_COMPLEX.html A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. 15/25 Gene Ontology CC GO:0030904 0.597318307603006 0.652967835830335 430 392 436 0.0793650793650794 213 1.65556184904523 1.84603365522636 1 0.427195717203416 429 436 213 349 478 503 280 483 449 251 441 505 M17018 GO_TRANSCRIPTION_EXPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_EXPORT_COMPLEX.html The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. 14/40 Gene Ontology CC GO:0000346 0.65769588841804 0.714564329897795 355 432.090909090909 438 0.0928610208208487 306 0.599791225856082 -0.599791225856082 -1 0.12203534919601 438 513 353 487 435 306 355 460 564 466 376 506 M17075 GO_ACROSOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_MEMBRANE.html The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. 7/29 Gene Ontology CC GO:0002080 0.33296556889208 0.382972826836295 455 416.909090909091 438 0.0396825396825397 223 1.24828261401855 -1.03913849811777 -1 0.725320305745965 453 415 445 385 420 473 339 486 438 223 509 507 M17608 GO_PHAGOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a phagocytic vesicle. 55/111 Gene Ontology CC GO:0030670 0.0839184282471183 0.105675057792668 530 414.818181818182 438 0.00793650793650794 241 1.33351309327568 -1.11525257939449 -1 1.81432540830511 529 408 282 241 438 448 548 563 353 311 442 508 M17750 GO_MICROTUBULE_ORGANIZING_CENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER.html An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. 354/819 Gene Ontology CC GO:0005815 0.0217496054848749 0.0325680620991132 410 458.909090909091 438 0.00199705909177855 348 1.18980227143839 1.27353718217868 1 2.46662072259364 410 508 400 551 348 568 394 530 359 438 542 509 M17246 GO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME.html A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. 269/639 Gene Ontology CC GO:0005813 0.0168091914953435 0.0258396613944377 555 464.818181818182 442 0.00153991033083485 338 1.15422078203791 -1.10123757823241 -1 2.55456398731389 442 499 395 532 338 553 423 555 366 434 576 510 M17704 GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX.html Any complex formed of proteins that act in nucleotide-excision repair. 11/16 Gene Ontology CC GO:0000109 0.92782301819136 0.978616249114245 445 450.545454545455 445 0.212558924582167 320 0.566150954883573 -0.669270521713079 -1 0.00740863631351562 460 414 320 445 492 418 473 395 535 560 444 511 M17711 GO_NUCLEAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE.html Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. 153/392 Gene Ontology CC GO:0031965 0.0103109136313319 0.0164632819859387 520 445.181818181818 445 0.000941778007723841 331 1.16940425195563 -1.11995213555191 -1 2.90729854672213 520 487 373 542 331 510 445 426 386 416 461 512 M17187 GO_MCM_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MCM_COMPLEX.html A hexameric protein complex required for the initiation and regulation of DNA replication. 6/11 Gene Ontology CC GO:0042555 0.98428420797384 0.999991629297463 440 437.909090909091 446 0.339863680810768 335 0.399984856942277 -0.453018873724335 -1 1.96974188569471e-06 364 335 461 357 489 436 446 437 523 493 476 513 M17188 GO_NUCLEAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_BODY.html Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. 213/505 Gene Ontology CC GO:0016604 0.0839184282471183 0.105675057792668 500 448.818181818182 447 0.00793650793650794 267 1.47540064824674 -0.980362647088622 -1 2.007372034937 499 546 405 570 537 267 391 560 333 447 382 514 M17231 GO_PRONUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRONUCLEUS.html The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. 9/23 Gene Ontology CC GO:0045120 0.214139132665174 0.253113330634909 450 437.090909090909 447 0.0238095238095238 275 3.13259805698275 3.13259805698275 1 2.60558728689544 447 485 474 426 442 531 518 275 418 330 462 515 M17249 GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX.html A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. 4/11 Gene Ontology CC GO:0000164 0.52340095663996 0.580663633278113 395 442.272727272727 447 0.0714285714285714 326 0.681061728500291 0.681061728500291 1 0.224126342867752 394 418 476 326 430 498 507 412 447 504 453 516 M17553 GO_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATION_FORK.html The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 49/81 Gene Ontology CC GO:0005657 0.0839184282471183 0.105675057792668 430 437.363636363636 447 0.00793650793650794 231 1.68261334876419 -0.665165962899561 -1 2.2892974852581 555 409 231 428 466 507 499 447 262 430 577 517 M16990 GO_CONDENSED_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. 55/221 Gene Ontology CC GO:0000794 0.865412014258462 0.92117113816455 300 433.454545454545 448 0.166666666666667 298 0.891515688047004 0.961036966877488 1 0.0443161167043989 298 440 300 459 475 491 444 448 481 433 499 518 M17839 GO_PRIMARY_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_LYSOSOME.html A lysosome before it has fused with a vesicle or vacuole. 12/68 Gene Ontology CC GO:0005766 0.149965838937983 0.184426074268413 560 443 448 0.0146622415620767 284 0.376203568431636 -0.294320432932565 -1 0.385016974862289 557 434 284 306 378 456 536 396 501 577 448 519 M17277 GO_PARANODE_REGION_OF_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARANODE_REGION_OF_AXON.html An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. 6/35 Gene Ontology CC GO:0033270 0.00010403278287986 0.000236736017734485 535 331.818181818182 449 1.04037653469735e-05 11 2.15767008497975 -2.28071318215885 -1 10.9052852877721 533 117 482 11 249 506 556 449 42 207 498 520 M17171 GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the cytoplasm. 11/18 Gene Ontology CC GO:0000177 0.0274094207533025 0.0405182741570558 580 454.454545454545 450 0.00252336251976662 276 0.86054401738595 0.946041007005856 1 1.67023298534917 552 382 276 436 350 482 577 576 450 351 567 521 M17220 GO_DNA_REPLICATION_FACTOR_A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_FACTOR_A_COMPLEX.html A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. 11/14 Gene Ontology CC GO:0005662 0.00268159513175603 0.00465454049896393 315 448.272727272727 451 0.000244079030472644 314 0.723652541020408 -0.647423270933961 -1 2.35254220138997 571 315 331 383 314 534 537 450 451 500 545 522 M17549 GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX.html A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. 12/20 Gene Ontology CC GO:0005942 0.000473177549954568 0.000927997974756193 565 431.181818181818 452 4.30253956336914e-05 268 0.810541648871068 -0.76355460881789 -1 3.42629898661424 565 286 268 381 280 489 392 559 452 544 527 523 M17435 GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX.html A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. 5/10 Gene Ontology CC GO:0031414 0.974353939893331 0.999991629297463 455 463.909090909091 454 0.306730545494578 374 0.158602189718212 -0.171848785314284 -1 7.46506671403798e-07 454 437 503 374 548 403 427 455 536 520 446 524 M17039 GO_CYTOPLASMIC_STRESS_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_STRESS_GRANULE.html A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. 15/44 Gene Ontology CC GO:0010494 0.35943518917414 0.412209403457645 550 450.181818181818 457 0.0396825396825397 287 1.96097570412719 -1.96097570412719 -1 1.05209695527793 550 553 287 511 457 535 501 330 439 382 407 525 M17130 GO_CHROMOSOMAL_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOMAL_REGION.html Any subdivision of a chromosome along its length. 208/530 Gene Ontology CC GO:0098687 0.698152987361708 0.755678701676156 460 456.727272727273 458 0.103174603174603 314 0.964874188858531 -0.904685515932887 -1 0.163638037857808 314 562 406 537 499 426 457 458 462 458 445 526 M17781 GO_CYTOSOLIC_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_RIBOSOME.html A ribosome located in the cytosol. 67/214 Gene Ontology CC GO:0022626 0.0670792996832706 0.0957329264615565 290 388.363636363636 460 0.0062923990562371 127 0.540813243740458 -0.540813243740458 -1 0.768159106546986 288 509 427 460 493 155 127 488 561 569 195 527 M16978 GO_CLATHRIN_SCULPTED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_SCULPTED_VESICLE.html A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. 5/26 Gene Ontology CC GO:0060198 0.814777086179445 0.872113251503184 430 438.545454545455 462 0.155169720084132 211 0.19960113670693 0.272609722460862 1 0.0165349164799984 393 480 428 211 501 486 497 370 570 462 426 528 M17556 GO_SMN_SM_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_SM_PROTEIN_COMPLEX.html A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. 10/21 Gene Ontology CC GO:0034719 0.991888540745733 0.999991629297463 440 465.454545454545 463 0.354467532803464 332 0.241013602759688 -0.240436091118268 -1 1.16413625372269e-06 440 444 332 468 485 459 440 504 538 547 463 529 M17131 GO_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INCLUSION_BODY.html A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. 43/96 Gene Ontology CC GO:0016234 0.039545601369388 0.0580135979479854 480 399.727272727273 464 0.00366135126579919 167 1.69266340922786 -1.05290024730338 -1 2.91749490516218 477 503 222 411 551 472 543 167 226 361 464 530 M17399 GO_NUCLEAR_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_HETEROCHROMATIN.html A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. 25/40 Gene Ontology CC GO:0005720 0.834367499525838 0.891431450510045 490 439.090909090909 465 0.150793650793651 291 1.28638663684732 -1.00861198548302 -1 0.0895019473868228 488 492 291 486 465 433 483 389 477 387 439 531 M17425 GO_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLTRANSFERASE_COMPLEX.html A protein complex that possesses methyltransferase activity. 57/119 Gene Ontology CC GO:0034708 0.0839184282471183 0.105675057792668 520 420 467 0.00793650793650794 203 2.3571340114312 3.10458964995788 1 3.20702376891934 383 519 275 517 536 564 484 258 203 414 467 532 M17542 GO_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX.html Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. 104/251 Gene Ontology CC GO:0005681 0.964712568755578 0.999991629297463 420 474.636363636364 467 0.262154456335252 392 0.746054787106057 -0.746054787106057 -1 3.72349218621061e-06 392 565 418 564 508 420 467 478 534 457 418 533 M17031 GO_HOLO_TFIIH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOLO_TFIIH_COMPLEX.html A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. 7/12 Gene Ontology CC GO:0005675 0.147859119791321 0.182612331708085 560 467.272727272727 470 0.0158730158730159 373 0.799881811106856 0.799881811106856 1 0.82340678875081 559 403 437 373 441 481 557 470 406 470 543 534 M17147 GO_SEX_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_CHROMOSOME.html A chromosome involved in sex determination. 20/46 Gene Ontology CC GO:0000803 0.985023615986936 0.999991629297463 515 456.545454545455 470 0.317460317460317 254 1.08514028574221 -0.606119283272796 -1 5.44184805391719e-06 470 512 254 499 515 444 458 487 514 401 468 535 M17202 GO_ORGANELLE_MEMBRANE_CONTACT_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_CONTACT_SITE.html A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. 4/13 Gene Ontology CC GO:0044232 0.742829351267896 0.801036128792619 475 470.909090909091 472 0.126984126984127 351 0.690409576623159 -0.690409576623159 -1 0.0927266622994742 566 351 464 402 456 488 471 477 472 495 538 536 M17308 GO_NUCLEAR_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. 177/368 Gene Ontology CC GO:0000790 0.000593111494563986 0.00113516041012577 510 425.363636363636 474 5.39337686825397e-05 225 1.52300745203197 -0.980998028891182 -1 6.25222700564703 506 527 225 548 291 407 482 522 271 426 474 537 M17066 GO_TELOMERASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_HOLOENZYME_COMPLEX.html Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. 9/23 Gene Ontology CC GO:0005697 0.972605351317648 0.999991629297463 490 482.909090909091 475 0.302142784050725 397 0.141635101410786 -0.172740580127035 -1 6.60523944722095e-07 489 544 444 470 540 397 437 453 571 475 492 538 M17133 GO_ANAPHASE_PROMOTING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX.html A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. 11/24 Gene Ontology CC GO:0005680 0.998013500142326 0.999991629297463 465 471.909090909091 476 0.431969460993923 274 0.570544305109861 -0.570544305109861 -1 2.83407206121203e-06 503 463 274 480 578 476 447 462 551 484 473 539 M17269 GO_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME.html A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. 313/765 Gene Ontology CC GO:0000228 0.0203798795545882 0.0306759645378958 480 456.454545454545 476 0.00187010504901244 335 1.32821235182409 -0.924628094638874 -1 2.8016907895609 476 525 335 555 345 429 481 578 352 451 494 540 M17380 GO_DNA_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR_COMPLEX.html A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 24/43 Gene Ontology CC GO:1990391 0.990466015903932 0.999991629297463 495 474.909090909091 480 0.344914970331456 381 0.566150954883573 -0.669270521713079 -1 2.81180823934234e-06 491 473 381 505 520 421 480 469 532 512 440 541 M17777 GO_EARLY_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME.html A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. 195/455 Gene Ontology CC GO:0005769 0.0839184282471183 0.105675057792668 385 406.636363636364 481 0.00793650793650794 186 1.48426186884992 1.7390686601682 1 2.01942826316388 384 518 186 494 528 524 509 282 301 266 481 542 M17460 GO_COP9_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_COP9_SIGNALOSOME.html A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. 21/56 Gene Ontology CC GO:0008180 0.0839184282471183 0.105675057792668 510 409.909090909091 484 0.00793650793650794 103 3.08706105740941 3.33251926193233 1 4.2001337984932 507 484 180 299 572 530 494 406 103 369 565 543 M17137 GO_MALE_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GERM_CELL_NUCLEUS.html The nucleus of a male germ cell, a reproductive cell in males. 12/33 Gene Ontology CC GO:0001673 0.996835347426446 0.999991629297463 435 460.181818181818 485 0.407406460303099 261 0.776496849543869 -0.606119283272796 -1 3.87776093797235e-06 431 539 261 367 504 492 424 475 552 485 532 544 M17555 GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX.html A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. 8/22 Gene Ontology CC GO:0005732 0.996346772525741 0.999991629297463 450 493.454545454545 485 0.429484206388805 432 0.161772530014742 -0.188035311459529 -1 7.62572745810045e-07 446 557 535 456 502 454 432 471 544 546 485 545 M17120 GO_NUCLEAR_SPECK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_SPECK.html A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. 122/306 Gene Ontology CC GO:0016607 0.0839184282471183 0.105675057792668 495 478.363636363636 486 0.00793650793650794 351 1.48070491904953 2.05991291718895 1 2.01458881716592 494 549 402 525 486 446 567 463 351 444 535 546 M17226 GO_U2_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U2. 9/24 Gene Ontology CC GO:0005686 0.996961664933977 0.999991629297463 580 505.272727272727 487 0.439902587184414 436 0.13259585816255 -0.132059210955254 -1 6.14716510497664e-07 518 576 472 478 557 471 436 485 577 501 487 547 M17165 GO_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_NUCLEUS.html The nucleus of a germ cell, a reproductive cell in multicellular organisms. 12/37 Gene Ontology CC GO:0043073 0.996835347426446 0.999991629297463 435 461.545454545455 490 0.407406460303099 262 0.776496849543869 -0.606119283272796 -1 3.87776093797235e-06 432 540 262 368 505 493 425 476 553 490 533 548 M16989 GO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME.html A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. 509/1183 Gene Ontology CC GO:0005694 0.0765897756730953 0.105675057792668 470 492.272727272727 491 0.00793650793650794 376 1.32349720537322 -1.01985115455811 -1 1.80069818516573 468 560 431 571 565 441 514 537 376 461 491 549 M17630 GO_INTEGRATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRATOR_COMPLEX.html A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. 9/14 Gene Ontology CC GO:0032039 0.772039985200928 0.829440727595049 550 492.454545454545 491 0.137446845793093 414 0.223824663308862 0.209004635927541 1 0.0253394483854219 535 422 546 414 440 546 414 491 484 554 571 550 M17382 GO_SIN3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_COMPLEX.html A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. 8/19 Gene Ontology CC GO:0016580 0.0458400214619576 0.0667393763350416 515 427.636363636364 495 0.00468140084458346 116 0.407978698483221 -0.407978698483221 -1 0.668589389251915 456 498 495 477 512 325 116 552 545 513 215 551 M17797 GO_U12_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U12_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. 14/35 Gene Ontology CC GO:0005689 0.872066098191596 0.924870100467417 495 490.636363636364 495 0.170499070785486 328 0.934068677022001 -0.934068677022001 -1 0.0441652277708839 495 574 328 541 448 490 513 427 554 570 457 552 M17388 GO_U5_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U5_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U5. 6/20 Gene Ontology CC GO:0005682 0.940634982288152 0.990322440368947 500 489.818181818182 496 0.246031746031746 318 0.50193506106034 -0.50193506106034 -1 0.00295498392893653 544 479 496 318 554 517 533 468 496 514 469 553 M17145 GO_SPINDLE_POLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_POLE.html Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. 77/171 Gene Ontology CC GO:0000922 0.0839184282471183 0.105675057792668 525 463.454545454545 497 0.00793650793650794 321 1.16415396803631 1.20205578475473 1 1.58390204366644 563 502 321 523 372 485 523 521 395 396 497 554 M17325 GO_RIBONUCLEOPROTEIN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_GRANULE.html A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. 98/225 Gene Ontology CC GO:0035770 0.0839184282471183 0.105675057792668 565 446.363636363636 498 0.00793650793650794 178 2.03758632893921 -1.20711016581261 -1 2.77225976043602 498 564 280 552 562 552 463 288 178 412 561 555 M17402 GO_PRC1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRC1_COMPLEX.html A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. 9/12 Gene Ontology CC GO:0035102 0.0129062255711925 0.020381962787293 500 380.636363636364 498 0.00129818008513859 135 0.599313694209253 -0.599313694209253 -1 1.41250652056017 309 541 498 530 498 138 276 198 549 515 135 556 M17218 GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT.html The small subunit of a ribosome located in the cytosol. 33/76 Gene Ontology CC GO:0022627 0.838078482148034 0.893744211589601 570 471.090909090909 499 0.152541193804103 376 0.507564258925243 -0.507564258925243 -1 0.0345181988629279 526 569 408 443 513 376 397 506 567 499 378 557 M17207 GO_CCR4_NOT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR4_NOT_COMPLEX.html The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins. 9/18 Gene Ontology CC GO:0030014 0.926254799246454 0.978616249114245 560 503.272727272727 500 0.229498699255301 402 0.143517576641213 -0.0853166788395206 -1 0.00187802446327937 512 556 467 500 481 576 433 402 559 497 553 558 M17022 GO_U1_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U1_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U1. 6/22 Gene Ontology CC GO:0005685 0.961698357059532 0.999991629297463 580 501.272727272727 501 0.278358101587977 424 0.090544502054076 -0.122542300814845 -1 4.01616290038073e-07 524 578 436 501 549 438 574 445 578 467 424 559 M17493 GO_HEMOGLOBIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_COMPLEX.html An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. 3/15 Gene Ontology CC GO:0005833 0.966975119668002 0.999991629297463 520 469.909090909091 503 0.288976220943205 381 0.390912295356857 0.353594816797119 1 1.92376560685607e-06 411 394 519 390 503 455 381 518 563 531 504 560 M17001 GO_CENTRIOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE.html A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. 54/137 Gene Ontology CC GO:0005814 0.953813513291638 0.999991629297463 515 477.636363636364 504 0.243877317936399 352 0.774202289394197 -0.582364699466936 -1 3.86613298303811e-06 513 489 377 442 518 504 352 543 506 432 578 561 M17706 GO_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE.html Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. 35/99 Gene Ontology CC GO:0005643 0.415320710913563 0.469775676923756 505 483.272727272727 504 0.0476190476190476 350 0.929081308862641 -1.14869999806426 -1 0.424940660870378 504 533 350 562 544 525 560 390 442 429 477 562 M17317 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX.html A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. 14/31 Gene Ontology CC GO:0097526 0.985023615986936 0.999991629297463 480 483.818181818182 505 0.317460317460317 387 0.50193506106034 -0.50193506106034 -1 2.48638660263124e-06 480 459 387 399 525 477 545 520 516 509 505 563 M17478 GO_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. 10/24 Gene Ontology CC GO:0071010 0.798958247137311 0.856767842013666 580 492.545454545455 515 0.135704230058577 336 0.110396837386708 -0.127614459403108 -1 0.0103316811573784 536 577 336 515 511 474 530 355 576 528 480 564 M17639 GO_CONDENSED_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. 135/358 Gene Ontology CC GO:0000793 0.63389956273523 0.690007433636465 550 488.909090909091 517 0.0873015873015873 359 1.17341514885754 1.35153061218584 1 0.263589194208703 376 547 359 536 524 549 517 512 457 446 555 565 M17484 GO_CATALYTIC_STEP_2_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_STEP_2_SPLICEOSOME.html A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. 49/158 Gene Ontology CC GO:0071013 0.866984600625459 0.92117113816455 570 460.272727272727 518 0.167556588723947 303 0.529817170457542 -0.529817170457542 -1 0.0263365178798998 303 568 403 518 559 355 354 519 568 530 386 566 M17516 GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE.html The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. 6/14 Gene Ontology CC GO:0000940 0.996772412416914 0.999991629297463 525 475.454545454545 519 0.436507936507937 312 0.350005289796479 0.319714218414296 1 1.71646451814037e-06 396 347 524 312 519 495 510 523 541 537 526 567 M17248 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY.html A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. 42/84 Gene Ontology CC GO:0000932 0.597318307603006 0.652967835830335 575 496.909090909091 521 0.0793650793650794 397 0.862045090072143 -0.806047812116334 -1 0.222439243399764 547 521 397 572 541 437 575 568 453 421 434 568 M17497 GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX.html A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. 11/24 Gene Ontology CC GO:0046540 0.978161938897681 0.999991629297463 540 499.090909090909 525 0.293650793650794 378 0.50193506106034 -0.50193506106034 -1 2.48638660263124e-06 537 449 378 398 553 509 559 538 512 532 525 569 M17526 GO_U2_TYPE_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. 7/18 Gene Ontology CC GO:0071004 0.960269183155431 0.999991629297463 545 520.272727272727 528 0.27570956588752 416 0.12553102797332 -0.140220374532468 -1 5.78914647961984e-07 554 545 528 512 543 505 491 416 575 538 516 570 M17499 GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 71/125 Gene Ontology CC GO:0000779 0.985023615986936 0.999991629297463 550 512.727272727273 530 0.317460317460317 370 1.04910700666946 -1.0831845369543 -1 5.25924515058925e-06 530 551 370 546 545 529 547 547 515 439 521 571 M17548 GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 8/20 Gene Ontology CC GO:0000780 0.989353804947997 0.999991629297463 535 520.545454545455 533 0.365079365079365 428 0.946874415814942 0.946874415814942 1 4.74116940546807e-06 573 428 533 464 561 533 542 467 525 543 557 572 M17823 GO_DENSE_CORE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENSE_CORE_GRANULE.html Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. 3/17 Gene Ontology CC GO:0031045 0.6882847968182 0.746395145517672 535 485.545454545455 534 0.110029116389287 297 0.372387147699584 0.431464591506035 1 0.0659417610881003 528 311 576 297 550 543 534 338 531 575 558 573 M17846 GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX.html A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. 30/70 Gene Ontology CC GO:0030532 0.998261539973419 0.999991629297463 520 519 535 0.438815221656824 398 0.615556142176103 -0.615556142176103 -1 3.0621748690588e-06 516 571 398 535 558 480 555 465 565 578 488 574 M17768 GO_MAST_CELL_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_GRANULE.html Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. 9/48 Gene Ontology CC GO:0042629 0.951614671425906 0.999991629297463 560 518 541 0.261294437226207 390 0.636933935209298 -0.636933935209298 -1 3.17050936358882e-06 560 555 570 484 467 501 390 541 556 567 507 575 M17356 GO_PERICENTRIC_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIC_HETEROCHROMATIN.html Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. 10/18 Gene Ontology CC GO:0005721 0.978161938897681 0.999991629297463 545 495 542 0.293650793650794 211 1.56416128821162 1.56416128821162 1 7.86934363735776e-06 539 542 211 483 575 544 558 571 510 342 570 576 M17062 GO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CENTROMERIC_REGION.html The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 112/318 Gene Ontology CC GO:0000775 0.991130964772011 0.999991629297463 560 530.181818181818 559 0.349206349206349 389 0.997392999446279 0.945918076941465 1 4.99717830281193e-06 515 563 389 558 571 560 576 575 521 445 559 577 M17472 GO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE.html A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 82/151 Gene Ontology CC GO:0000776 0.995560623481128 0.999991629297463 570 527.909090909091 562 0.388888888888889 376 0.886066851063371 -1.0831845369543 -1 4.43301987942795e-06 521 566 376 528 569 574 568 573 528 442 562 578 M17804 GO_METHYLOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLOSOME.html A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. 6/17 Gene Ontology CC GO:0034709 0.99999927994221 0.99999927994221 575 550.181818181818 572 0.756926992041604 455 0.131282268952106 -0.104280331193971 -1 0 574 558 574 455 574 526 529 574 572 572 544