Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M11765 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 9/20 Gene Ontology BP GO:0034383 1.62136184866839e-07 7.67309571740606e-06 5 694.454545454545 38 1.62136196696504e-08 1 1.8033407415599 1.8033407415599 1 35.013309158879 38 1343 3801 496 20 5 1 1 1257 675 2 2 M10512 GO_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 74/204 Gene Ontology BP GO:0051216 1.93569883449018e-10 2.1398689734614e-08 50 69.8181818181818 46 1.75972621332772e-11 5 1.63344726767108 1.65367129837907 1 47.5538616616001 48 34 42 9 127 49 174 14 220 5 46 3 M15963 GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. 5/24 Gene Ontology BP GO:0036152 4.17231477124963e-05 0.000725545224079102 20 605.727272727273 51 4.1723931102672e-06 12 1.02192717514728 -1.02192717514728 -1 12.1776899353683 168 448 4488 17 17 12 12 190 51 1210 50 4 M12574 GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. 24/49 Gene Ontology BP GO:0036296 2.81526657808292e-07 1.21030395574435e-05 5 76.0909090909091 52 2.55933358031205e-08 1 1.58970850027717 1.58970850027717 1 29.67114173792 2 79 104 52 165 1 10 135 212 37 40 5 M11323 GO_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATRIX_ADHESION.html The binding of a cell to the extracellular matrix via adhesion molecules. 71/186 Gene Ontology BP GO:0007160 1.45987870548839e-08 9.54678426701775e-07 10 186.454545454545 53 1.3271624683417e-09 7 1.59174591454802 1.58124324763408 1 36.3737246219728 7 224 71 178 1196 7 43 8 235 29 53 6 M15782 GO_RESPONSE_TO_HYPEROXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYPEROXIA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. 24/49 Gene Ontology BP GO:0055093 2.81526657808292e-07 1.21030395574435e-05 5 76.5454545454545 53 2.55933358031205e-08 2 1.58970850027717 1.58970850027717 1 29.67114173792 3 80 105 53 166 2 11 130 213 38 41 7 M11781 GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 6/28 Gene Ontology BP GO:0030656 2.16664133371096e-05 0.000455190756218098 65 921.181818181818 62 2.16666245850684e-06 10 0.896585420808603 0.896585420808603 1 11.3731354552026 62 156 3804 996 11 10 44 16 1666 3342 26 8 M13197 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 37/84 Gene Ontology BP GO:2001239 5.39228061571564e-05 0.000887814145346373 15 103.363636363636 65 4.90219344274988e-06 11 1.63842707069121 1.63842707069121 1 18.9789876952561 17 65 253 60 132 55 113 12 301 118 11 9 M16015 GO_AMINOGLYCAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 30/79 Gene Ontology BP GO:0006026 1.18937577203367e-05 0.000276113585477617 5 387.545454545455 65 1.08125654740844e-06 3 1.71707427414222 1.81588458879889 1 23.1960261381343 491 789 326 4 21 1290 1167 3 65 64 43 10 M12592 GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 13/30 Gene Ontology BP GO:0034381 5.15321738737593e-05 0.000862138915575992 20 601.181818181818 67 4.68485281711993e-06 7 1.8033407415599 1.8033407415599 1 20.9765327075332 28 1601 949 1085 67 20 7 19 1923 875 39 11 M12376 GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. 12/52 Gene Ontology BP GO:0061098 0.000248241511629907 0.00282496406494524 45 281.909090909091 74 2.25699569905159e-05 34 1.66030657365034 1.66030657365034 1 16.0643497645359 74 1337 1046 77 44 159 34 45 64 167 54 12 M16001 GO_POSITIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 65/178 Gene Ontology BP GO:0050921 2.88675451184159e-07 1.22965148609913e-05 35 137.454545454545 74 2.62432262784579e-08 34 1.41800927790176 1.46559415295756 1 26.4293860123894 34 37 106 124 163 35 61 74 427 377 74 13 M11939 GO_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHESION.html The attachment of a cell to the underlying substrate via adhesion molecules. 108/262 Gene Ontology BP GO:0031589 4.2507235817157e-09 3.49341679817767e-07 10 296.363636363636 82 3.86429417266249e-10 8 1.52949958664504 1.51773219096565 1 37.486124137811 8 764 56 249 1550 46 82 22 352 26 105 14 M12926 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 26/63 Gene Ontology BP GO:2001240 3.19130943408798e-05 0.000595070269175521 15 136.818181818182 83 2.90123248000865e-06 11 1.61854427990428 1.61854427990428 1 19.8161678699653 11 83 299 90 282 28 15 46 398 230 23 15 M10890 GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. 30/70 Gene Ontology BP GO:0045600 4.29655848883407e-05 0.000741595578574595 10 329.272727272727 84 3.90603854736818e-06 6 1.54222305315961 1.54222305315961 1 18.322113483882 31 1277 947 371 84 6 26 10 331 523 16 16 M16493 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. 26/63 Gene Ontology BP GO:1901099 3.19130943408798e-05 0.000595070269175521 15 137.545454545455 84 2.90123248000865e-06 12 1.61854427990428 1.61854427990428 1 19.8161678699653 12 84 300 91 283 29 16 43 399 232 24 17 M15636 GO_CELLULAR_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 29/58 Gene Ontology BP GO:0071295 1.05840325588466e-07 5.40018276601373e-06 5 255.545454545455 91 9.62184824366949e-09 4 1.64016130364278 1.64016130364278 1 32.7948677629795 4 395 91 480 1032 4 53 26 411 279 36 18 M12140 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. 74/160 Gene Ontology BP GO:2001237 2.02734624345584e-06 6.1123172781594e-05 75 163.454545454545 100 1.84304373790948e-07 8 1.54050488538021 1.59965720140664 1 24.6401656294628 73 368 146 68 129 36 100 18 655 197 8 19 M14469 GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 49/134 Gene Ontology BP GO:0051897 2.05702519216479e-05 0.000438108622349593 20 226 103 1.87004038712515e-06 4 1.67174183631094 1.67174183631094 1 21.3113625239412 19 55 343 48 369 8 216 103 378 943 4 20 M15266 GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 13/33 Gene Ontology BP GO:0060317 1.87315909958125e-05 0.00040078699075372 100 168.818181818182 105 1.70288640774674e-06 2 1.26949422192535 1.38908259956658 1 16.3698443569487 98 119 688 31 105 19 2 236 145 408 6 21 M15014 GO_CONNECTIVE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNECTIVE_TISSUE_DEVELOPMENT.html The progression of a connective tissue over time, from its formation to the mature structure. 103/273 Gene Ontology BP GO:0061448 2.24057263944478e-12 7.43069911781579e-10 10 112.272727272727 106 2.03688421767915e-13 6 1.57101299734537 1.62103979057959 1 54.4388327151421 54 24 14 7 121 106 215 290 273 6 125 22 M14070 GO_REGULATION_OF_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GASTRULATION.html Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. 31/69 Gene Ontology BP GO:0010470 5.93512995845514e-06 0.00015027153882542 20 278.272727272727 113 5.39558724566197e-07 16 1.54226430909572 1.56132842311696 1 22.3812500990808 16 1102 171 280 707 24 30 113 453 69 96 23 M10665 GO_KERATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 17/38 Gene Ontology BP GO:0042339 0.00033440377394494 0.00361078307541013 115 456 114 3.0404964973781e-05 2 1.70760480381546 1.7779009888362 1 15.83110180193 772 101 314 2 52 1155 1590 114 97 111 708 24 M16415 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 23/54 Gene Ontology BP GO:0044246 1.04708068407965e-05 0.000246781503359482 105 183.272727272727 119 9.51896061499119e-07 10 1.61892733549686 1.65722051183935 1 22.1698873404142 119 269 181 10 75 246 104 498 105 35 374 25 M13804 GO_EPIBOLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIBOLY.html The expansion of one cell sheet over other cells or yolk. 23/53 Gene Ontology BP GO:0090504 5.94318189298328e-05 0.000951523914797288 25 367.636363636364 121 5.40303859174899e-06 18 1.37368460182107 1.37368460182107 1 15.7553625168502 22 91 236 353 1021 18 121 87 1334 712 49 26 M15098 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. 5/16 Gene Ontology BP GO:0003198 1.70623759776731e-05 0.000372847937013983 65 656 121 1.70625069851921e-06 3 1.30239349751632 1.30239349751632 1 16.949214775052 61 159 4352 901 51 17 3 299 121 1204 48 27 M11635 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 22/31 Gene Ontology BP GO:1902230 2.71229639440795e-05 0.000542810006863625 200 372 122 2.46575439441511e-06 7 1.85580337477035 1.85580337477035 1 23.0021915767649 196 535 1452 63 257 82 67 48 122 1263 7 28 M10565 GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS.html The process in which the left cardiac ventricle is generated and organized. 4/18 Gene Ontology BP GO:0003214 0.000121013310814619 0.0016722166729532 30 465.727272727273 127 1.21019901219352e-05 3 2.03139865611857 2.03139865611857 1 21.4107814029881 158 450 3605 30 30 102 79 172 3 367 127 29 M10947 GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 137/324 Gene Ontology BP GO:0031668 1.2033964433735e-07 6.00792439417546e-06 80 380 127 1.09399682654464e-08 25 1.46737853664702 1.55918543277327 1 29.0821162542697 79 1627 93 360 639 27 154 49 1000 127 25 30 M15520 GO_RESPONSE_TO_ACIDIC_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACIDIC_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. 7/28 Gene Ontology BP GO:0010447 0.000692114923118133 0.00636627283921067 75 828.636363636364 136 6.92330578034251e-05 42 1.5361147374397 1.5361147374397 1 12.8051867406094 52 1989 4417 326 1386 63 72 136 73 559 42 31 M10231 GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 3/16 Gene Ontology BP GO:0072216 0.000961768522611959 0.00791753767816902 135 609.272727272727 138 9.62185025745742e-05 14 2.46711003640163 2.46711003640163 1 19.6791582008547 133 166 3557 44 1413 70 46 138 14 980 141 32 M15224 GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. 19/42 Gene Ontology BP GO:0061298 3.92782635336394e-06 0.00010727586916864 15 163.909090909091 141 3.57075760547897e-07 13 1.85042576291625 1.85042576291625 1 27.8813937879486 13 98 160 211 669 47 29 204 167 141 64 33 M16151 GO_AORTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_MORPHOGENESIS.html The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. 25/54 Gene Ontology BP GO:0035909 9.82061380023529e-06 0.000233178277424607 150 268.727272727273 148 8.92787058081644e-07 66 1.4890089812476 1.67440687069291 1 20.5299401420235 148 82 179 147 66 619 92 727 274 98 524 34 M12651 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate, or extent of leukocyte migration. 55/148 Gene Ontology BP GO:0002687 1.15439063220962e-08 7.94770143732497e-07 70 402 151 1.04944603478816e-09 67 1.27483517809491 1.31556228890853 1 29.517115032757 70 237 67 466 1592 94 70 67 905 703 151 35 M16142 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. 38/115 Gene Ontology BP GO:0002690 2.95175082588775e-06 8.45986363246717e-05 85 257.181818181818 152 2.68341344206709e-07 40 1.18433844718327 1.21677062131389 1 18.3087511962137 84 252 152 260 524 93 40 57 573 704 90 36 M16663 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY.html Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. 6/14 Gene Ontology BP GO:2000095 0.000243257567323714 0.00280148531020494 155 628.636363636364 152 2.43284199836721e-05 8 1.89800544814465 1.89800544814465 1 18.390326209691 152 906 4600 313 47 62 233 55 8 507 32 37 M12549 GO_PROTEIN_HETEROTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTRIMERIZATION.html The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. 16/31 Gene Ontology BP GO:0070208 0.000488844053132098 0.00479852629744679 510 386.272727272727 158 4.44502462712511e-05 37 1.46778240338295 1.46778240338295 1 12.9196114533571 37 105 509 549 158 90 122 353 1663 510 153 38 M11062 GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. 15/37 Gene Ontology BP GO:0035025 2.80326377693325e-07 1.21030395574435e-05 5 254 160 2.54842194011656e-08 1 1.42202609960647 1.42202609960647 1 26.5414306767934 1 277 281 359 295 11 8 160 1268 82 52 39 M10293 GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of adipocyte differentiation. 70/139 Gene Ontology BP GO:0045598 0.000351650922801927 0.00374475971231501 125 250.818181818182 162 3.19733767030922e-05 47 1.40917163944315 1.40917163944315 1 12.9797112456763 47 369 333 162 291 103 125 56 724 428 121 40 M13080 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. 4/18 Gene Ontology BP GO:2000258 0.000400009938932793 0.0040996546258785 225 935.272727272727 163 4.00081960757505e-05 50 0.847808867288674 0.847808867288674 1 7.68251795747534 225 163 4008 581 60 95 50 149 1239 3645 73 41 M14849 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. 161/358 Gene Ontology BP GO:2000116 2.90481427393009e-05 0.000564283240835162 15 263.272727272727 164 2.64077511721721e-06 7 1.4249950967281 1.52577848687838 1 17.5712983518525 159 13 440 83 164 289 392 7 909 427 13 42 M11648 GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 7/13 Gene Ontology BP GO:0032352 0.00133344848984225 0.00962861794453742 130 673.545454545455 168 0.000133424930442058 43 1.38916827744188 -1.38916827744188 -1 10.6327729616681 130 746 3781 556 146 43 93 168 289 1401 56 43 M14078 GO_CELLULAR_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 37/74 Gene Ontology BP GO:0031670 6.28052317469292e-06 0.000155938337433686 15 397.545454545455 174 5.70958282208819e-07 15 1.64016130364278 1.64016130364278 1 23.7018389223268 15 1018 174 746 1239 31 132 24 533 400 61 44 M11799 GO_LIPID_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. 8/42 Gene Ontology BP GO:0044241 0.000400870816314632 0.0040996546258785 80 774 178 4.00943148514475e-05 24 1.90919498657043 1.90919498657043 1 17.3003908484043 78 143 3806 126 2064 211 24 178 89 1507 288 45 M10271 GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT.html The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. 9/31 Gene Ontology BP GO:0060973 0.000977817751477878 0.00800706846580562 525 903.818181818182 180 9.78248275518483e-05 12 1.99485456575924 1.99485456575924 1 15.875185828803 521 131 3561 101 4319 149 180 94 12 673 201 46 M13687 GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 265/679 Gene Ontology BP GO:0009991 2.55804684055041e-12 7.91800765378369e-10 200 235.363636363636 180 2.32549712777581e-13 15 1.42950272311793 1.57235100831942 1 49.3855233290738 197 180 15 23 444 141 323 210 862 136 58 47 M15980 GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. 32/73 Gene Ontology BP GO:0051057 0.000170115432888425 0.00217279759769568 25 300.272727272727 180 1.54662353201759e-05 25 1.38765075253466 1.42202609960647 1 14.0266974646649 25 69 276 545 358 114 48 322 1290 76 180 48 M15499 GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS.html The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. 14/31 Gene Ontology BP GO:0035313 1.18135618829357e-05 0.00027562998905764 45 399.818181818182 182 1.07396593817157e-06 43 1.46778240338295 1.46778240338295 1 19.832573720934 43 286 182 637 1121 44 63 95 1335 447 145 49 M15950 GO_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 125/310 Gene Ontology BP GO:0007584 3.01939596453251e-10 3.04762075289661e-08 305 261.181818181818 183 2.744905422679e-11 5 1.46824115045135 1.62289692064222 1 41.8883884605596 183 17 46 5 302 911 303 44 472 145 445 50 M11371 GO_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). 238/666 Gene Ontology BP GO:0001501 2.16542107218412e-08 1.32290132080932e-06 140 298.727272727273 184 1.9685646304527e-09 3 1.57026419123321 1.59137579870301 1 35.0384150396011 138 184 76 21 529 765 572 154 463 3 381 51 M13484 GO_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 212/583 Gene Ontology BP GO:0052547 1.34902399140836e-05 0.000307035215299461 175 223 185 1.22639296690575e-06 4 1.40595378706285 1.47132925576635 1 18.747059648476 173 4 185 41 307 286 347 59 806 207 38 52 M16870 GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. 111/365 Gene Ontology BP GO:0010466 8.79685835950692e-06 0.000212728194599951 155 222 185 7.9971759405229e-07 22 1.46406992697419 1.5120103329619 1 20.4076226025586 154 22 177 185 203 264 494 65 583 226 69 53 M14462 GO_CELLULAR_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 6/28 Gene Ontology BP GO:0071467 0.000133462266264965 0.00180660437979076 125 1232.36363636364 191 1.3347028242198e-05 17 1.5361147374397 1.5361147374397 1 15.9947838533396 123 2764 4239 1485 3959 67 74 133 191 504 17 54 M10729 GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 203/467 Gene Ontology BP GO:0071496 5.36434308431948e-07 1.99253159523963e-05 135 527.181818181818 194 4.87667672029815e-08 51 1.48116415274724 1.54870988085173 1 26.4279354892 135 1997 122 631 1214 194 305 92 991 51 67 55 M14974 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. 5/20 Gene Ontology BP GO:0032691 6.22621244374365e-05 0.000976631904604789 30 709.818181818182 196 6.2263868963691e-06 15 1.41813868093395 1.41813868093395 1 16.204336513457 207 447 4326 196 29 89 110 15 1918 442 29 56 M10557 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. 7/24 Gene Ontology BP GO:0032692 5.96941784228376e-06 0.00015027153882542 5 570.727272727273 198 5.96943387762161e-07 5 1.42883632695421 1.42883632695421 1 20.7351898086421 198 304 3602 186 5 178 309 5 1247 213 31 57 M15495 GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. 19/33 Gene Ontology BP GO:0033627 2.3922382440044e-05 0.000485028915585696 35 470.545454545455 199 2.17478568831366e-06 26 1.55588838160164 1.55588838160164 1 19.5735060101919 26 1542 199 1145 380 33 31 50 1353 302 115 58 M13546 GO_KERATAN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 7/15 Gene Ontology BP GO:0042340 8.9043321744279e-05 0.00130831690778066 200 562 200 8.9046889866418e-06 8 1.69362804863984 1.69362804863984 1 18.5358774479164 200 438 4095 8 25 327 698 68 20 214 89 59 M10764 GO_RESPONSE_TO_CORTICOSTEROID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTEROID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 107/288 Gene Ontology BP GO:0031960 1.7076200370272e-10 1.93377556876032e-08 540 333.545454545455 202 1.55238185196341e-11 21 1.4268254266607 1.49911726260662 1 41.7767684996752 202 21 41 103 540 1152 396 141 487 46 540 60 M13195 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. 102/225 Gene Ontology BP GO:2001236 2.16388698338107e-05 0.000455190756218098 275 265.818181818182 202 1.96718933394706e-06 9 1.5010085115715 1.56121152966548 1 19.0402082449943 273 358 193 202 110 332 500 148 614 185 9 61 M13402 GO_AMINOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 83/196 Gene Ontology BP GO:0006022 3.3381581916304e-06 9.39337483863028e-05 30 434.909090909091 202 3.0346938697978e-07 1 1.67674813271439 1.77144657235044 1 25.6316123113394 405 30 155 1 274 1732 1132 54 202 27 772 62 M15797 GO_ADENOHYPOPHYSIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOHYPOPHYSIS_DEVELOPMENT.html The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. 3/17 Gene Ontology BP GO:0021984 5.89703116585298e-05 0.000947401927441362 435 675.272727272727 202 5.89718765909227e-06 12 1.38916827744188 -1.38916827744188 -1 15.9428933055017 434 677 4459 370 108 130 17 202 34 985 12 63 M15024 GO_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOMINERAL_TISSUE_DEVELOPMENT.html Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. 39/111 Gene Ontology BP GO:0031214 6.92694361782954e-07 2.47398455519866e-05 20 331.545454545455 208 6.29722345350491e-08 20 1.67547271302062 1.67547271302062 1 29.2971502211063 20 784 127 398 1179 151 349 72 299 60 208 64 M12492 GO_ARTERY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_MORPHOGENESIS.html The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. 41/97 Gene Ontology BP GO:0048844 2.97472294288842e-07 1.2442917679127e-05 110 193.545454545455 209 2.70429395010427e-08 50 1.46800140765598 1.62091172044007 1 27.3325153572019 50 62 108 268 209 215 108 395 333 155 226 65 M16194 GO_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TISSUE_REMODELING.html Any process that modulates the frequency, rate, or extent of tissue remodeling. 32/85 Gene Ontology BP GO:0034103 0.00109945016496701 0.00830040181453953 210 663.090909090909 209 1e-04 29 1.91805723456887 1.91805723456887 1 15.1502635559166 209 523 474 29 4518 197 203 227 174 578 162 66 M10800 GO_RESPONSE_TO_DIETARY_EXCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DIETARY_EXCESS.html The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. 9/30 Gene Ontology BP GO:0002021 0.000191383548184917 0.00238228904617311 210 918.272727272727 210 1.91400032631157e-05 39 1.81164846487259 1.81164846487259 1 18.0376672194369 210 1450 3639 820 1983 150 58 39 75 1586 91 67 M11483 GO_CHONDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. 19/43 Gene Ontology BP GO:0002063 0.000136060636030377 0.00183642306130535 220 210 218 1.23699137754774e-05 80 1.60257945807845 1.64514507030898 1 16.6435982145958 218 104 269 289 126 390 224 158 312 140 80 68 M11847 GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 52/124 Gene Ontology BP GO:0006023 1.48258867366385e-05 0.000332543923276389 50 623.818181818182 219 1.34781696816512e-06 3 1.58019409777661 1.67427400564541 1 20.8624878543983 348 50 202 3 885 1987 1710 47 219 16 1395 69 M14269 GO_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 17/53 Gene Ontology BP GO:0033280 5.18063229475989e-05 0.000862138915575992 85 593.909090909091 219 4.70977663092148e-06 81 1.98206581287059 1.98206581287059 1 23.0554699918945 81 647 230 112 3927 81 170 219 407 533 126 70 M13521 GO_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_REMODELING.html Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. 22/59 Gene Ontology BP GO:0046850 0.00109945016496701 0.00830040181453953 225 744.545454545455 225 1e-04 46 1.97167988307032 1.97167988307032 1 15.5738157016665 233 1328 608 46 4277 212 144 222 197 698 225 71 M10296 GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that modulates the frequency, rate or extent of protein activation cascade. 12/46 Gene Ontology BP GO:2000257 0.000873422168778815 0.00738670151118404 55 314.181818181818 226 7.94335562760196e-05 55 1.1099059725563 1.1099059725563 1 8.98025836835224 55 559 754 392 85 74 65 226 259 815 172 72 M13139 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET.html The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. 42/92 Gene Ontology BP GO:0002011 0.000139133884228295 0.00185577702597249 65 429.181818181818 229 1.26493349278569e-05 30 1.40812350625992 1.40812350625992 1 14.599738704327 30 63 270 295 1765 64 229 100 1360 482 63 73 M14836 GO_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 65/167 Gene Ontology BP GO:0033273 2.26286458400957e-10 2.44336750315266e-08 60 243 229 2.05714962203848e-11 22 1.58297450639556 1.58297450639556 1 45.7383581351136 56 229 43 22 828 250 191 62 499 234 259 74 M16450 GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. 12/19 Gene Ontology BP GO:1900119 0.000610186763801872 0.00578183090680019 235 462.818181818182 231 5.54869154086857e-05 33 1.42256309632098 1.42256309632098 1 12.0844297876047 232 2268 878 165 139 202 231 153 404 386 33 75 M14467 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 27/39 Gene Ontology BP GO:1902229 2.0882878873481e-05 0.000442736103240056 270 434.090909090909 232 1.89846155463156e-06 5 1.85580337477035 1.85580337477035 1 23.6256345404682 270 270 1713 57 232 188 266 129 168 1477 5 76 M14475 GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 7/15 Gene Ontology BP GO:0009312 0.000177256257062349 0.00223035447571948 230 1013.72727272727 232 1.77270397551119e-05 35 2.01592228752671 2.01592228752671 1 20.290525918879 226 575 4242 455 3588 116 173 35 91 1418 232 77 M15144 GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 80/237 Gene Ontology BP GO:0070374 7.07871646171777e-05 0.0010882940573429 55 249.272727272727 235 6.43540385149572e-06 53 1.69594729794943 1.69594729794943 1 19.0760488067954 53 605 245 344 396 138 99 123 394 235 110 78 M15261 GO_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. 151/410 Gene Ontology BP GO:0050727 2.99525801975441e-06 8.53189140228203e-05 190 352.181818181818 235 2.72296554340802e-07 14 1.27559479140537 1.32982191657477 1 19.7016600517396 189 14 153 181 235 694 452 179 775 359 643 79 M15627 GO_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 14/45 Gene Ontology BP GO:0050704 0.000234551253251317 0.0027362348463464 25 580.636363636364 237 2.13251148618234e-05 21 1.450878806947 1.450878806947 1 14.1143533391881 237 1493 706 1299 400 23 111 206 1692 199 21 80 M16847 GO_INNER_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. 59/188 Gene Ontology BP GO:0042472 1.02638741199165e-06 3.53794148465773e-05 75 441.727272727273 237 9.3307990076588e-08 75 1.57808826184335 1.57808826184335 1 26.6637018360767 75 232 131 227 2287 321 465 237 446 100 338 81 M12192 GO_DETECTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS.html The series of events by which a mechanical stimulus is received and converted into a molecular signal. 29/82 Gene Ontology BP GO:0050982 0.000111487398657409 0.00157815851209253 20 304.090909090909 238 1.01357317094321e-05 18 1.51323045448854 1.51323045448854 1 16.0937440031686 18 394 329 439 238 38 47 142 1330 277 93 82 M10505 GO_COLLAGEN_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_FIBRIL_ORGANIZATION.html Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. 27/60 Gene Ontology BP GO:0030199 4.16134131932084e-07 1.63738201233955e-05 35 251 240 3.7830382785878e-08 33 1.54273640728448 1.64514507030898 1 28.0258014559299 33 77 115 391 340 445 240 207 198 252 463 83 M14319 GO_OLFACTORY_LOBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_LOBE_DEVELOPMENT.html The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. 16/61 Gene Ontology BP GO:0021988 4.61518702624834e-05 0.00078491990340187 220 420 242 4.19571258822938e-06 11 1.17053293904252 1.17053293904252 1 13.7967534541097 216 412 797 562 819 87 75 11 1344 242 55 84 M16714 GO_EXTRACELLULAR_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins. 14/36 Gene Ontology BP GO:0043206 2.43160712573699e-06 7.14553916759294e-05 330 336.181818181818 242 2.21055437576188e-07 5 1.52566378051927 1.52566378051927 1 24.0099744699278 5 814 242 349 328 48 21 329 1261 201 100 85 M14391 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND.html The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. 11/35 Gene Ontology BP GO:0050910 0.000253185768679856 0.00285325612616643 60 349.181818181818 243 2.30195373743477e-05 60 1.46778240338295 1.46778240338295 1 14.1774636206752 60 126 298 640 243 256 238 232 1301 333 114 86 M16020 GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. 6/28 Gene Ontology BP GO:0036151 5.11499877581862e-06 0.00013314768774971 1045 756.909090909091 243 5.11501054930237e-07 4 1.02192717514728 -1.02192717514728 -1 15.0339660020066 1043 309 4495 243 4 185 448 77 81 1342 99 87 M12344 GO_NEPHRIC_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. 16/29 Gene Ontology BP GO:0072176 0.00178785702746029 0.0119096415760375 245 313.181818181818 244 0.000162664691511033 96 1.39060529721723 1.39060529721723 1 10.1563824281438 244 283 617 163 174 794 471 195 271 96 137 88 M10047 GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. 4/18 Gene Ontology BP GO:0036150 0.000506824875775217 0.00494602632702441 355 632.636363636364 245 5.06940505047293e-05 46 1.02192717514728 -1.02192717514728 -1 8.94413172220973 354 451 3523 176 64 170 201 643 46 1086 245 89 M12903 GO_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 221/509 Gene Ontology BP GO:0070482 5.19020711330818e-07 1.94339771186209e-05 225 278.909090909091 246 4.71837121615863e-08 2 1.45536948703347 1.47658296980115 1 26.0275929246061 223 2 121 69 246 487 477 288 744 74 337 90 M11955 GO_REPLACEMENT_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLACEMENT_OSSIFICATION.html Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. 18/52 Gene Ontology BP GO:0036075 7.3100381039978e-05 0.00111280350547088 250 378.636363636364 248 6.64571000835751e-06 68 1.47652604330442 1.47652604330442 1 16.5537847575858 68 539 247 673 454 248 96 108 1314 280 138 91 M10530 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 50/150 Gene Ontology BP GO:0071347 0.00138449134456874 0.00976929074898582 95 491.363636363636 249 0.000125942126645803 94 1.71936828755388 1.71936828755388 1 13.1190320579596 94 2246 460 827 249 218 157 111 296 627 120 92 M15454 GO_ENDOCHONDRAL_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_OSSIFICATION.html Replacement ossification wherein bone tissue replaces cartilage. 18/52 Gene Ontology BP GO:0001958 7.3100381039978e-05 0.00111280350547088 250 380.363636363636 249 6.64571000835751e-06 69 1.47652604330442 1.47652604330442 1 16.5537847575858 69 540 248 674 455 249 97 116 1315 282 139 93 M12319 GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neutrophil migration. 13/50 Gene Ontology BP GO:1902624 0.00207980741953339 0.0133747172422348 240 461.363636363636 252 0.000189252382460303 70 1.17908526180776 1.17908526180776 1 8.38602332516277 252 121 710 340 1698 117 414 239 240 874 70 94 M14182 GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in an epithelial cell. 26/55 Gene Ontology BP GO:1904019 0.000138039310618363 0.00184702166916731 90 365.272727272727 253 1.25498156977554e-05 20 1.57739256409486 1.57739256409486 1 16.367055254629 87 630 403 492 1293 253 153 31 425 231 20 95 M16391 GO_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSPORT.html The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 43/164 Gene Ontology BP GO:0006814 0.00112987352712506 0.0084340880810959 155 642 253 0.000102768565806457 79 1.62228407852443 1.78230914715755 1 12.7712940436105 155 249 741 104 3990 463 468 417 143 79 253 96 M12753 GO_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_INFLAMMATORY_RESPONSE.html Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. 33/158 Gene Ontology BP GO:0002526 7.20850018549497e-05 0.00110458964888624 130 571.363636363636 257 6.55339671763462e-06 70 1.48290673746645 1.48290673746645 1 16.6434316427446 129 70 246 763 1246 257 118 513 1719 1017 207 97 M16906 GO_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS.html The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. 56/161 Gene Ontology BP GO:0042476 2.38133074785971e-07 1.06312679445314e-05 205 573.090909090909 257 2.16484636874589e-08 48 1.48455654303114 1.54001484456492 1 28.0258419685321 201 235 102 257 2586 636 772 191 630 48 646 98 M15227 GO_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MORPHOGENESIS.html The process in which bones are generated and organized. 47/125 Gene Ontology BP GO:0060349 4.61197178514429e-05 0.00078491990340187 255 344 258 4.1927895191726e-06 90 1.46740882093403 1.4760374236016 1 17.2959487457275 251 242 225 258 402 977 625 90 337 102 275 99 M16954 GO_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of vasculature development. 147/372 Gene Ontology BP GO:1901342 5.53025236898906e-12 1.28384808746081e-09 280 288.454545454545 258 5.02750215363904e-13 20 1.55069544709384 1.56079089519708 1 52.3369137901924 27 691 20 74 568 258 276 144 736 99 280 100 M15294 GO_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_FORMATION.html The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 16/51 Gene Ontology BP GO:0060343 4.84068949041619e-06 0.000127700689227286 10 410.909090909091 259 4.40063649225725e-07 6 1.44475336228695 1.44475336228695 1 21.3538082968135 6 644 259 833 856 37 27 340 1289 97 132 101 M12122 GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. 9/29 Gene Ontology BP GO:0048557 0.00257746451077004 0.0157255817654472 320 745.545454545455 266 0.000258045889542954 33 1.65818250371208 1.65818250371208 1 11.3508923840853 316 435 3852 226 992 266 172 167 33 1594 148 102 M13216 GO_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. 39/90 Gene Ontology BP GO:0048546 0.000628352540986624 0.00591772991440344 225 337.636363636364 266 5.71392799600946e-05 98 1.70141208051813 1.70141208051813 1 14.3880416998414 222 709 341 98 205 678 486 175 284 250 266 103 M10208 GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION.html The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. 6/25 Gene Ontology BP GO:0021889 3.9209691781847e-05 0.0006948496142867 270 652.454545454545 267 3.92103836289958e-06 13 1.27570675230677 1.27570675230677 1 15.292737195706 267 443 3553 702 16 51 13 281 1640 181 30 104 M12859 GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT.html The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. 19/54 Gene Ontology BP GO:0048566 0.00111188706742936 0.00836708533885656 265 871 270 0.000101131765151248 97 1.65818250371208 1.65818250371208 1 13.0757039986596 264 1697 914 1173 2391 270 129 97 216 2239 191 105 M13430 GO_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_MIGRATION.html Any process that modulates the frequency, rate or extent of neuron migration. 27/79 Gene Ontology BP GO:2001222 0.000200702454044863 0.00244583069325538 25 619.909090909091 272 1.82473423768285e-05 24 1.37615282945124 1.37615282945124 1 13.6419410889363 24 1587 443 1453 930 184 105 272 1395 253 173 106 M10733 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. 21/59 Gene Ontology BP GO:0050974 0.000685066524727591 0.00633674436917152 40 341.727272727273 273 6.2298176663018e-05 40 1.55588838160164 1.55588838160164 1 12.9819459197919 40 273 365 571 469 53 66 145 1303 328 146 107 M12509 GO_PROTEIN_TRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRIMERIZATION.html The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. 30/65 Gene Ontology BP GO:0070206 0.00072428249342677 0.00655525071536159 105 392.636363636364 274 6.58655501066773e-05 41 1.49055984806853 1.49055984806853 1 12.3535586741864 41 78 411 274 1041 104 81 615 1277 295 102 108 M10653 GO_CELLULAR_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 260/821 Gene Ontology BP GO:0071396 1.28858986709352e-11 2.30112413573661e-09 195 443.818181818182 277 1.17144533372824e-12 26 1.50071489168768 1.5292283817039 1 49.2064050330834 192 687 26 65 1166 674 466 277 990 126 213 109 M14574 GO_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT.html The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 87/290 Gene Ontology BP GO:0045165 2.59594167972846e-05 0.00052177303978265 250 576 277 2.35997482878013e-06 106 1.53733238873011 1.54586160265179 1 19.1550007206528 247 216 201 200 277 1150 720 1647 541 106 1031 110 M15882 GO_NOTOCHORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTOCHORD_DEVELOPMENT.html The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. 24/52 Gene Ontology BP GO:0030903 0.00101032419494854 0.00808781937438975 95 405.636363636364 278 9.18898611828898e-05 89 1.44181934932785 1.44181934932785 1 11.4502442602439 91 89 376 517 673 471 278 246 1309 212 200 111 M12124 GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. 18/40 Gene Ontology BP GO:0060674 0.00860329884667884 0.0365463097393686 325 370.727272727273 281 0.0007851934708794 102 1.35079443411392 1.35079443411392 1 7.36886411024502 321 102 1054 121 350 410 267 770 138 281 264 112 M13053 GO_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DIFFERENTIATION.html The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. 37/95 Gene Ontology BP GO:0002062 5.65172243010895e-07 2.08261486055523e-05 165 353.818181818182 281 5.13793080183367e-08 54 1.59465619750788 1.62026929758064 1 28.3366962876269 162 67 123 318 386 534 281 230 1286 54 451 113 M16155 GO_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 212/571 Gene Ontology BP GO:0097305 1.06253362444889e-15 5.48149290924023e-13 125 375.818181818182 284 9.65939658589898e-17 9 1.49318406387385 1.52880474453571 1 69.4944388264698 125 479 9 184 655 723 232 81 1017 284 345 114 M14579 GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 81/224 Gene Ontology BP GO:0050731 0.000137837656113164 0.00184702166916731 375 422.545454545455 285 1.25314811708712e-05 15 1.44058656060653 1.58719838980128 1 14.9475535597117 124 1362 373 285 181 65 345 112 1412 374 15 115 M12706 GO_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_REMODELING.html The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. 34/78 Gene Ontology BP GO:0046849 0.00266979633823276 0.0161083144290426 100 478.818181818182 286 0.000243003797109087 100 1.18315582880075 1.18315582880075 1 8.05225154568218 100 1374 935 170 1109 283 286 159 397 341 113 116 M16924 GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. 154/418 Gene Ontology BP GO:0043062 1.01400011719036e-15 5.48149290924023e-13 10 410 287 9.21818288354869e-17 8 1.4904615772835 1.51465991860568 1 69.3677312876023 9 485 8 518 958 208 214 287 1381 75 367 117 M11306 GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. 13/24 Gene Ontology BP GO:0060644 0.000916358144456987 0.00765212956885139 430 653.181818181818 288 8.33400049606667e-05 88 1.03190356104762 1.03190356104762 1 8.28908669006042 429 120 1409 288 88 137 285 1060 1293 1932 144 118 M15881 GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 56/141 Gene Ontology BP GO:0007229 0.000927440890355735 0.00771703952315713 45 635.909090909091 288 8.43483724537194e-05 45 1.3119450924807 1.3119450924807 1 10.5203390889415 45 2245 451 1137 993 61 78 98 1444 288 155 119 M16851 GO_ESTROUS_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROUS_CYCLE.html A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. 11/25 Gene Ontology BP GO:0044849 0.00486385761622612 0.0246807550952327 290 608.272727272727 289 0.000443149477259489 102 1.35865580845093 1.35865580845093 1 8.29098071584436 289 1399 1275 867 1127 272 102 249 155 782 174 120 M11151 GO_POSITIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. 254/658 Gene Ontology BP GO:0043410 0.000175668136483102 0.00222241732340883 115 619.454545454545 295 1.59711059093869e-05 111 1.46885416898676 1.46885416898676 1 14.7928450193805 111 1073 279 701 2346 182 295 275 910 493 149 121 M12268 GO_HYALURONAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 21/45 Gene Ontology BP GO:0030212 9.64281561675374e-05 0.00140791172668514 350 446.636363636364 295 8.76658026977292e-06 23 2.04353376858114 2.04353376858114 1 22.1182589254154 346 1648 659 38 766 295 161 23 261 665 51 122 M14434 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. 11/34 Gene Ontology BP GO:0060045 1.16442477826807e-05 0.00027305172957064 425 522.818181818182 296 1.05857358311606e-06 7 1.46445863131043 1.59503604752152 1 19.8103517584587 296 421 423 256 7 540 148 2699 203 142 616 123 M14991 GO_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 86/261 Gene Ontology BP GO:0050920 3.56674333839983e-08 2.02046255596461e-06 300 283 296 3.24249399656868e-09 29 1.32647384112633 1.40490055959224 1 28.6724807595614 51 29 81 259 565 296 297 339 621 274 301 124 M10703 GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS.html The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 73/306 Gene Ontology BP GO:0050954 1.32482480929961e-05 0.000306027939780004 170 509.363636363636 297 1.20439344306399e-06 109 1.75862294992281 1.75862294992281 1 23.4590948849457 166 225 183 596 1611 297 532 176 1405 303 109 125 M14950 GO_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_LINEAGE_COMMITMENT.html The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. 6/16 Gene Ontology BP GO:0002360 0.000765581123377326 0.00680956543264545 305 720.909090909091 303 7.6584500283844e-05 41 1.92006803294693 1.92006803294693 1 15.792788895256 303 1059 4323 204 133 714 443 86 41 506 118 126 M14009 GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. 13/32 Gene Ontology BP GO:0072498 0.000100571776544993 0.00146380802037117 40 422 305 9.14330676564514e-06 39 1.5353065025574 1.5353065025574 1 16.518903435576 39 816 254 381 765 119 126 305 1282 184 371 127 M11822 GO_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_PROLIFERATION.html The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 35/97 Gene Ontology BP GO:0072089 0.00183517535266255 0.0121373401065445 310 357.636363636364 306 0.00016697345383543 135 1.72683545062794 1.72683545062794 1 12.5581507588814 309 256 902 270 135 426 598 306 164 209 359 128 M13740 GO_NEGATIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 101/307 Gene Ontology BP GO:0051048 0.000288057212178636 0.0031768399908442 40 1132.36363636364 306 2.61904487175251e-05 36 1.30698941534041 1.30698941534041 1 12.392888592027 36 1358 306 2439 3756 56 246 143 2392 1640 84 129 M13997 GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. 28/57 Gene Ontology BP GO:0045992 1.60031835694845e-05 0.000353877111986173 150 320.454545454545 306 1.4548454527834e-06 57 1.46146905097812 1.51006188451575 1 19.145220755108 150 266 188 95 408 693 560 352 450 57 306 130 M16019 GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. 4/17 Gene Ontology BP GO:0007171 0.00169455916410978 0.0114192136414538 265 778.909090909091 306 0.000169585274146205 84 1.01763573472543 1.01763573472543 1 7.50291723861516 265 313 4494 411 136 306 213 1118 84 1104 124 131 M14200 GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS.html A multicellular organism process which involves another multicellular organism of the same or different species. 112/337 Gene Ontology BP GO:0044706 6.42023253591342e-11 9.18187948735865e-09 70 309 307 5.83657503281888e-12 32 1.45286380513779 1.49521798270212 1 44.3230666077344 67 206 32 109 732 307 381 562 600 89 314 132 M13912 GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. 5/21 Gene Ontology BP GO:0002921 2.91896071666412e-05 0.000564283240835162 310 1061.36363636364 310 2.91899905886544e-06 5 0.847808867288674 0.847808867288674 1 10.4541430258801 310 909 4155 592 245 108 5 174 1240 3871 66 133 M10907 GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 29/68 Gene Ontology BP GO:0048146 0.00011542868428799 0.0016209598125248 445 507.454545454545 311 1.04940673633682e-05 25 1.45201868929671 1.45201868929671 1 15.3786811032884 442 73 311 25 28 783 387 2265 200 59 1009 134 M10490 GO_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 37/113 Gene Ontology BP GO:0001656 0.000237765970533482 0.00275586597652182 1730 1016.54545454545 312 2.16174246440327e-05 103 1.53622269864354 1.68461817809338 1 14.9264863256913 1726 251 292 110 312 2387 2067 1659 103 224 2051 135 M14352 GO_CYCLOOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLOOXYGENASE_PATHWAY.html The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. 5/22 Gene Ontology BP GO:0019371 0.00362239534235808 0.0200223590173435 180 813.909090909091 312 0.000362831371130828 94 1.29064118907003 1.29064118907003 1 8.32097860395733 180 312 4227 537 962 177 94 844 149 1202 269 136 M13564 GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 105/252 Gene Ontology BP GO:0010952 0.000197025163627628 0.00242649293029994 190 375.363636363636 313 1.79129828001522e-05 36 1.44063912554497 1.51286827439397 1 14.3000518526616 186 209 545 67 399 1051 313 36 733 436 154 137 M14968 GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a humoral immune response. 18/65 Gene Ontology BP GO:0002920 0.00577705276050274 0.0277095619493949 130 408.090909090909 316 0.000526570810902213 66 1.1099059725563 1.1099059725563 1 6.56123085777056 128 641 866 316 412 66 120 388 311 1070 171 138 M10244 GO_REGULATION_OF_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULOGENESIS.html Any process that modulates the frequency, rate or extent of vasculogenesis. 5/21 Gene Ontology BP GO:2001212 0.000463626554624948 0.00460023849838641 260 664.272727272727 318 4.63723310348522e-05 28 1.70820157422404 1.70820157422404 1 15.1546488636423 259 675 3559 336 318 155 28 394 159 1176 248 139 M10509 GO_RESPONSE_TO_ESTRADIOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTRADIOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 82/226 Gene Ontology BP GO:0032355 6.56383228654612e-08 3.54370619842251e-06 320 541.545454545455 318 5.96712043852909e-09 86 1.51277337280268 1.51277337280268 1 31.2983048608703 318 365 86 134 332 1465 272 303 1752 251 679 140 M13089 GO_RENAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_TUBULE_DEVELOPMENT.html The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. 46/137 Gene Ontology BP GO:0061326 2.16956398083663e-07 9.97355006240046e-06 260 358.636363636364 324 1.97233108617414e-08 50 1.50479525177091 1.59674169432133 1 28.566336232139 258 244 99 206 401 725 395 637 324 50 606 141 M14103 GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 14/30 Gene Ontology BP GO:0018146 0.000720610953921468 0.00655142673033326 1155 716 324 6.55315544225463e-05 102 1.61869866559941 1.68279153288838 1 13.4171129654853 1153 114 350 102 107 1533 1596 324 180 198 2219 142 M15042 GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of muscle tissue development. 33/88 Gene Ontology BP GO:1901863 0.000411584403183379 0.00419067929966216 280 419.818181818182 324 3.74237658308641e-05 95 1.43624646841403 1.49683314937018 1 12.9627190135378 279 711 324 234 95 697 536 758 658 190 136 143 M12465 GO_EAR_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_DEVELOPMENT.html The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 112/339 Gene Ontology BP GO:0043583 7.42031068849465e-09 5.46865119471122e-07 65 389.454545454545 326 6.74573701229305e-10 32 1.58905913050305 1.62288275785094 1 37.7718850444605 66 205 63 64 1755 387 326 450 518 32 418 144 M16771 GO_INTESTINAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_ABSORPTION.html Any process in which nutrients are taken up from the contents of the intestine. 17/58 Gene Ontology BP GO:0050892 0.00446573079349881 0.0232448296796132 80 545.272727272727 329 0.000406801956851711 80 1.45324419107198 1.45324419107198 1 9.01179131153535 80 411 870 329 874 273 243 208 358 2164 188 145 M10489 GO_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 85/264 Gene Ontology BP GO:0050808 2.85161766507632e-05 0.000561019526226667 210 421.636363636364 331 2.59241329829613e-06 31 1.47238964778434 1.44344840860873 1 18.1697895793734 99 31 206 207 1411 453 410 331 551 177 762 146 M12965 GO_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 31/83 Gene Ontology BP GO:0061383 0.000302056933865087 0.00329988316220141 35 611.818181818182 333 2.74634921667771e-05 32 1.44475336228695 1.44475336228695 1 13.6086635140567 32 947 570 974 1770 139 85 333 1336 310 234 147 M14620 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 37/87 Gene Ontology BP GO:0071230 6.13150335708214e-05 0.000968318710439876 110 324.363636363636 336 5.57424931966312e-06 107 1.49141470073108 1.49141470073108 1 17.0626411986587 107 254 239 293 366 565 336 131 441 401 435 148 M13189 GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of stem cell differentiation. 36/92 Gene Ontology BP GO:2000738 1.19734866195971e-06 3.91499284329501e-05 95 577.090909090909 337 1.08849937601499e-07 66 1.28870468605354 1.35090018289018 1 21.5590788160055 92 66 137 593 337 978 1238 271 1926 217 493 149 M14199 GO_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSSIFICATION.html The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. 166/459 Gene Ontology BP GO:0001503 0.000540579882669204 0.00517507710357343 250 534.909090909091 339 4.91557053325975e-05 173 1.46445580174385 1.47782273850492 1 12.7079508777301 249 925 339 219 1469 853 490 215 642 173 310 150 M15958 GO_TELENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. 135/430 Gene Ontology BP GO:0021537 5.98755862216296e-06 0.00015027153882542 340 423.909090909091 339 5.44324992551792e-07 18 1.43659241517358 1.50100974812476 1 20.8477457105104 339 18 172 231 845 822 676 469 830 66 195 151 M16891 GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. 14/55 Gene Ontology BP GO:0090022 0.00321265885721053 0.0183473248143032 460 483.272727272727 339 0.000292487265001437 117 1.17908526180776 1.17908526180776 1 7.77157485935177 458 117 948 339 187 477 1221 307 207 926 129 152 M11227 GO_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DIFFERENTIATION.html The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. 104/262 Gene Ontology BP GO:0001649 0.00109945016496701 0.00830040181453953 235 477.272727272727 347 1e-04 97 1.48819283387311 1.51108549963951 1 11.754870109596 231 1357 543 97 722 623 262 347 659 292 117 153 M13178 GO_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that modulates the frequency, rate or extent of response to wounding. 236/603 Gene Ontology BP GO:1903034 2.39895833193004e-10 2.47519189670026e-08 170 453.818181818182 348 2.1808712110833e-11 13 1.42925693652386 1.49498103512279 1 41.2663628967215 169 183 45 13 646 905 654 348 791 221 1017 154 M10077 GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. 29/69 Gene Ontology BP GO:0007528 0.00120282060933028 0.00887869012578774 50 508.545454545455 349 0.000109407158112529 49 1.36458725573928 1.34431737775295 1 10.6270335006569 49 262 453 705 989 162 257 389 1704 275 349 155 M13475 GO_RESPONSE_TO_ESTROGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTROGEN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 127/351 Gene Ontology BP GO:0043627 3.36365582356151e-10 3.32286255080768e-08 295 438.727272727273 350 3.05786893097798e-11 47 1.51119989113204 1.51119989113204 1 42.8985807133454 293 350 47 194 406 1162 432 342 799 154 647 156 M10502 GO_FOCAL_ADHESION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOCAL_ADHESION_ASSEMBLY.html The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. 22/40 Gene Ontology BP GO:0048041 0.00044977081710455 0.00450061617201816 190 408.454545454545 352 4.08966177411966e-05 61 1.8852765158377 1.8852765158377 1 16.79364808956 187 1280 493 129 617 414 570 61 118 352 272 157 M11382 GO_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins. 22/47 Gene Ontology BP GO:0097435 3.1151712494439e-05 0.000585576522719354 10 574.909090909091 354 2.83201396430559e-06 10 1.52566378051927 1.52566378051927 1 18.7194619256569 10 2066 441 703 1202 57 18 105 1291 354 77 158 M16913 GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 113/273 Gene Ontology BP GO:0010770 0.000362139000885999 0.00381439287373692 180 629.454545454545 354 3.29271478031274e-05 177 1.36037666286357 1.4078129921555 1 12.4889488722144 177 354 315 826 1619 585 678 283 1406 338 343 159 M12684 GO_PONS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PONS_DEVELOPMENT.html The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. 6/20 Gene Ontology BP GO:0021548 0.000186150528937387 0.00233593758339538 360 1518.63636363636 356 1.86166124184766e-05 38 2.24458518468169 2.24458518468169 1 22.4209027639105 356 4078 3949 2607 3548 245 254 38 144 1320 166 160 M12990 GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 136/352 Gene Ontology BP GO:0070372 0.00106500635361041 0.00830040181453953 90 371.090909090909 356 9.68656605694635e-05 88 1.51542991459211 1.51542991459211 1 11.9700091283669 88 927 382 367 250 284 356 107 598 540 183 161 M16105 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. 88/216 Gene Ontology BP GO:1903035 3.01133953541898e-07 1.24836155919199e-05 250 478.363636363636 356 2.7375817705531e-08 18 1.54609251105376 1.64616325832663 1 28.7781600551141 246 215 109 18 957 1200 674 356 430 192 865 162 M14304 GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction. 22/40 Gene Ontology BP GO:0007045 0.000534475592774077 0.00512721111002074 190 410.636363636364 357 4.86004985727419e-05 71 1.8852765158377 1.8852765158377 1 16.388541334869 188 1281 494 130 618 415 571 71 119 357 273 163 M11573 GO_OVULATION_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE.html The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 61/155 Gene Ontology BP GO:0042698 0.00236383884151671 0.0146728659641204 210 436.272727272727 360 0.000215125686169144 208 1.62464765939855 1.65400969220764 1 11.3069063036578 564 375 436 208 221 864 964 273 360 208 326 164 M12187 GO_DIGESTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 94/259 Gene Ontology BP GO:0055123 3.90765185717838e-09 3.2987686496144e-07 365 476.909090909091 361 3.55241078556288e-10 25 1.49629221394181 1.54068970674085 1 36.8136686175051 351 361 55 87 300 1501 990 361 510 25 705 165 M13009 GO_TERPENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERPENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. 35/174 Gene Ontology BP GO:0006721 8.35660037858958e-05 0.0012530865137203 280 460.727272727273 364 7.59719801559262e-06 17 1.39686300240301 1.59707913987393 1 15.3872598844483 277 945 412 804 1228 561 32 17 340 364 88 166 M14023 GO_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 69/211 Gene Ontology BP GO:0042471 1.08408620880243e-07 5.47110029072792e-06 540 486.454545454545 364 9.8553296565688e-09 59 1.59703114829434 1.59703114829434 1 31.8981354681323 59 226 92 286 2220 364 539 480 537 88 460 167 M14946 GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 84/207 Gene Ontology BP GO:0051896 0.000455954060831903 0.00455267678374737 35 381.727272727273 364 4.14589623254875e-05 35 1.5276055111058 1.5276055111058 1 13.5786269602643 35 496 583 298 301 152 364 408 597 867 98 168 M15944 GO_ARACHIDONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. 16/110 Gene Ontology BP GO:0019369 6.25414786379444e-05 0.000977710724969616 280 502.363636363636 366 5.68575060312838e-06 19 1.65216831739531 1.65216831739531 1 18.8754650715453 278 282 366 182 19 604 454 1139 263 1010 929 169 M15995 GO_MESENCHYME_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_MORPHOGENESIS.html The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. 23/58 Gene Ontology BP GO:0072132 2.9603622786196e-05 0.000564283240835162 3190 1688.90909090909 367 2.69127464961254e-06 78 1.38975168558134 1.46900808347127 1 17.1367196690032 3190 92 210 332 78 3087 2316 4396 367 196 4314 170 M12042 GO_NEGATIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COAGULATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. 24/67 Gene Ontology BP GO:0050819 2.09299000854247e-06 6.2695178126856e-05 60 542.727272727273 369 1.90271999975473e-07 57 1.85222510855172 1.95364542689044 1 29.5485513441734 57 720 147 851 2025 229 287 117 369 747 421 171 M15732 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY.html Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. 4/17 Gene Ontology BP GO:0010715 3.52395603479036e-05 0.000636242041201233 460 712.363636363636 370 3.5240119182352e-06 2 1.73924633763958 1.73924633763958 1 21.102135732346 460 160 4449 100 14 476 283 959 2 370 563 172 M16106 GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT.html The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. 4/18 Gene Ontology BP GO:0021891 0.000167279336089215 0.00216344834947695 495 797.727272727273 371 1.67291929492752e-05 35 1.30628405292381 1.30628405292381 1 13.2135097573072 492 315 4508 506 35 136 68 535 1639 371 170 173 M10687 GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. 31/54 Gene Ontology BP GO:0045599 0.000171477313283451 0.00217532558900291 170 411.545454545455 372 1.55900618554395e-05 33 1.2874543857575 1.2874543857575 1 13.0114213214742 167 391 372 829 578 320 197 33 783 548 309 174 M14668 GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. 134/297 Gene Ontology BP GO:2001234 0.000123332111036293 0.0016941745311879 375 338.636363636364 372 1.12126386893955e-05 14 1.47566114100385 1.52368432639503 1 15.5216167939559 372 599 446 159 193 431 342 42 752 375 14 175 M13750 GO_GLYCINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycine, aminoethanoic acid. 6/20 Gene Ontology BP GO:0006544 0.000421483392002359 0.00425423345449337 375 856.727272727273 373 4.21563355060861e-05 63 1.59008010255122 -1.59008010255122 -1 14.3116766632487 373 840 4128 1196 691 96 249 63 343 1326 119 176 M10621 GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 29/68 Gene Ontology BP GO:0010718 9.84340779134674e-06 0.000233178277424607 125 540.363636363636 376 8.948592576135e-07 74 1.24262315307188 1.30712064474494 1 17.1328576743974 121 74 180 538 298 1046 807 376 1675 276 553 177 M12368 GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. 26/79 Gene Ontology BP GO:1903018 0.0036576067960671 0.0201211710357104 255 763.090909090909 377 0.000333063812409017 188 1.91554149658877 1.91554149658877 1 12.3342692910728 269 2526 801 954 1752 251 377 188 253 809 214 178 M16501 GO_RESPONSE_TO_UV_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_B.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. 7/19 Gene Ontology BP GO:0010224 0.00588690341123241 0.0281202598131194 565 855.636363636364 377 0.000590255683892633 69 1.31641291864241 1.31641291864241 1 7.75007226647262 96 1455 4572 1246 377 69 169 564 82 562 220 179 M16350 GO_RESPONSE_TO_WATER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. 12/31 Gene Ontology BP GO:0009415 2.30394721109931e-05 0.000473328623943986 105 568.909090909091 378 2.09451939955548e-06 6 1.5813736293525 1.5813736293525 1 19.9577745558385 101 1911 956 1362 378 128 88 6 455 826 47 180 M16783 GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 62/155 Gene Ontology BP GO:0010717 0.000396076058262334 0.00407756350002665 295 618.454545454545 378 3.60133985112754e-05 42 1.35508782865517 1.41148254038465 1 12.2913547095627 291 42 321 378 919 1392 1175 223 1316 215 531 181 M10985 GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. 12/23 Gene Ontology BP GO:2000050 0.0002500034818982 0.00283113699134961 380 339.272727272727 380 2.27301723910085e-05 40 1.43881158816123 1.75395111196218 1 13.9160906384557 561 414 492 241 45 593 399 189 40 380 378 182 M11332 GO_GANGLIOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 11/27 Gene Ontology BP GO:0001573 0.0158429690676227 0.0562376952453916 385 781.909090909091 381 0.00145074759057269 130 1.54049643392023 1.54049643392023 1 7.30917536763576 383 130 676 175 3978 381 378 1270 251 768 211 183 M13085 GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION.html The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. 8/16 Gene Ontology BP GO:0071425 0.000218768043153241 0.00261115687496272 45 689.181818181818 383 2.18789582893216e-05 41 1.91021908880517 1.91021908880517 1 18.7302209969902 503 744 4009 85 41 460 383 310 45 619 382 184 M12723 GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 114/303 Gene Ontology BP GO:0050730 0.000675757554379099 0.00628765996990412 385 528.636363636364 384 6.14513828253805e-05 161 1.44142120813817 1.63212048082388 1 12.0453379472088 384 1004 344 161 167 840 1196 436 691 350 242 185 M12531 GO_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 26/57 Gene Ontology BP GO:0034333 0.00135950646143766 0.00969112621539502 300 403.818181818182 387 0.00012366793692425 109 1.8852765158377 1.8852765158377 1 14.4099025933673 297 794 684 133 387 552 646 109 136 450 254 186 M16051 GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE.html The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. 89/250 Gene Ontology BP GO:0048754 3.83244089728649e-07 1.53396750742252e-05 215 450.090909090909 387 3.48403778627726e-08 61 1.63212789104186 1.70506981122046 1 29.8252496895329 212 604 113 160 761 1205 573 387 370 61 505 187 M12230 GO_NEGATIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WOUND_HEALING.html Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 31/82 Gene Ontology BP GO:0061045 2.96543421847468e-05 0.000564283240835162 345 554.727272727273 389 2.69588562822515e-06 211 1.75961374232975 1.95364542689044 1 21.6974066237469 341 389 211 320 1351 845 579 344 349 549 824 188 M13352 GO_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULUS_DEVELOPMENT.html The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. 36/90 Gene Ontology BP GO:0032835 1.00610233466097e-10 1.22929819469233e-08 25 406.272727272727 389 9.14638486097254e-12 21 1.7620536635118 1.7620536635118 1 52.9080388500841 21 516 38 457 689 209 235 1300 389 105 510 189 M10419 GO_ORGAN_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_REGENERATION.html The regrowth of a lost or destroyed organ. 58/128 Gene Ontology BP GO:0031100 0.000457932150595283 0.00456261582663927 140 399.363636363636 393 4.163886340058e-05 27 1.1404307275486 1.1404307275486 1 10.1329959903472 140 233 742 397 226 557 250 393 668 760 27 190 M13657 GO_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE.html The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. 240/732 Gene Ontology BP GO:0006954 1.06479074291413e-12 3.80294109180791e-10 105 669.090909090909 395 9.67991584467854e-14 13 1.46667313873172 1.49436561263862 1 52.4428104907968 103 1139 13 846 2550 492 373 258 955 236 395 191 M13017 GO_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 36/99 Gene Ontology BP GO:0043550 0.000650645280190923 0.00609061700791624 400 597.181818181818 396 5.91670715316532e-05 69 1.41763221755899 1.41763221755899 1 11.9209520670165 396 255 705 79 69 1310 925 1184 185 392 1069 192 M13309 GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 production. 28/103 Gene Ontology BP GO:0032652 0.000241601783118329 0.00279044049507065 880 522.636363636364 396 2.19662108784262e-05 42 1.45677160827549 1.45677160827549 1 14.1245699453535 876 396 469 230 42 791 975 242 1319 266 143 193 M16856 GO_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 13/37 Gene Ontology BP GO:0010453 0.00109945016496701 0.00830040181453953 390 460 400 1e-04 28 1.44168393364086 -1.34402227147283 -1 11.3875077162725 1068 653 402 28 236 386 244 390 400 412 841 194 M11553 GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 113/320 Gene Ontology BP GO:0071229 3.01327510494082e-09 2.63974270042269e-07 165 502 401 2.73934100824365e-10 20 1.48976640195595 1.48976640195595 1 37.200452206686 165 20 53 84 612 1464 939 401 857 166 761 195 M12201 GO_TAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAXIS.html The directed movement of a motile cell or organism in response to an external stimulus. 219/733 Gene Ontology BP GO:0042330 3.5388597038794e-12 1.0269328503195e-09 110 338.909090909091 402 3.21714518535008e-13 16 1.45507443788187 1.45512676869 1 49.6452421735171 108 189 16 183 424 402 474 580 743 114 495 196 M11168 GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. 17/51 Gene Ontology BP GO:0034122 8.74345437260206e-05 0.00129286174050928 275 1118.27272727273 403 7.94891080256474e-06 20 1.5272541759897 1.5272541759897 1 16.7449206264043 272 3539 1824 1177 3215 247 403 20 350 1037 217 197 M14053 GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell. 24/77 Gene Ontology BP GO:0050710 0.000170168991686274 0.00217279759769568 90 574.545454545455 403 1.54711050550293e-05 32 1.22991998813031 1.22991998813031 1 12.4323181086512 90 403 483 1390 499 124 114 32 1745 1354 86 198 M12687 GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE.html The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. 6/60 Gene Ontology BP GO:0050912 1.09843472012377e-06 3.66908806153574e-05 10 716.363636363636 405 1.09843526307563e-07 1 1.52856505399377 1.52856505399377 1 25.7352297016128 97 1132 3950 462 405 9 6 58 1259 501 1 199 M14474 GO_DETECTION_OF_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_ABIOTIC_STIMULUS.html The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. 70/227 Gene Ontology BP GO:0009582 0.000243764821305793 0.00280148531020494 295 553.363636363636 407 2.21628941066156e-05 95 1.42603413102617 1.42603413102617 1 13.8172589974791 95 1269 294 1103 849 407 352 524 728 175 291 200 M14192 GO_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REMODELING.html The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. 74/161 Gene Ontology BP GO:0048771 0.000160657496718804 0.00208361105381398 165 631.636363636364 410 1.46062936467661e-05 122 1.17824551988702 1.19668957335266 1 11.9913903751506 161 1006 275 626 1492 285 320 122 1771 480 410 201 M11993 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 15/33 Gene Ontology BP GO:0044253 0.000270234481957857 0.00300167153045533 680 423.363636363636 413 2.45697892373223e-05 19 1.57079973463977 1.61620759893924 1 15.0412102859663 680 108 413 19 48 1459 437 492 43 83 875 202 M14175 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. 32/51 Gene Ontology BP GO:0014911 0.00904332557718619 0.0376913470869618 320 812 413 0.000825519494456488 104 1.71588157465315 1.86110880910386 1 9.27322554907926 104 3462 614 881 1713 394 277 413 316 320 438 203 M16187 GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. 15/33 Gene Ontology BP GO:0010714 0.000270234481957857 0.00300167153045533 685 425.363636363636 414 2.45697892373223e-05 20 1.57079973463977 1.61620759893924 1 15.0412102859663 681 109 414 20 49 1460 438 504 44 84 876 204 M13436 GO_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 66/188 Gene Ontology BP GO:0070555 0.00816364342242241 0.0353910330628452 165 680.181818181818 415 0.000744917722986733 164 1.71936828755388 1.71936828755388 1 9.47055670222235 164 2483 553 1010 357 596 415 282 377 903 342 205 M16368 GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving mucopolysaccharide. 56/130 Gene Ontology BP GO:1903510 0.000412479095400734 0.00419067929966216 700 594.636363636364 415 3.75051319652225e-05 12 1.65733950282222 1.69032799412075 1 14.9581751862431 698 378 325 12 823 1769 787 157 415 289 888 206 M10068 GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0052192 0.00621055990364799 0.0291563494768833 115 592.818181818182 416 0.000566196527841893 112 1.30573381359741 1.46979620985367 1 7.60931837294187 112 2051 601 1272 416 219 183 250 660 429 328 207 M10524 GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0051806 0.00484019048608485 0.0246414522224693 220 590.818181818182 417 0.000440988385440969 113 1.30573381359741 1.46979620985367 1 7.97146317477465 113 2052 602 1273 417 220 184 218 661 430 329 208 M12914 GO_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_ENTRY_INTO_HOST_CELL.html The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. 54/135 Gene Ontology BP GO:0046718 0.00576554497795005 0.0276829631154313 115 593.727272727273 418 0.000525519129613206 114 1.30573381359741 1.46979620985367 1 7.72093819353261 114 2053 603 1274 418 221 185 240 662 431 330 209 M12938 GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction. 54/135 Gene Ontology BP GO:0051828 0.00576554497795005 0.0276829631154313 115 594.727272727273 419 0.000525519129613206 115 1.30573381359741 1.46979620985367 1 7.72093819353261 115 2054 604 1275 419 222 186 241 663 432 331 210 M13300 GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 491/1400 Gene Ontology BP GO:0014070 5.01330229998813e-16 4.65535251576898e-13 105 504.818181818182 419 4.55754754544374e-17 5 1.32882763337644 1.39495832621183 1 62.2029623789857 295 333 5 105 1145 899 549 654 1045 104 419 211 M13602 GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS.html The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. 53/145 Gene Ontology BP GO:0044236 6.68803354997976e-08 3.56925744512138e-06 60 469.272727272727 419 6.08003068481545e-09 58 1.35899419434145 1.43877788257193 1 28.100617467809 58 238 87 390 654 737 344 542 419 1027 666 212 M12132 GO_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGING.html A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). 170/435 Gene Ontology BP GO:0007568 4.54255955378993e-07 1.74306644696253e-05 195 608 420 4.12960044703436e-08 118 1.30153348841961 1.36231674285324 1 23.5098377679262 366 195 118 420 888 1948 705 193 1028 262 565 213 M15136 GO_MOVEMENT_IN_HOST_ENVIRONMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_HOST_ENVIRONMENT.html The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0052126 0.00692423340984005 0.0312859209777283 120 597.818181818182 420 0.000631465737238499 116 1.30573381359741 1.46979620985367 1 7.4575757979947 116 2055 605 1276 420 223 187 265 664 433 332 214 M15286 GO_ENTRY_INTO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST.html Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0044409 0.00557276088088022 0.0270212638072061 120 595.909090909091 421 0.000507902486895005 117 1.30573381359741 1.46979620985367 1 7.77301413937536 117 2056 606 1277 421 224 188 234 665 434 333 215 M10360 GO_BONE_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. 12/39 Gene Ontology BP GO:0061430 5.58684919009312e-05 0.000910855220952734 425 633.636363636364 422 5.07908279262027e-06 14 1.46778240338295 1.46778240338295 1 16.9403020624856 14 1335 422 1229 1107 232 140 360 1327 379 425 216 M16749 GO_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST_CELL.html The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 54/135 Gene Ontology BP GO:0030260 0.00509614483559849 0.0253630798097571 225 596 422 0.000464362556483183 118 1.30573381359741 1.46979620985367 1 7.90933192339612 118 2057 607 1278 422 225 189 225 666 435 334 217 M11506 GO_TOOTH_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOOTH_MINERALIZATION.html The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. 13/32 Gene Ontology BP GO:0034505 0.000260035741064508 0.00290926733918677 75 441.909090909091 423 2.36424074429754e-05 71 1.47652604330442 1.47652604330442 1 14.214600021145 71 417 303 434 311 473 487 423 1276 183 483 218 M14612 GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. 44/143 Gene Ontology BP GO:0002688 1.47703283223729e-05 0.000332543923276389 330 423.636363636364 424 1.34276613528388e-06 147 1.13635968837638 1.21677062131389 1 15.0027710078518 327 246 186 328 475 644 431 147 613 839 424 219 M12034 GO_AORTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_DEVELOPMENT.html The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. 38/106 Gene Ontology BP GO:0035904 2.27276464190925e-05 0.000471000118176509 295 659.181818181818 427 2.06617101964405e-06 68 1.46800140765598 1.62091172044007 1 18.538891409117 294 68 195 427 118 2075 648 799 1329 128 1170 220 M11036 GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 36/90 Gene Ontology BP GO:0051965 0.0209596396417449 0.0680135015242823 285 723.090909090909 430 0.00192382082486959 230 1.52792159932447 1.53006428348675 1 6.77064121434958 282 1097 664 263 1328 430 307 2116 230 391 846 221 M12594 GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 94/241 Gene Ontology BP GO:0071453 0.000721318188543184 0.00655142673033326 310 469 430 6.55958906478474e-05 83 1.53795239958062 1.53795239958062 1 12.7478211474629 307 930 624 384 210 530 430 83 804 734 123 222 M13739 GO_MAMMARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. 84/219 Gene Ontology BP GO:0030879 0.000523848966565582 0.00507772599533194 500 620.727272727273 431 4.76339766817515e-05 28 1.27406427793051 1.31526491311933 1 11.0956971354358 500 28 335 246 256 494 559 2853 431 264 862 223 M12381 GO_PATTERNING_OF_BLOOD_VESSELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERNING_OF_BLOOD_VESSELS.html The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. 30/76 Gene Ontology BP GO:0001569 0.000297933661705976 0.00326251413042653 30 492.363636363636 432 2.70885469856527e-05 29 1.64514507030898 1.64514507030898 1 15.527114032418 29 1275 432 842 571 73 57 194 1318 524 101 224 M13627 GO_ORGAN_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_INDUCTION.html The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. 5/25 Gene Ontology BP GO:0001759 0.000154742510585167 0.00201251954242837 535 937.545454545455 433 1.54753287001371e-05 5 1.86235441726781 1.86235441726781 1 19.0603695286133 533 2724 4108 433 381 206 14 460 5 1198 251 225 M15872 GO_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 66/188 Gene Ontology BP GO:0072006 7.18849708748067e-11 9.81652705210963e-09 275 647.363636363636 434 6.53499735246867e-12 34 1.58498815049014 1.68377852852936 1 48.179201755178 271 228 34 315 631 1222 819 1826 434 73 1268 226 M16710 GO_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 90/182 Gene Ontology BP GO:0042542 0.000115960279700543 0.0016209598125248 335 473.909090909091 435 1.05423993024803e-05 80 1.58712748809348 1.58712748809348 1 16.8096510668873 333 362 260 435 80 955 397 530 710 462 689 227 M16970 GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of stem cell differentiation. 84/226 Gene Ontology BP GO:2000736 6.44137864210921e-05 0.00100024485067937 440 728.363636363636 440 5.85597022447798e-06 172 1.46387946934734 1.51994103251291 1 16.6693403286498 440 364 241 627 949 2187 1663 197 421 172 751 228 M11359 GO_ARTERY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_DEVELOPMENT.html The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. 56/156 Gene Ontology BP GO:0060840 4.12200091569995e-06 0.000110626880067022 200 623.090909090909 443 3.74728058077521e-07 46 1.46800140765598 1.62091172044007 1 22.0447552857631 199 46 163 355 443 1509 653 754 1359 287 1086 229 M14729 GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. 105/287 Gene Ontology BP GO:0001763 6.65066126670951e-07 2.41242345791658e-05 125 540 443 6.0460575247489e-08 88 1.63212789104186 1.70506981122046 1 28.607024706369 306 357 125 88 739 1706 852 443 457 125 742 230 M15223 GO_SENSORY_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. 257/760 Gene Ontology BP GO:0007423 1.90098036832537e-08 1.19273673650469e-06 295 562.272727272727 444 1.72816398613764e-09 20 1.5134720338973 1.61374323268882 1 34.0295929806424 292 181 74 350 1314 1104 729 444 731 20 946 231 M12408 GO_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_DEVELOPMENT.html The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. 97/277 Gene Ontology BP GO:0060348 0.00263109556246409 0.0159688584268245 215 810.727272727273 445 0.000239477046047652 164 1.49855508344285 1.50692459779031 1 10.2202572174159 606 213 445 212 1097 2618 1856 266 428 164 1013 232 M12513 GO_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 4/33 Gene Ontology BP GO:0042417 2.02014591349389e-06 6.1123172781594e-05 4165 1855.72727272727 446 2.02014774994152e-07 3 1.48369148420437 -1.03069309216194 -1 23.7314430228414 4163 319 3921 188 3 3656 3272 446 67 368 4010 233 M12538 GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. 35/94 Gene Ontology BP GO:0003229 1.77471189084844e-06 5.4933248728062e-05 450 714.818181818182 448 1.61337574771588e-07 49 1.5779378663223 1.35968216353489 1 25.5166419948869 413 386 144 406 449 1422 696 2291 448 49 1159 234 M10763 GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 26/78 Gene Ontology BP GO:0090218 0.000207275842609475 0.00250620244071821 255 417 449 1.88450339951903e-05 37 1.35507479481972 1.35507479481972 1 13.3785225228672 253 398 633 233 37 582 521 775 214 449 492 235 M14448 GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. 15/36 Gene Ontology BP GO:0060351 0.000753719411115504 0.00673526370294295 45 617.636363636364 449 6.85434326460389e-05 42 1.46778240338295 1.46778240338295 1 12.099232421163 42 811 449 800 990 366 166 409 1936 474 351 236 M14522 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 26/45 Gene Ontology BP GO:1902042 0.00109945016496701 0.00830040181453953 190 558.090909090909 451 1e-04 59 1.6241837693592 1.80777235942664 1 12.829029147565 721 1163 891 59 432 1141 617 186 291 451 187 237 M12839 GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. 12/25 Gene Ontology BP GO:0060716 0.001058589863643 0.00830040181453953 475 529 464 9.62817796691795e-05 98 1.4787559468286 1.4787559468286 1 11.6803304538982 474 295 1230 409 98 464 202 1134 133 820 560 238 M13988 GO_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_PROCESS.html A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 35/119 Gene Ontology BP GO:0022600 0.00348710646050986 0.0194598981924847 180 954.454545454545 464 0.000317513271771725 135 1.45324419107198 1.45324419107198 1 9.43756935486491 179 1636 464 907 1710 156 204 435 2054 2619 135 239 M11609 GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 448/1229 Gene Ontology BP GO:1901701 7.27415426083036e-12 1.46843035795806e-09 330 682.636363636364 465 6.61286750986764e-13 23 1.4067824409627 1.5211259841291 1 47.1682333691972 326 465 23 265 1255 1436 734 404 1553 191 857 240 M13728 GO_FEMALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_SEX_DIFFERENTIATION.html The establishment of the sex of a female organism by physical differentiation. 66/166 Gene Ontology BP GO:0046660 0.000227037129083562 0.00267546545770299 1905 1240.36363636364 465 2.06418693095165e-05 149 1.65903770957168 1.84661555485004 1 16.2007777408395 1901 371 290 405 171 3461 1555 2535 465 149 2341 241 M14413 GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE.html The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein. 10/36 Gene Ontology BP GO:0072661 0.00142455907280163 0.00999113314352954 110 647.454545454545 465 0.000129589304558781 106 1.57385905777205 1.57385905777205 1 11.9505175288713 106 1289 1466 1168 465 135 218 115 1267 728 165 242 M13415 GO_BLOOD_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. 220/539 Gene Ontology BP GO:0048514 1.63751202093538e-09 1.49077810062804e-07 900 577.545454545455 471 1.48864729286747e-10 51 1.50095939698902 1.56671802654598 1 38.8937487444253 64 188 51 471 1322 881 411 897 896 228 944 243 M15221 GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of embryonic development. 68/180 Gene Ontology BP GO:0045995 9.47855637457004e-07 3.30894265016005e-05 420 465.727272727273 472 8.61687314395147e-08 12 1.44994681696175 1.51731262723204 1 24.6585447247661 417 608 130 58 472 1487 636 221 480 12 602 244 M12378 GO_PALATE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALATE_DEVELOPMENT.html The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. 67/155 Gene Ontology BP GO:0060021 6.06100735833074e-06 0.000151297081530804 475 830.818181818182 475 5.51002186953699e-07 38 1.28048301078644 1.28943648732916 1 18.567938067965 475 38 173 443 304 2370 1367 1102 1782 78 1007 245 M10989 GO_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 428/1046 Gene Ontology BP GO:0043549 0.000326724080507634 0.00353608369649638 280 638.727272727273 476 2.97066011546087e-05 212 1.42964821068358 1.4627389497961 1 13.3034512146922 276 1352 312 567 1554 465 476 231 989 592 212 246 M13039 GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. 57/171 Gene Ontology BP GO:0071774 0.00140641281304886 0.0098837302951788 245 611.909090909091 476 0.000127937518917703 119 1.54170326085198 1.54170326085198 1 11.7338230661798 241 2094 788 883 119 607 236 375 751 476 161 247 M15430 GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION.html The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. 183/616 Gene Ontology BP GO:0048667 1.33834852625422e-05 0.000306106020068884 140 594.818181818182 479 1.2166878800329e-06 47 1.56231954912994 1.57429381794431 1 20.8398548842634 137 1140 184 479 2061 421 587 238 748 47 501 248 M12415 GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. 26/50 Gene Ontology BP GO:0048745 0.000802658799884353 0.00697892286116676 205 751.363636363636 480 7.29956177753879e-05 168 1.49607888861834 1.49607888861834 1 12.2448397038217 204 2017 357 1109 1282 586 168 415 1418 229 480 249 M14824 GO_HEART_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_FORMATION.html The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. 7/21 Gene Ontology BP GO:0060347 0.00329076254543228 0.0187013592392192 390 1209.54545454545 484 0.000329564582916026 90 1.39869528009495 1.39869528009495 1 9.17499745815411 386 1347 4298 1088 4338 165 90 484 314 557 238 250 M16953 GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 134/317 Gene Ontology BP GO:0000302 3.4502801458886e-06 9.64321203268244e-05 525 549.272727272727 488 3.13662323364221e-07 144 1.45247884971564 1.52804595170669 1 22.1404668995429 525 349 156 279 144 1289 488 506 839 376 1091 251 M10380 GO_ANTIMICROBIAL_HUMORAL_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIMICROBIAL_HUMORAL_RESPONSE.html An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. 40/176 Gene Ontology BP GO:0019730 0.00364858704124408 0.0201211710357104 470 732.818181818182 490 0.000332241102024657 111 1.20074158169684 -1.20074158169684 -1 7.73163622082081 352 874 466 1421 477 111 706 490 648 2050 466 252 M15889 GO_SKIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_DEVELOPMENT.html The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. 118/353 Gene Ontology BP GO:0043588 3.32464363641057e-08 1.92954005048178e-06 490 605.090909090909 490 3.02240335150239e-09 80 1.41965462735643 1.48313662231922 1 30.7943953992483 239 490 80 488 2186 575 713 652 802 115 316 253 M16933 GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. 232/511 Gene Ontology BP GO:2001233 0.00050706623555107 0.00494602632702441 990 835.363636363636 490 4.61075585692587e-05 28 1.39757616989996 1.47801478726316 1 12.2318944631956 989 478 916 225 360 3195 1125 457 926 490 28 254 M10255 GO_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 30/64 Gene Ontology BP GO:0010883 0.00468149909292529 0.0240710966649525 90 969.727272727273 491 0.000426499171625748 89 1.39074769531634 1.39074769531634 1 8.54416034650506 89 1640 491 1292 3975 205 359 317 922 931 446 255 M10809 GO_NEURON_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. 21/65 Gene Ontology BP GO:0042551 0.00602901908519878 0.0285348986876432 495 885.181818181818 494 0.000549600459981945 119 1.52218168704669 1.52218168704669 1 8.92475716518777 144 406 940 494 4206 127 119 494 1402 1226 179 256 M14209 GO_NEGATIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_T_CELL_SELECTION.html The process of elimination of immature T cells which react strongly with self-antigens. 7/20 Gene Ontology BP GO:0043383 0.0030092839903515 0.0174869906973742 500 1358.72727272727 496 0.000301336687955832 131 1.86280643978199 1.86280643978199 1 12.4255935702301 496 3552 4204 2600 1511 347 131 180 252 1417 256 257 M11624 GO_RESPONSE_TO_MURAMYL_DIPEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MURAMYL_DIPEPTIDE.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. 12/24 Gene Ontology BP GO:0032495 0.00126212382139426 0.00921709920957392 500 849.636363636364 497 0.000114804406785037 84 1.00801544033991 1.06710845596515 1 7.78799044537882 497 420 979 473 106 437 84 1168 2478 1861 843 258 M13066 GO_MIDDLE_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDDLE_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). 9/30 Gene Ontology BP GO:0042474 0.00702173455372421 0.0314994333651609 555 852.090909090909 498 0.000704402086745168 111 1.26983397241308 1.26983397241308 1 7.23829969598033 554 141 4006 731 327 498 210 814 111 1601 380 259 M10649 GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. 52/130 Gene Ontology BP GO:2000106 0.00504975120728542 0.0252817593649443 420 1401 499 0.000460125408639148 238 1.58826150919098 1.58826150919098 1 9.62911914740333 419 3707 499 3393 3351 238 467 428 1606 1019 284 260 M10496 GO_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. 361/931 Gene Ontology BP GO:0043408 0.000247277511720674 0.00282090783026804 230 690.909090909091 502 2.24823008916067e-05 229 1.48207130044611 1.450997840291 1 14.3433392456023 229 1564 296 690 1831 358 502 264 954 610 302 261 M13880 GO_RETINAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. 6/26 Gene Ontology BP GO:0042574 0.00242852216232172 0.0149742741031338 720 1021.81818181818 502 0.000243118022545611 71 1.02401096892853 1.02401096892853 1 7.09238685126465 718 307 4151 1027 2252 502 71 392 186 1329 305 262 M14580 GO_REGULATION_OF_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_FUSION.html Any process that modulates the frequency, rate or extent of myoblast fusion. 6/24 Gene Ontology BP GO:1901739 0.00253349087266703 0.015498021240834 235 1042.36363636364 505 0.000253638387489735 76 1.42043394401061 1.42043394401061 1 9.75754490499839 234 1815 4252 855 359 393 76 578 1924 505 475 263 M15711 GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. 9/18 Gene Ontology BP GO:0060055 0.00023339446143437 0.00272959819758131 60 1089.81818181818 505 2.33418977896968e-05 19 1.42267534279842 1.42267534279842 1 13.8456814133653 181 1502 4445 1358 505 60 19 289 1947 1625 57 264 M13445 GO_LIVER_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIVER_REGENERATION.html The regrowth of lost or destroyed liver. 12/26 Gene Ontology BP GO:0097421 0.00193224857088197 0.0126156182485728 825 610.181818181818 508 0.000175813431314225 140 1.29570805419519 1.29570805419519 1 9.34028806472487 274 824 2063 742 140 508 672 212 249 822 206 265 M16041 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 57/140 Gene Ontology BP GO:0090100 0.00541552414160916 0.0264398302728615 500 1619.72727272727 508 0.000493536466285187 239 1.37799012161772 1.17035711219175 1 8.2525685330776 2638 239 508 266 500 3486 2408 2851 496 477 3948 266 M10968 GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 48/99 Gene Ontology BP GO:0061180 0.00109945016496701 0.00830040181453953 515 547.090909090909 511 1e-04 52 1.30969181170248 1.34118960435966 1 10.3449343255238 511 52 611 66 115 770 527 2080 286 346 654 267 M13833 GO_POSITIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEATH.html Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 414/961 Gene Ontology BP GO:0010942 0.000382142415400043 0.00395164194811224 405 540.909090909091 512 3.47462554639711e-05 80 1.36851145667966 1.4607018623654 1 12.4838814045304 403 177 320 189 563 1416 886 512 852 80 552 268 M12833 GO_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TASTE.html The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. 17/88 Gene Ontology BP GO:0050909 0.00250225790116864 0.0153677029565159 80 614.363636363636 513 0.000227737134938078 69 1.5083998834654 1.60980625464797 1 10.3828167104368 77 727 513 521 1928 140 69 1044 1278 258 203 269 M10963 GO_POSITIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LOCOMOTION.html Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. 278/658 Gene Ontology BP GO:0040017 9.84834327855796e-11 1.22929819469233e-08 105 523.545454545455 514 8.95303934454437e-12 37 1.3998067084656 1.41689259621835 1 42.0310852317842 102 686 37 678 1111 728 402 173 931 397 514 270 M13232 GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. 29/68 Gene Ontology BP GO:0033628 0.00109945016496701 0.00830040181453953 350 470.272727272727 514 1e-04 73 1.47677254343684 1.47677254343684 1 11.6646640370772 347 264 636 73 829 805 279 625 211 514 590 271 M16796 GO_SPLEEN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLEEN_DEVELOPMENT.html The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. 19/48 Gene Ontology BP GO:0048536 0.00205323158679319 0.0132404920242788 230 912.181818181818 514 0.000186831849894737 116 2.05369581223184 2.05369581223184 1 14.6406752544272 514 2565 1252 1821 1742 228 228 146 297 1125 116 272 M10805 GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION.html Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 13/28 Gene Ontology BP GO:0010544 0.00193731118053681 0.0126156182485728 105 957.818181818182 516 0.00017627447956046 105 1.66304601929138 1.66304601929138 1 11.9882938404584 105 1393 421 1600 2362 326 171 334 1382 1926 516 273 M12479 GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. 22/76 Gene Ontology BP GO:0032651 8.83072816651502e-05 0.00130162129768664 595 535.181818181818 517 8.02825695361886e-06 21 1.45840660559568 1.45840660559568 1 15.9738368098206 591 532 833 440 853 313 517 21 1350 355 82 274 M16627 GO_NEPHRIC_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_MORPHOGENESIS.html The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. 14/25 Gene Ontology BP GO:0072178 0.00491842842710867 0.0247950740359018 570 586.181818181818 517 0.00044813262252684 200 1.41327141679078 1.41327141679078 1 8.6134973070127 566 416 772 299 255 1503 892 721 307 200 517 275 M15828 GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. 80/235 Gene Ontology BP GO:0060041 3.42347143957681e-05 0.000622658752658488 515 872.727272727273 518 3.11229519470634e-06 77 1.56617863337203 1.71636091281756 1 19.0580369060846 513 1425 218 1129 1297 2024 518 301 492 77 1606 276 M10624 GO_RESPONSE_TO_STEROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 274/831 Gene Ontology BP GO:0048545 8.57084456165618e-16 5.48149290924023e-13 10 596.545454545455 519 7.7916768742329e-17 6 1.40708979154971 1.46479940919639 1 65.4875161127137 412 472 6 6 935 1275 519 1381 729 52 775 277 M14085 GO_RESPONSE_TO_AMINO_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINO_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 78/177 Gene Ontology BP GO:0043200 0.000500855515006989 0.00490605940121825 330 540.363636363636 519 4.55426888118137e-05 146 1.29982054668245 1.33554093181915 1 11.3937009251094 328 219 332 146 928 1270 372 526 624 519 680 278 M16165 GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. 20/59 Gene Ontology BP GO:0046622 0.000713681149520345 0.00652287712051764 1240 1142.36363636364 519 6.49011612053989e-05 43 1.49067708129077 1.59516475594418 1 12.3666963863622 1237 99 519 43 73 3104 1680 3669 292 161 1689 279 M13025 GO_CELL_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGGREGATION.html The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. 17/45 Gene Ontology BP GO:0098743 5.88278297640799e-05 0.000947401927441362 425 613.454545454545 520 5.34812753405335e-06 106 1.39047436038058 1.39061895307153 1 15.9578826637228 425 106 234 551 520 1588 315 883 1324 112 690 280 M16745 GO_CARTILAGE_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_CONDENSATION.html The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. 17/45 Gene Ontology BP GO:0001502 5.88278297640799e-05 0.000947401927441362 430 614.454545454545 521 5.34812753405335e-06 107 1.39047436038058 1.39061895307153 1 15.9578826637228 426 107 235 552 521 1589 316 884 1325 113 691 281 M11815 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. 70/161 Gene Ontology BP GO:0097202 0.000829637225319109 0.00713663895475481 425 591.818181818182 523 7.54500230262243e-05 40 1.42927129665762 1.54115026929357 1 11.6453907465053 424 40 915 92 528 2126 523 85 737 661 379 282 M14501 GO_CELLULAR_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. 80/207 Gene Ontology BP GO:0009267 0.000335387890730835 0.00361300690641129 625 793.454545454545 523 3.04944573825815e-05 53 1.31035707779818 1.38353550154175 1 12.1469119519733 624 2004 523 1093 53 318 445 708 2442 360 158 283 M15140 GO_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHRONIC_INFLAMMATORY_RESPONSE.html Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. 12/23 Gene Ontology BP GO:0002544 0.000106208267053187 0.00152199069113564 145 761 523 9.6557631601428e-06 27 1.29064118907003 1.29064118907003 1 13.8035324820354 145 735 1031 1356 2482 91 51 27 523 1885 45 284 M16055 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 23/54 Gene Ontology BP GO:0060999 0.0114161070061961 0.0446545786265953 130 849.909090909091 523 0.0010432527953384 127 1.71174815221355 1.71174815221355 1 8.77251206780883 127 1534 1443 1294 427 467 310 523 1684 1297 243 285 M10631 GO_CARDIAC_CHAMBER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_MORPHOGENESIS.html The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. 74/183 Gene Ontology BP GO:0003206 2.38758749376354e-08 1.43968425110962e-06 300 547.272727272727 524 2.17053410879566e-09 58 1.65093625062317 1.52005677396224 1 36.608271131721 300 222 77 276 581 1165 524 1307 571 58 939 286 M14576 GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of adherens junction organization. 20/47 Gene Ontology BP GO:1903393 0.000142459576274134 0.00187909037682047 175 657.454545454545 526 1.29517092716529e-05 160 1.40117059287068 1.40357105595644 1 14.4988125044926 171 407 272 512 1395 797 526 925 1386 160 681 287 M10721 GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase C activity. 17/64 Gene Ontology BP GO:1900274 0.000359186692791728 0.00379886973720272 400 536.636363636364 529 3.26586681288924e-05 55 1.73198783511034 1.73198783511034 1 15.9121715098467 397 961 556 671 55 505 357 920 256 529 696 288 M11608 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. 17/45 Gene Ontology BP GO:0060043 0.00641751229338585 0.0297370355071762 685 957.818181818182 529 0.000585119028533098 221 1.46445863131043 1.59503604752152 1 8.48669720016866 685 648 529 221 403 1480 384 4283 511 257 1135 289 M11897 GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of astrocyte differentiation. 20/50 Gene Ontology BP GO:0048710 0.00837890785086045 0.036121884077572 175 960.909090909091 529 0.000764635537439176 100 1.08159950693028 1.08159950693028 1 5.9211780155547 172 100 1212 646 4412 267 206 529 588 2286 152 290 M12120 GO_RESPONSE_TO_XENOBIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_XENOBIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. 42/205 Gene Ontology BP GO:0009410 4.32897154151459e-05 0.000744422772861194 2235 1567.18181818182 530 3.93550611423174e-06 156 1.59513216774341 1.72130271600545 1 18.9406852794752 2232 248 223 172 156 3306 2471 4519 530 286 3096 291 M11315 GO_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGENERATION.html The regrowth of a lost or destroyed body part, such as an organ or tissue. 104/245 Gene Ontology BP GO:0031099 0.00725136726582682 0.0323731713608018 310 674.818181818182 542 0.00066139810910959 207 1.25825831561432 1.25825831561432 1 7.11556370449374 308 207 542 321 999 1933 971 364 638 859 281 292 M11096 GO_ALDEHYDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. 10/18 Gene Ontology BP GO:0046185 0.0131685682760175 0.0497227481741481 135 1112.72727272727 543 0.00120436895228571 132 0.433562253433551 -0.433562253433551 -1 2.1451188786926 132 428 2837 1430 543 134 179 932 2028 3165 432 293 M15691 GO_POSITIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_STORAGE.html Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 13/29 Gene Ontology BP GO:0010884 0.0241402299230624 0.0749056652950379 160 690.181818181818 543 0.00221902350920075 157 1.39074769531634 1.39074769531634 1 5.94149068076858 157 1038 774 812 914 411 321 543 1679 409 534 294 M16492 GO_ISOPRENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 46/195 Gene Ontology BP GO:0006720 0.000463689773259712 0.00460023849838641 340 876.363636363636 545 4.21625030100086e-05 64 1.39686300240301 1.59707913987393 1 12.3925470104966 336 1927 576 1234 3360 829 181 64 391 545 197 295 M15460 GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 5/21 Gene Ontology BP GO:0035413 0.000999550119979004 0.00804317366908581 980 944.545454545455 547 1e-04 1 1.78457394454291 1.78457394454291 1 14.1885229625296 978 842 4411 81 476 1315 1017 547 1 443 279 296 M16413 GO_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized. 93/279 Gene Ontology BP GO:0048705 0.000692433293948177 0.00636627283921067 550 773.818181818182 547 6.2968302559077e-05 135 1.51657732782638 1.52714615540143 1 12.6423211860827 547 363 348 284 731 2709 1018 517 593 135 1267 297 M13050 GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 35/104 Gene Ontology BP GO:0010517 0.00282866913850886 0.0166813250037299 550 659 548 0.000257482971341825 231 1.6411551960705 1.79792962869092 1 11.0747090004059 548 946 454 599 231 919 324 1438 275 365 1150 298 M15217 GO_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. 194/509 Gene Ontology BP GO:0035239 2.35815470941562e-05 0.000480215452448101 290 722.545454545455 549 2.1437999878038e-06 91 1.52094193141274 1.5514676789236 1 19.158876806288 288 483 198 228 1147 2037 1341 658 549 91 928 299 M14879 GO_CELLULAR_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 80/199 Gene Ontology BP GO:0097306 2.755621571941e-08 1.64030140493873e-06 465 857 550 2.50511055132426e-09 78 1.61385216793821 1.77334437526615 1 35.4388871360695 462 1148 78 550 391 1793 531 355 1872 1136 1111 300 M13488 GO_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BROWN_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 17/40 Gene Ontology BP GO:0050873 0.00192060284324092 0.0125841624771701 110 928.272727272727 551 0.000174752871283997 109 0.858982002181133 0.858982002181133 1 6.19562397215893 109 551 1305 939 138 161 123 1311 1307 3752 515 301 M13538 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. 18/47 Gene Ontology BP GO:0055025 0.000387895398178456 0.00400221851942794 1065 1179.72727272727 551 3.52694370241173e-05 58 1.39003161840708 1.46935792733956 1 12.6510510729238 1062 103 551 75 58 3082 2059 3737 368 130 1752 302 M15871 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. 43/118 Gene Ontology BP GO:1900076 0.00688119353107272 0.0311701283558738 420 1079.54545454545 551 0.000627528305063427 300 1.23719315255334 1.23719315255334 1 7.07367477186754 416 1633 1349 1836 310 490 551 454 1842 2694 300 303 M11546 GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of B cell proliferation. 18/57 Gene Ontology BP GO:0030890 0.00630175901770034 0.029376573412834 645 517.818181818182 554 0.000574534793111122 278 1.3809894040836 1.3809894040836 1 8.03074841177429 692 645 763 278 289 554 645 514 363 564 389 304 M11882 GO_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 288/754 Gene Ontology BP GO:0010035 4.88250103107089e-12 1.217064218751e-09 685 652.727272727273 555 4.43863730098338e-13 17 1.52076969803207 1.5349899038485 1 51.4608264810714 423 473 17 345 1627 1070 684 684 1033 269 555 305 M11334 GO_TISSUE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. 109/311 Gene Ontology BP GO:0001894 1.72472734741539e-05 0.000374201358600452 160 771 556 1.56794624441512e-06 144 1.43264668279223 1.50405196499813 1 18.6357588452367 160 2445 191 436 1816 556 810 891 674 144 358 306 M14320 GO_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 13/38 Gene Ontology BP GO:0070741 0.000103373854874993 0.00149521747098004 30 583.363636363636 558 9.39806477611076e-06 11 1.93660894790567 1.93660894790567 1 20.7688793777737 687 116 561 11 26 667 558 1306 30 1953 502 307 M16196 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. 56/124 Gene Ontology BP GO:0033138 0.000187791439630518 0.00235017696551077 240 728.545454545455 558 1.70734064887142e-05 18 1.96629678935523 1.96629678935523 1 19.621412777885 240 1833 773 894 2630 68 101 182 558 717 18 308 M10777 GO_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MATURATION.html Any process leading to the attainment of the full functional capacity of a protein. 145/391 Gene Ontology BP GO:0051604 0.00884773112953515 0.0371972480966678 1305 1106.63636363636 563 0.000807592332477318 295 1.57628870676326 1.65616327107868 1 8.55310631325814 1302 348 1184 412 452 4604 1137 295 563 322 1554 309 M13731 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of phagocytosis. 33/79 Gene Ontology BP GO:0050766 0.00179184483391807 0.0119191053923805 180 600.181818181818 563 0.000163027810262965 178 1.5087746714315 1.5087746714315 1 11.017465010189 178 1099 417 541 1304 715 563 235 610 326 614 310 M15806 GO_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLIC_PROCESS.html The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. 21/78 Gene Ontology BP GO:0019748 3.7995702094604e-05 0.000678515557020178 485 728.818181818182 563 3.45421439324025e-06 13 2.12914031520114 2.12914031520114 1 25.6069013254607 485 274 563 251 13 1125 714 2167 193 1234 998 311 M12472 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of smooth muscle cell proliferation. 46/99 Gene Ontology BP GO:0048661 0.00938548409280415 0.0387693973691189 475 918.818181818182 566 0.000856887687689282 301 1.46086719188439 1.57864763925559 1 7.82712407646504 472 707 566 301 3578 957 379 382 522 1373 870 312 M10641 GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. 23/66 Gene Ontology BP GO:2000351 0.00276421890713019 0.0164416526426762 450 672.090909090909 568 0.000251608924365937 173 1.54370995284373 1.54370995284373 1 10.4539654426614 450 1433 1140 558 173 568 380 722 481 707 781 313 M10464 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. 31/88 Gene Ontology BP GO:0043551 0.00149934604684582 0.0104057753296041 240 771.636363636364 569 0.000136397168962401 122 1.53558297414068 1.53558297414068 1 11.5569470498318 569 260 779 237 122 1848 1233 1208 236 547 1449 314 M14328 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. 70/154 Gene Ontology BP GO:0048660 0.00081161793234111 0.00702251644296641 365 739.545454545455 569 7.38106824479262e-05 211 1.45926205643191 1.52633586415081 1 11.9285280579506 211 702 358 365 2817 493 361 613 569 970 676 315 M13446 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. 118/275 Gene Ontology BP GO:2000377 0.00163816279094399 0.0112182740978657 1390 1140.90909090909 570 0.000149034897449797 204 1.44884897334913 1.49986048123241 1 10.7246080717232 1389 204 408 418 338 3880 1918 961 570 552 1912 316 M15276 GO_SENSORY_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_MORPHOGENESIS.html Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 133/407 Gene Ontology BP GO:0090596 1.04393276631081e-06 3.53794148465773e-05 250 681.818181818182 570 9.49030237884351e-08 63 1.49847950258194 1.61339620074206 1 25.3186159674188 250 203 134 503 2347 930 893 570 634 63 973 317 M13501 GO_POSITIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_RESORPTION.html Any process that activates or increases the frequency, rate or extent of bone resorption. 4/15 Gene Ontology BP GO:0045780 0.0100940007436694 0.0408600221908083 575 1048.90909090909 572 0.00101401460015476 338 1.91509024629137 1.91509024629137 1 10.0949773616683 572 1753 4088 451 413 338 388 786 1235 1098 416 318 M14984 GO_POSITIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_REMODELING.html Any process that activates or increases the frequency, rate or extent of bone remodeling. 4/15 Gene Ontology BP GO:0046852 0.0100940007436694 0.0408600221908083 575 1071.45454545455 573 0.00101401460015476 339 1.91509024629137 1.91509024629137 1 10.0949773616683 573 1754 4330 452 414 339 389 780 1236 1102 417 319 M15210 GO_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS.html Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. 46/117 Gene Ontology BP GO:0050764 0.00038121515772687 0.00395085262795951 220 712.727272727273 577 3.46619300520651e-05 106 1.5087746714315 1.5087746714315 1 13.7638920977735 219 1366 319 825 1642 895 439 106 908 544 577 320 M15453 GO_REGULATION_OF_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_SPECIFICATION.html Any process that mediates the adoption of a specific fate by a cell. 10/24 Gene Ontology BP GO:0042659 0.00137099279814933 0.00973321033915497 505 647.909090909091 578 0.000124713447053448 114 1.48948086284786 1.53934559580888 1 11.3740425864063 938 1243 578 140 114 501 575 1146 656 732 504 321 M12727 GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 36/61 Gene Ontology BP GO:0010660 0.00218187574011958 0.0139345929317403 580 847.818181818182 579 0.00019854933183565 95 1.8062439535052 1.8062439535052 1 12.724465430144 579 1020 1084 303 3558 400 275 150 784 1078 95 322 M15102 GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 6/15 Gene Ontology BP GO:0009143 0.00933731048602691 0.0386391556030507 425 988.545454545455 579 0.000937677749527071 148 1.82051220676583 1.82051220676583 1 9.76415121863382 422 674 4353 947 1375 579 151 335 148 1334 556 323 M15883 GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 9/22 Gene Ontology BP GO:0043649 0.000834819993502659 0.00715141924323404 875 997.272727272727 579 8.35133775407617e-05 70 1.02737349164868 -0.996842208398223 -1 8.36731113558986 871 431 4472 579 89 383 2335 693 70 682 365 324 M10339 GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 160/477 Gene Ontology BP GO:0045861 0.000477232141354024 0.00471899098907953 330 858.454545454545 580 4.33941541605739e-05 212 1.35172319591195 1.42898514975275 1 11.9352871750614 988 690 330 333 212 3004 1685 326 824 580 471 325 M15129 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 3/21 Gene Ontology BP GO:0033139 0.0145440336776203 0.0530463066497965 585 1713.09090909091 582 0.00146401078389661 262 0.677933667058247 0.677933667058247 1 3.28187522475352 582 2188 4358 2592 510 262 333 560 2909 4189 361 326 M15888 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 3/21 Gene Ontology BP GO:0033141 0.0145440336776203 0.0530463066497965 585 1740.54545454545 583 0.00146401078389661 263 0.677933667058247 0.677933667058247 1 3.28187522475352 583 2189 4475 2593 511 263 334 554 2910 4372 362 327 M14244 GO_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 21/61 Gene Ontology BP GO:0009268 0.000115679290429139 0.0016209598125248 125 1280.54545454545 584 1.0516852133368e-05 28 1.5361147374397 1.5361147374397 1 16.269362687476 122 3179 584 2206 4483 300 328 28 1331 1231 294 328 M16522 GO_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. 101/270 Gene Ontology BP GO:0042594 0.000377876440354166 0.00392634179109736 590 689.909090909091 586 3.43583055259993e-05 57 1.29766234541932 1.41336336089838 1 11.8513194444338 586 1211 442 595 57 744 489 915 1859 399 292 329 M11757 GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of phospholipid metabolic process. 48/120 Gene Ontology BP GO:1903725 0.000972540284241159 0.00797792321507368 270 772.909090909091 588 8.84518613932338e-05 91 1.4474281601115 1.4474281601115 1 11.5274310466583 266 380 588 372 91 1442 1044 970 1686 584 1079 330 M13784 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell migration. 47/93 Gene Ontology BP GO:0014910 0.0180811487454565 0.0617688382408293 145 1019.54545454545 589 0.00165740772930831 143 1.59938650336367 1.70099335352435 1 7.3412459562664 143 3738 675 1715 1989 362 234 704 589 572 494 331 M11039 GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of vasculature development. 88/200 Gene Ontology BP GO:1904018 6.05374823161917e-05 0.000959302151515625 155 655.727272727273 593 5.503558926594e-06 151 1.80474710121975 1.80474710121975 1 20.675176928497 151 1630 238 699 753 558 473 593 759 936 423 332 M12885 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. 33/92 Gene Ontology BP GO:1903727 0.000208923888876243 0.00251743375002141 490 802.090909090909 593 1.89948847323632e-05 38 1.35507479481972 1.35507479481972 1 13.3685340812386 486 522 514 380 38 1089 1172 1195 1941 593 893 333 M15575 GO_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. 28/74 Gene Ontology BP GO:0060350 0.000224322369118181 0.00266375641896602 375 687.272727272727 593 2.03950223045348e-05 267 1.46206360224132 1.47652604330442 1 14.2878643732855 374 629 288 737 587 1438 642 308 1697 267 593 334 M11666 GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS.html The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 11/36 Gene Ontology BP GO:0003203 5.97381755967106e-05 0.000953142093799062 3085 1532.63636363636 594 5.43089070653122e-06 18 1.2668161936589 -1.23123888980148 -1 14.5260956172756 3083 297 594 467 18 2233 938 4313 283 332 4301 335 M13801 GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 264/821 Gene Ontology BP GO:0000904 8.97104181180616e-08 4.62806079246845e-06 235 648.272727272727 594 8.15549288874774e-09 41 1.45272781995725 1.51825998096969 1 29.4166641407105 235 477 90 137 2341 918 770 594 845 41 683 336 M14932 GO_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_DEVELOPMENT.html The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. 97/268 Gene Ontology BP GO:0060485 1.2132323034683e-11 2.25321503400132e-09 595 799.272727272727 595 1.10293845770453e-12 25 1.51389885291994 1.63163290652615 1 49.6911974264602 595 211 25 27 1670 1997 979 1470 524 31 1263 337 M10820 GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 208/544 Gene Ontology BP GO:0010769 5.35043887108843e-06 0.000137249103195931 440 856.727272727273 596 4.86404716681328e-07 133 1.45344097860876 1.48497908657297 1 21.3094408523722 438 596 169 536 1882 2008 1549 516 649 133 948 338 M10645 GO_STEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. 27/94 Gene Ontology BP GO:0055092 0.00793733370059546 0.0346092586912415 190 1106.45454545455 600 0.00072419237509689 137 1.8033407415599 1.8033407415599 1 9.99949518990696 190 2623 929 1768 425 600 137 553 2940 1470 536 339 M13144 GO_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. 27/94 Gene Ontology BP GO:0042632 0.00793733370059546 0.0346092586912415 195 1103.63636363636 601 0.00072419237509689 138 1.8033407415599 1.8033407415599 1 9.99949518990696 191 2624 930 1769 426 601 138 509 2941 1474 537 340 M13211 GO_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 43/128 Gene Ontology BP GO:0060191 0.0102304706889801 0.0413403615395427 880 899.636363636364 601 0.000934396055426561 250 1.6411551960705 1.79792962869092 1 8.61936977688714 878 250 575 601 458 1586 693 2298 334 492 1731 341 M14038 GO_RESPONSE_TO_NICOTINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NICOTINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. 28/72 Gene Ontology BP GO:0035094 0.00013738883600915 0.00184702166916731 195 951.727272727273 602 1.2490674238134e-05 30 1.42926438603427 1.42926438603427 1 14.8300744609464 193 267 1344 799 4311 450 602 30 703 1549 221 342 M14540 GO_RESPONSE_TO_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 294/708 Gene Ontology BP GO:0070848 1.40196589284506e-06 4.49727756002574e-05 465 525.545454545455 603 1.27451526023523e-07 14 1.4647082252439 1.50303024678389 1 24.1686847962075 465 685 138 131 290 1311 742 603 626 14 776 343 M10614 GO_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 202/549 Gene Ontology BP GO:0001101 8.58883573613556e-11 1.13937040922507e-08 180 480.636363636364 604 7.80803248770082e-12 3 1.40244724086444 1.45116953510652 1 42.2860039166471 176 3 35 117 643 1276 604 730 863 71 769 344 M14037 GO_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 491/1440 Gene Ontology BP GO:0033993 8.14016175476926e-20 1.88973855136968e-16 370 655.272727272727 605 7.4001470497902e-21 2 1.4187312348213 1.45927843158212 1 84.675798512651 370 334 2 16 1524 1747 605 726 1072 42 770 345 M14490 GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 14/45 Gene Ontology BP GO:0035412 0.000776378774467645 0.00686614599972053 555 781.636363636364 606 7.06048085041169e-05 44 1.78457394454291 1.78457394454291 1 14.6539907326118 552 2027 1491 1367 285 606 824 163 320 919 44 346 M12127 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an external stimulus. 156/449 Gene Ontology BP GO:0032103 5.8280229691565e-05 0.000946136735866911 240 522.090909090909 607 5.29834305919801e-06 15 1.34215110686644 1.36732294289979 1 15.4062539275144 236 15 233 607 559 767 753 377 817 739 640 347 M16086 GO_BASEMENT_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. 19/31 Gene Ontology BP GO:0071711 2.93604084650969e-05 0.000564283240835162 45 615.636363636364 608 2.66916366416963e-06 44 1.46778240338295 1.46778240338295 1 18.0988991363314 44 405 207 813 1083 640 463 608 1281 599 629 348 M11811 GO_FOREBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 187/610 Gene Ontology BP GO:0030900 2.41797990780316e-07 1.06920768685048e-05 760 764.272727272727 609 2.19816379414452e-08 17 1.36994993766445 1.48782071460311 1 25.8493881646157 758 484 103 291 411 1894 1359 688 1793 17 609 349 M11324 GO_PITUITARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PITUITARY_GLAND_DEVELOPMENT.html The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. 17/63 Gene Ontology BP GO:0021983 0.00421681644287234 0.0222991785242099 3740 1817.36363636364 610 0.00038408370155145 153 1.41492070465498 -1.38945983718384 -1 8.87101736762759 3739 279 610 153 230 3571 3789 4566 495 530 2029 350 M15173 GO_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. 74/169 Gene Ontology BP GO:0001952 2.28246880443064e-05 0.000471000118176509 1010 666 611 2.07499316824072e-06 116 1.44233073207322 1.44764697753635 1 18.2147051620535 163 1007 196 510 1006 1548 860 455 611 116 854 351 M13677 GO_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. 311/798 Gene Ontology BP GO:0035295 9.22881036956794e-11 1.19026018183066e-08 615 834.545454545455 613 8.38982760905005e-12 10 1.4619565433187 1.54129917544947 1 43.9749938278452 613 338 36 32 1221 2563 1493 860 599 10 1415 352 M13904 GO_METANEPHRIC_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 17/42 Gene Ontology BP GO:0072210 0.00109945016496701 0.00830040181453953 550 882.909090909091 613 1e-04 35 1.55090525503358 1.85748458485995 1 12.2502201396672 1328 547 613 35 546 1512 1182 1674 68 259 1948 353 M11625 GO_REGULATION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSITIVE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 16/34 Gene Ontology BP GO:0050926 0.00843634822839025 0.0362020544295597 440 817.818181818182 615 0.000769897625065892 112 1.9083122944764 1.9083122944764 1 10.4400134189555 439 112 1860 838 607 615 141 1006 302 2105 971 354 M12958 GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA.html Any process of the innate immune response that takes place in the mucosal tissues. 16/97 Gene Ontology BP GO:0002227 0.00393947216982501 0.0212685689354622 75 599 615 0.000358776745151392 72 1.20074158169684 -1.20074158169684 -1 7.62186114905088 72 959 615 802 757 84 106 582 1265 1006 341 355 M14241 GO_RESPONSE_TO_BMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 44/151 Gene Ontology BP GO:0071772 2.7694312223013e-05 0.000547168900644466 615 707.454545454545 615 2.5176964412841e-06 43 1.52253264247638 1.45485176797806 1 18.8513143894891 615 942 204 859 296 1688 727 611 443 43 1354 356 M16092 GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 20/47 Gene Ontology BP GO:0009069 0.000372634764159006 0.00390551514670488 135 900.363636363636 616 3.38816268906384e-05 14 1.59008010255122 -1.59008010255122 -1 14.5358598917041 131 1167 2493 1623 616 14 22 70 1423 2308 37 357 M11100 GO_HYALURONAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 8/19 Gene Ontology BP GO:0030214 6.9342813594947e-06 0.00017034850979965 1110 1061.72727272727 617 6.93430299750582e-07 2 2.1897291610845 2.1897291610845 1 31.324545810191 1110 2139 3689 113 9 1640 2269 2 69 617 22 358 M11945 GO_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_FORMATION.html The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 8/26 Gene Ontology BP GO:0003272 7.78700512481742e-05 0.00117768940698786 1685 1065.72727272727 618 7.78727800679508e-06 22 1.33151279731948 1.30239349751632 1 14.8036014872752 1684 146 3831 465 22 643 241 1869 248 618 1956 359 M14157 GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 334/883 Gene Ontology BP GO:0071345 0.00019820163641364 0.0024281803151639 545 859.636363636364 619 1.8019954089017e-05 283 1.46715711119265 1.54631686273116 1 14.5615929817998 545 1414 283 1396 711 1970 561 350 1024 583 619 360 M12865 GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 126/317 Gene Ontology BP GO:0090092 0.000397506179813912 0.00408323272760176 1545 1123.45454545455 620 3.61434564766702e-05 138 1.30701631932299 1.32743229563355 1 11.852327398644 1545 489 322 138 483 3191 1787 1108 620 316 2359 361 M11433 GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. 34/79 Gene Ontology BP GO:0032922 0.00113619946294973 0.00846769519498488 285 746.272727272727 621 0.000103344243879495 102 0.955340148049993 1.03233133659859 1 7.51457147506598 281 621 1385 858 102 312 530 834 2361 630 295 362 M12864 GO_BONE_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MINERALIZATION.html The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. 16/53 Gene Ontology BP GO:0030282 0.00589774219562684 0.0281332505413043 245 1085.72727272727 622 0.000537601128168031 242 1.98051087380316 1.98051087380316 1 11.6582852645023 242 3250 662 1433 2975 570 481 244 459 1005 622 363 M16002 GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rho protein signal transduction. 57/144 Gene Ontology BP GO:0035023 6.99951914583067e-05 0.0010796932689067 625 502.818181818182 622 6.36340168402235e-06 36 1.32744123730801 1.43389279502759 1 14.9484481713277 63 234 244 36 1213 758 622 702 625 179 855 364 M16163 GO_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 223/596 Gene Ontology BP GO:0048568 1.06014625658607e-10 1.26211771008439e-08 470 732.727272727273 623 9.63769324215599e-12 39 1.49642155345437 1.51852010875877 1 44.867080330912 466 185 39 199 985 1974 1559 647 623 53 1330 365 M10469 GO_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_PRESSURE.html Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 89/298 Gene Ontology BP GO:0008217 8.77063672406503e-08 4.57551306852067e-06 65 781.363636363636 624 7.97330643065444e-09 65 1.32137783476633 1.35210987168408 1 26.7817983561479 65 698 89 1496 1188 392 507 1548 1532 456 624 366 M14468 GO_RESPONSE_TO_VITAMIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. 20/35 Gene Ontology BP GO:0033197 0.000219423628121208 0.00261226642401735 255 671 624 1.99495923685616e-05 254 1.46778240338295 1.46778240338295 1 14.3909802445136 254 533 287 624 495 835 376 1235 1361 634 747 367 M16310 GO_ALKALOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). 7/31 Gene Ontology BP GO:0009820 1.11549302090634e-06 3.69945292576296e-05 1005 1008 625 1.11549358085284e-07 1 1.5518043504212 1.5518043504212 1 26.1054072928795 1004 142 4545 305 1 1037 1263 1570 35 561 625 368 M16725 GO_NEGATIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a lower concentration of a chemical. 30/67 Gene Ontology BP GO:0050919 0.0153783050236204 0.0549976002302199 535 895 625 0.00140789685438265 261 1.32998205138495 1.32998205138495 1 6.35923772611041 534 261 625 685 3127 1047 479 1543 781 296 467 369 M11994 GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of an acute inflammatory response. 27/97 Gene Ontology BP GO:0002673 0.00176770158195471 0.0117945758525033 545 823.181818181818 626 0.0001608294119324 110 1.1099059725563 1.1099059725563 1 8.12403902386252 110 1588 416 1068 1156 543 543 349 1184 1472 626 370 M11157 GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. 78/206 Gene Ontology BP GO:1901136 0.00498993035110741 0.0250738599785625 3865 1686.54545454545 627 0.00045466221203418 107 1.53256469868496 1.81588458879889 1 9.31230890611071 3865 503 627 107 259 2785 4473 1109 414 336 4074 371 M12556 GO_MESENCHYMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. 69/195 Gene Ontology BP GO:0048762 2.9629192435299e-08 1.74137139844422e-06 580 778.818181818182 627 2.69356298493994e-09 56 1.41900072255868 1.49532758721956 1 31.0202372647695 576 505 79 56 2386 1332 651 1204 627 87 1064 372 M14048 GO_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. 280/697 Gene Ontology BP GO:0001944 1.57164333937936e-13 7.29714002473839e-11 90 714 627 1.42876667216316e-14 10 1.46842022016845 1.5318117984299 1 56.5015669796267 86 341 10 528 1374 1267 627 1333 928 85 1275 373 M10056 GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 283/699 Gene Ontology BP GO:0033674 0.0157877243235662 0.0560844713345968 450 699.818181818182 628 0.00144565202621549 217 1.43608981934346 1.43608981934346 1 6.82025751567342 217 992 628 448 1943 529 447 644 900 692 258 374 M10752 GO_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 29/52 Gene Ontology BP GO:0034405 0.00162391661870171 0.0111371415962069 205 556.272727272727 628 0.000147737867551211 126 1.59149792279258 1.59149792279258 1 11.7995613157722 205 716 524 639 771 739 298 126 628 897 576 375 M15778 GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 44/151 Gene Ontology BP GO:0071773 2.7694312223013e-05 0.000547168900644466 620 709.909090909091 628 2.5176964412841e-06 44 1.52253264247638 1.45485176797806 1 18.8513143894891 616 943 205 860 297 1689 728 628 444 44 1355 376 M13662 GO_NEGATIVE_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANOIKIS.html Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. 21/35 Gene Ontology BP GO:2000811 0.0369410430159999 0.0989142230238107 365 1071.18181818182 629 0.00341602903774894 354 1.67658560888596 1.67658560888596 1 6.39421449197934 365 1439 1682 1143 3385 452 629 624 482 1228 354 377 M15920 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT.html Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. 11/25 Gene Ontology BP GO:0061311 0.00960467204930819 0.0392903016078748 830 918.727272727273 633 0.000876987439595324 146 1.35687647820996 1.35687647820996 1 7.24010245653666 830 425 722 507 3450 633 146 1825 525 778 265 378 M11226 GO_MORPHOGENESIS_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIUM.html The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. 242/611 Gene Ontology BP GO:0002009 1.36645523867442e-07 6.67837018227929e-06 325 814.454545454545 634 1.24223211231559e-08 95 1.37082126715771 1.39777239973129 1 26.9293624101176 324 343 95 352 1760 1983 1566 634 819 182 901 379 M10768 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 27/104 Gene Ontology BP GO:0035725 0.0030751432628807 0.0178028555730113 635 975.090909090909 635 0.000279950009563501 123 1.40424539807361 1.53526366079789 1 9.32538459353646 468 635 1013 403 3874 1095 843 1353 285 123 634 380 M11191 GO_POSITIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_GROWTH.html Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 16/45 Gene Ontology BP GO:0060421 0.00109945016496701 0.00830040181453953 1520 1160.81818181818 635 1e-04 80 1.46445863131043 1.59503604752152 1 11.5673994660523 1516 115 635 80 191 2668 1270 3349 354 241 2350 381 M10421 GO_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a gland are generated and organized. 69/166 Gene Ontology BP GO:0022612 0.00109945016496701 0.00830040181453953 640 674.727272727273 636 1e-04 93 1.32608468337358 1.35779713447826 1 10.4744175973378 636 227 518 93 815 898 793 1461 564 417 1000 382 M16301 GO_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that modulates the frequency, rate or extent of neutrophil migration. 15/60 Gene Ontology BP GO:1902622 0.00423731267475038 0.022305944159712 665 650.545454545455 636 0.000385954184607833 113 1.17908526180776 1.17908526180776 1 7.39182874351867 661 113 934 342 234 1086 1547 636 239 966 398 383 M13726 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. 27/48 Gene Ontology BP GO:0008625 0.000102362194624029 0.00148521146762302 640 709.909090909091 637 9.30608706092302e-06 25 1.88024535692857 1.88024535692857 1 20.1852285666641 637 631 1749 487 641 1611 718 25 154 835 321 384 M16582 GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 642/1720 Gene Ontology BP GO:0010648 0.0021449347254161 0.0137364578346303 365 998.818181818182 637 0.00021470078775012 107 1.30328784274078 1.37847754564324 1 9.21205373398762 363 754 4586 543 637 1142 954 304 1119 107 478 385 M12221 GO_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_EXTRAVASATION.html The migration of a leukocyte from the blood vessels into the surrounding tissue. 20/37 Gene Ontology BP GO:0045123 0.00336620885923619 0.0190369156314661 540 1370.27272727273 638 0.00030648823079623 87 1.90344875425053 1.90344875425053 1 12.4302171595917 537 2925 572 1781 4528 638 87 321 2091 1146 447 386 M13604 GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. 7/20 Gene Ontology BP GO:0060766 0.0248104242589395 0.076187036927418 605 1071.54545454545 638 0.00250918574028996 171 1.70820157422404 1.70820157422404 1 7.24993885668441 605 441 4103 638 947 171 317 1503 1249 1413 400 387 M12716 GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 20/81 Gene Ontology BP GO:0070098 0.000478708756376579 0.00471899098907953 95 699.727272727273 639 4.35284502453105e-05 93 1.42395430722107 1.42395430722107 1 12.5730649827281 93 1783 331 768 409 497 209 909 912 1147 639 388 M10039 GO_CARDIAC_CHAMBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_DEVELOPMENT.html The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. 99/257 Gene Ontology BP GO:0003205 9.60801097251657e-06 0.000229948427553579 410 753.090909090909 643 8.73459357602303e-07 170 1.65093625062317 1.52005677396224 1 22.8004985794057 406 360 178 629 803 1554 643 1540 698 170 1303 389 M15526 GO_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_DEVELOPMENT.html The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 78/190 Gene Ontology BP GO:0001890 0.000152111699232641 0.0019838612908347 650 762.363636363636 646 1.38292925008603e-05 35 1.32502788574067 1.32502788574067 1 13.5923996530537 646 35 274 118 523 1102 1100 2442 711 520 915 390 M11084 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. 9/25 Gene Ontology BP GO:0034143 0.0151078623193287 0.0544610285315552 485 1003.63636363636 648 0.00152115673636092 287 1.48034281358945 1.48034281358945 1 7.10210535583855 483 974 3686 734 530 287 301 511 1298 1588 648 391 M12332 GO_CARDIAC_ATRIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_ATRIUM_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. 18/55 Gene Ontology BP GO:0003230 0.00337128009394771 0.0190424008226268 1205 1025.90909090909 648 0.000306950668564107 410 1.6787994770297 1.6787994770297 1 10.9623778398433 1203 410 461 483 3213 1374 899 648 594 566 1434 392 M15864 GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of stem cell proliferation. 32/102 Gene Ontology BP GO:2000648 0.00109945016496701 0.00830040181453953 2350 1104.27272727273 648 1e-04 72 1.447668659117 -1.23123888980148 -1 11.4347795946296 2349 72 1082 86 648 639 2637 2311 470 577 1276 393 M13064 GO_PREPULSE_INHIBITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREPULSE_INHIBITION.html The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. 4/22 Gene Ontology BP GO:0060134 0.00228659434610047 0.0144041588868996 670 1402 649 0.000228895059024039 75 1.51935086267539 -1.51935086267539 -1 10.6203757864386 668 452 4004 216 649 214 194 4334 3520 1096 75 394 M14600 GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS.html Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. 26/64 Gene Ontology BP GO:0097006 0.00491176972330542 0.0247950740359018 785 780.090909090909 649 0.000447524568257563 220 1.45792527800549 1.8033407415599 1 8.88565020613656 783 528 1141 416 303 1423 362 220 1305 1451 649 395 M13549 GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. 20/70 Gene Ontology BP GO:0071622 0.00509169085427905 0.0253630798097571 455 634.363636363636 650 0.000463955764868918 209 1.17908526180776 1.17908526180776 1 7.14217293332263 454 723 718 424 1192 873 650 224 361 1150 209 396 M16813 GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS.html The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. 136/356 Gene Ontology BP GO:0045137 0.00287363174078016 0.0168180897264408 3760 1947.09090909091 650 0.000261581104193568 177 1.59963029474098 1.76797011866535 1 10.772962259086 3758 202 650 468 177 3047 3275 4375 591 541 4334 397 M11696 GO_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that modulates the frequency, rate, or extent of leukocyte migration. 73/208 Gene Ontology BP GO:0002685 1.86783865631778e-07 8.67237488128344e-06 315 787.818181818182 653 1.69803528627325e-08 98 1.22213220016527 1.31556228890853 1 23.4820341427447 312 1085 98 1162 1797 653 460 314 1116 1025 644 398 M16862 GO_ACUTE_PHASE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_PHASE_RESPONSE.html An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. 24/111 Gene Ontology BP GO:0006953 0.00449004508240294 0.0233452176008924 305 975.363636363636 654 0.000409021383451963 94 1.7354036805309 1.7354036805309 1 10.7491772906598 302 94 485 815 2481 654 136 1321 1767 2424 250 399 M13761 GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell. 14/55 Gene Ontology BP GO:0042491 0.0312712153706571 0.0888026012024226 230 815 656 0.00288406926682025 192 1.63611132979598 1.63611132979598 1 6.53070478037422 227 1115 1008 817 2441 646 656 556 192 915 392 400 M16835 GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that modulates the frequency, rate or extent of execution phase of apoptosis. 19/35 Gene Ontology BP GO:1900117 0.0037793944041801 0.0205717798576884 1015 911.090909090909 657 0.000344172973534895 94 1.42256309632098 1.42256309632098 1 9.10801752410937 452 2782 884 1011 1011 571 657 233 1727 600 94 401 M10760 GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 822/2178 Gene Ontology BP GO:0010647 0.0142883282366347 0.0526380793457477 470 1067.72727272727 658 0.00143810386515291 218 1.37292091018933 1.44117617038437 1 6.66379156045843 467 457 3629 658 1795 1508 862 545 1100 218 506 402 M12854 GO_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 43/117 Gene Ontology BP GO:0051963 0.00868752598889408 0.0367695379821652 520 852.818181818182 660 0.000792911164674598 298 1.51757507270327 1.51721991470885 1 8.26345275868912 516 872 560 335 1508 866 660 2309 306 298 1151 403 M13795 GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 9/15 Gene Ontology BP GO:0030207 0.00140709578400026 0.0098837302951788 875 915.818181818182 660 0.000140798754214802 60 1.35827470555819 1.35827470555819 1 10.3377579038441 873 660 4133 187 1243 713 208 205 184 1608 60 404 M13018 GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. 8/28 Gene Ontology BP GO:0045672 0.00952386721370481 0.0392592104060817 530 1642.63636363636 662 0.000956493194558872 394 0.577697684255603 0.749146098584153 1 3.08326767022472 527 2980 3993 2408 394 662 515 418 1916 3625 631 405 M12844 GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that activates or increases the activity of a phosphoprotein phosphatase. 13/27 Gene Ontology BP GO:0032516 0.0186294619611076 0.0630441631817949 880 808.545454545455 665 0.00170810099729514 124 2.18771116543902 2.18771116543902 1 9.96797550323713 766 2355 984 876 567 659 365 656 124 877 665 406 M13571 GO_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_HOST.html An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 86/213 Gene Ontology BP GO:0051701 0.0104210354516145 0.0417015156251411 365 738.454545454545 666 0.000951884365757694 327 1.40396727764491 1.55340102229922 1 7.35352402721375 364 1311 666 908 893 1420 496 327 788 420 530 407 M16412 GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. 7/15 Gene Ontology BP GO:0048711 0.0244371891310874 0.075290790090591 480 1621.81818181818 666 0.00247101526392137 368 0.849254971022537 0.849254971022537 1 3.62096982186657 478 666 4561 1216 2805 413 405 510 1925 4493 368 408 M11805 GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE.html An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. 22/108 Gene Ontology BP GO:0002251 0.00213798868457198 0.0137108859978836 300 784 667 0.000194551749189019 299 1.20074158169684 -1.20074158169684 -1 8.4909124428505 299 1165 426 1153 663 340 569 732 1345 1265 667 409 M13163 GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY.html Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. 7/17 Gene Ontology BP GO:0006957 0.0257640611781299 0.0784268537777523 240 1221.90909090909 667 0.00260677321962999 192 1.37200307782393 1.37200307782393 1 5.75751256528913 238 667 4027 192 1778 566 264 1303 3013 554 839 410 M14565 GO_HAIR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hair cell. 18/64 Gene Ontology BP GO:0035315 0.019913874963505 0.0658568552552914 1490 896.909090909091 668 0.00182694986337553 226 1.63611132979598 1.63611132979598 1 7.33696903485245 342 1488 1488 1036 2174 637 668 441 226 1069 297 411 M10407 GO_RESPONSE_TO_ORGANOPHOSPHORUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANOPHOSPHORUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. 88/232 Gene Ontology BP GO:0046683 0.000685127218032329 0.00633674436917152 500 705.909090909091 670 6.2303697674854e-05 207 1.16309592550315 1.24566385727896 1 9.7045832997348 498 767 346 670 207 880 541 1405 881 653 917 412 M13807 GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. 50/130 Gene Ontology BP GO:0050728 0.00407369540180093 0.0217154624001856 1360 1204 670 0.000371023472153353 225 1.27613618394053 1.31689615146401 1 8.05669278715359 1357 241 632 402 225 3988 2220 896 670 629 1984 413 M15541 GO_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_STORAGE.html The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 18/37 Gene Ontology BP GO:0019915 0.0219979553663926 0.0702935352829737 675 860.272727272727 670 0.00202009488558149 197 1.94187078172274 1.94187078172274 1 8.49940913918926 675 642 670 197 2314 1121 1321 617 281 1071 554 414 M16832 GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 12/26 Gene Ontology BP GO:0043518 0.000107366692549325 0.00152915200462122 505 921.272727272727 670 9.76108479350667e-06 27 1.60640719314898 1.60640719314898 1 17.1682494099994 504 2681 2387 750 27 729 670 209 153 1894 130 415 M15240 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. 10/24 Gene Ontology BP GO:0061081 0.00654209905840258 0.0301638191938065 625 723.818181818182 673 0.000596512232221793 259 1.76654498878037 1.76654498878037 1 10.1958224130708 623 1047 822 696 599 673 434 259 1671 731 407 416 M12631 GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of adherens junction organization. 52/107 Gene Ontology BP GO:1903391 4.172133152525e-05 0.000725545224079102 195 821.454545454545 676 3.79292025087894e-06 65 1.36210528681237 1.35909828785354 1 16.2313873684753 195 509 222 297 1503 1881 1244 676 1417 65 1027 417 M12233 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 27/43 Gene Ontology BP GO:0010656 0.000118640825461753 0.00164924955873928 535 893.272727272727 680 1.07861112695912e-05 29 1.8062439535052 1.8062439535052 1 19.0788481559026 535 1527 745 757 4230 259 195 29 680 834 35 418 M14980 GO_VACUOLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_FUSION.html Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. 17/25 Gene Ontology BP GO:0097576 0.00042903994501267 0.00432111163707989 260 1406.63636363636 680 3.90112398584796e-05 23 0.244711200755906 -0.258220068540287 -1 2.19625548329377 256 1854 3390 2159 374 71 23 680 2250 4146 270 419 M15133 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of natural killer cell activation. 9/23 Gene Ontology BP GO:0032816 0.00135752486266413 0.00969112621539502 945 875 681 0.000135835486955322 116 1.51219857869234 1.51219857869234 1 11.5583226320711 941 134 4359 116 137 1021 145 121 1253 681 717 420 M10709 GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 128/326 Gene Ontology BP GO:0060828 0.00192903592039758 0.0126148081386 1155 1256.72727272727 682 0.000175520858631293 323 1.50669820602017 1.60950139855108 1 10.8613988265621 1152 600 420 544 682 4428 2464 438 1380 323 1393 421 M12560 GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. 145/340 Gene Ontology BP GO:0051056 0.000979654699054585 0.00800798726709584 150 692.818181818182 682 8.90992008257667e-05 16 1.35261241435289 1.45361412678334 1 10.7639240544247 146 16 374 396 1245 1116 992 1286 682 162 1206 422 M13100 GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. 57/171 Gene Ontology BP GO:0050709 0.00019609233898997 0.00242649293029994 105 843.727272727273 683 1.78281654042284e-05 23 1.21377392125334 1.21377392125334 1 12.0481456483595 23 866 683 1606 1428 101 227 101 2249 1764 233 423 M16968 GO_HEAD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_MORPHOGENESIS.html The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. 28/69 Gene Ontology BP GO:0060323 0.0112294246177718 0.0441101679359682 135 810.454545454545 686 0.00102610506904579 134 1.37571450531698 1.37571450531698 1 7.07819733664146 134 1323 841 1020 1768 443 162 686 1705 487 346 424 M13136 GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus. 13/29 Gene Ontology BP GO:2001273 0.0190269421674936 0.0639233664860151 690 1002.45454545455 689 0.00174486538357727 124 0.592570614704668 0.65908907339367 1 2.68642952102153 689 124 1670 509 726 923 296 467 1728 3656 239 425 M12303 GO_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. 173/465 Gene Ontology BP GO:0019216 0.000435997789246256 0.00438168341010902 565 741.363636363636 690 3.96440199658231e-05 148 1.23800347229803 1.25552053589929 1 11.0825324286929 562 193 327 148 690 1556 1008 923 1471 517 760 426 M14997 GO_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_RESORPTION.html Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). 16/43 Gene Ontology BP GO:0045124 0.0118262478809951 0.0457577240928837 1115 777.454545454545 692 0.0010809366600505 99 1.97167988307032 1.97167988307032 1 10.025311868047 671 1113 589 111 2180 731 692 1111 99 512 743 427 M10193 GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. 25/79 Gene Ontology BP GO:0061097 0.0130668689692076 0.0494857036085081 695 850.181818181818 693 0.00119501190930015 345 1.46122625220255 1.66030657365034 1 7.24116277012547 693 1532 1370 442 462 1658 983 561 345 421 885 428 M11013 GO_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of a tissue are generated and organized. 311/815 Gene Ontology BP GO:0048729 6.52599662034968e-11 9.18187948735865e-09 575 936.363636363636 693 5.93272420049386e-12 22 1.46651622396706 1.44587805291929 1 44.7395661219964 575 469 33 45 1748 2534 1788 983 693 22 1410 429 M11026 GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 6/16 Gene Ontology BP GO:0009070 0.0113668684581536 0.0445370213090354 695 1183.09090909091 694 0.00114254330720807 146 1.59008010255122 -1.59008010255122 -1 8.15588714714658 694 1710 3671 1594 2596 189 292 618 146 1310 194 430 M13718 GO_CARDIAC_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 82/191 Gene Ontology BP GO:0003231 4.064467766684e-06 0.000109716999073918 165 759 694 3.69497752340734e-07 162 1.63331807006945 1.48202370248384 1 24.5495277332117 510 498 162 744 838 1692 504 1428 694 163 1116 431 M12778 GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT.html The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. 241/630 Gene Ontology BP GO:0061458 5.09846809401291e-05 0.000857687947844274 1710 1443.81818181818 695 4.63507841282297e-06 180 1.46816114911413 1.54795513568653 1 17.0902376269255 1710 344 228 254 242 4079 2005 3032 695 180 3113 432 M15507 GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. 90/232 Gene Ontology BP GO:0030177 0.00313415856620104 0.0179653064479894 1355 1117.18181818182 697 0.000285330224456698 124 1.52114859653482 1.62657913279567 1 10.0789430123203 1354 697 900 501 436 4636 1904 479 374 124 884 433 M14065 GO_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 140/418 Gene Ontology BP GO:0008544 8.5402069700892e-07 3.00395310319122e-05 360 776 698 7.76382753211311e-08 129 1.31255714858407 1.34943725573873 1 22.5312600361688 358 200 129 665 2112 1263 891 1074 936 210 698 434 M10594 GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 147/347 Gene Ontology BP GO:0033673 0.0261943023961481 0.079179782568565 700 796.818181818182 700 0.00241013498172616 528 1.30883386196533 1.37758169746409 1 5.47181222145008 528 1141 698 698 1098 771 595 700 1144 863 529 435 M10894 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. 29/59 Gene Ontology BP GO:2000378 0.00308387841274919 0.0178311923666183 1540 946.272727272727 702 0.000280746343791131 182 1.80025986648007 1.80025986648007 1 11.950537706787 1540 525 690 499 182 2112 702 1445 416 1561 737 436 M13151 GO_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MORPHOGENESIS.html Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 425/1215 Gene Ontology BP GO:0009887 7.40849573147559e-17 1.1465881893747e-13 5 809.909090909091 705 6.73499611952327e-18 1 1.49662569458074 1.50316716857978 1 73.5147679670094 301 466 3 240 1668 2049 1363 885 705 1 1228 437 M10465 GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 27/64 Gene Ontology BP GO:0071364 0.00350090332923455 0.0194767500939333 710 740.545454545455 706 0.000318771529891387 184 1.4171363529209 1.4171363529209 1 9.2010578480123 706 1104 828 575 767 1444 506 184 1340 468 224 438 M14896 GO_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_DEVELOPMENT.html The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. 191/528 Gene Ontology BP GO:0001654 4.43252895265151e-06 0.000117601325298063 710 923.181818181818 707 4.02957989388498e-07 56 1.52285900421095 1.67307752311427 1 22.7150617415303 707 192 165 497 804 2572 1546 895 671 56 2050 439 M11810 GO_REGULATION_OF_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_FORMATION.html Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. 11/52 Gene Ontology BP GO:0003156 0.00342532336065758 0.0192773046830705 710 647.090909090909 708 0.000311878920335773 195 1.66409842843252 1.66409842843252 1 10.8327479443753 708 427 762 493 195 441 222 852 1252 770 996 440 M15599 GO_KIDNEY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MORPHOGENESIS.html Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 38/117 Gene Ontology BP GO:0060993 0.00101489117042358 0.00811039536020082 1210 732.363636363636 708 9.23054233358982e-05 102 1.79231536985775 1.85950655192706 1 14.2254811435919 1207 708 377 115 317 1724 885 1271 102 129 1221 441 M14268 GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY.html Any process that modulates the activity of the enzyme phospholipase A2. 12/30 Gene Ontology BP GO:0032429 0.0180536163682546 0.0617252877745258 865 919.818181818182 709 0.00165486295370479 212 1.60515358025269 1.60515358025269 1 7.36958337616078 865 294 802 616 3427 709 212 1640 232 824 497 442 M15225 GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of MAP kinase activity. 128/335 Gene Ontology BP GO:0043406 0.0109281894373637 0.0433671654339143 145 882.454545454545 709 0.000998441291904314 142 1.36096030293736 1.36096030293736 1 7.04039831359252 142 1000 1019 709 3061 146 159 536 1500 1173 262 443 M15793 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 10/22 Gene Ontology BP GO:0061003 0.00269583382074683 0.0162134150644139 150 1007.09090909091 709 0.000245376628833923 143 1.90919498657043 1.90919498657043 1 12.9730172389048 147 2133 1736 1635 709 385 143 162 1921 1717 390 444 M14762 GO_RHYTHMIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_PROCESS.html Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. 152/434 Gene Ontology BP GO:0048511 0.000127003789375994 0.00173740756774749 1045 752.818181818182 710 1.15464656154321e-05 187 1.3212191139073 1.38757611123233 1 13.8422480431731 1042 199 265 486 410 1744 1136 1008 1094 187 710 445 M15855 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. 35/82 Gene Ontology BP GO:0032233 0.0745215457349367 0.158445571591463 1080 1027.72727272727 710 0.00701567691209436 154 1.21556639001347 1.18084601252779 1 3.69182395541625 1076 710 1352 154 2493 1208 637 2087 534 366 688 446 M12614 GO_SULFUR_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 23/44 Gene Ontology BP GO:0044273 0.00144151386102696 0.0100494727578801 1285 863 711 0.000131132659695964 119 1.43355105008906 1.43355105008906 1 10.8713814324048 1282 801 1186 395 287 2239 1816 119 176 711 481 447 M15639 GO_CELLULAR_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 11/29 Gene Ontology BP GO:0071305 0.00537080722604144 0.0263044915089772 85 1072.09090909091 711 0.000489451257944695 82 2.51960658933014 2.51960658933014 1 15.1108478180215 82 1608 711 1029 4134 100 124 286 1673 1811 235 448 M11155 GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. 46/125 Gene Ontology BP GO:0044259 1.03802538130172e-06 3.53794148465773e-05 195 878.363636363636 713 9.43659882793874e-08 132 1.20810943749774 1.28962964965167 1 20.4124639955799 194 382 132 713 621 1527 664 1061 1718 1372 1278 449 M13900 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that activates, maintains or increases the rate of developmental growth. 97/260 Gene Ontology BP GO:0048639 0.0183075007098835 0.0623179807888483 1305 1325.36363636364 713 0.00167833155508446 136 1.403302958611 1.43636061620438 1 6.42073936127509 1305 214 661 136 562 3849 2318 3068 713 361 1392 450 M14131 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. 10/23 Gene Ontology BP GO:1903019 0.00672711197421801 0.0307695384735218 265 820.363636363636 714 0.000613433680129324 226 1.7510196525423 1.7510196525423 1 10.0488251915278 714 2316 1231 1198 683 617 226 261 264 727 787 451 M10316 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 27/84 Gene Ontology BP GO:0010518 0.000812210064586036 0.00702251644296641 1400 1213.81818181818 715 7.38645524150967e-05 79 1.55250524272995 1.73198783511034 1 12.6907310900126 1397 1278 686 666 79 2246 715 2928 223 467 2667 452 M12776 GO_EMBRYONIC_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_MORPHOGENESIS.html Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 152/440 Gene Ontology BP GO:0048562 4.36585709902512e-08 2.44224994105706e-06 305 804.272727272727 715 3.96896107787701e-09 70 1.54386337167377 1.57003764884024 1 32.8889493234398 304 347 83 563 1587 1824 1296 798 715 70 1260 453 M14542 GO_ICOSANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. 39/162 Gene Ontology BP GO:0006690 0.00628298814545256 0.0293185064917952 410 911.272727272727 715 0.000572818529755743 247 1.36513196089136 1.52862599404657 1 7.94298669169676 407 1223 526 715 3052 550 247 887 473 1160 784 454 M13853 GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. 9/23 Gene Ontology BP GO:0048642 0.000170342090364253 0.00217279759769568 720 1440.45454545455 716 1.70355149165589e-05 34 0.502564537494469 -0.563979786716918 -1 5.08003956389703 716 433 4145 739 3060 148 56 34 2502 3853 159 455 M16181 GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acid derivative. 39/162 Gene Ontology BP GO:1901568 0.00628298814545256 0.0293185064917952 410 909 716 0.000572818529755743 248 1.36513196089136 1.52862599404657 1 7.94298669169676 408 1224 527 716 3053 551 248 851 474 1162 785 456 M15707 GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. 27/60 Gene Ontology BP GO:0045668 0.0240535235254536 0.0748027526648901 440 973.454545454545 718 0.0022109643687672 271 1.02157563384348 1.02157563384348 1 4.36664549648997 436 718 1548 966 1747 310 455 1347 410 2500 271 457 M12995 GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of cell junction assembly. 21/50 Gene Ontology BP GO:1901890 0.000119316979233905 0.0016536977151732 230 821.909090909091 722 1.08475864436853e-05 171 1.40117059287068 1.40357105595644 1 14.7939504426287 230 722 263 645 1814 1064 699 1084 1408 171 941 458 M16052 GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Ras protein signal transduction. 98/239 Gene Ontology BP GO:0046578 0.00116703659268271 0.00865583210834798 185 671.272727272727 722 0.000106150557465015 27 1.30386237521331 1.43389279502759 1 10.2087647267424 185 27 387 123 808 891 722 1292 1416 373 1160 459 M16349 GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. 461/1347 Gene Ontology BP GO:0007417 4.45195998367602e-08 2.46076788145331e-06 2710 1539.63636363636 722 4.04723643069699e-09 7 1.41774723833108 1.54404401513854 1 30.1846407087916 2710 337 84 50 659 722 4076 3215 967 7 4109 460 M13152 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 738/1994 Gene Ontology BP GO:0051240 0.000144533362589504 0.00190104363315316 255 1136 723 1.44542763901896e-05 40 1.45780362068119 1.52695801885271 1 15.0569171486066 255 1820 4024 723 1839 1060 600 432 1080 40 623 461 M14876 GO_UROGENITAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UROGENITAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. 164/437 Gene Ontology BP GO:0001655 3.58721534830664e-11 5.88117517081013e-09 675 749.181818181818 726 3.26110486215012e-12 11 1.50822400236222 1.56384903463798 1 47.1195562542544 673 11 28 267 1067 1736 911 1514 726 227 1081 462 M10338 GO_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT.html Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 36/89 Gene Ontology BP GO:0046324 0.00901822056804877 0.0376543148358367 650 962.545454545455 727 0.000823218320958115 300 1.63096368252101 1.63096368252101 1 8.8169424337171 649 518 932 613 727 2396 798 300 1374 1909 372 463 M12997 GO_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_MORPHOGENESIS.html The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 149/374 Gene Ontology BP GO:0003007 1.24243008254539e-09 1.20179226526213e-07 1050 1296.27272727273 727 1.12948189386094e-10 48 1.49178868439089 1.42153495547585 1 39.1860366600556 1046 486 48 214 688 4057 2548 1955 727 108 2382 464 M13376 GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of cardiac muscle tissue are generated and organized. 43/112 Gene Ontology BP GO:0055008 7.95738679246293e-09 5.77283544959459e-07 820 1249.81818181818 729 7.23398801931342e-10 39 1.71855941663884 1.49958962882334 1 40.6967452028912 820 512 64 404 729 3153 2162 3166 477 39 2222 465 M15001 GO_CONVERGENT_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONVERGENT_EXTENSION.html The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. 10/25 Gene Ontology BP GO:0060026 0.0202091249633396 0.066358534091079 1540 1186.45454545455 729 0.00185428984988046 55 1.91021908880517 1.91021908880517 1 8.54227903078952 1539 566 1465 437 3787 2362 640 447 55 729 1024 466 M14873 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. 20/43 Gene Ontology BP GO:0048873 0.00803132653903968 0.034920911279822 735 1394.09090909091 732 0.000732799677284874 278 1.45977695703888 1.45977695703888 1 8.07286667852781 732 3469 1900 642 3917 1564 1425 278 313 636 459 467 M12269 GO_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION.html The movement of a leukocyte within or between different tissues and organs of the body. 130/380 Gene Ontology BP GO:0050900 7.59634330666926e-12 1.46957591553606e-09 120 732.272727272727 733 6.90576664245043e-13 24 1.59999301556249 1.60399523571841 1 53.6443647582576 120 1511 24 952 1488 975 440 701 868 243 733 468 M16923 GO_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSSIFICATION.html Any process that modulates the frequency, rate or extent of bone formation. 113/250 Gene Ontology BP GO:0030278 0.000791308808415779 0.00695133982527408 575 841.818181818182 734 7.19630522165553e-05 222 1.53235511913658 1.55833607949163 1 12.5517507101001 571 1310 354 222 2131 908 1395 857 439 339 734 469 M14232 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. 515/1312 Gene Ontology BP GO:1902533 0.00634933433251202 0.0295686653017586 280 1094.63636363636 735 0.000636754894160247 268 1.37612545257146 1.42084563527311 1 7.98767781133301 280 989 4210 635 2018 1007 735 268 1117 460 322 470 M12172 GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. 40/92 Gene Ontology BP GO:0001954 0.000257697616612567 0.00289007254572983 215 727.636363636364 736 2.34298006405584e-05 213 1.38870965715173 1.3886332204367 1 13.3843411124248 213 1222 302 977 936 682 370 914 1391 261 736 471 M11108 GO_NEGATIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LOCOMOTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. 165/444 Gene Ontology BP GO:0040013 2.37355599553848e-10 2.47519189670026e-08 130 787.636363636364 738 2.15777817799506e-11 44 1.41430142962921 1.47685920800086 1 40.8345585380716 126 1762 44 1321 1563 825 400 738 1020 238 627 472 M16589 GO_ZYMOGEN_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_ACTIVATION.html The proteolytic processing of an inactive enzyme to an active form. 75/192 Gene Ontology BP GO:0031638 0.00109945016496701 0.00830040181453953 770 829.454545454545 738 1e-04 36 1.42927129665762 1.54115026929357 1 11.2894633418227 767 36 972 89 597 3329 977 196 761 738 662 473 M11035 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. 13/36 Gene Ontology BP GO:0045686 0.0839184282471183 0.158445571591463 575 1055.27272727273 739 0.00793650793650794 127 0.849254971022537 0.849254971022537 1 2.57929132622512 574 127 2415 756 1256 562 485 846 702 3146 739 474 M14615 GO_MUSCLE_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_FATE_COMMITMENT.html The process in which the cellular identity of muscle cells is acquired and determined. 4/19 Gene Ontology BP GO:0042693 1.33464860089784e-05 0.000306106020068884 2860 1637.27272727273 740 1.33465661675659e-06 10 1.57303298172666 -1.57303298172666 -1 20.9827618719883 2856 582 4258 421 10 2357 3605 740 204 369 2608 475 M10405 GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. 9/30 Gene Ontology BP GO:0001516 0.0358019396032671 0.0967569299056863 645 1107.90909090909 741 0.00363921680392962 172 1.29064118907003 1.29064118907003 1 4.96920427682324 641 741 3579 872 1704 514 318 1610 172 1582 454 476 M12633 GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 7/15 Gene Ontology BP GO:0006244 0.00467621969488274 0.024070607586852 740 1202.90909090909 741 0.000468608910051763 59 1.0296882537552 -1.0296882537552 -1 6.32599970680562 740 1871 3942 2142 513 59 193 741 1492 1405 134 477 M16690 GO_PROSTANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. 9/30 Gene Ontology BP GO:0046457 0.0358019396032671 0.0967569299056863 645 1204.18181818182 742 0.00363921680392962 173 1.29064118907003 1.29064118907003 1 4.96920427682324 642 742 4606 873 1705 515 319 1581 173 1635 455 478 M13473 GO_FACE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FACE_DEVELOPMENT.html The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. 36/90 Gene Ontology BP GO:0060324 0.0191758273406013 0.0642840190197919 260 753.454545454545 744 0.00175863979976452 257 1.39073582769702 1.39073582769702 1 6.29202722429583 257 788 744 936 1438 1109 436 434 1338 393 415 479 M15089 GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. 76/213 Gene Ontology BP GO:0045834 0.000121587164112775 0.00167516083969025 635 891 745 1.1053989488865e-05 167 1.28694772037216 1.36336442326431 1 13.5605953459872 635 502 264 167 735 1780 1629 904 1419 745 1021 480 M13871 GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that activates or increases the frequency, rate, or extent of tissue remodeling. 11/31 Gene Ontology BP GO:0034105 0.0254904803379389 0.0778633554006911 1250 870.090909090909 748 0.00234460994524175 348 1.91509024629137 1.91509024629137 1 8.0593042467461 420 971 1249 401 1383 507 348 495 1246 1803 748 481 M11440 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. 166/433 Gene Ontology BP GO:0030111 0.00102469381298433 0.00817466215410008 1300 1263 750 9.3197399634985e-05 196 1.49167984200307 1.58341304115355 1 11.8199493712054 1300 196 378 481 750 4264 2436 555 1426 464 1643 482 M15783 GO_RESPONSE_TO_CYTOKINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CYTOKINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 393/1023 Gene Ontology BP GO:0034097 0.000170170547371699 0.00217279759769568 490 862.727272727273 750 1.54712465028592e-05 252 1.48861825945574 1.56402056866274 1 15.0473005744708 489 1508 277 1078 1106 1806 567 252 999 658 750 483 M10525 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 69/187 Gene Ontology BP GO:0014066 0.0145059081707474 0.0529905048283087 250 945.454545454545 752 0.00132749514384775 248 1.5276415506952 1.5276415506952 1 7.39795955461649 248 507 1245 839 482 525 623 977 1602 2600 752 484 M10825 GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. 12/22 Gene Ontology BP GO:0034114 3.53543929851213e-05 0.000636242041201233 605 860.727272727273 752 3.21408737721042e-06 9 2.02581632301012 2.02581632301012 1 24.5790662839799 603 822 931 408 3958 785 752 9 117 816 267 485 M16445 GO_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cell proliferation. 806/2183 Gene Ontology BP GO:0042127 0.033380677754907 0.0930291037311123 495 1236.36363636364 753 0.00338929631048547 396 1.33240388405745 1.38353674538368 1 5.2162970668506 495 753 4568 587 1422 1610 553 596 1592 396 1028 486 M10841 GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 247/769 Gene Ontology BP GO:0071407 3.91245142504449e-06 0.00010727586916864 160 649.272727272727 755 3.55678034810419e-07 156 1.39130575845553 1.44269917862463 1 20.9635774145961 380 995 159 223 1210 915 755 493 1098 758 156 487 M14584 GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. 189/605 Gene Ontology BP GO:0051346 0.00337560318183571 0.0190436519723733 1115 963.272727272727 755 0.000307344885710933 7 1.45545163033885 1.5120103329619 1 9.50378307475788 1114 7 462 152 980 3281 1633 672 888 652 755 488 M12949 GO_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 69/175 Gene Ontology BP GO:0051591 0.000671937687916506 0.00626467205822558 655 872.636363636364 756 6.11039093730237e-05 254 1.1980303444523 1.24776887112303 1 10.0186588096443 652 934 342 604 254 1195 756 1198 1446 651 1567 489 M16332 GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. 24/56 Gene Ontology BP GO:1904031 0.00142698627438642 0.00999113314352954 570 1362.45454545455 756 0.000129810245641202 54 1.18842414763347 1.18842414763347 1 9.0238598798448 567 3627 2051 2621 1066 404 54 756 3025 751 65 490 M10869 GO_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WOUNDING.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. 333/807 Gene Ontology BP GO:0009611 8.5119902617834e-09 6.08018012084005e-07 315 823.818181818182 758 7.73817299519727e-10 65 1.33075161397041 1.38941277482361 1 31.3993802454892 315 758 65 653 1129 2065 1256 358 911 349 1203 491 M15624 GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. 293/689 Gene Ontology BP GO:0071900 0.0019216392841511 0.0125841624771701 290 956.272727272727 758 0.00017484725804332 68 1.45185346633187 1.45921729310071 1 10.4718586854348 290 2330 758 844 3030 157 291 540 1076 1135 68 492 M10516 GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. 28/70 Gene Ontology BP GO:0055024 0.0188232300014907 0.0634225376610461 2010 1840.81818181818 759 0.00172602161492674 265 1.39003161840708 1.46935792733956 1 6.31975736642397 2009 527 646 498 759 4447 3045 4463 755 265 2835 493 M12944 GO_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MORPHOGENESIS.html The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. 30/93 Gene Ontology BP GO:0048813 0.00109945016496701 0.00830040181453953 390 1086.09090909091 759 1e-04 99 1.6193223060953 1.6193223060953 1 12.7906296418626 390 1585 1021 99 4251 1054 1129 759 519 525 615 494 M10876 GO_NEGATIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. 108/243 Gene Ontology BP GO:0030308 0.00219460733130184 0.0139774510826261 600 823.909090909091 760 0.000199709056497957 216 1.5317139388089 1.4824752440846 1 10.7827267234705 599 1209 429 619 1355 1192 1317 760 899 216 468 495 M13575 GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. 51/151 Gene Ontology BP GO:1901343 1.53861506544891e-06 4.82688496545899e-05 80 801.636363636364 760 1.39874194682903e-07 76 1.37724160273109 1.37553779205812 1 22.5648427796024 76 1010 142 1002 1783 760 406 694 1768 394 783 496 M13531 GO_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SIZE.html Any process that modulates the size of a cell. 113/258 Gene Ontology BP GO:0008361 0.00274735161506741 0.0163958271834936 765 1087.54545454545 761 0.000250071682505974 356 1.24364183869392 1.28889195142726 1 8.42763371264324 761 356 450 682 2612 1421 978 1553 2057 513 580 497 M16960 GO_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. 90/259 Gene Ontology BP GO:0048592 0.00423171449701208 0.022305944159712 765 1075.18181818182 762 0.000385443292270177 203 1.38135791273014 1.5300881528308 1 8.65990056460069 762 217 479 759 1761 2505 1790 880 615 203 1856 498 M11892 GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. 154/400 Gene Ontology BP GO:1901565 0.000133202319918687 0.00180660437979076 2125 1266.72727272727 763 1.21100350488953e-05 173 1.38632445714455 1.61392259019243 1 14.4350936177835 2122 198 268 173 553 3797 2615 811 763 272 2362 499 M10222 GO_SULFUR_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 185/421 Gene Ontology BP GO:0006790 0.00780347205031603 0.0342452936952905 3325 1235.36363636364 764 0.000711935405145033 6 1.35435197676563 1.57542093605363 1 7.53346368213563 3321 6 548 386 606 126 2148 3829 764 805 1050 500 M13563 GO_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENTATION.html The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. 48/137 Gene Ontology BP GO:0035282 0.00265861941014963 0.0161083144290426 1240 796.454545454545 765 0.000241985245499557 59 1.50276741612087 -1.13025447328655 -1 10.2274450708508 1239 59 515 733 168 1082 917 1274 765 586 1423 501 M16378 GO_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 153/370 Gene Ontology BP GO:0009612 6.89539453595285e-05 0.00106717722768097 350 919.090909090909 766 6.26873696885069e-06 243 1.61455811910393 1.62135863742026 1 18.21273426582 350 1416 243 790 1588 2255 1304 445 683 270 766 502 M15911 GO_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. 177/435 Gene Ontology BP GO:0001525 4.64926745966792e-09 3.6587370873285e-07 50 700.363636363636 768 4.2266067904484e-10 46 1.57158843255063 1.57507093720898 1 38.3978773874906 46 924 59 870 1490 598 327 796 1527 299 768 503 M14273 GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 126/288 Gene Ontology BP GO:0010810 1.48694763370644e-06 4.72869716664314e-05 535 1082.63636363636 772 1.35177148973947e-07 140 1.45746069843431 1.46315173351701 1 23.9285372842964 532 1001 140 502 1837 2889 1697 538 772 317 1684 504 M13027 GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION.html Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. 11/34 Gene Ontology BP GO:0060142 0.0015913249005542 0.0109621980909097 90 973.909090909091 773 0.000144770647252365 87 1.42043394401061 1.42043394401061 1 10.5683460028878 555 2312 1128 1397 967 360 89 124 2921 773 87 505 M11475 GO_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 277/850 Gene Ontology BP GO:0031175 5.13319752470343e-06 0.00013314768774971 775 774.727272727273 774 4.66655409262415e-07 15 1.44405722358179 1.53231022092697 1 21.2440844439103 470 993 167 135 1803 1194 1401 774 796 15 774 506 M13343 GO_PALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. 98/287 Gene Ontology BP GO:0021543 0.00507165343326734 0.0253473486444137 1150 866.454545454545 775 0.000462125724945104 228 1.40689535907282 1.50402368057456 1 8.52354526752707 775 494 501 708 784 2028 1148 1150 1461 254 228 507 M16308 GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 25/46 Gene Ontology BP GO:0060444 0.00230387656651666 0.014435760996406 2820 1777.63636363636 776 0.000209662978863015 85 1.31042028563858 -1.23094733005952 -1 9.15520119430348 2820 85 776 168 153 4272 3214 3726 336 423 3581 508 M14682 GO_KIDNEY_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. 9/27 Gene Ontology BP GO:0072074 0.000999550119979004 0.00804317366908581 1505 1065.63636363636 777 1e-04 10 1.74040550800543 1.85748458485995 1 13.8373551793423 1501 568 4273 15 431 1236 1267 777 10 95 1549 509 M10810 GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 530/1413 Gene Ontology BP GO:0045937 0.00394870433800588 0.021268949235918 445 1030.27272727273 779 0.00039557384553083 138 1.41128547760069 1.47662059673817 1 8.95827392450812 443 756 3641 217 1449 1633 844 363 1070 138 779 510 M11970 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 10/37 Gene Ontology BP GO:0050716 0.00285373159845113 0.016755804355697 765 1144.63636363636 779 0.000259767277710446 83 1.49867453025741 1.49867453025741 1 10.1022264708845 765 2227 981 2019 2546 153 150 779 2167 721 83 511 M13024 GO_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 45/116 Gene Ontology BP GO:0048145 0.00109945016496701 0.00830040181453953 1385 1190.81818181818 779 1e-04 70 1.45201868929671 1.45201868929671 1 11.4691394158652 1384 779 709 70 103 2548 1388 3267 409 189 2253 512 M10302 GO_MAMMARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_MORPHOGENESIS.html The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 40/77 Gene Ontology BP GO:0060443 0.00956699181242351 0.0392592104060817 2500 1754.63636363636 780 0.000873531836868484 64 1.22841944363622 1.22673418602069 1 6.5562768544496 2497 64 780 156 372 3958 2421 4151 451 753 3698 513 M12940 GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 530/1413 Gene Ontology BP GO:0010562 0.00394870433800588 0.021268949235918 445 1070.81818181818 780 0.00039557384553083 139 1.41128547760069 1.47662059673817 1 8.95827392450812 444 757 3985 218 1450 1634 845 456 1071 139 780 514 M10478 GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of cholesterol homeostasis. 6/18 Gene Ontology BP GO:2000188 0.0157280257580525 0.0559808131074437 355 1102.18181818182 781 0.00158404642529102 355 1.61212542072576 1.61212542072576 1 7.66119977844412 355 2142 3594 781 611 810 930 414 1238 495 754 515 M13764 GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. 4/27 Gene Ontology BP GO:0060219 0.0639904641340671 0.145927173366637 775 1300.45454545455 783 0.00659114395614618 503 1.31505585488108 1.31505585488108 1 4.17240985700871 771 585 4130 694 2424 683 503 783 1645 1100 987 516 M12310 GO_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 929/2794 Gene Ontology BP GO:0009605 5.34635110510743e-05 0.000883384632776292 480 1062.45454545455 784 5.34647973507852e-06 28 1.44005332210727 1.53147877148736 1 16.6929667617528 480 322 3889 304 1178 2036 909 784 1046 28 711 517 M15830 GO_POST_ANAL_TAIL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_ANAL_TAIL_MORPHOGENESIS.html The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. 18/44 Gene Ontology BP GO:0036342 0.0162957775361835 0.0574078933750904 2530 1501.72727272727 792 0.00149252271866566 238 1.71146074014946 1.71146074014946 1 8.06224308943179 2528 728 792 238 522 4081 2401 1670 384 569 2606 518 M12511 GO_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 47/116 Gene Ontology BP GO:0006029 0.00230108391719008 0.014435760996406 925 947 793 0.000209408569074354 209 1.36502036197784 1.3504844105203 1 9.53666253887997 922 245 431 209 749 2787 1065 793 1377 330 1509 519 M16887 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. 152/394 Gene Ontology BP GO:0032102 1.07328356919094e-06 3.61105479112573e-05 740 1166.54545454545 793 9.75712811635729e-08 39 1.46143147249082 1.54979982996363 1 24.6433653559373 736 197 135 39 1779 3187 2301 1079 793 188 2398 520 M10045 GO_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_RHYTHM.html Any biological process in an organism that recurs with a regularity of approximately 24 hours. 68/192 Gene Ontology BP GO:0007623 0.039468565022924 0.104061639637386 795 972.090909090909 795 0.00365408657077928 413 1.10229215555265 1.15097063705336 1 4.11177204537047 791 773 795 1215 851 963 743 1319 2110 413 720 521 M11712 GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 28/69 Gene Ontology BP GO:0070849 0.00598532410888402 0.0283859651047482 790 857.818181818182 795 0.000545606371461058 247 1.4171363529209 1.4171363529209 1 8.32108734146709 788 1103 904 577 795 1932 916 247 1341 485 348 522 M14282 GO_METANEPHRIC_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. 9/23 Gene Ontology BP GO:0072075 0.000999550119979004 0.00804317366908581 1500 1061.27272727273 795 1e-04 9 1.74040550800543 1.85748458485995 1 13.8373551793423 1500 567 4216 14 430 1235 1266 795 9 94 1548 523 M10966 GO_CELLULAR_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 10/27 Gene Ontology BP GO:0071285 0.00137320778060459 0.00973405148907956 430 1178.45454545455 797 0.000124915060595983 59 1.35603070540226 1.35603070540226 1 10.3547911491726 430 3256 1464 1969 2807 234 160 110 797 1677 59 524 M16059 GO_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 391/1000 Gene Ontology BP GO:0030162 0.00508396352001205 0.0253630798097571 1490 1098.63636363636 798 0.000463250014875593 275 1.32425719552434 1.42772881655364 1 8.02153517223709 1489 468 502 275 276 3466 1935 365 1132 798 1379 525 M14748 GO_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY.html The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. 22/45 Gene Ontology BP GO:0014896 0.0326880681123288 0.0917043506015362 355 926.181818181818 799 0.00301673671568927 353 1.70820157422404 1.70820157422404 1 6.7279154132511 353 799 1158 1217 774 370 601 1098 906 2363 549 526 M11066 GO_RESPONSE_TO_PHENYLPROPANOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PHENYLPROPANOID.html Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. 5/17 Gene Ontology BP GO:0080184 0.0765897756730953 0.158445571591463 505 1095 800 0.00793650793650794 122 2.51960658933014 2.51960658933014 1 7.65235370224517 501 449 3682 122 1410 676 800 1722 134 1185 1364 527 M12159 GO_MOTOR_NEURON_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_NEURON_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. 19/55 Gene Ontology BP GO:0008045 0.00436881148833615 0.0228427834913792 870 1040.81818181818 800 0.000397955579370314 237 1.54875060791287 1.54875060791287 1 9.6485870278241 867 883 800 752 237 1642 2056 2357 526 597 732 528 M16273 GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 35/95 Gene Ontology BP GO:0014068 0.0180291604889471 0.0616870981209885 185 869.181818181818 801 0.0016526025885037 182 1.5276415506952 1.5276415506952 1 7.01526862016258 182 1581 960 801 1360 343 451 563 1190 1900 230 529 M13509 GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 578/1576 Gene Ontology BP GO:0044092 0.0293710838749038 0.0848071781288422 940 1271.54545454545 804 0.00297666596303508 173 1.33905031640004 1.42521044461811 1 5.44657658974309 940 173 4089 191 770 3741 1273 804 1087 345 574 530 M12057 GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 48/106 Gene Ontology BP GO:0010812 0.00134132341291119 0.00967044193501032 405 1073.36363636364 805 0.000122012900582664 396 1.30306631891273 1.30306631891273 1 9.96443306849509 404 871 396 504 1008 3085 2154 626 805 585 1369 531 M14941 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 22/70 Gene Ontology BP GO:0009948 0.000139702844842215 0.00185577702597249 805 755.545454545455 805 1.27010651765699e-05 31 1.42204638869366 1.53848639069916 1 14.7440942559831 543 805 1058 1099 31 803 887 1083 795 358 849 532 M15388 GO_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_SECRETION.html Any process that modulates the frequency, rate, or extent of peptide secretion. 126/327 Gene Ontology BP GO:0002791 0.010381922847563 0.0416983285304803 380 1357.27272727273 805 0.000948294715027701 325 1.206726243368 -0.950120871622752 -1 6.32059167359838 378 2801 678 2103 1865 650 805 325 2460 2138 727 533 M11346 GO_APOPTOTIC_CELL_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_CELL_CLEARANCE.html The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. 19/46 Gene Ontology BP GO:0043277 0.0031325011170631 0.0179653064479894 835 905.818181818182 807 0.0002851791167735 177 1.39037427454502 1.39037427454502 1 9.21244848191368 625 807 831 1169 2313 1488 420 177 831 596 707 534 M15753 GO_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. 218/611 Gene Ontology BP GO:0048732 3.41405525709542e-05 0.000622658752658488 1020 927.272727272727 807 3.10373476275838e-06 61 1.27362808252974 1.34312426008224 1 15.4981369840077 1020 187 216 61 773 2073 1271 1854 807 307 1631 535 M16514 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 23/77 Gene Ontology BP GO:1903556 0.00123221990088159 0.00905907429171421 375 792.272727272727 807 0.000112082782624089 102 1.46516862981315 1.46516862981315 1 11.3617542244081 371 1593 476 1167 807 856 869 102 1760 389 325 536 M10499 GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the rate of skeletal muscle tissue development. 14/40 Gene Ontology BP GO:0048643 1.85925199021945e-05 0.000399653101416153 490 1218.90909090909 808 1.69024336655844e-06 4 1.55178359343141 1.55178359343141 1 20.017150342611 487 2855 808 1942 2867 348 423 4 1559 2007 108 537 M15511 GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT.html Any process that modulates the frequency, rate or extent of the movement of a cellular component. 450/1139 Gene Ontology BP GO:0051270 1.64930338029386e-16 1.9144288986761e-13 215 746 808 1.49936670935805e-17 4 1.39429736133044 1.3995180319529 1 67.3100816203878 214 850 4 808 1424 1454 707 531 1039 195 980 538 M12510 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. 79/170 Gene Ontology BP GO:0033135 6.20467439757321e-05 0.00097655265179432 160 884.545454545455 809 5.64077217756455e-06 10 1.96629678935523 1.96629678935523 1 22.4681184802794 156 2481 809 1726 2285 39 156 80 860 1128 10 539 M16534 GO_BIOLOGICAL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOLOGICAL_ADHESION.html The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. 492/1424 Gene Ontology BP GO:0022610 1.73413230633916e-21 8.05157629833273e-18 145 709.818181818182 812 1.57648391485378e-22 1 1.54115402105978 1.5818201875587 1 100 141 848 1 385 1902 983 669 1182 812 11 874 540 M10495 GO_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WOUND_HEALING.html Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 76/209 Gene Ontology BP GO:0061041 4.17668012873536e-06 0.000111450148492634 835 945 813 3.79698914376903e-07 164 1.7142449873504 1.81251649609508 1 25.7216054860557 834 367 164 253 1251 2040 1528 359 813 743 2043 541 M13393 GO_MUSCLE_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_MORPHOGENESIS.html The process in which the anatomical structures of muscle are generated and organized. 51/133 Gene Ontology BP GO:0048644 5.68423384739075e-09 4.39864962557254e-07 815 1321.36363636364 813 5.16748532916122e-10 60 1.71855941663884 1.49958962882334 1 41.4669578451739 813 613 60 598 1138 3490 2203 2884 578 62 2096 542 M14280 GO_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_CHEMOTAXIS.html The directed movement of a lymphocyte in response to an external stimulus. 13/56 Gene Ontology BP GO:0048247 0.000831706070721666 0.0071379136531621 450 946.909090909091 813 7.5638242021082e-05 35 1.45023161899474 1.45023161899474 1 11.8157439042881 447 1908 823 1787 1336 474 35 813 653 1951 189 543 M13680 GO_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTION.html Self-propelled movement of a cell or organism from one location to another. 550/1674 Gene Ontology BP GO:0040011 0.000355132903151968 0.00376457093455385 290 995.090909090909 814 3.55189669640666e-05 55 1.40096132639929 1.45896336755616 1 12.891901103714 287 329 4114 307 1217 1366 967 577 913 55 814 544 M14992 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 742/1992 Gene Ontology BP GO:0048585 0.00153085544082074 0.010608599719001 435 1173.90909090909 816 0.000153191104769075 93 1.3210938900248 1.3995949246487 1 9.90064036973972 433 1063 4333 461 790 2002 1006 373 1543 93 816 545 M15608 GO_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_GUIDANCE.html The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. 96/347 Gene Ontology BP GO:0097485 3.30853716800074e-05 0.000614461522841098 930 680.454545454545 816 3.00780629590425e-06 86 1.4266142611073 1.42102688736865 1 17.3909151520915 243 493 214 816 926 902 1040 742 927 86 1096 546 M15319 GO_PROTEIN_HOMOTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTRIMERIZATION.html The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. 13/23 Gene Ontology BP GO:0070207 0.0540668319674874 0.129732455206741 635 1377.72727272727 820 0.00504028757259552 293 1.5361147374397 1.5361147374397 1 5.17166865494391 634 1975 1350 672 4405 820 369 3205 293 885 547 547 M13011 GO_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a cell population. 391/1073 Gene Ontology BP GO:0008283 6.01349085479329e-05 0.000956186234205659 580 746.272727272727 821 5.46695930376315e-06 205 1.37759644168209 1.40700878817761 1 15.7891287593626 577 854 237 628 832 1524 547 821 938 205 1046 548 M13029 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 12/19 Gene Ontology BP GO:2001241 0.00160046898591085 0.0110088555579024 2400 1481.90909090909 821 0.000145603135613941 76 1.69807544305201 1.69807544305201 1 12.6221716944542 2399 293 1717 588 214 3578 4632 125 76 821 1858 549 M13978 GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 42/103 Gene Ontology BP GO:0061178 0.00207834499916686 0.0133747172422348 825 978.181818181818 822 0.000189119183374946 145 1.29373002335139 1.21852307691006 1 9.20141274234443 822 780 888 748 145 1832 338 840 1895 801 1671 550 M13722 GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 59/172 Gene Ontology BP GO:0010906 0.0367675656307041 0.0986203392393756 610 966 824 0.00339971071009893 44 1.38865035931986 1.38865035931986 1 5.30288962692001 607 44 1011 824 817 1318 1892 687 972 1846 608 551 M13111 GO_OPTIC_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPTIC_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. 11/26 Gene Ontology BP GO:0021554 0.0197872859698078 0.0656231205412982 1365 1082.90909090909 825 0.00181523008590581 246 1.41412268034735 1.41412268034735 1 6.34977274164953 1362 825 1429 755 1053 2256 808 2033 371 774 246 552 M10413 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION.html The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. 3/21 Gene Ontology BP GO:0021843 0.0105579533233443 0.0421138980071201 1250 1226.90909090909 826 0.00106084529986205 130 1.14672566625037 1.14672566625037 1 5.98757407312936 1247 454 3581 796 2019 2682 826 595 130 981 185 553 M10666 GO_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COAGULATION.html Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. 48/144 Gene Ontology BP GO:0050818 1.44113995704638e-07 6.97001335475661e-06 85 762.818181818182 826 1.3101273195002e-08 83 1.8260407640843 1.89555991672149 1 35.7433420388477 83 1153 96 1115 2200 511 302 292 826 933 880 554 M12613 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION.html The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. 3/21 Gene Ontology BP GO:0021826 0.0105579533233443 0.0421138980071201 1250 1259.63636363636 827 0.00106084529986205 131 1.14672566625037 1.14672566625037 1 5.98757407312936 1248 455 3937 797 2020 2683 827 589 131 983 186 555 M10101 GO_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 336/1049 Gene Ontology BP GO:0048666 4.20927372276235e-07 1.63991377197629e-05 515 863.636363636364 829 3.82661320738686e-08 30 1.42591985775074 1.51942932549442 1 25.9000459866858 515 991 116 530 1930 1601 1352 657 829 30 949 556 M13480 GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. 20/47 Gene Ontology BP GO:0000038 0.0162458140039352 0.0573171082220906 830 1452.90909090909 829 0.00148791233350968 265 0.722840167654169 -0.722840167654169 -1 3.40699653119099 829 1384 2939 2721 519 265 649 601 1885 3751 439 557 M12996 GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS.html The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. 9/15 Gene Ontology BP GO:0019184 0.00285458566559473 0.016755804355697 580 1406.27272727273 830 0.000285825920543852 142 0.874649861425705 -0.874649861425705 -1 5.89581713997781 580 830 3992 1157 185 142 639 1231 2616 3623 474 558 M11052 GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. 15/43 Gene Ontology BP GO:0045939 0.00691118251350704 0.0312754584894865 925 1175.54545454545 831 0.000630271781169052 110 1.10233815472542 1.00672811381994 1 6.29650843931608 925 110 1451 330 3507 831 274 4178 237 957 131 559 M10954 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. 38/71 Gene Ontology BP GO:2001021 0.00176519131503988 0.0117945758525033 900 994.727272727273 832 0.00016060083876314 128 1.85580337477035 1.85580337477035 1 13.5836903396944 896 1579 2506 832 128 1617 548 156 326 1988 366 560 M16772 GO_MALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DIFFERENTIATION.html The establishment of the sex of a male organism by physical differentiation. 97/273 Gene Ontology BP GO:0046661 0.00626668203475815 0.0293013138845741 3550 1816.27272727273 834 0.000571327649051763 286 1.41329705441301 1.62940194875823 1 8.22460073619827 3547 765 834 669 286 1698 4427 3924 707 536 2586 561 M10993 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte migration. 16/39 Gene Ontology BP GO:2000403 0.0191999630353107 0.0643184908895726 1765 1358.81818181818 835 0.00176087294195074 328 1.22779392099841 -0.989745402399581 -1 5.55375331601834 1764 550 649 540 789 3338 1543 835 328 2102 2509 562 M16185 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 6/23 Gene Ontology BP GO:0032700 0.00843648996183149 0.0362020544295597 200 1635.09090909091 835 0.000846869061039267 196 0.410348151864717 -0.410348151864717 -1 2.24493665111644 835 1711 4525 1992 367 199 196 548 2644 4436 533 563 M16583 GO_HEMOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOSTASIS.html The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. 183/448 Gene Ontology BP GO:0007599 2.9473847216272e-05 0.000564283240835162 420 802 835 2.67947655370917e-06 208 1.40941797302078 1.47154669497775 1 17.3792202957553 418 923 208 1161 502 1697 1373 397 835 237 1071 564 M11082 GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC.html The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine. 6/32 Gene Ontology BP GO:0007271 0.00455338999645912 0.0235472828164902 455 1569.54545454545 837 0.000456274700382174 112 0.609579925454239 0.671727149730845 1 3.76710807876507 455 837 3685 1522 4183 485 260 614 1951 3161 112 565 M13558 GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 732/2007 Gene Ontology BP GO:1901700 0.00439756127840571 0.0229672407375002 395 1170.09090909091 837 0.00044062879383787 147 1.34220146299111 1.43492212269293 1 8.34978044983607 392 459 4096 310 1357 1935 837 662 1567 147 1109 566 M10893 GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. 4/48 Gene Ontology BP GO:0042738 0.0102727105852265 0.0413524357861842 265 1274.54545454545 838 0.00103205097255077 163 2.01369544572059 2.01369544572059 1 10.5749869076086 262 1560 3653 660 2637 244 163 838 2480 1089 434 567 M13069 GO_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JNK_CASCADE.html An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 39/112 Gene Ontology BP GO:0007254 0.0647500464898654 0.146900707449814 720 1619.09090909091 838 0.00606710718206421 584 1.83179983466004 1.83179983466004 1 5.79185650910845 720 2449 2514 2823 3782 692 584 761 608 2039 838 568 M14969 GO_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of MAP kinase activity. 194/484 Gene Ontology BP GO:0043405 0.0526591268175458 0.127209326646132 345 985.272727272727 841 0.00490577265146497 344 1.42603533216285 1.42603533216285 1 4.84723321003128 344 1207 882 841 3070 363 475 719 1037 1467 433 569 M15093 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. 11/16 Gene Ontology BP GO:0010667 0.00547540059757087 0.0266760597843878 125 821.454545454545 842 0.000499006867969069 107 2.03139865611857 2.03139865611857 1 12.1359434575925 1171 1704 1351 294 1517 842 107 1028 125 775 122 570 M11767 GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 82/223 Gene Ontology BP GO:0043433 0.010358195988433 0.0416390510599951 300 732 843 0.000946117189879899 152 1.3509347991263 1.45162284354348 1 7.07909551186041 298 1083 1436 1284 1212 163 152 486 848 843 247 571 M14306 GO_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JNK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. 103/282 Gene Ontology BP GO:0046328 0.040229496403145 0.105409453611626 660 984.909090909091 844 0.00372586729017417 532 1.55408684306855 1.55408684306855 1 5.76408812586189 659 1210 844 1052 861 1123 724 778 820 2231 532 572 M12263 GO_PROXIMAL_DISTAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROXIMAL_DISTAL_PATTERN_FORMATION.html The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). 18/48 Gene Ontology BP GO:0009954 0.0227630072388721 0.0719949881540076 610 1396.63636363636 845 0.00209109102014207 481 1.80540289925521 1.80540289925521 1 7.83091902704836 609 2425 1310 1792 3641 745 512 481 809 2194 845 573 M11488 GO_MICROTUBULE_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_NUCLEATION.html The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). 6/24 Gene Ontology BP GO:0007020 0.0205207877612773 0.0670971954757821 850 1469.36363636364 846 0.00207127840142327 243 0.493393016758395 -0.493393016758395 -1 2.19739273001376 754 2544 3757 2438 846 243 671 478 849 3268 315 574 M14234 GO_NEGATIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GROWTH.html Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. 136/323 Gene Ontology BP GO:0045926 0.0015488253132967 0.0107011844191021 405 844.545454545455 847 0.000140901525459721 158 1.43875870011939 1.39343149435819 1 10.7618430310922 629 1142 405 158 884 1683 1991 847 879 271 401 575 M13922 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). 121/264 Gene Ontology BP GO:0097193 0.000620998333572835 0.0058603562251599 550 1368.36363636364 848 5.64703357544002e-05 34 1.5352038303355 1.5352038303355 1 13.0071530707117 546 2872 1791 2859 335 388 759 848 2136 2484 34 576 M10808 GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. 55/184 Gene Ontology BP GO:0048706 0.000256124606524166 0.00287938631499202 285 858.545454545455 849 2.32867663165799e-05 168 1.56769664066824 1.56769664066824 1 15.1189857351634 283 1152 301 1055 613 1909 849 412 1392 168 1310 577 M10927 GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. 47/145 Gene Ontology BP GO:0048704 0.00123311112478212 0.00905907429171421 230 852.909090909091 851 0.000112163893877455 202 1.58042841580212 1.58042841580212 1 12.2555444228455 228 1093 389 1051 741 1632 851 567 1384 202 1244 578 M14294 GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. 55/211 Gene Ontology BP GO:0050830 0.00454613371529897 0.0235472828164902 1225 930.545454545455 853 0.000414141384060945 472 1.23264142439147 -1.20074158169684 -1 7.61753016176782 1221 612 487 853 532 472 1495 954 741 1735 1134 579 M10308 GO_BODY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_MORPHOGENESIS.html The process in which the anatomical structures of the soma are generated and organized. 34/79 Gene Ontology BP GO:0010171 0.0340914171692388 0.0939943289292016 270 943.363636363636 854 0.003148313996465 268 1.38666461414351 1.38666461414351 1 5.40512969849596 268 1159 854 1188 2077 1469 491 572 1348 340 611 580 M12853 GO_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_GROWTH.html Any process that modulates the frequency, rate or extent of growth of an organ of an organism. 40/110 Gene Ontology BP GO:0046620 0.0315603719802785 0.089296043329941 1680 1667.81818181818 855 0.00291113020321747 157 1.36291347667642 1.42095089547628 1 5.42775784333151 1677 388 721 157 760 4000 2586 4470 855 452 2280 581 M15176 GO_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. 358/940 Gene Ontology BP GO:0030155 6.84133603344165e-12 1.44383287287589e-09 275 922.272727272727 855 6.21939639405721e-13 22 1.44199580502982 1.4607023950379 1 48.3890643908265 275 855 22 730 1838 1949 1144 605 1057 372 1298 582 M12216 GO_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_DEVELOPMENT.html The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 45/114 Gene Ontology BP GO:0001892 0.00109945016496701 0.00830040181453953 1540 1263.63636363636 856 1e-04 40 1.30789103854835 1.30789103854835 1 10.3307104601469 1538 58 574 40 202 2760 2106 3003 373 856 2390 583 M12870 GO_POSITIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION.html Any process that activates or increases the frequency, rate or extent of cell adhesion. 225/579 Gene Ontology BP GO:0045785 2.06153125747454e-08 1.27622528379391e-06 525 967.272727272727 857 1.87411934253847e-09 75 1.4697958587384 1.49930522914026 1 32.8836286786098 524 857 75 495 1468 2226 1422 820 889 329 1535 584 M15271 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 6/17 Gene Ontology BP GO:0044252 0.0524107137948843 0.126741116744608 340 1300.81818181818 857 0.00536894670964487 338 1.75718928906452 1.75718928906452 1 5.98353931389867 338 1130 4378 857 2249 591 385 1562 681 1335 803 585 M15330 GO_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron. 417/1295 Gene Ontology BP GO:0030182 1.67438630633594e-08 1.07974661393303e-06 635 886.545454545455 858 1.52216938098131e-09 19 1.39748469452005 1.51372947317305 1 31.6509611781722 632 467 72 245 1502 2286 1461 1016 858 19 1194 586 M11515 GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein oligomerization. 10/25 Gene Ontology BP GO:0032461 0.000338461759866845 0.00363768044227259 865 861 862 3.07739856508149e-05 51 1.86280643978199 1.86280643978199 1 17.2471763040731 862 1241 1059 878 1944 595 456 51 504 1682 199 587 M11724 GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 82/222 Gene Ontology BP GO:0070304 0.0379018584295248 0.100674101080254 1770 947.363636363636 862 0.00350645753762516 357 1.30442154563489 1.30442154563489 1 4.93692097035145 400 862 1064 1149 1766 611 609 853 981 1769 357 588 M10343 GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. 32/89 Gene Ontology BP GO:1904035 0.0423013266137831 0.109077806722957 975 848 864 0.00392157117422637 331 1.54370995284373 1.54370995284373 1 5.63854427000067 331 1161 864 683 973 1016 773 642 679 973 1233 589 M11140 GO_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING.html Any process that mediates the transfer of information from one cell to another. 311/1050 Gene Ontology BP GO:0007267 2.51484323536384e-06 7.34365857974486e-05 400 820.272727272727 867 2.28622373646573e-07 109 1.45218768769034 1.54510558727506 1 22.7881803649276 398 1136 150 525 1907 1169 867 1007 833 109 922 590 M10506 GO_ICOSANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. 22/58 Gene Ontology BP GO:0046456 0.0275620872486292 0.0811482378537636 730 1125.36363636364 868 0.00253759742936532 258 1.14894413261494 1.28609126820956 1 4.75685354308939 729 2666 1003 1519 2088 719 258 868 586 1258 685 591 M14878 GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. 98/266 Gene Ontology BP GO:0050866 3.3766644725752e-05 0.000622658752658488 375 998 869 3.06974209121699e-06 215 1.44766264375031 1.44766264375031 1 17.6158756761552 375 1470 215 1435 1949 1177 783 869 1199 797 709 592 M14988 GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 18/66 Gene Ontology BP GO:0071391 0.0027397146400114 0.0163712935309819 780 1184.81818181818 869 0.00024937567590494 78 1.66189029511037 1.66189029511037 1 11.2660287507779 778 3631 869 2088 564 663 873 1188 1734 567 78 593 M13002 GO_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. 149/391 Gene Ontology BP GO:0046883 0.00398410570730921 0.0214347656999266 395 1330.63636363636 870 0.000362849008885951 294 1.14652387926171 -0.893077690580479 -1 7.26299547013089 394 2589 475 2100 1830 522 870 294 2455 2456 652 594 M15563 GO_CAMP_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 3/14 Gene Ontology BP GO:0006198 0.00124381776352769 0.00912329522284211 815 1928.54545454545 870 0.000124451449962803 52 0.632474160443011 0.632474160443011 1 4.89720047688784 812 587 4423 2327 3873 275 52 870 3139 4308 548 595 M16339 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 28/52 Gene Ontology BP GO:0070059 0.000739743264620191 0.00665625577060377 540 999.636363636364 871 6.72720107438906e-05 74 1.88804590279963 1.88804590279963 1 15.6002774730022 540 1896 871 1718 74 863 635 1170 1511 1550 168 596 M10135 GO_METANEPHRIC_NEPHRON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. 10/29 Gene Ontology BP GO:0072273 0.0220354444032502 0.0703165418311277 2555 1388.45454545455 872 0.00202357265832028 32 1.71873971092217 1.88352542766232 1 7.52185555792214 2551 657 872 142 614 3300 2054 2770 32 311 1970 597 M15406 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 615/1669 Gene Ontology BP GO:0051094 1.92144825587493e-06 5.90813526624323e-05 485 1118.54545454545 875 1.92144991726047e-07 8 1.47042512474169 1.53766627422139 1 23.601606861149 484 679 4400 26 1300 2128 1016 374 875 8 1014 598 M12724 GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of natural killer cell activation. 13/34 Gene Ontology BP GO:0032814 0.012728640397983 0.0484418666949466 1210 914.181818181818 876 0.00116389883421779 288 1.51219857869234 1.51219857869234 1 7.54690456759198 1209 288 1227 343 534 1743 597 357 1672 876 1210 599 M14257 GO_HEAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_DEVELOPMENT.html The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. 399/1144 Gene Ontology BP GO:0060322 1.83455880763002e-08 1.16682966353783e-06 2010 1384.45454545455 876 1.66778074811657e-09 2 1.42137279201029 1.53675595831849 1 32.0102474308602 2007 853 73 203 680 2247 2784 2596 876 2 2908 600 M10708 GO_EMBRYONIC_DIGIT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGIT_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. 30/89 Gene Ontology BP GO:0042733 0.00564014193365217 0.0272001918240554 4170 1935.18181818182 877 0.000514059425687958 145 1.59677678677395 1.77954573526019 1 9.4882156800753 4170 263 877 145 715 3217 4368 2848 181 159 4344 601 M11803 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE.html Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. 30/118 Gene Ontology BP GO:0050885 0.000837591026032283 0.00716194315629446 1665 1357 877 7.61736442217107e-05 37 1.81611917212185 1.89031124948347 1 14.7867462627659 1661 877 361 37 4358 2191 2276 270 503 294 2099 602 M14813 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. 560/1430 Gene Ontology BP GO:0022603 4.00613403259041e-05 0.000704563648231716 630 1206.09090909091 877 4.00620625541737e-06 24 1.40787657707762 1.52694331098099 1 16.8449223781778 630 328 4297 309 1010 2761 1445 424 877 24 1162 603 M16485 GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin receptor signaling. 33/96 Gene Ontology BP GO:0046626 0.0056021893750715 0.0270867030454217 480 1409 877 0.000510591466759637 271 1.23719315255334 1.23719315255334 1 7.3600593089873 479 3045 1314 3084 271 367 877 739 2427 2592 304 604 M10798 GO_ENDOCARDIAL_CUSHION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_DEVELOPMENT.html The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 17/53 Gene Ontology BP GO:0003197 3.59216651504182e-05 0.000643954792638578 2125 1357.81818181818 879 3.26565924489441e-06 12 1.25636338514166 1.27311304870178 1 15.2183997807342 2121 276 484 476 12 2356 879 3579 1358 256 3139 605 M15813 GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of fatty acid derivative. 22/58 Gene Ontology BP GO:1901570 0.0275620872486292 0.0811482378537636 730 1128.36363636364 879 0.00253759742936532 259 1.14894413261494 1.28609126820956 1 4.75685354308939 730 2667 1004 1520 2089 720 259 879 587 1271 686 606 M14380 GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 103/383 Gene Ontology BP GO:0071383 0.000362297492422568 0.00381439287373692 1125 1151.45454545455 880 3.2941560870781e-05 316 1.43281531972947 1.50986834328334 1 13.1539725429959 1123 1629 316 657 514 1536 1424 3160 880 855 572 607 M15812 GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE.html Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. 7/23 Gene Ontology BP GO:0051969 0.0343702246457728 0.0945782144473027 530 1315.18181818182 880 0.00349136830599591 304 1.9083122944764 1.9083122944764 1 7.41899742264612 526 1814 4461 1497 880 446 304 622 1683 1428 806 608 M11901 GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of cell proliferation. 449/1274 Gene Ontology BP GO:0008284 5.47492025911626e-06 0.000139670630566356 885 868.090909090909 881 4.97721262186448e-07 72 1.33683400064263 1.38757824873531 1 19.561279406682 881 176 170 72 1115 2234 644 1103 1042 582 1530 609 M12866 GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. 959/2715 Gene Ontology BP GO:0071310 0.00112584744629129 0.0084292665549046 630 1208.09090909091 881 0.000112641824294483 81 1.39470633894443 1.46819372074452 1 10.9810223137131 626 845 3972 394 945 2410 881 1183 1089 81 863 610 M16354 GO_REGULATION_OF_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of organ morphogenesis. 130/309 Gene Ontology BP GO:2000027 0.0213247958605237 0.068541741741185 3230 1721.18181818182 881 0.00195766802502504 128 1.45278922437394 1.62541304134112 1 6.41918008869793 3226 201 735 128 881 3137 3356 1960 509 244 4556 611 M14197 GO_CELLULAR_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 13/32 Gene Ontology BP GO:0036315 0.00872028101618582 0.0368410052394456 2285 1288.27272727273 882 0.000795912653554254 139 1.34688065758334 1.61212542072576 1 7.32968142331129 2284 291 962 139 352 3415 3238 1793 187 882 628 612 M14556 GO_DIENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. 27/125 Gene Ontology BP GO:0021536 0.00560247226811226 0.0270867030454217 4250 1905.81818181818 882 0.000510617315993261 272 1.2469727600963 -1.17401620026265 -1 7.41823817248002 4247 530 791 300 272 3412 4624 2746 882 836 2324 613 M13631 GO_NEURON_PROJECTION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MORPHOGENESIS.html The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. 201/670 Gene Ontology BP GO:0048812 1.79982760535155e-05 0.000388679049844057 325 826.454545454545 883 1.63622029997459e-06 67 1.48866790939936 1.556350736727 1 19.2713219342715 322 1305 192 819 1927 934 970 673 883 67 999 614 M16739 GO_METANEPHROS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_MORPHOGENESIS.html The process in which the anatomical structures of the metanephros are generated and organized. 13/38 Gene Ontology BP GO:0003338 0.0208383919181166 0.0677539591567336 2325 1474.63636363636 883 0.00191258462238122 54 1.71873971092217 1.88352542766232 1 7.62704169572938 2325 733 883 149 596 2646 2035 4002 54 411 2387 615 M10106 GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 12/37 Gene Ontology BP GO:0010831 0.0521506649914904 0.126441533971535 890 1098.36363636364 886 0.00485723065109287 107 1.69515102423431 1.69515102423431 1 5.77890130600011 886 2428 1235 681 2622 1457 592 699 107 378 997 616 M10696 GO_SALIVARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SALIVARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. 18/55 Gene Ontology BP GO:0007431 0.00677258844049105 0.0309164982364579 420 858 886 0.00061759343740413 263 1.1109975320629 1.1109975320629 1 6.3671127017876 490 886 1301 1187 1263 416 418 263 1439 1062 713 617 M12413 GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 42/99 Gene Ontology BP GO:0070167 0.00623234482479391 0.0292290676985032 1570 1266.54545454545 886 0.000568188243286966 165 1.53013723799348 1.57702970493002 1 8.91077254728127 1569 384 537 269 1084 3046 3723 886 262 165 2007 618 M13648 GO_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 296/777 Gene Ontology BP GO:0007507 6.14590631582222e-07 2.24688527750886e-05 810 1242.18181818182 886 5.58718912067223e-08 120 1.53954808042599 1.54612444861134 1 27.1647532675959 806 1069 124 290 886 3417 2331 1482 841 120 2298 619 M14459 GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. 35/106 Gene Ontology BP GO:0046888 0.0215333623711478 0.0690942650236624 150 1444.81818181818 886 0.00197700570374689 149 1.16533572062244 1.16533572062244 1 5.1336367948999 149 2451 886 3227 2331 294 363 522 2319 2621 730 620 M16251 GO_REGULATION_OF_CELLULAR_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. 38/95 Gene Ontology BP GO:0030641 0.0360371663681359 0.0971534283090433 1000 1249.90909090909 887 0.00333103424882404 247 1.63683128916386 1.80389653778312 1 6.29106453243883 997 1893 861 732 4207 887 1004 591 247 705 1625 621 M15026 GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 515/1522 Gene Ontology BP GO:0071495 0.000193774702910593 0.00240560413265744 620 1118.81818181818 888 1.93791601870506e-05 45 1.39402716872165 1.45404783537507 1 13.8572417764209 620 591 4335 311 620 1357 888 1646 944 45 950 622 M10898 GO_OTIC_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OTIC_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. 15/42 Gene Ontology BP GO:0071599 2.7314927515526e-05 0.000544305615684925 225 793.818181818182 889 2.48320606001619e-06 203 1.46778240338295 1.46778240338295 1 18.1861166264718 221 729 203 889 906 971 717 949 1730 472 945 623 M10301 GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 204/507 Gene Ontology BP GO:0010721 1.53023486153299e-06 4.82688496545899e-05 810 1112.54545454545 890 1.39112356900561e-07 5 1.39054431947373 1.41693946857542 1 22.782795614636 807 5 141 346 1146 3515 2325 1030 890 247 1786 624 M14629 GO_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of B cell proliferation. 31/96 Gene Ontology BP GO:0030888 0.0266840490633251 0.0798286338924088 1390 846.636363636364 890 0.00245575524858138 489 1.3809894040836 1.3809894040836 1 5.75489154067951 1386 876 946 489 1089 933 568 508 677 951 890 625 M10722 GO_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that modulates the frequency, rate or extent of developmental growth. 164/478 Gene Ontology BP GO:0048638 0.000238014700966024 0.00275586597652182 895 1045.63636363636 892 2.16400413927767e-05 12 1.38260660658668 1.43562696653585 1 13.4338977188802 892 12 293 120 1096 3012 1609 2605 720 169 974 626 M11688 GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle tissue development. 67/167 Gene Ontology BP GO:1901861 0.00210521229764594 0.0135193647274828 230 1407.45454545455 892 0.000191566319012402 147 1.36926766931563 1.41163071026398 1 9.71437902305885 1804 230 595 229 147 4538 2621 2763 892 614 1049 627 M15877 GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the inflammatory response. 57/167 Gene Ontology BP GO:0050729 0.0136552197463492 0.0509655830243563 930 1115.45454545455 894 0.00124915640727078 612 1.57133308458781 1.57133308458781 1 7.71047196970808 929 1271 612 622 894 2609 1130 830 619 740 2014 628 M16170 GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. 30/62 Gene Ontology BP GO:0060603 0.00326137905119415 0.0185941547677909 1560 1197.09090909091 895 0.000296929447680508 75 1.31042028563858 -1.23094733005952 -1 8.60836057614089 1560 75 895 235 188 2690 1437 2959 341 526 2262 629 M16788 GO_LEUKOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. 38/87 Gene Ontology BP GO:0001776 0.00165662234390397 0.0112781488896571 830 1062.27272727273 896 0.000150715555820343 127 1.86257814601771 1.86257814601771 1 13.7707521581268 827 2999 1662 1546 1052 896 450 127 639 1132 355 630 M15050 GO_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 75/182 Gene Ontology BP GO:0032526 1.40449116132615e-06 4.49727756002574e-05 210 704.454545454545 898 1.27681096178294e-07 33 1.58104368116753 1.58104368116753 1 26.0882991715508 206 33 139 78 898 1687 929 1088 1404 119 1168 631 M11050 GO_LYMPHOCYTE_COSTIMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_COSTIMULATION.html The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. 37/114 Gene Ontology BP GO:0031294 0.0839184282471183 0.158445571591463 360 1466.54545454545 901 0.00793650793650794 359 1.41741861650407 1.41741861650407 1 4.30487388125335 359 3140 1223 2270 4256 893 946 862 901 687 595 632 M14227 GO_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of B cell activation. 56/269 Gene Ontology BP GO:0050864 0.00230071747291882 0.014435760996406 1425 990.454545454545 901 0.000209375186123425 152 1.38805169153262 1.38805169153262 1 9.69757004173326 1421 1474 901 818 152 1757 1037 829 675 716 1115 633 M11646 GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM.html The process in which the anatomical structures of embryonic epithelia are generated and organized. 86/203 Gene Ontology BP GO:0016331 0.0737009569795328 0.158445571591463 530 1025.90909090909 902 0.00693566880678268 529 1.37528672465425 1.37330364568459 1 4.17691416724388 529 768 1416 687 1833 1365 1057 800 640 902 1288 634 M12131 GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. 10/20 Gene Ontology BP GO:2000647 0.0358921849407136 0.0969443948107813 1670 1300.27272727273 905 0.00331740786419519 137 1.17471811835749 1.17471811835749 1 4.51913091215671 1669 137 2126 788 3015 2575 546 590 267 1685 905 635 M10576 GO_HEART_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 16/39 Gene Ontology BP GO:0061384 0.0204162355169848 0.0668023830199863 335 1175.09090909091 907 0.00187347264244205 223 1.39869528009495 1.39869528009495 1 6.23943257744296 332 1035 1800 1631 4475 516 223 907 484 996 527 636 M13942 GO_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_MORPHOGENESIS.html The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. 293/783 Gene Ontology BP GO:0048598 1.16399676445854e-08 7.94770143732497e-07 245 855.909090909091 907 1.0581788823792e-09 68 1.44950205304267 1.49628188422091 1 33.5612944912974 245 1070 68 904 1431 1565 1360 649 907 72 1144 637 M14446 GO_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_REGENERATION.html The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. 19/47 Gene Ontology BP GO:0031102 0.00658879391699189 0.0303489783299537 910 1155.45454545455 907 0.000600782715747283 62 2.05369581223184 2.05369581223184 1 11.8324287686172 907 542 1147 600 1327 2689 3226 260 62 1123 827 638 M13090 GO_CARDIAC_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_MORPHOGENESIS.html The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 47/124 Gene Ontology BP GO:0003208 7.56764149417194e-07 2.68218011125498e-05 910 1059.54545454545 910 6.87967645210776e-08 101 1.80133256083738 1.57473084453354 1 31.2579865864558 910 510 128 431 913 3050 1078 2134 520 101 1880 639 M15598 GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 26/82 Gene Ontology BP GO:0050994 0.000418377238126427 0.00423208173555773 910 1076.36363636364 910 3.80415293391833e-05 60 1.38408849437578 1.38408849437578 1 12.4695401004269 360 1732 907 1539 1296 910 492 60 1959 2474 111 640 M13218 GO_GALACTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. 5/16 Gene Ontology BP GO:0006012 0.0376910838843099 0.100286362449771 1115 1485.81818181818 911 0.00383460517648098 6 1.87014341582737 1.87014341582737 1 7.0899384878278 1111 911 4034 248 4399 2072 1694 633 6 440 796 641 M10396 GO_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or around a point. 47/126 Gene Ontology BP GO:0009798 0.00616542002132049 0.0290830863501857 1645 1551.54545454545 912 0.00056206968027482 60 1.41558739034009 1.53848639069916 1 8.25537429422691 1642 60 522 912 778 2473 2232 4264 767 571 2846 642 M15808 GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. 11/49 Gene Ontology BP GO:0045721 0.00469062999042172 0.0240913662008054 915 1020.45454545455 915 0.000427332805302449 247 1.5186173000057 1.5186173000057 1 9.32762943368184 915 896 1218 1393 247 1084 840 491 1991 1815 335 643 M10306 GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING.html Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. 18/62 Gene Ontology BP GO:0010955 0.00980142253522999 0.0398843162410805 430 1242.09090909091 916 0.000895033097798671 220 0.847808867288674 0.847808867288674 1 4.50281718003221 427 1790 1373 2005 916 239 220 311 2942 2999 441 644 M11450 GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 390/1070 Gene Ontology BP GO:0051960 2.93655899075908e-07 1.23949485400858e-05 920 1070.36363636364 916 2.66959943884629e-08 107 1.48045513125749 1.55180252263046 1 27.5738163306978 792 916 107 410 1371 3206 1452 859 920 158 1583 645 M13026 GO_RESPONSE_TO_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 482/1432 Gene Ontology BP GO:0009725 9.0404554434802e-16 5.48149290924023e-13 730 908.181818181818 917 8.21859585770928e-17 7 1.39705292521021 1.45419160173368 1 65.0203892455599 727 461 7 174 1191 2500 1211 1515 917 90 1197 646 M16220 GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. 18/62 Gene Ontology BP GO:1903318 0.00898136823915257 0.0376350773831462 430 1373 917 0.000819840461496612 221 0.847808867288674 0.847808867288674 1 4.58394440535141 428 1791 1374 2006 917 240 221 297 2943 4444 442 647 M16857 GO_REGULATION_OF_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. 325/834 Gene Ontology BP GO:0022604 6.83436991953652e-07 2.45984337491535e-05 985 1226.18181818182 917 6.21306549332379e-08 126 1.35681474780059 1.49226183235345 1 23.7379502243186 981 917 126 652 1477 3981 1988 606 851 194 1715 648 M13993 GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. 98/268 Gene Ontology BP GO:0048738 2.33325990461253e-07 1.05177919777825e-05 920 1264.18181818182 920 2.12114559279249e-08 92 1.65943160759975 1.5427671807198 1 31.3565346862577 920 695 101 677 1369 3033 2034 2174 596 92 2215 649 M12588 GO_REGULATION_OF_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESODERM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of mesoderm development. 10/28 Gene Ontology BP GO:2000380 0.00180244433227085 0.0119553557639051 2190 1280.72727272727 923 0.000163992978011203 131 1.87217356746946 -1.38975139692581 -1 13.661725936855 2188 1802 923 441 131 926 394 4211 1731 723 618 650 M16715 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 14/21 Gene Ontology BP GO:0010664 0.0269134006861888 0.0802196056244435 925 1112.63636363636 924 0.00247712669814886 196 2.03139865611857 2.03139865611857 1 8.4489311986498 1330 1972 1546 923 3037 629 255 1054 196 924 373 651 M16776 GO_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ASSEMBLY.html Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 14/40 Gene Ontology BP GO:0030032 0.00366495398108516 0.0201377293895602 4110 1855.90909090909 925 0.000333733969266153 106 1.36954800204797 1.6722414479866 1 8.81673218164822 4107 419 2003 535 208 4549 2766 550 106 925 4247 652 M10650 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. 15/55 Gene Ontology BP GO:0032731 0.00409316207695631 0.0217942104625093 1540 964.181818181818 928 0.000372799765089279 200 1.49867453025741 1.49867453025741 1 9.45271197525228 1537 889 1311 1507 676 928 580 200 1715 956 307 653 M16162 GO_ACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase (MAPK). 78/224 Gene Ontology BP GO:0000187 0.00175648078680111 0.0117851738339849 140 1097.45454545455 931 0.000159807702837627 40 1.20883941602065 1.20883941602065 1 8.84977887182573 136 1084 1917 931 3820 40 59 485 1840 1657 103 654 M11734 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 31/88 Gene Ontology BP GO:0001837 0.00729550791171809 0.0325077190346517 1500 831.818181818182 932 0.000665437614033413 224 1.31464026095227 1.40443456757271 1 7.42542013965989 1115 948 544 224 1497 1218 421 1497 445 309 932 655 M13477 GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of osteoblast proliferation. 23/49 Gene Ontology BP GO:0033688 0.0122178851311246 0.0467278753408661 445 1017.54545454545 932 0.0011169336796378 193 2.24458518468169 2.24458518468169 1 11.3353094962624 441 1027 2057 932 1267 288 626 1564 405 2393 193 656 M12477 GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 53/128 Gene Ontology BP GO:0071300 8.17972464849376e-06 0.000198840112790348 225 752.363636363636 933 7.43614096484705e-07 48 1.51485880748569 1.51485880748569 1 21.2841676776247 224 48 176 96 1126 1879 1209 933 1379 151 1055 657 M15789 GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cell differentiation. 460/1237 Gene Ontology BP GO:0045597 1.39115718639579e-09 1.31819241151748e-07 735 1014.81818181818 933 1.26468835206862e-10 36 1.43967725485873 1.48627319410217 1 37.5977755117734 734 1065 49 533 1738 2888 1520 362 933 36 1305 658 M12867 GO_OVULATION_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE_PROCESS.html A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 48/121 Gene Ontology BP GO:0022602 0.0213316426482904 0.068541741741185 2565 1740.18181818182 934 0.00195830277974527 605 1.77722238276555 1.90637937804547 1 7.85269489977844 2564 706 885 691 605 3660 2744 2472 672 934 3209 659 M10107 GO_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 258/813 Gene Ontology BP GO:0050865 4.8860753672599e-07 1.84439414066567e-05 395 886.909090909091 935 4.44188768402718e-08 120 1.31543836179163 1.35788298591216 1 23.6384723051227 395 1072 120 727 1280 1657 829 935 1065 306 1370 660 M14224 GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. 39/74 Gene Ontology BP GO:0007044 0.000638712351582856 0.00599099282504889 805 1247.36363636364 936 5.80816236711342e-05 79 1.8852765158377 1.8852765158377 1 15.9046564684446 805 2099 369 1205 4385 1240 1275 79 592 736 936 661 M12750 GO_ATP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. 20/46 Gene Ontology BP GO:0006754 0.0465829822057772 0.116595572173274 940 1416.45454545455 938 0.00432723648654109 374 0.291194063377671 -0.263882050563478 -1 1.03161907177298 842 806 3398 1448 938 374 782 1873 616 3566 938 662 M14214 GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. 37/71 Gene Ontology BP GO:0043124 0.00251804732857315 0.0154442453719486 1165 952.363636363636 938 0.000229175820823566 155 1.18095834059462 1.3149798124598 1 8.11925543525291 1163 1369 2497 950 536 938 621 155 1310 688 249 663 M14911 GO_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of neuron death. 172/401 Gene Ontology BP GO:1901214 0.00935530852617802 0.0386791607186505 985 1143.90909090909 938 0.000854120875076587 368 1.39566586044336 1.53536300950899 1 7.4831457067705 983 2551 874 938 368 1351 776 792 2046 1137 767 664 M15282 GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle development. 68/167 Gene Ontology BP GO:0048634 0.00142884178490278 0.00999113314352954 2270 1477.18181818182 940 0.000129979147682012 39 1.43624646841403 1.49683314937018 1 10.9056071519099 2270 39 569 232 120 3624 3444 2477 940 644 1890 665 M16678 GO_LENS_FIBER_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. 13/29 Gene Ontology BP GO:0070307 0.0742588323989917 0.158445571591463 935 962.545454545455 940 0.00699005512118929 521 1.38989324121763 1.38989324121763 1 4.22127594641078 931 557 1254 978 1159 989 673 940 1698 888 521 666 M10215 GO_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 463/1225 Gene Ontology BP GO:1901698 1.25061966452542e-07 6.17726287488462e-06 715 976 942 1.13692703238054e-08 94 1.26189807495662 1.38885654372951 1 24.9518566860585 712 463 94 272 942 2526 1223 996 1580 528 1400 667 M14661 GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. 26/59 Gene Ontology BP GO:0050775 0.0373729418522213 0.0998403734291504 415 1405.90909090909 943 0.00345666765457479 414 1.61156951470423 1.61156951470423 1 6.12149480090963 414 3499 1829 2806 825 897 511 943 1738 1452 551 668 M11852 GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. 5/16 Gene Ontology BP GO:0048712 0.0064523515652785 0.0298686623305963 585 1642.63636363636 946 0.000647116326302877 133 0.467517394123904 0.491377797631107 1 2.70591029739442 946 581 3816 1223 4255 655 133 745 1779 3354 582 669 M15683 GO_CARDIAC_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. 32/69 Gene Ontology BP GO:0060411 0.0112104433298698 0.0441101679359682 945 985.363636363636 946 0.00102436170611495 529 1.27400634188024 1.34109966161461 1 6.55489802650973 944 712 582 1444 593 1446 529 946 1520 977 1146 670 M13073 GO_ENDODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. 31/73 Gene Ontology BP GO:0035987 0.0109921355950683 0.0435464893924078 340 1406.27272727273 947 0.00100431311379947 337 1.46778240338295 1.46778240338295 1 7.58301618541346 337 2883 579 2761 2438 1120 417 573 2628 947 786 671 M12003 GO_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MOTILITY.html Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. 429/1223 Gene Ontology BP GO:0048870 4.98044801987271e-12 1.217064218751e-09 540 1009.09090909091 948 4.52768001807634e-13 18 1.42098677453912 1.4611266285564 1 48.0843048957801 538 851 18 721 1706 2437 1396 948 1012 152 1321 672 M10259 GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING.html The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. 301/794 Gene Ontology BP GO:0009792 3.98081655126498e-05 0.000702773051236628 1165 1272 949 3.61898962223208e-06 220 1.39251138707088 1.41367636854772 1 16.6669228275927 1164 471 220 623 665 3875 2511 1020 949 245 2249 673 M12439 GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 21/63 Gene Ontology BP GO:0010464 0.0197817404978239 0.0656231205412982 3515 1900.54545454545 951 0.00181471671018991 275 1.57264941793029 1.66409842843252 1 7.06159836409664 3514 275 951 292 582 3929 1762 3900 475 666 4560 674 M13423 GO_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. 796/2245 Gene Ontology BP GO:0045595 2.27243530001187e-05 0.000471000118176509 800 1395.36363636364 951 2.27245853817619e-06 18 1.43094012905259 1.48559124344329 1 18.0708571034723 799 325 4073 242 1454 3340 1614 616 951 18 1917 675 M11136 GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of smooth muscle contraction. 34/84 Gene Ontology BP GO:0006940 0.00488974457044861 0.0247850262451887 140 913.363636363636 952 0.000445513319049111 88 1.42249315451495 1.42249315451495 1 8.67065170307428 139 1582 952 1462 2811 88 103 1241 447 1030 192 676 M14332 GO_MECHANORECEPTOR_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANORECEPTOR_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. 25/96 Gene Ontology BP GO:0042490 0.0480531719476509 0.119119528752239 590 1286.90909090909 952 0.00446691159851043 559 1.63611132979598 1.63611132979598 1 5.73852212252736 588 952 1116 1359 4477 1614 618 679 559 1384 810 677 M13149 GO_HEPATOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a hepatocyte, the main structural component of the liver. 9/17 Gene Ontology BP GO:0097284 0.0765897756730953 0.158445571591463 955 1531.36363636364 953 0.00793650793650794 25 1.79661288551867 1.79661288551867 1 5.45653330329135 953 899 4022 132 3723 2135 2300 1322 25 678 656 678 M15768 GO_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. 31/92 Gene Ontology BP GO:0048709 0.0839184282471183 0.158445571591463 945 1301.45454545455 953 0.00793650793650794 612 1.30886634746469 1.30886634746469 1 3.97518734947194 945 624 1620 880 1681 2955 1947 1162 612 953 937 679 M10944 GO_PEPTIDE_CROSS_LINKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CROSS_LINKING.html The formation of a covalent cross-link between or within protein chains. 22/103 Gene Ontology BP GO:0018149 0.000682097561150145 0.00633395795284025 780 1234.90909090909 954 6.20281030439645e-05 345 1.46778240338295 1.46778240338295 1 12.2478757503652 776 954 345 1306 891 2832 603 1529 1986 695 1667 680 M14602 GO_DETECTION_OF_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_STIMULUS.html The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. 150/1291 Gene Ontology BP GO:0051606 0.00424358444356543 0.0223136608963469 700 1291.81818181818 957 0.00038652655228578 255 1.3508243284727 1.3508243284727 1 8.46771157152908 699 3560 480 3042 1483 1652 957 592 1121 255 369 681 M16902 GO_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a synapse. 39/123 Gene Ontology BP GO:0007416 0.0839184282471183 0.158445571591463 600 1143.36363636364 957 0.00793650793650794 517 1.50259746579649 1.49422076735705 1 4.56357247551453 596 517 957 772 2473 1268 762 1488 676 1163 1905 682 M11868 GO_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH.html Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. 363/998 Gene Ontology BP GO:0040008 7.47147109182453e-05 0.0011336614470373 810 1001.09090909091 958 6.79247713114032e-06 119 1.33635871946179 1.35286229311257 1 14.9414161066786 809 990 249 119 1599 2432 1325 1794 958 137 600 683 M14080 GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/58 Gene Ontology BP GO:0010828 0.0643817515963309 0.1466034686914 615 1125.81818181818 959 0.006031531383673 537 1.28011859969869 1.28011859969869 1 4.05180343964925 611 537 1889 611 1087 2046 935 797 1682 1230 959 684 M11092 GO_WHITE_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_WHITE_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. 12/20 Gene Ontology BP GO:0050872 0.00310024391979622 0.0178881977064173 1000 1039.72727272727 960 0.000282238311618066 80 0.816391131298516 -0.816391131298516 -1 5.41509581102531 996 133 2086 960 1015 254 80 1560 843 3163 347 685 M11606 GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 237/649 Gene Ontology BP GO:0051962 0.00678519179574675 0.0309164982364579 835 1234.18181818182 960 0.000618746303853784 535 1.50073916597898 1.55000573550313 1 8.60071704038934 831 2238 535 1172 2044 2369 814 743 960 685 1185 686 M12488 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. 18/44 Gene Ontology BP GO:1904036 0.0224752634989537 0.071424365251083 915 1093.18181818182 960 0.00206438273024504 452 1.46528721629209 1.46528721629209 1 6.37489180882622 912 2213 1545 1100 960 587 746 476 1970 1064 452 687 M12822 GO_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 107/316 Gene Ontology BP GO:1901654 2.29795412027974e-07 1.04601970396655e-05 1040 1092 960 2.08904941846067e-08 100 1.22188964779837 1.27764698404468 1 23.0998247261423 1039 355 100 252 333 2679 960 1940 1537 459 2358 688 M16343 GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 18/55 Gene Ontology BP GO:0010862 0.00695417141433154 0.0313486294765926 4380 1834.63636363636 960 0.000634204657585792 283 1.43433414636607 -1.79325614046967 -1 8.18732988374028 4377 960 623 325 313 4308 4389 2377 294 283 1932 689 M13610 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. 118/249 Gene Ontology BP GO:0048872 0.0224902911904121 0.071424365251083 965 1413.18181818182 961 0.00206577741928012 477 1.4620584416425 1.4620584416425 1 6.36084467264846 961 3230 2463 933 1615 2213 1428 477 814 553 858 690 M13485 GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. 190/457 Gene Ontology BP GO:0071902 0.0186965748701015 0.0632251981951067 215 933.727272727273 963 0.0017143075637522 215 1.44821737298018 1.44821737298018 1 6.5917379910978 215 1078 963 648 2973 361 265 1071 1022 1438 237 691 M10536 GO_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CHEMOTAXIS.html The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). 82/236 Gene Ontology BP GO:0060326 3.94378188139498e-07 1.5650409637023e-05 265 1004.45454545455 964 3.5852568985169e-08 114 1.5225443785241 1.5225443785241 1 27.7724024070203 263 2091 114 964 791 1468 1119 1394 688 842 1315 692 M11366 GO_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_ASSEMBLY.html The aggregation, arrangement and bonding together of the extracellular matrix. 14/22 Gene Ontology BP GO:0085029 0.00139592328367796 0.00983501032794652 1105 845.909090909091 964 0.000126982709034567 117 1.41068923157703 1.60068730128457 1 10.7481737549039 1102 964 639 314 117 1891 1440 975 298 444 1121 693 M10268 GO_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 497/1356 Gene Ontology BP GO:0060429 1.83561138297472e-11 3.15657172264875e-09 665 1000.63636363636 965 1.66873762090003e-12 27 1.29809941179845 1.3670273327415 1 41.886510612258 665 680 27 849 1565 2115 1448 965 1047 204 1442 694 M11818 GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrate derivative. 518/1241 Gene Ontology BP GO:1901135 0.011126930250754 0.0439679465142559 4495 1872.72727272727 966 0.00111830399240002 306 1.29938442802694 1.48490394879945 1 6.69238859491121 4493 332 3812 306 445 621 4388 2464 966 314 2459 695 M15138 GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. 20/55 Gene Ontology BP GO:0002053 0.00109945016496701 0.00830040181453953 4365 2016.36363636364 968 1e-04 94 1.57264941793029 1.66409842843252 1 12.4219719480879 4365 543 968 94 915 4031 2772 3510 489 638 3855 696 M10249 GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT.html The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. 80/195 Gene Ontology BP GO:0061008 0.00109945016496701 0.00830040181453953 2920 1764 969 1e-04 51 1.24256861352086 1.3289494957695 1 9.81474464981899 2920 366 751 51 969 3277 3294 2797 553 546 3880 697 M11678 GO_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a leukocyte. 84/448 Gene Ontology BP GO:0002443 0.0204122464601491 0.0668023830199863 445 1127.18181818182 969 0.00187310313707184 252 1.11747994513129 1.14812710889005 1 4.98496053677128 445 1828 1206 1553 792 519 350 969 2081 2404 252 698 M16144 GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 75/173 Gene Ontology BP GO:0010811 1.60056415070205e-05 0.000353877111986173 410 1029.72727272727 970 1.45506890490143e-06 189 1.42247984743363 1.4266437936826 1 18.6344628239479 410 1312 189 970 2262 1608 647 579 1398 488 1464 699 M16206 GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels. 458/1179 Gene Ontology BP GO:0072358 1.94675659197525e-13 7.53232571378425e-11 370 954.181818181818 970 1.76977871997766e-14 11 1.48058828008815 1.50675704303907 1 56.8923426873781 367 682 11 323 1200 2351 1348 1344 970 33 1867 700 M16442 GO_CIRCULATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. 458/1179 Gene Ontology BP GO:0072359 1.94675659197525e-13 7.53232571378425e-11 370 960.454545454545 971 1.76977871997766e-14 12 1.48058828008815 1.50675704303907 1 56.8923426873781 368 683 12 324 1201 2352 1349 1403 971 34 1868 701 M14196 GO_SEGMENT_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENT_SPECIFICATION.html The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. 14/24 Gene Ontology BP GO:0007379 0.03148945812331 0.0892373442861315 975 1054.63636363636 972 0.00290449299742655 280 1.36684426975596 -0.9282856402567 -1 5.44489376909484 972 413 896 1066 1338 612 280 707 2206 2027 1084 702 M16048 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 18/29 Gene Ontology BP GO:0010662 0.00581358211241879 0.0278272801525365 980 1173.27272727273 979 0.000529909254209474 116 2.03139865611857 2.03139865611857 1 11.9944564227819 979 2112 1708 1302 3611 527 116 812 290 1073 376 703 M10700 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 992/2850 Gene Ontology BP GO:0048584 0.0765897756730953 0.158445571591463 845 1292.09090909091 980 0.00793650793650794 437 1.33745360849254 1.40147651769942 1 4.06201036132425 638 844 3622 807 1285 2454 980 842 1166 437 1138 704 M16363 GO_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of JUN kinase activity. 56/166 Gene Ontology BP GO:0043506 0.0532580180300162 0.128342097265405 805 1161.63636363636 980 0.00496297818178455 617 1.71146074014946 1.71146074014946 1 5.79240963766519 802 1427 980 758 1732 1696 1483 706 617 1752 825 705 M12163 GO_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 765/2167 Gene Ontology BP GO:0009719 6.60961037253947e-06 0.000163236281700536 720 1202 982 6.60963003174893e-07 13 1.3807188557804 1.45333029652671 1 19.8485512569827 717 589 3861 171 805 2266 1097 1519 982 13 1202 706 M10162 GO_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCRETION.html The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. 23/63 Gene Ontology BP GO:0007588 0.00399586501017883 0.0214731495859494 340 1278.36363636364 983 0.000363921928885583 97 1.53960170275972 1.53960170275972 1 9.74852259895894 340 272 1038 983 3417 454 508 1917 2650 2386 97 707 M15758 GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY.html Any process that initiates the activity of an inactive protein kinase. 166/415 Gene Ontology BP GO:0032147 0.0839184282471183 0.158445571591463 490 1116.18181818182 983 0.00793650793650794 488 1.43664025592302 1.43664025592302 1 4.36325235358989 488 1919 1087 930 2179 924 768 1351 983 1061 588 708 M10127 GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION.html Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. 14/22 Gene Ontology BP GO:0051900 0.0839184282471183 0.158445571591463 2410 1541.27272727273 985 0.00793650793650794 385 2.24458518468169 2.24458518468169 1 6.81708002379904 2409 890 985 911 2460 3650 1595 866 385 2006 797 709 M10485 GO_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLERANCE_INDUCTION.html A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. 5/14 Gene Ontology BP GO:0002507 0.000999550119979004 0.00804317366908581 2250 1260.36363636364 985 1e-04 33 1.29958242735532 1.29958242735532 1 10.332525120929 2246 161 3597 33 216 2943 2043 985 95 438 1107 710 M13921 GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. 33/112 Gene Ontology BP GO:0031644 0.000769201393779477 0.0068286846487918 170 1034.72727272727 985 6.99518606148409e-05 170 1.38364714832877 1.38364714832877 1 11.3742677856006 170 1478 353 1707 1257 734 446 1091 985 2591 570 711 M10591 GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. 121/338 Gene Ontology BP GO:0070302 0.0257487195583714 0.0784268537777523 755 997.818181818182 986 0.00236864672595343 285 1.51445638411053 1.51445638411053 1 6.3553076535029 755 1002 996 1189 1122 936 634 982 986 2089 285 712 M14757 GO_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLATION.html The covalent attachment of a fucosyl group to an acceptor molecule. 9/29 Gene Ontology BP GO:0036065 0.000754326324688851 0.00673526370294295 315 1741.72727272727 986 7.54582500774735e-05 81 0.715858725339802 0.715858725339802 1 5.90097079683476 313 3070 4288 2295 81 322 763 986 2364 4092 585 713 M15423 GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 113/230 Gene Ontology BP GO:0006888 0.0048980903704746 0.0247950740359018 2405 1204.63636363636 986 0.000446275419494961 19 1.22803400724614 1.36501566437336 1 7.48452667239345 2403 19 2462 247 253 83 1455 3774 479 986 1090 714 M13812 GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. 15/36 Gene Ontology BP GO:0002437 0.0439132034670273 0.112051654492429 675 1401.18181818182 987 0.00407409451232319 501 0.605982337417866 0.7335155144394 1 2.18653613221287 672 1391 987 2340 909 569 501 1289 2222 3838 695 715 M11071 GO_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH.html Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). 653/1569 Gene Ontology BP GO:0008219 0.0178287886679588 0.0612724395154204 650 1259.90909090909 988 0.00179734645478326 244 1.48844989364688 1.59916707714313 1 6.85184138135899 800 1259 3683 988 647 2257 1242 951 1142 646 244 716 M12799 GO_NEPHRON_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. 44/140 Gene Ontology BP GO:0072009 0.000211191592808439 0.00253375339899117 2075 1488.90909090909 988 1.92010790108518e-05 286 1.52594545084974 1.69990912707203 1 15.0380093309177 2073 513 286 725 988 2893 1923 3495 556 305 2621 717 M12878 GO_ORGANIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. 472/1183 Gene Ontology BP GO:0006082 0.000404526388051722 0.00412794729609702 4450 1755.27272727273 988 3.67818899772892e-05 323 1.21765228478273 1.35787114706348 1 11.0200914522821 4450 335 323 578 872 548 4129 3127 1544 988 2414 718 M13035 GO_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_GROWTH.html Any process that modulates the frequency, rate, extent or direction of cell growth. 238/558 Gene Ontology BP GO:0001558 0.000295825285453345 0.00324708463442053 310 1166.45454545455 988 2.68968246725157e-05 205 1.36884183715419 1.38913029420464 1 12.9300219477042 1053 920 308 205 2284 2986 1485 1341 988 308 953 719 M15104 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION.html The process in which epiblast cells acquire specialized features of neuroepithelial cells. 33/104 Gene Ontology BP GO:0060563 0.00419658030586423 0.0222428337444379 1625 1354.72727272727 989 0.000382236989050469 478 1.7084174903023 1.78822979351741 1 10.7182563874422 1625 1930 478 871 3888 2038 1077 911 500 595 989 720 M15972 GO_MATERNAL_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PLACENTA_DEVELOPMENT.html Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 16/41 Gene Ontology BP GO:0001893 0.0142294170516662 0.0526380793457477 640 1303.36363636364 989 0.00130202671282756 257 1.91509024629137 1.91509024629137 1 9.29533677150324 640 2024 619 989 3444 303 337 1265 2338 2121 257 721 M13010 GO_LEUKOCYTE_TETHERING_OR_ROLLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_TETHERING_OR_ROLLING.html Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). 10/17 Gene Ontology BP GO:0050901 0.00100899782892192 0.00808781937438975 840 1484.45454545455 992 9.1769171670388e-05 41 1.89858521402465 1.89858521402465 1 15.0776617470732 840 2574 992 1296 4580 631 41 274 2930 1695 476 722 M13078 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of multicellular organismal development. 850/2329 Gene Ontology BP GO:2000026 3.39681659013806e-05 0.000622658752658488 620 1153.09090909091 992 3.39686851388837e-06 21 1.48147568119976 1.54670896494437 1 18.0273294540917 619 172 4007 179 1286 2695 1234 464 1015 21 992 723 M14170 GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL.html The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. 10/17 Gene Ontology BP GO:0061756 0.00100899782892192 0.00808781937438975 845 1486.81818181818 993 9.1769171670388e-05 42 1.89858521402465 1.89858521402465 1 15.0776617470732 841 2575 993 1297 4581 632 42 284 2931 1702 477 724 M14503 GO_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 258/735 Gene Ontology BP GO:0042493 1.51882925501533e-09 1.41038484620724e-07 695 986.454545454545 993 1.380753869149e-10 50 1.46688385144418 1.56028323696415 1 38.144815848626 691 475 50 250 1079 2745 1355 1178 993 518 1517 725 M14800 GO_HISTONE_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). 7/14 Gene Ontology BP GO:0071044 0.00845997812675798 0.0362693245083447 495 1850.63636363636 993 0.000849235881061886 280 0.237295579326956 -0.237295579326956 -1 1.29747274043248 993 2690 4294 3205 859 280 493 302 2651 4099 491 726 M16228 GO_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 461/1233 Gene Ontology BP GO:0060284 4.23841595169405e-07 1.63991377197629e-05 1105 1344.63636363636 994 3.85310615295222e-08 117 1.42968187302444 1.4855129595179 1 25.9683782762339 1104 914 117 663 1659 4154 2175 574 994 273 2164 727 M14458 GO_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DIFFERENTIATION.html The establishment of the sex of an organism by physical differentiation. 164/438 Gene Ontology BP GO:0007548 0.00596223183363325 0.0283053603308376 3135 1930.45454545455 997 0.000543495607651211 275 1.56017538985421 1.74858966063781 1 9.16829225672517 3135 997 618 553 275 3339 2746 3782 782 455 4553 728 M14917 GO_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEATH.html Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 854/2183 Gene Ontology BP GO:0010941 0.000757904218240221 0.00675422127694692 905 1178.81818181818 998 7.58162830846265e-05 68 1.3785005403078 1.45421641450534 1 11.3568763666333 901 324 4316 108 542 2411 1237 1017 998 68 1045 729 M10474 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE.html Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. 8/21 Gene Ontology BP GO:0090178 0.0765897756730953 0.158445571591463 1210 1359.45454545455 999 0.00793650793650794 189 1.91021908880517 1.91021908880517 1 5.80156925216492 1206 1664 3593 743 3007 1156 999 899 189 616 882 730 M11976 GO_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE.html Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. 590/1913 Gene Ontology BP GO:0006952 0.046162535692411 0.115860574033061 830 1451 1000 0.00471504858246232 319 1.44545676875958 1.56630346523832 1 5.13591741460119 828 755 3836 649 1640 2911 1253 1000 987 319 1783 731 M11069 GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of epithelial cell migration. 117/251 Gene Ontology BP GO:0010632 0.00696786250696609 0.0313486294765926 795 1307.72727272727 1003 0.000635457231419448 539 1.48154484938067 1.48154484938067 1 8.45681353272921 793 1003 539 888 1600 2588 1606 971 1501 764 2132 732 M15788 GO_SNRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_PROCESSING.html Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. 14/23 Gene Ontology BP GO:0016180 0.0120651953633717 0.0462200512146326 1015 1387.63636363636 1004 0.00110289778081839 441 0.34551429924062 -0.325677203319537 -1 1.75109490647121 1012 651 3189 1427 441 521 1010 1004 730 4352 927 733 M10860 GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. 19/40 Gene Ontology BP GO:0035872 0.000303576538055823 0.00330869921641593 1005 1449.45454545455 1005 2.76016760431772e-05 20 1.06710845596515 1.06710845596515 1 10.0467936931599 1005 1596 3061 1562 4595 216 20 937 381 2235 336 734 M15641 GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 81/250 Gene Ontology BP GO:0050777 0.00353900349993958 0.0196550158495448 1005 1170.54545454545 1005 0.000322246302681116 185 1.2920776236824 1.2920776236824 1 8.36968087041767 335 1005 648 1471 2942 1976 1155 185 1003 827 1329 735 M11931 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. 38/109 Gene Ontology BP GO:0034121 0.00166499415472536 0.0113164401450947 405 1317.90909090909 1006 0.000151477780444625 128 1.45031648725338 1.45031648725338 1 10.7146405025034 401 1685 1919 1227 4560 708 924 128 808 1131 1006 736 M16921 GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 204/508 Gene Ontology BP GO:0031346 0.0404524572640988 0.105799878598956 600 1201.72727272727 1006 0.0037469095930034 597 1.37806236823722 1.51152093627471 1 5.10281684661186 597 2332 853 1373 2069 1587 1109 627 1006 785 881 737 M16576 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 100/279 Gene Ontology BP GO:0007178 0.000830020468569372 0.00713663895475481 760 1039 1007 7.54848896257042e-05 176 1.39866823237189 1.32692497635411 1 11.3960436543986 760 1469 360 1007 488 2079 1297 922 1477 176 1394 738 M15441 GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 34/82 Gene Ontology BP GO:0051785 0.0131538605715373 0.0497227481741481 2335 1294.81818181818 1008 0.0012030156870417 342 1.67731446454531 1.88779060241808 1 8.29878268951249 2334 1639 596 1008 579 2855 726 1476 471 342 2217 739 M15451 GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 274/721 Gene Ontology BP GO:0010720 5.18027176118301e-05 0.000862138915575992 655 1107.54545454545 1008 4.7094488576878e-06 229 1.40786494436847 1.45974499172253 1 16.3763421813003 653 1354 229 969 1841 2538 1245 269 1784 293 1008 740 M11987 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. 23/58 Gene Ontology BP GO:0032715 0.00404051862672711 0.0216130506726889 550 1178.54545454545 1009 0.000367996234331773 199 1.42883632695421 1.42883632695421 1 9.03187680166663 550 1483 1556 1009 2614 1317 965 199 1942 709 620 741 M15370 GO_NEURAL_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_FORMATION.html The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. 64/142 Gene Ontology BP GO:0001841 0.0371636343573008 0.0993955958069975 690 1237.18181818182 1009 0.00343697123448045 501 1.42278250583757 1.42278250583757 1 5.41486559181871 686 1009 2570 798 1675 1864 1713 600 501 1286 907 742 M15116 GO_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 44/111 Gene Ontology BP GO:0034332 0.0263937394555216 0.0794206949397192 1010 1363.27272727273 1010 0.00242871017437015 461 1.8852765158377 1.8852765158377 1 7.87229130049977 1010 1891 967 821 2378 2395 2333 502 461 840 1398 743 M16246 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. 16/42 Gene Ontology BP GO:1901381 0.115184272563192 0.205054048682587 1530 1271 1011 0.0110634245399517 440 1.28127221255727 -1.28127221255727 -1 3.34672611628644 1527 963 2221 1212 2485 440 767 952 1497 1011 906 744 M10510 GO_CORONARY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORONARY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. 27/93 Gene Ontology BP GO:0060976 0.0839184282471183 0.158445571591463 635 1134.27272727273 1013 0.00793650793650794 633 1.87224225630062 1.87224225630062 1 5.686228962116 633 636 873 1013 2043 1593 1391 1186 646 833 1630 745 M13227 GO_LOCALIZATION_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_OF_CELL.html Any process in which a cell is transported to, and/or maintained in, a specific location. 429/1223 Gene Ontology BP GO:0051674 4.98044801987271e-12 1.217064218751e-09 540 1032.36363636364 1013 4.52768001807634e-13 19 1.42098677453912 1.4611266285564 1 48.0843048957801 539 852 19 722 1707 2438 1397 1194 1013 153 1322 746 M13454 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. 93/259 Gene Ontology BP GO:0031348 0.0053424218833445 0.0262207873196285 2750 1820.72727272727 1014 0.000486858141596248 267 1.25975053381343 1.28825529004063 1 7.56172637788186 2748 602 953 1160 267 3024 4401 979 973 1014 3907 747 M15978 GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. 6/24 Gene Ontology BP GO:0010640 0.015149658954305 0.0545693301201226 780 1439.63636363636 1014 0.00152539413974189 207 1.72827849287814 1.72827849287814 1 8.28594361051894 780 1748 4490 885 2100 1014 207 623 1920 1341 728 748 M16208 GO_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 56/135 Gene Ontology BP GO:0006970 0.0277123082643079 0.0814871736992916 930 1099.81818181818 1015 0.0025516063010775 411 1.17973645741602 1.25221321949766 1 4.87623373825663 930 1832 1340 1015 1054 817 842 521 1585 1751 411 749 M15018 GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 33/83 Gene Ontology BP GO:0050810 0.129274241468441 0.224970128612433 690 1161.45454545455 1018 0.0125055304877016 257 1.14862337182928 1.00672811381994 1 2.82472515807493 1096 257 977 689 2291 690 1165 2444 1400 1018 749 750 M10479 GO_VENTRICULAR_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_MORPHOGENESIS.html The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. 22/43 Gene Ontology BP GO:0060412 0.0165028775926003 0.0578285740848628 1020 1135.81818181818 1019 0.00151163514751441 429 1.27400634188024 1.34109966161461 1 5.98617596639158 1019 721 658 1213 527 1553 429 1925 1974 694 1781 751 M16371 GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 833/2142 Gene Ontology BP GO:0051174 0.0472802801775882 0.117895994019625 705 1386.54545454545 1019 0.00483174156021222 405 1.35002098718154 1.43302975356383 1 4.75806208095816 705 1562 4554 773 1019 2447 905 698 1158 405 1026 752 M14572 GO_PERICARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. 13/30 Gene Ontology BP GO:0060039 0.0063749185617649 0.029628375257532 1085 1011.27272727273 1020 0.000581224217192366 122 1.49422076735705 1.49422076735705 1 8.66818926665259 1085 122 1381 383 3227 1496 1049 254 224 883 1020 753 M12755 GO_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE.html An immune response mediated through a body fluid. 76/484 Gene Ontology BP GO:0006959 3.60665555482344e-07 1.46888144061281e-05 4365 1999.27272727273 1022 3.27877831463153e-08 111 1.42140993018184 1.64603555538543 1 26.0762155665678 4361 770 111 1022 554 2740 3947 2996 760 744 3987 754 M12009 GO_DECIDUALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DECIDUALIZATION.html The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. 12/25 Gene Ontology BP GO:0046697 0.00234874646200816 0.0146471578788332 495 1321.09090909091 1023 0.000213750706029344 433 1.91509024629137 1.91509024629137 1 13.3338083004673 494 1660 433 810 2804 589 628 1895 2332 1864 1023 755 M12406 GO_COMPLEMENT_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION.html Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. 16/240 Gene Ontology BP GO:0006956 0.00496327424043744 0.0249669364012471 700 1319.72727272727 1024 0.000452227913535978 498 1.23608342732844 1.37200307782393 1 7.51951047661781 696 553 498 1024 2769 1590 682 1844 2520 1002 1339 756 M11353 GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cell junction assembly. 66/135 Gene Ontology BP GO:1901888 0.000371782490276403 0.00390539842161389 155 916.909090909091 1025 3.38041212206135e-05 148 1.31978529899385 1.31284700114904 1 12.0650007248485 153 1088 317 445 2132 1761 1157 422 1438 148 1025 757 M11981 GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. 459/1152 Gene Ontology BP GO:0051345 4.16085847791795e-05 0.000725545224079102 1175 1261.54545454545 1027 3.78267015844482e-06 221 1.43266274112924 1.54899935680804 1 17.0721780062117 1173 464 221 460 834 3751 1868 1175 1027 325 2579 758 M12873 GO_CEREBRAL_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_DEVELOPMENT.html The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. 65/190 Gene Ontology BP GO:0021987 0.00848376854633239 0.0363377650928241 750 1266.18181818182 1027 0.000774241988282853 233 1.52514364032306 1.52514364032306 1 8.33436321266413 747 1888 555 1380 1027 3200 1771 991 1748 233 388 759 M15467 GO_NEGATIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSSIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation. 42/94 Gene Ontology BP GO:0030279 0.0839184282471183 0.158445571591463 1030 1286 1027 0.00793650793650794 351 1.23365881767865 1.23365881767865 1 3.74677287340041 1027 781 924 704 1318 1833 1343 3015 351 2129 721 760 M10081 GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION.html The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. 22/66 Gene Ontology BP GO:0060395 0.00109945016496701 0.00830040181453953 4160 1705.63636363636 1028 1e-04 49 1.53661608224214 1.31656781498502 1 12.1373534692221 4160 1028 881 49 224 3056 3442 2199 147 351 3225 761 M16787 GO_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). 53/155 Gene Ontology BP GO:0003014 0.000529669808657953 0.00511033915617286 1030 976.363636363636 1028 4.81633976757477e-05 323 1.48150013033627 1.61921930777429 1 12.8865990178387 323 937 337 1121 1486 1002 771 1140 1565 1028 1030 762 M13898 GO_NEGATIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEATH.html Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 527/1365 Gene Ontology BP GO:0060548 0.0240241790905406 0.0747615707221044 330 1205.72727272727 1029 0.00242879235272133 210 1.41027982650039 1.48420491512199 1 6.02941158163594 1099 330 4152 210 679 2231 1200 947 1029 327 1059 763 M14307 GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. 49/122 Gene Ontology BP GO:0006081 0.0336014793229576 0.0932003951166524 1885 1307.27272727273 1032 0.00310235794401537 192 0.887014101864255 -0.919061814017297 -1 3.46992759048422 1882 243 2055 852 1002 192 2270 1032 1998 2315 539 764 M16798 GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. 37/83 Gene Ontology BP GO:0007266 0.0614999366623025 0.141709283336511 955 1285.27272727273 1033 0.00575359842192228 543 1.39367575003002 1.39367575003002 1 4.48924048701224 951 1019 816 1788 2987 1768 1150 1033 1394 689 543 765 M12904 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune system process. 447/1372 Gene Ontology BP GO:0002684 3.56833791921383e-08 2.02046255596461e-06 550 1149.72727272727 1034 3.2439436155375e-09 82 1.28428201892286 1.35189537688649 1 27.7604807088706 549 1672 82 914 1340 2349 933 1034 1216 989 1569 766 M10826 GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 116/257 Gene Ontology BP GO:0046395 0.0164565529324826 0.057709800049484 1135 1264.18181818182 1035 0.00150735971384207 352 0.976924543011338 -0.859642644445426 -1 4.59358830912682 1131 352 1035 761 525 427 2543 1656 1903 2687 886 767 M16711 GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION.html Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. 8/23 Gene Ontology BP GO:0048070 0.00566479805982885 0.027283876962433 1035 1576.81818181818 1035 0.000567929055338353 38 2.24458518468169 2.24458518468169 1 13.3261945807144 1035 2719 4609 1758 3482 916 606 251 38 1537 394 768 M10248 GO_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION.html The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 213/1652 Gene Ontology BP GO:0007600 4.74703510943088e-07 1.80659705025308e-05 345 1022.81818181818 1036 4.31548739429044e-08 119 1.47334741177278 1.51230488696663 1 26.5263942742392 343 1822 119 1999 2133 1329 1036 466 1053 291 660 769 M13128 GO_ORGANIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. 116/257 Gene Ontology BP GO:0016054 0.0164565529324826 0.057709800049484 1135 1273.36363636364 1036 0.00150735971384207 353 0.976924543011338 -0.859642644445426 -1 4.59358830912682 1132 353 1036 762 526 428 2544 1747 1904 2688 887 770 M14915 GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. 52/123 Gene Ontology BP GO:1904029 0.0102054983841046 0.0412753736911131 660 1472.63636363636 1036 0.00093210454999902 175 1.26140381412246 1.26140381412246 1 6.62818175588276 657 4007 1787 3060 1229 1036 192 451 2583 1022 175 771 M11740 GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 169/414 Gene Ontology BP GO:0051961 3.41890544318486e-05 0.000622658752658488 1040 1421.81818181818 1037 3.10814415979098e-06 9 1.33754513389768 1.36391243134968 1 16.2759113055018 1037 9 217 614 862 4318 2494 1604 2035 348 2102 772 M16656 GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. 16/39 Gene Ontology BP GO:0014065 0.0217920081015868 0.0697314222023897 610 1114.90909090909 1038 0.00200099178726014 468 1.39435884473133 1.39435884473133 1 6.12144940921552 610 962 1478 890 1310 1038 1423 468 1688 1012 1385 773 M16525 GO_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GTPASE_ACTIVITY.html Any process that modulates the rate of GTP hydrolysis by a GTPase. 306/772 Gene Ontology BP GO:0043087 0.0363667483372067 0.097771171123133 2475 1978.09090909091 1040 0.00336201763699728 340 1.40900577913641 1.55342568019308 1 5.40070828083339 2472 340 736 720 878 4556 3326 2944 1040 542 4205 774 M14411 GO_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. 17/46 Gene Ontology BP GO:0097581 0.00509665161802787 0.0253630798097571 3275 1588.72727272727 1041 0.00046440884210833 123 1.36954800204797 1.6722414479866 1 8.2958790072143 3272 810 2475 548 262 3311 1756 398 123 1041 3480 775 M10160 GO_CERAMIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. 6/13 Gene Ontology BP GO:0046514 0.048501382329165 0.119828721561994 765 1562 1043 0.00495936603701395 92 2.06322935667965 2.06322935667965 1 7.2164127372844 763 2829 3546 764 4331 1043 658 705 92 1303 1148 776 M12373 GO_GLYCOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 6/13 Gene Ontology BP GO:0019377 0.0478513572206944 0.118890959210725 765 1595.72727272727 1044 0.00489140980153061 93 2.06322935667965 2.06322935667965 1 7.2431351611533 764 2830 3898 765 4332 1044 659 703 93 1316 1149 777 M12194 GO_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. 67/235 Gene Ontology BP GO:0009913 0.0192298175612387 0.0643720569119187 840 1283.36363636364 1045 0.00176363528504009 615 1.4396179502386 1.4396179502386 1 6.50993389731396 836 936 651 1045 2488 1800 1426 1859 1507 615 954 778 M15682 GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS.html The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. 63/167 Gene Ontology BP GO:0060560 0.0355736717559835 0.0964769614270044 1970 1358.63636363636 1045 0.00328747827261338 374 1.59684245424852 1.7016656685628 1 6.15576305034243 1968 774 733 374 1045 2987 2166 1290 651 551 2406 779 M10257 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 144/369 Gene Ontology BP GO:0090287 0.00536560957174832 0.0263044915089772 1550 1481.72727272727 1046 0.000488976426082056 507 1.19788185081951 1.28084496920386 1 7.18406215800619 1548 859 507 784 875 3752 2031 1046 1458 830 2609 780 M11503 GO_KIDNEY_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 68/192 Gene Ontology BP GO:0072073 0.000311103861320327 0.00338279912906388 1915 1525.72727272727 1047 2.82861694083774e-05 260 1.45420952950888 1.55797332071312 1 13.6382426876009 1911 370 309 615 1047 3526 2074 3556 636 260 2479 781 M14177 GO_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 54/179 Gene Ontology BP GO:0070542 0.00660690057128817 0.0304022193780882 835 1134.18181818182 1048 0.000602438710945142 49 1.10176310759822 1.17310610167315 1 6.34465704255182 833 49 593 608 299 2557 1254 1683 2076 1048 1476 782 M10321 GO_REGULATION_OF_COLLATERAL_SPROUTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COLLATERAL_SPROUTING.html Any process that modulates the frequency, rate or extent of collateral sprouting. 16/35 Gene Ontology BP GO:0048670 0.00109945016496701 0.00830040181453953 1535 1336.81818181818 1049 1e-04 54 1.46844125213304 1.46844125213304 1 11.5988572109095 1532 278 1049 54 2669 2021 1556 4107 171 509 759 783 M11702 GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND.html A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. 22/47 Gene Ontology BP GO:0001702 0.0340352288050821 0.0938951677611386 760 1420.63636363636 1049 0.00314304246573301 571 1.79952667700485 1.79952667700485 1 7.0175707896897 759 3385 1410 2195 1049 671 932 571 2488 1264 903 784 M13591 GO_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 58/157 Gene Ontology BP GO:0006633 0.035284478202588 0.0961785994461194 620 1514.36363636364 1050 0.00326031152852399 308 1.14894413261494 1.28609126820956 1 4.43499969244072 617 1632 1050 2366 4046 658 308 584 2240 2479 678 785 M11008 GO_LYMPHOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. 35/71 Gene Ontology BP GO:0002260 0.00635655722836749 0.0295726404922948 1120 1129.45454545455 1051 0.000579545286216007 253 1.86257814601771 1.86257814601771 1 10.8108647248684 1118 2919 1939 1060 714 1426 855 253 486 1051 603 786 M14489 GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 35/109 Gene Ontology BP GO:0010830 0.0760184339440078 0.158445571591463 565 1470.63636363636 1052 0.0071617910576758 428 1.69515102423431 1.69515102423431 1 5.14838120798331 563 2594 1313 2124 4244 1049 428 1239 754 1052 817 787 M15824 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. 14/35 Gene Ontology BP GO:2000352 0.0120115595079178 0.0460816150833625 1675 1234 1052 0.00109796781081395 439 1.46528721629209 1.46528721629209 1 7.43344198463578 1672 2120 1881 1710 439 929 789 1052 1357 923 702 788 M16742 GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus. 9/18 Gene Ontology BP GO:2001275 0.0411933643957287 0.107088908672659 1310 1617.90909090909 1052 0.00419775028277304 434 0.570555481694161 0.665275333208404 1 2.10131533447431 1307 434 4614 692 927 1566 444 924 1258 4579 1052 789 M15954 GO_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 704/2148 Gene Ontology BP GO:0048468 1.6360897609804e-07 7.67309571740606e-06 955 1605.27272727273 1053 1.63608988143595e-08 4 1.47351495224862 1.55591392418757 1 28.6094765033842 955 678 4487 114 1420 4189 2028 1053 867 4 1863 790 M13392 GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. 8/14 Gene Ontology BP GO:2000052 0.00413690213212205 0.0219515846850774 1840 1332.27272727273 1054 0.000414462365214947 241 1.13355020487727 1.45362879893672 1 7.1362885477127 1840 569 4067 661 241 1700 1293 472 2138 620 1054 791 M11957 GO_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING.html The series of events that restore integrity to a damaged tissue, following an injury. 278/666 Gene Ontology BP GO:0042060 3.63819439307502e-07 1.46888144061281e-05 330 958.727272727273 1055 3.30744999521124e-08 112 1.33724522676656 1.39269362656857 1 24.5321874134177 329 1138 112 1313 1055 1991 1518 369 1019 398 1304 792 M16302 GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 79/167 Gene Ontology BP GO:0071260 0.00473657255067072 0.0242468647770277 380 1031.09090909091 1055 0.00043152737968442 214 1.50062556198191 1.50062556198191 1 9.20120494394208 379 1955 770 1382 1769 1874 1055 214 1442 225 277 793 M12374 GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. 7/37 Gene Ontology BP GO:0033081 0.000800955733896121 0.00697718099902381 320 1414 1056 8.01244568964263e-05 38 1.21455215107271 1.21455215107271 1 9.94114965442157 319 1056 3899 2436 3265 190 38 499 2189 1403 260 794 M15573 GO_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. 24/132 Gene Ontology BP GO:0009620 0.00901689160572025 0.0376543148358367 865 1331.54545454545 1056 0.000823096507188036 361 1.51746024606229 1.51746024606229 1 8.20334614335776 864 879 1056 1326 361 1805 1142 3809 581 2421 403 795 M15914 GO_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. 269/738 Gene Ontology BP GO:0030855 6.94938658605229e-08 3.66659112716373e-06 715 1013.45454545455 1056 6.31762436870034e-09 88 1.38170283690445 1.47797956704533 1 28.5088932327222 713 342 88 990 1259 1783 1427 1714 1056 463 1313 796 M16728 GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. 185/481 Gene Ontology BP GO:0002237 1.13645312606258e-06 3.74223536475783e-05 265 1071.90909090909 1056 1.03313973920013e-07 136 1.37259124584737 1.37259124584737 1 23.0645569509698 261 1077 136 1073 2183 1563 732 650 2254 806 1056 797 M12392 GO_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that modulates the frequency, rate or extent of thymocyte aggregation. 7/37 Gene Ontology BP GO:2000398 0.000800955733896121 0.00697718099902381 320 1415.18181818182 1057 8.01244568964263e-05 39 1.21455215107271 1.21455215107271 1 9.94114965442157 320 1057 3902 2437 3266 191 39 500 2190 1404 261 798 M11941 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. 274/657 Gene Ontology BP GO:1902532 0.00226122394865293 0.0142841670661164 935 1146 1059 0.000205777404566202 151 1.21551477335215 1.28552604580025 1 8.51330106291909 933 2696 1433 1059 393 1870 1587 151 1207 979 298 799 M13421 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. 79/302 Gene Ontology BP GO:0021953 0.00111498826561935 0.00836979157328558 930 1245.27272727273 1060 0.000101413977934205 143 1.3847066914577 1.40154520515463 1 10.9184548275196 927 863 384 1105 2096 2131 1978 956 1060 143 2055 800 M14622 GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of guanylate cyclase activity. 8/14 Gene Ontology BP GO:0031282 0.0220297881196836 0.0703165418311277 3450 1975.09090909091 1060 0.0022251274864768 539 1.29245240179828 -1.29245240179828 -1 5.65626093349804 3446 836 4261 719 650 2347 4483 2761 539 624 1060 801 M12404 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 249/586 Gene Ontology BP GO:0044089 0.0262744710393933 0.0793159598585406 1920 1337.81818181818 1061 0.00241760132267052 630 1.2315336451897 1.3162435405388 1 5.14515631694205 823 1917 699 644 1343 2905 1992 630 1061 783 1919 802 M13572 GO_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION.html A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. 102/242 Gene Ontology BP GO:0007369 0.00019676465841672 0.00242649293029994 320 1267.36363636364 1062 1.78892962684339e-05 282 1.49787761225903 1.50989163618495 1 14.8682117155138 317 2552 282 2200 1435 1274 1062 677 2514 590 1038 803 M15998 GO_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BINDING.html Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 205/486 Gene Ontology BP GO:0051098 0.00108838329699639 0.00830040181453953 1665 1500.54545454545 1064 9.89929195326869e-05 100 1.35406900095601 1.40786124996836 1 10.6954588567799 1662 482 836 513 100 4621 2669 1090 1064 992 2477 804 M10455 GO_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. 152/408 Gene Ontology BP GO:0007517 6.68100343348291e-09 5.08522933469855e-07 435 1004.45454545455 1065 6.07363950342901e-10 61 1.67584818995332 1.60948519593267 1 40.0356806001296 431 1355 61 809 1065 2091 1289 1764 739 121 1324 805 M13908 GO_NEUROGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROGENESIS.html Generation of cells within the nervous system. 683/1999 Gene Ontology BP GO:0022008 2.77667890373668e-06 8.00752804350895e-05 840 1393.72727272727 1065 2.77668237321836e-07 9 1.42166028295617 1.52365493839385 1 22.1063063053929 838 326 4153 308 1171 3716 1579 1065 943 9 1223 806 M14318 GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. 48/121 Gene Ontology BP GO:0032231 0.0517795369477731 0.125870361281943 1140 1101.54545454545 1066 0.00482181462021541 347 1.21197852779296 1.18244690285147 1 4.14077459259125 1140 939 786 356 1719 1961 1034 1633 1136 347 1066 807 M16239 GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. 365/1026 Gene Ontology BP GO:0045596 1.26276059740427e-08 8.49709775905508e-07 1210 1290.18181818182 1066 1.14796418604753e-09 69 1.3513641866935 1.37792168007548 1 31.1401363678241 1208 179 69 348 850 3824 2174 1613 1066 249 2612 808 M16939 GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of cell proliferation. 406/1017 Gene Ontology BP GO:0008285 2.35586046650779e-05 0.000480215452448101 645 1034.81818181818 1067 2.14171426774157e-06 197 1.33690543062975 1.39273701491018 1 16.8406208797656 645 1067 197 778 1274 2202 1083 559 1868 483 1227 809 M10957 GO_SPHINGOMYELIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOMYELIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. 6/14 Gene Ontology BP GO:0006684 0.0169509718087258 0.0590422821514731 710 1538.09090909091 1068 0.00170816781724013 427 0.451260072561143 -0.451260072561143 -1 2.10488499075588 710 1350 3663 2370 1068 483 661 427 2484 3124 579 810 M11988 GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. 47/117 Gene Ontology BP GO:0030004 0.0839184282471183 0.158445571591463 1450 1315.90909090909 1068 0.00793650793650794 303 1.51627028258991 1.80389653778312 1 4.60509849416153 1450 617 1068 482 3968 1373 984 1089 303 904 2237 811 M12425 GO_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMOCYTE_AGGREGATION.html The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. 31/63 Gene Ontology BP GO:0071594 0.0301326990692728 0.0866291775719094 1100 1526.36363636364 1068 0.00277759169851145 606 1.83218663396852 2.05369581223184 1 7.38820202391812 1097 3744 1614 2275 733 1068 821 3129 606 946 757 812 M14256 GO_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_IN_THYMUS.html The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. 31/63 Gene Ontology BP GO:0033077 0.0301326990692728 0.0866291775719094 1100 1536.27272727273 1069 0.00277759169851145 607 1.83218663396852 2.05369581223184 1 7.38820202391812 1098 3745 1615 2276 734 1069 822 3225 607 950 758 813 M14936 GO_POSITIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 231/537 Gene Ontology BP GO:0045862 0.0081388592683121 0.0353165640960496 2090 1363.81818181818 1071 0.000742647791102763 334 1.31321497308093 1.41234286916076 1 7.23795902776514 2087 345 1071 620 334 2281 2741 487 1147 1024 2865 814 M15435 GO_CELLULAR_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. 283/767 Gene Ontology BP GO:0055082 1.04229199527208e-06 3.53794148465773e-05 515 977.636363636364 1071 9.47538626434666e-08 133 1.35488695409269 1.61412104140208 1 22.892446917563 512 1071 133 1119 1298 1411 994 1037 1106 858 1215 815 M15990 GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. 62/167 Gene Ontology BP GO:0072593 0.0237386962371751 0.0740220057953015 2915 1666.72727272727 1073 0.00218170743974911 43 1.39374807866626 1.48451182529234 1 5.98157472521373 2911 43 1073 688 640 4046 2271 1700 701 829 3432 816 M11103 GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 207/577 Gene Ontology BP GO:0019221 0.0397160736212332 0.104476900749794 705 1188.72727272727 1074 0.00367742905316712 690 1.42165094015802 1.48168666544592 1 5.29371110079972 704 1415 920 1597 858 2163 690 747 1178 1730 1074 817 M12572 GO_MUSCLE_STRUCTURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_STRUCTURE_DEVELOPMENT.html The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. 239/653 Gene Ontology BP GO:0061061 4.43860212495057e-11 6.86947655538183e-09 695 1259.63636363636 1074 4.03509284094557e-12 30 1.65496945320734 1.64261434295722 1 51.2803607787373 695 1074 30 766 1510 2927 1639 2082 898 174 2061 818 M13580 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. 79/186 Gene Ontology BP GO:2000379 0.0619683095503802 0.142294194481907 2255 1689.81818181818 1074 0.00579871719935083 220 1.38207193425154 1.4474596895602 1 4.4424781697504 2255 220 954 641 1074 4128 3396 1360 716 800 3044 819 M15455 GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. 27/69 Gene Ontology BP GO:0034637 0.0133624671063272 0.050114648444812 1490 1118.90909090909 1075 0.00122221142145611 190 2.00389745263357 2.25889861850582 1 9.88866975140209 1486 1377 838 190 464 2465 2362 1075 205 471 1375 820 M13991 GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that stops or reduces the activity of an enzyme. 416/1178 Gene Ontology BP GO:0043086 0.0023614716796996 0.0146728659641204 1195 1204.18181818182 1077 0.00021491002638168 178 1.38375001902647 1.45521697907234 1 9.63035383226815 1192 178 435 337 1120 4535 1827 713 1077 426 1406 821 M10067 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. 69/164 Gene Ontology BP GO:0050680 0.0218829925577054 0.0699743350175113 995 1257.27272727273 1078 0.00200943080272909 416 1.54082475524031 1.54082475524031 1 6.75562418042091 991 506 669 474 1579 3127 2115 1078 1432 416 1443 822 M13894 GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. 36/71 Gene Ontology BP GO:0034446 0.0223136226361085 0.0709603766434601 175 1276.45454545455 1079 0.00204938240756027 175 1.25132253277426 1.25132253277426 1 5.45745936094419 175 2559 1113 1761 3165 664 424 475 2221 1079 405 823 M14377 GO_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_FORMATION.html Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. 80/190 Gene Ontology BP GO:0035148 0.0839184282471183 0.158445571591463 1145 961 1079 0.00793650793650794 221 1.47264052941214 1.48655257140718 1 4.47258959190689 507 221 2102 376 1660 1172 1079 1144 357 808 1145 824 M15992 GO_NEUTRAL_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSPORT.html The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/38 Gene Ontology BP GO:0015804 0.0738083183979603 0.158445571591463 1080 1312.90909090909 1079 0.00694613297239732 513 1.32018948758027 1.4836078808557 1 4.00957711236328 1079 1548 1481 1516 2566 2335 1071 801 567 965 513 825 M14252 GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. 115/250 Gene Ontology BP GO:0006575 0.0306890658815372 0.0880107059221601 1910 1406.09090909091 1080 0.00282961064013309 449 1.4003199669781 -0.944544408431016 -1 5.61019738305039 1906 1080 713 845 1063 449 2343 3303 603 1978 1184 826 M15667 GO_MECHANOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of a mechanical stimulus. 8/22 Gene Ontology BP GO:0007638 0.0508735723467792 0.124289071278 1145 1248.45454545455 1080 0.00520771929401462 272 1.51935086267539 -1.51935086267539 -1 5.22258988334028 1142 1453 4437 1075 1148 371 784 1080 272 1523 448 827 M16156 GO_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the cell. 336/901 Gene Ontology BP GO:0019725 2.21111196163121e-06 6.56874663196647e-05 655 1031.81818181818 1080 2.01010380355853e-07 148 1.34398840510099 1.56957490537969 1 21.3373518485719 651 1068 148 1203 1264 1441 884 898 1572 1080 1141 828 M11002 GO_SINGLE_ORGANISM_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELL_ADHESION.html The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. 262/734 Gene Ontology BP GO:0098602 2.25562001704679e-09 2.01400841137466e-07 840 1244.18181818182 1081 2.05056365396313e-10 52 1.47391089521427 1.54640420986038 1 37.4619112528178 839 1758 52 909 2336 2511 1261 845 1081 543 1551 829 M15304 GO_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 96/277 Gene Ontology BP GO:0048863 3.19524490530036e-09 2.74731890653881e-07 1075 1261.54545454545 1081 2.90476809994645e-10 54 1.35921576383129 1.49532758721956 1 33.8510146029484 1075 1081 54 472 2638 2524 1164 1733 964 156 2016 830 M16654 GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 4/15 Gene Ontology BP GO:0060628 0.00174094640388613 0.0117148031206424 670 1579.72727272727 1081 0.000174231181209641 85 0.73426504557095 0.73426504557095 1 5.38272207483261 670 1197 4596 1669 1081 500 167 140 2719 4553 85 831 M13645 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. 18/34 Gene Ontology BP GO:1900078 0.0550799472552043 0.131566902405086 670 1343.27272727273 1082 0.005137209656935 581 0.431085154698986 0.522241177609464 1 1.4413647898258 666 1387 2543 1106 1082 862 581 714 1425 3797 613 832 M13756 GO_VESICLE_COATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COATING.html A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. 56/116 Gene Ontology BP GO:0006901 0.000694377795223353 0.00637153380083405 3940 1607.81818181818 1082 6.31451869081433e-05 45 1.15399425547617 1.24836586100728 1 9.61822556504981 3938 45 2047 282 72 973 3547 1945 440 1082 3315 833 M13810 GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS.html Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. 17/71 Gene Ontology BP GO:0021952 0.0168301231568629 0.0587094378792744 465 1044.45454545455 1082 0.00154184278019023 219 1.31394404283802 1.31394404283802 1 6.14108610204466 461 1171 1686 1457 2016 331 284 631 1082 2151 219 834 M12114 GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of epithelial cell proliferation. 173/422 Gene Ontology BP GO:0050678 0.000171284266436365 0.00217532558900291 820 1045.72727272727 1085 1.55725094073627e-05 194 1.51409445751669 1.52445637923259 1 15.3019175865461 819 194 278 363 1609 2000 1857 1299 1085 387 1612 835 M13972 GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. 10/26 Gene Ontology BP GO:0045073 0.0022765897189987 0.0143616930235203 820 1366.81818181818 1085 0.000207177180314547 152 1.46584243959724 1.46584243959724 1 10.253482557149 817 2220 1085 1589 3511 904 1003 152 1347 1701 706 836 M12767 GO_POSITIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIVISION.html Any process that activates or increases the frequency, rate or extent of cell division. 61/192 Gene Ontology BP GO:0051781 0.00793287771494109 0.0346092586912415 2355 1438.27272727273 1089 0.000723784340978241 324 1.41621276146308 1.54878833605444 1 7.85287681340616 2351 1089 629 490 331 3675 1195 2398 678 324 2661 837 M16709 GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 200/469 Gene Ontology BP GO:0071214 0.0190733662578413 0.0640129004356896 1090 1387.90909090909 1089 0.0017491601992858 315 1.39253512486466 1.44760908580536 1 6.30986990876239 1089 2281 674 1939 811 4234 1796 433 1151 315 544 838 M11800 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 664/1619 Gene Ontology BP GO:0051130 0.00840835669210718 0.0362020544295597 1060 1583.63636363636 1090 0.000844034236506303 186 1.3348222190469 1.46166439969537 1 7.30255834907338 1057 1878 3807 1041 1024 4056 1657 399 1090 186 1225 839 M14284 GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 9/38 Gene Ontology BP GO:0060117 0.0302957665568586 0.0869902561060572 485 1334.27272727273 1091 0.00307168947448595 42 1.9555202969072 1.9555202969072 1 7.87213018688985 482 2576 4217 1325 777 1091 1502 737 42 679 1249 840 M11385 GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 38/160 Gene Ontology BP GO:0001676 0.000140292426473475 0.00185577702597249 1950 1069.54545454545 1092 1.27546703290866e-05 32 1.20631166348961 1.52862599404657 1 12.5073084886375 1949 253 554 180 32 2186 1092 1549 379 1130 2461 841 M12632 GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. 361/914 Gene Ontology BP GO:0007167 0.00043953570628108 0.00440769823814914 605 966 1092 3.99657768392284e-05 134 1.36066023736662 1.39944154758308 1 12.1672703174426 604 1203 328 429 1347 1714 1229 1587 959 134 1092 842 M14623 GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of monocyte differentiation. 5/19 Gene Ontology BP GO:0045655 0.0848858281666945 0.159694043832238 1020 2001.90909090909 1093 0.00883141626596133 566 0.37600835004116 -0.459653004331206 -1 1.13711840089745 1018 751 4262 1667 4613 802 1093 863 2327 4059 566 843 M16598 GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 18/39 Gene Ontology BP GO:0010922 0.0265891336893366 0.0797535465009727 1210 1249 1093 0.00244691218077902 279 2.18771116543902 2.18771116543902 1 9.12007530960028 1210 2816 1093 1371 684 1613 936 1077 279 1074 1586 844 M12226 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 38/71 Gene Ontology BP GO:1902041 0.00356485535652158 0.0197277990707148 1735 1086 1095 0.000324604086037724 150 1.58511170728697 1.80777235942664 1 10.2582069784541 1733 1635 1200 150 201 2675 1519 1095 403 415 920 845 M16285 GO_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. 40/129 Gene Ontology BP GO:0001823 0.0453092381782544 0.114768572210385 3970 2147.63636363636 1096 0.00420638287967497 221 1.6361024677156 1.69783601528402 1 5.83885060230198 3970 1096 942 774 929 3634 2844 4611 221 453 4150 846 M15143 GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 32/102 Gene Ontology BP GO:0060193 0.00137976362953518 0.00976561361574976 1680 1444.36363636364 1100 0.000125511793631412 116 1.55250524272995 1.73198783511034 1 11.8468060694219 1678 1100 863 675 116 2878 1123 3534 250 576 3095 847 M14028 GO_NEURON_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_CELL_CELL_ADHESION.html The attachment of a neuron to another cell via adhesion molecules. 4/22 Gene Ontology BP GO:0007158 0.000999550119979004 0.00804317366908581 3875 1953 1101 1e-04 34 1.51935086267539 -1.51935086267539 -1 12.0798270472807 3875 318 4174 34 3549 3120 4599 343 83 1101 287 848 M10425 GO_B_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 16/28 Gene Ontology BP GO:0001782 0.0121120782568565 0.046361400945247 1165 1061.45454545455 1102 0.00110720724780271 351 1.86246399913557 1.86246399913557 1 9.4297456357673 1162 2387 1343 1102 1739 1212 554 351 366 995 465 849 M12783 GO_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIOGENESIS.html The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. 101/263 Gene Ontology BP GO:0042063 0.0665363661593723 0.149529694132607 1040 1372.90909090909 1104 0.00623983934171904 302 1.45753127027538 1.43543979822941 1 4.5658591990221 1040 359 1055 302 1104 3685 1375 3012 836 1127 1207 850 M15521 GO_REGULATION_OF_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. 17/43 Gene Ontology BP GO:0098801 0.0251748924317274 0.07705143412031 405 1558.27272727273 1104 0.00231524303783016 402 1.45023161899474 1.45023161899474 1 6.12809257740068 402 2302 693 2040 3254 618 1104 1026 2504 2158 1040 851 M12173 GO_EMBRYO_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT.html The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. 469/1244 Gene Ontology BP GO:0009790 9.05497238084628e-09 6.37003587337413e-07 660 1114.45454545455 1105 8.23179310737784e-10 66 1.42744945612549 1.46679406701359 1 33.5713986275868 658 1563 66 1158 1105 2544 1672 882 1048 103 1460 852 M11242 GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html The directed killing of a target cell by a leukocyte. 26/73 Gene Ontology BP GO:0001909 0.0119567450752177 0.0460706783271667 805 1406.63636363636 1106 0.00109292976259408 190 0.955856589839509 0.955856589839509 1 4.84946055363537 801 1106 2555 946 2832 883 407 1880 1411 2462 190 853 M12982 GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. 17/32 Gene Ontology BP GO:0090049 0.0839184282471183 0.158445571591463 1030 1502.72727272727 1106 0.00793650793650794 466 1.19045135446987 1.19045135446987 1 3.6155465174851 1028 552 2513 572 2731 1927 1060 2426 466 2149 1106 854 M15200 GO_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. 50/124 Gene Ontology BP GO:0019218 0.0820067064184065 0.158445571591463 1090 1182.18181818182 1107 0.00774847855001404 53 1.17636211900458 1.08381004908522 1 3.57275578434698 1090 53 986 419 1211 1525 1107 2675 1369 969 1600 855 M15823 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein. 7/25 Gene Ontology BP GO:0042523 0.0237301472723107 0.0740220057953015 790 1450.90909090909 1108 0.00239874264125923 289 1.21455215107271 1.21455215107271 1 5.21251620754228 789 1707 4463 1108 2411 389 514 537 2324 1429 289 856 M11329 GO_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. 516/1254 Gene Ontology BP GO:0051338 0.0534696797948844 0.128631980978056 1110 1387.09090909091 1109 0.0054801563385875 456 1.41460353793689 1.4627389497961 1 4.78244023355447 854 1464 3731 515 1459 2837 989 734 1109 1110 456 857 M13074 GO_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_B_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. 31/57 Gene Ontology BP GO:0043491 0.00240649949461169 0.0148582142998432 895 1161.36363636364 1110 0.000219012355878922 155 1.44611373340757 1.44611373340757 1 10.034455326487 894 1162 1123 1063 155 2674 1208 1110 787 948 1651 858 M10725 GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. 10/44 Gene Ontology BP GO:0007202 0.0046210858922471 0.0238396686641148 1115 1073.09090909091 1112 0.000420983735800583 244 1.36442673446469 1.36442673446469 1 8.40418550554744 1112 1046 917 1692 244 1936 1117 1355 449 719 1217 859 M11395 GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of intracellular signal transduction. 883/2243 Gene Ontology BP GO:1902531 0.0424626855648039 0.109330805980255 525 1244 1113 0.00432965868488202 335 1.33588343057241 1.39091247527109 1 4.87433656365781 523 1351 3736 769 1113 2011 1153 670 1125 335 898 860 M16661 GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS.html Any process that alters the size or shape of an auditory receptor cell. 8/25 Gene Ontology BP GO:0002093 0.0488635497526882 0.120421157909624 570 1476 1115 0.00499724660103124 36 1.9555202969072 1.9555202969072 1 6.82378754639321 570 2542 4598 1079 2369 1115 1394 709 36 626 1198 861 M12562 GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 6/20 Gene Ontology BP GO:0045076 0.0135413778898533 0.0506628666741247 1595 1441.45454545455 1118 0.00136246085977839 308 0.78779702467706 -0.858347262183827 -1 3.87342691644772 1595 308 3932 1118 489 372 542 459 2337 3524 1180 862 M14195 GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT.html The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. 5/12 Gene Ontology BP GO:0043369 0.00118485840346063 0.00877399930983683 965 1315.27272727273 1118 0.000118549062818646 86 2.24458518468169 2.24458518468169 1 17.5241069239165 962 1915 4201 1572 860 1799 1118 104 86 1201 650 863 M10104 GO_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DEVELOPMENT.html The progression of an endothelial cell over time, from its formation to the mature structure. 27/70 Gene Ontology BP GO:0001885 0.0453958285281969 0.114925208209606 1015 1766.63636363636 1119 0.0042145939795214 615 2.76431492756404 2.76431492756404 1 9.85895051157827 1015 3001 1119 2781 4638 1607 615 663 714 2485 795 864 M12766 GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION.html The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 82/271 Gene Ontology BP GO:0009952 0.00958861611038051 0.0392592104060817 545 1036.18181818182 1119 0.000875514956894539 390 1.49156528272144 1.56594425212715 1 7.96072952989635 542 2003 568 1178 1016 1182 1230 1126 1044 390 1119 865 M13378 GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION.html Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 12/24 Gene Ontology BP GO:0010935 0.00987103081295051 0.0401323958533531 385 1094.81818181818 1120 0.000901418244807171 358 1.51351096353794 1.51351096353794 1 8.02297188157872 1431 732 571 358 2246 1956 1120 384 1667 382 1196 866 M14324 GO_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. 212/578 Gene Ontology BP GO:0022407 5.57206481135683e-05 0.000910855220952734 580 1196.09090909091 1120 5.06564176655258e-06 231 1.31300603819607 1.32844968798049 1 15.1539620897597 578 1075 231 786 1854 2301 1392 1364 1120 659 1797 867 M12540 GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. 10/22 Gene Ontology BP GO:0031061 0.0439470305472137 0.112051654492429 435 1195.90909090909 1122 0.00407729789277275 324 1.13115893914357 -1.13115893914357 -1 4.08150492033298 432 1340 2165 1551 911 324 709 1122 2172 1691 738 868 M12619 GO_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYMERIZATION.html The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. 43/96 Gene Ontology BP GO:0051258 0.011412997147148 0.0446545786265953 965 1356.27272727273 1123 0.00104296711486713 98 0.80907696226456 -0.741547221467398 -1 4.14642621691393 965 1776 2284 1000 2520 98 620 1123 1538 2692 303 869 M10744 GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 10/29 Gene Ontology BP GO:0072207 0.0459597824328467 0.115860574033061 3565 1928.63636363636 1124 0.00426808858667957 96 1.4981706652067 1.55267185908911 1 5.32321752942641 3561 898 1124 347 1017 3893 2856 3748 96 312 3363 870 M13315 GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. 9/20 Gene Ontology BP GO:0035358 1.65363254923725e-05 0.000363877532043059 440 1450.54545454545 1124 1.65364485461886e-06 3 0.58705296295576 0.740146003128947 1 7.66341498137962 437 2400 4050 2271 1124 75 230 52 1609 3705 3 871 M11149 GO_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that modulates the frequency or rate of macrophage activation. 11/34 Gene Ontology BP GO:0043030 0.00686668959895982 0.0311348044999711 1435 1426.27272727273 1126 0.000626201471751743 130 1.37894428091892 1.37894428091892 1 7.88671706542761 1432 1979 1126 2052 3989 1106 130 1025 1930 331 589 872 M11927 GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY.html Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 120/367 Gene Ontology BP GO:0050803 0.0614931813572655 0.141709283336511 1130 1549.90909090909 1126 0.00575294782713403 579 1.43333866291971 1.51721991470885 1 4.61700073137354 1126 2372 1065 929 1072 2019 1743 3078 935 579 2131 873 M13553 GO_POSITIVE_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINESIS.html Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. 17/66 Gene Ontology BP GO:0032467 0.0151010030746884 0.0544610285315552 2260 1342.90909090909 1126 0.00138233317432099 494 0.967843427962502 -0.862559895960135 -1 4.64333391573533 2259 548 1984 944 494 781 1969 1571 946 2150 1126 874 M11263 GO_IMMUNE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. 383/940 Gene Ontology BP GO:0002520 0.0192816246770972 0.0644989793773503 1030 1258.90909090909 1127 0.00176842901196694 304 1.38753434334559 1.44959870051851 1 6.26990693714903 1030 2042 652 1191 971 2764 1561 967 1127 304 1239 875 M12438 GO_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 86/203 Gene Ontology BP GO:0043279 0.0011028967888894 0.00831290550456738 475 1177.45454545455 1127 0.000100313643441248 96 1.31938464012559 1.42926438603427 1 10.4182216260045 473 699 1127 1582 2103 1244 596 96 1873 2722 437 876 M12246 GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an external stimulus. 522/1381 Gene Ontology BP GO:0032101 0.0674886946424906 0.151376816050765 1035 1509.18181818182 1128 0.00696304526027788 319 1.30150764532087 1.36594931759843 1 4.05075861053591 1032 331 3875 319 1157 3324 1720 987 1128 589 2139 877 M14159 GO_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 625/1567 Gene Ontology BP GO:0009628 0.0189982884856248 0.0638733189274119 1035 1630.09090909091 1128 0.00191626908298792 239 1.43532899056665 1.49719815309255 1 6.50894300935493 1002 1202 4193 1071 1128 3954 1550 1035 1032 239 1525 878 M12045 GO_LIPID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. 58/179 Gene Ontology BP GO:0055088 0.00851252281482936 0.0363937784799749 750 1298 1129 0.000776876372744152 345 1.54015782325442 1.64057911266696 1 8.41249962720483 746 2050 922 2136 345 1384 482 934 2557 1129 1593 879 M12814 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. 14/35 Gene Ontology BP GO:0045987 0.000198770404677202 0.00242866049714802 330 1073.18181818182 1129 1.8071669626526e-05 37 1.9083122944764 1.9083122944764 1 18.9394537655219 330 2174 1129 2038 2244 118 77 37 1370 2020 268 880 M13171 GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS.html The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. 20/73 Gene Ontology BP GO:0001658 0.0385396510160018 0.102076212017853 2495 1697 1129 0.00356652963490109 190 1.59377735983069 1.66198038729363 1 5.99572361129013 2493 2021 805 1120 837 4179 1979 3596 190 318 1129 881 M14753 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 457/1268 Gene Ontology BP GO:0051093 4.3639494786626e-09 3.49341679817767e-07 340 1433.54545454545 1131 3.96722680665363e-10 58 1.35115811089399 1.37353379659136 1 33.1151973606288 1277 336 58 338 948 4327 2393 2002 1131 268 2691 882 M15939 GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS.html The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. 8/15 Gene Ontology BP GO:0003222 0.0703843581635774 0.156286262531559 1045 1539.09090909091 1131 0.00727183796676998 233 1.70820157422404 1.70820157422404 1 5.22665772534787 1045 743 4482 1131 4254 1279 457 1260 233 1527 519 883 M14526 GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 71/175 Gene Ontology BP GO:0090263 0.0195953637079594 0.0651261801689732 2335 1414.36363636364 1132 0.00179746429167912 290 1.55712330472985 1.71108396913728 1 7.01139458051078 2332 772 1279 561 580 2976 2695 1132 348 290 2593 884 M16537 GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. 102/257 Gene Ontology BP GO:0014074 0.00116485077627902 0.00865344344682161 725 1033.27272727273 1133 0.00010595163602514 384 1.10941052653714 1.2158152505481 1 8.68678275455779 725 1420 386 961 384 1476 841 1220 1556 1133 1264 885 M11737 GO_SINGLE_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves only one organism. 56/124 Gene Ontology BP GO:1902591 0.00168554511084841 0.0113775482870691 4440 1756.72727272727 1134 0.000153348899062271 47 1.15399425547617 1.24836586100728 1 8.51522762044198 4439 47 1947 364 124 1134 3996 1622 521 1081 4049 886 M15082 GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. 261/608 Gene Ontology BP GO:0042326 0.0548948408680741 0.131379766056942 995 1339.63636363636 1135 0.00511949396280453 860 1.24453591246002 1.33534909953462 1 4.16411722698777 994 1879 1135 976 1004 2750 1313 938 1146 1741 860 887 M14442 GO_MITOCHONDRIAL_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FUSION.html Merging of two or more mitochondria within a cell to form a single compartment. 11/23 Gene Ontology BP GO:0008053 0.0710588166862918 0.157407483718728 895 1890.36363636364 1136 0.00667849487904473 304 0.282915576095587 -0.313990261582632 -1 0.86231493883762 891 2431 3163 3264 1136 304 1047 939 3043 4019 557 888 M13245 GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. 10/23 Gene Ontology BP GO:2000310 0.0459597824328467 0.115860574033061 2485 1486.36363636364 1137 0.00426808858667957 201 1.43185585027567 -1.3811115522525 -1 5.08759137980844 2484 739 832 201 1137 2324 2561 3896 1266 313 597 889 M12683 GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin receptor signaling. 10/20 Gene Ontology BP GO:0046628 0.0476303207581662 0.118514243987227 585 1541.45454545455 1138 0.00442671861839721 487 0.396544194100175 0.51659294624723 1 1.39417538897508 584 2179 2424 1725 944 544 613 1138 2765 3553 487 890 M13878 GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 269/752 Gene Ontology BP GO:1901699 0.000108348205628778 0.0015384119838973 850 1255.54545454545 1138 9.85032200522532e-06 258 1.2469314707253 1.35096714480905 1 13.3139932411517 850 476 258 1049 1123 2680 1496 1180 1862 1138 1699 891 M14016 GO_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MATURATION.html Any process that modulates the frequency, rate or extent of protein maturation. 42/138 Gene Ontology BP GO:1903317 0.0244374802210899 0.075290790090591 555 1271.45454545455 1139 0.00224665711492291 489 1.1099059725563 1.1099059725563 1 4.73230792743312 551 2010 1139 1852 2190 535 823 489 1612 2127 658 892 M14710 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 614/1522 Gene Ontology BP GO:0031401 0.0765897756730953 0.158445571591463 965 1526.90909090909 1139 0.00793650793650794 395 1.39837797105727 1.46590561917344 1 4.24704510977037 963 1299 4277 565 1370 3518 1225 1073 1139 395 972 893 M11126 GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. 3/20 Gene Ontology BP GO:2000311 0.000999550119979004 0.00804317366908581 1485 1313.90909090909 1140 1e-04 76 1.51935086267539 -1.51935086267539 -1 12.0798270472807 1481 1561 3696 76 2141 1140 263 2163 364 982 586 894 M11141 GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. 20/52 Gene Ontology BP GO:0050869 1.36171648960298e-06 4.42129346938926e-05 1145 1210.63636363636 1144 1.23792484768594e-07 2 1.39746807479799 1.39746807479799 1 23.0984320236199 1571 1782 1423 995 2 2332 1310 1068 547 1144 1143 895 M14935 GO_GLIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. 5/16 Gene Ontology BP GO:0021781 0.0368382589852902 0.0987220318212275 835 1623.45454545455 1146 0.00374635741907742 462 1.65735694990685 1.65735694990685 1 6.32619342539153 832 1877 4320 1146 865 1132 876 3226 1919 1203 462 896 M15805 GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-6 production. 76/195 Gene Ontology BP GO:0032675 0.0356525342226845 0.0966309254951343 1085 1357.09090909091 1148 0.00329488787103499 223 1.32310365655501 1.40975850604812 1 5.09703301876049 1081 223 1148 793 2024 2326 1542 587 1995 1059 2150 897 M16551 GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 26/71 Gene Ontology BP GO:0006636 0.0288136544805233 0.0836659147924138 790 1279.27272727273 1150 0.00265437255827884 269 1.14894413261494 1.28609126820956 1 4.69898271003243 787 2455 1150 1556 2694 868 269 843 1435 1456 559 898 M14110 GO_BLOOD_VESSEL_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_REMODELING.html The reorganization or renovation of existing blood vessels. 20/45 Gene Ontology BP GO:0001974 0.00696245166405071 0.0313486294765926 450 1233.36363636364 1151 0.000634962201101393 267 1.30242931527595 -1.03069309216194 -1 7.43440326050308 448 1898 768 1645 2087 944 700 267 2373 1151 1286 899 M14669 GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. 170/456 Gene Ontology BP GO:0048871 3.38557017636271e-07 1.3910798521108e-05 450 1417.18181818182 1153 3.07779154306064e-08 110 1.38642669897569 1.49862685685148 1 25.5588180713982 446 4244 110 2046 3050 1253 1158 855 1153 263 1011 900 M12663 GO_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a lymphocyte. 63/369 Gene Ontology BP GO:0002449 0.0097990920078819 0.0398843162410805 460 1067.63636363636 1156 0.000894819326264633 167 1.11747994513129 1.14812710889005 1 5.93507344576171 456 1956 1528 1209 474 301 282 1156 2233 1982 167 901 M12714 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. 81/177 Gene Ontology BP GO:0017015 0.0351048145726256 0.0958210782249856 2105 1593.72727272727 1156 0.00324343771641197 499 1.03442681662582 1.1083311866687 1 3.9993060658755 2104 499 760 554 796 3855 2204 824 1977 1156 2802 902 M13980 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 81/177 Gene Ontology BP GO:1903844 0.0351048145726256 0.0958210782249856 2105 1582.90909090909 1157 0.00324343771641197 500 1.03442681662582 1.1083311866687 1 3.9993060658755 2105 500 761 555 797 3856 2205 695 1978 1157 2803 903 M14049 GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. 835/2035 Gene Ontology BP GO:0051247 0.0439002806146558 0.112051654492429 1260 1547.72727272727 1157 0.00447924436632542 281 1.36594735751474 1.42357698292361 1 4.92868037172114 1260 752 4176 281 953 4170 1553 918 1157 337 1468 904 M16736 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS.html Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. 19/76 Gene Ontology BP GO:0021955 0.0738610036897212 0.158445571591463 800 1352.90909090909 1157 0.00695126843847157 509 1.31394404283802 1.31394404283802 1 3.99060893201362 798 1440 1875 1619 2223 972 920 1157 1112 2257 509 905 M15600 GO_LOCALIZATION_WITHIN_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_WITHIN_MEMBRANE.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. 83/194 Gene Ontology BP GO:0051668 0.0540111076346338 0.129732455206741 2605 1732.09090909091 1159 0.00503495931017782 32 1.15022100954121 1.23386732575177 1 3.87247241123969 2601 32 1142 491 1001 2870 3953 1159 1407 587 3810 906 M15408 GO_OUTFLOW_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. 36/92 Gene Ontology BP GO:0003151 0.00109708581778211 0.00830040181453953 1075 1180.54545454545 1160 9.97848445193923e-05 383 1.65034153362789 1.84287991727813 1 13.0356429104738 1074 1160 383 925 1933 1791 1347 1625 725 671 1352 907 M16028 GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of embryonic development. 18/48 Gene Ontology BP GO:0040019 0.0382063881310708 0.101367005767178 2120 1406.45454545455 1160 0.00353513591512749 332 1.68564186465497 1.83387865826151 1 6.36068796692377 2116 2967 1160 560 833 1388 619 2862 332 570 2064 908 M16724 GO_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_SELECTION.html The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. 21/47 Gene Ontology BP GO:0045058 0.00898929589013765 0.0376350773831462 595 1194.63636363636 1160 0.000820567094966522 298 2.05369581223184 2.05369581223184 1 11.1039501852505 594 2529 1490 1973 1270 1160 1005 298 488 1237 1097 909 M11294 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 5/18 Gene Ontology BP GO:0033145 0.01485241833051 0.0538327699520358 1165 1780 1161 0.00149526297141927 216 0.262508020474019 -0.262508020474019 -1 1.26443188355402 1161 2517 3726 2495 1117 242 868 1009 3014 3215 216 910 M13093 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. 14/45 Gene Ontology BP GO:1904037 0.0406286956825015 0.105917481220581 745 1347.45454545455 1161 0.003763545533013 560 1.700555425947 1.700555425947 1 6.29385959104774 744 1174 1161 782 869 2151 1089 1667 560 2021 2604 911 M15313 GO_SCHWANN_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 20/42 Gene Ontology BP GO:0014037 0.0193788239634673 0.0645914426865605 655 1817.81818181818 1163 0.00177742351029931 577 1.21455215107271 1.21455215107271 1 5.48537716096974 655 3054 2625 3709 577 951 1028 974 2957 2303 1163 912 M10933 GO_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. 65/161 Gene Ontology BP GO:0010469 0.0173398523194236 0.0600971175320337 2755 1732.36363636364 1164 0.00158891345990267 544 1.24453483382939 -1.04256424933416 -1 5.76875382458848 2751 1887 1769 887 544 703 3521 4115 1164 894 821 913 M15245 GO_LINOLEIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LINOLEIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 10/30 Gene Ontology BP GO:0043651 0.0118657402729582 0.045872299822935 1380 1148.18181818182 1164 0.00108456598312917 346 1.2815413473491 1.2815413473491 1 6.51091220133706 1378 1290 1665 1164 516 1040 779 346 1801 1708 943 914 M15016 GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 20/45 Gene Ontology BP GO:0002753 0.00186641481566135 0.0122918638143484 1245 1486.81818181818 1166 0.00016981819180851 60 1.06710845596515 1.06710845596515 1 7.73813084527552 1242 956 2834 1166 4495 526 60 1592 633 2301 550 915 M10640 GO_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 225/596 Gene Ontology BP GO:1901652 2.65040651529077e-06 7.6911484065594e-05 645 1106.09090909091 1167 2.40946337120093e-07 151 1.35906813112767 1.42653730661056 1 21.2233373382374 644 186 151 271 1167 2614 1599 1619 1528 458 1930 916 M12105 GO_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_OLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 258/614 Gene Ontology BP GO:0051259 0.0839184282471183 0.158445571591463 1110 1458.90909090909 1169 0.00793650793650794 182 1.37021252480006 1.446995274667 1 4.16150320102183 1106 182 965 1596 1467 3177 958 1072 1169 2380 1976 917 M14680 GO_RESPONSE_TO_YEAST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_YEAST.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. 8/22 Gene Ontology BP GO:0001878 0.0234427353658774 0.0732467162205711 945 1712.27272727273 1170 0.00236937734837636 513 0.947868038846911 0.730185467833597 1 4.08443531870589 942 571 4272 1319 674 513 1170 2762 1933 4072 607 918 M15161 GO_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORT.html The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 24/72 Gene Ontology BP GO:0015918 0.00272980515829623 0.0163330996777956 385 1181 1170 0.000248472568394899 73 1.90919498657043 1.90919498657043 1 12.9498695512579 382 1533 1170 1501 1715 1080 73 378 2347 2419 393 919 M11019 GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein oligomerization. 17/43 Gene Ontology BP GO:0032459 0.00835377496927761 0.0360470048163159 1340 1362.09090909091 1171 0.000762333212399879 285 1.86280643978199 1.86280643978199 1 10.2042399425113 1340 1112 1171 875 3212 2278 1248 285 580 2142 740 920 M15399 GO_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MIGRATION.html The movement of a lymphocyte within or between different tissues and organs of the body. 18/74 Gene Ontology BP GO:0072676 0.00143119736762923 0.00999255545549251 880 1204.36363636364 1172 0.000130193570337632 55 1.45023161899474 1.45023161899474 1 11.0114579154589 877 2671 1172 2273 379 669 55 1206 1429 2209 308 921 M13213 GO_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE.html Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. 298/1073 Gene Ontology BP GO:0045087 8.14023680881613e-06 0.000198840112790348 1105 1911.27272727273 1174 7.40024266247688e-07 175 1.21483998384944 1.35609221558173 1 17.0688237015287 2256 470 175 895 1101 4446 2307 3368 1102 1174 3730 922 M14567 GO_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 46/134 Gene Ontology BP GO:0072091 0.00109945016496701 0.00830040181453953 3640 1672.18181818182 1174 1e-04 57 1.33485368671715 1.40393021799426 1 10.5436818035278 3640 57 1174 82 932 1247 4193 3231 790 893 2155 923 M11312 GO_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 22/50 Gene Ontology BP GO:0010762 0.00109945016496701 0.00830040181453953 1820 1699.63636363636 1175 1e-04 47 1.41882749615543 1.41882749615543 1 11.2069703237398 1818 880 1175 47 4398 3996 2912 682 115 353 2320 924 M16177 GO_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 13/24 Gene Ontology BP GO:0070227 0.000720877819822532 0.00655142673033326 85 1064.18181818182 1180 6.55558308659919e-05 81 1.86280643978199 1.86280643978199 1 15.4404800390544 1413 1444 2665 1101 96 1434 1180 82 246 1964 81 925 M16143 GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. 138/339 Gene Ontology BP GO:0034612 0.00473252308111498 0.0242468647770277 1120 1444.90909090909 1181 0.000431157654398069 213 1.51679737613741 1.58646048358718 1 9.30036370821529 1117 2153 820 1994 670 4364 1201 213 815 1366 1181 926 M16109 GO_FEMALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. 11/23 Gene Ontology BP GO:0030540 0.0425064140325883 0.109339213492137 4190 2381.36363636364 1182 0.00394096454322144 334 1.37091145355478 1.5200039889936 1 5.00197211510959 4188 1182 814 1180 892 4278 4491 3717 505 334 4614 927 M16849 GO_RESPONSE_TO_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. 50/150 Gene Ontology BP GO:0014823 0.0388179947100511 0.102579367921894 940 1264.36363636364 1182 0.00359275749064743 534 1.86441820147633 1.86441820147633 1 6.99875031856838 936 2058 743 1451 1903 1099 534 995 1182 1542 1465 928 M11192 GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 36/108 Gene Ontology BP GO:0051055 0.0484219447774811 0.1197141052193 1405 1396.81818181818 1183 0.00450197755777307 520 1.10233815472542 1.00672811381994 1 3.85730991669192 1403 520 1468 1183 955 1107 903 2803 2239 1911 873 929 M11061 GO_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease. 5/54 Gene Ontology BP GO:0042737 0.142846466345362 0.244195929028541 585 1830.45454545455 1184 0.0152956374434611 581 2.01369544572059 2.01369544572059 1 4.67991566728904 581 1713 3680 1069 4424 1023 614 2049 2726 1184 1072 930 M12283 GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that activates or increases the activity of an enzyme. 766/1913 Gene Ontology BP GO:0043085 0.0604383428372193 0.140307612896605 1185 1557.72727272727 1184 0.00621479126210755 331 1.39756337543996 1.49770251413798 1 4.52466480038515 1184 458 3882 331 1207 4127 1583 871 1079 343 2070 931 M10685 GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. 50/156 Gene Ontology BP GO:0045833 0.0279200755159182 0.0819424213782607 680 1184.90909090909 1186 0.00257098489420108 296 1.10233815472542 1.00672811381994 1 4.54619737264928 678 705 1210 1186 2144 584 478 1391 2021 2341 296 932 M13282 GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition. 95/212 Gene Ontology BP GO:1902806 0.0758730969115222 0.158445571591463 1025 1651.81818181818 1187 0.0071475950008242 703 1.2799617459684 1.31481901864389 1 3.88740053576307 1023 4057 2061 2642 1172 2261 719 1310 1187 1035 703 933 M13347 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. 19/78 Gene Ontology BP GO:0032732 0.0118808147603518 0.0458923651683138 2400 1517.18181818182 1190 0.00108595135270439 437 1.49867453025741 1.49867453025741 1 7.61298391079633 2397 1110 826 1190 437 2174 2040 2934 1371 1122 1088 934 M11671 GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. 5/28 Gene Ontology BP GO:0044788 5.26519894283716e-05 0.000873082810414034 305 1629.36363636364 1192 5.26532369743688e-06 13 1.35593454827845 1.35593454827845 1 15.7440900010473 305 2365 3787 2909 2725 1127 290 13 3006 1192 204 935 M10358 GO_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. 20/56 Gene Ontology BP GO:0097028 0.00885267265707904 0.0371972480966678 2470 1743.09090909091 1193 0.00080804520739222 296 1.22609041857518 1.22609041857518 1 6.65289401280583 2466 538 1193 740 1162 4460 3536 296 1695 1141 1947 936 M15342 GO_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_GROWTH.html Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 28/75 Gene Ontology BP GO:0060420 0.0118932933050276 0.045902378067534 1495 1465.18181818182 1193 0.00108709816551462 379 1.31638599576927 1.3773008990423 1 6.68651912138036 1493 793 590 379 1540 2706 1193 3642 1129 486 2166 937 M10315 GO_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACTIVATION_CASCADE.html A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. 25/269 Gene Ontology BP GO:0072376 0.00205117205810025 0.0132404920242788 700 1212.90909090909 1194 0.000186644270024754 425 1.2029038843803 1.262568823891 1 8.57543022119302 697 637 425 1194 1339 2240 1479 1143 1596 788 1804 938 M13468 GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION.html The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). 7/22 Gene Ontology BP GO:0042074 0.0321281952096276 0.0904616193804129 585 1578.45454545455 1194 0.00326023720153558 433 1.46584243959724 1.46584243959724 1 5.80633126170135 1086 1194 4082 2236 1919 1000 433 583 2839 1410 581 939 M15426 GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 914/2257 Gene Ontology BP GO:0031399 0.0547473617314429 0.131162022971666 1195 1756.90909090909 1195 0.00561448405428191 795 1.34985551655877 1.40932355826441 1 4.52019925703882 1088 1996 4403 1567 1057 3896 1318 816 1195 795 1195 940 M11423 GO_REGULATION_OF_DOPAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of dopamine. 5/27 Gene Ontology BP GO:0014059 0.00244147831745524 0.015034196058282 1200 1427.63636363636 1196 0.00024441648398426 161 1.9366898762468 1.9366898762468 1 13.4009279832877 1196 580 3743 195 1321 2333 3019 161 170 1190 1796 941 M10670 GO_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_PRIMARY_GERM_LAYER.html The formation of the ectoderm, mesoderm and endoderm during gastrulation. 77/178 Gene Ontology BP GO:0001704 0.00114409179651855 0.00851284969749297 460 1130.27272727273 1199 0.000104062473229856 385 1.42728502313088 1.43197672640651 1 11.2143099888928 457 1571 385 1150 1759 1515 1199 917 1506 515 1459 942 M10955 GO_GLUTAMATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. 14/33 Gene Ontology BP GO:0006536 0.00624434697951053 0.0292503558017523 1615 1241.54545454545 1199 0.000569285573233322 284 0.907956294871668 -1.23889395501682 -1 5.28640463311549 1612 891 1616 1199 284 665 2396 458 2020 2008 508 943 M15065 GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 12/32 Gene Ontology BP GO:0050995 0.00523934662894069 0.0258034793819947 625 1888.36363636364 1199 0.00047744236410415 229 0.527507711462031 0.543717979250754 1 3.18034710117101 622 3019 1199 3095 4534 468 453 229 2747 4170 236 944 M15685 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 39/149 Gene Ontology BP GO:0021954 0.146593153524992 0.249133240049978 880 1438 1199 0.014307469091596 737 1.23930131021189 1.30883738289521 1 2.83929540215893 880 1157 1131 1804 2823 1475 1286 1051 2275 737 1199 945 M12937 GO_ENSHEATHMENT_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENSHEATHMENT_OF_NEURONS.html The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. 40/139 Gene Ontology BP GO:0007272 0.00854902557521671 0.0364826523398265 1205 1214.36363636364 1201 0.000780220752090984 346 1.43100846855025 1.59736094186968 1 7.81056093419403 1201 619 1493 484 346 2626 1940 2240 696 1214 499 946 M13182 GO_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT.html Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. 40/139 Gene Ontology BP GO:0008366 0.00854902557521671 0.0364826523398265 1205 1224.63636363636 1202 0.000780220752090984 347 1.43100846855025 1.59736094186968 1 7.81056093419403 1202 620 1494 485 347 2627 1941 2343 697 1215 500 947 M11177 GO_REGULATION_OF_BODY_FLUID_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BODY_FLUID_LEVELS.html Any process that modulates the levels of body fluids. 309/777 Gene Ontology BP GO:0050878 6.81542253293355e-12 1.44383287287589e-09 315 944.727272727273 1204 6.19583866632244e-13 21 1.39864808481645 1.49212323446777 1 46.934444608098 311 1204 21 1269 1451 1336 1417 661 1134 206 1382 948 M14725 GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to another cell. 128/357 Gene Ontology BP GO:0022409 0.00533371846554232 0.0262207873196285 1385 1493.27272727273 1210 0.000486063062505323 506 1.3732659889292 1.41587938743249 1 8.24310954718906 1381 694 506 741 1871 3381 1891 1210 925 1172 2654 949 M11342 GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. 63/351 Gene Ontology BP GO:0002460 0.0456977744797942 0.11562657597258 715 1177.72727272727 1211 0.00424323189506175 715 1.13341573189607 1.16161099948917 1 4.03096780989256 715 1516 764 1660 1546 1211 775 753 1866 1254 895 950 M13215 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). 248/1835 Gene Ontology BP GO:0007186 1.36603194093545e-10 1.58562157544083e-08 435 1054.36363636364 1211 1.24184721910934e-11 40 1.3335614452997 1.48378944597907 1 39.482419102037 435 1263 40 1384 1547 1499 906 1211 1185 765 1363 951 M10829 GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an alpha-amino acid. 114/255 Gene Ontology BP GO:1901605 0.0556623866600576 0.132397777286192 2235 1410.18181818182 1212 0.00519297288372794 442 1.27108272210452 -1.16763306978385 -1 4.23676691326028 2234 1143 903 1512 1012 442 2767 1842 1212 1367 1078 952 M16676 GO_STABILIZATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_STABILIZATION_OF_MEMBRANE_POTENTIAL.html The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 5/16 Gene Ontology BP GO:0030322 0.021097591498986 0.0681645940254237 810 1591.18181818182 1212 0.00213006082401202 239 1.53960170275972 1.53960170275972 1 6.81676692769021 810 1950 4603 1239 2185 1056 239 1013 2143 1212 1053 953 M10513 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 67/192 Gene Ontology BP GO:1903555 0.00763823868034935 0.0336473834846888 630 1310.54545454545 1215 0.000696807973465978 547 1.34115750635379 1.43142312580666 1 7.49901325925678 627 935 547 1288 2161 1774 1215 678 2516 928 1747 954 M11979 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. 27/79 Gene Ontology BP GO:2000107 0.108239018630023 0.194486750580184 520 1652.72727272727 1215 0.0103602445829392 516 1.51219857869234 1.51219857869234 1 4.08181042117777 837 2885 978 2636 4519 517 516 1215 2008 1471 598 955 M11220 GO_THYMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMUS_DEVELOPMENT.html The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. 29/80 Gene Ontology BP GO:0048538 0.0128703939356065 0.0488518843315876 1220 1336.63636363636 1216 0.00117693732303023 437 1.77926461375986 1.77926461375986 1 8.85502471245926 1216 1847 1945 1193 456 1333 667 3269 437 1562 778 956 M14093 GO_VENTRICULAR_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_DEVELOPMENT.html The progression of the ventricular septum over time from its formation to the mature structure. 40/78 Gene Ontology BP GO:0003281 0.0232555000219604 0.0729326124758788 1535 1351.18181818182 1216 0.0021368206507583 618 1.27400634188024 1.34109966161461 1 5.49881572020565 1535 618 955 1171 632 2441 716 1611 1773 1216 2195 957 M15094 GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. 8/26 Gene Ontology BP GO:0043567 0.0400691138153288 0.105167267068723 690 2099 1218 0.00408104886091007 688 0.900416075626817 0.900416075626817 1 3.34304597426932 688 3367 4351 2150 912 1024 898 1218 3145 4183 1153 958 M15924 GO_MODULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 138/448 Gene Ontology BP GO:0050804 0.0199560667929317 0.0658893793060532 1270 1414.72727272727 1219 0.0018308563448486 563 1.44653392746976 1.64246598050232 1 6.48565174994985 1266 762 655 632 1222 3432 2378 1219 859 563 2574 959 M10163 GO_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 56/235 Gene Ontology BP GO:0007586 0.00491514818220567 0.0247950740359018 750 1343.18181818182 1220 0.000447833079244155 497 1.45324419107198 1.45324419107198 1 8.85712027960052 750 1770 497 987 1220 1461 895 1243 2257 2776 919 960 M11435 GO_OXALOACETATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALOACETATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. 7/12 Gene Ontology BP GO:0006107 0.011578683819126 0.04506272336312 1220 1256.54545454545 1220 0.0011639459637802 241 1.23889395501682 -1.23889395501682 -1 6.33060660512486 1220 1665 3745 1897 453 675 1560 549 418 1399 241 961 M11397 GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 24/67 Gene Ontology BP GO:0009187 0.0390316600538785 0.103026718379851 710 1982.63636363636 1222 0.00361289549967588 314 1.31505585488108 1.31505585488108 1 4.92709166029949 709 2844 850 3871 4102 717 314 990 3776 2414 1222 962 M12119 GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 83/217 Gene Ontology BP GO:0046890 0.0335915097220133 0.0932003951166524 960 1309.54545454545 1223 0.0031014230177395 501 1.17761801623693 1.20964027383029 1 4.60674665380751 958 501 730 1402 1686 1561 1203 1559 2670 1223 912 963 M14226 GO_MONOSACCHARIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSPORT.html The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 26/83 Gene Ontology BP GO:0015749 0.263972553234506 0.380038624703197 650 1711.27272727273 1226 0.0274779532425355 650 0.997293395573521 0.997293395573521 1 1.59058745551419 650 795 1462 1170 3044 1226 1141 1330 3076 3951 979 964 M15668 GO_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_RESORPTION.html The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. 16/39 Gene Ontology BP GO:0045453 0.010090111318573 0.0408600221908083 880 1464.27272727273 1226 0.000921517099372579 304 1.20041951654789 1.20041951654789 1 6.32774767006236 879 3846 1853 1226 2041 2050 1459 315 304 1009 1125 965 M14191 GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 103/238 Gene Ontology BP GO:0031345 0.00490859714486617 0.0247950740359018 610 1372.90909090909 1227 0.000447234858539521 208 1.39452874812426 1.37892598380537 1 8.49926593986654 1227 208 496 656 610 3589 1780 1918 1756 607 2255 966 M12913 GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 24/48 Gene Ontology BP GO:0070169 0.0202083959616024 0.066358534091079 3635 1520.45454545455 1228 0.00185422233550022 403 1.29014949777142 1.22394260482981 1 5.76939947143978 3631 1228 1052 955 589 2409 1772 1555 513 403 2618 967 M16425 GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. 59/153 Gene Ontology BP GO:0001936 0.0160482732267731 0.0568362688050061 690 1339.45454545455 1228 0.00146968634174862 630 1.66409842843252 1.66409842843252 1 7.86658409521043 690 1217 630 1228 1892 914 1185 1334 1869 2483 1292 968 M10497 GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH.html The activation of endogenous cellular processes that result in the death of a cell as part of its development. 20/41 Gene Ontology BP GO:0010623 0.00334591453847819 0.0189452209782369 365 1270.27272727273 1232 0.000304637645612135 86 1.53150662091758 1.53150662091758 1 10.0134889333316 362 1232 1677 1762 2809 350 86 280 2724 2279 412 969 M13401 GO_EXOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCRINE_SYSTEM_DEVELOPMENT.html Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. 26/75 Gene Ontology BP GO:0035272 0.0194695283346748 0.0648273501378186 1510 1176.54545454545 1232 0.00178581772189802 271 1.1109975320629 1.1109975320629 1 5.01100834127112 1507 271 1232 1225 1182 1493 1400 437 976 1449 1770 970 M15307 GO_DOPAMINERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. 18/46 Gene Ontology BP GO:0071542 0.0839184282471183 0.158445571591463 1235 1460.81818181818 1233 0.00793650793650794 236 1.24207888496845 1.49164084103847 1 3.77234564867915 1353 1233 1168 236 3498 2397 1232 2051 483 568 1850 971 M13511 GO_NEURONAL_ION_CHANNEL_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ION_CHANNEL_CLUSTERING.html The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. 4/29 Gene Ontology BP GO:0045161 0.0765897756730953 0.158445571591463 1840 1541.09090909091 1236 0.00793650793650794 317 0.758877049341482 0.730066911246257 1 2.30480251256588 1839 317 4090 1310 1851 512 754 1236 321 3761 961 972 M16230 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. 93/197 Gene Ontology BP GO:2001242 0.00455426663131772 0.0235472828164902 1250 1249.09090909091 1237 0.000414883811785036 106 1.53028176583154 1.62177495965184 1 9.45690066600882 1246 1359 2243 749 260 3181 1131 1237 785 1443 106 973 M10711 GO_NITROGEN_CYCLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_CYCLE_METABOLIC_PROCESS.html A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. 7/30 Gene Ontology BP GO:0071941 0.0173334973219717 0.0600971175320337 1240 1590.72727272727 1240 0.00174702030257861 209 0.938178160433969 -0.938178160433969 -1 4.34870821127741 1240 1058 3623 856 572 1766 2150 1762 209 3079 1183 974 M14158 GO_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. 71/157 Gene Ontology BP GO:0045444 0.000344112774218944 0.00367290944988174 650 1254.81818181818 1241 3.12878736702422e-05 54 0.983529954055768 -0.804647687222348 -1 9.0905877788786 648 504 1426 1241 54 1281 959 1748 2024 2831 1087 975 M15086 GO_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 7/21 Gene Ontology BP GO:0010463 0.00920343340823452 0.0381531618878865 1465 1378.63636363636 1241 0.000924177350997889 318 1.6234090287657 1.6234090287657 1 8.74088042788253 1462 981 4346 594 903 1627 1723 318 1241 558 1412 976 M16762 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of macrophage differentiation. 10/17 Gene Ontology BP GO:0045651 0.0461450025782042 0.115860574033061 1245 1536 1241 0.00428566416428412 374 1.28983715113895 1.28983715113895 1 4.58297835651727 1241 1606 860 985 4213 851 374 2715 1927 1725 399 977 M14059 GO_NEGATIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BINDING.html Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 84/229 Gene Ontology BP GO:0051100 0.00504677933288309 0.0252817593649443 2070 1662.54545454545 1242 0.000459853992333026 261 1.26941775279994 1.36642084480513 1 7.69607191180342 2070 497 976 546 261 4601 2310 889 2196 1242 2700 978 M11343 GO_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_ARREST.html A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). 85/219 Gene Ontology BP GO:0007050 0.0361722717531193 0.0973046684529161 1245 1247.63636363636 1243 0.00334373408998764 218 1.3152677224318 1.36804547209019 1 5.05178123374943 1243 218 1767 432 814 2307 2013 1603 965 1250 1112 979 M11195 GO_VESICLE_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_TARGETING.html The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. 62/125 Gene Ontology BP GO:0006903 0.00374715109855892 0.0204682618242459 4150 1755.36363636364 1244 0.000341231699649226 41 1.15399425547617 1.24836586100728 1 7.39809167695736 4149 41 2351 500 213 1067 3136 2829 506 1244 3273 980 M10300 GO_REGULATION_OF_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATURATION.html Any process that modulates the frequency, rate or extent of cell maturation. 10/24 Gene Ontology BP GO:1903429 0.000342377718076665 0.00366281047241925 1335 1309.09090909091 1246 3.11300920585502e-05 53 1.69565542546603 1.69565542546603 1 15.6803299958115 1333 1499 1246 1018 3923 1576 1829 53 546 718 659 981 M10785 GO_LOOP_OF_HENLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOOP_OF_HENLE_DEVELOPMENT.html The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. 8/16 Gene Ontology BP GO:0072070 0.00790903541868625 0.0346092586912415 545 1305.54545454545 1246 0.000793732600956646 142 1.29994081892301 1.29994081892301 1 7.20815077612637 541 1246 3633 1320 2012 333 142 337 3141 1496 160 982 M13079 GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 41/98 Gene Ontology BP GO:0060998 0.0207442781618856 0.0675425550530398 595 1226.81818181818 1246 0.00190386383593821 593 1.57914678242171 1.57914678242171 1 7.01572242919629 593 783 1099 1340 595 2150 1812 1257 1749 1246 871 983 M15182 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. 479/1288 Gene Ontology BP GO:0045944 0.0157000753817444 0.0559808131074437 1250 1328.63636363636 1246 0.00143756815581676 506 1.2715427276925 1.34076287450499 1 6.04267058777244 1136 2370 909 1493 506 2026 1246 841 1598 1240 1250 984 M10366 GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. 5/17 Gene Ontology BP GO:0031953 0.00537774774150488 0.0263107299934743 1180 1603 1247 0.000539080631663046 137 1.82051220676583 1.82051220676583 1 10.9174542875062 1802 1505 3574 1247 876 3021 2872 245 137 1177 1177 985 M13935 GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 41/88 Gene Ontology BP GO:0043535 0.0368480036929113 0.0987220318212275 855 1209.63636363636 1247 0.00340727686644407 387 1.30902358003544 1.30902358003544 1 4.99659193277976 852 387 1810 647 818 2113 774 1705 1450 1247 1503 986 M16905 GO_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_EFFECTOR_PROCESS.html Any process of the immune system that can potentially contribute to an immune response. 252/940 Gene Ontology BP GO:0002252 0.0839184282471183 0.158445571591463 960 1472.27272727273 1249 0.00793650793650794 930 1.1797656430836 1.27295521372161 1 3.58309270368892 960 2043 1018 1924 1728 2495 951 930 1194 1249 1703 987 M11704 GO_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DIFFERENTIATION.html The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 43/108 Gene Ontology BP GO:0045446 0.012006674159025 0.0460816150833625 480 1531.54545454545 1251 0.00109751878329604 343 2.23625825089404 2.23625825089404 1 11.3445990560711 477 2704 592 2816 3460 819 343 1251 1568 2135 682 988 M10094 GO_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. 57/154 Gene Ontology BP GO:0016358 0.00610397582719909 0.0288602441605757 1390 1342 1252 0.000556452508733905 141 1.4165604383956 1.53242641020395 1 8.27901080242081 1387 611 520 141 1886 3536 3178 1252 647 178 1426 989 M12741 GO_REGULATION_OF_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBRINOLYSIS.html Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. 4/20 Gene Ontology BP GO:0051917 0.053973528030486 0.129709674247177 1255 1532.81818181818 1252 0.00553310838128386 390 1.72130338621463 1.72130338621463 1 5.7956453588257 1252 2036 3954 1426 2431 726 390 833 1929 1095 789 990 M10812 GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 108/272 Gene Ontology BP GO:0071216 0.00312342352537073 0.0179653064479894 915 1357.09090909091 1253 0.000284351527495502 457 1.39082793350673 1.39082793350673 1 9.21545437024872 913 1678 457 1232 1380 2705 982 602 2112 1253 1614 991 M11314 GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS.html Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 6/12 Gene Ontology BP GO:0050930 0.0800446273938716 0.158445571591463 820 1583.27272727273 1253 0.00830830547769606 491 0.53602107158688 0.594898769081393 1 1.6279616225241 818 1060 3728 1797 1253 491 804 1745 1747 3220 753 992 M12731 GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. 95/268 Gene Ontology BP GO:0006109 0.0535474601198108 0.12875238598461 1255 1486.09090909091 1253 0.00499063721293539 603 1.38865035931986 1.38865035931986 1 4.69255688056142 928 603 1255 1222 998 3102 1775 1113 1563 2535 1253 993 M15379 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. 59/148 Gene Ontology BP GO:1903426 0.0880202729051892 0.164391845172483 1800 1724.18181818182 1254 0.0083411559154994 753 1.2313228060909 1.29171715701373 1 3.66489499619278 1798 1090 1187 753 1254 4110 2854 877 1433 1139 2471 994 M14102 GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 37/103 Gene Ontology BP GO:0045912 0.00270001367834039 0.0162175465828388 1285 1425.63636363636 1256 0.000245757550272564 169 1.66956475338577 1.66956475338577 1 11.3440238691741 1285 875 552 994 169 3891 2370 1435 884 1971 1256 995 M14322 GO_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULOGENESIS.html The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. 48/94 Gene Ontology BP GO:0001570 0.0839184282471183 0.158445571591463 1000 1506.45454545455 1257 0.00793650793650794 444 1.8297518844879 1.8297518844879 1 5.55718050056835 999 778 1205 444 1852 2217 1257 3384 667 1462 2306 996 M14347 GO_REGULATION_OF_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. 44/107 Gene Ontology BP GO:0006885 0.0401113505675077 0.105218644454767 1095 1478.27272727273 1257 0.00371471888126253 436 1.63683128916386 1.80389653778312 1 6.07587508281719 1095 1929 747 1316 4271 1257 1503 828 436 838 2041 997 M15752 GO_HETEROCHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. 3/13 Gene Ontology BP GO:0070828 0.00696365565855887 0.0313486294765926 1125 1812.09090909091 1257 0.000698557401240119 140 0.382632072991965 -0.382632072991965 -1 2.18410404119249 1124 1257 4452 1738 3379 167 251 1830 1251 4344 140 998 M13495 GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 356/869 Gene Ontology BP GO:0051347 0.0839184282471183 0.158445571591463 950 1366.18181818182 1258 0.00793650793650794 599 1.41500709942374 1.43608981934346 1 4.29754980862381 950 1301 1258 843 1689 3310 1013 1720 1062 1283 599 999 M14525 GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. 27/57 Gene Ontology BP GO:0048635 0.0808829079370444 0.158445571591463 2265 1635.18181818182 1258 0.00763811225121466 456 0.430034382727536 -0.474427487075671 -1 1.30606707186892 2263 529 1843 1258 1203 456 1114 1650 2805 4035 831 1000 M10486 GO_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical. 427/1214 Gene Ontology BP GO:0048878 1.36765151537161e-08 9.07143712267199e-07 570 1116 1260 1.24331956715796e-09 70 1.36576935669784 1.56566751074928 1 31.3248209899839 568 1260 70 1067 1414 1731 1147 1304 1570 479 1666 1001 M12960 GO_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 20/45 Gene Ontology BP GO:0036314 0.0108829438219597 0.0432245578831127 3820 1944.81818181818 1260 0.000994286845833479 151 1.34688065758334 1.61212542072576 1 6.97487611339645 3817 534 1260 151 407 2624 3507 3895 258 1149 3791 1002 M12064 GO_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION.html The controlled release of a substance by a cell or a tissue. 309/906 Gene Ontology BP GO:0046903 2.57831406716041e-05 0.000520483139731556 2670 1973.27272727273 1262 2.34394934953634e-06 200 1.30831932517043 1.47664020333343 1 16.3068603826693 2667 684 200 659 1262 3707 3804 2043 1201 1056 4423 1003 M13075 GO_SOMITOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITOGENESIS.html The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 32/100 Gene Ontology BP GO:0001756 0.00511603321625522 0.0254322721874443 1455 1066.27272727273 1262 0.000466179024912221 263 1.73672985817872 1.91021908880517 1 10.5122408483597 1454 1276 945 1262 263 1668 1336 367 866 976 1316 1004 M10972 GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. 10/28 Gene Ontology BP GO:0033032 0.062159611802843 0.142662915274642 885 1458.36363636364 1264 0.00581715140674669 422 2.24458518468169 2.24458518468169 1 7.20533133150508 884 3188 1623 2203 2656 966 686 1264 422 1678 472 1005 M14156 GO_DRUG_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_METABOLIC_PROCESS.html The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. 15/89 Gene Ontology BP GO:0017144 0.000792383827342168 0.00695133982527408 1285 1331.72727272727 1267 7.20608516143008e-05 183 1.80282382826021 -1.59195221079983 -1 14.7672004902811 1284 1390 355 1267 183 2137 1116 3095 916 963 1943 1006 M12601 GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 278/886 Gene Ontology BP GO:0032870 5.1734796640791e-06 0.000133447033779551 1035 1309.18181818182 1268 4.70317439089007e-07 168 1.34472971390161 1.44688860195655 1 19.7778607518922 1033 919 168 469 1268 2269 1466 2438 1826 1023 1522 1007 M15779 GO_LYMPH_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. 9/28 Gene Ontology BP GO:0001945 0.0128591551883025 0.0488518843315876 1270 1941.63636363636 1268 0.00129341779511608 202 1.0923235667937 1.0923235667937 1 5.43626400650927 1268 975 4456 2128 3974 1217 908 861 3742 1627 202 1008 M10171 GO_OLIGOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 33/71 Gene Ontology BP GO:0009311 0.0634873934350817 0.145136370122641 1270 1222 1269 0.00594519296586265 71 2.03169131057769 2.03169131057769 1 6.46435074304346 1269 71 827 106 2771 2272 1673 867 245 1756 1585 1009 M15023 GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of glia cell differentiation. 37/97 Gene Ontology BP GO:0045685 0.0292992386122384 0.0847202264108869 370 1321.45454545455 1271 0.00269971591243652 270 0.939024370733805 0.939024370733805 1 3.82106216354635 369 1370 1271 1383 3451 510 270 651 2279 2642 340 1010 M10168 GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of mitosis. 24/63 Gene Ontology BP GO:0045840 0.030759606773662 0.0881199230906241 2110 1552.18181818182 1273 0.00283620798051095 514 1.84385386856247 2.09876468382849 1 7.38338782442929 2109 1590 714 1035 1273 3643 1922 1047 514 746 2481 1011 M15637 GO_PEPTIDE_HORMONE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_PROCESSING.html The generation of a mature peptide hormone by posttranslational processing of a prohormone. 10/44 Gene Ontology BP GO:0016486 0.0409892357925078 0.106677702794066 630 1442.45454545455 1275 0.00379758719895449 419 1.74485001602008 1.74485001602008 1 6.437224967882 751 2318 2083 1811 3719 626 419 629 1275 1714 522 1012 M14825 GO_BODY_FLUID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_FLUID_SECRETION.html The controlled release of a fluid by a cell or tissue in an animal. 42/126 Gene Ontology BP GO:0007589 0.0356720668315012 0.0966309254951343 1345 1467.72727272727 1278 0.00329672316107612 514 1.30824551215551 1.4470217221523 1 5.03979453088453 1341 514 734 667 2847 1130 1189 2282 1971 1278 2192 1013 M12232 GO_FATTY_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. 28/61 Gene Ontology BP GO:0035337 0.00834629178130857 0.0360470048163159 165 1449.27272727273 1279 0.00076164771704981 163 0.722840167654169 -0.722840167654169 -1 3.9596355010936 1279 717 2978 2682 342 164 791 1320 2065 3441 163 1014 M12603 GO_RESPONSE_TO_PROSTAGLANDIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 26/107 Gene Ontology BP GO:0034694 0.0119109716140028 0.0459324262490158 950 1326.54545454545 1279 0.0010887228736016 400 1.08918898596586 1.08918898596586 1 5.53130788313599 948 400 591 956 902 1682 1279 1843 1796 2467 1728 1015 M16270 GO_DEFENSE_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_FUNGUS.html Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. 18/101 Gene Ontology BP GO:0050832 0.0179603220486607 0.0616332411470299 1145 1620.27272727273 1279 0.00164624038440413 486 1.51746024606229 1.51746024606229 1 6.97069878573859 1145 957 1034 1279 557 2871 1626 4349 1306 2213 486 1016 M10925 GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of neuron differentiation. 181/480 Gene Ontology BP GO:0045666 0.137906800572145 0.237500472943794 860 1730.54545454545 1284 0.0133995876163242 859 1.67592707888596 1.67592707888596 1 3.97173618669473 859 3203 998 2538 2340 2287 1255 1152 2052 1284 1068 1017 M14851 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell migration. 78/152 Gene Ontology BP GO:0010634 0.0200198407814266 0.0659614325140451 1875 1664.27272727273 1284 0.0018367613779419 656 1.5850576109878 1.5850576109878 1 7.10387801679612 1871 932 656 837 1881 3322 2347 1284 894 1109 3174 1018 M12292 GO_KIDNEY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. 15/30 Gene Ontology BP GO:0061440 2.99662972252812e-05 0.000565583406573092 380 1090.81818181818 1285 2.72424594593853e-06 212 1.85748458485995 1.85748458485995 1 22.8971830363702 376 1285 212 589 1403 1516 1949 2346 493 473 1357 1019 M13386 GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 64/164 Gene Ontology BP GO:0016051 0.00968677159379744 0.0395564472383478 4320 2125.63636363636 1285 0.000884517089887096 375 1.74628970717482 1.87313864521432 1 9.2985222197609 4316 1008 1063 1156 375 1737 4566 3477 631 1285 3768 1020 M14598 GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. 15/30 Gene Ontology BP GO:0061437 2.99662972252812e-05 0.000565583406573092 380 1091.72727272727 1286 2.72424594593853e-06 213 1.85748458485995 1.85748458485995 1 22.8971830363702 377 1286 213 590 1404 1517 1950 2345 494 475 1358 1021 M13368 GO_GRANULOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_MIGRATION.html The movement of a granulocyte within or between different tissues and organs of the body. 33/100 Gene Ontology BP GO:0097530 0.0274385329486511 0.0810930034885979 815 1554.18181818182 1288 0.00252607683856603 520 1.43294747121644 1.43294747121644 1 5.93429136258977 815 2417 933 2210 3251 2062 1288 520 827 1761 1012 1022 M10247 GO_LENS_FIBER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. 23/49 Gene Ontology BP GO:0070306 0.00945570215137374 0.0390247334122918 1370 1225.72727272727 1289 0.00086332631277053 93 1.38989324121763 1.38989324121763 1 7.43181471729154 1367 93 1772 710 370 1707 919 2792 1364 1289 1100 1023 M10483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. 23/50 Gene Ontology BP GO:0048662 0.0839184282471183 0.158445571591463 1320 1454.90909090909 1290 0.00793650793650794 662 1.33987647360822 1.45658683067777 1 4.06936889932657 1317 881 1009 662 3318 1358 816 2702 692 1290 1959 1024 M13107 GO_REGULATION_OF_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ORGANIZATION.html Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 69/183 Gene Ontology BP GO:0050807 0.00760307759225456 0.0335607766723793 590 1079.18181818182 1290 0.000693589203945698 366 1.47585693480557 1.51721991470885 1 8.25844860183724 587 1314 546 366 1914 1538 1290 1883 574 418 1441 1025 M16865 GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. 82/178 Gene Ontology BP GO:0071901 0.00176586126325616 0.0117945758525033 1290 1305.09090909091 1290 0.000160661841064452 132 1.33783265091405 1.33859273349078 1 9.79236523831953 1290 2155 1197 1338 2763 1407 961 132 1581 1169 363 1026 M11065 GO_PRIMITIVE_STREAK_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMITIVE_STREAK_FORMATION.html The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. 8/19 Gene Ontology BP GO:0090009 0.0145928779828896 0.0531409666467109 660 1353 1292 0.00146896015618977 325 1.46584243959724 1.46584243959724 1 7.09183139598507 660 1292 3681 1509 3033 325 366 400 1706 1497 414 1027 M16157 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. 21/60 Gene Ontology BP GO:0040018 0.0839184282471183 0.158445571591463 1565 1369.45454545455 1295 0.00793650793650794 169 1.60961787589834 1.60961787589834 1 4.88860656414792 1564 639 1804 542 1295 2797 2626 1521 169 1235 872 1028 M14274 GO_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_SECRETION.html The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 23/87 Gene Ontology BP GO:0050663 0.00186350454989596 0.0122901301493849 1750 1633.81818181818 1296 0.000169553172837454 137 2.25789245362561 2.25789245362561 1 16.3736191880745 1749 2845 1027 1057 3086 2023 3105 137 393 1296 1254 1029 M14188 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 68/153 Gene Ontology BP GO:0007179 0.00223668283924739 0.0141483902215608 1300 1417.18181818182 1297 0.000203541823500141 151 1.2463058918098 1.2283752036703 1 8.7485806149445 1297 1216 937 1056 151 3161 1822 1691 1512 414 2332 1030 M15838 GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 17/27 Gene Ontology BP GO:0033598 0.00754356792441215 0.0334205972071046 1335 1227.27272727273 1297 0.000688141716117971 323 1.20968048448593 1.20968048448593 1 6.7773526301175 1331 643 1375 447 323 2054 1103 2567 1297 1043 1317 1031 M12855 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. 3/14 Gene Ontology BP GO:0046929 0.0765897756730953 0.158445571591463 1170 1760.90909090909 1299 0.00793650793650794 11 1.77228865595639 1.77228865595639 1 5.38265763994863 1169 3730 3969 1955 1711 1299 1159 2791 11 984 592 1032 M10359 GO_NATURAL_KILLER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. 7/15 Gene Ontology BP GO:0001779 0.00590174155227878 0.0281332505413043 1480 1382.90909090909 1302 0.000591747413797981 154 1.21171025470624 1.21171025470624 1 7.13273731238099 1477 154 3572 475 3691 2327 401 257 163 1393 1302 1033 M13280 GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 312/759 Gene Ontology BP GO:0010563 0.0504750276172946 0.123611655816039 1180 1403.27272727273 1302 0.00469742773279699 689 1.2256961719302 1.31474223304499 1 4.22422931392278 1179 1302 1029 1411 1312 3065 1411 689 1180 1728 1130 1034 M15447 GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 64/136 Gene Ontology BP GO:0072329 0.0851071750250703 0.159980815239434 790 1600.18181818182 1302 0.00805360831211274 335 0.736186088956347 -0.736186088956347 -1 2.2241847305506 786 1150 2310 1621 1302 335 2167 1192 1852 4275 612 1035 M15665 GO_ASPARTATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. 5/12 Gene Ontology BP GO:0006531 0.017446550587998 0.0603609049031853 1425 1631.18181818182 1302 0.00175850554222891 518 1.23889395501682 -1.23889395501682 -1 5.73366195105226 1422 984 4435 1486 574 1144 2932 1302 1938 1208 518 1036 M15523 GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. 229/638 Gene Ontology BP GO:0002683 4.46014993698562e-05 0.000764150411713071 605 1329.45454545455 1303 4.05476396545013e-06 224 1.29046579625125 1.31928682092908 1 15.2674185292817 602 1759 224 1573 1932 2368 1303 1173 1113 802 1775 1037 M15999 GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 312/759 Gene Ontology BP GO:0045936 0.0203717175509151 0.0667979410938551 1415 1382.36363636364 1303 0.00186934903155723 449 1.2256961719302 1.31474223304499 1 5.46783610548437 1180 1303 1030 1412 1313 3066 1412 449 1181 1729 1131 1038 M13834 GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. 3/19 Gene Ontology BP GO:0060707 0.000416052063590109 0.00421775050491021 1605 1831.63636363636 1305 4.16129978815354e-05 61 0.896585420808603 0.896585420808603 1 8.08253746722173 1601 1198 4141 1285 61 2317 1305 419 2717 3846 1258 1039 M12054 GO_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_PRECURSOR_CELL_PROLIFERATION.html The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. 49/155 Gene Ontology BP GO:0061351 0.016780677282501 0.0585809658816934 1890 1545.63636363636 1306 0.00153727790662068 537 1.46211475462341 1.53717781622344 1 6.83888367719471 1888 938 1037 919 537 1958 1306 3975 2362 604 1478 1040 M13341 GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of chondrocyte differentiation. 22/71 Gene Ontology BP GO:0032330 0.0679894057974643 0.152374161760971 1310 1474.18181818182 1306 0.00638056601996469 629 1.19573689924984 1.13106540002451 1 3.70861756702342 1306 2296 2069 1529 1112 1827 981 2511 629 697 1259 1041 M13385 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of activation. 163/554 Gene Ontology BP GO:0050867 0.00455258849778902 0.0235472828164902 1560 1530.54545454545 1306 0.000414730619925472 488 1.29674666454236 1.31867532612399 1 8.01369046493885 1557 1306 488 625 847 3572 2079 1761 1074 608 2919 1042 M11415 GO_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 331/883 Gene Ontology BP GO:0001775 0.00103161593086527 0.00821576803946392 1025 1468.09090909091 1307 9.38272718391204e-05 379 1.31937013047562 1.37630397411148 1 10.4436718273655 1021 1353 379 1307 1603 3036 1859 1273 1138 864 2316 1043 M11802 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 885/2327 Gene Ontology BP GO:0010628 0.0313341465035871 0.0889269206700214 1310 1913.45454545455 1308 0.00317849415735408 787 1.28421601310367 1.34422735288701 1 5.12311714510484 1308 2369 3808 2550 787 3673 1272 903 2101 993 1284 1044 M10370 GO_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_BINDING.html Any process that modulates the frequency, rate or extent of protein binding. 119/277 Gene Ontology BP GO:0043393 0.0019982310027041 0.0129578024379262 2070 1753.09090909091 1309 0.000181822570987267 143 1.29350740963885 1.36624508171889 1 9.26735709625948 2067 1309 1069 1046 143 4072 2958 905 1794 1053 2868 1045 M15544 GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH.html Any process that modulates the extent of cell growth. 66/153 Gene Ontology BP GO:0061387 0.0556058651466811 0.132331128588437 1310 1701.09090909091 1309 0.00518756009797128 508 1.27582732229686 1.35660842411959 1 4.25364061115907 1309 508 799 676 2472 3586 1299 3491 1976 601 1995 1046 M12182 GO_BIOTIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOTIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. 6/13 Gene Ontology BP GO:0006768 0.000917991852218442 0.00765212956885139 1490 1708.27272727273 1311 9.18371291909625e-05 94 0.379456171569104 -0.386314968061118 -1 3.0480998611014 1487 157 3865 869 94 660 1311 1309 4000 3430 1609 1047 M15427 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 10/30 Gene Ontology BP GO:0071354 0.000854017173957034 0.00723578407738622 1480 1273.09090909091 1311 7.76680795313739e-05 82 0.653874098340854 0.653874098340854 1 5.31275170499675 1476 563 1446 866 82 1405 538 1594 456 4267 1311 1048 M13373 GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. 24/58 Gene Ontology BP GO:0030514 0.00289409334805056 0.0168809992650738 1265 1490.90909090909 1312 0.000263446140503788 170 1.65516305351136 1.65516305351136 1 11.136769024264 1261 2348 1312 1749 3590 2737 723 170 375 748 1387 1049 M14400 GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein homooligomerization. 10/19 Gene Ontology BP GO:0032462 0.00190173113169448 0.0125067105445573 385 1229.54545454545 1312 0.000173034274952364 139 1.86280643978199 1.86280643978199 1 13.4549191176005 385 1661 1482 1559 4443 308 205 139 1312 1704 327 1050 M16107 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 559/1448 Gene Ontology BP GO:0051241 0.0199100597799674 0.0658568552552914 560 1405.81818181818 1314 0.00200907268566268 246 1.37159976116148 1.42514032758965 1 6.15079474882733 557 460 4509 583 1423 2277 1314 1373 1140 246 1582 1051 M11296 GO_INORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSPORT.html The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 33/147 Gene Ontology BP GO:0015698 0.0543880769348738 0.130435868392882 1320 1335.18181818182 1316 0.00507101001505384 244 1.97610902127171 1.97610902127171 1 6.63539105670057 1316 1846 1399 1728 1507 3019 1111 711 244 1016 790 1052 M12737 GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS.html Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. 14/57 Gene Ontology BP GO:0036473 0.00481931740080229 0.0245750994003292 2020 1155.90909090909 1317 0.000439082462083171 164 2.24458518468169 2.24458518468169 1 13.7130979120231 700 1971 1317 2018 2034 269 607 217 1399 2019 164 1053 M15578 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. 9/31 Gene Ontology BP GO:2000353 0.0090932462517462 0.0378654191451638 1625 1415 1317 0.00091306711718046 385 1.700555425947 1.700555425947 1 9.17748045635745 451 1403 4427 1317 385 1307 576 1621 406 1623 2049 1054 M16087 GO_SOMITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITE_DEVELOPMENT.html The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 39/123 Gene Ontology BP GO:0061053 0.0308331842686588 0.088151770048881 1810 1428.90909090909 1321 0.00284308978442813 743 1.73672985817872 1.91021908880517 1 6.95339408547188 1809 1321 1001 1478 743 2663 2041 750 924 1161 1827 1055 M12886 GO_REGULATION_OF_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCRINE_PROCESS.html Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 19/62 Gene Ontology BP GO:0044060 0.0801387352097418 0.158445571591463 805 1657.45454545455 1324 0.00756509583393781 420 0.520514923867979 0.524018707901681 1 1.58086755339064 804 2385 1324 1825 2888 420 435 1224 2630 3593 704 1056 M10691 GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION.html A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. 8/20 Gene Ontology BP GO:0060231 0.00375229933467146 0.0204722982501523 1325 1345.63636363636 1325 0.00037586503203463 201 1.38916827744188 -1.38916827744188 -1 8.90530704108778 1325 2180 3618 791 1529 808 594 201 1945 1494 317 1057 M13554 GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. 61/118 Gene Ontology BP GO:0048013 0.0274987946444299 0.0811070991099343 1170 1676.63636363636 1325 0.00253169566203183 521 1.38140788003774 1.50746593378376 1 5.72045371776847 1166 1682 1454 1260 702 3888 3021 2823 601 521 1325 1058 M11642 GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 6/27 Gene Ontology BP GO:0034035 0.0765897756730953 0.158445571591463 1730 1538.27272727273 1326 0.00793650793650794 53 1.82051220676583 1.82051220676583 1 5.52911846805698 1729 671 3780 478 1326 2599 2474 1049 53 1312 1450 1059 M12409 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 16/44 Gene Ontology BP GO:0033144 0.018615530386134 0.0630441631817949 1655 1377.54545454545 1326 0.00170681266094632 425 1.70820157422404 1.70820157422404 1 7.78316247380606 1652 649 1776 924 566 620 425 3385 1722 2108 1326 1060 M11245 GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 22/69 Gene Ontology BP GO:0051349 0.364489668552258 0.484490561433763 1260 2117.63636363636 1327 0.0403738900721724 1034 1.14796226859257 -1.29245240179828 -1 1.37136115962293 2981 1327 1256 1034 2166 1297 4585 3778 2359 1260 1251 1061 M13821 GO_DISTAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISTAL_TUBULE_DEVELOPMENT.html The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. 6/19 Gene Ontology BP GO:0072017 0.0285222732142116 0.0832886254928204 1860 1698.09090909091 1327 0.00288951100886666 557 1.04642253103459 -0.792904243146179 -1 4.28748370448631 1858 907 4138 617 1764 2727 799 557 2809 1327 1176 1062 M12436 GO_GLYCOGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. 11/33 Gene Ontology BP GO:0005978 0.0139444362747838 0.0518366834458137 825 1372.18181818182 1328 0.00127578306911314 265 1.70956702222945 1.70956702222945 1 8.34101854911085 824 2973 1978 1328 470 1650 1094 1416 265 1788 1308 1063 M11223 GO_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTATIC_PROCESS.html Any biological process involved in the maintenance of an internal steady state. 683/1868 Gene Ontology BP GO:0042592 0.0143112156592881 0.0526380793457477 705 1551.18181818182 1329 0.00144042246881958 220 1.37501929046617 1.50483865863466 1 6.67397653810428 703 2038 3712 1312 1249 2380 1066 1329 1562 220 1492 1064 M15244 GO_GLUCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. 11/33 Gene Ontology BP GO:0009250 0.0139444362747838 0.0518366834458137 825 1375.72727272727 1329 0.00127578306911314 266 1.70956702222945 1.70956702222945 1 8.34101854911085 825 2974 1979 1329 471 1651 1095 1424 266 1810 1309 1065 M10782 GO_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDLIMB_MORPHOGENESIS.html The process in which the anatomical structures of the hindlimb are generated and organized. 16/54 Gene Ontology BP GO:0035137 0.00315007162839935 0.0180342571771371 3150 1779.09090909091 1332 0.000286781011193589 186 1.30044001605611 -1.08512734091638 -1 8.60834307980875 3147 1332 939 729 186 2632 3774 4118 270 240 2203 1066 M13528 GO_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neuroblast proliferation. 14/44 Gene Ontology BP GO:1902692 0.00796100618466956 0.0346744387574304 1120 1580.81818181818 1334 0.00072636008981 78 0.380363125438843 -0.409451214346716 -1 2.1079275793008 1116 1334 2814 1511 3981 78 164 1374 977 3764 276 1067 M12252 GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of muscle contraction. 27/61 Gene Ontology BP GO:0045933 0.014318736638742 0.0526380793457477 1055 1333.90909090909 1335 0.00131025349926771 469 1.37984070223529 1.45987044046083 1 6.69737838362866 1055 2254 620 1443 2326 1734 836 1878 723 469 1335 1068 M14628 GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that modulates the frequency, rate or extent of lamellipodium organization. 34/81 Gene Ontology BP GO:1902743 0.0422910025040766 0.109077806722957 1335 1659.63636363636 1335 0.0039205950109915 327 1.61973478639426 1.61973478639426 1 5.91623204989605 1335 1894 1278 569 4630 3113 2092 641 327 631 1746 1069 M15300 GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a humoral immune response. 6/19 Gene Ontology BP GO:0002922 0.0765897756730953 0.158445571591463 1585 1468.45454545455 1336 0.00793650793650794 188 1.11882204112119 1.11882204112119 1 3.39799952283645 1584 311 4382 477 2367 1456 1264 1141 188 1336 1647 1070 M15418 GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. 25/55 Gene Ontology BP GO:2000249 0.0613341482770523 0.141608379139907 1165 2039.36363636364 1336 0.00573763278428257 771 2.00022724136183 2.00022724136183 1 6.44538337455148 3485 1164 1336 1332 1069 3653 2977 1163 771 1386 4097 1071 M12726 GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 19/52 Gene Ontology BP GO:0051491 0.0582676224312386 0.136841968107355 260 1605.54545454545 1337 0.00544278363417296 260 0.809062022992761 0.809062022992761 1 2.65272687520357 260 2349 1111 2216 2090 998 832 806 3424 2238 1337 1072 M15516 GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION.html Any process that modulates the frequency, rate or extent of interferon-gamma secretion. 6/15 Gene Ontology BP GO:1902713 0.00879407809344739 0.0370529497491828 680 1792.18181818182 1337 0.000882907427974233 147 1.35593454827845 1.35593454827845 1 7.36612984739513 679 2655 4416 3534 1993 730 147 332 3427 1337 464 1073 M14010 GO_RESPONSE_TO_CARBOHYDRATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CARBOHYDRATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 106/256 Gene Ontology BP GO:0009743 0.0316540445671697 0.089506534059299 465 1351.45454545455 1338 0.00291989819713708 463 1.36806700737247 1.46001298671813 1 5.44297168486441 463 1514 1594 1138 755 2189 1415 1338 2200 1238 1022 1074 M14645 GO_LEUKOCYTE_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CELL_CELL_ADHESION.html The attachment of a leukocyte to another cell via adhesion molecules. 152/415 Gene Ontology BP GO:0007159 0.000378004475688245 0.00392634179109736 1155 1448.36363636364 1338 3.43699491024194e-05 318 1.51432253800451 1.57520090864503 1 13.830038455833 1154 2658 318 1575 2240 2162 1338 1133 1096 699 1559 1075 M15987 GO_O_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_GLYCAN_PROCESSING.html The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. 22/65 Gene Ontology BP GO:0016266 0.00326388889419547 0.0185941547677909 3930 2168.45454545455 1339 0.00029715829409239 96 1.22766042405918 -1.18882366062725 -1 8.06469780051896 3926 96 919 389 189 3629 4168 3333 1339 1272 4593 1076 M16361 GO_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 243/581 Gene Ontology BP GO:0006979 2.24531371347763e-05 0.00046959421494039 1340 1439.45454545455 1339 2.04121511764788e-06 194 1.38211991689272 1.49927314773099 1 17.4611343713215 1339 1205 194 1405 555 3130 1069 1934 1851 927 2225 1077 M13647 GO_BILE_ACID_AND_BILE_SALT_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_AND_BILE_SALT_TRANSPORT.html The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/63 Gene Ontology BP GO:0015721 0.0880671448449464 0.164413250307634 540 1432.27272727273 1340 0.00834578939763526 125 1.25240526293404 1.25240526293404 1 3.7273757672778 536 125 1074 1311 2704 1340 464 2317 2377 1945 1562 1078 M16007 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. 10/23 Gene Ontology BP GO:1903427 0.0608076665618968 0.140721239830686 1950 1477.36363636364 1342 0.00568694889963003 138 1.35593454827845 1.35593454827845 1 4.38330999500126 1950 138 971 1127 1061 3059 2361 767 1342 1718 1757 1079 M15281 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT.html Any process that modulates the frequency, rate or extent of actin filament-based movement. 25/71 Gene Ontology BP GO:1903115 0.110787678333454 0.198375314501437 1420 1725.63636363636 1343 0.0106177063139031 399 1.88154097255481 -2.12764452129208 -1 5.0173556647522 1416 2491 1028 2520 4582 399 1152 1343 2164 792 1095 1080 M15527 GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of JUN kinase activity. 41/121 Gene Ontology BP GO:0043507 0.0203410674227029 0.0667445767092648 395 1305.54545454545 1344 0.00186651007000207 393 1.38989324121763 1.38989324121763 1 6.20215116254757 393 1842 1679 1344 2487 716 1110 448 1759 2095 488 1081 M16562 GO_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. 767/2129 Gene Ontology BP GO:0009888 3.85776673290428e-05 0.000686268618424314 755 1623.81818181818 1345 3.85783370517934e-06 23 1.43946555052479 1.48979342887055 1 17.2853090994895 753 1201 4581 450 2045 2975 1686 1345 934 23 1869 1082 M12515 GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 7/25 Gene Ontology BP GO:0070875 0.111991094994812 0.200221276111248 975 1836.09090909091 1346 0.0118070934892104 861 0.495751951405708 0.593737096037431 1 1.31441260832023 971 1346 3922 1756 1421 1180 861 1167 2819 3509 1245 1083 M14816 GO_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_DISASSEMBLY.html A process that results in the breakdown of the extracellular matrix. 44/149 Gene Ontology BP GO:0022617 1.94749562962446e-06 5.94883040022789e-05 520 1145.72727272727 1346 1.77045213963543e-07 145 1.59341589756949 1.59341589756949 1 25.5576850678468 520 941 145 520 1366 2210 1346 1048 1388 1346 1773 1084 M16852 GO_ORGANELLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FUSION.html The creation of a single organelle from two or more organelles. 72/149 Gene Ontology BP GO:0048284 0.00776798197371433 0.0341217978277726 850 2191.54545454545 1346 0.000708686027502869 76 0.258487538396928 -0.26348791077706 -1 1.43935363900744 847 3972 3341 4270 1346 76 701 503 4124 4608 319 1085 M11135 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 43/148 Gene Ontology BP GO:0003073 0.0287554091476259 0.0836013554617577 1350 1588.09090909091 1347 0.00264893505254421 708 1.285087544559 1.35284506430154 1 5.25742102752945 1347 1154 708 1561 897 2600 2631 2833 818 812 2108 1086 M10285 GO_AMMONIUM_ION_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_METABOLIC_PROCESS.html The chemical reactions and pathways involving the ammonium ion. 66/208 Gene Ontology BP GO:0097164 0.0826743953526417 0.158445571591463 2350 1793.36363636364 1348 0.00781410930225122 610 1.2721464005771 -1.0248491474855 -1 3.86366437492982 2346 610 1229 1114 1215 3464 1653 2332 915 1348 3501 1087 M13653 GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. 12/31 Gene Ontology BP GO:0045879 0.0592127112347511 0.138014366597866 1875 1890.90909090909 1348 0.00553356158924757 116 1.55472545123558 1.55472545123558 1 5.07571955667077 1873 1040 1348 529 4625 4416 4051 731 116 384 1687 1088 M14938 GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase B. 16/37 Gene Ontology BP GO:0032148 0.104875400196418 0.189322116295478 1335 1494.81818181818 1349 0.0100214790185835 1008 1.45803702929599 1.45803702929599 1 4.00030511278322 1606 1333 1936 1765 1334 1742 1027 1997 1346 1008 1349 1089 M12033 GO_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_MEDIATED_IMMUNITY.html Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. 29/269 Gene Ontology BP GO:0019724 0.0466519266008847 0.116705223711157 745 1254.63636363636 1352 0.00433378215921023 368 1.19829162277717 1.27630745492374 1 4.24335498650029 743 2252 1431 1352 2770 768 368 697 1453 1565 402 1090 M12351 GO_RESPONSE_TO_TESTOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TESTOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. 24/66 Gene Ontology BP GO:0033574 0.00771531907273399 0.0339547170186767 3145 1817.09090909091 1352 0.000703864546143994 157 1.32747247712551 1.45524281358226 1 7.4025965621173 3144 399 737 312 326 3977 1794 4149 157 1352 3641 1091 M15291 GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of macrophage differentiation. 12/25 Gene Ontology BP GO:0045649 0.0238512358300509 0.0743230120529707 1355 1784 1355 0.00219216476937978 682 1.28983715113895 1.28983715113895 1 5.5269892697067 1355 1861 682 1280 4510 1248 1048 2798 2161 1887 794 1092 M10632 GO_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 32/93 Gene Ontology BP GO:0061035 0.0839184282471183 0.158445571591463 1360 1391 1358 0.00793650793650794 432 1.24975800731932 1.2147596599177 1 3.79566808345997 1359 1226 1540 917 1358 2386 1014 2790 432 574 1705 1093 M10865 GO_BETA_AMYLOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). 11/25 Gene Ontology BP GO:0050435 0.000252723948487503 0.00285325612616643 2985 1555.09090909091 1358 2.29775440636482e-05 24 1.93903046521627 1.93903046521627 1 18.7292978964099 2985 123 1358 24 46 3688 2776 2135 52 767 3152 1094 M10656 GO_SECRETION_BY_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION_BY_CELL.html The controlled release of a substance by a cell. 261/746 Gene Ontology BP GO:0032940 0.000990703530516556 0.00804317366908581 3235 2111 1359 9.01045404895989e-05 375 1.32906935898259 1.53257389758095 1 10.5669653960282 3231 994 375 822 1119 3040 4275 2327 1222 1359 4457 1095 M13399 GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. 10/30 Gene Ontology BP GO:0033630 0.0839184282471183 0.158445571591463 1980 1539.27272727273 1361 0.00793650793650794 79 1.75066070213174 1.75066070213174 1 5.31697089614237 1977 1400 982 357 4252 2610 1361 1354 79 726 1834 1096 M14190 GO_POSITIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GROWTH.html Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. 157/393 Gene Ontology BP GO:0045927 0.027219492402115 0.0805995556269259 2655 1882 1361 0.00250565608024974 287 1.4825773568945 1.51983653636881 1 6.15474185200901 2655 926 703 287 1361 2366 3869 3457 1026 741 3311 1097 M14644 GO_PEPTIDYL_TYROSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_MODIFICATION.html The modification of peptidyl-tyrosine. 90/243 Gene Ontology BP GO:0018212 0.0839184282471183 0.158445571591463 505 1201.72727272727 1361 0.00793650793650794 505 1.42512135962908 1.42512135962908 1 4.32826805521728 505 1424 1500 1618 1988 974 638 1467 1103 1361 641 1098 M16180 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 71/173 Gene Ontology BP GO:0090101 0.0309481007931267 0.0882629189081616 1380 1550.27272727273 1362 0.00285383903467227 448 1.25337488467066 1.33744201585055 1 5.01556861805089 1379 1149 1362 886 747 4337 2371 728 1440 448 2206 1099 M12384 GO_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that modulates the frequency, rate, or extent of a homeostatic process. 262/664 Gene Ontology BP GO:0032844 2.94815048088722e-05 0.000564283240835162 815 1362.63636363636 1364 2.68017271714674e-06 209 1.4533760430763 1.50293545054222 1 17.9212575039522 811 3370 209 2137 1994 1602 747 336 1861 1364 558 1100 M13125 GO_MIDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). 68/187 Gene Ontology BP GO:0030901 0.0465075208892776 0.116469481924982 4630 2052.27272727273 1364 0.00432007258189975 377 1.50997083522858 1.70114518208062 1 5.35209744373169 4628 1364 769 377 965 1810 4117 3153 717 940 3735 1101 M13086 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. 118/306 Gene Ontology BP GO:1904950 0.00287606358879906 0.0168180897264408 400 1511.36363636364 1365 0.000261802760660681 169 1.13331815951171 1.23100730078728 1 7.63250971178373 399 2444 1365 2493 1878 993 934 169 2855 2450 645 1102 M14020 GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 86/231 Gene Ontology BP GO:0072330 0.0572574962306411 0.135368812869288 780 1496.63636363636 1366 0.00534585020627762 720 0.98793629809518 -0.689781327980798 -1 3.25684196143893 777 769 847 1624 2998 1678 882 720 2078 2724 1366 1103 M14660 GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 10/35 Gene Ontology BP GO:0032660 0.161385165508919 0.258740097879113 1960 1901.18181818182 1366 0.0158730158730159 300 0.491253277415802 -0.412399639971444 -1 1.09484236801545 1959 300 2147 962 4085 787 1197 2711 1366 4068 1331 1104 M15106 GO_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 57/138 Gene Ontology BP GO:0010827 0.0201648447965506 0.0663069223727935 1230 1580.54545454545 1366 0.00185018905359284 588 1.4602498020544 1.4602498020544 1 6.53194138240154 1230 704 1366 1032 588 4631 2194 957 1473 1766 1445 1105 M10433 GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of endocytosis. 73/190 Gene Ontology BP GO:0045807 0.00128944194980845 0.00939855411767763 1370 1223.90909090909 1368 0.00011729075684727 392 1.49301870786156 1.49301870786156 1 11.4871726805542 664 1572 392 1368 2916 1836 1368 691 770 466 1420 1106 M13887 GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 14/43 Gene Ontology BP GO:0010800 0.0839184282471183 0.158445571591463 4190 2016.54545454545 1369 0.00793650793650794 37 2.34259311853386 2.34259311853386 1 7.11474211861035 4190 415 1103 273 2595 2721 3976 1369 37 917 4586 1107 M15366 GO_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. 76/209 Gene Ontology BP GO:0010001 0.0589858903341206 0.137762318320584 1170 1602.18181818182 1369 0.00551176736144284 606 1.365109098482 1.30886634746469 1 4.46079168532106 1167 606 1369 1053 1048 3491 1909 2757 921 1639 1664 1108 M12424 GO_NEGATIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 264/670 Gene Ontology BP GO:0051051 0.000890321312848868 0.00749375104253493 945 1613.72727272727 1371 8.09710747810463e-05 368 1.32059451770547 1.37310827410955 1 10.653617848907 943 2087 368 2055 3082 2236 1334 1201 2248 1371 826 1109 M10228 GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 15/28 Gene Ontology BP GO:0022011 0.024432580852359 0.075290790090591 760 2051.81818181818 1372 0.00224620158749212 657 0.328383142436055 0.387357711890374 1 1.40012774637848 756 3288 2745 3795 657 1147 1191 1164 3473 2982 1372 1110 M12169 GO_LATERAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. 4/14 Gene Ontology BP GO:0048368 0.0293668835420589 0.0848071781288422 1375 1644.27272727273 1372 0.00297623450857989 583 1.38975139692581 -1.38975139692581 -1 5.65280283448771 1372 912 3864 1165 769 1492 2458 1768 2612 1092 583 1111 M16809 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. 10/36 Gene Ontology BP GO:0010575 0.00856804410638389 0.036496723656826 2810 1942.63636363636 1372 0.000781963272415985 348 1.21693894800114 1.21693894800114 1 6.64137841643525 2810 656 1282 430 348 4259 3170 3057 1372 733 3252 1112 M14616 GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT.html The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 15/28 Gene Ontology BP GO:0032292 0.024432580852359 0.075290790090591 760 2144.45454545455 1373 0.00224620158749212 658 0.328383142436055 0.387357711890374 1 1.40012774637848 757 3289 2746 3796 658 1148 1192 1101 3474 4055 1373 1113 M10149 GO_LABYRINTHINE_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_DEVELOPMENT.html The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. 25/64 Gene Ontology BP GO:0060711 0.000285768541506871 0.00315910318622952 3675 2036 1375 2.59823334639783e-05 50 1.4787559468286 1.4787559468286 1 14.0352292576173 3671 86 1322 55 50 4241 2459 4328 231 1375 4578 1114 M14125 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that activates or increases the frequency, rate or extent of response to wounding. 85/245 Gene Ontology BP GO:1903036 0.000529074412189086 0.00511033915617286 1645 1709.81818181818 1375 4.81092446624098e-05 336 1.57133308458781 1.57133308458781 1 13.6679970321478 1644 1082 336 785 963 4048 2439 1375 1577 1251 3308 1115 M10470 GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. 25/70 Gene Ontology BP GO:0060688 0.0839184282471183 0.158445571591463 2330 1813.72727272727 1376 0.00793650793650794 90 1.66409842843252 1.66409842843252 1 5.05407067257677 2329 90 1359 164 3031 3001 1258 4408 424 1376 2511 1116 M15039 GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 31/65 Gene Ontology BP GO:0009066 0.0839184282471183 0.158445571591463 1945 1446.18181818182 1376 0.00793650793650794 649 1.13533089743152 -1.41448702878402 -1 3.44813894072974 1135 1376 1941 2240 1942 649 1952 1031 957 1667 1018 1117 M12495 GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 916/2298 Gene Ontology BP GO:0044093 0.0404128850598372 0.105770589251874 1675 1749.90909090909 1378 0.00411672054195047 261 1.35309435044093 1.44874379325436 1 5.01098055577205 1673 323 3918 261 918 3785 2285 1378 1145 591 2972 1118 M12499 GO_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPROUTING_ANGIOGENESIS.html The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. 25/83 Gene Ontology BP GO:0002040 0.0233551497304176 0.0731206744425684 1380 1226.45454545455 1380 0.00214607601492157 242 1.20313380481586 1.20313380481586 1 5.18781078279523 314 1935 1380 1590 3237 721 242 854 1552 1380 286 1119 M13433 GO_MESONEPHRIC_TUBULE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHRIC_TUBULE_MORPHOGENESIS.html The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. 24/83 Gene Ontology BP GO:0072171 0.00957683608759424 0.0392592104060817 3095 1756 1380 0.000874434630278351 150 1.6361024677156 1.69783601528402 1 8.73214828716137 3094 1380 702 341 373 4518 2172 3722 150 211 2653 1120 M16781 GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 180/463 Gene Ontology BP GO:0060249 0.000829376397398198 0.00713663895475481 1365 1616.27272727273 1382 7.54262935020103e-05 359 1.44097132135681 1.50872620322425 1 11.7407199955335 1365 2835 359 1531 1382 4440 1727 1710 872 425 1133 1121 M13132 GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. 132/319 Gene Ontology BP GO:0043523 0.0074419307811873 0.0330333504943142 1250 1452.18181818182 1385 0.000678838585059065 319 1.54926602398952 1.633306221861 1 8.70967958731549 1249 2988 812 1062 319 2474 1385 1412 1992 701 1580 1122 M10174 GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST.html Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. 6/28 Gene Ontology BP GO:0044144 0.0956179249911956 0.176032524081729 1320 1623.90909090909 1386 0.01 155 0.786366142286891 0.95274848874932 1 2.25184137754119 1319 155 3549 736 2094 1584 1369 1386 1656 2967 1048 1123 M11877 GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 31/72 Gene Ontology BP GO:0009064 0.00522448130397272 0.0257781792713553 1360 1358.81818181818 1386 0.000476084511049716 228 1.13533089743152 -1.41448702878402 -1 6.84675266520868 1358 713 1386 1593 1495 801 2908 228 2027 1665 773 1124 M10093 GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 54/171 Gene Ontology BP GO:0008277 0.0209980852710325 0.0680349685369184 985 1601.54545454545 1388 0.00192738390127747 665 1.11743867576902 1.23427015578298 1 4.95109705128149 985 2618 665 3155 1484 1296 1307 955 2105 1659 1388 1125 M11644 GO_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 180/425 Gene Ontology BP GO:0002521 0.0839184282471183 0.158445571591463 930 1414.27272727273 1388 0.00793650793650794 756 1.3237813502602 1.40701575051718 1 4.02048603909562 926 2089 908 1456 1231 2218 1755 1388 1208 756 1622 1126 M11394 GO_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 39/100 Gene Ontology BP GO:0005976 0.0584068101814515 0.1368918827221 1160 1846.90909090909 1389 0.00545614773609519 458 1.83047660507638 1.83047660507638 1 6.00060809262742 2208 1156 1929 771 1040 4417 3107 1389 458 1158 2683 1127 M15518 GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 25/58 Gene Ontology BP GO:0061001 0.0647653991276693 0.146900707449814 1390 1354.36363636364 1389 0.00606859046133566 683 1.61156951470423 1.61156951470423 1 5.09552365218646 683 1688 1389 1763 1092 1544 1536 1169 1726 1387 921 1128 M12994 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. 9/26 Gene Ontology BP GO:0032232 0.0747891079882797 0.158445571591463 600 1777.81818181818 1390 0.0077432231973239 441 1.19045135446987 1.19045135446987 1 3.6155465174851 600 1404 3991 1200 3631 906 441 1390 3594 1600 799 1129 M11956 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. 190/470 Gene Ontology BP GO:0032970 0.000149779952334273 0.00196448677595488 2300 1695.36363636364 1391 1.36172864176878e-05 143 1.28482572979582 1.29222460479439 1 13.2007845967948 2300 191 273 143 1391 3655 3475 1777 1004 657 3783 1130 M15357 GO_GOLGI_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_VESICLE_TRANSPORT.html The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. 209/431 Gene Ontology BP GO:0048193 0.00756439458534983 0.033449032437885 2295 1544.09090909091 1392 0.000690048145375388 121 1.19344331958811 1.39524028548027 1 6.68470912082318 2295 481 2974 1392 324 121 2295 3402 1023 1748 930 1131 M10531 GO_CIRCULATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. 197/596 Gene Ontology BP GO:0003013 4.31307910717455e-09 3.49341679817767e-07 350 1152 1393 3.92098101420936e-10 57 1.48902520167428 1.41979901115027 1 36.494147524891 349 597 57 1436 1639 1709 1393 2203 1014 539 1736 1132 M10857 GO_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ACTIVATION.html A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. 90/224 Gene Ontology BP GO:0030168 5.59107770776501e-05 0.000910855220952734 385 1124.45454545455 1394 5.08292709491944e-06 232 1.450099563759 1.56367030919606 1 16.7362168766536 381 1722 232 1799 1394 1477 1534 541 1516 461 1312 1133 M12333 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 79/210 Gene Ontology BP GO:0090288 0.00999494250964502 0.0405651381750715 1860 1604.09090909091 1394 0.000912785638459797 344 1.26846303942301 1.33744201585055 1 6.70157000465257 1860 1268 1394 446 383 4597 2520 782 1436 344 2615 1134 M14919 GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. 9/23 Gene Ontology BP GO:0051497 0.0747891079882797 0.158445571591463 605 1810.27272727273 1395 0.0077432231973239 442 1.19045135446987 1.19045135446987 1 3.6155465174851 601 1405 4318 1201 3632 907 442 1395 3595 1617 800 1135 M10719 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. 7/15 Gene Ontology BP GO:0002583 0.0572230903266938 0.135368812869288 1035 1625.36363636364 1397 0.00587523286345961 611 1.70932184675759 1.70932184675759 1 5.6349697110893 1034 1816 3625 1928 2474 1606 611 748 1284 1397 1356 1136 M12087 GO_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION.html The attachment of one cell to another cell via adhesion molecules. 290/888 Gene Ontology BP GO:0098609 5.5551400758983e-11 8.32016624915994e-09 955 1241.72727272727 1399 5.05012734185324e-12 31 1.55872553058536 1.66122213003501 1 47.8058611207889 952 1624 31 523 2398 2318 1399 1407 856 157 1994 1137 M11477 GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 7/20 Gene Ontology BP GO:0010763 0.000485777362376999 0.0047785260455856 4175 1746.18181818182 1400 4.85883585899686e-05 26 2.19775722972283 2.19775722972283 1 19.3600770544318 4171 306 3754 334 63 1834 2639 425 26 1400 4256 1138 M11657 GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 49/129 Gene Ontology BP GO:0045428 0.107922987360964 0.194152707462157 1825 1704 1401 0.0103283662143071 574 1.2313228060909 1.29171715701373 1 3.3271443178502 1822 1013 927 574 1534 4107 2876 1040 1401 942 2508 1139 M13259 GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. 78/178 Gene Ontology BP GO:0032845 0.0374864088166347 0.100028388583698 815 1883.27272727273 1402 0.00346734684040508 413 1.54755113445415 1.54755113445415 1 5.8735233435242 1402 4440 739 4249 3491 1531 815 815 1165 1656 413 1140 M10476 GO_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of a cytokine. 305/853 Gene Ontology BP GO:0001817 0.000554460401864451 0.00529703630834701 910 1528.45454545455 1403 5.04181991303561e-05 340 1.23088878626076 1.29491074936506 1 10.6338864022032 908 1261 340 1403 2129 2510 1198 1457 2117 1282 2208 1141 M12157 GO_STARTLE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STARTLE_RESPONSE.html An action or movement due to the application of a sudden unexpected stimulus. 6/45 Gene Ontology BP GO:0001964 0.0405380107748314 0.105799878598956 2860 2004.90909090909 1406 0.00412970716066881 277 1.51935086267539 -1.51935086267539 -1 5.62599295699267 2859 444 3859 277 923 1406 3222 3589 3309 1315 851 1142 M15832 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of endothelial cell proliferation. 44/103 Gene Ontology BP GO:0001938 0.0839184282471183 0.158445571591463 1410 1543.09090909091 1407 0.00793650793650794 892 1.66409842843252 1.66409842843252 1 5.05407067257677 1407 1367 892 1341 1952 1145 1421 2528 1160 2172 1589 1143 M10796 GO_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. 646/1734 Gene Ontology BP GO:0051336 0.00958628101128152 0.0392592104060817 195 1657.81818181818 1408 0.000962788739230799 193 1.44409136288312 1.51193760570293 1 7.70735340218459 1428 327 3638 193 854 4498 2009 1408 1049 193 2639 1144 M12790 GO_PROSTAGLANDIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. 13/44 Gene Ontology BP GO:0006693 0.161385165508919 0.258740097879113 1385 1636.18181818182 1408 0.0158730158730159 1080 1.29064118907003 1.29064118907003 1 2.87641573258173 1382 1394 1626 1563 2478 1408 1080 2710 1295 1940 1122 1145 M11995 GO_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 60/201 Gene Ontology BP GO:0001816 0.0200313633092405 0.0659614325140451 1410 1398.63636363636 1409 0.00183782832209854 586 1.98867217541532 1.98867217541532 1 8.91278932178012 1409 2341 1045 1688 586 1530 1541 994 1059 1901 1291 1146 M15959 GO_PROSTANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. 13/44 Gene Ontology BP GO:0006692 0.161385165508919 0.258740097879113 1385 1633.54545454545 1409 0.0158730158730159 1081 1.29064118907003 1.29064118907003 1 2.87641573258173 1383 1395 1627 1564 2479 1409 1081 2649 1296 1963 1123 1147 M14129 GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. 158/476 Gene Ontology BP GO:0072507 3.03547679314924e-06 8.59373094548289e-05 895 1343.45454545455 1410 2.7595281649031e-07 154 1.31481400234621 1.54354143015628 1 20.2917504301569 893 1763 154 1705 745 2132 1410 1796 1141 1288 1751 1148 M12739 GO_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of neuron differentiation. 298/801 Gene Ontology BP GO:0045664 0.000340404530464479 0.00365011139710526 850 1379 1411 3.09506556765888e-05 313 1.55345690497081 1.59357880989767 1 14.3742637088401 846 1304 313 1081 1848 3079 1610 1411 1547 648 1482 1149 M15772 GO_NEPHRON_TUBULE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_TUBULE_FORMATION.html The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. 9/25 Gene Ontology BP GO:0072079 0.0904932796647475 0.168051790029106 1465 1648 1412 0.00944044574153848 760 1.80540289925521 1.80540289925521 1 5.30804590108594 1461 831 4455 959 1308 1412 760 2091 1264 1626 1961 1150 M10523 GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. 8/19 Gene Ontology BP GO:0048715 0.00708559207122692 0.031724594008396 1450 1631.81818181818 1413 0.000710828650659647 330 0.849254971022537 0.849254971022537 1 4.83094613373479 1447 1129 3598 1379 330 1361 1413 1024 1701 3041 1527 1151 M16294 GO_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXONOGENESIS.html Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. 97/250 Gene Ontology BP GO:0050770 0.0110668472836166 0.0438050911660971 770 1305.45454545455 1415 0.00101117391203892 492 1.44861649874699 1.53080097217031 1 7.46985962133268 769 492 580 664 1564 2920 1736 2204 1415 535 1481 1152 M15961 GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS.html The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 11/32 Gene Ontology BP GO:0021692 0.00470006677113048 0.0241131602412805 1090 1798.81818181818 1416 0.000428194372843813 211 1.17287447352151 -1.03069309216194 -1 7.20226446731637 1087 3021 1164 3318 3153 1042 2045 211 2550 780 1416 1153 M14737 GO_RESPONSE_TO_PARATHYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PARATHYROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. 11/27 Gene Ontology BP GO:0071107 0.0839184282471183 0.158445571591463 910 1440 1417 0.00793650793650794 206 1.9083122944764 1.9083122944764 1 5.79577808432812 909 2357 1417 834 1248 894 1777 2664 206 1808 1726 1154 M13999 GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION.html The modification of peptidyl-glutamic acid. 12/35 Gene Ontology BP GO:0018200 0.00441508069119778 0.023032831066552 2525 1510.90909090909 1418 0.000402178735615911 71 2.03378537143284 -1.54796415353554 -1 12.6425345729353 2521 1117 1642 1418 239 1653 1345 3260 71 823 2531 1155 M14374 GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY.html Any process that activates or increases the activity of a cyclase. 22/72 Gene Ontology BP GO:0031281 0.208960076288391 0.317890443711336 1110 2159.90909090909 1418 0.0210842650501803 1001 1.14796226859257 -1.29245240179828 -1 2.16881317449821 2933 1109 1109 1001 3115 1324 4425 3686 2370 1269 1418 1156 M14497 GO_LIPID_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 42/112 Gene Ontology BP GO:0046834 0.000377294133143565 0.00392634179109736 1605 1478.90909090909 1418 3.43053503291752e-05 56 1.66927978942771 1.84083109373717 1 15.2452354778918 1602 782 1418 823 56 2201 1993 2685 555 1277 2876 1157 M14817 GO_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 141/332 Gene Ontology BP GO:0051260 0.0650802618356359 0.147211315059836 960 1529.27272727273 1418 0.00609901548044078 488 1.4316249374949 1.65813060280269 1 4.52158300652008 957 488 1652 1620 2348 2558 1418 762 1155 2644 1220 1158 M10996 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. 20/51 Gene Ontology BP GO:1900077 0.0206731595126456 0.0674132749412629 1030 1534.45454545455 1419 0.00189727433180763 320 1.23719315255334 1.23719315255334 1 5.50042235844982 1026 2495 1017 2691 1964 967 1419 453 2246 2281 320 1159 M11393 GO_NEURAL_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. 102/237 Gene Ontology BP GO:0021915 0.0839184282471183 0.158445571591463 1290 1731 1421 0.00793650793650794 719 1.41473468668751 1.38968534156413 1 4.29672245779075 1286 1421 1998 1107 1953 3834 3143 1104 719 832 1644 1160 M12916 GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. 95/216 Gene Ontology BP GO:0071559 0.000522086703143972 0.00507123130271435 1245 1325.18181818182 1422 4.74736947122346e-05 150 1.35319039311554 1.34659594873948 1 11.7876535581029 1244 1422 334 630 461 2926 1913 1523 1445 150 2529 1161 M14860 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. 24/61 Gene Ontology BP GO:0030857 0.249814979718619 0.363260554598668 2315 1685.36363636364 1422 0.0257920447796683 643 1.43906464096618 -1.07272638267715 -1 2.40228619031857 2311 798 1422 643 3065 874 3474 1695 1975 1357 925 1162 M15091 GO_PROTEIN_LOCALIZATION_TO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_SYNAPSE.html Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 7/20 Gene Ontology BP GO:0035418 0.00966994751077879 0.039522505539213 870 1764.36363636364 1423 0.00097122855810303 182 1.51935086267539 -1.51935086267539 -1 8.0922840813413 868 3512 4349 1753 4109 518 367 1742 585 1423 182 1163 M14008 GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. 65/154 Gene Ontology BP GO:2000117 0.00345675801313049 0.0193360055278893 1390 1455.63636363636 1425 0.000314745584973949 198 1.48729950668054 1.66089832256413 1 9.67438891639871 1390 1426 1505 1004 198 3090 2229 1425 870 2045 830 1164 M11975 GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. 203/495 Gene Ontology BP GO:0043623 0.00843233783089782 0.0362020544295597 955 1988.27272727273 1426 0.000769530225323743 80 0.860094540452276 -0.679072464854214 -1 4.70541355819875 954 4004 3370 4135 1426 80 588 1131 2982 2837 364 1165 M16382 GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. 18/171 Gene Ontology BP GO:0050853 0.0384768534590144 0.101968054001258 1430 1911.81818181818 1426 0.00356061328161954 404 2.24458518468169 2.24458518468169 1 8.44795812672404 1426 3811 1425 3296 3703 1026 404 610 2511 2214 604 1166 M11279 GO_MONOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 34/87 Gene Ontology BP GO:0046365 0.161385165508919 0.258740097879113 1620 1709.27272727273 1427 0.0158730158730159 787 1.21271287378463 1.21271287378463 1 2.70273908719602 1619 787 1576 897 1782 4393 1207 1148 1427 2604 1362 1167 M15854 GO_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_MEDIATED_ENDOCYTOSIS.html An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. 103/399 Gene Ontology BP GO:0006898 0.00135820502081946 0.00969112621539502 845 1426.18181818182 1428 0.000123549477796402 26 1.24710382245852 1.34660233358274 1 9.5321001743584 845 26 399 585 1462 3037 1087 2276 1428 2232 2311 1168 M16261 GO_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. 70/170 Gene Ontology BP GO:0030217 0.161385165508919 0.258740097879113 1070 1674.36363636364 1429 0.0158730158730159 662 1.44167626121451 1.53437449177956 1 3.21302335164259 1066 2956 1339 2184 2382 1375 1145 2361 1519 662 1429 1169 M16792 GO_LUNG_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_ALVEOLUS_DEVELOPMENT.html The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. 29/56 Gene Ontology BP GO:0048286 0.00721567586857241 0.0322448345118207 1665 1501 1429 0.000658131951531724 541 1.05402127388661 1.05985331931777 1 5.96748681328366 1664 715 541 1696 3055 1190 1429 2120 1778 901 1422 1170 M14604 GO_FUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. 5/15 Gene Ontology BP GO:0006004 0.0208530545145692 0.0677541862219349 1325 1886.27272727273 1432 0.00210513610451674 526 0.715858725339802 0.715858725339802 1 3.17667504516477 1324 2693 4255 1868 625 869 1432 632 2475 4050 526 1171 M11054 GO_BARBED_END_ACTIN_FILAMENT_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BARBED_END_ACTIN_FILAMENT_CAPPING.html The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. 9/19 Gene Ontology BP GO:0051016 0.0765897756730953 0.158445571591463 1865 1903.18181818182 1433 0.00793650793650794 322 0.916001837656024 -0.97975757930076 -1 2.78200973241234 1861 829 3677 654 4468 1433 1767 1362 322 3151 1411 1172 M16477 GO_INNERVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNERVATION.html The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. 7/39 Gene Ontology BP GO:0060384 0.0357921027261406 0.0967569299056863 1000 1984.45454545455 1433 0.00363820030804517 449 1.72827849287814 1.72827849287814 1 6.65418781855034 998 3445 4570 2847 2726 1035 449 619 3007 1433 700 1173 M16706 GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. 116/236 Gene Ontology BP GO:2001235 0.0839184282471183 0.158445571591463 1670 1836 1435 0.00793650793650794 929 1.4629926060158 1.65941954884327 1 4.44328766729877 1670 929 2562 1369 1398 4502 2108 1838 1038 1435 1347 1174 M11959 GO_HEXOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 27/78 Gene Ontology BP GO:0019320 0.15054823885663 0.252618530181182 1440 1652 1436 0.0147236336858253 719 1.21271287378463 1.21271287378463 1 2.75060621201244 1436 1024 1550 943 2332 3955 928 1056 1737 2492 719 1175 M11043 GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of glia cell differentiation. 16/45 Gene Ontology BP GO:0045687 0.00349648182536835 0.0194767500939333 615 1665.18181818182 1437 0.000318368292240619 183 0.751564534681695 0.751564534681695 1 4.87969188409418 612 2458 1437 2281 3797 592 522 183 2847 3148 440 1176 M16593 GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. 417/956 Gene Ontology BP GO:0034622 0.0614260584751163 0.141709283336511 460 2117.27272727273 1438 0.00574648353950134 271 0.985303216317216 -0.848902265540361 -1 3.1738107594303 459 4431 3464 4297 1235 271 1438 1296 2799 2888 712 1177 M10503 GO_MYELOID_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MIGRATION.html The movement of a myeloid leukocyte within or between different tissues and organs of the body. 47/150 Gene Ontology BP GO:0097529 0.000225881613518189 0.00266862170881668 1560 1391.27272727273 1439 2.05368008090358e-05 289 1.36139201997492 1.36139201997492 1 13.2999664487915 898 1319 289 1557 2365 2219 1337 1760 561 1439 1560 1178 M11589 GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 455/1065 Gene Ontology BP GO:0044087 0.0839184282471183 0.158445571591463 1470 1757.18181818182 1439 0.00793650793650794 751 1.22206273448414 1.31132961694643 1 3.7115541489603 1469 1756 1439 751 1352 4592 2112 1217 1163 1248 2230 1179 M12444 GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 325/835 Gene Ontology BP GO:0031344 0.00505308479230417 0.0252817593649443 1295 1562.09090909091 1439 0.000460429860246398 500 1.37774611617096 1.4989810966833 1 8.35283196795645 1292 1623 500 986 1472 4102 2015 1439 1016 522 2216 1180 M13006 GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS.html The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 78/326 Gene Ontology BP GO:0050953 0.0780297068754778 0.158445571591463 980 1586.27272727273 1439 0.00735845447716831 787 1.28494461703039 1.28494461703039 1 3.90253412526129 980 1471 1057 2430 1537 3747 1177 818 2006 787 1439 1181 M12626 GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that reduces the force with which blood travels through the systemic arterial circulatory system. 6/15 Gene Ontology BP GO:0003085 0.0662439188733307 0.148944559481295 1895 1981.81818181818 1442 0.00683056789054135 883 1.14082867248978 1.14082867248978 1 3.58113115101611 1892 1253 3940 1442 1149 2749 883 4229 1664 1318 1281 1182 M12397 GO_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 22/76 Gene Ontology BP GO:0090183 0.0200901509350725 0.0661081295475136 3705 2021.36363636364 1445 0.00184327201991414 95 1.88722707103291 2.13625646782842 1 8.4512234015971 3703 95 657 198 1445 3509 4471 4352 151 696 2958 1183 M16159 GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. 29/67 Gene Ontology BP GO:0035306 0.00539772031628799 0.0263806478195001 1445 1671.90909090909 1446 0.000491909940185402 268 1.8552912284493 1.8552912284493 1 11.1179043218487 1444 2489 1005 1446 268 3500 2210 1968 576 900 2585 1184 M15320 GO_RESPONSE_TO_MINERALOCORTICOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MINERALOCORTICOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. 20/50 Gene Ontology BP GO:0051385 0.0416565956219855 0.108036334310191 905 1730.09090909091 1447 0.00386062904106006 331 1.06637231236526 1.06637231236526 1 3.91188938762645 905 2780 2308 2647 2601 1447 331 755 2843 1153 1261 1185 M16494 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 12/42 Gene Ontology BP GO:0003071 0.0533390763337973 0.128412546887568 1450 1533.90909090909 1448 0.00497072332285426 996 1.45023161899474 1.45023161899474 1 4.90697218371417 1078 1976 1334 1565 996 1093 2158 1884 1448 1893 1448 1186 M13260 GO_APPENDAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APPENDAGE_DEVELOPMENT.html The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. 94/288 Gene Ontology BP GO:0048736 0.000116256648195296 0.0016209598125248 920 1461.54545454545 1449 1.05693447371029e-05 222 1.42843566267723 1.53142815920548 1 15.1289075648974 916 1882 261 1449 870 3228 2504 839 1468 222 2438 1187 M10227 GO_POSITIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA replication. 39/115 Gene Ontology BP GO:0045740 0.0839184282471183 0.158445571591463 1235 1477.54545454545 1450 0.00793650793650794 687 1.45895769169445 1.45895769169445 1 4.43103313848595 1232 2204 1450 2189 2085 2177 687 1238 766 735 1490 1188 M14599 GO_LIMB_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMB_DEVELOPMENT.html The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. 94/288 Gene Ontology BP GO:0060173 0.000116256648195296 0.0016209598125248 920 1459.36363636364 1450 1.05693447371029e-05 223 1.42843566267723 1.53142815920548 1 15.1289075648974 917 1883 262 1450 871 3229 2505 805 1469 223 2439 1189 M11183 GO_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE.html Any process that modulates the frequency, rate or extent of a defense response. 435/1123 Gene Ontology BP GO:0031347 0.0917142139921965 0.169856041310637 1340 1835.54545454545 1451 0.00870698253276811 893 1.21535238425011 1.27571079496706 1 3.551848937509 1337 1413 893 1780 1315 4090 1451 1434 1621 2403 2454 1190 M15321 GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. 36/68 Gene Ontology BP GO:2001244 0.00698769880739622 0.0314074400413753 1455 1417.90909090909 1451 0.000637272047289304 133 1.86456658958525 1.86456658958525 1 10.6373808181754 1052 1580 2711 1452 1199 1667 1070 1366 1451 1916 133 1191 M11454 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 63/113 Gene Ontology BP GO:0008630 0.0533508083019857 0.128412546887568 465 1463.81818181818 1452 0.00497184436527429 436 1.5364362334748 1.5364362334748 1 5.19865224353107 464 2703 2226 2681 1452 837 555 1172 1595 1981 436 1192 M15295 GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION.html The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. 26/73 Gene Ontology BP GO:0006929 0.00373228554820709 0.0204110739697592 520 1519.90909090909 1455 0.000339875675059758 91 1.61112816865721 1.61112816865721 1 10.336142715737 519 3948 1568 3398 1784 260 91 588 2664 1455 444 1193 M10787 GO_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_PROLIFERATION.html The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. 6/25 Gene Ontology BP GO:0043616 0.0151978924444518 0.0546159555879176 900 1599.81818181818 1458 0.00153028432198415 495 0.648105411662898 0.800090281236101 1 3.10632105091189 897 1195 3634 1533 533 685 495 1577 2498 3093 1458 1194 M13461 GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of dendrite development. 48/107 Gene Ontology BP GO:1900006 0.119594076778258 0.211051044652775 645 1622.90909090909 1460 0.0115125090640033 643 1.57914678242171 1.57914678242171 1 4.04974243703364 643 2881 1794 2390 1406 2052 846 1363 1777 1460 1240 1195 M10417 GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 22/54 Gene Ontology BP GO:0000271 0.00620435464267814 0.0291563494768833 1360 1425.36363636364 1461 0.000565629210852024 201 1.73035500290193 1.73035500290193 1 10.0838486207942 1356 1538 2508 610 281 2620 2033 1814 201 1257 1461 1196 M11855 GO_REGULATION_OF_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENERGY_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of energy homeostasis. 12/44 Gene Ontology BP GO:2000505 8.63150392306837e-05 0.00128448951008995 450 1567.36363636364 1461 7.847129628213e-06 9 0.502196815074364 0.506788476533989 1 5.51149922552266 449 2393 1461 2613 2840 99 9 75 3725 3355 222 1197 M13520 GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of lymphocyte differentiation. 68/229 Gene Ontology BP GO:0045619 0.0361660603079348 0.0973046684529161 2440 1966.18181818182 1461 0.00334315018163899 643 1.46512620674738 1.46512620674738 1 5.62736920409084 2436 1270 851 1461 813 4539 2754 2375 956 643 3530 1198 M13057 GO_OVULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION.html The release of a mature ovum/oocyte from an ovary. 8/28 Gene Ontology BP GO:0030728 0.0440106435835518 0.112152260240632 1075 2304.27272727273 1462 0.00449073629874203 724 0.390891840623092 0.491895227970132 1 1.40985741206147 1073 3511 4002 3504 954 724 1025 1462 4227 3639 1226 1199 M15568 GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 48/182 Gene Ontology BP GO:0033559 0.0839184282471183 0.158445571591463 1520 1393.90909090909 1463 0.00793650793650794 491 1.19308812762026 1.52862599404657 1 3.62355472037888 1517 1014 880 584 1526 2582 1239 1478 491 1463 2559 1200 M10751 GO_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. 270/646 Gene Ontology BP GO:0030029 0.0013820050928614 0.00976659002458978 1465 1670.81818181818 1465 0.000125715819164123 400 1.27748272145836 1.30735771878468 1 9.74796268653538 1464 595 401 400 2032 3985 2274 2158 878 1465 2727 1201 M10365 GO_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_TISSUE_DEVELOPMENT.html The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. 155/442 Gene Ontology BP GO:0060537 1.53963366094735e-07 7.36960730698818e-06 1240 1582.09090909091 1467 1.39966706245098e-08 97 1.56854389346447 1.51377454086521 1 30.558889958113 1238 1467 97 910 1749 3895 2081 2524 773 131 2538 1202 M12786 GO_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FISSION.html The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 7/15 Gene Ontology BP GO:0000266 0.065055621603623 0.147211315059836 940 1840.18181818182 1468 0.00670424954691571 538 0.368987349082435 -0.405820342751086 -1 1.16539387052271 937 2140 3959 2583 1139 538 963 1468 1835 3575 1105 1203 M16269 GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 428/1010 Gene Ontology BP GO:0051129 0.018348322916297 0.0623940599297304 4020 1944.90909090909 1468 0.0016821055996393 448 1.20287151792155 1.31874734274462 1 5.50125643102593 4016 2041 641 1132 1456 448 3874 2923 1217 1468 2178 1204 M10390 GO_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 22/68 Gene Ontology BP GO:0010043 0.0259431006208071 0.0786765618435056 1470 1550.63636363636 1470 0.0023867434415072 572 1.77514984074604 -1.03069309216194 -1 7.43998646706353 1470 1537 696 1271 3956 1666 1842 908 572 1256 1883 1205 M13527 GO_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. 32/126 Gene Ontology BP GO:0021675 0.161385165508919 0.258740097879113 600 1389.09090909091 1470 0.0158730158730159 575 1.44276900116139 1.44276900116139 1 3.21545871044069 598 2488 1155 2110 1634 1470 966 1995 1482 575 807 1206 M15198 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin polymerization. 47/97 Gene Ontology BP GO:0030838 0.0229476617261293 0.0723326499622665 1740 1561.18181818182 1470 0.00210823436201504 482 0.885892611905994 -0.625059557561618 -1 3.83571794490085 1740 616 1470 1134 2007 2717 940 482 1111 2729 2227 1207 M11101 GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 4/21 Gene Ontology BP GO:0042136 0.335167364008499 0.455556812380404 1475 1996.36363636364 1471 0.04 583 0.809972299578793 -0.777954883281668 -1 1.04981795469633 1471 583 3690 1074 3138 1326 1045 2506 2493 3167 1467 1208 M14292 GO_NEUTRAL_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. 40/116 Gene Ontology BP GO:0006638 0.00389172772304482 0.0210843545135322 545 1443.36363636364 1471 0.000354420832670045 471 1.00551252248442 -1.27675999939789 -1 6.39703922291963 544 2011 471 1732 1471 958 848 1027 2626 2669 1520 1209 M10616 GO_RESPONSE_TO_PROSTAGLANDIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 19/86 Gene Ontology BP GO:0034695 0.0532662548848665 0.128342097265405 1075 1540.45454545455 1473 0.00496376518779499 546 1.08918898596586 1.08918898596586 1 3.68634151601184 1071 546 790 1473 1353 2305 1759 1328 2410 2234 1676 1210 M15232 GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. 590/1532 Gene Ontology BP GO:0051248 0.0109801116023735 0.0435360018529634 1825 1774.18181818182 1474 0.00110347451957299 442 1.25406386084359 1.32489179273479 1 6.47937828632607 1821 1620 4373 1248 442 2494 2525 1263 1172 1084 1474 1211 M15345 GO_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. 19/91 Gene Ontology BP GO:0048663 0.057747170777002 0.135971781708251 345 1671.36363636364 1474 0.00539282841069508 345 0.849254971022537 0.849254971022537 1 2.79344138227003 345 1031 1976 2191 1474 774 386 1923 3527 4247 511 1212 M11228 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. 52/151 Gene Ontology BP GO:0051153 0.161385165508919 0.258740097879113 1420 1688.18181818182 1475 0.0158730158730159 869 1.54444415987415 1.54444415987415 1 3.44205927814989 1419 869 1105 1475 2967 3613 1302 1534 1499 1021 1766 1213 M15905 GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. 27/77 Gene Ontology BP GO:1902930 0.0335448269661061 0.0932003951166524 2125 1751.63636363636 1478 0.00309704533277138 81 1.2065059794984 -1.3614662588433 -1 4.71975403502988 2124 81 729 945 3624 1649 1259 3378 1424 1478 2577 1214 M11817 GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 9/33 Gene Ontology BP GO:0061217 0.00918625388177371 0.0381500686700137 1800 1746.27272727273 1479 0.000922445056378519 147 0.437202227497503 -0.424346326736112 -1 2.35407539874372 1799 147 3811 1479 3525 408 311 316 3396 3347 670 1215 M12805 GO_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. 50/169 Gene Ontology BP GO:0030216 0.0013276591935816 0.00961672642090389 1480 1473.18181818182 1479 0.000120769189896486 394 1.58666131796926 1.58666131796926 1 12.1476282647406 1479 870 394 920 3183 2104 1492 2460 1518 628 1157 1216 M15744 GO_NEUROMUSCULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS.html Any process pertaining to the functions of the nervous and muscular systems of an organism. 41/199 Gene Ontology BP GO:0050905 0.00109945016496701 0.00830040181453953 2120 1788.18181818182 1479 1e-04 62 1.81611917212185 1.89031124948347 1 14.3450798081976 2117 944 418 62 4464 3585 2638 832 1479 465 2666 1217 M15770 GO_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_KILLING.html Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 31/141 Gene Ontology BP GO:0001906 0.017211803257349 0.059816169553796 2590 1559.54545454545 1479 0.00157708674723538 223 0.955856589839509 0.955856589839509 1 4.43803618208238 773 1479 2590 1242 2427 997 271 2589 2000 2564 223 1218 M15948 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of lamellipodium organization. 21/46 Gene Ontology BP GO:1902745 0.0146568608915238 0.0532903720590015 1050 1603.36363636364 1479 0.00134140259578697 208 1.72166503424634 1.72166503424634 1 8.32154773126824 1049 2670 1536 700 4520 2468 1955 383 208 669 1479 1219 M16683 GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 9/30 Gene Ontology BP GO:0061213 0.0104276243034221 0.0417015156251411 1800 1931.63636363636 1480 0.00104768808209829 148 0.437202227497503 -0.424346326736112 -1 2.28992308843279 1800 148 4604 1480 3526 409 312 338 3397 4563 671 1220 M10799 GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. 32/65 Gene Ontology BP GO:1901185 0.0775872993646016 0.158445571591463 1100 1731.63636363636 1481 0.00731516218113372 742 1.49638166042083 1.77354055842398 1 4.54469431355012 1100 4220 1782 2949 1186 1972 749 1481 742 974 1893 1221 M10875 GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. 19/37 Gene Ontology BP GO:0032793 0.120959614546692 0.213298705028595 1485 1405.36363636364 1482 0.0116519870384493 535 1.61156951470423 1.61156951470423 1 4.10474724288686 911 2212 1727 1482 1482 1486 535 1655 1732 1117 1120 1222 M11618 GO_CRANIAL_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 25/92 Gene Ontology BP GO:0021545 0.0839184282471183 0.158445571591463 1030 1570.36363636364 1482 0.00793650793650794 790 1.34759917058913 1.34759917058913 1 4.09282367559395 1029 1482 1253 1588 1682 2391 1548 3500 918 790 1093 1223 M11029 GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 49/108 Gene Ontology BP GO:0071322 0.119117559637634 0.210604206139208 1405 1613.72727272727 1483 0.0114638832099887 647 1.32369122767442 1.49279125979972 1 3.39924823915979 647 2412 1870 2059 1401 1746 1101 1404 2820 1483 808 1224 M14513 GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organonitrogen compound. 923/2218 Gene Ontology BP GO:1901564 0.0251331326963122 0.0769743635283492 3220 2032.72727272727 1483 0.00254219949013424 396 1.38757935882274 1.57097252113094 1 5.86563860459132 3216 1062 4246 1483 704 396 3582 4284 1078 706 1603 1225 M12992 GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrate derivative. 296/665 Gene Ontology BP GO:1901137 0.0167642234301028 0.0585675616147233 4460 2034.27272727273 1484 0.00153575892311326 535 1.31317169969783 1.4589344104227 1 6.14271403420604 4460 856 1796 1484 535 1055 4641 2470 1107 968 3005 1226 M13439 GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. 49/123 Gene Ontology BP GO:0006767 0.000985330757384821 0.00802843402704691 3690 1860 1484 8.96156674443041e-05 54 1.14531564199034 1.22892827013657 1 9.10946706780576 3687 54 573 650 92 1620 4472 2984 734 1484 4110 1227 M16581 GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 76/177 Gene Ontology BP GO:0034614 0.00401696118267771 0.0215366637080515 1780 1346.36363636364 1484 0.000365846774689058 222 1.46579454986648 1.55281484140739 1 9.27405028664764 1776 771 689 505 222 2794 1600 1484 1529 1060 2380 1228 M14255 GO_CELLULAR_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCOSE_HOMEOSTASIS.html A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. 49/105 Gene Ontology BP GO:0001678 0.0926299778908753 0.17141529985944 1520 1468.54545454545 1485 0.00879788370354203 556 1.32369122767442 1.49279125979972 1 3.84852736418802 556 1520 1516 1881 1278 1758 1323 1193 2656 1485 988 1229 M16299 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE.html The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. 14/57 Gene Ontology BP GO:0001990 0.161385165508919 0.258740097879113 1180 1867.72727272727 1485 0.0158730158730159 788 0.528032436766238 0.549039078357438 1 1.17681104644378 1178 892 1723 1530 4631 1012 1562 1279 1485 4465 788 1230 M15149 GO_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 13/35 Gene Ontology BP GO:0046058 0.0485530334315115 0.119828721561994 1145 1883.72727272727 1486 0.00451444552347436 351 0.502794892350047 0.555912053430932 1 1.75859046081016 1143 818 1372 1947 2757 999 351 1936 3720 4192 1486 1231 M11628 GO_MEMBRANE_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. 8/24 Gene Ontology BP GO:0046466 0.0765897756730953 0.158445571591463 1235 1986.45454545455 1488 0.00793650793650794 114 2.06322935667965 2.06322935667965 1 6.26628016966936 1234 3723 3777 1315 4618 1865 1342 872 114 1503 1488 1232 M10049 GO_REGULATION_OF_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING_BY_RNA.html Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. 8/27 Gene Ontology BP GO:0060966 0.0153025483123481 0.0548223239307347 2550 1688.54545454545 1489 0.00154089566322562 144 1.35593454827845 1.35593454827845 1 6.49046333885489 2549 144 3524 633 538 981 801 2655 2610 1489 2650 1233 M11178 GO_REGULATION_OF_HORMONE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_LEVELS.html Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. 229/704 Gene Ontology BP GO:0010817 0.000530515501459255 0.00511033915617286 915 1347.27272727273 1489 4.82403159074771e-05 338 1.19869505678563 -0.929024488444665 -1 10.4266629648596 914 1674 338 1523 1489 1572 1467 1324 1604 1273 1642 1234 M13193 GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. 16/30 Gene Ontology BP GO:0036119 0.0839184282471183 0.158445571591463 1010 1670.63636363636 1489 0.00793650793650794 438 2.10912650998802 2.10912650998802 1 6.40567544373209 1671 3540 1010 1360 1516 2587 1469 1489 438 1007 2290 1235 M13235 GO_GLYOXYLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYOXYLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. 18/32 Gene Ontology BP GO:0046487 0.0104137045691535 0.0417015156251411 1490 1595.54545454545 1490 0.000951211547049464 115 0.694957063565193 -0.694957063565193 -1 3.63995909737693 1490 1170 2442 2000 1163 115 155 1832 3084 3680 420 1236 M14536 GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/28 Gene Ontology BP GO:0010829 0.0187490461190392 0.0633564928171027 1955 1574.63636363636 1491 0.00171916034599962 558 1.82051220676583 1.82051220676583 1 8.28005758543039 2000 558 644 568 708 3455 3088 901 1954 1954 1491 1237 M16211 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. 41/115 Gene Ontology BP GO:0032755 0.000963755430858688 0.00791985215128653 1665 1401.54545454545 1492 8.76525348126558e-05 91 1.2173709861558 1.38114177468899 1 9.70989893520016 1663 385 1492 449 2786 1992 941 91 1447 2096 2075 1238 M10341 GO_PINOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PINOCYTOSIS.html An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. 9/23 Gene Ontology BP GO:0006907 0.0405282401469713 0.105799878598956 620 1622.45454545455 1493 0.00412869302633641 340 1.69748649654937 1.69748649654937 1 6.28561006467723 618 2941 3568 2147 1493 572 340 822 2926 1580 840 1239 M11408 GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. 10/19 Gene Ontology BP GO:0035886 0.0839184282471183 0.158445571591463 780 1512.36363636364 1493 0.00793650793650794 152 1.70820157422404 1.70820157422404 1 5.18801732615965 779 1741 1855 1336 3267 1094 520 2719 152 1680 1493 1240 M15904 GO_PATTERN_SPECIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_SPECIFICATION_PROCESS.html Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. 210/609 Gene Ontology BP GO:0007389 0.000176324314265468 0.00222465704112654 1595 1716.54545454545 1494 1.60307679808597e-05 280 1.32588388242157 1.39152214578822 1 13.3507881959117 1593 1566 280 1494 1056 4436 2955 1249 997 484 2772 1241 M16383 GO_RECEPTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 12/24 Gene Ontology BP GO:0032801 0.00400065764385956 0.0214740502201618 910 1821 1495 0.000364359212577181 123 0.410646909983597 -0.415094521572995 -1 2.60012505938772 906 1495 2452 2588 4157 123 505 198 2964 4486 157 1242 M16616 GO_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_BACTERIUM.html Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. 113/539 Gene Ontology BP GO:0042742 1.61529947595801e-06 5.03344662206246e-05 2175 1464.81818181818 1496 1.46845514723253e-07 143 1.6572487390417 -1.22460557857138 -1 27.038023003716 2173 491 143 1154 873 882 2782 2315 1496 1919 1885 1243 M15229 GO_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. 472/1348 Gene Ontology BP GO:0030030 0.000849233240381209 0.00722159328771054 2795 1714.45454545455 1498 7.72328395010857e-05 110 1.32890408852356 1.55511720195836 1 10.8016964619127 2795 681 364 244 1498 2175 3847 1941 837 110 4367 1244 M11502 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 25/54 Gene Ontology BP GO:0090313 0.00423387588187672 0.022305944159712 2700 1683.36363636364 1499 0.000385640540961688 233 1.24907563888908 1.36658472553921 1 7.83060691999977 2697 951 2633 1499 233 777 2703 3271 1693 789 1271 1245 M12125 GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. 5/10 Gene Ontology BP GO:0031284 0.0184962116420683 0.0627762504781602 4305 2279.18181818182 1499 0.00186519890146149 417 1.57084733800775 -1.57084733800775 -1 7.16835668287256 4304 1256 3853 417 590 4515 1499 3682 1413 1195 2347 1246 M12239 GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. 8/18 Gene Ontology BP GO:0042982 0.0333754639440844 0.0930291037311123 980 2032.27272727273 1499 0.00338875875377199 299 0.288150071864069 -0.288150071864069 -1 1.12809366024616 976 2827 3873 2972 1407 309 299 1499 4112 3444 637 1247 M16135 GO_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOCLAST_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. 29/50 Gene Ontology BP GO:0030316 0.0986938385411343 0.180467567090794 950 1487.63636363636 1500 0.00940191186914398 578 1.14188823668349 1.31054955612798 1 3.22307713851887 947 1964 2201 1021 2882 1500 1115 1522 1735 899 578 1248 M11540 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. 8/23 Gene Ontology BP GO:2000696 0.00402890208808099 0.0215757697750404 4070 2172.54545454545 1501 0.000403622520435428 217 1.80540289925521 1.80540289925521 1 11.4173456393192 4067 1245 3765 783 240 4030 2905 723 217 1501 4422 1249 M11576 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. 8/16 Gene Ontology BP GO:1904406 0.109285651885986 0.196063864647076 1660 1811.09090909091 1502 0.0115064386877378 662 1.35593454827845 1.35593454827845 1 3.64196090890584 1658 662 3771 1038 2305 2819 2681 966 1332 1502 1188 1250 M13753 GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 15/48 Gene Ontology BP GO:0070873 0.0199133964032236 0.0658568552552914 1175 1670.27272727273 1502 0.00182690555503665 583 1.82051220676583 1.82051220676583 1 8.1638953568704 1502 1172 1376 1175 583 3171 2479 823 2150 2078 1864 1251 M16931 GO_PROTEIN_HETEROOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 84/185 Gene Ontology BP GO:0051291 0.0896467268896533 0.166758715123662 1935 1795.27272727273 1502 0.00850206424242317 861 1.46778240338295 1.46778240338295 1 4.33410149400059 1931 861 1198 1713 1261 4035 1181 1426 1502 2405 2235 1252 M16119 GO_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. 61/185 Gene Ontology BP GO:0006766 0.000664732068327586 0.00620996175703216 2575 1444.54545454545 1504 6.04484547954228e-05 70 1.14531564199034 1.22892827013657 1 9.5943875501038 2571 231 517 522 70 2784 3131 1504 738 1918 1904 1253 M12648 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation. 16/54 Gene Ontology BP GO:0002577 0.0839184282471183 0.158445571591463 470 1635.54545454545 1506 0.00793650793650794 469 1.70932184675759 1.70932184675759 1 5.19141973100576 469 2929 1572 2668 3042 1041 769 1283 602 2110 1506 1254 M15918 GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. 4/13 Gene Ontology BP GO:0002320 0.00760412170134462 0.0335607766723793 4335 2216.72727272727 1506 0.000763026790821214 31 2.24458518468169 2.24458518468169 1 12.5600191611507 4332 1506 4479 1094 343 4374 3321 471 31 1103 3330 1255 M16316 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. 10/23 Gene Ontology BP GO:0002888 0.0436661003122614 0.111826642994942 1125 1655.54545454545 1508 0.00405069729017552 699 1.11882204112119 1.11882204112119 1 4.04069775157994 1125 3577 2717 2343 900 1063 748 1508 1811 1720 699 1256 M16438 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 7/17 Gene Ontology BP GO:0032230 0.0439374701891298 0.112051654492429 1510 1868.81818181818 1508 0.00448311672823368 354 0.743128926420273 -0.743128926420273 -1 2.68139539422629 1508 1053 4565 906 1518 354 413 3679 1652 4500 409 1257 M11935 GO_REGULATION_OF_GLOMERULAR_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULAR_FILTRATION.html Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. 8/13 Gene Ontology BP GO:0003093 0.000577887321507742 0.00549821892164026 205 1366.63636363636 1510 5.78037655722635e-05 62 1.45023161899474 1.45023161899474 1 12.4397133119975 203 2320 3829 2344 2167 97 62 78 2225 1510 198 1258 M14732 GO_HISTONE_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving an mRNA encoding a histone. 14/31 Gene Ontology BP GO:0008334 0.0258465384862652 0.0784650926624202 1375 2074.54545454545 1510 0.00237775317661663 497 0.249341883294021 -0.24807549753535 -1 1.04614497448809 1374 2676 3275 3361 740 885 1376 497 3040 4086 1510 1259 M15457 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 267/655 Gene Ontology BP GO:0007169 0.0839184282471183 0.158445571591463 1260 1688.18181818182 1510 0.00793650793650794 916 1.32823383088347 1.44923436172354 1 4.03400876789256 1257 1510 1202 916 1894 3219 1650 2796 1068 930 2128 1260 M12164 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 8/16 Gene Ontology BP GO:0045019 0.118407352381916 0.209754039339656 1660 1823.27272727273 1511 0.0125234388604522 663 1.35593454827845 1.35593454827845 1 3.4910909126105 1659 663 3862 1039 2306 2820 2682 992 1333 1511 1189 1261 M16879 GO_INOSITOL_LIPID_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_LIPID_MEDIATED_SIGNALING.html A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. 64/158 Gene Ontology BP GO:0048017 0.0231800201615826 0.0728884748208125 1185 1427.09090909091 1511 0.00212981072898125 372 1.7519425752881 1.7519425752881 1 7.56341352180288 1182 372 1681 789 630 1813 1511 2035 1352 2002 2331 1262 M11115 GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 106/228 Gene Ontology BP GO:0044272 0.041504241078645 0.107776393360262 3150 1516.09090909091 1513 0.00384623342382751 25 1.3247456126028 -1.17096961329083 -1 4.86496903174702 3150 25 1207 1417 1649 213 1951 3161 1513 1753 638 1263 M12238 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 4/21 Gene Ontology BP GO:0051589 0.0765897756730953 0.158445571591463 1025 1801.54545454545 1513 0.00793650793650794 545 1.77228865595639 1.77228865595639 1 5.38265763994863 1024 3729 3872 1985 1763 1193 1513 2323 545 1093 777 1264 M10771 GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 17/41 Gene Ontology BP GO:0043537 0.0834004893644092 0.158445571591463 1125 1554.45454545455 1516 0.00788553031522085 511 1.19045135446987 1.19045135446987 1 3.6155465174851 1121 646 2167 511 1218 2795 1516 1909 1699 2141 1376 1265 M11743 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that modulates the frequency, rate or extent of extracellular matrix organization. 16/44 Gene Ontology BP GO:1903053 0.000244412611125049 0.00280199445297186 2820 1691.90909090909 1517 2.22217971608483e-05 43 1.73924633763958 1.73924633763958 1 16.8515420321061 2816 1036 1517 169 43 4097 2815 2067 356 1000 2695 1266 M12485 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. 59/127 Gene Ontology BP GO:2001243 0.00236310320887169 0.0146728659641204 1855 1477.18181818182 1517 0.000215058666459439 154 1.53739361430692 1.66690645535041 1 10.6996525974315 1853 1517 1957 921 154 3897 1714 1443 562 1844 387 1267 M14457 GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 298/724 Gene Ontology BP GO:0051493 0.0055531154890815 0.0269980264039847 3895 2207.18181818182 1518 0.000506107462056608 510 1.16250973247085 1.42446737144119 1 6.92205205411533 3892 918 510 1437 788 1518 4255 4044 1226 2219 3472 1268 M10110 GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS.html The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 507/1359 Gene Ontology BP GO:0048646 0.0307651077600477 0.0881199230906241 1515 1998.36363636364 1519 0.00311995176491725 285 1.35070599136579 1.47896483752938 1 5.40866407093405 1514 592 3534 993 1519 4568 2595 1798 1149 285 3435 1269 M14160 GO_AMELOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMELOGENESIS.html The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. 8/23 Gene Ontology BP GO:0097186 0.0125565416193905 0.0479047023326458 965 1919.27272727273 1519 0.0012628061066967 302 1.08023697533246 -1.08023697533246 -1 5.41097800918144 964 3763 4194 2783 4247 302 472 371 1969 1519 528 1270 M15097 GO_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of ions within an organism or cell. 272/819 Gene Ontology BP GO:0050801 3.46848246706433e-06 9.64321203268244e-05 1005 1395.90909090909 1520 3.15317085038789e-07 157 1.33169706001783 1.58713590524605 1 20.2993624886822 1001 1625 157 1238 1520 2110 1282 1868 1525 786 2243 1271 M13330 GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. 12/61 Gene Ontology BP GO:0006775 0.0188415935077958 0.0634383746604032 1525 1576.18181818182 1521 0.00172772012884953 408 0.516101935675163 0.692701734509366 1 2.34623708655272 1521 423 1813 1744 3970 1693 880 430 746 3710 408 1272 M15378 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. 14/41 Gene Ontology BP GO:0071526 0.0479218721951922 0.118890959210725 335 1872.18181818182 1521 0.00445442951729686 334 1.15898043917664 1.15898043917664 1 4.0686954859147 334 2119 777 2175 4601 1521 666 2316 3718 921 1446 1273 M16014 GO_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIOGENESIS.html Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. 54/139 Gene Ontology BP GO:0014013 0.094644398392368 0.174794726227432 535 1531.27272727273 1521 0.0089981343355307 484 0.939024370733805 0.939024370733805 1 2.69991748885986 531 1773 1521 1921 2319 1398 484 972 2300 2766 859 1274 M15587 GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS.html The process in which any suture between cranial and/or facial bones is generated and organized. 8/20 Gene Ontology BP GO:0097094 0.0338878214825682 0.0936554494902169 3290 2142.81818181818 1522 0.00344159655153921 305 0.870853979312018 0.870853979312018 1 3.39971812599241 3286 305 4429 868 822 1256 2708 3983 1323 1522 3069 1275 M14868 GO_MAST_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a mast cell. 10/51 Gene Ontology BP GO:0002448 0.0264109290870436 0.0794209480253521 655 1878.27272727273 1524 0.00243031134623847 253 0.561755500229623 0.624952145911158 1 2.3457022545999 654 2510 1524 2987 2557 833 253 916 3463 4120 844 1276 M10581 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. 21/36 Gene Ontology BP GO:2000108 0.0774546791144844 0.158445571591463 1000 1653.72727272727 1525 0.00730218815132552 856 1.66432443968961 1.66432443968961 1 5.05475709643647 1000 2457 856 1888 2530 1784 1430 1525 2563 1225 933 1277 M15829 GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING.html Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. 8/27 Gene Ontology BP GO:0060147 0.0153025483123481 0.0548223239307347 2550 1776.09090909091 1525 0.00154089566322562 145 1.35593454827845 1.35593454827845 1 6.49046333885489 2550 145 4464 634 539 982 802 2634 2611 1525 2651 1278 M15486 GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. 22/71 Gene Ontology BP GO:0035914 0.0226392850930216 0.0717503076361087 1305 1652 1526 0.00207960629069257 263 1.7193104527397 1.7193104527397 1 7.46714279900791 1304 2596 1578 1927 4430 2328 412 1526 538 1270 263 1279 M14909 GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. 19/58 Gene Ontology BP GO:0031952 0.00678699912849047 0.0309164982364579 1555 1446 1527 0.000618911627054064 308 1.56722812480193 1.56722812480193 1 8.98176441632357 1554 1938 1602 1308 308 3183 1783 1527 528 1124 1051 1280 M12742 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. 38/101 Gene Ontology BP GO:0032088 0.00739295467741219 0.0328788204666904 425 1432.81818181818 1528 0.000674355974947433 134 1.1607986166913 1.41813868093395 1 6.53476231061618 421 1634 2772 1528 4065 344 134 1576 635 1995 657 1281 M14240 GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. 51/152 Gene Ontology BP GO:0043255 0.0839184282471183 0.158445571591463 1530 1806.09090909091 1528 0.00793650793650794 777 1.66956475338577 1.66956475338577 1 5.07067257073489 1528 777 1294 1703 1464 3690 2824 1342 1105 2348 1792 1282 M16705 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. 24/61 Gene Ontology BP GO:0002763 0.161385165508919 0.258740097879113 1690 1596.18181818182 1528 0.0158730158730159 962 1.28983715113895 1.28983715113895 1 2.87462379584959 1406 1689 1167 1031 1911 2460 962 1687 1294 2423 1528 1283 M12320 GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). 25/43 Gene Ontology BP GO:0006891 0.00284992156014112 0.016755804355697 1295 1770.36363636364 1530 0.000259420010159223 45 0.271372671323996 -0.28405794713645 -1 1.82926187651691 1293 1530 3319 2878 204 45 353 2038 3994 3464 356 1284 M16741 GO_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 177/422 Gene Ontology BP GO:0009100 0.0146724530118229 0.0533053202925617 3790 1909.45454545455 1530 0.00134283922655607 10 1.22618458743202 1.27022439739642 1 5.92611065983767 3787 10 1020 1268 487 1727 3741 2041 1530 1239 4154 1285 M11326 GO_DEVELOPMENTAL_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_INDUCTION.html A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). 12/39 Gene Ontology BP GO:0031128 0.00651433248786923 0.0300955679016685 2500 1425.54545454545 1531 0.00059397292391561 100 1.62576134735484 -1.38916827744188 -1 9.38934411156635 2500 2532 1531 368 294 1599 704 2177 100 817 3059 1286 M16729 GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 13/23 Gene Ontology BP GO:0048569 0.010728933157439 0.0426493464469085 1290 1367 1531 0.000980146902943813 254 1.63581999531211 1.63581999531211 1 8.50728702240487 1288 1974 2202 1931 404 1942 811 1531 254 889 1811 1287 M16216 GO_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_MIGRATION.html The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. 8/26 Gene Ontology BP GO:0014812 0.0765897756730953 0.158445571591463 2680 1991.45454545455 1532 0.00793650793650794 72 2.46711003640163 2.46711003640163 1 7.49291524353179 2680 978 4528 361 3406 3537 900 1209 72 1532 2703 1288 M10398 GO_CELL_PART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PART_MORPHOGENESIS.html The process in which the anatomical structures of a cell part are generated and organized. 338/988 Gene Ontology BP GO:0032990 0.0395463194056384 0.104207469353223 2875 1961.54545454545 1533 0.00366141898067093 300 1.35004803450047 1.55431257435164 1 5.03283476167338 2873 593 778 1026 1533 2445 3965 2547 1021 300 4496 1289 M12355 GO_ATRIAL_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_DEVELOPMENT.html The progression of the atrial septum over time, from its initial formation to the mature structure. 9/26 Gene Ontology BP GO:0003283 0.0765897756730953 0.158445571591463 1535 1759.09090909091 1533 0.00793650793650794 339 1.70820157422404 1.70820157422404 1 5.18801732615965 1533 900 3895 1133 3443 1750 2024 1449 339 1597 1287 1290 M14433 GO_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANOIKIS.html Any process that modulates the frequency, rate or extent of anoikis. 32/78 Gene Ontology BP GO:2000209 0.0349005058025358 0.0955442502601261 415 1432.09090909091 1534 0.00322425273013818 294 1.67658560888596 1.67658560888596 1 6.4900199550038 411 2418 1534 2744 3387 425 294 645 1799 1746 350 1291 M10369 GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoclast differentiation. 41/137 Gene Ontology BP GO:0045670 0.0839184282471183 0.158445571591463 985 1847.63636363636 1535 0.00793650793650794 412 1.90802384955544 1.90802384955544 1 5.79490204178708 982 3346 1382 2099 4386 1535 1222 1014 412 2094 1852 1292 M10363 GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. 126/300 Gene Ontology BP GO:0045665 0.00368581452705844 0.0202284123512203 1025 1662.09090909091 1536 0.00033563674125297 468 1.32007364905172 1.32007364905172 1 8.48845386803245 1025 693 468 1357 1536 3528 2102 2130 2282 1140 2022 1293 M14014 GO_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYSTEM_PROCESS.html A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. 606/2821 Gene Ontology BP GO:0003008 0.00276565382595954 0.0164416526426762 625 1562.27272727273 1536 0.000276910184546578 122 1.44075956017062 1.48590486417845 1 9.75678794157146 621 913 4170 1065 1990 2481 1612 1536 1088 122 1587 1294 M14165 GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION.html Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. 24/46 Gene Ontology BP GO:0070570 0.0839184282471183 0.158445571591463 1070 1523.09090909091 1536 0.00793650793650794 239 1.61451714456469 1.61451714456469 1 4.90348624293464 1067 1536 1766 239 2295 1856 997 3508 584 1356 1550 1295 M15126 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. 22/42 Gene Ontology BP GO:1901797 0.0360366534676239 0.0971534283090433 1475 1601.36363636364 1537 0.00333098603950599 396 1.60640719314898 1.60640719314898 1 6.17413131357673 1473 3565 2537 1537 809 2204 1654 612 462 2366 396 1296 M16286 GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. 40/98 Gene Ontology BP GO:0003143 0.161385165508919 0.258740097879113 3935 2030.09090909091 1538 0.0158730158730159 1008 1.27950321373247 1.38289162926013 1 2.85159284008198 3933 1368 1079 1538 1872 1008 2801 2914 1465 1220 3133 1297 M16841 GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 8/24 Gene Ontology BP GO:0060260 0.026962978748512 0.0802494296982958 630 1528 1538 0.00272958279168128 77 1.70820157422404 1.70820157422404 1 7.1036530403413 628 1806 4624 1675 2149 261 273 3400 77 1538 377 1298 M10364 GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. 32/86 Gene Ontology BP GO:0048641 0.0721848997241189 0.158445571591463 2745 2003.72727272727 1539 0.00678802126859812 928 1.55178359343141 1.55178359343141 1 4.71295676729595 2741 1022 1297 928 1142 4221 3303 1442 1831 2575 1539 1299 M12311 GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. 17/50 Gene Ontology BP GO:0000060 0.0247369566638882 0.0760117073397966 1535 1871.27272727273 1540 0.00227450541388644 278 0.436854061712646 0.481339202310997 1 1.85575259693357 1531 887 2265 1540 4117 1105 725 3124 1549 3463 278 1300 M13694 GO_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. 21/60 Gene Ontology BP GO:0086003 0.161385165508919 0.258740097879113 925 1837 1540 0.0158730158730159 921 1.51548503002097 -1.42279293755586 -1 3.37751887960835 921 2421 1999 2734 4143 1252 1002 1332 1540 1229 1634 1301 M13989 GO_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSPORT.html The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 97/297 Gene Ontology BP GO:0006816 0.00668846318736852 0.0306862989910593 1540 1728 1540 0.00060989859052644 534 1.33693264420649 1.40110656142499 1 7.67841557996471 1280 1423 534 2036 2059 3735 1908 1539 1137 1540 1817 1302 M16062 GO_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_NUCLEUS.html A process in which a protein is transported to, or maintained in, a location within the nucleus. 89/234 Gene Ontology BP GO:0034504 0.0645814222140568 0.146900707449814 1285 1533.90909090909 1540 0.00605081717807073 766 1.25840162932597 1.37571450531698 1 3.97886359081123 1281 766 1907 1760 1090 2950 1540 928 1838 1980 833 1303 M10152 GO_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of neurological system. 333/2079 Gene Ontology BP GO:0050877 3.83695415927794e-06 0.000106041536675759 770 1426.63636363636 1541 3.48814622837382e-07 117 1.40706365873272 1.46493528068803 1 21.2278543832419 768 1565 158 1891 2491 2921 1837 893 1541 117 1511 1304 M12396 GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. 38/132 Gene Ontology BP GO:0040014 0.052234344826225 0.126487606846769 1050 1293.27272727273 1541 0.00486521779738767 426 1.42195890746904 1.42195890746904 1 4.84671419857032 1050 786 2177 922 1541 1694 1613 1593 426 1993 431 1305 M15736 GO_HEXOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 87/228 Gene Ontology BP GO:0019318 0.02326366553452 0.0729326124758788 3825 2154 1541 0.00213757902301955 634 1.21855416409645 1.32437322389975 1 5.2594752264394 3822 1361 1541 984 634 2022 4486 2238 1456 1287 3863 1306 M10180 GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. 62/154 Gene Ontology BP GO:0002244 0.0133792270260498 0.0501370065229614 2205 1969.63636363636 1542 0.0012237538101939 501 1.71891200465605 1.71891200465605 1 8.48108288471762 2204 3800 609 3349 501 3906 3035 808 1084 828 1542 1307 M13047 GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. 6/22 Gene Ontology BP GO:1903055 0.0335206215285915 0.0932003951166524 1545 1960.81818181818 1542 0.00340372583271289 300 0.308436182804199 -0.35743514079215 -1 1.20657745831119 1542 2723 3999 3247 1046 475 300 902 2444 3636 1255 1308 M14329 GO_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE.html Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. 505/1745 Gene Ontology BP GO:0006955 0.0765897756730953 0.158445571591463 740 1708.81818181818 1542 0.00793650793650794 419 1.30870962761131 1.38923472943556 1 3.97471137208908 738 1621 4225 1345 1542 2429 1184 2047 1168 419 2079 1309 M16254 GO_AXIS_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_ELONGATION.html The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. 17/43 Gene Ontology BP GO:0003401 0.0839184282471183 0.158445571591463 2810 1784.72727272727 1543 0.00793650793650794 139 1.91021908880517 1.91021908880517 1 5.80156925216492 2809 1543 1514 573 1522 3600 2049 1791 139 1045 3047 1310 M16422 GO_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING_BY_RNA.html Any process in which RNA molecules inactivate expression of target genes. 74/163 Gene Ontology BP GO:0031047 0.0417326133939291 0.108127524546882 660 2168.90909090909 1545 0.00386781255696254 380 0.30660994927239 -0.331685889141574 -1 1.12434412728996 656 3525 3233 4323 1023 380 1545 635 3173 4496 869 1311 M12559 GO_ATRIAL_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_MORPHOGENESIS.html The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. 8/20 Gene Ontology BP GO:0060413 0.069184929779718 0.154030287189733 1925 1688.54545454545 1546 0.00714382639816197 295 1.70820157422404 1.70820157422404 1 5.26760242762814 1922 665 3930 1005 1170 2220 2380 1546 295 1513 1928 1312 M10905 GO_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSPORT.html The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 218/695 Gene Ontology BP GO:0030001 0.00267749201813424 0.0161239888977915 1550 1836.45454545455 1548 0.000243705109179251 448 1.43308232232865 1.65588089623899 1 9.75088870091501 1546 996 448 1548 2943 3873 2121 2331 992 537 2866 1313 M11211 GO_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. 100/263 Gene Ontology BP GO:0042593 0.00515157108042123 0.0255542142376023 560 1376.18181818182 1551 0.000469424892142134 264 1.30975101377907 1.47811878929798 1 7.91745554131854 558 2000 1117 1910 264 1882 1551 1097 2383 1572 804 1314 M13820 GO_RESPONSE_TO_CAFFEINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAFFEINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. 10/34 Gene Ontology BP GO:0031000 0.135452508835328 0.233714779473943 1370 2393 1551 0.0131445764307016 665 0.455777087998454 0.632223716652657 1 1.09220715943934 1369 3790 1551 4103 3500 1242 665 1015 3887 3841 1360 1315 M10392 GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 8/18 Gene Ontology BP GO:0009151 0.0799839333266615 0.158445571591463 1460 1864 1552 0.00830176298473764 741 0.55936453995665 -0.55936453995665 -1 1.69885859404468 1456 2276 3577 1862 1252 852 1276 1552 2645 3015 741 1316 M12081 GO_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSPORT.html The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 198/632 Gene Ontology BP GO:0006820 8.45705671577201e-05 0.00126257602351542 900 1620 1552 7.68852893854342e-06 251 1.55479113806216 1.60157767448156 1 17.1075934101859 899 1076 251 1023 1936 3639 1916 1856 1487 1552 2185 1317 M14445 GO_CARBOHYDRATE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. 100/263 Gene Ontology BP GO:0033500 0.00515157108042123 0.0255542142376023 560 1373.63636363636 1552 0.000469424892142134 265 1.30975101377907 1.47811878929798 1 7.91745554131854 559 2001 1118 1911 265 1883 1552 1059 2384 1573 805 1318 M14586 GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. 7/27 Gene Ontology BP GO:0051580 0.0353703978790938 0.096206653399316 1265 1790.72727272727 1553 0.00359463211802806 842 1.38933387508025 1.38933387508025 1 5.36225190164531 1264 1553 4253 1474 842 1969 1738 1018 2192 1420 1975 1319 M10221 GO_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 75/226 Gene Ontology BP GO:0045471 0.00262079166616285 0.0159271409764321 2695 1955.18181818182 1556 0.000238538086429716 444 1.66799886031433 -0.816391131298516 -1 11.383069206753 2694 607 444 915 1292 3215 2594 1556 1189 2842 4159 1320 M12532 GO_SECRETORY_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. 18/40 Gene Ontology BP GO:0033363 0.0221107391824299 0.0704599602086631 1560 2036.90909090909 1556 0.00203055795001246 585 0.94175740835774 0.94175740835774 1 4.11832363247005 1556 3660 2654 3528 615 705 585 729 3697 3513 1164 1321 M11560 GO_SULFATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATION.html The addition of a sulfate group to a molecule. 5/26 Gene Ontology BP GO:0051923 0.00679190786155224 0.0309164982364579 1255 1600.72727272727 1557 0.000681275610274422 320 0.990478194536085 0.990478194536085 1 5.67641791385726 1254 1557 3769 1858 320 1950 1019 1116 1665 1191 1909 1322 M12115 GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY.html The formation or destruction of chromatin structures. 96/208 Gene Ontology BP GO:0006333 0.00575191159105993 0.0276747414686956 85 1758.27272727273 1557 0.00052427320642759 85 1.2451718004747 -1.2451718004747 -1 7.36343850923216 85 2769 1244 2764 2608 980 1557 1266 2309 2546 1213 1323 M11251 GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic hydroxy compound. 212/648 Gene Ontology BP GO:1901615 0.00122079330200376 0.00899705285905312 2145 1909.27272727273 1558 0.000111042841302425 388 1.24994188656082 -0.97324749483344 -1 9.70691881866806 2143 689 388 1547 1275 3712 2098 2730 1558 1054 3808 1324 M13824 GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. 13/40 Gene Ontology BP GO:0046885 0.0220703253835147 0.0703794785409744 3265 1898.90909090909 1558 0.00202680859642108 390 1.38925107626107 -1.38916827744188 -1 6.07783965572625 3262 1116 1558 913 4457 3028 2652 474 390 880 2158 1325 M14317 GO_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. 301/765 Gene Ontology BP GO:0005975 0.0839184282471183 0.158445571591463 3280 1938.81818181818 1558 0.00793650793650794 594 1.4664789787203 1.66786995798347 1 4.45387620806 3277 594 1106 803 1317 1558 3469 2021 811 1922 4449 1326 M14703 GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. 10/18 Gene Ontology BP GO:0045653 0.169658670004129 0.27013895913209 890 1910.36363636364 1560 0.0167596427209174 887 0.554949060682058 -0.60674671760311 -1 1.1973584512275 887 2134 1560 2435 1999 890 1525 1124 3305 4075 1080 1327 M10690 GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an alpha-amino acid. 35/84 Gene Ontology BP GO:1901607 0.0839184282471183 0.158445571591463 1565 1904.09090909091 1561 0.00793650793650794 969 1.13533089743152 -1.41448702878402 -1 3.44813894072974 1561 3277 2558 3307 2527 1025 1269 1189 969 1896 1367 1328 M10879 GO_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SECRETION.html The controlled release of proteins from a cell. 57/190 Gene Ontology BP GO:0009306 0.0308778770582023 0.0882228427891537 3110 2186.72727272727 1561 0.00284727019414478 548 2.04696961600723 2.04696961600723 1 8.19279014461746 3110 2447 1237 1366 1561 4175 4587 552 548 1113 3358 1329 M16268 GO_NEGATIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DEATH.html Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. 114/276 Gene Ontology BP GO:1901215 0.0146227210545686 0.0532079105457381 1705 1500.27272727273 1564 0.00133825708291914 486 1.38257669045629 1.4668156115006 1 6.6861174494086 1705 1922 783 935 486 2406 1564 831 2226 1368 2277 1330 M12324 GO_ANATOMICAL_STRUCTURE_REGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_REGRESSION.html The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. 9/20 Gene Ontology BP GO:0060033 0.0765897756730953 0.158445571591463 2115 1700.81818181818 1566 0.00793650793650794 318 1.5451534114364 -1.38975139692581 -1 4.69282009280395 2115 2273 3890 831 1566 1756 610 1502 318 676 3172 1331 M12544 GO_IN_UTERO_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IN_UTERO_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. 168/428 Gene Ontology BP GO:0001701 0.087358950935776 0.163222377945597 3815 2233 1566 0.00827580461063129 761 1.19795552210508 1.20802509156011 1 3.57968003189138 3814 761 941 1006 1250 2504 4281 3570 1566 1106 3764 1332 M12884 GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. 32/73 Gene Ontology BP GO:0019935 0.154830872664345 0.258496850694195 1205 1742.81818181818 1571 0.0151762549080531 1011 0.989700013025351 -0.665455983212677 -1 2.20725115267144 1204 1021 1043 1829 2030 2264 1011 1082 3538 2578 1571 1333 M14398 GO_CELLULAR_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, as carried out by individual cells. 437/1131 Gene Ontology BP GO:0044255 0.0320793514907442 0.0904127814474693 3540 2218.45454545455 1571 0.00295971771455243 726 1.23340293439402 1.4551595768125 1 4.88671588012555 3537 1066 726 1064 764 2477 3833 3840 1514 1571 4011 1334 M14821 GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 25/58 Gene Ontology BP GO:0010799 0.0839184282471183 0.158445571591463 3385 2180.18181818182 1571 0.00793650793650794 98 2.34259311853386 2.34259311853386 1 7.11474211861035 3384 1378 1571 958 2335 4136 4043 1001 98 1385 3693 1335 M16757 GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 51/105 Gene Ontology BP GO:0002088 0.00671464699084288 0.0307695384735218 1585 1689.63636363636 1572 0.000612293531505959 305 1.54738029990102 1.54738029990102 1 8.88017111396048 1583 381 1621 979 305 2732 1572 4612 832 1556 2413 1336 M10831 GO_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. 6/28 Gene Ontology BP GO:0046068 0.182278290666004 0.285628789592391 1155 2238.63636363636 1573 0.019922198213028 1155 1.31505585488108 1.31505585488108 1 2.7164917346551 1155 3122 3643 3629 2944 1173 1162 1196 3719 1309 1573 1337 M11902 GO_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/164 Gene Ontology BP GO:0002028 0.161385165508919 0.258740097879113 1120 1674.90909090909 1573 0.0158730158730159 776 1.28549766658249 1.28549766658249 1 2.86495250861968 1120 776 1267 1375 3283 2161 1624 1105 1573 2375 1765 1338 M12067 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 6/15 Gene Ontology BP GO:0040037 0.0349738319649562 0.0956885691298123 2380 1843.81818181818 1574 0.00355367677895358 104 1.42750535851956 -1.38916827744188 -1 5.52228479019406 2377 748 3845 382 836 3638 4568 1711 104 499 1574 1339 M12788 GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. 15/24 Gene Ontology BP GO:1903671 0.0839184282471183 0.158445571591463 1415 1743.72727272727 1574 0.00793650793650794 516 1.19045135446987 1.19045135446987 1 3.6155465174851 1411 815 2627 968 1574 2952 2281 2565 516 2070 1402 1340 M13979 GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 84/208 Gene Ontology BP GO:0090090 0.0133457465008051 0.0500924017811142 2060 1942 1575 0.00122067267447625 366 1.55192152928373 1.59260984224419 1 7.65943176554142 2057 1213 1575 1532 1323 3852 3653 366 1769 1241 2781 1341 M15497 GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. 25/80 Gene Ontology BP GO:0042149 0.000233118026510539 0.00272959819758131 1575 1534.54545454545 1575 2.11947938182088e-05 40 1.83657157317686 1.83657157317686 1 17.8737791611013 1575 2595 672 1583 40 3404 3125 69 2517 793 507 1342 M10063 GO_CARDIAC_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_ADAPTATION.html The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. 9/17 Gene Ontology BP GO:0014887 0.0780311911176495 0.158445571591463 1615 1869.72727272727 1576 0.0080914749341467 971 1.70820157422404 1.70820157422404 1 5.18801732615965 1615 1048 3529 971 1236 1413 1537 3798 1709 1576 2135 1343 M14726 GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT.html The directed movement of substances from early endosomes to the Golgi. 11/16 Gene Ontology BP GO:0034498 0.17311114997712 0.274047850792458 1230 1615 1579 0.0171320033203594 745 1.69748649654937 1.69748649654937 1 3.62229658037802 1226 1862 2992 1579 1623 979 745 1493 2323 1807 1136 1344 M12838 GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 73/173 Gene Ontology BP GO:0010594 0.113822493303065 0.20279272310289 1405 1749.36363636364 1580 0.0109251551623234 933 1.3497695455964 1.3497695455964 1 3.55031814274614 1401 933 944 1233 2256 3439 1619 1580 2050 1026 2762 1345 M14701 GO_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGING.html An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). 53/113 Gene Ontology BP GO:0007569 0.0266075931751833 0.0797535465009727 1585 1480.54545454545 1581 0.00244863195124373 507 1.46093429783984 1.53857588087237 1 6.09030617434134 1581 1576 1744 1017 1595 3135 2125 507 750 672 1584 1346 M16320 GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 11/23 Gene Ontology BP GO:0046325 0.00785385695723897 0.034433860106195 2250 1642.18181818182 1581 0.000716548695585829 373 1.82051220676583 1.82051220676583 1 10.1099589976102 2248 422 549 373 830 4023 3806 710 1700 1822 1581 1347 M12077 GO_NEGATIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BINDING.html Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 25/89 Gene Ontology BP GO:0043392 0.030650577972415 0.087954656072882 1585 1686.90909090909 1582 0.00282601124059037 404 1.27872827262329 1.27872827262329 1 5.12439919614151 1582 404 1564 1467 736 2415 1487 1809 1836 2438 2818 1348 M10406 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 9/20 Gene Ontology BP GO:0038084 0.0765897756730953 0.158445571591463 970 1670.45454545455 1583 0.00793650793650794 276 2.46711003640163 2.46711003640163 1 7.49291524353179 966 1986 3580 1091 2850 1511 874 1635 276 1583 2023 1349 M10877 GO_MODIFIED_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSPORT.html The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/36 Gene Ontology BP GO:0072337 0.125037457903019 0.218770275577925 1795 1797.54545454545 1585 0.0120696792962486 984 1.34349992948527 1.34349992948527 1 3.36586353653255 1793 1042 1338 1388 4435 1585 2016 984 1263 1855 2074 1350 M11929 GO_RESPONSE_TO_INTERFERON_ALPHA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_ALPHA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. 18/37 Gene Ontology BP GO:0035455 0.00109945016496701 0.00830040181453953 1685 1287.54545454545 1585 1e-04 42 1.34215570283714 1.34215570283714 1 10.6013586375215 1681 808 1934 42 1585 2645 2715 320 74 565 1794 1351 M12677 GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. 29/63 Gene Ontology BP GO:0009201 0.0839184282471183 0.158445571591463 670 1694 1586 0.00793650793650794 457 0.278018906826592 -0.275805108561336 -1 0.844377459386476 669 1586 3414 2279 1676 457 1204 1607 1228 3550 964 1352 M14045 GO_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 155/420 Gene Ontology BP GO:0006631 0.00899966762124405 0.0376445556445371 1820 1845.18181818182 1586 0.000821517756169112 562 1.11268372201546 1.35589003846012 1 6.01561144206347 1816 998 562 1152 1290 3840 1586 2019 1536 2174 3324 1353 M16883 GO_POSITIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIOGENESIS.html Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. 26/67 Gene Ontology BP GO:0014015 0.00599223335031349 0.0283897341280669 715 1885.36363636364 1587 0.000546237923643844 248 0.751564534681695 0.751564534681695 1 4.41284355609578 711 2627 1587 2384 2910 1381 712 248 2841 4620 718 1354 M12279 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE.html Any process that modulates the size of an anatomical structure. 270/671 Gene Ontology BP GO:0090066 4.81123244921492e-05 0.000815275629989229 960 1431.18181818182 1588 4.37394333675086e-06 226 1.15219719215922 1.24273905529943 1 13.5085627494819 956 474 226 597 2098 2742 1588 2146 1159 1895 1862 1355 M14618 GO_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 7/33 Gene Ontology BP GO:0072215 0.00166712148594546 0.0113164401450947 3320 1803.45454545455 1588 0.000166837349039055 57 2.46711003640163 2.46711003640163 1 18.2265025273227 3320 437 4260 127 134 3073 2017 1588 57 1421 3404 1356 M16735 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL.html The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. 18/73 Gene Ontology BP GO:0003044 0.106418303838493 0.191883566882378 1130 1975.18181818182 1588 0.0101767280514701 745 0.858982002181133 0.858982002181133 1 2.33769347693575 1128 1441 1588 2011 3831 1033 1817 921 2635 4577 745 1357 M11430 GO_RESPONSE_TO_AXON_INJURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AXON_INJURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. 36/74 Gene Ontology BP GO:0048678 0.0839184282471183 0.158445571591463 2280 1702 1589 0.00793650793650794 346 1.58564322739937 1.88359213989927 1 4.81579262129579 2278 1225 1098 949 1820 4294 1589 1114 346 1912 2097 1358 M10114 GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 8/25 Gene Ontology BP GO:0090185 0.0765897756730953 0.158445571591463 2160 1942.72727272727 1590 0.00793650793650794 80 1.80540289925521 1.80540289925521 1 5.48322965122361 2157 1291 3535 865 1590 2592 3542 2673 80 1490 1555 1359 M16328 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. 25/69 Gene Ontology BP GO:0051155 0.0839184282471183 0.158445571591463 1805 1754.63636363636 1591 0.00793650793650794 413 1.54444415987415 1.54444415987415 1 4.69066600897145 1803 1325 1132 570 3821 4545 1789 1591 413 424 1888 1360 M11960 GO_GLUTAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. 9/24 Gene Ontology BP GO:0006541 0.214139132665174 0.322775948981753 725 1861.18181818182 1592 0.0238095238095238 706 1.59008010255122 -1.59008010255122 -1 2.96411559661032 722 3026 3833 3203 1823 706 1494 1267 1763 1592 1044 1361 M10273 GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON.html A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. 17/38 Gene Ontology BP GO:0044380 0.0333497843975779 0.0930291037311123 1160 2010.36363636364 1593 0.00307875725521625 235 0.493393016758395 -0.493393016758395 -1 1.93160990955349 1156 3885 3007 3542 1593 235 761 989 3616 2991 339 1362 M14303 GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-RNA complex into its constituent components. 10/17 Gene Ontology BP GO:0032988 0.0285892035620708 0.0833679666089529 795 1652.18181818182 1594 0.00263342052363142 268 0.335807184838392 -0.395059170891142 -1 1.37536819773772 794 2132 3111 2775 1594 314 268 533 2061 3975 617 1363 M15424 GO_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 139/358 Gene Ontology BP GO:0009636 0.000701940183980312 0.00642822144816684 870 1478.54545454545 1594 6.38331134290789e-05 349 1.67578404860002 1.76793989951975 1 13.9427306265389 866 2698 349 2010 642 2725 708 1778 1865 1029 1594 1364 M13918 GO_RETINOIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. 6/33 Gene Ontology BP GO:0042573 0.00894943138962551 0.0375358716730183 720 1793.45454545455 1595 0.000898567855190048 149 0.605470584841159 0.673085334831407 1 3.27630103483319 719 1749 4157 1595 4211 1897 149 312 575 3875 489 1365 M13049 GO_CILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 109/278 Gene Ontology BP GO:0044782 0.00167912634603175 0.0113646991612616 480 1723.54545454545 1596 0.000152764481113094 26 0.928825529591201 -0.644756392804276 -1 6.85545652041554 476 1513 3223 2629 3131 26 792 1596 2579 2810 184 1366 M14116 GO_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_MIGRATION.html The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. 27/59 Gene Ontology BP GO:0008347 0.0839184282471183 0.158445571591463 2145 1911.54545454545 1596 0.00793650793650794 576 1.68858669975884 1.68858669975884 1 5.12844455084149 2142 2490 1596 576 2892 4491 1408 2484 641 1475 832 1367 M14749 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN.html An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. 15/224 Gene Ontology BP GO:0002455 0.135512164561329 0.2337232466784 1185 1730.18181818182 1598 0.0131507671020614 565 1.04153308372933 -0.964244126337474 -1 2.49582870715549 1185 1598 1078 1515 3411 1845 565 2180 2231 2082 1342 1368 M12273 GO_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_PAIN.html The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. 38/149 Gene Ontology BP GO:0019233 0.0489906391297593 0.12060632952252 1105 1740.27272727273 1599 0.00455607792577357 782 1.61112816865721 1.61112816865721 1 5.61795037431057 1105 2918 782 2506 2136 2064 1156 1599 1542 1992 1343 1369 M14962 GO_ENDODERM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_FORMATION.html The formation of the endoderm during gastrulation. 37/84 Gene Ontology BP GO:0001706 0.00313188915405505 0.0179653064479894 640 1766.54545454545 1602 0.000285123324885506 458 1.46778240338295 1.46778240338295 1 9.72534519761841 639 2663 458 2507 2067 2141 1530 1402 3307 1116 1602 1370 M12765 GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive nitrogen species. 9/26 Gene Ontology BP GO:2001057 0.000960913041976593 0.00791753767816902 2240 1910.54545454545 1603 9.61328804266191e-05 97 1.12661700765753 -0.938178160433969 -1 8.98657700633645 2238 140 3957 605 97 1603 3219 4617 1956 1599 985 1371 M13793 GO_REGULATION_OF_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION.html Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. 13/63 Gene Ontology BP GO:0051931 0.0423343113751387 0.109077806722957 285 1782 1603 0.00392469000714535 285 0.858982002181133 0.858982002181133 1 3.1375117050899 285 1603 756 1649 2353 1371 1897 1253 3077 3835 1523 1372 M13732 GO_CELLULAR_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 16/40 Gene Ontology BP GO:0071361 0.000586023695772381 0.00556422907867314 1105 1813.45454545455 1604 5.32890777932595e-05 76 0.545650546201028 0.629367381842678 1 4.66971488028228 1101 650 746 1604 2228 3492 949 76 3406 3820 1876 1373 M16918 GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN.html Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. 13/63 Gene Ontology BP GO:0051930 0.0423343113751387 0.109077806722957 290 1854.18181818182 1604 0.00392469000714535 286 0.858982002181133 0.858982002181133 1 3.1375117050899 286 1604 757 1650 2354 1372 1898 1242 3078 4631 1524 1374 M15479 GO_NEGATIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. 148/388 Gene Ontology BP GO:0007162 3.96129794674601e-06 0.000107557347173928 390 1457.72727272727 1607 3.60118643585215e-07 161 1.26195927025641 1.26195927025641 1 19.0091905350668 389 1921 161 1905 2099 2519 1212 1275 1607 1134 1813 1375 M10218 GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of leukocyte proliferation. 118/335 Gene Ontology BP GO:0070663 0.00132991018375275 0.00961802645352648 1610 1612.27272727273 1609 0.000120974072877334 395 1.20509413842239 1.22902177575825 1 9.22604551364824 1609 1079 395 686 1655 2935 1645 2387 1214 1457 2673 1376 M13805 GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. 9/17 Gene Ontology BP GO:0003299 0.0780311911176495 0.158445571591463 1620 1929 1609 0.0080914749341467 972 1.70820157422404 1.70820157422404 1 5.18801732615965 1616 1049 4134 972 1237 1414 1538 3804 1710 1609 2136 1377 M10834 GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that activates or increases the frequency, rate or extent of membrane invagination. 9/22 Gene Ontology BP GO:1905155 0.213896101946211 0.322775948981753 970 1904.36363636364 1612 0.0237793389162874 757 1.9083122944764 1.9083122944764 1 3.55734168752975 969 1612 3644 1701 4299 1367 757 1440 1785 1587 1787 1378 M14341 GO_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_APOPTOTIC_PROCESS.html Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 31/69 Gene Ontology BP GO:0051402 0.060010475824464 0.139384011632309 2205 1811.81818181818 1612 0.00561025326269936 527 1.76309077669793 1.76309077669793 1 5.72726937244564 2205 3141 1612 1580 2021 3750 2244 735 527 550 1565 1379 M15957 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. 31/133 Gene Ontology BP GO:0002440 0.000206493968238987 0.00250326760974835 1530 1506.54545454545 1612 1.87739411358934e-05 36 1.21823644267662 1.21823644267662 1 12.0298838155805 1530 2665 2027 1612 36 2123 1565 313 1774 954 1973 1380 M11203 GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 5/13 Gene Ontology BP GO:0009313 0.0765897756730953 0.158445571591463 1615 1612.72727272727 1614 0.00793650793650794 13 2.06322935667965 2.06322935667965 1 6.26628016966936 1650 1134 3709 177 3587 1615 1319 1614 13 1189 1733 1381 M10928 GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 13/28 Gene Ontology BP GO:0015986 0.104473385232413 0.18900991267086 860 1896.27272727273 1615 0.00998106768606719 656 0.206313947354551 -0.219597159451822 -1 0.566609184486124 856 1657 3434 2645 1330 656 1615 1422 3224 3121 899 1382 M14759 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 9/22 Gene Ontology BP GO:0060100 0.213896101946211 0.322775948981753 1615 1967 1615 0.0237793389162874 758 1.9083122944764 1.9083122944764 1 3.55734168752975 970 1613 4289 1702 4300 1368 758 1448 1786 1615 1788 1383 M12843 GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. 13/28 Gene Ontology BP GO:0015985 0.104473385232413 0.18900991267086 860 1953.45454545455 1616 0.00998106768606719 657 0.206313947354551 -0.219597159451822 -1 0.566609184486124 857 1658 3435 2646 1331 657 1616 1578 3225 3585 900 1384 M13372 GO_PHOSPHATE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSPORT.html The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/20 Gene Ontology BP GO:0006817 0.00303736336124651 0.0176280976078344 1295 1753.54545454545 1616 0.000304152287426582 181 0.443916554678951 0.609276343343752 1 2.95520279762038 1291 1616 4062 2368 288 2165 1739 181 565 3721 1293 1385 M11626 GO_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 444/1387 Gene Ontology BP GO:0050776 0.00125453209290579 0.00918736988542836 1055 1711.54545454545 1617 0.000114113459205711 390 1.23189412672663 1.31406686088883 1 9.52425200637755 1051 1821 390 1534 1857 3323 1498 1432 1617 2000 2304 1386 M16881 GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. 9/17 Gene Ontology BP GO:0014898 0.0780311911176495 0.158445571591463 1620 1976 1617 0.0080914749341467 973 1.70820157422404 1.70820157422404 1 5.18801732615965 1617 1050 4630 973 1238 1415 1539 3789 1711 1637 2137 1387 M13496 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune system process. 722/2113 Gene Ontology BP GO:0002682 0.0765897756730953 0.158445571591463 685 1766 1619 0.00793650793650794 684 1.28366585999269 1.35577099398817 1 3.89865038357186 684 1619 4086 1737 1891 2940 1112 1232 1215 1107 1803 1388 M15322 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein. 9/31 Gene Ontology BP GO:0042522 0.0260631342386601 0.0788860053911989 1165 1867.45454545455 1621 0.00263739564360925 512 1.21455215107271 1.21455215107271 1 5.08509329015626 1165 3110 4385 1943 2894 740 1029 528 2615 1621 512 1389 M16689 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. 11/23 Gene Ontology BP GO:0034391 0.0166558572386392 0.0582327900293687 1575 1969.54545454545 1621 0.00152575537161422 405 0.453417721205618 0.54196013734584 1 2.1252681690598 1574 737 2346 980 3546 1984 1621 405 2636 4566 1270 1390 M11769 GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. 177/373 Gene Ontology BP GO:0006520 0.0229988355202818 0.0724447715879703 1195 1493.90909090909 1622 0.00211298586364668 236 1.15496265916741 -1.00858284899555 -1 4.99778237291221 1193 2239 1958 2509 627 236 1641 1291 1622 2448 669 1391 M12966 GO_PHOTORECEPTOR_CELL_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_MAINTENANCE.html Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. 17/52 Gene Ontology BP GO:0045494 0.027513177061845 0.0811070991099343 2460 1804.90909090909 1622 0.00253303673089554 87 1.56990405025196 1.88278454173833 1 6.50102231977397 2458 2567 1718 1622 703 4147 3731 1379 87 531 911 1392 M13855 GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION.html The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. 19/34 Gene Ontology BP GO:0043687 0.034384670684266 0.0945782144473027 1625 2108.72727272727 1622 0.00317583124489306 233 0.757413120848284 -0.757413120848284 -1 2.94461551576909 1622 3246 3034 3991 786 233 1051 1384 3384 3855 610 1393 M14026 GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT.html The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. 642/1793 Gene Ontology BP GO:0006928 0.00434369582816881 0.0227627310724467 1195 1935.18181818182 1622 0.000435220972135033 146 1.41051158072669 1.4991294092695 1 8.79553253764057 1191 1064 4173 1025 1622 4468 2242 1818 1073 146 2465 1394 M14904 GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION.html A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. 334/995 Gene Ontology BP GO:0003006 0.00183772347510247 0.0121373401065445 2065 1668.36363636364 1622 0.000167205488744484 219 1.50474204265759 1.57702070870323 1 10.9430098959401 2061 1622 419 423 228 4212 2278 2663 847 219 3380 1395 M11940 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. 50/126 Gene Ontology BP GO:0048640 0.00699888524700462 0.0314272961333099 1625 1574.90909090909 1623 0.000638295505090294 220 1.45384840252029 1.45384840252029 1 8.29271257168637 1623 615 540 220 1940 3731 2294 3244 757 388 1972 1396 M13507 GO_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASODILATION.html An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. 18/34 Gene Ontology BP GO:0042311 0.0920797334679898 0.17046499301909 990 1620.81818181818 1623 0.00874325497696619 564 1.38364714832877 1.38364714832877 1 4.03552499441842 990 1650 1156 2375 1567 1623 577 3407 1720 2200 564 1397 M13737 GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. 2/18 Gene Ontology BP GO:0021892 0.00344892952064776 0.019316501525172 2310 1944.7 1624.5 0.000383803083043267 203 1.14672566625037 1.14672566625037 1 7.46097706538995 2306 988 4125 NA 662 3495 3568 203 1915 851 1334 1398 M10844 GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 141/312 Gene Ontology BP GO:0034976 0.00179925726437227 0.0119512896687846 1950 1614.36363636364 1626 0.000163702769415705 30 1.13626871659248 1.28771871734247 1 8.29227854516256 1948 1626 3141 2181 363 30 1535 1200 2696 2869 169 1399 M15543 GO_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. 93/196 Gene Ontology BP GO:0006643 0.161385165508919 0.258740097879113 2025 1741.18181818182 1627 0.0158730158730159 588 1.20899543759568 -0.969225090285419 -1 2.6944541416744 2021 1267 2652 1592 1750 588 1627 2069 1579 2528 1480 1400 M16601 GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 132/322 Gene Ontology BP GO:0034599 0.000797905513736879 0.00697678964271249 2090 1829.54545454545 1628 7.25631862348549e-05 356 1.48722582606207 1.62351341999958 1 12.1731302536064 2086 1628 356 1505 991 3429 1928 2681 1599 1274 2648 1401 M12211 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. 14/40 Gene Ontology BP GO:0099623 0.121125730660877 0.213429513266965 1630 1796.18181818182 1629 0.0116689678112512 445 1.39024051586687 -1.28127221255727 -1 3.53960627738637 1629 1600 1263 1428 1860 2444 3202 1755 1362 445 2770 1402 M10224 GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of cell cycle checkpoint. 24/42 Gene Ontology BP GO:1901976 0.0281601224025594 0.0824384920019439 1635 1748.09090909091 1631 0.00259337891972192 523 0.295978688640566 -0.291158355472281 -1 1.21771274880789 1631 1381 3299 2221 710 523 655 1864 3343 2981 621 1403 M14392 GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoblast differentiation. 80/162 Gene Ontology BP GO:0045667 0.0839184282471183 0.158445571591463 1095 1619.54545454545 1632 0.00793650793650794 898 1.36637371898521 1.35483065988589 1 4.14984427775398 1094 1724 898 1184 2657 1419 1632 2440 1002 1740 2025 1404 M10832 GO_ADULT_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_BEHAVIOR.html Behavior in a fully developed and mature organism. 56/246 Gene Ontology BP GO:0030534 0.0839184282471183 0.158445571591463 1635 1699.36363636364 1633 0.00793650793650794 715 1.51933302609756 1.519329458782 1 4.61440042118443 1633 2522 1120 1086 1532 2567 2086 1805 740 715 2887 1405 M14499 GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 70/172 Gene Ontology BP GO:0044262 0.0839184282471183 0.158445571591463 2765 2071 1633 0.00793650793650794 543 2.00389745263357 2.25889861850582 1 6.08608191271867 2762 1087 1633 1387 1505 3701 3077 2059 543 1444 3583 1406 M16401 GO_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. 9/19 Gene Ontology BP GO:0070231 0.00130890667766328 0.00952547602569061 1775 1735.90909090909 1633 0.000130967827388433 88 1.86280643978199 1.86280643978199 1 14.2910988824621 1771 2435 4559 1617 325 2586 3490 118 88 1633 473 1407 M16446 GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT.html The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. 24/58 Gene Ontology BP GO:0031076 0.0839184282471183 0.158445571591463 2365 1654.09090909091 1633 0.00793650793650794 353 1.41682755129217 1.53152794083051 1 4.30307874383712 2365 1326 1101 1633 2605 2673 1671 1165 353 404 2899 1408 M16078 GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of B cell activation. 34/210 Gene Ontology BP GO:0050871 0.0120191332901038 0.0460816150833625 3325 1962.09090909091 1637 0.00109866394453638 440 1.3809894040836 1.3809894040836 1 7.00579688575604 3324 1637 1053 693 440 4372 2213 2474 780 1033 3564 1409 M11794 GO_COPPER_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_TRANSPORT.html The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/20 Gene Ontology BP GO:0006825 0.0839184282471183 0.158445571591463 1880 1468.45454545455 1638 0.00793650793650794 132 1.21831602395311 -0.930896232997513 -1 3.70017493034519 1877 132 1647 464 3146 1638 2218 2895 372 769 995 1410 M16392 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 3/14 Gene Ontology BP GO:0045086 0.048571538655971 0.119828721561994 2300 1904.81818181818 1638 0.00496670295909962 586 0.613806821771645 -0.653178482202762 -1 2.14686910704724 2297 586 4558 1663 995 867 1638 1036 1972 4488 853 1411 M14928 GO_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. 43/111 Gene Ontology BP GO:0030510 0.0335207830568446 0.0932003951166524 2030 1810.27272727273 1639 0.00309479068527176 454 1.43996171239129 1.60172607970257 1 5.63301402386265 2028 1838 1384 1639 780 4453 2704 874 454 814 2945 1412 M16129 GO_NEGATIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXONOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. 45/105 Gene Ontology BP GO:0050771 0.0215715716868445 0.0691690658439358 865 1513.18181818182 1640 0.001980548766209 247 1.39267221548956 1.39267221548956 1 6.13263490228499 863 247 667 618 2140 3038 1640 3080 1753 527 2072 1413 M11094 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO.html The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. 5/18 Gene Ontology BP GO:0008595 0.00957391924823617 0.0392592104060817 3680 2233.09090909091 1641 0.000961541806592631 397 1.2692844111372 -1.07272638267715 -1 6.77437991524017 3679 577 3687 1083 397 3371 1353 4176 1641 439 4161 1414 M11843 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). 255/684 Gene Ontology BP GO:0032787 0.00023330653540023 0.00272959819758131 2980 1924.27272727273 1642 2.12119346240796e-05 1 1.21421303325463 1.42524036878029 1 11.8168961818751 2976 1 291 519 1194 2756 3005 2647 1575 1642 4561 1415 M14898 GO_TRIPARTITE_REGIONAL_SUBDIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIPARTITE_REGIONAL_SUBDIVISION.html Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. 5/18 Gene Ontology BP GO:0007351 0.00957391924823617 0.0392592104060817 3680 2290.27272727273 1642 0.000961541806592631 398 1.2692844111372 -1.07272638267715 -1 6.77437991524017 3680 578 4312 1084 398 3372 1354 4170 1642 441 4162 1416 M15850 GO_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEATH.html The process of cell death in a neuron. 40/89 Gene Ontology BP GO:0070997 0.00148893101871357 0.0103489621555196 1805 1657.27272727273 1643 0.000135449060312254 120 1.76309077669793 1.76309077669793 1 13.2851050930571 1801 2059 1143 1643 1900 4202 2397 120 945 755 1265 1417 M15749 GO_LIPID_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_LOCALIZATION.html Any process in which a lipid is transported to, or maintained in, a specific location. 118/373 Gene Ontology BP GO:0010876 0.00084603460853056 0.00720759392184843 1105 1570.63636363636 1644 7.6941830534136e-05 351 1.59310789827604 1.67061792503306 1 12.9543134479469 1103 351 363 900 1785 3134 1644 1981 2501 1459 2056 1418 M16443 GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. 22/48 Gene Ontology BP GO:0035924 0.161385165508919 0.258740097879113 610 1711.90909090909 1645 0.0158730158730159 608 2.46711003640163 2.46711003640163 1 5.49837877717 608 1645 1809 1058 3633 1977 1085 1246 1292 2373 2105 1419 M12080 GO_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. 49/163 Gene Ontology BP GO:0042752 0.0540594022276753 0.129732455206741 2140 1750.18181818182 1647 0.0050395771374934 793 0.980752082384849 1.14320510426033 1 3.30191793556797 2138 940 793 2222 1151 1647 1121 1005 3385 2313 2537 1420 M13920 GO_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that modulates the frequency, rate or extent of protein acetylation. 42/101 Gene Ontology BP GO:1901983 0.034727942506417 0.095409371039819 1470 2107.18181818182 1647 0.00320805158090104 293 0.345891122472732 0.360749071326895 1 1.33974120017886 1467 3590 2360 3865 1647 804 293 664 3801 3876 812 1421 M12647 GO_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BACTERIUM.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. 277/948 Gene Ontology BP GO:0009617 3.67335946486095e-11 5.88117517081013e-09 1720 1936.09090909091 1648 3.3394176953839e-12 29 1.46079345773198 1.51140514612353 1 45.6377430670999 1720 1137 29 1111 1648 4470 2293 3014 1571 810 3494 1422 M16054 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the rate of production of a cytokine. 119/317 Gene Ontology BP GO:0001818 0.00433603550479641 0.0227482631059545 1170 1925.81818181818 1648 0.00039496410564785 482 1.13699510987996 1.19403887425183 1 7.09115653094886 1168 1308 482 1736 4463 3212 1648 1479 2103 1466 2119 1423 M10477 GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of ERBB signaling pathway. 53/115 Gene Ontology BP GO:1901184 0.0339500082494908 0.0937714980977904 1445 1999.27272727273 1650 0.00313504769862071 569 1.34573111362072 1.77354055842398 1 5.25083902934619 1442 4251 1658 4053 2561 1529 652 569 2777 1650 850 1424 M16000 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 292/975 Gene Ontology BP GO:0050778 0.0554751304206982 0.132223321634138 1460 1911.72727272727 1650 0.00517504140823397 798 1.39356995735349 1.48571120587718 1 4.64806986752856 1457 2610 798 2164 1650 3610 1509 1498 1227 1825 2681 1425 M10535 GO_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COCAINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. 28/70 Gene Ontology BP GO:0042220 0.0197217912023291 0.0654994825124564 1200 1884.54545454545 1651 0.00180916703328249 439 0.441387499700567 0.497976769837237 1 1.98331503104457 1200 633 2050 1651 1496 2994 2553 439 3281 3043 1390 1426 M11958 GO_MITOTIC_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_ARREST.html The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M). 11/18 Gene Ontology BP GO:0071850 9.46506923106361e-06 0.000227701121449888 4230 2025.27272727273 1651 8.60464541174178e-07 6 1.38604142955966 1.38604142955966 1 19.1645699764679 4229 296 1651 255 6 4033 2426 4040 199 771 4372 1427 M12214 GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. 10/23 Gene Ontology BP GO:0034104 1.38115703579934e-05 0.000312815225230064 3175 1998.63636363636 1651 1.25560518796437e-06 8 1.61876605132699 1.61876605132699 1 21.5349401449135 3171 827 868 714 8 4060 3386 3667 1651 722 2911 1428 M14126 GO_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_METABOLIC_PROCESS.html The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 102/392 Gene Ontology BP GO:0008202 0.0438590788145919 0.112051654492429 3070 1763.72727272727 1653 0.00406896919252387 601 1.22547602450691 -0.973561863814822 -1 4.42182460015633 1947 601 1051 899 907 3347 1832 3066 1031 1653 3067 1429 M15288 GO_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_BEHAVIOR.html The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. 87/330 Gene Ontology BP GO:0007626 0.0112085711482943 0.0441101679359682 1905 1733.36363636364 1653 0.00102418975462849 421 1.45026012590137 1.6201432922922 1 7.46174247704134 1905 2198 581 1244 1653 4001 2899 421 1043 649 2473 1430 M11998 GO_FOREBRAIN_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_CELL_MIGRATION.html The orderly movement of a cell from one site to another at least one of which is located in the forebrain. 23/93 Gene Ontology BP GO:0021885 0.0968729137257371 0.177919675011312 1485 1902.72727272727 1654 0.00922014029007006 710 1.31181445190434 1.31181445190434 1 3.73345731560261 1484 2257 1498 2163 2974 3023 2821 876 1470 710 1654 1431 M12668 GO_REGULATION_OF_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of heart morphogenesis. 12/47 Gene Ontology BP GO:2000826 0.0244743153379935 0.0753542746116073 3790 1950 1655 0.00225008199134631 101 1.07330692776297 -1.10623893511792 -1 4.5747692423273 3790 128 1655 155 660 3105 4379 4479 101 381 2617 1432 M15054 GO_PARAXIAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARAXIAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. 9/23 Gene Ontology BP GO:0048339 0.00557535445343601 0.0270212638072061 2290 1795.45454545455 1657 0.000558939210638434 278 1.42779691826152 -1.38975139692581 -1 8.49965400164389 2289 436 4341 697 278 1916 3423 3262 1657 680 771 1433 M10378 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 7/17 Gene Ontology BP GO:0090141 0.0956601512363433 0.176040460638265 485 1742.27272727273 1658 0.0100046224778458 403 0.334893750198213 -0.334893750198213 -1 0.958978254977359 481 2471 3575 2685 1658 403 765 1261 2263 3012 591 1434 M13973 GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 17/45 Gene Ontology BP GO:0061036 0.00119977748672266 0.0088703294121868 4070 2328.45454545455 1659 0.000109130208131906 104 1.29170622119269 1.25902449594832 1 10.0614619821608 4070 1111 1088 1080 104 4558 3268 3648 1659 532 4495 1435 M15900 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein. 4/20 Gene Ontology BP GO:0042510 0.00953030093661913 0.0392592104060817 1580 2068.54545454545 1659 0.000957142133758649 395 0.726989375002286 -0.190506714926829 -1 3.88006200761588 1576 2037 4476 2334 395 1659 562 1228 2609 4374 1504 1436 M12796 GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. 54/121 Gene Ontology BP GO:0009063 0.01112218072694 0.0439679465142559 3175 1907.72727272727 1660 0.00101625550355557 415 1.06319686140282 -0.914905382662472 -1 5.4759210560651 3173 868 925 1385 415 1431 3286 2933 2795 1660 2114 1437 M15384 GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. 12/37 Gene Ontology BP GO:0099601 0.0614677594106027 0.141709283336511 3345 2106.45454545455 1660 0.00575049951012038 385 1.43185585027567 -1.3811115522525 -1 4.61222436746222 3344 1118 1154 413 1071 3743 4274 4348 1661 385 1660 1438 M12748 GO_REGULATION_OF_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 179/457 Gene Ontology BP GO:0090087 0.0459377070898682 0.115860574033061 1200 1650.09090909091 1661 0.00426599405974336 665 1.1773689143761 1.41761701975203 1 4.18336240930678 1199 2045 1024 1882 1661 2486 1569 665 2302 2131 1187 1439 M14213 GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 54/160 Gene Ontology BP GO:0042035 0.104661745741284 0.18900991267086 3055 2299.90909090909 1661 0.01 51 1.14450503898552 1.13871921590628 1 3.14320517473993 3053 51 1361 566 1572 4260 3593 3539 1480 1661 4163 1440 M15186 GO_ENDOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_SYSTEM_DEVELOPMENT.html Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. 54/165 Gene Ontology BP GO:0035270 0.0180929614489614 0.0617688382408293 4585 2171.72727272727 1662 0.00165849957935018 560 1.41492070465498 -1.38945983718384 -1 6.49454080024298 4583 1011 643 1508 560 2470 3864 3951 1133 1662 2504 1441 M10361 GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. 9/20 Gene Ontology BP GO:0002861 0.00252885046600838 0.0154900431578851 2190 2009.81818181818 1663 0.000253173287166186 164 1.11882204112119 1.11882204112119 1 7.68659840869672 2187 1663 3573 1465 763 4421 3330 164 747 1581 2214 1442 M15452 GO_MONOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 103/276 Gene Ontology BP GO:0005996 0.0271825946553468 0.0805416636788611 2930 2065.18181818182 1663 0.00250221658071277 699 1.18163928778114 1.25136439945956 1 4.90683324351664 2926 1266 1220 896 699 2669 3768 1730 1494 1663 4386 1443 M16386 GO_SIGNAL_PEPTIDE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_PEPTIDE_PROCESSING.html The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. 13/30 Gene Ontology BP GO:0006465 0.0778016577553352 0.158445571591463 4380 1911.45454545455 1663 0.00733613611028835 49 1.83926745395347 1.98491910416244 1 5.58608045008384 4380 556 1663 463 1190 2401 3570 2367 49 410 3977 1444 M12385 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE.html A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 6/15 Gene Ontology BP GO:0033540 0.0241512138049644 0.0749056652950379 1655 2013 1664 0.00244177767408715 653 0.50491279453589 -0.50491279453589 -1 2.15706606833292 1655 3119 3900 2521 681 679 1664 781 3016 3474 653 1445 M16074 GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. 103/259 Gene Ontology BP GO:0030178 0.0775986140995435 0.158445571591463 3240 2045.63636363636 1664 0.00731626916230871 212 1.37550011052951 1.59260984224419 1 4.17756224627316 3240 212 1208 1033 1187 2119 4546 1038 1764 1664 4491 1446 M13835 GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. 34/76 Gene Ontology BP GO:0030433 0.00435060368013898 0.0227732276064096 1005 2002.18181818182 1665 0.00039629373627235 54 0.239829359837824 -0.278931269087905 -1 1.49532259963276 1003 2920 3297 3013 852 54 901 1665 4198 3847 274 1447 M15469 GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of skeletal muscle contraction. 11/25 Gene Ontology BP GO:0014819 0.176775690461713 0.278415716015513 1950 2312.81818181818 1665 0.017528784750354 858 0.498706295576299 -0.611910924887146 -1 1.05119829014555 1946 3641 1397 3890 1641 858 1665 1305 3276 4285 1537 1448 M12328 GO_OVARIAN_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVARIAN_FOLLICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. 31/77 Gene Ontology BP GO:0001541 0.076973585792391 0.158445571591463 3860 2158.63636363636 1666 0.00725513777785891 949 1.81716829080375 -1.38975139692581 -1 5.51896258586435 3856 949 1509 1286 1183 1952 3552 3430 1387 1666 2975 1449 M12819 GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 118/257 Gene Ontology BP GO:0051495 0.0839184282471183 0.158445571591463 1870 1695.81818181818 1666 0.00793650793650794 707 1.19435717704519 1.256771596893 1 3.62740897885976 1868 763 1302 707 1679 3542 1666 1776 1167 1458 2726 1450 M14150 GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The regulation of blood pressure mediated by detection of stimuli and a neurological response. 6/22 Gene Ontology BP GO:0001976 0.107927662709418 0.194152707462157 1415 1954.63636363636 1669 0.0113558355803553 815 0.636870605211035 -0.724510478166147 -1 1.72088131946133 1412 1669 4192 2053 2225 815 833 960 2322 3931 1089 1451 M13745 GO_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_POLARITY.html The maintenance of established anisotropic intracellular organization or cell growth patterns. 3/17 Gene Ontology BP GO:0030011 0.0011158520318466 0.00836979157328558 1545 2047.09090909091 1670 0.000111641273473005 49 0.433011789689193 -0.433011789689193 -1 3.41431127220119 1541 1670 4126 2774 3893 203 49 1396 2810 3825 231 1452 M13873 GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is regionalized in the dorsoventral axis. 5/25 Gene Ontology BP GO:0021904 0.0770780095314453 0.158445571591463 3500 2250.27272727273 1670 0.00798897370469108 995 1.49234186417521 1.49234186417521 1 4.53242495773554 3497 1133 4150 1298 1227 1851 995 4065 1670 1200 3667 1453 M10054 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. 32/82 Gene Ontology BP GO:0030858 0.000478393613124908 0.00471899098907953 1830 1564.09090909091 1673 4.34997883892826e-05 66 1.70886052541589 -1.44099819578299 -1 15.0886965428362 1827 1729 858 1673 3786 2152 2132 66 762 972 1248 1454 M14267 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. 9/21 Gene Ontology BP GO:0071636 0.147859119791321 0.249186894080256 1645 2056.90909090909 1673 0.0158730158730159 1187 0.53213215065926 0.760867807203872 1 1.21894994421637 1641 1187 4215 1472 2192 1759 1236 1673 1365 3964 1922 1455 M11723 GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS.html Any process that modulates levels of neurotransmitter. 88/285 Gene Ontology BP GO:0001505 0.0839184282471183 0.158445571591463 4475 2197.36363636364 1674 0.00793650793650794 700 1.58876809015353 1.69943746909448 1 4.82528321207594 4474 700 1100 1674 2178 1189 3689 3565 1175 1344 3083 1456 M12558 GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids with a chain length of less than C6. 10/26 Gene Ontology BP GO:0046459 0.195273483868097 0.302016917255021 1455 1660.54545454545 1674 0.0195564951384904 424 0.940767540772448 -0.940767540772448 -1 1.85680707414843 1455 424 2230 767 2054 597 1674 2810 1932 3522 801 1457 M16893 GO_EMBRYO_IMPLANTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_IMPLANTATION.html Attachment of the blastocyst to the uterine lining. 22/60 Gene Ontology BP GO:0007566 0.0794100470805 0.158445571591463 1855 1789.72727272727 1675 0.00749365074533194 225 1.11969405921381 1.22741264087172 1 3.40064794855017 1851 638 859 453 1337 3935 1675 3485 225 2374 2855 1458 M14343 GO_CELLULAR_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 32/117 Gene Ontology BP GO:0071398 0.011805985256234 0.0457555839271239 1240 1524.63636363636 1677 0.00107907459025188 76 1.35593454827845 1.35593454827845 1 6.89456385623466 1236 76 738 1370 435 2263 1677 1906 2454 2579 2037 1459 M14890 GO_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTHENED_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. 34/88 Gene Ontology BP GO:0007224 0.161385165508919 0.258740097879113 2780 1949.45454545455 1677 0.0158730158730159 258 1.15907970910085 -0.9220180766526 -1 2.58320836091787 2779 258 2232 905 4423 843 2243 3578 1474 1032 1677 1460 M11330 GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. 10/25 Gene Ontology BP GO:1902931 0.104661745741284 0.18900991267086 2195 1805.54545454545 1679 0.01 136 1.14287684912524 -1.38916827744188 -1 3.13873360439269 2191 136 1790 776 4222 844 1063 4164 1288 1679 1708 1461 M14792 GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neuron migration. 9/24 Gene Ontology BP GO:2001224 0.0105857827349989 0.0421524779061748 1045 2228.90909090909 1679 0.00106365498850558 165 1.1712352121029 1.1712352121029 1 6.11378155267805 1044 3895 4292 3284 2864 1309 165 1679 3468 1616 902 1462 M16394 GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. 11/24 Gene Ontology BP GO:0030826 0.0674787821719611 0.151376816050765 4090 2140.54545454545 1681 0.00633108948025836 781 1.29245240179828 -1.29245240179828 -1 4.02257544480262 4089 826 1345 862 1110 2323 4367 4439 1723 781 1681 1463 M16470 GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 20/42 Gene Ontology BP GO:0090314 0.00222658020916124 0.0141036997423406 3450 1811.18181818182 1681 0.000202621535353633 150 1.24907563888908 1.36658472553921 1 8.77453756743343 3450 541 2484 1090 150 1285 2998 3603 1681 641 2000 1464 M10999 GO_PEROXISOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 25/36 Gene Ontology BP GO:0007031 0.124818345667031 0.218691161861141 4325 2377.54545454545 1683 0.0120471907506667 573 0.23042094976188 -0.206658009074079 -1 0.577409822849675 1683 4325 3350 4324 1430 573 1241 1475 3451 3134 1167 1465 M11700 GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. 10/33 Gene Ontology BP GO:0002675 0.00811944211076804 0.035265266342653 865 1567.09090909091 1683 0.000740869447891851 279 1.11882204112119 1.11882204112119 1 6.16921746810649 861 3068 1016 2263 2046 1946 1729 279 1135 1683 1212 1466 M15741 GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. 85/214 Gene Ontology BP GO:0060759 0.124534184591718 0.21827565838405 2115 1948.54545454545 1683 0.0120180335510277 1252 1.30132427641554 1.40134128303427 1 3.26505675993657 2111 1570 1683 1259 1429 3900 1843 1485 2042 1252 2860 1467 M11467 GO_REGULATION_OF_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXIT_FROM_MITOSIS.html Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. 16/27 Gene Ontology BP GO:0007096 0.0102477757106693 0.0413524357861842 1150 1625.36363636364 1684 0.000935984027431713 176 0.382239966494278 -0.3903589661178 -1 2.0073455742989 1146 1699 2293 1684 2279 193 973 370 3805 3261 176 1468 M11851 GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). 53/127 Gene Ontology BP GO:0043648 0.0019347699071781 0.0126156182485728 2185 1639 1684 0.000176043047344566 141 0.937302520264247 -0.996842208398223 -1 6.75667293620023 2183 1684 1628 1892 141 710 2879 2402 1148 2381 981 1469 M12215 GO_MEMBRANE_TUBULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_TUBULATION.html A modification in a plasma membrane resulting in formation of a tubular invagination. 8/14 Gene Ontology BP GO:0097320 0.0944579044628667 0.174519717636725 2390 1967.81818181818 1685 0.00987308925899157 912 1.69748649654937 1.69748649654937 1 4.8850818883704 2387 979 3870 1661 2552 2719 1578 912 1685 1512 1791 1470 M10095 GO_REGULATION_OF_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_BURST.html Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 6/20 Gene Ontology BP GO:0060263 0.0260290666933687 0.078834283533797 1310 1848.18181818182 1686 0.0026339070026027 527 1.14672566625037 1.14672566625037 1 4.80235685489612 1310 2403 3531 2131 2919 1686 1584 527 1957 1300 982 1471 M13534 GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. 5/22 Gene Ontology BP GO:0021514 0.200844424616524 0.30837323528258 1190 2152.36363636364 1686 0.0221705043329161 848 0.470353370550894 0.522251085138121 1 0.912194017155193 1190 1818 4093 1686 2361 1302 1284 1586 3740 3768 848 1472 M12236 GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION.html A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. 10/31 Gene Ontology BP GO:0072378 0.000939742655819996 0.007791473483879 1595 1856.36363636364 1687 8.54676647745386e-05 88 1.15313456995808 1.15313456995808 1 9.22860789423578 1591 1401 1221 1948 2271 3128 3583 88 1385 1687 2117 1473 M14822 GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY.html The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 13/26 Gene Ontology BP GO:0035058 0.0267658355173923 0.0800217477831632 1865 1915.36363636364 1689 0.0024633757510682 692 0.493393016758395 -0.493393016758395 -1 2.05411375389973 1865 1039 3044 1517 692 1100 2420 2229 1689 4106 1368 1474 M13263 GO_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 8/21 Gene Ontology BP GO:0090140 0.103951383516044 0.188552545578538 360 1774.63636363636 1691 0.0109160436304337 357 0.348050819740362 -0.348050819740362 -1 0.957257553651395 357 2275 4039 2653 1691 406 632 1282 1857 3687 642 1475 M16599 GO_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 114/278 Gene Ontology BP GO:0030098 0.0839184282471183 0.158445571591463 2090 1650.90909090909 1692 0.00793650793650794 991 1.39057270421268 1.44218470975861 1 4.22333955871747 1144 2090 1526 2138 1692 2089 1719 2108 1097 991 1566 1476 M11632 GO_CARTILAGE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_MORPHOGENESIS.html The process in which the anatomical structures of cartilage are generated and organized. 8/20 Gene Ontology BP GO:0060536 0.0117198299938317 0.0455357076664105 410 1745.63636363636 1693 0.00117821021993978 176 0.896585420808603 0.896585420808603 1 4.56601634736915 409 1807 3778 2567 925 470 176 1693 3500 3302 575 1477 M12850 GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. 10/18 Gene Ontology BP GO:0035024 0.258007399229327 0.373070182068442 595 2058.45454545455 1693 0.026764049245818 592 1.19045135446987 1.19045135446987 1 1.93497404054874 592 3436 1565 2549 2756 1428 1178 1810 4066 1693 1570 1478 M13724 GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of heart contraction. 22/57 Gene Ontology BP GO:0045823 0.00485105141129066 0.0246440356923155 1695 1717 1693 0.000441980111905912 356 1.23564681817399 1.25962065082781 1 7.54337075875849 1693 1329 495 1003 2841 2777 2399 3209 1775 356 1010 1479 M10819 GO_ACTIN_MYOSIN_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MYOSIN_FILAMENT_SLIDING.html The sliding movement of actin thin filaments and myosin thick filaments past each other. 26/58 Gene Ontology BP GO:0033275 0.000104780567400749 0.00150618010663058 510 1532.36363636364 1694 9.52595983392851e-06 255 2.59443856790082 -2.59443856790082 -1 27.7924335094341 508 2630 255 2688 1694 576 1000 2156 2181 1447 1721 1480 M16730 GO_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. 188/476 Gene Ontology BP GO:0048589 0.0839184282471183 0.158445571591463 1695 1860.81818181818 1694 0.00793650793650794 831 1.54123919564149 1.5976028876124 1 4.68093214019375 1694 2044 1115 1014 2070 4086 2719 1297 923 831 2676 1481 M13937 GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. 20/66 Gene Ontology BP GO:0002228 0.0284977182590584 0.0832692925593505 1725 1816.45454545455 1695 0.00262488181998795 717 0.739899500737183 0.739899500737183 1 3.03185688353155 1722 1695 2929 1498 717 2419 838 1903 1202 3880 1178 1482 M14866 GO_MUSCLE_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FILAMENT_SLIDING.html The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. 26/58 Gene Ontology BP GO:0030049 0.000104780567400749 0.00150618010663058 510 1533.63636363636 1695 9.52595983392851e-06 256 2.59443856790082 -2.59443856790082 -1 27.7924335094341 509 2631 256 2689 1695 577 1001 2154 2182 1454 1722 1483 M15848 GO_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 263/825 Gene Ontology BP GO:0043269 0.00350271081809914 0.0194767500939333 1700 2018.81818181818 1697 0.000318936371912673 465 1.49029810006154 1.69111511623592 1 9.67607598323136 1697 2151 465 1492 1996 4469 2930 1545 948 1105 3409 1484 M10333 GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. 21/51 Gene Ontology BP GO:0031109 0.142086168699961 0.243176155059952 1235 2105.72727272727 1699 0.0138353642419191 469 0.583871951991638 -0.583871951991638 -1 1.36097171348257 1233 3843 2144 3996 1699 469 1022 1247 3504 3002 1004 1485 M13605 GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 10/20 Gene Ontology BP GO:0036109 9.26833853956337e-05 0.00135750460060545 4200 2076 1699 8.42611729698388e-06 24 0.893227070942494 -0.50491279453589 -1 9.72156054876075 4198 1044 2734 770 24 4358 1568 2233 110 1699 4098 1486 M10482 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. 9/23 Gene Ontology BP GO:0045603 0.435369722646862 0.553965914565464 1335 2088.54545454545 1700 0.0555555555555556 1332 1.54796415353554 -1.54796415353554 -1 1.50724623947561 1332 1344 3596 1700 3209 1671 1668 1781 2506 1584 2583 1487 M12806 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. 15/43 Gene Ontology BP GO:0051769 0.0653623044709912 0.147677459687987 2545 1822.45454545455 1700 0.00612627702330207 837 1.19317718245127 1.19317718245127 1 3.76226125744913 2545 1700 2139 1685 1095 2938 2850 837 1729 961 1568 1488 M11525 GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. 16/41 Gene Ontology BP GO:1900026 0.0281406996921191 0.0824336079940119 2395 1826.18181818182 1702 0.00259156678393732 383 1.6722414479866 1.6722414479866 1 6.88008342859174 2392 1490 1702 951 3790 2783 2145 525 383 999 2928 1489 M10717 GO_NEGATIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. 18/49 Gene Ontology BP GO:0014014 0.0839184282471183 0.158445571591463 1315 1770.45454545455 1703 0.00793650793650794 809 0.849254971022537 0.849254971022537 1 2.57929132622512 1311 809 2806 1266 2282 2230 1038 1703 941 3080 2009 1490 M11713 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 75/200 Gene Ontology BP GO:0034764 0.0200099294306849 0.0659614325140451 4255 2143.63636363636 1704 0.0018358436320447 585 1.41454484137189 -1.10189111717827 -1 6.3396774556993 4252 1923 1152 1566 585 1704 3924 2225 980 1557 3712 1491 M12834 GO_FEAR_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEAR_RESPONSE.html The response of an organism to a perceived external threat. 10/47 Gene Ontology BP GO:0042596 0.011544843304005 0.044968714312496 2755 1921.72727272727 1706 0.00105507959371399 90 1.98294428544816 1.98294428544816 1 10.1394454600023 2755 3547 1518 1706 3159 3541 2417 341 90 725 1340 1492 M10528 GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/20 Gene Ontology BP GO:0010766 0.0209768111528693 0.0680135015242823 2140 1851.18181818182 1707 0.00211774944502663 483 1.38933387508025 1.38933387508025 1 6.15652085764397 2140 1454 3599 1683 628 3030 2192 483 1707 1492 1955 1493 M15238 GO_COENZYME_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 10/22 Gene Ontology BP GO:0009109 0.0258564703367441 0.0784650926624202 2595 1631.63636363636 1707 0.00237867782847628 252 0.964916235402726 -0.810865129405406 -1 4.0484264306483 2591 2030 2709 1859 1591 291 252 3180 768 1707 970 1494 M10971 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 16/75 Gene Ontology BP GO:0071379 0.0550863791245934 0.131566902405086 1710 1922.09090909091 1709 0.00513782527874506 281 0.577655293903853 0.653503837183849 1 1.93143278593486 1709 281 950 1447 1005 2509 2564 1690 3532 3126 2330 1495 M16536 GO_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 55/235 Gene Ontology BP GO:0042445 0.0839184282471183 0.158445571591463 1450 1763.45454545455 1709 0.00793650793650794 869 1.1657355142316 -0.947040535988886 -1 3.54048148457213 1449 2095 1709 2034 1665 1628 910 3230 869 1738 2071 1496 M15428 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter. 10/20 Gene Ontology BP GO:0045943 0.0329839678487745 0.0924152744466946 1670 1972.27272727273 1710 0.00304446567752717 395 1.21455215107271 1.21455215107271 1 4.76816800669655 1666 2604 3043 3119 2766 3487 1457 565 395 1710 883 1497 M16928 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. 844/2274 Gene Ontology BP GO:0006357 0.0280626100161961 0.0822567539805545 1420 2125.72727272727 1711 0.00284234189490805 742 1.26376826241256 1.34259748552669 1 5.20398139032857 1418 2951 4638 2580 742 3380 1292 1161 2288 1222 1711 1498 M15459 GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. 6/18 Gene Ontology BP GO:0014741 0.0689513545408043 0.153766157124378 730 2098.81818181818 1712 0.00711891485103123 427 0.900416075626817 0.900416075626817 1 2.77917177356184 728 1712 4410 2039 3057 888 427 1399 3214 4279 934 1499 M15580 GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. 23/53 Gene Ontology BP GO:0000096 0.085828674880445 0.160768496205839 960 1932.36363636364 1712 0.00812474887086803 953 0.686007751272719 -0.686007751272719 -1 2.0670302340416 959 2297 2193 2470 1244 953 1504 1712 2389 4311 1224 1500 M16100 GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. 54/119 Gene Ontology BP GO:0032273 0.0839184282471183 0.158445571591463 2005 1897.45454545455 1712 0.00793650793650794 864 0.885892611905994 -0.625059557561618 -1 2.69056432735545 2001 1012 1705 1712 2519 3214 1166 864 1176 2767 2736 1501 M15581 GO_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 8/25 Gene Ontology BP GO:0000305 0.00062098290637077 0.0058603562251599 3250 2020.81818181818 1713 6.21156503545048e-05 71 1.09801440639219 -1.03069309216194 -1 9.3030262011471 3250 661 4428 877 71 1713 1041 3765 2204 625 3594 1502 M11014 GO_ENDOSOME_TO_LYSOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_TO_LYSOSOME_TRANSPORT.html The directed movement of substances from endosomes to lysosomes. 27/55 Gene Ontology BP GO:0008333 0.197568509268519 0.304956977571055 3145 1918.63636363636 1714 0.0198110214720084 625 0.858982002181133 0.858982002181133 1 1.68166758411739 1817 719 3142 1136 1714 625 1381 2425 3293 3141 1712 1503 M10774 GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 20/30 Gene Ontology BP GO:0033158 0.0160398701751094 0.0568362688050061 1605 1974 1715 0.00146891111254564 512 1.25050554594971 1.25050554594971 1 5.9114334047736 1605 3915 1866 3065 512 2346 1715 653 3259 1143 1635 1504 M13060 GO_SUBSTANTIA_NIGRA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTANTIA_NIGRA_DEVELOPMENT.html The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). 44/111 Gene Ontology BP GO:0021762 0.0284164716714041 0.0831365330625894 2070 1559.18181818182 1716 0.00261729935103666 713 1.12567747216445 1.41146665776247 1 4.61560496093639 2069 1775 1023 1632 713 854 2383 1767 1050 2169 1716 1505 M14041 GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. 13/47 Gene Ontology BP GO:1903020 0.207899338852682 0.316484141079674 1520 1938.54545454545 1717 0.0209650042957625 721 0.546086881640239 0.555879599741466 1 1.03569807592983 1518 2646 1667 2488 1853 1717 721 1544 1962 3907 1301 1506 M15297 GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 224/577 Gene Ontology BP GO:0051090 0.210898925462635 0.319896671324082 1795 1699.27272727273 1717 0.0213026298235895 480 1.34659725976633 1.43561623070765 1 2.53012295796108 1794 480 1406 754 1753 4034 1446 1717 1830 1175 2303 1507 M15151 GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 12/23 Gene Ontology BP GO:0042776 0.170399903810154 0.271226175313865 790 2033.54545454545 1718 0.0168394682600064 748 0.217582180216252 -0.233097341855247 -1 0.468014760494142 790 1494 3424 2419 1605 748 1718 1749 3166 4193 1063 1508 M15705 GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. 14/55 Gene Ontology BP GO:0042462 0.161385165508919 0.258740097879113 2260 2197 1718 0.0158730158730159 922 1.19951281013891 1.40369885952815 1 2.67332047645781 2258 1237 1706 1363 4409 3678 2620 1718 1283 922 2973 1509 M12564 GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS.html The cellular component assembly that is part of the initial shaping of the component during its developmental progression. 147/381 Gene Ontology BP GO:0010927 0.00167646564590993 0.0113632554656347 855 1494.27272727273 1719 0.000152522229757136 25 1.31140684279357 -1.00604341992337 -1 9.67947951879735 855 1568 1799 2176 2216 25 1021 1719 1888 2674 496 1510 M11086 GO_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. 121/310 Gene Ontology BP GO:0007009 0.0232181895886241 0.0728884748208125 1070 1704.45454545455 1720 0.00213335551630503 588 1.3387532139257 1.46027369488781 1 5.77960961923911 1069 2802 680 2231 2906 2322 1356 1953 1122 588 1720 1511 M15365 GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS.html Any apoptotic process that contributes to the shaping of an anatomical structure. 15/28 Gene Ontology BP GO:0060561 0.00586915288565058 0.0280643427889553 560 1728.90909090909 1720 0.000534988120338546 158 0.438424398389078 0.529758348222341 1 2.582559414029 560 2216 1720 2282 3622 559 158 243 3093 4253 312 1512 M16837 GO_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 76/200 Gene Ontology BP GO:0051592 0.0738179657395581 0.158445571591463 1680 1839.72727272727 1721 0.00694707332116195 701 1.84026618541044 1.84026618541044 1 5.58911371979936 1676 701 849 967 3760 2545 1099 1721 1815 2268 2836 1513 M10534 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS.html Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 9/17 Gene Ontology BP GO:0010561 0.00922678644829996 0.0382158514535742 1685 1939.09090909091 1724 0.00092653219415842 319 1.74485001602008 1.74485001602008 1 9.39002973689298 1682 2940 3600 2332 3290 1578 509 319 1724 1585 1771 1514 M11570 GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. 11/32 Gene Ontology BP GO:0002714 0.0656529533554237 0.148117911773194 1725 1450.72727272727 1724 0.00615437825055673 401 1.11882204112119 1.11882204112119 1 3.52231592427948 1724 1447 2000 1354 2214 1959 498 766 401 1780 1815 1515 M12823 GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 29/68 Gene Ontology BP GO:0051898 0.0514169219255542 0.125316938845327 1570 1908.18181818182 1724 0.0047872231396215 662 1.16726469809296 1.16726469809296 1 3.99648706844994 662 2924 2471 2648 979 2392 1724 1566 2560 1566 1498 1516 M14225 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. 11/32 Gene Ontology BP GO:0002891 0.0638702364460487 0.1457962182001 1725 1453 1725 0.00598214220098366 402 1.11882204112119 1.11882204112119 1 3.55145501654542 1725 1448 2001 1355 2215 1960 499 757 402 1805 1816 1517 M11938 GO_RESPONSE_TO_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METAL_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. 199/517 Gene Ontology BP GO:0010038 6.37961554513346e-08 3.48477117365349e-06 1765 1775.18181818182 1726 5.79965066375559e-09 85 1.59699452030258 1.65315304912473 1 33.0849377461946 1761 921 85 735 3223 3978 2381 1726 1124 941 2652 1518 M12539 GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. 79/222 Gene Ontology BP GO:0071346 0.00616080230221195 0.0290830863501857 1820 1879.09090909091 1726 0.000561647521682364 521 1.60289662011316 1.75618442454155 1 9.34771787620931 1819 2482 521 2399 1198 3637 1447 1240 1067 1726 3134 1519 M14546 GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of activated T cell proliferation. 9/28 Gene Ontology BP GO:0042104 0.0163654823841594 0.057520768137511 1705 2168 1727 0.0016487269651813 211 0.577540506323414 0.677893810012948 1 2.71877185752632 1727 1551 4250 1704 3305 1702 211 646 2728 4043 1981 1520 M10177 GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity. 14/37 Gene Ontology BP GO:1904030 0.0204105973914546 0.0668023830199863 1655 1585.36363636364 1728 0.00187295038463702 452 1.26556114324707 1.26556114324707 1 5.6455351914551 1654 1739 1728 1812 2554 2502 927 452 1791 909 1371 1521 M10872 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME.html A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. 11/33 Gene Ontology BP GO:0001977 0.0242651522520737 0.0750087229736205 520 1538.54545454545 1730 0.00223063586847913 488 1.45023161899474 1.45023161899474 1 6.19232829174223 518 2508 1730 2873 2121 622 1059 488 2437 1775 793 1522 M15100 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 13/49 Gene Ontology BP GO:0032228 0.161385165508919 0.258740097879113 2795 1912.54545454545 1730 0.0158730158730159 1013 0.743128926420273 -0.743128926420273 -1 1.6561905456738 2794 1175 2218 1289 2050 1013 1819 1458 1308 4184 1730 1523 M10140 GO_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 55/151 Gene Ontology BP GO:0016052 0.0839184282471183 0.158445571591463 1955 1754.90909090909 1731 0.00793650793650794 236 1.44502044971407 1.44502044971407 1 4.38870402817097 1954 236 1584 454 2962 4365 1751 1480 517 1731 2270 1524 M12370 GO_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_SIGNAL_TRANSDUCTION.html The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. 826/2025 Gene Ontology BP GO:0035556 0.0765897756730953 0.158445571591463 1475 1931.81818181818 1731 0.00793650793650794 645 1.28992023989791 1.38321763449703 1 3.91764570110543 1472 846 3897 854 1745 4437 1994 1731 1154 645 2475 1525 M15630 GO_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 937/2497 Gene Ontology BP GO:0051049 0.0765897756730953 0.158445571591463 2130 2222.09090909091 1731 0.00793650793650794 766 1.32336137860211 1.44794079988448 1 4.01921053375033 2130 1715 4433 1731 1506 2662 2843 1565 1196 766 3896 1526 M10648 GO_EMBRYONIC_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. 16/46 Gene Ontology BP GO:0000578 0.0561370973598677 0.133390247206687 3470 2105.90909090909 1732 0.00523844520732048 284 1.2692844111372 -1.07272638267715 -1 4.21514619340953 3470 284 1732 1330 1013 3448 3858 2529 1662 997 2842 1527 M10130 GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 22/102 Gene Ontology BP GO:0018958 0.00593136541980119 0.0281876454904165 4375 2346.27272727273 1733 0.000540674313472336 516 1.73732271769681 2.09063753046425 1 10.221225085625 4373 2527 516 1733 570 4599 4608 1129 673 693 4388 1528 M12662 GO_NEURAL_NUCLEUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_NUCLEUS_DEVELOPMENT.html The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. 55/153 Gene Ontology BP GO:0048857 0.0217293469306838 0.0696268859897619 4185 2325.45454545455 1733 0.0019951802359187 668 1.40540440029376 1.68917283340221 1 6.17341691037142 4185 1273 668 1130 1037 2423 4343 3899 774 1733 4115 1529 M13295 GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 25/69 Gene Ontology BP GO:0060393 0.0037197733901348 0.0203666366160329 4605 2222.90909090909 1733 0.000338734339442835 211 1.43433414636607 -1.79325614046967 -1 9.20707959992951 4603 1733 694 1235 211 3945 3641 4016 1326 422 2626 1530 M10345 GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. 26/73 Gene Ontology BP GO:0046470 0.0839184282471183 0.158445571591463 4040 2441.18181818182 1734 0.00793650793650794 300 1.28812218568679 -1.02192717514728 -1 3.91218479031967 4037 1105 1734 718 1521 4388 3194 4127 300 1446 4283 1531 M14671 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition. 63/135 Gene Ontology BP GO:1902807 0.0760013300061666 0.158445571591463 1475 1992.18181818182 1734 0.00716012029430352 853 1.41101719820346 1.42798520168239 1 4.28543199011016 1734 3706 2213 2376 1173 3903 2075 1471 937 853 1473 1532 M13214 GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS.html The process in which the right cardiac ventricle is generated and organized. 11/27 Gene Ontology BP GO:0003215 0.066168148783362 0.148846276550945 3595 2235 1736 0.00620420917000352 565 1.70820157422404 1.70820157422404 1 5.36400825484148 3592 565 1209 1398 1102 3790 955 4173 1736 1797 4268 1533 M15202 GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. 26/58 Gene Ontology BP GO:1901862 0.154120660620938 0.25758899469511 3165 1975.18181818182 1738 0.0151010503078994 634 0.900416075626817 0.900416075626817 1 2.0133503953276 3165 634 2005 882 1553 1135 2329 1086 2992 4208 1738 1534 M14239 GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. 94/300 Gene Ontology BP GO:0051480 0.000127227777952648 0.00173740756774749 740 1647 1739 1.15668305666931e-05 266 1.50359598642592 1.50359598642592 1 15.7529878138893 737 2478 266 2160 1559 2020 1631 1739 1603 2091 1833 1535 M11973 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. 72/218 Gene Ontology BP GO:0070665 0.0318773358516745 0.0900282666419249 2015 1789.63636363636 1740 0.00294080194304021 723 1.1727601076159 1.20326255848529 1 4.65468996208741 2011 1086 723 957 1720 3058 1740 2008 1198 2176 3009 1536 M10586 GO_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAPPING.html A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. 15/30 Gene Ontology BP GO:0016233 0.209365044928614 0.318336369415748 1015 1792.09090909091 1746 0.0211298348055905 1013 0.492891805032817 -0.613388682618438 -1 0.930067773448387 1013 1330 2347 1923 1746 1129 1821 1225 2721 3054 1404 1537 M13598 GO_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INTERNALIZATION.html A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. 23/81 Gene Ontology BP GO:0031623 0.185003388262201 0.288923892264178 4595 2411.54545454545 1746 0.0184255285574888 802 0.641577416624509 -0.650112755713168 -1 1.31316563035378 4592 802 1719 1524 1672 4178 1985 1223 1746 3783 3303 1538 M14994 GO_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_ACTIVATION.html Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 19/56 Gene Ontology BP GO:0010543 0.00126256194212557 0.00921709920957392 750 1629.36363636364 1746 0.000114844281704892 391 1.66304601929138 1.66304601929138 1 12.8487977368829 748 1968 391 1746 2915 2003 1274 873 2243 2248 1514 1539 M11448 GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. 28/68 Gene Ontology BP GO:0003254 0.141147732357827 0.241744612266927 1025 1752.27272727273 1749 0.013737347096677 574 2.24458518468169 2.24458518468169 1 5.25384513478854 1022 2207 1250 2450 3022 1749 574 1427 2022 2518 1034 1540 M12161 GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 2/10 Gene Ontology BP GO:0046133 0.159581654698655 0.258740097879113 1710 2194.4 1749.5 0.0191318927140428 791 1.0296882537552 -1.0296882537552 -1 2.29483726212398 1707 2368 3860 NA 1792 1090 896 4534 4057 849 791 1541 M10326 GO_NEURON_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_RECOGNITION.html The process in which a neuronal cell in a multicellular organism interprets its surroundings. 17/63 Gene Ontology BP GO:0008038 0.0116507197896344 0.045305102163545 1400 2059.18181818182 1750 0.00106480734703928 433 1.31394404283802 1.31394404283802 1 6.70248467416302 1398 2969 1750 3446 433 2541 1453 1709 3160 2139 1653 1542 M10578 GO_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LOCALIZATION.html Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. 150/339 Gene Ontology BP GO:0051648 0.0239928490083901 0.0747141501984944 2740 1845 1750 0.00220532521291542 237 1.12336306626047 1.24836586100728 1 4.80392276176959 2740 487 2698 1750 645 237 2019 4401 1531 2480 1307 1543 M13056 GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. 6/38 Gene Ontology BP GO:0071875 0.00580752355078534 0.027826967849635 1530 2129.27272727273 1751 0.000582275690889935 255 0.858982002181133 0.858982002181133 1 5.07190178806879 1529 1751 4001 3035 1175 2762 1655 255 2260 3638 1361 1544 M15407 GO_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 479/1446 Gene Ontology BP GO:0009607 7.04012580584237e-09 5.27214582524615e-07 2040 1915.54545454545 1755 6.40011438942835e-10 62 1.39709728511427 1.4917040932967 1 33.2932400258802 2037 849 62 1346 1722 3786 2187 2542 1211 1755 3574 1545 M16695 GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERAD pathway. 10/17 Gene Ontology BP GO:1904294 0.0641960357445939 0.14632410111053 1755 1932.18181818182 1755 0.00601359681104804 539 0.522536967759313 0.522536967759313 1 1.65556566423729 1755 1942 3143 2511 1086 539 950 993 2802 4567 966 1546 M10204 GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. 33/70 Gene Ontology BP GO:2000242 0.161385165508919 0.258740097879113 2255 1566.18181818182 1757 0.0158730158730159 259 1.25053204594924 1.18121393020292 1 2.7870256129442 2254 259 1820 745 2017 1322 812 2178 1441 1757 2623 1547 M14902 GO_ORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSPORT.html The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. 12/23 Gene Ontology BP GO:0015695 0.138323664153313 0.238041798615209 1350 1803.09090909091 1757 0.013442967044002 673 0.889318573677059 0.889318573677059 1 2.10423534919956 1348 1496 1757 2428 2893 995 1020 2985 2356 1883 673 1548 M15437 GO_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. 63/149 Gene Ontology BP GO:0050673 0.0271293519644949 0.0805380953779729 3110 1851.36363636364 1757 0.00249725366254484 697 1.25015218305985 1.25015218305985 1 5.19142876077899 1757 1151 835 711 697 3481 1731 3110 1800 1984 3108 1549 M10811 GO_THYMIC_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMIC_T_CELL_SELECTION.html The process of T cell selection that occurs in the thymus. 13/27 Gene Ontology BP GO:0045061 0.0290247434980496 0.0841210262555831 1190 1963.54545454545 1758 0.00267408130389731 724 1.86280643978199 1.86280643978199 1 7.60189699346111 1188 3785 2088 3137 724 1440 1758 1115 2817 1927 1620 1550 M12414 GO_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/110 Gene Ontology BP GO:0051952 0.00640912548989627 0.0297278418077806 745 1741.27272727273 1759 0.000584352119242229 256 1.32537883568007 1.66301187566353 1 7.68139024587695 745 1845 1692 998 2814 2453 2848 256 1422 1759 2322 1551 M13535 GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 203/474 Gene Ontology BP GO:0051348 0.056620007876419 0.134331474997554 1570 1936.45454545455 1760 0.00528472432540849 927 1.30883386196533 1.37758169746409 1 4.33131416205517 1566 1760 1666 1986 1020 4274 2283 927 1882 1641 2296 1552 M15189 GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. 66/198 Gene Ontology BP GO:0002761 0.0839184282471183 0.158445571591463 1550 1998.72727272727 1761 0.00793650793650794 650 1.59893050034719 1.59893050034719 1 4.85614769607925 1550 2556 1480 1578 3995 2772 1761 1262 650 2048 2334 1553 M13960 GO_ANDROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 16/68 Gene Ontology BP GO:0008209 0.00063633656829733 0.00598079086357187 3645 2068.81818181818 1765 5.78655181210249e-05 68 0.947040535988886 -0.947040535988886 -1 7.99212775204134 3644 1546 2538 1491 68 2989 1524 1765 478 2116 4598 1554 M12096 GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 58/202 Gene Ontology BP GO:0030799 8.36650482992228e-05 0.0012530865137203 1880 1893.90909090909 1766 7.60620274674798e-06 250 1.28732856369244 1.28476664463951 1 14.1806742193854 1878 1518 250 1636 1855 4542 1576 1766 2446 761 2605 1555 M16060 GO_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTOSIS.html A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. 267/858 Gene Ontology BP GO:0006897 0.00131760090987839 0.0095587828508834 1770 1950 1766 0.000119853699625482 393 1.22033308900779 1.42636768486893 1 9.35514282179889 1766 759 393 1195 1556 4299 2616 2164 1069 1833 3800 1556 M16247 GO_LIMBIC_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMBIC_SYSTEM_DEVELOPMENT.html The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. 57/180 Gene Ontology BP GO:0021761 0.0212964380299168 0.0685234662320886 3125 2160.36363636364 1768 0.00195503905898531 240 1.14392786668218 -0.832166768000818 -1 5.05497248799008 3122 240 1177 706 604 3307 4097 3318 1539 1768 3886 1557 M16821 GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS.html The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. 25/72 Gene Ontology BP GO:0048701 0.0468689054151536 0.117058810028272 1770 1749.63636363636 1768 0.00435438522543668 319 1.65563160454331 1.65563160454331 1 5.85461721458207 1768 1379 2028 1179 940 4014 2076 2147 319 794 2602 1558 M10756 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. 44/124 Gene Ontology BP GO:0051149 0.232850105696956 0.342669743502683 1775 2087.54545454545 1771 0.0238095238095238 837 1.54444415987415 1.54444415987415 1 2.72676942543962 1688 2774 1648 1838 3598 4021 1482 1771 1772 837 1534 1559 M10807 GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 11/27 Gene Ontology BP GO:0009065 0.0839184282471183 0.158445571591463 2420 1816.54545454545 1774 0.00793650793650794 816 0.907956294871668 -1.23889395501682 -1 2.75757443391194 2419 897 1599 941 1912 2603 2431 3043 816 1774 1547 1560 M15367 GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. 13/33 Gene Ontology BP GO:0006658 0.000168341143075705 0.00217113313139027 2490 1708.54545454545 1774 1.53049114274048e-05 34 1.01240235044132 -1.01240235044132 -1 10.23487808171 2489 555 1137 387 34 1938 4105 4306 109 1960 1774 1561 M11377 GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. 44/102 Gene Ontology BP GO:0008652 0.122468024863998 0.215222952098237 1775 1962.18181818182 1775 0.0118062873691878 832 1.13533089743152 -1.41448702878402 -1 2.87493520282289 1775 2998 2432 3450 2810 832 1163 978 1590 2167 1389 1562 M12446 GO_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that modulates the activity of a transporter. 105/288 Gene Ontology BP GO:0032409 0.0839184282471183 0.158445571591463 3425 2306.72727272727 1775 0.00793650793650794 891 1.38903848043637 -1.16127587962099 -1 4.21867993326455 3421 2283 1288 1140 1731 3976 3269 1775 1183 891 4417 1563 M12452 GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. 47/109 Gene Ontology BP GO:0035050 0.0824328199008217 0.158445571591463 4325 2072.72727272727 1776 0.00779035853381375 867 1.27950321373247 1.38289162926013 1 3.88600791722168 4325 1476 867 1576 1922 1220 2701 2096 1776 1441 3400 1564 M14176 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a ventricular cardiac muscle cell. 7/30 Gene Ontology BP GO:0086005 0.147859119791321 0.249186894080256 1780 2002.54545454545 1777 0.0158730158730159 556 1.51548503002097 -1.42279293755586 -1 3.47150682530677 1777 1409 4198 679 4470 1898 1043 2776 1254 556 1968 1565 M16602 GO_NEURAL_CREST_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. 40/108 Gene Ontology BP GO:0014033 0.000900411516806034 0.00755987463387056 1505 2050.36363636364 1777 8.18891133356623e-05 370 1.25851292003381 1.1928936815878 1 10.1345613981275 1505 1777 370 1182 3671 3251 1478 2712 2535 1221 2852 1566 M15494 GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 39/90 Gene Ontology BP GO:0046889 0.0466935277883205 0.116746391772306 1645 1944.27272727273 1778 0.00433773203951415 771 1.3160578356899 -1.01948926024963 -1 4.65962005593757 1643 1778 771 2297 3454 3146 1597 953 2412 2042 1294 1567 M10753 GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. 20/36 Gene Ontology BP GO:0045932 0.2108944585039 0.319896671324082 1780 2062.72727272727 1779 0.0213021261676909 1112 1.06359079531325 1.20141680851328 1 1.9983818246556 1779 1937 1112 2723 3436 3042 1642 2753 1721 1142 1403 1568 M13560 GO_BICARBONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSPORT.html The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 16/52 Gene Ontology BP GO:0015701 0.00410253826588149 0.0218190858046604 735 1760.18181818182 1779 0.000373655333760893 477 1.17612376895435 1.17612376895435 1 7.41604958472848 733 813 477 1549 3717 1779 1366 2931 2037 2114 1846 1569 M12066 GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE.html Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. 5/16 Gene Ontology BP GO:0010889 0.363419796005794 0.483483699958425 1505 2281.27272727273 1780 0.0441597535397518 948 0.650015696438098 0.739521988637395 1 0.77874103997427 1503 1460 3844 2585 3197 948 1669 1699 3004 3405 1780 1570 M11459 GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. 10/32 Gene Ontology BP GO:0065005 0.06803179783125 0.152374161760971 1460 1703.18181818182 1782 0.0063846746759037 432 0.482922960675941 0.553751486299943 1 1.49780154520549 1460 432 1856 1782 2066 2235 828 776 2933 3257 1110 1571 M12361 GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. 22/51 Gene Ontology BP GO:0050850 0.00258458757760523 0.0157300276622742 2385 2123.45454545455 1783 0.000235238998817009 162 1.05445204559117 1.15822641864813 1 7.21763550378 2385 1595 1716 1783 162 4192 3722 2196 1780 1267 2560 1572 M14533 GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 233/622 Gene Ontology BP GO:0010975 0.0268957708626299 0.0802196056244435 1255 1824.09090909091 1783 0.0024754837529586 700 1.50585984330372 1.56083823806858 1 6.26312623200192 1251 1206 700 1327 2039 4295 2190 1783 2033 1036 2205 1573 M12036 GO_ASYMMETRIC_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_CELL_DIVISION.html The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. 11/19 Gene Ontology BP GO:0008356 0.0161531923110488 0.057077071461339 1280 1690.72727272727 1784 0.00147936622943591 215 1.65735694990685 1.65735694990685 1 7.82316440087171 1278 3921 2583 2910 552 756 513 1942 2144 1784 215 1574 M13441 GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. 20/46 Gene Ontology BP GO:0038034 0.0630767995085419 0.144268758678897 2175 1744.45454545455 1784 0.0059055806708635 140 1.77398125851213 1.77398125851213 1 5.66191403940977 2175 1784 2184 1147 2743 3973 1957 752 140 633 1701 1575 M12079 GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. 11/37 Gene Ontology BP GO:0030320 0.0234153812737774 0.0732105153226588 4425 1950.45454545455 1785 0.00215167067605024 309 1.14211151586662 -0.802911170417016 -1 4.92237596536882 4424 1183 1390 991 635 2451 1926 2112 309 1785 4249 1576 M14700 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. 20/46 Gene Ontology BP GO:0097192 0.0652471488596201 0.147489051682189 2180 1746.54545454545 1785 0.00611514546373156 141 1.77398125851213 1.77398125851213 1 5.5973543993817 2176 1785 2185 1148 2744 3974 1958 764 141 635 1702 1577 M15642 GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that modulates the frequency, rate or extent of response to oxidative stress. 36/89 Gene Ontology BP GO:1902882 0.0839184282471183 0.158445571591463 1750 2098.63636363636 1785 0.00793650793650794 910 0.715858725339802 0.715858725339802 1 2.17415059557999 1748 2250 2366 2466 3670 1785 985 910 1197 4322 1386 1578 M10714 GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. 25/77 Gene Ontology BP GO:0002286 0.0180197121055297 0.0616870981209885 1370 1813.27272727273 1786 0.00165172932356637 420 0.99922911023935 0.988741116265153 1 4.58868156481575 1368 2256 1353 2664 3079 1786 1895 420 2088 1378 1659 1579 M14390 GO_CELL_FATE_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_DETERMINATION.html A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. 22/63 Gene Ontology BP GO:0001709 0.0193654782348825 0.0645914426865605 1260 2004.54545454545 1786 0.00177618849301102 576 1.07272638267715 -1.07272638267715 -1 4.84483831697531 1256 882 973 1786 576 2345 1350 3932 3559 2361 3030 1580 M12185 GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. 11/33 Gene Ontology BP GO:1903409 0.107089024825981 0.193017990010494 3400 2217.27272727273 1787 0.0102442929028182 734 1.31505585488108 1.31505585488108 1 3.56610577179139 3396 734 1600 1174 1345 3837 2999 1541 2345 1787 3632 1581 M13613 GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. 11/24 Gene Ontology BP GO:0070884 0.0149423009178264 0.0540741256129912 1800 1675 1790 0.00136770581645585 490 1.21455215107271 1.21455215107271 1 5.84122063372895 1271 1120 1552 1872 490 1837 1798 3189 1790 1800 1706 1582 M13032 GO_EMBRYONIC_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PATTERN_SPECIFICATION.html The process that results in the patterns of cell differentiation that will arise in an embryo. 32/93 Gene Ontology BP GO:0009880 0.054670167109444 0.131044701026922 1790 1812.63636363636 1791 0.00509799569199146 790 1.25104032444903 1.34019729533498 1 4.19114691595214 1789 790 794 1971 1125 2577 1791 3062 2074 975 2991 1583 M13318 GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. 10/31 Gene Ontology BP GO:1901623 0.0208338583698702 0.0677539591567336 3020 2019.90909090909 1791 0.00191216451641861 663 1.46584243959724 1.46584243959724 1 6.50479030366649 3020 1124 663 1791 718 4517 1980 2085 786 1696 3839 1584 M11797 GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 20/46 Gene Ontology BP GO:0043516 0.000790374262546218 0.00695133982527408 1150 1776.36363636364 1792 7.18780323741949e-05 77 1.60640719314898 1.60640719314898 1 13.1583223598273 1147 4457 2628 2917 77 2292 1792 607 435 2284 904 1585 M12810 GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION.html Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 11/20 Gene Ontology BP GO:0090129 0.0839184282471183 0.158445571591463 2455 2057.54545454545 1792 0.00793650793650794 584 1.51935086267539 -1.51935086267539 -1 4.61445459305512 2451 2314 1840 1745 4404 1284 4238 1039 942 1792 584 1586 M15949 GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN.html The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. 4/16 Gene Ontology BP GO:0002016 0.0765897756730953 0.158445571591463 2865 2095.36363636364 1793 0.00793650793650794 28 0.543190368111254 -0.592807983301267 -1 1.64973565384883 2865 453 4485 375 3694 2100 1402 1466 28 4388 1793 1587 M13196 GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of the same species. 11/65 Gene Ontology BP GO:0051703 0.0516631277268281 0.125719026224142 2145 1748.90909090909 1796 0.00481070850976467 429 1.51935086267539 -1.51935086267539 -1 5.1939380359168 2145 2752 2762 1230 2370 1029 864 2883 978 1796 429 1588 M11112 GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE.html A process that modulates the size of a cellular component. 206/480 Gene Ontology BP GO:0032535 0.0133375540364285 0.0500924017811142 1315 1610 1797 0.0012199187553005 190 1.11101856890863 1.20978436254255 1 5.48337706395161 1312 190 599 534 2102 3732 1967 1797 1829 1669 1979 1589 M10794 GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. 22/44 Gene Ontology BP GO:0051145 0.03306407087292 0.0924807444298798 1095 1760.63636363636 1798 0.00305197351209051 727 1.54868492583296 -1.38916827744188 -1 6.07812023111463 1091 2259 727 1798 2443 939 790 2840 3238 1259 1983 1590 M12416 GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. 12/27 Gene Ontology BP GO:1901533 0.265315519578844 0.381498902881564 1330 2037.54545454545 1798 0.0276394033542099 1320 0.580723307924659 -0.585473054826234 -1 0.922526627354326 1329 1798 1403 2145 1896 1320 2773 1615 3187 3481 1466 1591 M13241 GO_CELLULAR_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions at the level of a cell. 11/37 Gene Ontology BP GO:0030002 0.0234153812737774 0.0732105153226588 4425 1961.63636363636 1798 0.00215167067605024 310 1.14211151586662 -0.802911170417016 -1 4.92237596536882 4425 1184 1391 992 636 2452 1927 2213 310 1798 4250 1592 M13561 GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 11/31 Gene Ontology BP GO:2000463 0.0426558655230441 0.10960220455091 1170 1929.72727272727 1799 0.00395509927545801 386 1.51935086267539 -1.51935086267539 -1 5.53755795814702 1170 4343 2007 3049 3172 834 1067 1563 1837 1799 386 1593 M11568 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of epithelial cell proliferation. 98/243 Gene Ontology BP GO:0050679 0.00793858722941466 0.0346092586912415 3095 1812 1800 0.00072430716089394 514 1.48047101437599 1.49559095061769 1 8.20918778454858 2035 696 550 514 1800 3093 2937 3092 1130 796 3289 1594 M10074 GO_FOREBRAIN_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. 16/71 Gene Ontology BP GO:0021884 0.0784094328241437 0.158445571591463 1635 1728.72727272727 1801 0.00739562806069598 508 1.21442039933652 1.30628405292381 1 3.6883434414198 1634 2023 1257 2234 3140 1801 1365 819 2220 508 2015 1595 M13781 GO_CELLULAR_RESPONSE_TO_CHOLESTEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CHOLESTEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. 11/28 Gene Ontology BP GO:0071397 0.00109945016496701 0.00830040181453953 3960 1866 1801 1e-04 71 1.36279305893447 -0.816391131298516 -1 10.764368050557 3960 135 1203 71 200 2857 2966 3665 182 1801 3486 1596 M13782 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. 11/24 Gene Ontology BP GO:1901018 0.291851667727254 0.410139707445999 2235 1894.27272727273 1802 0.0308858592049851 863 1.13975148755868 -1.13975148755868 -1 1.67457603687668 2235 1041 2342 1400 2936 884 863 3633 2526 1802 1175 1597 M10833 GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. 13/34 Gene Ontology BP GO:0031290 0.0102779907166178 0.0413524357861842 2295 1730.36363636364 1803 0.000938756727262566 390 1.29332830234452 1.24511675505387 1 6.79195550323711 2292 1656 775 516 390 2971 3083 2065 1803 406 3077 1598 M10935 GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 15/26 Gene Ontology BP GO:0071498 0.0461984099858212 0.115860574033061 685 1472.90909090909 1804 0.00429073258044004 528 1.29994081892301 1.29994081892301 1 4.61887815265565 682 2117 1347 1968 2124 1804 528 667 2012 2061 892 1599 M12500 GO_LYMPHOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. 200/544 Gene Ontology BP GO:0046649 0.0839184282471183 0.158445571591463 1495 1901.36363636364 1804 0.00793650793650794 1209 1.33807608049295 1.36137524334586 1 4.06390088500249 1495 2612 1226 1845 1804 3084 1945 1789 1209 1558 2348 1600 M12551 GO_VESICLE_CYTOSKELETAL_TRAFFICKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_CYTOSKELETAL_TRAFFICKING.html The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. 30/56 Gene Ontology BP GO:0099518 0.0473073696150475 0.117900223898371 1380 1965.54545454545 1804 0.00439603229330696 268 0.802844411190204 -0.802844411190204 -1 2.8295259718591 1377 2525 2863 3476 1476 268 1450 1804 2457 3519 406 1601 M14120 GO_SOCIAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOCIAL_BEHAVIOR.html Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. 11/65 Gene Ontology BP GO:0035176 0.0516631277268281 0.125719026224142 2150 1749.18181818182 1804 0.00481070850976467 430 1.51935086267539 -1.51935086267539 -1 5.1939380359168 2146 2753 2763 1231 2371 1030 865 2869 979 1804 430 1602 M15470 GO_CELLULAR_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 144/401 Gene Ontology BP GO:1901653 0.0461203559110202 0.115860574033061 2135 2040.54545454545 1804 0.00428332525802934 692 1.28055611947026 1.39448611299988 1 4.55000150573589 2133 692 766 780 1434 4230 2871 2929 1804 1085 3722 1603 M12186 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. 13/35 Gene Ontology BP GO:0051770 0.055555157719601 0.132331128588437 2160 1732.54545454545 1806 0.00518270434911385 716 1.19317718245127 1.19317718245127 1 3.97808295125031 2158 2603 2486 2459 1158 2120 1249 716 1806 873 1430 1604 M14610 GO_REGULATION_OF_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROVILLUS_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. 11/32 Gene Ontology BP GO:0032530 0.0176351558896455 0.0608321164900624 3865 2314.81818181818 1806 0.00161619327326837 210 1.30464073117713 1.30464073117713 1 6.02121675905598 3863 736 1786 264 550 3892 4250 4490 210 1806 3616 1605 M15475 GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the C-terminal amino acid residue in a protein. 8/16 Gene Ontology BP GO:0018410 0.00744094471236271 0.0330333504943142 2395 2135.45454545455 1807 0.000746597821217194 336 0.757413120848284 -0.757413120848284 -1 4.25803283330877 2391 1706 4413 2208 336 1343 2921 1807 700 4287 1378 1606 M14754 GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. 170/471 Gene Ontology BP GO:0034110 0.00239219783887561 0.0147895799812243 920 1666.36363636364 1808 0.000217709362925017 439 1.30884724133196 1.33785649941672 1 9.09196515413848 919 1918 439 1293 2210 2937 1820 1808 1200 1487 2299 1607 M13129 GO_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction. 11/38 Gene Ontology BP GO:0019098 0.0308960461716916 0.0882228427891537 2345 1840.90909090909 1809 0.00284896972059623 497 2.06322935667965 2.06322935667965 1 8.25786812237357 2343 2682 1520 1206 744 2101 3332 2223 497 1793 1809 1608 M15033 GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. 11/54 Gene Ontology BP GO:0045581 0.049916321897039 0.122366147079172 285 1682.72727272727 1809 0.00464420182946261 284 1.21455215107271 1.21455215107271 1 4.20609911775551 284 2219 2298 2786 4194 368 355 718 2828 1809 651 1609 M12569 GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. 19/63 Gene Ontology BP GO:0061005 0.00218789605818708 0.0139538480743992 3965 2135 1810 0.000199097722833468 428 1.59728558834855 -1.38916827744188 -1 11.2487782539286 3962 884 428 953 1810 3356 3857 2755 846 1121 3513 1610 M12437 GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of granulocyte differentiation. 7/21 Gene Ontology BP GO:0030852 0.112068450194514 0.200238622255417 1630 2014.27272727273 1812 0.0118157020578716 624 0.256078604595723 -0.306140087695783 -1 0.678917784146499 1627 1812 3908 2094 3913 624 685 980 2010 3488 1016 1611 M15718 GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of smoothened signaling. 11/42 Gene Ontology BP GO:0045880 0.161385165508919 0.258740097879113 2520 1837.81818181818 1812 0.0158730158730159 970 1.44141515827619 1.44141515827619 1 3.21244143886464 2517 970 2296 1391 1723 1039 2186 2333 1311 1812 2638 1612 M16579 GO_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that modulates the frequency, rate or extent of lymphocyte migration. 21/59 Gene Ontology BP GO:2000401 0.0177879916708685 0.0611775150576612 2580 2083.45454545455 1812 0.0016303149994651 550 1.22779392099841 -0.989745402399581 -1 5.65509133646462 2578 1029 637 1290 1597 4520 2893 1812 550 2339 3673 1613 M10229 GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. 88/229 Gene Ontology BP GO:0043524 0.0169894129794684 0.0591318174390342 2185 1802.27272727273 1813 0.00155654993399896 541 1.4866770607585 1.60230586369389 1 6.93083337989623 2181 2700 846 1019 541 3703 1813 1446 1996 935 2645 1614 M12070 GO_POSITIVE_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASODILATION.html Any process that activates or increases the frequency, rate or extent of vasodilation. 12/43 Gene Ontology BP GO:0045909 0.0132581657015579 0.0499400653053853 530 1661.18181818182 1813 0.00121261326449111 530 0.858982002181133 0.858982002181133 1 4.24377597925616 530 2429 597 2346 1813 940 662 1820 2385 3407 1344 1615 M10892 GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. 26/70 Gene Ontology BP GO:0032272 0.0839184282471183 0.158445571591463 3190 2161.45454545455 1815 0.00793650793650794 622 0.916001837656024 -0.97975757930076 -1 2.78200973241234 3188 791 2887 898 4078 1128 3508 1815 622 3113 1748 1616 M10549 GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION.html Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. 7/14 Gene Ontology BP GO:1901970 0.000722448952386523 0.00655142673033326 1395 1887.36363636364 1816 7.22683929527634e-05 84 1.73041933125535 1.73041933125535 1 14.3431462189629 1391 3194 3601 2249 2453 1816 856 84 3008 1395 714 1617 M10305 GO_URETER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_URETER_DEVELOPMENT.html The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. 6/21 Gene Ontology BP GO:0072189 0.0765897756730953 0.158445571591463 2690 1872.18181818182 1817 0.00793650793650794 58 1.80540289925521 1.80540289925521 1 5.48322965122361 2686 670 3564 428 2289 2637 1682 1817 58 1305 3458 1618 M10647 GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition. 7/14 Gene Ontology BP GO:0045842 0.000935621797724238 0.00777118426982761 1395 1890.18181818182 1817 9.36015955973647e-05 93 1.73041933125535 1.73041933125535 1 13.8560918222052 1392 3195 3614 2250 2454 1817 857 93 3009 1396 715 1619 M15721 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. 32/65 Gene Ontology BP GO:2001238 0.022919769881484 0.0722938122009036 3405 2065.27272727273 1817 0.00210564469140736 390 1.59530076100994 1.69807544305201 1 6.90870986630169 3404 390 1817 532 626 3488 4279 1821 1270 978 4113 1620 M10240 GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that activates or increases the frequency, rate or extent of protein binding. 58/132 Gene Ontology BP GO:0032092 0.00410723260677862 0.0218190858046604 2080 1674.54545454545 1818 0.000374083690829056 227 1.25956269341659 1.25956269341659 1 7.94217380520341 2079 1218 1151 1408 227 3302 1987 640 1818 1827 2763 1621 M15715 GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. 7/14 Gene Ontology BP GO:1902101 0.00164118644698055 0.011222428090325 1395 1973.09090909091 1818 0.000164239978016008 134 1.73041933125535 1.73041933125535 1 12.8077800720303 1393 3196 4446 2251 2455 1818 858 134 3010 1427 716 1622 M16223 GO_ADAPTATION_OF_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTATION_OF_SIGNALING_PATHWAY.html The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. 11/26 Gene Ontology BP GO:0023058 0.0154798134303637 0.0552867490439835 4255 2361.09090909091 1820 0.00141725626292746 129 0.84436857560761 0.941496485554832 1 4.0300040017601 4251 129 1630 1197 504 2969 4489 3191 1654 1820 4138 1623 M11194 GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. 24/79 Gene Ontology BP GO:0002792 0.0374825000341767 0.100028388583698 210 1673.90909090909 1822 0.00346697893795779 208 1.16533572062244 1.16533572062244 1 4.42287586216989 208 2563 1822 3043 2511 330 339 1043 3331 2412 811 1624 M11588 GO_CREATINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CREATINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. 4/10 Gene Ontology BP GO:0006600 0.0311952376857815 0.0887084901106234 2235 2052.72727272727 1822 0.00316420043967842 785 0.452215543673541 0.432159911460461 1 1.80585480142568 2231 986 3773 1441 785 2006 1522 1716 3003 3295 1822 1625 M10072 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY.html Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 66/138 Gene Ontology BP GO:0090175 0.0593885904173866 0.138354854645221 4010 2310.09090909091 1824 0.00555046433859659 605 1.46002740873314 1.60214475053423 1 4.76062785815514 4007 1473 2898 1824 1051 1478 3488 3714 605 1347 3526 1626 M15028 GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of B cell differentiation. 12/26 Gene Ontology BP GO:0045579 0.044083974541403 0.112234699235573 830 1937.90909090909 1825 0.00409026736372881 230 0.347115471140709 -0.428015035199516 -1 1.25154559997661 826 2572 2502 3034 1825 230 683 1272 3584 4159 630 1627 M16607 GO_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION.html The addition of tubulin heterodimers to one or both ends of a microtubule. 13/34 Gene Ontology BP GO:0046785 0.0138870013876265 0.0517059722876905 970 1743.72727272727 1825 0.00127049477279732 133 0.583871951991638 -0.583871951991638 -1 2.85115542085767 967 3061 2705 2404 1991 133 182 875 1825 4540 498 1628 M14237 GO_REGULATION_OF_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. 248/729 Gene Ontology BP GO:0044057 2.22117859405284e-06 6.56874663196647e-05 885 1663.45454545455 1826 2.01925530601553e-07 149 1.42699440065893 1.37948987094958 1 22.655166887789 882 2476 149 1826 2418 2422 1527 1958 1593 967 2080 1629 M16403 GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. 12/29 Gene Ontology BP GO:0048384 0.0839184282471183 0.158445571591463 2410 1944.45454545455 1826 0.00793650793650794 260 1.26530448687738 1.26530448687738 1 3.84288464532704 2407 1336 1785 1208 4089 1748 2541 2297 260 1892 1826 1630 M11434 GO_RETINOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. 10/44 Gene Ontology BP GO:0042572 0.0839184282471183 0.158445571591463 1550 1757.18181818182 1830 0.00793650793650794 616 1.02401096892853 1.02401096892853 1 3.11004668829612 1547 1662 1895 2684 2753 1830 616 2012 657 1681 1992 1631 M13427 GO_ENDOTHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 58/132 Gene Ontology BP GO:0003158 0.0028121229741838 0.0166115610294343 390 1780.90909090909 1830 0.000255974907418263 388 1.88765595208598 1.88765595208598 1 12.7511666183737 388 2733 452 2657 3459 1491 890 1865 2543 1830 1282 1632 M15546 GO_ACTIN_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 118/243 Gene Ontology BP GO:0007015 0.0586069592870812 0.137200667935398 1830 1815.90909090909 1830 0.00547536818657656 726 1.18527917668445 1.35228489915826 1 3.88114061898245 1830 928 807 726 1289 4313 2246 2129 962 2451 2294 1633 M13787 GO_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell. 78/260 Gene Ontology BP GO:0050707 0.00661976375108895 0.030431250590402 1200 1698 1831 0.000603615166047783 462 1.33059168911441 1.33059168911441 1 7.66030487581343 1197 2285 532 2537 1530 2865 1831 462 2278 1108 2053 1634 M14021 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 29/78 Gene Ontology BP GO:0002066 0.0329861351172527 0.0924152744466946 1475 1751.81818181818 1831 0.00304466880215658 241 1.54519113046724 1.60691562657909 1 6.06621206514384 1474 3239 1285 1831 2838 2203 1384 2258 241 278 2239 1635 M15611 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 20/48 Gene Ontology BP GO:0050654 0.232850105696956 0.342669743502683 1945 1896 1832 0.0238095238095238 1301 1.35827470555819 1.35827470555819 1 2.39808083364627 1943 1735 1530 1347 2063 3392 2089 1301 1832 2306 1318 1636 M11248 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD.html The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). 14/61 Gene Ontology BP GO:0043153 0.0211114982142062 0.0681645940254237 2540 2039.36363636364 1833 0.00193789556368014 601 0.849254971022537 0.849254971022537 1 3.76017588779211 2540 1037 1487 1630 601 1790 1833 2541 3368 3199 2407 1637 M16782 GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 184/547 Gene Ontology BP GO:0034762 0.0550208336238643 0.131566902405086 2245 2126.72727272727 1835 0.00513155181609028 609 1.60879265925064 1.85580101427731 1 5.37911609366752 2241 2614 796 1638 1835 4362 3025 1598 914 609 3762 1638 M10250 GO_FATTY_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 46/95 Gene Ontology BP GO:0009062 0.0261157037354003 0.07899362374167 785 1633.18181818182 1836 0.00240281540031902 252 0.736186088956347 -0.736186088956347 -1 3.08061325235167 784 1836 2737 2113 677 252 2473 1269 2396 2985 443 1639 M13915 GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT.html Any apoptotic process that is involved in anatomical structure development. 16/38 Gene Ontology BP GO:1902742 0.000746410461501299 0.00670325681383082 520 1649.54545454545 1836 6.78785292831937e-05 33 0.421243793038977 0.496465290455533 1 3.47570714378718 517 2388 1836 2385 3345 375 33 187 3099 3873 107 1640 M12988 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 33/84 Gene Ontology BP GO:0046364 0.101137955716575 0.184078215755413 1920 1920.72727272727 1839 0.00964641836151262 379 1.47423048862313 -1.23889395501682 -1 4.11299842254837 1920 2291 2157 2289 4236 379 1839 1528 1805 1760 924 1641 M13703 GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 15/45 Gene Ontology BP GO:0098815 0.0855370570290545 0.160522821720471 1245 1998.54545454545 1839 0.00809598893480624 545 1.51935086267539 -1.51935086267539 -1 4.58183136752935 1245 4042 2299 2743 3606 751 1133 1704 1839 2077 545 1642 M14635 GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. 14/38 Gene Ontology BP GO:0002367 0.021268186070026 0.0684800193641685 1020 1782.81818181818 1839 0.00195241997675038 603 1.37333636438773 1.37333636438773 1 6.07015556778926 1016 3541 1967 2620 603 1429 2007 1045 2624 920 1839 1643 M14642 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 34/84 Gene Ontology BP GO:0010803 0.369168243142213 0.490008048287392 1590 1933.54545454545 1840 0.041018293735024 1247 1.46528721629209 1.46528721629209 1 1.72308578862971 1590 2014 1755 1642 2255 2490 1247 1509 2655 1840 2272 1644 M14708 GO_GLUTATHIONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. 34/71 Gene Ontology BP GO:0006749 0.0797921691258245 0.158445571591463 2170 1648 1840 0.00753110993907976 386 1.92405856780073 2.44876292098825 1 5.84360144432528 2168 623 862 1112 1840 1146 2517 3621 386 1841 2012 1645 M12357 GO_DETECTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS.html The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. 20/46 Gene Ontology BP GO:0016048 0.161385165508919 0.258740097879113 1660 2214.27272727273 1841 0.0158730158730159 1307 1.31394404283802 1.31394404283802 1 2.92835014763378 2984 1436 1307 1841 1656 4070 1660 2264 1397 2288 3454 1646 M16337 GO_AXONAL_FASCICULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_FASCICULATION.html The collection of axons into a bundle of rods, known as a fascicle. 14/43 Gene Ontology BP GO:0007413 0.0112526063478162 0.044163864136019 1380 1893.90909090909 1841 0.00102823426872834 423 1.31394404283802 1.31394404283802 1 6.75774656989606 1376 2674 1561 2893 423 2365 1841 1506 3091 2036 1067 1647 M10096 GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION.html The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle. 6/18 Gene Ontology BP GO:0002031 0.104110065473896 0.188674096016901 3275 2093.72727272727 1842 0.0109335607924107 442 0.782116433650225 -0.866673876389979 -1 2.15025400668742 3271 442 3532 1598 1379 1661 2385 1824 2142 2955 1842 1648 M16487 GO_ADIPOSE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADIPOSE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. 23/50 Gene Ontology BP GO:0060612 0.0839184282471183 0.158445571591463 1320 1701.90909090909 1842 0.00793650793650794 785 0.918519785814287 0.969584113072172 1 2.78965704925656 1318 1849 1953 1445 2135 1842 785 2976 897 2397 1124 1649 M14044 GO_REGULATION_OF_MITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOPHAGY.html Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy). 34/62 Gene Ontology BP GO:1903146 0.00879438953771256 0.0370529497491828 3260 2005.90909090909 1844 0.000802703879873441 354 0.967708322190554 0.967708322190554 1 5.25708646087834 3257 1844 3067 2519 354 764 1700 2611 1523 2608 1818 1650 M16570 GO_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_GROWTH.html The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. 88/205 Gene Ontology BP GO:0016049 0.0458114771009969 0.115818019592957 1845 1721 1844 0.00425401809939916 765 1.40437318499598 1.50485120815071 1 4.99079196444745 1844 1515 765 1930 2426 3244 2018 1062 1025 937 2165 1651 M12514 GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM.html Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. 262/924 Gene Ontology BP GO:0098542 0.000889343965462319 0.00749375104253493 4560 2299.81818181818 1846 8.08821530835143e-05 367 1.45649322486129 1.63785996573977 1 11.7499520172013 4559 688 367 1846 1465 1359 4474 4009 1114 2130 3287 1652 M13755 GO_ENDODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. 46/113 Gene Ontology BP GO:0007492 0.000198208128246203 0.0024281803151639 1415 1983.72727272727 1846 1.80205443619736e-05 284 1.45217620209152 1.46778240338295 1 14.4129068600706 1415 2008 284 1835 1693 3616 2632 1846 2641 892 2959 1653 M12623 GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 27/98 Gene Ontology BP GO:0071384 0.000737407794184643 0.00664812502601806 1850 1819.81818181818 1847 6.70595525936953e-05 90 0.610915338006002 0.662965888795203 1 5.04901541307795 1847 268 352 470 90 2946 739 4169 2519 3540 3078 1654 M13529 GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN.html The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. 7/25 Gene Ontology BP GO:0032490 0.0263408295050313 0.0793818852857974 1430 2243.36363636364 1847 0.00266583674965048 532 1.20763157545096 1.20763157545096 1 5.04364317217772 1430 3694 4092 1678 4450 2094 2609 532 1696 555 1847 1655 M11158 GO_L_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSPORT.html The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/67 Gene Ontology BP GO:0015807 0.0548843999971576 0.131379766056942 2510 2288.45454545455 1848 0.00511849480830637 1003 1.32018948758027 1.4836078808557 1 4.41724801437673 2506 1535 1277 1848 1003 3912 2689 4275 1750 1291 3087 1656 M11914 GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. 13/66 Gene Ontology BP GO:0016339 0.0839184282471183 0.158445571591463 3860 2178 1850 0.00793650793650794 323 1.59571678613809 -1.59571678613809 -1 4.84638725255182 3857 1973 1691 1423 1815 4441 3557 1850 323 872 2156 1657 M12722 GO_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. 242/660 Gene Ontology BP GO:0050708 0.00647197831587955 0.0299296766141721 805 1689.54545454545 1850 0.000590099674597807 530 1.17478898321148 1.26465622784698 1 6.79552459098476 803 2280 530 2505 1606 2063 2029 856 2594 1850 1469 1658 M13345 GO_REGULATION_OF_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 856/2098 Gene Ontology BP GO:0080134 0.0376654215064643 0.100275545902818 1860 2139.90909090909 1850 0.00383194868379361 588 1.29670950772079 1.3630374531409 1 4.91621218404226 1857 588 4056 1429 882 3805 1850 1441 1613 2663 3355 1659 M13643 GO_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 55/151 Gene Ontology BP GO:0007219 0.161385165508919 0.258740097879113 4545 2297.18181818182 1852 0.0158730158730159 775 1.22910183318165 -1.15581016884698 -1 2.73926470024198 4541 775 1852 1903 1781 2487 4481 1632 1564 1734 2519 1660 M13574 GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 39/111 Gene Ontology BP GO:0051588 0.0839184282471183 0.158445571591463 1345 2012.63636363636 1854 0.00793650793650794 929 1.69943746909448 1.69943746909448 1 5.16139966583895 1345 2662 1165 2045 4481 2650 2065 1784 929 1159 1854 1661 M16475 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. 30/90 Gene Ontology BP GO:1902305 0.202267738481442 0.309943600583939 1880 2071.90909090909 1856 0.0203342538781016 1023 1.49875549878316 1.49875549878316 1 2.89410677434242 1880 1023 1837 1506 4041 2936 2319 1203 1856 1648 2542 1662 M16547 GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION.html Any process that modulates the frequency, rate or extent of sister chromatid segregation. 40/81 Gene Ontology BP GO:0033045 0.387169287820459 0.507947726292848 1520 1938 1857 0.0435388811873348 942 1.24626748550355 -1.00419156262766 -1 1.3916598091936 1520 1843 2362 1857 2572 942 1716 1669 2856 2054 1927 1663 M14429 GO_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. 72/179 Gene Ontology BP GO:0006006 0.0319948814756042 0.0902504463494716 4130 2290.90909090909 1858 0.00295180791259077 762 1.16697579633442 -1.0421890644243 -1 4.62699020203022 4126 1472 1858 1431 762 1171 4405 3447 2039 1481 3008 1664 M14611 GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. 10/28 Gene Ontology BP GO:0031146 0.0495736446327176 0.121783297370216 1235 2003.45454545455 1861 0.00461157026399763 528 0.375260402097293 -0.461665466815021 -1 1.30251284897258 1231 1984 2438 2625 968 528 1861 1752 3321 4053 1277 1665 M11761 GO_AXON_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_REGENERATION.html The regrowth of axons following their loss or damage. 12/34 Gene Ontology BP GO:0031103 0.0839184282471183 0.158445571591463 2875 2011.09090909091 1862 0.00793650793650794 48 2.24458518468169 2.24458518468169 1 6.81708002379904 2871 560 1328 779 1986 4637 4459 1066 48 1862 2526 1666 M12770 GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. 10/22 Gene Ontology BP GO:0061029 0.0797405508165267 0.158445571591463 1865 1932.09090909091 1862 0.00752604900133732 724 1.50997752516396 1.50997752516396 1 4.58598661939869 1862 2938 1721 2412 1197 2513 1186 3060 1313 724 2327 1667 M12445 GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH.html Any process that controls the length of actin filaments in a cell. 90/207 Gene Ontology BP GO:0030832 0.0839184282471183 0.158445571591463 2470 2120.36363636364 1863 0.00793650793650794 495 0.886990544643103 0.95998889136716 1 2.69389888350458 2470 495 1845 606 1863 4528 2292 1453 1110 2867 3795 1668 M12842 GO_CILIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MORPHOGENESIS.html A process that is carried out at the cellular level and in which the structure of a cilium is organized. 122/309 Gene Ontology BP GO:0060271 0.000808574286242461 0.00701721572153971 475 1561.54545454545 1863 7.35337834179678e-05 15 0.913083894186696 -0.679531930595354 -1 7.46500973081962 471 1208 3263 1863 2581 15 710 1976 2124 2838 128 1669 M14927 GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. 62/168 Gene Ontology BP GO:0055067 0.026935680630736 0.0802196056244435 1990 1769.54545454545 1863 0.00247920303260698 429 1.47120729840032 1.80389653778312 1 6.11900042642891 1990 865 701 655 4639 2087 1863 2300 429 538 3398 1670 M14697 GO_CELLULAR_COMPONENT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MORPHOGENESIS.html The process in which cellular structures, including whole cells or cell parts, are generated and organized. 484/1351 Gene Ontology BP GO:0032989 1.55938953827423e-05 0.000348088732029195 1985 1629.18181818182 1864 1.41763690140576e-06 132 1.37706515698227 1.54689006597154 1 18.0769703501615 1981 462 187 526 1864 3317 2953 2023 903 132 3573 1671 M12956 GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of muscle cell differentiation. 91/264 Gene Ontology BP GO:0051147 0.183891152137903 0.287721813166887 2030 2020.27272727273 1865 0.0183038252138897 971 1.49311743273297 1.57719564274413 1 3.06633998370573 2029 1146 1075 1339 2486 4466 1865 2254 1816 971 2776 1672 M13310 GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. 10/35 Gene Ontology BP GO:0002579 0.161385165508919 0.258740097879113 705 1911 1865 0.0158730158730159 702 0.53768699458399 0.649920836897579 1 1.1983278880222 702 2794 1793 2604 2304 1088 806 1969 1393 3703 1865 1673 M11034 GO_C21_STEROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 11/43 Gene Ontology BP GO:0008207 0.000212345959683271 0.00254103683198306 1880 2037.72727272727 1866 1.93060416613148e-05 39 0.463303379290357 0.619379432980596 1 4.5636068873192 1879 1605 2209 1628 39 1866 1206 4380 1733 3145 2725 1674 M14609 GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 12/29 Gene Ontology BP GO:0010888 0.224314005279928 0.336398555075809 1315 2214.45454545455 1866 0.0228270193028794 1134 0.537543267410471 0.611264564950829 1 0.965418727119248 1315 2028 1134 2383 4220 1679 1340 1255 3087 4052 1866 1675 M16707 GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 4/13 Gene Ontology BP GO:0051533 0.0322563708351832 0.0907674725986396 1870 2243.09090909091 1867 0.00327343785023427 802 0.539542346297222 0.590841410752441 1 2.13417269574406 1867 985 4608 1754 802 2360 2964 929 1650 4573 2182 1676 M11339 GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/33 Gene Ontology BP GO:0032373 0.0299038920822989 0.0860779733032323 680 1674.45454545455 1868 0.00275620667452629 329 0.418066870412733 0.550283043881278 1 1.69023315965792 676 2463 2025 2807 1868 732 329 544 3362 3229 384 1677 M12334 GO_FATTY_ACID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. 12/37 Gene Ontology BP GO:0055089 0.0440913399538413 0.112234699235573 2140 1771.09090909091 1868 0.00409096496319717 655 1.23889395501682 -1.23889395501682 -1 4.46690628136299 2137 2680 1657 2569 1103 1403 703 655 2565 1868 2142 1678 M11600 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/67 Gene Ontology BP GO:0043268 0.0839184282471183 0.158445571591463 3475 2065 1869 0.00793650793650794 1173 1.14050880909856 -1.28127221255727 -1 3.46386489242548 3472 1324 1911 1869 1335 1537 2358 3673 1173 1546 2517 1679 M12448 GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 12/29 Gene Ontology BP GO:0060099 0.0143792463197594 0.0527728071909633 890 1935.09090909091 1869 0.00131582713250034 621 1.9083122944764 1.9083122944764 1 9.25439679083814 889 2750 621 2589 3739 1669 921 1579 2386 1869 2274 1680 M15839 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/33 Gene Ontology BP GO:0032376 0.0291724162009745 0.0844435962725215 680 1777.45454545455 1869 0.00268787137503657 330 0.418066870412733 0.550283043881278 1 1.70344470194906 677 2464 2026 2808 1869 733 330 534 3363 4363 385 1681 M12177 GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of leukocyte differentiation. 132/409 Gene Ontology BP GO:1902105 0.0627724162900777 0.143776375560781 825 2098.90909090909 1871 0.00587622530224993 700 1.58023504775979 1.58023504775979 1 5.05245146555476 1624 2768 824 1871 3080 3962 2501 1851 822 700 3085 1682 M13822 GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. 29/84 Gene Ontology BP GO:1904888 0.0102633849481215 0.0413524357861842 2700 1850.36363636364 1871 0.000937416409732225 305 1.42528996480022 1.42528996480022 1 7.48495645120284 2700 526 1871 830 388 3548 3119 2607 305 898 3562 1683 M10507 GO_POSITIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DEATH.html Any process that activates or increases the frequency, rate or extent of neuron death. 57/112 Gene Ontology BP GO:1901216 0.00673311460027958 0.0307695384735218 1400 2184.18181818182 1872 0.000613982733703966 306 1.33838686015354 1.61112816865721 1 7.68079077623188 1399 3973 1864 2894 306 3384 1488 1701 2693 2452 1872 1684 M11735 GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. 6/17 Gene Ontology BP GO:0060389 0.0555907914364882 0.132331128588437 4235 2594 1872 0.00570324669786615 1064 1.08918898596586 1.08918898596586 1 3.63138366997639 4231 1131 3797 1139 1064 1872 4009 4035 1644 1313 4299 1685 M15503 GO_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_CHEMOTAXIS.html The movement of a monocyte in response to an external stimulus. 13/54 Gene Ontology BP GO:0002548 0.00329739997660521 0.0187161712608533 1650 2046.09090909091 1872 0.0003002138704537 288 0.900261201126601 1.07236730522795 1 5.90425299553853 1649 1179 459 1395 1899 3398 1872 2999 288 4294 3075 1686 M13331 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. 23/38 Gene Ontology BP GO:0030511 0.0597660986192562 0.138892220755598 2105 1856 1874 0.00558675421209185 811 1.08918898596586 1.08918898596586 1 3.54449591428883 2103 1108 811 1350 1788 2032 1806 1874 1966 2392 3186 1687 M14730 GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by a ligand binding to an receptor located within a cell. 86/294 Gene Ontology BP GO:0030522 0.0839184282471183 0.158445571591463 1875 2109.27272727273 1874 0.00793650793650794 1034 1.22489520718675 1.22489520718675 1 3.72015671535483 1874 1723 1816 1399 3686 2687 1811 2557 1034 1903 2712 1688 M16219 GO_SINGLE_ORGANISM_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CATABOLIC_PROCESS.html A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism. 493/1233 Gene Ontology BP GO:0044712 0.000249418816408158 0.00283113699134961 4235 2024.18181818182 1874 2.26770089140379e-05 174 1.13473507958747 1.35860104474383 1 10.9750827335921 4234 174 297 1110 497 688 4188 4279 1874 2550 2375 1689 M11198 GO_HEXOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. 6/22 Gene Ontology BP GO:0035428 0.131556965085471 0.228002608768885 785 2117.90909090909 1875 0.0140063145065231 582 0.598553450001734 0.648747668033277 1 1.4587669260515 781 1875 3705 2896 2649 823 582 1323 3688 3186 1789 1690 M12931 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. 15/35 Gene Ontology BP GO:0071634 0.232850105696956 0.342669743502683 1570 2144.09090909091 1875 0.0238095238095238 1183 0.481913194475145 0.551612438825346 1 0.850834363820467 1567 3058 2044 2358 3034 1629 1183 1444 1787 3606 1875 1691 M13231 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. 12/36 Gene Ontology BP GO:2000142 0.0839184282471183 0.158445571591463 1510 2073.45454545455 1875 0.00793650793650794 183 1.70820157422404 1.70820157422404 1 5.18801732615965 1510 2857 3167 2414 3827 1001 915 3845 183 1875 1214 1692 M15786 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 10/22 Gene Ontology BP GO:1902043 0.015717785777179 0.0559808131074437 2780 2068.45454545455 1875 0.00143920153454719 507 1.38975139692581 -1.38975139692581 -1 6.60442603118798 2780 3022 2777 2017 507 1875 4334 1276 1488 1715 962 1693 M13957 GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of glucose across a membrane. 6/22 Gene Ontology BP GO:1904659 0.131556965085471 0.228002608768885 785 2223.81818181818 1876 0.0140063145065231 583 0.598553450001734 0.648747668033277 1 1.4587669260515 782 1876 4165 2897 2650 824 583 1316 3689 3890 1790 1694 M14345 GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. 12/42 Gene Ontology BP GO:0055083 0.00903605825682858 0.0376913470869618 1880 1803.90909090909 1876 0.000824853352422863 280 1.07466858450262 -0.802911170417016 -1 5.80788576653585 2944 1119 1262 814 362 3243 2851 1876 280 1878 3214 1695 M11219 GO_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. 854/2124 Gene Ontology BP GO:0044281 0.0286055096648957 0.0833679666089529 3650 2158.63636363636 1877 0.00289805460548544 171 1.13552958950686 1.2588567025608 1 4.65079770669891 3647 171 3711 1151 752 351 3909 4577 1877 2137 1462 1696 M13180 GO_POSITIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_T_CELL_SELECTION.html The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. 11/30 Gene Ontology BP GO:0043368 0.0144944175287302 0.0529905048283087 1160 2018.81818181818 1877 0.00132643657678683 222 2.24458518468169 2.24458518468169 1 10.8699258708541 1157 4046 2106 3345 3616 2058 1877 381 222 1794 1605 1697 M16346 GO_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGIONALIZATION.html The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 132/438 Gene Ontology BP GO:0003002 0.004528494146988 0.0235187900721088 1385 1707.09090909091 1877 0.000412531143600091 486 1.33108783826358 1.39803229325592 1 8.22857029224448 1385 1998 486 1877 751 2957 2515 2020 1170 944 2675 1698 M13525 GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. 16/23 Gene Ontology BP GO:0006488 0.00280629986593679 0.0165982806083369 845 1934.54545454545 1878 0.000255444178377027 127 1.03465537491335 -1.03465537491335 -1 6.9904889767631 843 4098 3148 4175 3997 174 127 166 1878 2113 561 1699 M15960 GO_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REPOLARIZATION.html The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. 11/28 Gene Ontology BP GO:0086009 0.199268649250204 0.306460529469592 4285 2634.27272727273 1879 0.02 298 1.40606340631805 -1.42279293755586 -1 2.74131330201423 4283 298 1879 539 4549 4553 4582 1501 1703 779 4311 1700 M16610 GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. 16/23 Gene Ontology BP GO:0006490 0.00480838628452309 0.0245603273036751 845 1940.90909090909 1879 0.000438084355338536 128 1.03465537491335 -1.03465537491335 -1 6.32216256879222 844 4099 3149 4176 3998 175 128 216 1879 2124 562 1701 M12734 GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 16/45 Gene Ontology BP GO:0042036 0.00286037761164779 0.0167686025894958 3620 2133.81818181818 1880 0.000260373034277945 176 0.55096759559658 -0.449512612711664 -1 3.71325461883231 3618 1489 1062 1822 176 1730 2345 2571 1880 3561 3218 1702 M16307 GO_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS.html An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. 100/443 Gene Ontology BP GO:0006909 0.0251329417567393 0.0769743635283492 1265 2196.36363636364 1881 0.0023113399852366 692 1.29756054565144 1.46094656754172 1 5.48510698141914 1265 4188 692 3183 2507 3489 1278 1688 1881 1112 2877 1703 M13843 GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. 6/11 Gene Ontology BP GO:0002676 0.262784706650055 0.378563261860443 1340 1929.09090909091 1883 0.0300274732478362 861 1.48034281358945 1.48034281358945 1 2.37049726894077 1338 1252 4143 861 1948 2480 1883 2136 2614 1328 1237 1704 M15095 GO_RESPIRATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_DEVELOPMENT.html The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. 114/307 Gene Ontology BP GO:0060541 0.000209289129336262 0.00251743375002141 1885 1515.27272727273 1883 1.90280947237206e-05 23 1.40570187722083 1.51299892721509 1 13.8679971950898 1883 23 285 125 2026 4162 2014 2383 540 248 2979 1705 M13122 GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 13/35 Gene Ontology BP GO:0040036 0.0839184282471183 0.158445571591463 4460 2348.54545454545 1885 0.00793650793650794 325 1.19303539021459 1.09496894660095 1 3.62339455042091 4456 2123 1885 1476 1329 3839 4113 1325 325 879 4084 1706 M11953 GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. 10/21 Gene Ontology BP GO:0051560 0.257900105518284 0.373031211813518 1740 2372.45454545455 1886 0.0267512562691863 711 0.514202543574196 -0.550910869167716 -1 0.835879588561191 1739 1705 1886 3666 4460 711 3063 1377 3144 3379 967 1707 M15230 GO_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that modulates the frequency, rate or extent of membrane invagination. 12/29 Gene Ontology BP GO:1905153 0.0143792463197594 0.0527728071909633 890 1936.81818181818 1886 0.00131582713250034 622 1.9083122944764 1.9083122944764 1 9.25439679083814 890 2751 622 2590 3740 1670 922 1572 2387 1886 2275 1708 M15840 GO_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTION.html The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. 627/2036 Gene Ontology BP GO:0000003 0.0211684416878973 0.0682611593088426 1970 1971.63636363636 1887 0.00213728335976709 301 1.3558976387666 1.47451767519566 1 6.0002313931214 1967 2039 4465 1458 633 3156 1814 1887 1152 301 2816 1709 M13165 GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. 49/157 Gene Ontology BP GO:0055007 0.00106247564528564 0.00830040181453953 2715 2338.36363636364 1889 9.66353734693206e-05 381 1.79574690479717 1.94422285351084 1 14.1841642663454 2714 1889 381 1676 1133 4401 3682 4431 798 605 4012 1710 M13474 GO_RNA_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DESTABILIZATION.html Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. 8/23 Gene Ontology BP GO:0050779 0.0808645935013606 0.158445571591463 1635 2417 1889 0.00839673149646532 850 1.35593454827845 1.35593454827845 1 4.11813923818694 1635 3862 4083 4186 1850 1889 2304 850 3239 1517 1172 1711 M14727 GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. 59/151 Gene Ontology BP GO:1904064 0.0150111148096182 0.0542329468749027 4260 2156.45454545455 1889 0.00137404803440521 491 1.15140354261446 -1.10189111717827 -1 5.53194938911222 4257 2049 1537 1500 491 987 3217 3300 1889 1847 2647 1712 M15696 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. 12/30 Gene Ontology BP GO:0015012 0.161385165508919 0.258740097879113 3375 2067.72727272727 1889 0.0158730158730159 1180 1.1538764181133 -1.44204098723265 -1 2.57161193258017 3373 1180 2577 1432 3163 1772 2648 1542 1255 1889 1914 1713 M15925 GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. 12/30 Gene Ontology BP GO:1902170 0.0407516446342629 0.106178387226084 1485 2327.81818181818 1890 0.0037751528848994 398 0.477661433721462 0.566875825253984 1 1.76591688055293 1485 3689 749 3321 1890 1427 398 2949 3540 4380 1778 1714 M16149 GO_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. 418/971 Gene Ontology BP GO:0032386 0.0176854320859378 0.0608698748517488 4080 2176.36363636364 1891 0.00162083847466164 551 1.23903996352734 1.31870020395771 1 5.71718671722187 4080 1716 1559 2106 551 627 3926 3216 1891 1670 2598 1715 M13210 GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. 9/17 Gene Ontology BP GO:2000303 0.0597688255588382 0.138892220755598 1600 2351.45454545455 1893 0.00614399834456284 570 0.619046522679632 0.808804776325408 1 2.01453365630918 1598 570 4032 1827 4150 2934 1893 765 2732 3673 1692 1716 M15299 GO_RETINA_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_HOMEOSTASIS.html A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. 36/134 Gene Ontology BP GO:0001895 0.0259882738168489 0.0787621118352672 1895 1994.36363636364 1893 0.00239094949869249 654 1.60736109801448 1.85138572856988 1 6.73387264929472 1893 2101 697 1625 4153 3561 1899 3670 654 670 1015 1717 M13112 GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). 31/111 Gene Ontology BP GO:0007200 0.0248571507129172 0.0762442108805205 1670 2024 1895 0.00228568443851844 691 1.51430131785667 1.51430131785667 1 6.42511589744688 1667 1895 691 2003 712 2376 1818 4323 1788 2558 2433 1718 M13469 GO_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 21/70 Gene Ontology BP GO:0048708 0.232850105696956 0.342669743502683 2315 2168.45454545455 1895 0.0238095238095238 803 1.65735694990685 1.65735694990685 1 2.92612085012778 2314 803 1562 1054 1895 4574 3335 1680 1717 2327 2592 1719 M15445 GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. 5/20 Gene Ontology BP GO:0036148 0.0765897756730953 0.158445571591463 3460 2298 1896 0.00793650793650794 423 1.27675999939789 -1.27675999939789 -1 3.87767643941929 3457 1196 4406 1270 3158 2405 3997 1863 423 1207 1896 1720 M15790 GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT.html The progression of the atrioventricular valve over time, from its formation to the mature structure. 10/30 Gene Ontology BP GO:0003171 0.0839184282471183 0.158445571591463 2220 1911.27272727273 1897 0.00793650793650794 433 1.24967114279224 -0.791140711360448 -1 3.7954042652559 2217 1341 974 1488 4339 2047 2179 1897 433 1716 2393 1721 M10757 GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of an adaptive immune response. 77/220 Gene Ontology BP GO:0002819 0.216719772134653 0.326168525776724 725 2154.09090909091 1899 0.0219611511661401 723 1.29958242735532 1.29958242735532 1 2.40019006477054 723 3736 1806 4071 2816 1050 889 1234 2806 2665 1899 1722 M15674 GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune effector process. 246/673 Gene Ontology BP GO:0002697 0.0492199788246061 0.121042564450554 875 1747.63636363636 1899 0.00457790352432354 685 1.19033369192274 1.28256461744373 1 4.14356924017741 874 2406 1527 2938 1966 2095 831 685 1899 2264 1739 1723 M15695 GO_REGULATION_OF_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_COHESION.html Any process that modulates the frequency, rate or extent of sister chromatid cohesion. 11/21 Gene Ontology BP GO:0007063 0.0839184282471183 0.158445571591463 3385 2318.45454545455 1902 0.00793650793650794 595 1.53222578464289 -1.33403223803043 -1 4.65355730742476 3383 2466 1504 1555 4482 4196 1902 1285 595 776 3359 1724 M12752 GO_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. 53/141 Gene Ontology BP GO:0060070 0.085664162946073 0.160572752748735 3335 2143.18181818182 1905 0.00810852334948721 614 1.57245504476898 1.66409842843252 1 4.74116883973635 3331 614 875 1335 2843 1344 3048 4365 1905 1651 2264 1725 M13556 GO_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSPORT.html The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 165/504 Gene Ontology BP GO:0015711 0.000107054942336024 0.00152915200462122 890 1905.09090909091 1907 9.73274110251099e-06 257 1.42067796913439 1.46341049594488 1 15.1832946275258 888 1567 257 1386 2617 3468 2412 2137 1824 1907 2493 1726 M13852 GO_DICARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSPORT.html The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/107 Gene Ontology BP GO:0006835 0.0839184282471183 0.158445571591463 3250 1852.90909090909 1907 0.00793650793650794 156 2.13629216850644 2.13629216850644 1 6.4881808747079 2003 714 1169 456 3248 3679 3248 1907 156 1548 2254 1727 M13646 GO_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 265/645 Gene Ontology BP GO:0009314 0.0839184282471183 0.158445571591463 1910 2297.45454545455 1908 0.00793650793650794 1144 1.35069323914843 1.38616384964102 1 4.10222074063401 1908 3267 1144 3016 1499 3804 3243 1835 1234 1388 2934 1728 M11230 GO_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_VIRUS.html Reactions triggered in response to the presence of a virus that act to protect the cell or organism. 105/318 Gene Ontology BP GO:0051607 0.0839184282471183 0.158445571591463 2090 2239.81818181818 1909 0.00793650793650794 981 1.28152226669221 1.37823893835704 1 3.89214002826523 2088 1827 1909 2767 2801 4276 1905 981 1092 1739 3253 1729 M13437 GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. 12/44 Gene Ontology BP GO:0035116 0.078740267218618 0.158445571591463 3085 2315.36363636364 1909 0.00742802671762771 383 1.43984814673618 1.6234090287657 1 4.37299511075089 3085 1909 1573 1037 1446 4366 4022 2509 1245 383 3894 1730 M11863 GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. 20/49 Gene Ontology BP GO:0051058 0.197180087792424 0.30464402832216 505 2048.18181818182 1910 0.0197678976878781 502 1.19045135446987 1.19045135446987 1 2.33261493588444 502 3471 2329 2992 1910 1126 926 1795 3775 2285 1419 1731 M11147 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 12/37 Gene Ontology BP GO:0055012 0.0142677801173302 0.0526380793457477 1440 2359.54545454545 1911 0.00130556006248646 190 1.70820157422404 1.70820157422404 1 8.2911543916725 1437 3574 1624 3059 3408 1076 190 4320 3498 1858 1911 1732 M12654 GO_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. 79/246 Gene Ontology BP GO:0048469 0.137442167001694 0.236788119253754 1465 1951.45454545455 1911 0.0133512596408256 997 1.30371267128211 1.30371267128211 1 3.09609079978462 1463 2480 997 2104 2290 3074 1646 1911 1858 1727 1916 1733 M12610 GO_PROTEIN_HETEROTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTETRAMERIZATION.html The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. 23/43 Gene Ontology BP GO:0051290 0.173809498904623 0.274334942544153 750 1937.36363636364 1912 0.0172074942234859 749 0.425666994370613 -0.469957303875147 -1 0.907603627361127 749 2065 1918 2778 1819 1239 1912 1137 2662 3538 1494 1734 M16158 GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. 61/126 Gene Ontology BP GO:0046467 0.232850105696956 0.342669743502683 1635 2159.90909090909 1913 0.0238095238095238 903 0.957161284913418 -0.957161284913418 -1 1.68990125678947 1632 1831 2883 3019 2489 903 1505 1983 1913 4428 1173 1735 M13460 GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. 36/97 Gene Ontology BP GO:0042439 0.0386412928058985 0.102224539436006 3605 2168.90909090909 1914 0.00357610636874649 521 1.28812218568679 -1.02192717514728 -1 4.84277825821139 3603 521 1673 982 840 2698 4380 3802 529 1914 2916 1736 M15175 GO_LIPOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving liposaccharide. 52/115 Gene Ontology BP GO:1903509 0.0839184282471183 0.158445571591463 1915 2050.36363636364 1915 0.00793650793650794 56 1.32329013529197 1.44876578490595 1 4.01899415909469 4281 56 2469 586 2139 1915 1914 3094 712 1575 3813 1737 M15985 GO_RESPONSE_TO_FOLIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. 9/23 Gene Ontology BP GO:0051593 0.0460453039883522 0.115860574033061 2560 2313.54545454545 1916 0.00470281667686647 308 0.619156502602557 -0.415531443874845 -1 2.1999527987701 2560 1865 4491 1626 1806 3160 358 1916 308 4395 2964 1738 M16838 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 17/39 Gene Ontology BP GO:0045922 0.00889217801068976 0.037329459768203 1305 2234.18181818182 1916 0.000811665818263428 356 0.73426504557095 0.73426504557095 1 3.97990373505747 1303 1545 2651 1916 356 3096 1169 3029 3207 4606 1698 1739 M12288 GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING.html Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. 5/11 Gene Ontology BP GO:0006346 0.239185006336461 0.35032680896536 985 2141.63636363636 1918 0.0269662452879281 803 0.327647180134534 0.399417974333281 1 0.56653589742146 984 2986 3884 2617 1918 871 803 1648 3189 3457 1201 1740 M11122 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 11/27 Gene Ontology BP GO:0010875 0.0405246050077896 0.105799878598956 785 1692.27272727273 1920 0.00375371960843315 325 0.424825734824952 0.520936965575766 1 1.57308403910875 785 1977 2019 1920 2691 968 325 692 3248 3172 818 1741 M13518 GO_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_GROWTH.html The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. 39/100 Gene Ontology BP GO:0035265 0.0839184282471183 0.158445571591463 1815 2039.72727272727 1920 0.00793650793650794 652 1.66688708532377 1.66688708532377 1 5.06254016498757 1813 1017 1920 1303 3260 3126 3008 1662 652 2040 2636 1742 M16480 GO_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 160/439 Gene Ontology BP GO:0009615 0.0296185085457595 0.085422168770851 1640 1937.36363636364 1920 0.00272954025274744 539 1.16507061907074 1.28164217674937 1 4.72503809186898 1637 1920 843 3308 2221 3865 968 539 1223 2551 2236 1743 M10574 GO_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_PROCESS.html Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. 1040/2967 Gene Ontology BP GO:0002376 0.0674787860193579 0.151376816050765 1345 2076.09090909091 1922 0.00696199009002567 362 1.33619869996624 1.43813524206855 1 4.15872961541219 1344 2191 3606 1922 1367 4465 1800 2068 1210 362 2502 1744 M11944 GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION.html The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. 6/13 Gene Ontology BP GO:0017187 0.0765897756730953 0.158445571591463 4170 2357.36363636364 1922 0.00793650793650794 23 2.03378537143284 -1.54796415353554 -1 6.17685518147015 4167 838 3830 847 1724 3668 4397 1922 23 498 4017 1745 M15331 GO_FLAVONOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVONOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. 4/29 Gene Ontology BP GO:0009812 0.160962524189627 0.258740097879113 1775 2726.27272727273 1922 0.0173968865091871 842 0.531728254551018 -0.223816593805042 -1 1.18504781163582 1774 1819 4389 1554 1637 4411 3258 4142 1922 4241 842 1746 M15419 GO_HYDROGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_TRANSPORT.html The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 63/157 Gene Ontology BP GO:0006818 0.0648078847253257 0.146925297255707 1925 1778.45454545455 1923 0.0060726952789358 276 0.99195922533489 1.14699662432043 1 3.13614185201448 1923 376 3306 1810 2005 276 1405 2885 2293 2538 746 1747 M16481 GO_DEVELOPMENTAL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. 114/357 Gene Ontology BP GO:0021700 0.0226709691381038 0.0717775829362436 1365 1911.72727272727 1923 0.0020825472929409 677 1.23290318833122 1.19198209199634 1 5.35385335882683 1364 2196 677 1677 1967 3107 1910 1634 2111 1923 2463 1748 M10185 GO_ANTEROGRADE_AXONAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_AXONAL_TRANSPORT.html The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. 15/32 Gene Ontology BP GO:0008089 0.0270343427094689 0.080410283920605 430 1790.63636363636 1924 0.00248839816536133 428 0.802844411190204 -0.802844411190204 -1 3.33602377702024 1924 2026 3124 3099 1613 429 1135 515 2434 2970 428 1749 M11759 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 23/38 Gene Ontology BP GO:1903846 0.0597660986192562 0.138892220755598 2105 1859.54545454545 1926 0.00558675421209185 810 1.08918898596586 1.08918898596586 1 3.54449591428883 2102 1107 810 1349 1787 2031 1805 1926 1965 2388 3185 1750 M14088 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. 48/150 Gene Ontology BP GO:0045621 0.0565966574661101 0.134331474997554 3280 2289.27272727273 1926 0.0052824860729447 1018 1.53998267953229 1.53998267953229 1 5.09625322438017 3280 1926 1178 1981 1018 1838 3635 4625 1213 1461 3027 1751 M15110 GO_CATECHOLAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_TRANSPORT.html The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 2/17 Gene Ontology BP GO:0051937 0.0551656673215299 0.131620859904349 1930 2343.2 1926.5 0.00628523985574316 408 0.532713280784965 -0.532713280784965 -1 1.78080579143293 1929 1617 4355 NA 1924 1153 408 3441 3185 4186 1234 1752 M10527 GO_RESPONSE_TO_COLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COLD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. 30/78 Gene Ontology BP GO:0009409 0.00135767655879565 0.00969112621539502 1930 1895.09090909091 1927 0.000123501376409812 111 1.01215886140179 1.01215886140179 1 7.73632434241514 1927 1480 1357 1372 111 2998 1793 2546 2705 2540 2017 1753 M16439 GO_DOPAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_TRANSPORT.html The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 2/13 Gene Ontology BP GO:0015872 0.0551656673215299 0.131620859904349 1930 2395.7 1927.5 0.00628523985574316 409 0.532713280784965 -0.532713280784965 -1 1.78080579143293 1930 1618 4566 NA 1925 1154 409 3433 3186 4501 1235 1754 M10749 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. 6/29 Gene Ontology BP GO:0051150 0.115793236063839 0.205987737564906 3710 2493.27272727273 1928 0.0122310202934731 1287 1.70820157422404 1.70820157422404 1 4.44908681563122 3706 1556 3628 1574 1437 4345 2726 1287 1928 1306 3933 1755 M11127 GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of endothelial cell differentiation. 13/40 Gene Ontology BP GO:0045601 0.0489640375115033 0.120604788416928 1470 1689.36363636364 1928 0.0045535466360418 781 1.54796415353554 -1.54796415353554 -1 5.39773216048605 1466 2266 781 2123 2108 1699 897 1011 2072 1928 2232 1756 M15728 GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. 11/23 Gene Ontology BP GO:0016338 0.161385165508919 0.258740097879113 3255 2350.54545454545 1929 0.0158730158730159 527 1.72317199106608 1.72317199106608 1 3.84038497074051 3252 562 1146 527 4048 2555 1929 4597 1280 1813 4147 1757 M11243 GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of vacuolar transport. 13/23 Gene Ontology BP GO:1903337 0.0839184282471183 0.158445571591463 2905 2263.90909090909 1930 0.00793650793650794 557 1.69748649654937 1.69748649654937 1 5.15547432335012 2905 893 1473 1220 4489 4334 2628 1463 557 1930 3011 1758 M13905 GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a neurophysiological process. 14/34 Gene Ontology BP GO:0031646 0.0442481738817692 0.112572203470167 2310 1735.36363636364 1930 0.00410582031704364 659 1.9083122944764 1.9083122944764 1 6.87108831080316 724 2643 1930 2306 2885 2309 875 659 1367 2026 1365 1759 M11301 GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0033865 0.0242645169747324 0.0750087229736205 2605 2092.81818181818 1931 0.00223057681181647 177 1.82051220676583 1.82051220676583 1 7.77338536536527 2604 1396 2669 1252 651 4493 3391 1891 177 1931 2566 1760 M11912 GO_FOREBRAIN_GENERATION_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_GENERATION_OF_NEURONS.html The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. 24/114 Gene Ontology BP GO:0021872 0.0951328827426453 0.175348143935729 1370 1783.81818181818 1931 0.00904675487606561 402 1.21445333727057 1.27570675230677 1 3.48551236595266 1366 2633 1022 2854 2374 1931 1577 997 2266 402 2200 1761 M13040 GO_PROTEIN_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CARBOXYLATION.html The addition of a carboxy group to a protein amino acid. 6/13 Gene Ontology BP GO:0018214 0.0765897756730953 0.158445571591463 4170 2374.63636363636 1931 0.00793650793650794 24 2.03378537143284 -1.54796415353554 -1 6.17685518147015 4168 839 3998 848 1725 3669 4398 1931 24 503 4018 1762 M13708 GO_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. 301/698 Gene Ontology BP GO:0070925 0.000202923378010808 0.00246642210498476 4385 2210.27272727273 1931 1.84492816049311e-05 3 1.17784840495358 -0.988992602216694 -1 11.6598507608887 1790 4384 2927 4382 1931 3 1900 1430 2596 2891 79 1763 M10170 GO_HINDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). 79/247 Gene Ontology BP GO:0030902 0.161385165508919 0.258740097879113 3820 2474.36363636364 1932 0.0158730158730159 799 1.36536665616384 1.56609842797233 1 3.04295428024831 3816 3167 1047 1932 1917 2851 4086 1782 1600 799 4221 1764 M10373 GO_CARDIAC_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_DEVELOPMENT.html The progression of a cardiac septum over time, from its initial formation to the mature structure. 56/145 Gene Ontology BP GO:0003279 0.0571146560050937 0.135297626444719 1935 1914.63636363636 1933 0.00533215063599091 803 1.27400634188024 1.34109966161461 1 4.20100842907911 1933 1316 803 2135 1176 3035 1409 2077 2438 1749 2990 1765 M11148 GO_OXIDATIVE_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. 5/41 Gene Ontology BP GO:0070989 0.0248618856931096 0.0762442108805205 2305 1711.81818181818 1933 0.00251444969390163 56 2.01369544572059 2.01369544572059 1 8.54402387981592 2305 314 3699 591 2567 2814 2846 518 56 1187 1933 1766 M12343 GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. 31/66 Gene Ontology BP GO:1900024 0.0839184282471183 0.158445571591463 3360 2498.54545454545 1933 0.00793650793650794 718 1.35109154009017 1.35109154009017 1 4.10343042936044 3360 1933 1656 1082 4455 4055 4415 858 718 945 4007 1767 M15274 GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that activates or increases the frequency, rate or extent of blood circulation. 44/135 Gene Ontology BP GO:1903524 0.00136297769085784 0.00969112621539502 1085 1761.18181818182 1933 0.000123983894254301 400 1.23564681817399 1.25962065082781 1 9.444529828912 1084 2202 400 1933 2399 2306 1776 2543 2051 841 1838 1768 M12106 GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY.html The disaggregation of a beta-catenin destruction complex into its constituent components. 12/34 Gene Ontology BP GO:1904886 0.0625683746087926 0.143459241140061 970 2355.45454545455 1934 0.00585655193797826 737 0.364739180048816 0.386055185775959 1 1.16750044876435 968 3575 1831 3508 3894 1934 737 746 4121 3414 1182 1769 M14124 GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. 18/30 Gene Ontology BP GO:0032469 0.244993433944109 0.35781834344212 3075 2364.63636363636 1937 0.025224485203289 1169 1.09757480956824 1.3835610762205 1 1.85953621388833 3073 1169 1654 1176 1847 4623 1882 3232 1937 2203 3215 1770 M14342 GO_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASOCONSTRICTION.html Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. 35/92 Gene Ontology BP GO:0019229 0.19296659163488 0.299646784267809 500 1795.63636363636 1937 0.0193013168941869 499 1.38933387508025 1.38933387508025 1 2.76019389422155 499 2013 1763 1937 2461 1101 1593 2040 2043 2620 1682 1771 M10915 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. 192/441 Gene Ontology BP GO:0090316 0.00775718167632626 0.0341066236014989 4080 2314.36363636364 1938 0.000707697201779725 329 1.23983324557475 1.33627330960066 1 6.90475642978566 4079 1719 1902 1938 329 1550 4354 2698 2534 890 3465 1772 M12407 GO_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. 13/55 Gene Ontology BP GO:0050433 0.0147146434514024 0.0534168018333553 1440 1726.18181818182 1938 0.00134672668369521 385 1.29340131597999 -0.650112755713168 -1 6.24651239971129 1439 2569 2036 1460 1294 2312 2502 385 502 1938 2551 1773 M16037 GO_INACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INACTIVATION_OF_MAPK_ACTIVITY.html Any process that terminates the activity of the active enzyme MAP kinase. 18/28 Gene Ontology BP GO:0000188 0.152398415756278 0.254985889858162 2380 1985 1938 0.0149189193059819 1067 0.903622821473322 0.903622821473322 1 2.03565102466198 2379 1788 1486 1777 2758 1990 1108 1067 3332 2212 1938 1774 M12541 GO_ARACHIDONIC_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_SECRETION.html The controlled release of arachidonic acid from a cell or a tissue. 2/14 Gene Ontology BP GO:0050482 0.0748730668569442 0.158445571591463 2005 2199 1942 0.00860986826978592 469 0.301069185891026 -0.301069185891026 -1 0.914383979089807 2005 2548 3927 NA 1879 1097 469 1336 4006 3515 1208 1775 M13130 GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0033875 0.0242645169747324 0.0750087229736205 2610 2099.72727272727 1942 0.00223057681181647 179 1.82051220676583 1.82051220676583 1 7.77338536536527 2606 1398 2671 1254 653 4495 3393 1938 179 1942 2568 1776 M15723 GO_ARACHIDONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONATE_TRANSPORT.html The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 2/14 Gene Ontology BP GO:1903963 0.0748730668569442 0.158445571591463 2010 2335.2 1943 0.00860986826978592 470 0.301069185891026 -0.301069185891026 -1 0.914383979089807 2006 2549 4448 NA 1880 1098 470 1348 4007 4337 1209 1777 M13683 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. 13/18 Gene Ontology BP GO:1902165 0.0361298626424032 0.097303336571159 2055 1570.45454545455 1946 0.00333974747972977 218 2.31622896548935 2.31622896548935 1 8.89640227882121 2053 2856 2095 508 812 3052 2311 963 218 1946 461 1778 M16882 GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. 9/22 Gene Ontology BP GO:0000737 0.0347543423530802 0.0954254355679192 1225 2263.90909090909 1946 0.00353101550381921 306 0.308605999415179 -0.377068093606921 -1 1.1952389610166 1225 1946 4631 2787 4027 323 306 1149 3056 4619 834 1779 M11991 GO_RESPONSE_TO_METHYLMERCURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METHYLMERCURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. 5/14 Gene Ontology BP GO:0051597 0.275742742869669 0.392721949430635 1830 2141.27272727273 1948 0.0317460317460317 908 0.58198297025918 -0.645583269273137 -1 0.896710842253085 1826 908 3839 1487 2463 1337 2317 2379 1948 3389 1661 1780 M12620 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/44 Gene Ontology BP GO:0034032 0.0242645169747324 0.0750087229736205 2605 2099.54545454545 1948 0.00223057681181647 178 1.82051220676583 1.82051220676583 1 7.77338536536527 2605 1397 2670 1253 652 4494 3392 1948 178 1939 2567 1781 M15027 GO_SCHWANN_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DEVELOPMENT.html The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 18/34 Gene Ontology BP GO:0014044 0.0581675184925519 0.136676006255525 1260 2451 1949 0.00543317327169862 1039 0.305427116847882 0.342944332542962 1 1.00203574862544 1258 3503 2845 3978 1039 1639 1477 1473 3642 4158 1949 1782 M15894 GO_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. 23/67 Gene Ontology BP GO:0048806 0.221537356990644 0.33266427830128 1910 2143.45454545455 1949 0.0225095453625403 714 1.37091145355478 1.5200039889936 1 2.48736161454079 1907 3004 1122 1889 3810 2875 1091 1949 2829 714 2388 1783 M14231 GO_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/57 Gene Ontology BP GO:0032371 0.0833572470763782 0.158445571591463 870 2006.72727272727 1950 0.00788127542039085 663 0.400325231087823 0.543162955610355 1 1.21583674086855 869 2164 2103 3396 1950 1573 1023 836 3544 3953 663 1784 M15298 GO_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 21/57 Gene Ontology BP GO:0032374 0.0981253856233584 0.179935294411237 870 2037.54545454545 1951 0.0093451309408653 664 0.400325231087823 0.543162955610355 1 1.13190148740708 870 2165 2104 3397 1951 1574 1024 888 3545 4231 664 1785 M13023 GO_VITAMIN_D_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). 3/25 Gene Ontology BP GO:0042359 0.018798191538748 0.0633841708891843 735 2006.27272727273 1952 0.00189591283119773 225 0.459171660517881 0.459171660517881 1 2.08807493632365 735 1952 3995 1995 3576 812 225 968 3275 3627 909 1786 M16018 GO_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. 131/386 Gene Ontology BP GO:0042692 5.09919551334239e-06 0.00013314768774971 1955 2218.54545454545 1953 4.63564302943493e-07 166 1.59042156257677 1.62975997038263 1 23.3973068553463 1953 1307 166 1287 2475 4478 2437 3819 1848 939 3695 1787 M12295 GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. 49/122 Gene Ontology BP GO:0032091 0.00707344998573528 0.0317007995017074 4565 2226.72727272727 1956 0.000645117770427055 314 1.04832394349031 1.18705667517329 1 5.96463710063967 4565 1475 1685 1404 314 1071 3896 1956 2646 2314 3168 1788 M14471 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 34/81 Gene Ontology BP GO:0090280 0.00271022983083802 0.0162578773960994 1840 2196.36363636364 1956 0.000246688581283473 170 1.50339326058164 1.88352542766232 1 10.2087994374558 3091 2621 1217 1956 170 3280 3435 1839 708 1839 4004 1789 M15242 GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. 13/29 Gene Ontology BP GO:2000178 0.0462736860419848 0.115946424335097 2365 2118.90909090909 1957 0.00429787679122962 668 1.15754870530989 1.15754870530989 1 4.1115248977119 2364 1445 1664 1727 1372 3044 3270 668 3386 1957 2411 1790 M13342 GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. 8/24 Gene Ontology BP GO:0031272 0.0461331942467529 0.115860574033061 1905 2439.72727272727 1958 0.00471198698170031 380 0.495743041321406 0.703962625383348 1 1.76144688236291 1902 3366 4055 3080 4030 1917 1747 690 380 3712 1958 1791 M11916 GO_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CHEMOTAXIS.html The movement of a leukocyte in response to an external stimulus. 52/167 Gene Ontology BP GO:0030595 3.43313893346054e-05 0.000622658752658488 2065 1793.81818181818 1959 3.12108409942877e-06 219 1.3406138131431 1.3406138131431 1 16.3132525136288 726 2839 219 1959 3101 2622 1741 2063 825 1574 2063 1792 M11551 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. 22/70 Gene Ontology BP GO:0003333 0.210150919307057 0.319179168577908 1885 2229.54545454545 1960 0.0212183271749212 1262 1.4836078808557 1.4836078808557 1 2.79304411894147 1884 1643 1904 1978 1751 4642 2861 2459 1960 1262 2181 1793 M14315 GO_NON_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_RECOMBINATIONAL_REPAIR.html A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. 41/88 Gene Ontology BP GO:0000726 0.0961730891264001 0.176844218936188 325 2137.45454545455 1961 0.00915036977949715 325 0.329269520438736 -0.357611908985919 -1 0.940400433239242 325 3530 2907 4177 1961 432 1026 999 3263 3979 913 1794 M11081 GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY.html The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. 15/35 Gene Ontology BP GO:0007250 0.0839184282471183 0.158445571591463 1795 2121.63636363636 1962 0.00793650793650794 277 3.21934379747048 3.21934379747048 1 9.77754127641277 1795 4508 1360 1962 3652 3149 2487 1085 277 2062 1001 1795 M12703 GO_CELLULAR_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. 36/154 Gene Ontology BP GO:0034754 0.0839184282471183 0.158445571591463 1915 2034.27272727273 1962 0.00793650793650794 663 0.972697346968767 -0.947040535988886 -1 2.95420093576819 1912 1962 2181 1977 1373 2581 663 4042 810 1913 2963 1796 M10964 GO_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of dendrite morphogenesis. 46/125 Gene Ontology BP GO:0048814 0.194926470336958 0.301882455561873 745 1855.90909090909 1963 0.0195180675725935 741 1.61156951470423 1.61156951470423 1 3.18196209436864 741 2997 2240 3400 1963 1215 996 1460 2382 2223 798 1797 M16914 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. 8/23 Gene Ontology BP GO:2000651 0.348407611487045 0.471548427771505 1535 2656.09090909091 1963 0.0419292082197036 925 0.455622679123296 -0.537932544889474 -1 0.564625858661118 1534 1452 4636 1963 4439 925 1277 3627 3240 4629 1495 1798 M11834 GO_ERBB2_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB2_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. 26/61 Gene Ontology BP GO:0038128 0.0658607535288314 0.148511578483783 1665 2065.09090909091 1964 0.00617447416807978 1099 1.21455215107271 1.21455215107271 1 3.81838253442214 1665 2161 1925 2491 1099 1964 1351 3394 2694 2464 1508 1799 M10225 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. 9/34 Gene Ontology BP GO:2000678 0.0765897756730953 0.158445571591463 1110 1913.63636363636 1967 0.00793650793650794 577 1.70820157422404 1.70820157422404 1 5.18801732615965 1108 2718 3556 1967 2182 1224 675 3223 577 1578 2242 1800 M16917 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. 13/64 Gene Ontology BP GO:0045620 0.0127793855775247 0.0485951574418079 175 1469.63636363636 1969 0.001168566179682 125 1.03190356104762 1.03190356104762 1 5.14452960741699 174 2121 2008 2442 3799 125 175 473 2653 1969 227 1801 M16615 GO_RESPONSE_TO_LEAD_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEAD_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. 13/30 Gene Ontology BP GO:0010288 0.19796216556432 0.305361572995062 820 2296.36363636364 1970 0.0198547458087626 820 0.507154711951685 0.501505623417491 1 0.991771044903973 1600 820 1970 1861 1717 2970 820 3351 3202 4545 2404 1802 M16833 GO_CARDIAC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. 37/93 Gene Ontology BP GO:0055006 0.000917604786746951 0.00765212956885139 4135 2448.09090909091 1970 8.34534306357348e-05 371 1.83034439351975 -1.57303298172666 -1 14.7028113124152 4133 1477 371 1407 1970 3055 4265 4031 1449 690 4081 1803 M13109 GO_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ADAPTATION.html A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 22/50 Gene Ontology BP GO:0043500 0.0085889787976005 0.0365431175769339 2360 2003.36363636364 1971 0.000783881390741472 559 1.70820157422404 1.70820157422404 1 9.31884024487364 1270 1484 559 1470 3372 1971 1436 3761 1997 2357 2360 1804 M15111 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. 5/14 Gene Ontology BP GO:0033033 0.0171364617469194 0.0595989452366644 2060 1960 1972 0.00172700602467687 50 2.24458518468169 2.24458518468169 1 10.4350569340723 2056 3265 4356 1972 4467 2053 1389 429 50 1205 318 1805 M11578 GO_ADULT_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_LOCOMOTORY_BEHAVIOR.html Locomotory behavior in a fully developed and mature organism. 40/161 Gene Ontology BP GO:0008344 0.0273632702023127 0.0809736542698137 1975 2006.63636363636 1973 0.00251905975590582 519 1.3723056912969 1.3723056912969 1 5.68648640839989 1973 3275 1765 2167 1673 3354 2684 519 821 1213 2629 1806 M15071 GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. 6/23 Gene Ontology BP GO:0046321 0.150793183391114 0.252878153231517 1345 2473 1977 0.016212393429158 1288 0.475649742385777 0.6444149944258 1 1.07803619100972 1343 2691 4343 3051 1589 1823 1774 1288 3152 4172 1977 1807 M11747 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion. 8/14 Gene Ontology BP GO:2000484 0.123866825585093 0.217269992894441 1980 1948.27272727273 1978 0.0131366681775513 980 1.46584243959724 1.46584243959724 1 3.68899625643432 1978 980 3799 2177 1473 2276 1009 1867 2079 1505 2288 1808 M14875 GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune effector process. 89/270 Gene Ontology BP GO:0002699 0.0469191089589434 0.117121195105578 1900 2049.09090909091 1979 0.00435915287399666 941 1.29270853026874 1.44965942123308 1 4.57011920508556 1899 2770 1130 2565 941 2997 1643 1185 2301 1979 3130 1809 M11997 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. 265/608 Gene Ontology BP GO:0032388 0.00865770890231602 0.0366767722932968 3140 2173.09090909091 1980 0.000790178970764531 351 1.24285461257689 1.39749513443638 1 6.77272900782994 3137 1757 1671 1545 351 1980 3607 1985 2399 907 4565 1810 M14656 GO_ENDOCYTIC_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_RECYCLING.html The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. 13/29 Gene Ontology BP GO:0032456 0.00544008147036114 0.0265318259105954 1640 2013.63636363636 1981 0.000495780023989269 269 1.69748649654937 1.69748649654937 1 10.1562629540272 1638 3148 2354 2940 269 1410 2424 2267 1981 1955 1764 1811 M10827 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. 49/123 Gene Ontology BP GO:1903428 0.131707616862937 0.228178531751723 2355 2200.09090909091 1983 0.0127567318679276 934 1.20016987054401 1.27031135992548 1 2.92347280071179 2354 1577 1944 934 2261 4618 2973 1003 1983 1482 3072 1812 M11582 GO_RESPONSE_TO_GRAVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GRAVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. 6/20 Gene Ontology BP GO:0009629 0.00022574387809343 0.00266862170881668 1985 2040.54545454545 1983 2.25766813506923e-05 29 2.51960658933014 2.51960658933014 1 24.6150136116318 1983 3162 3772 1159 3560 3410 2536 40 29 1311 1484 1813 M10562 GO_REGULATION_OF_PODOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PODOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of podosome assembly. 9/27 Gene Ontology BP GO:0071801 0.0343648318024285 0.0945782144473027 1060 2187.27272727273 1985 0.00349081177785506 604 0.997293395573521 0.997293395573521 1 3.87720456061456 1059 3610 3603 2413 4462 1739 630 604 1985 3047 908 1814 M13357 GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS.html A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 11/28 Gene Ontology BP GO:0097067 0.00346074102814473 0.0193360055278893 1080 1960.18181818182 1985 0.000315108819552689 463 0.676645974513058 0.750061720146729 1 4.4013571487169 1080 2315 463 1521 1985 1330 918 2813 3426 3715 1996 1815 M14054 GO_VITAMIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORT.html The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 15/42 Gene Ontology BP GO:0051180 0.0330861764716838 0.0924859225514919 1890 2189.90909090909 1985 0.00305404550817747 728 0.587887798897698 0.547887990455654 1 2.30722765476193 770 2568 728 2718 3938 1888 1886 1538 2162 3908 1985 1816 M12092 GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving guanosine-containing compounds (guanosines). 24/59 Gene Ontology BP GO:1901068 0.0729097464096189 0.158445571591463 1345 2002.36363636364 1986 0.00685858609149119 506 0.714092449815773 -0.686007751272719 -1 2.16878620055775 1342 2740 3227 2401 1150 506 1134 1986 3329 3409 802 1817 M14920 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 12/24 Gene Ontology BP GO:0042347 4.18830040112678e-05 0.000725607416508643 4370 2110.63636363636 1988 3.80761830816403e-06 15 1.00040350070618 -0.644872453133905 -1 11.9210639273368 4369 823 2790 1087 15 1988 3905 913 2155 1884 3288 1818 M11217 GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. 38/75 Gene Ontology BP GO:0070228 0.124947268291748 0.218770275577925 1625 2423.72727272727 1989 0.0120604220815518 970 1.66432443968961 1.66432443968961 1 4.16962354937691 1621 4165 970 3981 3817 2048 1532 1376 3228 1989 1934 1819 M14476 GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a cardiac muscle cell. 24/74 Gene Ontology BP GO:0086001 0.415320710913563 0.535202348257472 850 2079 1989 0.0476190476190476 750 1.47343464504073 1.49875549878316 1 1.51837530525717 849 2295 1604 2371 4474 1853 2407 1910 2367 750 1989 1820 M16172 GO_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_IMPORT.html The directed movement of amino acids into a cell or organelle. 7/29 Gene Ontology BP GO:0043090 0.0144995831321679 0.0529905048283087 1215 2085.54545454545 1991 0.00145950682126585 509 0.61480658630684 0.603488889067815 1 2.9773439045164 1212 1991 4523 2248 509 2374 1262 849 2649 4433 891 1821 M14538 GO_CARDIOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. 58/192 Gene Ontology BP GO:0035051 1.71045898307083e-05 0.000372847937013983 2225 2146.36363636364 1992 1.55497480155934e-06 190 1.79574690479717 1.94422285351084 1 23.3696651812007 2225 1574 190 1333 1992 4378 3296 3392 871 762 3597 1822 M13099 GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 9/22 Gene Ontology BP GO:0009068 0.00307446968457306 0.0178028555730113 3365 2135.81818181818 1993 0.000307873154919415 194 0.907956294871668 -1.23889395501682 -1 6.02960255759301 3363 658 4012 1155 194 4354 3537 431 2195 1602 1993 1823 M14205 GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a myeloid leukocyte. 24/91 Gene Ontology BP GO:0002444 0.0438834476926795 0.112051654492429 1360 2158.81818181818 1993 0.00407127676441395 908 0.465572845182058 0.598227427652414 1 1.67990349765079 1360 1965 1993 2780 908 3013 2051 1153 2768 3944 1812 1824 M11547 GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 342/771 Gene Ontology BP GO:0010638 0.0607170165442283 0.140721239830686 3480 2322.09090909091 1994 0.00567822471684271 1059 1.15766973435923 1.33957160854356 1 3.7423821997418 3476 1717 1994 1803 1059 1342 3952 2475 1875 2093 3757 1825 M13311 GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 16/23 Gene Ontology BP GO:0035729 0.0174142932264141 0.0602942307608058 1720 2180.63636363636 1997 0.00159578952496163 416 0.653874098340854 0.653874098340854 1 3.02735269518798 1716 1792 2089 1842 3141 2142 1823 416 3325 3704 1997 1826 M10235 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that activates or increases the rate of gene expression. 48/111 Gene Ontology BP GO:0045815 0.0354219227958976 0.0962340477129039 2000 2292.63636363636 1998 0.00327322210359136 586 1.33403223803043 -1.33403223803043 -1 5.14818443301924 1998 4362 1676 4268 1862 1201 2646 586 2290 2733 1597 1827 M10815 GO_PROTEIN_LOCALIZATION_TO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CILIUM.html A process in which a protein is transported to, or maintained in, a location within a cilium. 14/32 Gene Ontology BP GO:0061512 0.232850105696956 0.342669743502683 3045 2080.54545454545 1998 0.0238095238095238 910 1.22774045916099 1.59491418036229 1 2.16761812005695 3042 967 2401 1245 4076 943 1998 3424 1660 910 2220 1828 M13705 GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 16/23 Gene Ontology BP GO:0035728 0.0153870089810587 0.0549976002302199 1720 2189 1998 0.00140869935346641 391 0.653874098340854 0.653874098340854 1 3.12646387208457 1717 1793 2090 1843 3142 2143 1824 391 3326 3812 1998 1829 M15004 GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. 38/80 Gene Ontology BP GO:0043666 0.0839184282471183 0.158445571591463 3060 2253.54545454545 1998 0.00793650793650794 604 2.18771116543902 2.18771116543902 1 6.64434666392995 3059 1371 1690 1414 1439 2912 3900 2641 604 1998 3761 1830 M11414 GO_DNA_INTEGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRATION.html The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. 2/7 Gene Ontology BP GO:0015074 0.108098946905923 0.194310263447233 1710 2132.1 1999 0.0126306748777942 552 0.338190206523036 -0.338190206523036 -1 0.913367937519051 1706 2190 3741 NA 2345 1204 552 1723 2807 3245 1808 1831 M16925 GO_DIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 112/346 Gene Ontology BP GO:0072511 0.00953809694534652 0.0392592104060817 1440 2015 1999 0.000870882009293347 567 1.33693264420649 1.40110656142499 1 7.13542967477157 1438 1999 567 2862 2294 3874 2257 1582 1193 1905 2194 1832 M15335 GO_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERTILIZATION.html The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). 57/221 Gene Ontology BP GO:0009566 0.0839184282471183 0.158445571591463 4435 2411.63636363636 2001 0.00793650793650794 753 1.76274762592298 2.07229271977465 1 5.35368036357134 4435 2772 1308 2001 4049 1243 3155 1628 753 1767 3417 1833 M10116 GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of hepatocyte proliferation. 6/16 Gene Ontology BP GO:2000345 0.0135052379274941 0.0505684029817379 2005 1907.36363636364 2002 0.00135880230509805 386 1.48034281358945 1.48034281358945 1 7.28307862037656 2002 1668 3536 999 2297 2200 2206 386 2811 1301 1575 1834 M11860 GO_PEPTIDYL_PROLINE_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_HYDROXYLATION.html The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. 8/13 Gene Ontology BP GO:0019511 0.0104179006938295 0.0417015156251411 2845 2379.72727272727 2002 0.00104670650868624 359 1.8636644772713 1.8636644772713 1 9.76126846442552 2844 3364 3817 1459 429 4630 4551 1214 359 1508 2002 1835 M11936 GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 48/142 Gene Ontology BP GO:0019217 0.264125764169855 0.380141327662937 1365 2582.63636363636 2002 0.0274963585730221 1363 0.692037644314168 -0.649810243057386 -1 1.1034255059842 1363 2916 2002 3611 1893 4160 1574 1697 3875 3376 1942 1836 M12725 GO_RESPONSE_TO_INSULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSULIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 111/299 Gene Ontology BP GO:0032868 0.0722943463129572 0.158445571591463 2455 2107.90909090909 2003 0.00679867283171123 426 1.34404797583734 1.43657611163596 1 4.08203826233858 2454 860 852 426 1143 4614 3295 2804 2003 955 3781 1837 M12473 GO_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BUDDING.html The evagination of a membrane, resulting in formation of a vesicle. 82/170 Gene Ontology BP GO:0006900 0.00533840272272662 0.0262207873196285 3670 2305.90909090909 2004 0.000486490980386309 266 1.15399425547617 1.24836586100728 1 6.92691812173659 3670 1147 2564 1987 266 1711 3610 2126 2004 1770 4510 1838 M12871 GO_PROTEIN_LOCALIZATION_TO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMATIN.html Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. 12/19 Gene Ontology BP GO:0071168 0.308201125945773 0.424748538962963 1585 2357.09090909091 2004 0.032941573081555 1058 1.33403223803043 -1.33403223803043 -1 1.88305275855425 1585 3149 1632 3624 3195 1394 2803 2004 3611 1873 1058 1839 M10613 GO_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 100/221 Gene Ontology BP GO:0051783 0.0405673749697618 0.105817034822811 2785 1976.09090909091 2005 0.00375775687894445 867 1.51346680803906 1.79917906339406 1 5.60380039104017 2784 2284 1201 1873 867 1081 2934 3359 2238 1111 2005 1840 M11888 GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS.html Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. 19/50 Gene Ontology BP GO:0044068 0.0271610219559724 0.0805416636788611 3830 2190.09090909091 2009 0.00250020569200301 640 1.84601786585865 1.84601786585865 1 7.66570807699495 3828 640 1694 1044 698 2077 4610 2009 2325 1120 4046 1841 M16274 GO_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 27/68 Gene Ontology BP GO:0051489 0.122378293893877 0.215146693884615 3025 2511 2009 0.0117971017459216 964 1.04582496955364 0.809062022992761 1 2.64889530435924 3022 1730 964 1656 2009 4142 3714 1436 2924 1479 4545 1842 M12354 GO_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMOPOIESIS.html Any process that modulates the frequency, rate or extent of hemopoiesis. 187/511 Gene Ontology BP GO:1903706 0.0105849036649973 0.0421524779061748 1695 2180.18181818182 2011 0.000966925156709899 577 1.58023504775979 1.58023504775979 1 8.24873755854319 1691 2613 577 1961 3013 4171 2011 2395 1041 1365 3144 1843 M15553 GO_GMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GMP, guanosine monophosphate. 9/27 Gene Ontology BP GO:0046037 0.0477409531581497 0.118725894758055 2020 2147 2012 0.00487987186575465 555 0.307147712619037 -0.354178995584384 -1 1.07897059923484 2020 2686 4420 2012 986 555 853 1558 3570 4302 655 1844 M15988 GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 40/141 Gene Ontology BP GO:0030801 0.000846033451222776 0.00720759392184843 2390 2244.36363636364 2012 7.69417252433529e-05 362 1.22743231134374 -1.29245240179828 -1 9.98083238079892 2388 2012 362 1960 1727 4537 1500 2815 2584 1219 3584 1845 M13785 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK.html The synchronization of a circadian rhythm to environmental time cues such as light. 17/73 Gene Ontology BP GO:0009649 0.0862160822528716 0.161281736462564 2360 2283.54545454545 2014 0.00816296866354276 1247 0.849254971022537 0.849254971022537 1 2.55445297467547 2356 1389 1606 2014 1247 1996 1681 2817 3470 3833 2710 1846 M15892 GO_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. 73/178 Gene Ontology BP GO:0007498 0.0839184282471183 0.158445571591463 2775 2496.63636363636 2014 0.00793650793650794 702 1.40750926808264 1.4780174193951 1 4.27477797683617 2771 1679 1041 1586 2014 4408 3413 4541 1018 702 4290 1847 M16964 GO_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a higher concentration of a chemical. 24/52 Gene Ontology BP GO:0050918 0.492716437922596 0.610048645673231 995 2283.72727272727 2014 0.059833835769114 992 1.46584243959724 1.46584243959724 1 1.19425245568808 992 3808 1408 3713 3066 1485 1591 2014 2971 2425 1648 1848 M15534 GO_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERAD_PATHWAY.html The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. 44/99 Gene Ontology BP GO:0036503 0.000771498496564793 0.00683600671669911 885 1990.90909090909 2015 7.01608344941016e-05 13 0.522536967759313 0.522536967759313 1 4.29459063431738 885 2344 3251 2884 2015 13 751 1339 4016 4298 104 1849 M16538 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. 43/230 Gene Ontology BP GO:0007187 0.0850148440887422 0.159871981006088 1065 1844.27272727273 2016 0.00804450807698706 948 1.1866416600189 1.1866416600189 1 3.58644416304834 1064 2097 966 2652 1233 2016 948 3149 2276 2695 1191 1850 M16930 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 30/86 Gene Ontology BP GO:0045980 0.0839184282471183 0.158445571591463 4170 2517 2016 0.00793650793650794 1221 1.26417939172274 -1.01405746558881 -1 3.83946759359021 4169 2016 1574 2300 1997 3249 3619 1939 1221 1649 3954 1851 M11379 GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY.html The initiation of the activity of the inactive enzyme JUN kinase (JNK). 17/58 Gene Ontology BP GO:0007257 0.0225091690939404 0.0714354559830249 390 1686.54545454545 2017 0.00206752946617561 201 1.46584243959724 1.46584243959724 1 6.37693217171998 387 2673 2622 3085 4115 201 237 675 2017 2143 397 1852 M16202 GO_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 72/242 Gene Ontology BP GO:0044070 0.0137417732950113 0.0512474324568171 1980 2347.36363636364 2019 0.00125712419811475 368 1.33030957257948 1.66301187566353 1 6.5156842637765 1976 1886 1712 1469 2618 4406 3535 368 2019 2635 3197 1853 M15853 GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION.html A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. 195/501 Gene Ontology BP GO:0023014 0.0839184282471183 0.158445571591463 2760 2236.72727272727 2020 0.00793650793650794 598 1.5221043805667 1.6072538081315 1 4.62281736402083 2759 598 2305 1050 1448 3844 2020 3145 1104 1976 4355 1854 M14500 GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. 35/83 Gene Ontology BP GO:1901292 0.00996966967991659 0.0404979670374915 4200 2258.81818181818 2021 0.000910467058195318 382 1.1365216668259 -0.794526396855928 -1 6.00759961284125 4196 1098 2021 1806 382 2331 3767 2237 1884 1899 3226 1855 M11161 GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL.html Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 4/21 Gene Ontology BP GO:0045760 0.275742742869669 0.392721949430635 1815 2302.72727272727 2022 0.0317460317460317 1090 1.13975148755868 -1.13975148755868 -1 1.75611240997566 1811 3616 3700 2866 3529 1188 2196 2022 1980 1090 1332 1856 M15943 GO_REGULATION_OF_CELL_SHAPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SHAPE.html Any process that modulates the surface configuration of a cell. 82/204 Gene Ontology BP GO:0008360 0.0419217107592135 0.108496378514508 2995 2281 2022 0.00388568409855626 753 1.24447721629933 1.45719928974899 1 4.55653358916234 2995 2376 753 1070 2022 3433 3918 926 1906 1771 3921 1857 M11562 GO_DNA_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEALKYLATION.html The removal of an alkyl group from one or more nucleotides within an DNA molecule. 7/20 Gene Ontology BP GO:0035510 0.241218113618372 0.352780217512473 2255 2212.18181818182 2023 0.0272265799283242 978 0.55936453995665 -0.55936453995665 -1 0.960763935104276 2253 1811 3770 2393 1887 1108 2023 1989 2833 3289 978 1858 M13940 GO_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell. 225/577 Gene Ontology BP GO:0040007 0.0315566877751797 0.089296043329941 2025 2013 2023 0.00291078536794755 720 1.5026136491546 1.54842288973246 1 5.98410915974594 2023 2088 720 1047 2364 4279 2868 1702 904 763 3385 1859 M10260 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. 61/134 Gene Ontology BP GO:0002504 0.173281534664024 0.274047850792458 1770 2438.54545454545 2026 0.0171504164077253 532 1.04199361456204 -0.708329498464269 -1 2.22352867864363 1769 4059 2011 4117 3232 532 2026 1574 3580 2797 1127 1860 M11409 GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. 892/2411 Gene Ontology BP GO:0009891 0.0458233258652297 0.115818019592957 1430 2116 2026 0.00467965928053996 972 1.29821232365602 1.37787306863182 1 4.61352274612741 1429 2085 3739 2151 972 4342 1387 1490 2102 1553 2026 1861 M11470 GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 15/27 Gene Ontology BP GO:0009067 0.166825628901443 0.266084299206252 1060 1958.72727272727 2026 0.0164551403786039 793 1.23889395501682 -1.23889395501682 -1 2.7039251838091 1056 3329 2619 3025 3250 793 1298 1119 2026 2066 965 1862 M15120 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. 61/134 Gene Ontology BP GO:0002495 0.173281534664024 0.274047850792458 1770 2448.27272727273 2027 0.0171504164077253 533 1.04199361456204 -0.708329498464269 -1 2.22352867864363 1770 4060 2012 4118 3233 533 2027 1668 3581 2801 1128 1863 M13622 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 4/15 Gene Ontology BP GO:0010867 0.147859119791321 0.249186894080256 1700 2300.18181818182 2028 0.0158730158730159 1099 1.90919498657043 1.90919498657043 1 4.37337439532391 1699 3675 4107 1820 2028 3361 2954 1258 1242 1099 2059 1864 M10349 GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION.html A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. 46/78 Gene Ontology BP GO:0061572 0.0839184282471183 0.158445571591463 2210 2096.90909090909 2030 0.00793650793650794 738 1.053516088091 1.06627022522928 1 3.19965734768217 2210 1890 2030 738 1688 4564 2745 1410 1011 2715 2065 1865 M11055 GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. 13/34 Gene Ontology BP GO:0002042 0.138135768013224 0.237806589130664 825 1678.45454545455 2030 0.0134234119385699 672 1.20313380481586 1.20313380481586 1 2.84872090426015 821 2267 1303 2030 2248 2127 1300 2150 2674 871 672 1866 M15041 GO_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXPLORATION_BEHAVIOR.html The specific behavior of an organism in response to a novel environment or stimulus. 14/41 Gene Ontology BP GO:0035640 0.146918903023911 0.249186894080256 1955 2029.36363636364 2030 0.014341678989416 590 1.72130338621463 1.72130338621463 1 3.94297293297678 1951 2972 2170 2628 2790 782 590 4068 1522 2030 820 1867 M11169 GO_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORT.html A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 78/301 Gene Ontology BP GO:0098656 0.0839184282471183 0.158445571591463 2390 2242.90909090909 2031 0.00793650793650794 864 1.85275549562683 1.85275549562683 1 5.6270452840681 2390 864 1133 2031 1596 2964 3334 4530 873 1655 3302 1868 M16952 GO_POSITIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSSIFICATION.html Any process that activates or increases the frequency, rate or extent of bone formation. 57/117 Gene Ontology BP GO:0045778 0.0237360755323411 0.0740220057953015 3385 2353 2031 0.00218146393340489 478 1.46731223806678 1.49845319841996 1 6.29729140550926 3381 1519 681 884 2031 4146 3517 4132 632 478 4482 1869 M10937 GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that activates or increases the activity of a transporter. 42/118 Gene Ontology BP GO:0032411 0.291859055223256 0.410139707445999 1895 2211.36363636364 2033 0.0308867782934744 806 1.06094041096732 -0.941440206989479 -1 1.55878312784791 2729 1892 2033 1711 1968 806 2839 4210 2120 2125 1892 1870 M11134 GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. 96/294 Gene Ontology BP GO:0051146 0.00216181452819626 0.0138254887801863 2035 2364.18181818182 2034 0.000196721977002745 427 1.658509990124 1.69270079348294 1 11.705213738762 2034 1569 427 1708 2660 4638 3076 4187 1093 1049 3565 1871 M14245 GO_SMALL_MOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. 178/427 Gene Ontology BP GO:0044282 0.0287183472229194 0.0835459186441196 3010 1892.72727272727 2034 0.00264547528281829 8 1.08652157011976 -0.859642644445426 -1 4.44625598235414 3006 8 889 712 720 1062 4139 3178 2408 2664 2034 1872 M16768 GO_MULTI_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_BEHAVIOR.html Any process in which an organism has a behavioral effect on another organism of the same or different species. 23/106 Gene Ontology BP GO:0051705 0.0574905395868426 0.135565553733728 4150 2112.36363636364 2035 0.00536820506118461 362 1.79129010967752 -1.51935086267539 -1 5.90089858818753 4147 2064 2035 362 1030 2384 1903 4049 452 1298 3512 1873 M13786 GO_REGULATION_OF_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. 19/38 Gene Ontology BP GO:0030823 0.0997971223688741 0.182137594008916 3440 2224.72727272727 2036 0.00951220830478099 598 1.3502490810646 -1.29245240179828 -1 3.79068992982377 3437 1234 911 1048 2036 4080 2813 2525 1508 598 4282 1874 M14517 GO_CELLULAR_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 39/108 Gene Ontology BP GO:0071277 0.0132758070451608 0.0499510308838586 1365 1934.27272727273 2041 0.00121423661391461 598 2.11507868358064 2.11507868358064 1 10.4487201440267 1361 2060 598 2337 3961 2093 1176 1982 891 2041 2777 1875 M16658 GO_LOCOMOTORY_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_EXPLORATION_BEHAVIOR.html The specific movement from place to place of an organism in response to a novel environment. 8/24 Gene Ontology BP GO:0035641 0.0765897756730953 0.158445571591463 2695 2277.81818181818 2042 0.00793650793650794 417 1.72130338621463 1.72130338621463 1 5.22780913330892 2693 2757 4597 1823 3342 1862 2042 2391 417 1536 1596 1876 M15509 GO_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. 145/300 Gene Ontology BP GO:0030099 0.0427756768662463 0.109788539353224 2790 2433.72727272727 2044 0.00396643216861028 895 1.13998933792367 1.19599878898741 1 4.15171177637959 2788 2282 1815 1510 895 3796 3868 1836 1907 2044 4030 1877 M16375 GO_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_MATURATION.html Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 12/23 Gene Ontology BP GO:0090128 0.298735036746822 0.413174493778819 3250 2276.81818181818 2044 0.0317460317460317 1314 1.51935086267539 -1.51935086267539 -1 2.21383636297702 3246 2078 1554 1743 2941 1979 3672 2583 2044 1891 1314 1878 M15679 GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 96/308 Gene Ontology BP GO:0006140 0.00520703818686889 0.0257194450017365 3580 2243.90909090909 2046 0.000474491216571934 505 1.25066635347379 1.28476664463951 1 7.54700024325255 3579 2046 505 2319 1035 1867 3798 2330 1912 1050 4242 1879 M10567 GO_RESPONSE_TO_AMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. 30/77 Gene Ontology BP GO:0014075 0.00713675869530331 0.0319229004068336 2050 1988.81818181818 2047 0.000650910536328611 315 1.9083122944764 1.9083122944764 1 10.8357396400736 2047 1641 1814 1909 315 3006 2512 2256 1481 2541 2355 1880 M10671 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. 32/82 Gene Ontology BP GO:0051148 0.232850105696956 0.342669743502683 3435 2416.72727272727 2047 0.0238095238095238 392 1.3904639784506 -1.07272638267715 -1 2.45491210500994 3435 392 1180 1012 2047 3573 3779 3031 1783 1742 4610 1881 M14101 GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 9/18 Gene Ontology BP GO:0046475 0.0450031974975505 0.114117884205968 1325 2083.09090909091 2047 0.00459414315818112 464 1.82051220676583 1.82051220676583 1 6.51402751176623 1323 3154 4187 2898 966 2623 2535 1106 464 1611 2047 1882 M14363 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 8/12 Gene Ontology BP GO:1900102 0.123782582446381 0.217204282047826 1765 2434.54545454545 2048 0.013127179566691 564 0.323743513779024 0.390725539465836 1 0.814906987984296 1765 1869 4229 2524 2857 1918 564 1660 3359 3987 2048 1883 M12656 GO_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 375/1075 Gene Ontology BP GO:0051046 6.42974619909303e-05 0.00100024485067937 920 1727.72727272727 2051 5.84539465755491e-06 240 1.19060378807335 1.34532856191571 1 13.557523112729 918 2086 240 2051 2060 2621 2114 1099 2433 1843 1540 1884 M10254 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 52/124 Gene Ontology BP GO:1903845 0.00344505492875407 0.019316501525172 2440 1911.90909090909 2053 0.000313678319474388 196 1.03442681662582 1.1083311866687 1 6.73032354799026 2437 1091 2053 891 196 3737 3137 1069 2371 655 3394 1885 M13168 GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 133/292 Gene Ontology BP GO:0009141 0.0895461108969356 0.16663831378536 1680 2123.36363636364 2053 0.0084921025215088 712 1.17190667769524 1.39060338940835 1 3.46182822865483 1133 1676 3389 2695 1260 712 2053 3396 2781 2584 1678 1886 M14575 GO_PEROXISOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOMAL_TRANSPORT.html Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 13/21 Gene Ontology BP GO:0043574 0.182581780659712 0.286007829825588 2055 2648.45454545455 2054 0.0181607439753504 792 0.163608270887855 -0.179478842147104 -1 0.33760554527066 2054 4563 3406 4353 1666 792 872 1772 4335 4047 1273 1887 M15113 GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. 52/124 Gene Ontology BP GO:0030512 0.00344505492875407 0.019316501525172 2440 1917.54545454545 2054 0.000313678319474388 197 1.03442681662582 1.1083311866687 1 6.73032354799026 2438 1092 2054 892 197 3738 3138 1121 2372 656 3395 1888 M11452 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. 12/24 Gene Ontology BP GO:2000725 0.0855903275783608 0.160522821720471 4140 2539.81818181818 2055 0.00810124196050115 654 1.0923235667937 1.0923235667937 1 3.29406623887946 4140 654 2038 1652 1240 2055 3096 3610 3154 1859 4440 1889 M14185 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 60/165 Gene Ontology BP GO:0002065 0.00238871083077618 0.0147877125163918 2335 1796.36363636364 2055 0.000217391671726076 321 1.54462531375416 1.61159018109526 1 10.7301294877813 2333 2409 438 795 3368 3364 1474 2055 690 321 2513 1890 M16126 GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. 33/105 Gene Ontology BP GO:2000177 0.298735036746822 0.413174493778819 4525 2298.36363636364 2055 0.0317460317460317 524 1.31716564311295 1.31716564311295 1 1.91923358085768 4521 524 1378 1061 2587 2035 3573 2143 2055 1762 3643 1891 M10188 GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 15/42 Gene Ontology BP GO:0052646 0.001685925742301 0.0113775482870691 3065 1906 2056 0.000153383555035489 125 1.01240235044132 -1.01240235044132 -1 7.4704327309637 3062 730 1402 393 125 2886 3173 4501 142 2056 2496 1892 M10537 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 15/23 Gene Ontology BP GO:1902254 0.0130046783696071 0.0492903850368046 2180 1494.72727272727 2057 0.00118929037383823 215 2.31622896548935 2.31622896548935 1 11.4932621666509 2179 2502 2309 747 460 2982 2256 411 215 2057 324 1893 M13169 GO_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium. 26/89 Gene Ontology BP GO:0003341 0.153358643659311 0.256500065745743 1430 2126.90909090909 2058 0.0150204238760605 503 1.09835599373909 -0.900270877697453 -1 2.46361900972771 1427 3777 2573 3057 1884 503 1637 2058 3028 2468 984 1894 M13483 GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. 204/405 Gene Ontology BP GO:0007264 0.161385165508919 0.258740097879113 2060 2309 2060 0.0158730158730159 784 1.21128139400842 1.29255743970284 1 2.69954878846367 2060 2194 1590 1773 3412 4064 1879 2456 1557 784 3630 1895 M11436 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 9/31 Gene Ontology BP GO:0010804 0.0173444190163526 0.0600971175320337 2630 2122.81818181818 2061 0.00174812980091386 573 1.45023161899474 1.45023161899474 1 6.72221377115612 2629 1402 3746 1629 573 2699 2061 2450 1744 1591 2827 1896 M16560 GO_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_AGGREGATION.html The adhesion of one platelet to one or more other platelets via adhesion molecules. 30/83 Gene Ontology BP GO:0070527 0.00560635830856133 0.0270867030454217 2435 2145.18181818182 2061 0.000510972401995371 512 1.83050239792877 1.83050239792877 1 10.8896546883558 2431 2061 512 1929 1901 4197 2787 2295 1455 932 3097 1897 M10929 GO_ACTIVATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_GTPASE_ACTIVITY.html Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. 52/108 Gene Ontology BP GO:0090630 0.019966908611591 0.0658893793060532 3075 2422.81818181818 2063 0.0018318601981081 584 1.25385362125731 -1.16316054128375 -1 5.62175402762843 3074 2379 1513 2063 584 3944 2022 4185 1742 1020 4125 1898 M12059 GO_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 43/132 Gene Ontology BP GO:0043542 0.0187790306204833 0.0633720848195633 645 2460.54545454545 2063 0.00172193355641756 644 1.32950558757906 1.32950558757906 1 6.04632089946345 3159 1837 645 840 644 4109 4470 4607 2063 813 3879 1899 M12075 GO_COFACTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. 15/37 Gene Ontology BP GO:0051187 0.0839184282471183 0.158445571591463 3300 2335.63636363636 2067 0.00793650793650794 749 0.964916235402726 -0.810865129405406 -1 2.93056874725372 3298 1236 2458 902 1972 1787 3215 4386 749 2067 3622 1900 M15272 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. 15/52 Gene Ontology BP GO:0001937 0.186873874848622 0.291452939510296 1185 2288.09090909091 2067 0.0186305422441838 1181 0.441259496323929 0.453721992506155 1 0.896819953351624 1181 2074 1611 3228 1680 2641 1558 1327 3576 4226 2067 1901 M15885 GO_NAD_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. 8/16 Gene Ontology BP GO:0009435 0.209953447027022 0.318983591147402 2455 2266.36363636364 2067 0.023290823094293 947 1.08991325512181 1.08991325512181 1 2.05297486325641 2452 977 4473 2067 1805 1073 947 3468 3522 1526 2620 1902 M13823 GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. 99/225 Gene Ontology BP GO:0006352 0.0142976721132034 0.0526380793457477 1835 2079.72727272727 2068 0.00130831328869227 112 1.19851050335346 1.19851050335346 1 5.81725000913223 1831 3340 3201 3724 1384 112 2068 1638 2428 2781 370 1903 M14047 GO_ACTIVATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_IMMUNE_RESPONSE.html Any process that initiates an immune response. 213/757 Gene Ontology BP GO:0002253 0.161385165508919 0.258740097879113 2075 2232.27272727273 2068 0.0158730158730159 1341 1.33618918328782 1.43465051807659 1 2.9779272667503 2071 2611 1341 1936 2068 4348 2183 1928 1619 1369 3081 1904 M12209 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 14/30 Gene Ontology BP GO:0010523 0.00388309076682465 0.0210621383532323 2550 1888.27272727273 2071 0.000353632869671235 218 1.77226300180235 1.77226300180235 1 11.2781618408398 2546 2820 845 1615 218 4131 2071 2962 315 913 2335 1905 M13000 GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. 104/204 Gene Ontology BP GO:0007265 0.162958275384097 0.260452761655203 1825 2252.72727272727 2071 0.0160409834897046 1040 1.18122525156887 1.29503233590532 1 2.61971658238335 1825 2242 1040 1672 3083 4249 2376 1966 2071 1165 3091 1906 M10377 GO_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. 27/78 Gene Ontology BP GO:0031060 0.00176804324646614 0.0117945758525033 1305 1856.27272727273 2072 0.000160860522345861 130 1.13115893914357 -1.13115893914357 -1 8.27960168790863 1301 3144 2808 3224 130 181 1896 2072 3034 2487 142 1907 M11375 GO_CARDIAC_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MYOFIBRIL_ASSEMBLY.html The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. 15/41 Gene Ontology BP GO:0055003 0.000312514221293684 0.00339019516230508 3370 2534.45454545455 2073 2.84144203062793e-05 310 2.2702248085889 -2.07333958077616 -1 21.2830340247196 3370 2073 310 1490 866 4121 3825 4598 1955 959 4312 1908 M13403 GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 15/38 Gene Ontology BP GO:0045662 0.0325740606739458 0.0915464107095893 3900 2148.54545454545 2073 0.00300605506036264 111 1.07272638267715 -1.07272638267715 -1 4.22808383469374 3899 111 1485 369 772 2821 4181 3026 468 2073 4429 1909 M15684 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. 8/30 Gene Ontology BP GO:0060850 0.288472608756631 0.40698217029992 670 2347.45454545455 2074 0.0334614901008804 667 1.31505585488108 1.31505585488108 1 1.94889581358586 667 2543 4440 2336 3905 1143 1611 2074 3558 1524 2021 1910 M12078 GO_VENTRAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. 16/71 Gene Ontology BP GO:0021517 0.286268552968098 0.404856805187596 2765 2460.18181818182 2075 0.0301937363572509 1001 1.69770075511385 -1.48620652365728 -1 2.53062432078853 2761 2500 1190 2009 2075 4550 4627 1645 1993 1001 2711 1911 M14222 GO_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 161/453 Gene Ontology BP GO:0006066 0.121111914939798 0.213429513266965 2580 2460 2075 0.0116675554251004 1061 1.17383572798054 -1.04172901199495 -1 2.98863129359403 2576 1720 1061 2032 1415 4288 1990 3297 2075 2266 4340 1912 M15213 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that activates or increases the rate or extent of osteoblast proliferation. 12/22 Gene Ontology BP GO:0033690 0.0416741492030049 0.108036334310191 510 1726.54545454545 2075 0.00386228777070261 332 0.40855090741961 0.423063091808077 1 1.49873167222304 506 2075 2314 2194 2870 447 332 906 2568 4213 567 1913 M10076 GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that activates or increases the frequency, rate or extent of protein maturation. 10/42 Gene Ontology BP GO:1903319 0.205042000772808 0.313367350094847 4330 2515.90909090909 2076 0.0206444690953702 1028 1.11882204112119 1.11882204112119 1 2.14019067074287 4327 1740 1274 1028 1735 2630 4021 2076 2824 1672 4348 1914 M10980 GO_CELLULAR_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 8/24 Gene Ontology BP GO:0071276 0.00618601491146404 0.0290999668023582 1675 2179.45454545455 2076 0.000620330273159945 309 0.428653389914915 0.457875960964826 1 2.49939619923492 1675 2231 3665 1648 309 1580 694 4346 2622 3128 2076 1915 M16140 GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 48/144 Gene Ontology BP GO:0002285 0.0369746970590631 0.0989472728790952 1610 2284.90909090909 2076 0.00341919504920747 599 0.96884206496509 0.953379308165877 1 3.69446652841183 1607 3709 2076 3253 3828 1998 1370 599 2561 2274 1859 1916 M10847 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. 8/15 Gene Ontology BP GO:0043923 0.0348986070800974 0.0955442502601261 835 2135.90909090909 2077 0.00354590963924455 832 0.396495360152917 -0.410776816209208 -1 1.53482338485669 2603 832 3647 1926 835 1592 2425 2478 2077 3102 1978 1917 M10689 GO_PHOTOPERIODISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOPERIODISM.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. 15/67 Gene Ontology BP GO:0009648 0.0413607403693172 0.107463859840369 2415 2087 2078 0.00383267628648794 883 0.849254971022537 0.849254971022537 1 3.12285248171677 2411 1491 1363 2078 883 1594 1625 2775 3536 3074 2127 1918 M11017 GO_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 19/43 Gene Ontology BP GO:0060996 0.0839184282471183 0.158445571591463 2655 1845.54545454545 2079 0.00793650793650794 544 0.997294518871526 -0.680644994905029 -1 3.02890555841693 2651 544 2079 1144 1631 1450 2539 2754 947 2236 2326 1919 M11419 GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. 15/39 Gene Ontology BP GO:0043508 0.0839184282471183 0.158445571591463 3020 2144.72727272727 2079 0.00793650793650794 685 2.35459573801311 2.35459573801311 1 7.1511955435219 3019 2890 1660 2079 2891 937 1053 4084 685 2065 2229 1920 M12302 GO_LIPOPROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_TRANSPORT.html The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/19 Gene Ontology BP GO:0042953 0.0153315396572146 0.0548838385724345 1755 2207 2080 0.0015438353535535 288 0.410837507342742 0.516804584706065 1 1.96579984160016 1753 2080 3887 2572 3742 1720 288 410 3691 3460 674 1921 M13338 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleotide across a membrane. 7/13 Gene Ontology BP GO:1901679 0.0010797028477115 0.00830040181453953 2080 2257.63636363636 2080 0.000108022779792191 99 0.373066405087709 -0.406600086529462 -1 2.94676001257815 2080 1914 4054 2338 4253 1006 1981 99 3015 3711 383 1922 M14795 GO_PHOSPHOLIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORT.html The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. 26/68 Gene Ontology BP GO:0015914 0.0338090319994326 0.0934933505499497 1600 2201.09090909091 2080 0.00312182374889827 568 1.60847139939289 1.60847139939289 1 6.28388871823814 1597 3176 1940 2080 3059 3353 2816 568 1944 1453 2226 1923 M14060 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. 2/15 Gene Ontology BP GO:0044794 0.000377450567232182 0.00392634179109736 905 2202.8 2080.5 4.19459890899094e-05 25 0.604660531680317 0.604660531680317 1 5.52225711222779 904 2726 4178 NA 4274 1435 25 638 3625 3910 313 1924 M14212 GO_LIPOPROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_LOCALIZATION.html Any process in which a lipoprotein is transported to, or maintained in, a specific location. 9/19 Gene Ontology BP GO:0044872 0.0148709581525747 0.0538579241048395 1755 2280.27272727273 2081 0.00149714210681736 289 0.410837507342742 0.516804584706065 1 1.97857950146791 1754 2081 4206 2573 3743 1721 289 402 3692 3947 675 1925 M15965 GO_RESPONSE_TO_GONADOTROPIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GONADOTROPIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 17/37 Gene Ontology BP GO:0034698 0.0326772628023048 0.0917043506015362 1440 2013.27272727273 2082 0.00301572428881514 725 1.08918898596586 1.08918898596586 1 4.28987508095599 1440 2114 725 2082 4629 1591 839 2551 3021 2161 993 1926 M10124 GO_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ACTIVATION.html A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. 245/670 Gene Ontology BP GO:0045321 0.298735036746822 0.413174493778819 1965 2336.81818181818 2083 0.0317460317460317 1248 1.31207837057258 1.35596406554877 1 1.91182094878182 1961 2550 1248 1997 2086 4119 2481 1885 2083 1906 3389 1927 M10111 GO_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSPORT.html The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 480/1474 Gene Ontology BP GO:0006811 0.000132572197277257 0.00180508126673989 2085 1878.09090909091 2084 1.20527442512533e-05 175 1.27605127675673 1.43533706786463 1 13.2886491439304 2084 175 267 760 2105 3727 2748 3136 1086 896 3675 1928 M12740 GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 16/55 Gene Ontology BP GO:0032689 0.0221340156546006 0.070485757670995 3060 2340.27272727273 2084 0.00203271746756695 511 1.46011056855438 1.46011056855438 1 6.38421106226103 3058 3010 671 1966 2084 3621 4626 1417 1844 511 2935 1929 M13625 GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. 61/159 Gene Ontology BP GO:0046887 0.0307847244950753 0.0881214113235105 1020 2102.27272727273 2084 0.00283855722201687 551 1.50707418051067 -0.816391131298516 -1 6.03477096494916 1017 3341 1413 2753 3623 2084 1742 551 2767 2799 1035 1930 M15119 GO_OSTEOBLAST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DEVELOPMENT.html The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. 15/31 Gene Ontology BP GO:0002076 0.0839184282471183 0.158445571591463 1810 1944.45454545455 2084 0.00793650793650794 132 2.51960658933014 2.51960658933014 1 7.65235370224517 1810 1287 2242 794 3442 2738 2540 1954 132 2084 2366 1931 M10383 GO_EPIDERMIS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_MORPHOGENESIS.html The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 27/52 Gene Ontology BP GO:0048730 0.0133438001122064 0.0500924017811142 1975 2310.54545454545 2085 0.00122049355573455 600 1.26806994331976 1.34719556037237 1 6.25849633597407 1972 1848 600 2085 3741 3330 3333 2977 2121 1469 1940 1932 M13374 GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. 15/57 Gene Ontology BP GO:2000179 0.161385165508919 0.258740097879113 3510 2130.54545454545 2085 0.0158730158730159 872 1.63639951871907 1.63639951871907 1 3.64699760115783 3507 966 2278 893 2773 872 2472 4198 1320 2072 2085 1933 M14845 GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 37/107 Gene Ontology BP GO:0042108 0.161385165508919 0.258740097879113 2085 2158.63636363636 2085 0.0158730158730159 519 1.13871921590628 1.13871921590628 1 2.53783150215373 2085 519 2327 1415 4214 2931 2567 1533 1430 1973 2751 1934 M13063 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. 7/30 Gene Ontology BP GO:0002532 0.212766966281449 0.322414172468919 1875 2667.81818181818 2086 0.023639208109776 1389 0.438412091456772 -0.584171992506922 -1 0.818067521743609 1872 3925 4003 3428 1811 1389 1730 2086 3729 3641 1732 1935 M12325 GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. 4/31 Gene Ontology BP GO:0021895 0.0611857858239629 0.141406472663345 2780 2332.18181818182 2087 0.00629387748532028 772 1.14672566625037 1.14672566625037 1 3.69782068569739 2776 1558 3891 1654 2062 3365 4249 772 2146 1094 2087 1936 M13395 GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 6/24 Gene Ontology BP GO:0071872 0.236014009369357 0.346776280222128 1515 2538.63636363636 2087 0.0265614536701571 1249 0.307035177712674 0.413280862120569 1 0.536051570160728 1511 3120 4068 3193 1877 1249 2087 1904 3796 3729 1391 1937 M15212 GO_MEMBRANE_PROTEIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. 24/63 Gene Ontology BP GO:0033619 0.119159433454167 0.210604206139208 4515 2537.45454545455 2089 0.0114681552354582 1358 1.21102698442334 1.19936205718047 1 3.10992568228201 4511 2019 1802 1807 1402 2724 3133 4287 2089 1358 2780 1938 M13818 GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. 12/21 Gene Ontology BP GO:0031293 0.171109407114615 0.272029640537428 2120 2117.27272727273 2090 0.0169159374108514 968 0.653874098340854 0.653874098340854 1 1.40328119183857 2120 968 3031 2292 1607 990 2622 1823 2090 3840 1907 1939 M15834 GO_CYTOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOLYSIS.html The rupture of cell membranes and the loss of cytoplasm. 18/49 Gene Ontology BP GO:0019835 0.278540027877477 0.395855937996671 1400 2229.09090909091 2091 0.0292437313110595 1183 1.68373715897236 1.68373715897236 1 2.57221526295943 1396 1787 1183 1894 2419 2479 1526 4245 3289 2211 2091 1940 M10058 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 24/48 Gene Ontology BP GO:0042992 0.112942808684734 0.201612249413003 3100 2191.81818181818 2092 0.0108359383162048 941 1.10024927344512 1.32793768360073 1 2.90459037101076 3100 1227 2591 965 2092 4117 2802 941 1757 1349 3169 1941 M12038 GO_SPECIFICATION_OF_SYMMETRY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_SYMMETRY.html The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. 76/206 Gene Ontology BP GO:0009799 0.161385165508919 0.258740097879113 3275 2126.81818181818 2092 0.0158730158730159 828 1.19950212938765 1.35407478943366 1 2.67329667256777 3274 1885 1458 2092 2724 828 2469 3241 1491 1638 2295 1942 M10790 GO_INDOLALKYLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLALKYLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. 6/18 Gene Ontology BP GO:0006586 0.0143129661642174 0.0526380793457477 1140 2173.36363636364 2093 0.00144059980520479 199 1.03069309216194 -1.03069309216194 -1 5.00270909848976 1137 3448 3636 3373 2889 789 199 2093 4046 1307 990 1943 M15858 GO_TRYPTOPHAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRYPTOPHAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. 6/13 Gene Ontology BP GO:0006568 0.0143129661642174 0.0526380793457477 1140 2252.72727272727 2094 0.00144059980520479 200 1.03069309216194 -1.03069309216194 -1 5.00270909848976 1138 3449 4467 3374 2890 790 200 2094 4047 1340 991 1944 M14412 GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). 38/201 Gene Ontology BP GO:0007188 0.130390791248415 0.226404055260431 1420 2088 2095 0.0126207144346901 1153 1.1866416600189 1.1866416600189 1 2.90579184065055 1420 2203 1153 2584 1458 2731 1322 3499 2095 2652 1851 1945 M11947 GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT.html The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. 66/243 Gene Ontology BP GO:0015850 0.000731786964820552 0.00661028575420588 1255 1924.18181818182 2097 6.65482266230825e-05 351 1.58080012475223 1.58080012475223 1 13.0796706812312 1253 703 351 1424 2097 3250 1442 2989 2586 2572 2499 1946 M13459 GO_ERYTHROCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. 5/16 Gene Ontology BP GO:0043249 0.104637125184163 0.18900991267086 2215 2232.27272727273 2097 0.0109917638271605 950 0.483765437564215 -0.678943812330734 -1 1.32858657218589 2215 1459 4078 1875 2633 1166 2097 950 2912 3745 1425 1947 M15070 GO_MOTILE_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM_ASSEMBLY.html The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function. 21/57 Gene Ontology BP GO:0044458 0.090139395674551 0.167473875196855 2100 1929.18181818182 2097 0.00855085651817091 378 1.09835599373909 -0.900270877697453 -1 3.23550219300859 2097 2422 2735 2531 1266 378 1460 3236 2066 2333 697 1948 M16703 GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 9/13 Gene Ontology BP GO:0007260 0.0151703633273416 0.0545838317673368 1785 2589.54545454545 2097 0.00152749323900793 406 0.506082111889238 0.596200368118451 1 2.42610478364027 1781 1866 4607 2097 3516 3060 1571 406 3011 4571 1999 1949 M15621 GO_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_P38MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of p38MAPK cascade. 19/45 Gene Ontology BP GO:1900744 0.251884869941927 0.36569776458423 1600 2205.27272727273 2098 0.0260367161794106 975 1.35593454827845 1.35593454827845 1 2.24856698099184 1599 3718 1745 2928 1866 2098 1128 2668 3283 2250 975 1950 M16030 GO_MATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING_BEHAVIOR.html The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. 9/27 Gene Ontology BP GO:0007617 0.0337244293394241 0.0933706174257282 3030 2206.81818181818 2099 0.00342474370297684 387 2.06322935667965 2.06322935667965 1 8.0649803304895 3029 2539 4496 602 820 2684 4266 2099 387 1629 1724 1951 M10854 GO_LUNG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_CELL_DIFFERENTIATION.html The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. 16/33 Gene Ontology BP GO:0060479 0.00257297768712635 0.0157188623701679 3015 2293.45454545455 2101 0.000234181073792766 159 1.29829314601985 -1.29829314601985 -1 8.8882270175775 3012 1655 2271 2037 159 3077 1382 4572 745 2101 4217 1952 M11083 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. 14/46 Gene Ontology BP GO:0002719 0.175335508966791 0.276241183621585 1730 2113.81818181818 2101 0.0173726566463547 1190 1.00744291305309 1.00744291305309 1 2.13656123829855 1728 2217 1896 2101 1636 2596 2518 1190 2932 2009 2429 1953 M14425 GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. 33/76 Gene Ontology BP GO:0009168 0.0175920939472158 0.0607286930832141 1370 2196.90909090909 2102 0.0016122147949642 548 0.648828184364399 0.648828184364399 1 2.99631118251031 1370 2102 3363 2455 548 798 1932 2597 3221 4012 1768 1954 M11354 GO_HYPEROSMOTIC_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPEROSMOTIC_RESPONSE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. 16/43 Gene Ontology BP GO:0006972 0.161923131186661 0.259244516586092 1320 2054.63636363636 2103 0.0159304244988059 778 1.0182775376699 -0.889829409089437 -1 2.26613716436487 1320 3057 2217 2109 4035 1241 778 1107 3629 2103 1005 1955 M15156 GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 33/76 Gene Ontology BP GO:0009127 0.0175920939472158 0.0607286930832141 1375 2215.45454545455 2103 0.0016122147949642 549 0.648828184364399 0.648828184364399 1 2.99631118251031 1371 2103 3364 2456 549 799 1933 2609 3222 4195 1769 1956 M16049 GO_STRIATED_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_ADAPTATION.html Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 19/42 Gene Ontology BP GO:0014888 0.0189662680198354 0.0638118713160114 2095 2322.81818181818 2103 0.00173925253582184 647 1.70820157422404 1.70820157422404 1 7.74907844146672 2093 1385 647 1295 3284 2826 2103 4473 1973 2252 3220 1957 M11530 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 16/35 Gene Ontology BP GO:0043243 0.0839184282471183 0.158445571591463 3140 2432.63636363636 2104 0.00793650793650794 735 1.63639951871907 1.63639951871907 1 4.96994569243248 3139 1903 1506 2081 3543 4284 2416 1423 735 2104 3625 1958 M15745 GO_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON_REORGANIZATION.html A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. 30/107 Gene Ontology BP GO:0031532 0.21079256507004 0.319896671324082 1205 2422.45454545455 2104 0.0212906382431013 1205 0.790568008275565 0.790568008275565 1 1.48539903297909 1205 2104 1680 2378 4036 2503 1760 1221 3880 4342 1538 1959 M10232 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. 16/23 Gene Ontology BP GO:0070230 0.0737020123142466 0.158445571591463 1815 2041 2105 0.00693577166143288 848 1.66432443968961 1.66432443968961 1 5.05475709643647 1815 2353 848 2105 2845 3123 2403 1686 2398 994 1881 1960 M12951 GO_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. 25/52 Gene Ontology BP GO:0045445 0.466738071388703 0.580826820010117 1850 2266.18181818182 2105 0.0555555555555556 918 1.40157285696625 -1.07272638267715 -1 1.25530435362223 1849 2105 1411 918 3963 3709 1804 2750 2483 1382 2554 1961 M12183 GO_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIVISION.html The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. 16/47 Gene Ontology BP GO:0017145 0.225492939633975 0.337730231845338 2110 2129 2106 0.0229621277974736 861 1.65735694990685 1.65735694990685 1 2.96579110101755 2106 3389 1883 3039 2195 2238 2109 1505 1988 2106 861 1962 M12779 GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the cytosol. 34/99 Gene Ontology BP GO:0060401 0.0618061697267945 0.142107321583235 2055 2491.72727272727 2106 0.00578309580845974 821 1.19095298537442 1.19095298537442 1 3.83073293277258 2051 3713 821 3519 1583 4069 3762 2106 1101 1837 2847 1963 M13288 GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. 8/17 Gene Ontology BP GO:0030007 0.0956179249911956 0.176032524081729 2320 2087.36363636364 2106 0.01 153 1.38933387508025 1.38933387508025 1 3.97850230190943 2319 153 4044 1337 2283 2780 1140 3609 1674 1516 2106 1964 M12261 GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. 16/46 Gene Ontology BP GO:0030513 0.00365532545381251 0.0201211710357104 2375 1833.27272727273 2107 0.000332855725851258 206 1.44141515827619 1.44141515827619 1 9.28134564246701 2371 285 2252 1185 206 4383 2751 1517 342 2107 2767 1965 M15566 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 22/65 Gene Ontology BP GO:0010596 0.232850105696956 0.342669743502683 1420 2165.36363636364 2107 0.0238095238095238 1417 1.19045135446987 1.19045135446987 1 2.10178291978098 1417 2107 2345 1616 2690 3414 2349 1879 1814 2368 1820 1966 M15167 GO_EMBRYONIC_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_EYE_MORPHOGENESIS.html The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. 21/53 Gene Ontology BP GO:0048048 0.0839184282471183 0.158445571591463 2720 2028.54545454545 2108 0.00793650793650794 365 1.50626070609708 1.72302786780705 1 4.57469818482002 2717 2108 1284 2303 1870 2823 2048 2579 365 668 3549 1967 M10737 GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN.html Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. 2/16 Gene Ontology BP GO:2000047 0.00407151183911629 0.0217154624001856 3195 1894.1 2109 0.000453210936713034 258 1.46584243959724 1.46584243959724 1 9.2543745400065 3194 456 3627 NA 258 2584 1052 2304 1914 846 2706 1968 M13261 GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of B cell mediated immunity. 19/54 Gene Ontology BP GO:0002712 0.161385165508919 0.258740097879113 2470 2116.27272727273 2109 0.0158730158730159 1472 1.11882204112119 1.11882204112119 1 2.49348722810301 2469 1597 2155 1867 1674 3430 1472 2109 1578 2241 2687 1969 M11468 GO_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORELIMB_MORPHOGENESIS.html The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 19/58 Gene Ontology BP GO:0035136 0.0809296272819048 0.158445571591463 4000 2239.09090909091 2110 0.00764269803239471 777 1.13864685107115 -0.932815312911666 -1 3.45820989792549 3999 2110 1125 1489 1205 2907 3298 3108 777 1119 3493 1970 M16306 GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of a defense response. 213/564 Gene Ontology BP GO:0031349 0.15117832689121 0.253309625317896 2155 2320.54545454545 2110 0.0147900958324435 1269 1.41102755429307 1.41102755429307 1 3.19405740139613 2151 1823 1269 2377 1544 4423 1942 2110 1630 2507 3750 1971 M12061 GO_GLYCEROLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. 167/425 Gene Ontology BP GO:0046486 0.026820781738332 0.0801344205991476 2115 2211.27272727273 2112 0.00246849572549633 693 1.27756370969814 -0.996017559443501 -1 5.31584155738066 2112 1466 1195 1425 693 4007 2674 2152 2013 2757 3830 1972 M12218 GO_ANATOMICAL_STRUCTURE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. 20/76 Gene Ontology BP GO:0071695 0.0805735631066401 0.158445571591463 1110 2135.45454545455 2113 0.00760775356451464 827 0.883553879206052 0.883553879206052 1 2.68346130980058 1107 2814 1066 2564 2393 1788 2113 827 3777 3437 1604 1973 M10772 GO_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ASSEMBLY.html Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. 145/403 Gene Ontology BP GO:0030031 0.00271647359788905 0.0162743056967727 1525 1849.09090909091 2114 0.000247257600232796 41 1.14692861603597 1.47289696559612 1 7.78631491199419 1522 2195 2450 2114 2722 41 1735 3590 1192 2426 353 1974 M12930 GO_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 16/81 Gene Ontology BP GO:0002377 0.00220446277656228 0.0139826785130856 2115 1951.63636363636 2115 0.000200606801356972 148 1.11483649486921 1.11483649486921 1 7.84736912706058 3121 2115 2446 1126 148 4132 2173 276 590 2111 3230 1975 M13092 GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION.html Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. 21/62 Gene Ontology BP GO:0002026 0.00624948372934274 0.0292503558017523 2190 2183.81818181818 2115 0.000569755218371146 525 1.24294205343768 -1.36172616824467 -1 7.23679616206088 2189 1693 525 1610 2115 3182 1491 4051 2642 1227 3297 1976 M13797 GO_RESPONSE_TO_AUDITORY_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AUDITORY_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. 16/48 Gene Ontology BP GO:0010996 0.0492629525834098 0.121084112675898 4090 2199.45454545455 2115 0.00458199374565351 554 1.51935086267539 -1.51935086267539 -1 5.28802330634288 4087 554 1631 836 964 2158 3237 4316 1472 2115 2824 1977 M14354 GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed. 55/137 Gene Ontology BP GO:0006733 0.0863243006845962 0.161419141392904 3540 2183.72727272727 2115 0.00817364761812191 341 1.29641899176713 1.36363565731954 1 3.89764655727527 3539 867 2062 2033 2874 341 2929 3769 2435 1057 2115 1978 M13048 GO_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEARNING.html Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. 65/227 Gene Ontology BP GO:0007612 0.0839184282471183 0.158445571591463 3430 1815 2117 0.00793650793650794 373 1.26581737349215 1.33363714401395 1 3.84444234477188 3430 373 2636 1142 2471 1271 2690 2117 579 895 2361 1979 M15731 GO_PHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 13/34 Gene Ontology BP GO:0009395 0.0839184282471183 0.158445571591463 1760 2578.45454545455 2119 0.00793650793650794 823 1.82051220676583 1.82051220676583 1 5.52911846805698 1758 4340 1973 4424 1447 3560 3015 2119 823 1962 2942 1980 M12274 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that stops, prevents or reduces the rate of gene expression. 63/125 Gene Ontology BP GO:0045814 0.2073110367773 0.31569207732273 525 2125.18181818182 2120 0.0208989229370616 522 1.03463152579236 -1.03463152579236 -1 1.9665365803524 522 3136 1960 3157 2778 1018 2120 1671 2884 2804 1327 1981 M15263 GO_OLIGODENDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DEVELOPMENT.html The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. 16/53 Gene Ontology BP GO:0014003 0.0839184282471183 0.158445571591463 2515 2187 2120 0.00793650793650794 686 1.1817781444396 1.1817781444396 1 3.58920491670979 2514 1654 2485 1097 1341 3966 2915 3397 686 2120 1882 1982 M11102 GO_PENTOSE_PHOSPHATE_SHUNT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_PHOSPHATE_SHUNT.html The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. 5/16 Gene Ontology BP GO:0006098 0.0765897756730953 0.158445571591463 2290 2073.09090909091 2121 0.00793650793650794 278 1.09476899510989 -1.09476899510989 -1 3.32494747714069 2287 2833 3691 1495 3280 2121 1972 1280 278 1186 2381 1983 M14888 GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. 20/59 Gene Ontology BP GO:0032881 0.0175864400223175 0.0607286930832141 2305 2253 2122 0.00161169244252832 547 1.82051220676583 1.82051220676583 1 8.40718885937408 2302 1486 1553 1504 547 4607 3242 2122 1963 2299 3158 1984 M11614 GO_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_KETONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 39/102 Gene Ontology BP GO:0042180 0.0141575595963052 0.0524609331250162 1735 2309.90909090909 2123 0.00129540876904333 473 0.30551620983607 -0.303150122625924 -1 1.48459192823183 1732 3495 2945 3772 473 1009 2123 1415 3737 3300 1408 1985 M12976 GO_REGULATION_OF_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METAL_ION_TRANSPORT.html Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 174/505 Gene Ontology BP GO:0010959 0.0609320729914669 0.140890246463835 1840 2296.18181818182 2123 0.0056989230550871 815 1.41339886772373 1.54690218938607 1 4.56627740873792 1836 2657 815 2418 1818 4215 2829 2123 1171 2049 3327 1986 M12277 GO_ALDITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 10/26 Gene Ontology BP GO:0019400 0.145239693721778 0.247104396463986 2610 2139.54545454545 2124 0.014165457058145 694 1.23889395501682 -1.23889395501682 -1 2.8550621517022 2607 2031 2303 2146 4123 2124 3046 1197 1576 1688 694 1987 M12205 GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE.html Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. 12/38 Gene Ontology BP GO:1902668 0.0655665256999007 0.14799575097335 1475 2368.63636363636 2125 0.00614602121020317 819 1.31853882585007 1.31853882585007 1 4.15286495743892 1475 2076 837 2125 4198 3018 1726 3520 3490 819 2771 1988 M13181 GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 11/22 Gene Ontology BP GO:0071243 0.15790260720223 0.258740097879113 1970 2403.81818181818 2125 0.0155021849691713 1096 1.35593454827845 1.35593454827845 1 3.02193320658013 1970 3759 2643 4125 2977 2125 1124 1096 3282 1795 1546 1989 M14739 GO_HINDBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_MORPHOGENESIS.html The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. 33/80 Gene Ontology BP GO:0021575 0.0496306544168316 0.12185887279606 4185 2266.63636363636 2125 0.00461699829938224 594 1.26388779104707 -1.27502197741866 -1 4.38560802976578 4181 2015 1387 1104 970 2265 4449 2125 2423 594 3420 1990 M13777 GO_LONG_TERM_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_MEMORY.html The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. 14/45 Gene Ontology BP GO:0007616 0.161385165508919 0.258740097879113 2130 2054.18181818182 2127 0.0158730158730159 763 1.24287224182961 -1.24287224182961 -1 2.7699544228519 2127 2644 2946 2463 3214 1005 1515 2360 1534 2025 763 1991 M15314 GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. 5/16 Gene Ontology BP GO:0072505 8.16915227282775e-05 0.00123147318190712 4150 2145.90909090909 2127 8.16945259608585e-06 23 1.14211151586662 -0.802911170417016 -1 12.6137815151794 4150 579 4384 399 23 2560 3599 2127 39 1206 4539 1992 M13435 GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response. 10/29 Gene Ontology BP GO:0002739 0.0482947568621008 0.119526948886319 3970 2475.45454545455 2130 0.00448988208735055 301 1.46584243959724 1.46584243959724 1 5.13306757750844 3966 301 1738 2130 3674 4082 2957 681 1669 1697 4335 1993 M13757 GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR.html The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. 12/22 Gene Ontology BP GO:0042994 0.0393615424403449 0.10383843269916 2815 2315.90909090909 2130 0.0036439949874889 542 0.972406636028458 -0.644872453133905 -1 3.63071495635945 2815 2130 2800 1221 4130 4286 2117 620 542 1877 2937 1994 M16634 GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 152/389 Gene Ontology BP GO:0010976 0.35943518917414 0.479556776820555 1130 2186.72727272727 2132 0.0396825396825397 1127 1.57446996534926 1.57446996534926 1 1.90743621308718 1127 3036 1496 2361 2772 3309 1770 1996 2255 2132 1800 1995 M14154 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. 26/69 Gene Ontology BP GO:0060761 0.0246432269509547 0.0758240574773246 2135 2115.72727272727 2133 0.00226578865701587 661 1.59281764976282 1.59281764976282 1 6.77276702964746 2131 1529 1954 2264 661 3266 2673 2133 2358 1450 2854 1996 M16767 GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM.html A circulatory process that occurs at the level of the vasculature. 84/233 Gene Ontology BP GO:0003018 0.00134786408459518 0.00968751229841395 925 1942.63636363636 2133 0.000122608234855474 398 1.3855427239126 1.3855427239126 1 10.591094525632 923 1884 398 2161 2495 2133 1746 2904 1864 2709 2152 1997 M16433 GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION.html The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. 10/22 Gene Ontology BP GO:0060900 0.0839184282471183 0.158445571591463 2310 1998.36363636364 2134 0.00793650793650794 490 1.46584243959724 1.46584243959724 1 4.45194296080794 2310 2270 1773 2320 3545 2134 556 2005 490 1722 2857 1998 M16529 GO_POST_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. 47/154 Gene Ontology BP GO:0009791 0.0839184282471183 0.158445571591463 4320 2654 2134 0.00793650793650794 498 1.98887375284539 1.96071847686846 1 6.04045309701981 4561 2007 1899 2134 2013 2697 4319 4319 498 905 3842 1999 M10211 GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. 9/14 Gene Ontology BP GO:0008608 0.147859119791321 0.249186894080256 3560 2536.27272727273 2136 0.0158730158730159 1354 1.20238510924012 -0.674350887224881 -1 2.75429188057447 3558 2135 3554 1772 1644 2136 3135 3143 1354 1577 3891 2000 M15075 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 43/162 Gene Ontology BP GO:0050806 0.195069659287038 0.302003477182299 4465 2741.54545454545 2136 0.0195339221978043 1475 1.16267596550501 -1.16267596550501 -1 2.29487637292361 4462 3235 1475 2054 1702 2111 4345 3461 2040 2136 3136 2001 M10588 GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. 20/54 Gene Ontology BP GO:0030517 0.0972824939226479 0.178583014896726 1995 2351.36363636364 2137 0.00926099706766786 632 1.24477559610615 1.24477559610615 1 3.53502666567212 1995 1487 905 2008 3900 3689 2137 3285 2845 632 2982 2002 M16592 GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species. 9/27 Gene Ontology BP GO:0044705 0.0337244293394241 0.0933706174257282 3030 2219.90909090909 2138 0.00342474370297684 388 2.06322935667965 2.06322935667965 1 8.0649803304895 3030 2540 4588 603 821 2685 4267 2138 388 1634 1725 2003 M10793 GO_POSITIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BINDING.html Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 96/216 Gene Ontology BP GO:0051099 0.00617360727849994 0.0290830863501857 3725 2434 2139 0.000562818175609405 279 1.25956269341659 1.25956269341659 1 7.34547478462124 3721 1145 1695 2139 279 3199 3848 1773 1910 2545 4520 2004 M10713 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN.html The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. 17/37 Gene Ontology BP GO:0050965 0.161385165508919 0.258740097879113 3020 2269.27272727273 2140 0.0158730158730159 1126 1.31394404283802 1.31394404283802 1 2.92835014763378 3016 1900 1264 1944 2267 4151 1126 2747 1389 2140 3018 2005 M14854 GO_PHARYNGEAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHARYNGEAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. 8/36 Gene Ontology BP GO:0060037 0.0765897756730953 0.158445571591463 3435 2270.54545454545 2140 0.00793650793650794 149 0.732828919713025 0.753026183072446 1 2.22569115365469 3431 149 4305 1353 1232 2671 2140 1696 175 4115 3709 2006 M10602 GO_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_UPTAKE.html The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. 5/22 Gene Ontology BP GO:0001504 0.33296556889208 0.452829272514917 1610 2398 2141 0.0396825396825397 843 1.38933387508025 1.38933387508025 1 1.81449172368223 1610 843 3610 1607 3597 2676 3470 3818 2141 1181 1825 2007 M10630 GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. 10/23 Gene Ontology BP GO:0045618 0.000942086505993972 0.00779698332857399 4295 2445.36363636364 2141 8.56809244883175e-05 89 1.33403223803043 -1.33403223803043 -1 10.6747885964677 4292 1045 2141 1406 3105 3540 3813 89 1690 1674 4104 2008 M11130 GO_GLIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DEVELOPMENT.html The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 46/123 Gene Ontology BP GO:0021782 0.071678753996892 0.158445571591463 2045 2342.36363636364 2142 0.0067387769949394 1063 1.31787879714348 1.1817781444396 1 4.00255926259497 2041 1219 2142 1542 1141 4205 3213 4344 1063 2224 2632 2009 M16528 GO_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCONEOGENESIS.html Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. 28/84 Gene Ontology BP GO:0006111 0.0833150317144334 0.158445571591463 1705 1911.81818181818 2143 0.00787712174763626 538 1.5186173000057 1.5186173000057 1 4.6122266734128 1703 1025 1825 2143 3274 2330 2266 1142 2259 2525 538 2010 M13765 GO_REGULATION_OF_GROWTH_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. 5/17 Gene Ontology BP GO:0060123 0.00266770405103432 0.0161083144290426 2425 1915 2144 0.000267091196248196 61 2.19775722972283 2.19775722972283 1 14.9573653947063 2421 2144 4131 621 3137 3296 2916 171 61 1199 968 2011 M14906 GO_URATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. 6/18 Gene Ontology BP GO:0046415 0.000190640461896742 0.00237941845318971 925 1998.72727272727 2144 1.90656818575235e-05 19 0.648828184364399 0.648828184364399 1 6.46134359321686 924 2442 4314 2144 3847 274 117 323 3455 4127 19 2012 M11356 GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 10/23 Gene Ontology BP GO:0060390 0.000854018883137551 0.00723578407738622 4465 2360.27272727273 2145 7.76682350321533e-05 83 1.19859715498945 -1.38975139692581 -1 9.73864708057508 4461 972 1138 828 83 4619 4600 2701 2145 720 3696 2013 M16077 GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 386/855 Gene Ontology BP GO:1903827 0.0474325634349927 0.11808546489473 3525 2333.81818181818 2145 0.00440792689658253 908 1.20803329364144 1.33756771748403 1 4.25443769175938 3524 1916 2145 2025 943 1364 3898 2729 2537 908 3683 2014 M10871 GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. 85/179 Gene Ontology BP GO:0035567 0.0839184282471183 0.158445571591463 2770 2206.90909090909 2146 0.00793650793650794 838 1.44957803256628 1.65572128128691 1 4.40254596530547 3162 1212 2767 1671 3713 839 3307 2769 838 1852 2146 2015 M14112 GO_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. 7/25 Gene Ontology BP GO:0019433 0.203366763845006 0.311319447587327 895 2502.54545454545 2146 0.0224795715384054 895 0.656078146980424 0.888978351704546 1 1.26210083085341 895 3222 4189 3566 2146 1430 1752 1245 3562 3926 1595 2016 M12206 GO_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_FORMATION.html The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. 17/47 Gene Ontology BP GO:0048645 0.00390771479968449 0.0211216761524273 4280 2520.81818181818 2147 0.000355879375017565 473 1.38975139692581 -1.38975139692581 -1 8.83750315428168 4280 1235 473 879 937 4036 4511 3640 2032 2147 3559 2017 M14169 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. 10/21 Gene Ontology BP GO:0045986 0.00443597125391307 0.0231158412254976 1085 1955 2147 0.000404085550735634 95 0.858982002181133 0.858982002181133 1 5.33455951272939 1083 3153 1995 3215 2430 941 95 2221 2147 3935 290 2018 M16940 GO_REGULATION_OF_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of T cell migration. 15/35 Gene Ontology BP GO:2000404 0.0839184282471183 0.158445571591463 3265 2289 2147 0.00793650793650794 347 1.22779392099841 -0.989745402399581 -1 3.72896046410786 3264 888 961 1125 2147 4523 3260 2453 347 2088 4123 2019 M12682 GO_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 51/115 Gene Ontology BP GO:0051983 0.312559972565403 0.429735253959481 1710 2169.27272727273 2148 0.0334970919199191 821 1.24626748550355 -1.00419156262766 -1 1.73518849169404 1708 2523 2430 2047 3208 821 1748 2148 3215 2346 1668 2020 M13846 GO_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T cell differentiation. 51/190 Gene Ontology BP GO:0045580 0.129649257012193 0.225538216675764 3465 2601.63636363636 2148 0.0125442023333851 1274 1.50647495968082 1.50647495968082 1 3.69850010122985 3461 1274 1306 2148 1455 4148 3481 3733 1589 1555 4468 2021 M15417 GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. 77/211 Gene Ontology BP GO:1990267 0.00662786641585794 0.0304383617891478 2960 2504.54545454545 2149 0.000604356235745092 533 1.512168990702 1.80280536955425 1 8.70507502367429 2956 1631 533 1866 3644 3326 3830 2149 2128 1652 3835 2022 M15524 GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. 39/105 Gene Ontology BP GO:0007422 0.0381953285731233 0.101367005767178 495 1751.45454545455 2149 0.00353409426249678 341 1.09100576722476 -0.967459383376804 -1 4.11685744216265 493 2415 2149 3290 831 489 341 2280 3298 2661 1019 2023 M15278 GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. 127/372 Gene Ontology BP GO:0071824 0.0310744590432054 0.0884602779507067 185 1924.45454545455 2150 0.00286565987753167 184 1.36092924391204 -1.2451718004747 -1 5.4409526487784 184 2989 2150 2935 2696 945 1890 1244 2307 2539 1290 2024 M14605 GO_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/46 Gene Ontology BP GO:0051955 0.0157650457530924 0.0560467897638653 1195 1980.81818181818 2151 0.00144356031670338 396 1.38933387508025 1.38933387508025 1 6.59974417013414 1194 1386 1850 1040 3428 2930 2995 396 2173 2246 2151 2025 M12811 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. 3/15 Gene Ontology BP GO:0048934 0.252893670887669 0.36670372077809 1915 2502.72727272727 2154 0.0287338760924926 1199 0.478075287885268 0.478075287885268 1 0.790634604653802 1915 1199 3963 3127 2980 2154 1250 1352 4024 3579 1987 2026 M14921 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT.html Any process that activates or increases the frequency, rate or extent of protein import. 82/215 Gene Ontology BP GO:1904591 0.232850105696956 0.342669743502683 2245 2460.45454545455 2154 0.0238095238095238 844 1.43645297618732 1.44579329203962 1 2.5361072664805 4288 2154 1739 1887 2245 2242 4013 2045 1812 844 3796 2027 M14953 GO_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 17/46 Gene Ontology BP GO:0010226 0.014088951071273 0.0522901677249564 2110 2173 2154 0.00128909045518158 616 1.16832188465023 1.35603070540226 1 5.68349460914478 2107 2498 616 1679 1000 3483 2456 3965 1765 2154 2180 2028 M10164 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 7/24 Gene Ontology BP GO:0051968 0.0765897756730953 0.158445571591463 170 2054.45454545455 2155 0.00793650793650794 166 1.51935086267539 -1.51935086267539 -1 4.61445459305512 3800 668 3547 166 2155 2313 4634 2201 166 1392 1557 2029 M14140 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 3/15 Gene Ontology BP GO:0048935 0.250694001985381 0.364310563761541 1920 2555.81818181818 2155 0.0284482890959223 1200 0.478075287885268 0.478075287885268 1 0.795794783038286 1916 1200 4191 3128 2981 2155 1251 1349 4025 3930 1988 2030 M15194 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 17/29 Gene Ontology BP GO:1902253 0.0744110296224561 0.158445571591463 2815 2174.09090909091 2155 0.00700489773959722 329 2.31622896548935 2.31622896548935 1 7.03467095789196 2811 2968 2344 927 1160 4323 3342 1899 329 2155 1657 2031 M14202 GO_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of endocytosis. 131/321 Gene Ontology BP GO:0030100 0.00103448655387673 0.00822452237953707 1160 1816.63636363636 2156 9.40884828920514e-05 380 1.45592962034084 1.47726034642563 1 11.5220728290151 1160 2615 380 2156 3176 3165 2202 1120 1036 491 2482 2032 M10354 GO_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_GASEOUS_EXCHANGE.html The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. 29/68 Gene Ontology BP GO:0007585 0.00849631340435104 0.0363579568077437 2975 2170.54545454545 2157 0.000775391304025511 265 1.46392850079221 0.913392149381126 1 7.99850380123253 2975 265 557 1202 2157 3889 2944 3683 887 1559 3758 2033 M13727 GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 48/103 Gene Ontology BP GO:0042451 0.0150212297396349 0.0542329468749027 1845 2246.63636363636 2158 0.00137498030877061 492 0.648828184364399 0.648828184364399 1 3.11731251920107 1841 2158 3448 2699 492 984 2692 2917 1636 3819 2027 2034 M14785 GO_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-8 secretion. 10/21 Gene Ontology BP GO:2000482 0.0152155841688671 0.0546372446218484 2730 2073.81818181818 2158 0.0013928952870128 496 1.46584243959724 1.46584243959724 1 7.02473208743823 2730 1498 755 2158 496 3154 1154 3235 2755 1706 3171 2035 M14432 GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is increased. 14/50 Gene Ontology BP GO:0045777 0.302674901118576 0.417752546341721 1600 2599.45454545455 2159 0.0322418327057833 1596 0.854118486601835 0.854118486601835 1 1.22901518650806 1596 3060 2154 3767 2001 2159 1878 2606 3650 4013 1710 2036 M15576 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. 17/37 Gene Ontology BP GO:0050961 0.161385165508919 0.258740097879113 3020 2273.72727272727 2159 0.0158730158730159 1127 1.31394404283802 1.31394404283802 1 2.92835014763378 3017 1901 1265 1945 2268 4152 1127 2768 1390 2159 3019 2037 M15931 GO_MELANOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. 11/30 Gene Ontology BP GO:0030318 0.100182732203277 0.182697731979503 3005 2148.90909090909 2159 0.00955078710542946 912 2.24458518468169 2.24458518468169 1 6.29008750970058 3002 3398 912 2555 2477 2910 2159 1337 1464 1817 1607 2038 M16242 GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 48/103 Gene Ontology BP GO:0046129 0.0150212297396349 0.0542329468749027 1845 2302.09090909091 2159 0.00137498030877061 493 0.648828184364399 0.648828184364399 1 3.11731251920107 1842 2159 3449 2700 493 985 2693 2887 1637 4450 2028 2039 M10942 GO_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. 23/56 Gene Ontology BP GO:0046632 0.0839184282471183 0.158445571591463 2255 2027.63636363636 2160 0.00793650793650794 689 1.31105205751639 1.40450504596788 1 3.98182561850862 2252 2964 1405 2527 4347 2160 1930 958 689 708 2364 2040 M11231 GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS.html The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 49/987 Gene Ontology BP GO:0007606 0.0301748664336351 0.0866967232991138 990 1978.72727272727 2160 0.00278153329412419 603 1.32266079550056 1.4128867569383 1 5.33186483500431 987 2558 712 2427 3932 2867 2201 1492 1827 603 2160 2041 M12846 GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. 29/60 Gene Ontology BP GO:0042398 0.0258271790788771 0.0784650926624202 1335 2198 2160 0.00237595084708838 166 0.874649861425705 -0.874649861425705 -1 3.66970259865598 1334 3421 2160 3809 3985 166 608 2111 2699 3586 299 2042 M13775 GO_VOCALIZATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOCALIZATION_BEHAVIOR.html The behavior in which an organism produces sounds by a mechanism involving its respiratory system. 7/36 Gene Ontology BP GO:0071625 0.18571830966226 0.289748021425361 2000 2456.09090909091 2160 0.0203352832211529 815 1.51935086267539 -1.51935086267539 -1 3.10263760314847 1999 3792 4132 1466 2425 1999 2160 3729 3085 1415 815 2043 M15651 GO_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a T cell. 17/50 Gene Ontology BP GO:0002456 0.286954272649608 0.405573495018275 2065 2023.27272727273 2160 0.0302784774023327 923 1.17181367894184 1.17181367894184 1 1.74331065113456 2063 2497 1388 2554 1955 2273 923 2232 3169 2160 1042 2044 M13909 GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. 5/31 Gene Ontology BP GO:0045624 0.00191961667129023 0.0125841624771701 875 1987.36363636364 2162 0.000192127690776436 64 0.550583353676964 0.681805086703034 1 3.97122106865607 875 2518 4154 2162 3243 564 64 1117 2481 3870 813 2045 M11258 GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 22/46 Gene Ontology BP GO:1900739 0.00136262406355562 0.00969112621539502 2165 1963.81818181818 2163 0.000123951706437459 112 1.39934214282505 -0.554099100968402 -1 10.6957169430697 2163 1230 2258 2049 112 2901 1973 2432 2390 2353 1741 2046 M13588 GO_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that modulates the frequency, rate or extent of muscle hypertrophy. 23/55 Gene Ontology BP GO:0014743 0.074780881862402 0.158445571591463 2390 2246.27272727273 2163 0.00704097581796097 807 0.900416075626817 0.900416075626817 1 2.73467386487082 1648 2163 2389 2388 3505 1792 866 807 3286 3781 2084 2047 M11661 GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 22/46 Gene Ontology BP GO:1900740 0.00136262406355562 0.00969112621539502 2165 1964.90909090909 2164 0.000123951706437459 113 1.39934214282505 -0.554099100968402 -1 10.6957169430697 2164 1231 2259 2050 113 2902 1974 2433 2391 2355 1742 2048 M14798 GO_SOMATIC_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_DIVISION.html The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. 12/39 Gene Ontology BP GO:0048103 0.466738071388703 0.580826820010117 2165 2340.72727272727 2165 0.0555555555555556 1569 1.65735694990685 1.65735694990685 1 1.48439475295824 2165 3637 1569 2742 3008 2484 2129 1861 2476 1882 1795 2049 M15490 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN.html The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. 10/41 Gene Ontology BP GO:0003081 0.0839184282471183 0.158445571591463 2235 2400.63636363636 2166 0.00793650793650794 243 0.451448016498503 0.435402805638679 1 1.37110289943164 2233 1185 2565 1560 4324 2166 2096 4122 243 4292 1621 2050 M15500 GO_POSITIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 548/1446 Gene Ontology BP GO:0051050 0.149325760929203 0.251020821142032 1810 2427.27272727273 2166 0.0160425277771834 990 1.32183517026245 1.4842161294737 1 3.01193660462222 1808 3032 4415 2166 1584 3287 2728 1496 2093 990 3101 2051 M16233 GO_REGULATION_OF_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. 20/51 Gene Ontology BP GO:0060306 0.295307843694212 0.413174493778819 1485 2071.09090909091 2166 0.031316801621776 640 1.39024051586687 -1.28127221255727 -1 2.02571050762272 1482 2166 1414 1603 3011 2713 3188 1530 2229 640 2806 2052 M12876 GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-8 production. 44/109 Gene Ontology BP GO:0032677 0.298735036746822 0.413174493778819 3995 2455 2168 0.0317460317460317 515 1.38114177468899 1.38114177468899 1 2.01245279041376 3991 515 1233 1585 2040 2643 3016 3634 2031 2168 4149 2053 M10674 GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 28/65 Gene Ontology BP GO:0009247 0.161385165508919 0.258740097879113 3410 2287.27272727273 2169 0.0158730158730159 401 0.946863186450032 -0.946863186450032 -1 2.11024736317999 3410 401 2677 2169 4505 1808 1214 1853 1597 3070 2456 2054 M10982 GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 13/54 Gene Ontology BP GO:0090184 0.0839184282471183 0.158445571591463 4315 2181.72727272727 2169 0.00793650793650794 118 1.92813915692175 -1.38916827744188 -1 5.85599469309696 4312 118 906 144 2169 3576 4142 4175 135 870 3452 2055 M16855 GO_STEROID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 13/65 Gene Ontology BP GO:0006706 0.316174419993146 0.434318885215437 1985 2317.72727272727 2169 0.0339601737566919 904 0.555409895601913 0.649876348477633 1 0.763587555019533 1984 1178 1471 1950 3316 2304 904 2169 2365 4610 3244 2056 M10061 GO_L_PHENYLALANINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. 7/12 Gene Ontology BP GO:0006558 0.0199286843923507 0.0658568552552914 1735 2086.27272727273 2170 0.00201096918029728 126 1.93847904430292 1.93847904430292 1 8.69290522215744 1735 3863 3528 2728 3244 2170 2261 470 126 1389 1435 2057 M15265 GO_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. 92/251 Gene Ontology BP GO:0034341 0.00652342186793936 0.0301076021201217 2845 2415.27272727273 2170 0.00059480415876503 531 1.60289662011316 1.75618442454155 1 9.25623586930065 2843 2554 531 2258 1845 4559 2170 1892 1819 2046 4051 2058 M13543 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 7/12 Gene Ontology BP GO:1902222 0.0125983650923733 0.0479972625749175 1740 2131.54545454545 2171 0.00126703636958991 127 1.93847904430292 1.93847904430292 1 9.70380043896005 1736 3864 4094 2729 3245 2171 2262 372 127 1411 1436 2059 M14311 GO_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PIGMENTATION.html The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. 22/53 Gene Ontology BP GO:0048066 0.153507254146558 0.256656168888178 3065 2314.81818181818 2171 0.0150361426682567 1076 1.59317129651972 1.59317129651972 1 3.57189478234447 3064 1967 1557 2171 3341 3204 1884 1076 1535 2360 3304 2060 M16360 GO_CELLULAR_GLUCURONIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCURONIDATION.html The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. 3/23 Gene Ontology BP GO:0052695 0.0765897756730953 0.158445571591463 1935 2104.36363636364 2171 0.00793650793650794 47 0.761485686432955 0.839639915296995 1 2.31272526280385 1934 165 4552 317 1487 3203 2247 2171 47 4481 2544 2061 M11813 GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response. 5/23 Gene Ontology BP GO:0016056 0.168996123020861 0.269176329051752 1830 2474.54545454545 2172 0.0183417857467239 1194 1.02401096892853 1.02401096892853 1 2.21543292383972 1829 1295 3810 2172 1669 3172 3011 4197 2813 1194 2058 2062 M16112 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 7/12 Gene Ontology BP GO:1902221 0.0193492252711376 0.0645855161278877 1740 2180.09090909091 2172 0.00195197959096941 128 1.93847904430292 1.93847904430292 1 8.7551982051666 1737 3865 4510 2730 3246 2172 2263 463 128 1430 1437 2063 M10346 GO_LUNG_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_EPITHELIUM_DEVELOPMENT.html The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. 18/43 Gene Ontology BP GO:0060428 0.0011274121323704 0.0084292665549046 2175 2409.63636363636 2173 0.000102544572809611 101 1.29829314601985 -1.29829314601985 -1 10.2219267297212 4137 1388 2006 2173 101 3998 2171 3207 953 2185 4187 2064 M11274 GO_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORT.html The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 60/215 Gene Ontology BP GO:0006836 0.298735036746822 0.413174493778819 4085 2463.72727272727 2173 0.0317460317460317 857 1.46464443769764 -1.4227640217421 -1 2.1341239832436 4085 2804 1932 3073 2173 857 3177 3586 2100 1167 2147 2065 M12597 GO_DNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS.html The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 15/30 Gene Ontology BP GO:0006308 0.0105477225613173 0.0421138980071201 855 1980.45454545455 2173 0.000963512257145619 92 0.333472480554793 -0.413179304399693 -1 1.74121085565043 853 2173 2588 3310 3668 92 178 1314 3783 3533 293 2066 M16388 GO_L_PHENYLALANINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. 7/12 Gene Ontology BP GO:0006559 0.019491488432564 0.0648273501378186 1740 2185.36363636364 2173 0.00196645923450653 129 1.93847904430292 1.93847904430292 1 8.74325493999179 1738 3866 4556 2731 3247 2173 2264 465 129 1432 1438 2067 M16434 GO_PROTEIN_O_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. 44/116 Gene Ontology BP GO:0006493 0.0998762703541769 0.18221042171098 3540 2536.63636363636 2173 0.00952012553486949 1094 1.11744366472201 -1.0180746495426 -1 3.13637546715905 3538 1094 1959 1113 1309 3539 3788 3034 1751 2173 4605 2068 M11291 GO_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. 14/27 Gene Ontology BP GO:0055075 0.161385165508919 0.258740097879113 3870 2538.72727272727 2174 0.0158730158730159 418 1.2016770185941 -1.10784859035102 -1 2.67814378699693 3867 418 2174 1124 4336 3972 3434 2024 1287 911 4379 2069 M10701 GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that modulates the activity of a monooxygenase. 38/91 Gene Ontology BP GO:0032768 0.118717309764009 0.210142763718754 1960 2108.72727272727 2175 0.0114230584700403 1128 1.21455215107271 1.21455215107271 1 3.1233700521841 1958 2486 1672 2857 1399 2782 1143 1128 2949 2647 2175 2070 M11164 GO_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 13/34 Gene Ontology BP GO:0010874 0.165638054958881 0.264280924114806 1220 1996.81818181818 2175 0.0163277768643781 631 0.387388368112963 0.520936965575766 1 0.849830257721817 1219 2175 2195 2469 2196 1840 631 1136 3467 3182 1455 2071 M16011 GO_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). 117/281 Gene Ontology BP GO:0046777 0.161385165508919 0.258740097879113 2815 2544.45454545455 2175 0.0158730158730159 1512 1.45572979846953 1.62062324300487 1 3.24434407501914 2812 1512 2678 1976 2175 3232 3943 2034 1561 2003 4063 2072 M16193 GO_PROTEIN_TETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TETRAMERIZATION.html The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. 78/176 Gene Ontology BP GO:0051262 0.174709803625502 0.275520425254517 1340 2176.27272727273 2176 0.0173049020139093 684 0.375913645535363 -0.392952118037737 -1 0.798847823726691 1336 2244 2264 3406 1632 684 2176 2392 2137 4439 1229 2073 M14259 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. 14/47 Gene Ontology BP GO:0010574 0.0839184282471183 0.158445571591463 4090 2300.81818181818 2177 0.00793650793650794 287 1.21693894800114 1.21693894800114 1 3.69599258207534 4086 287 991 425 2177 3112 4373 3467 854 918 4619 2074 M16139 GO_RENAL_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_FILTRATION.html A renal system process in which fluid circulating through the body is filtered through a barrier system. 3/13 Gene Ontology BP GO:0097205 0.460796172473535 0.580433160280689 1790 2459 2177 0.0598973072587454 987 0.680985546725768 0.910960856433382 1 0.610678836292536 1788 987 4517 2474 2628 1798 1213 2131 2911 4425 2177 2075 M12758 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of cellular response to hypoxia. 10/15 Gene Ontology BP GO:1900037 0.0048218642157441 0.0245750994003292 3700 2096.72727272727 2178 0.000439315010045734 251 0.434983066130367 -0.509105062208813 -1 2.65749119984655 3696 2178 2720 1833 251 1265 2480 696 3001 3570 1374 2076 M13847 GO_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). 115/553 Gene Ontology BP GO:0002250 0.00174722512529708 0.0117400379981973 1270 2098 2178 0.000158964936773746 415 1.16246567703843 1.19078304142428 1 8.51763532144331 1267 2911 415 2178 1995 2906 1692 2288 2975 1977 2474 2077 M13825 GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 20/39 Gene Ontology BP GO:0009262 0.201261208348671 0.30861876712258 745 2263.27272727273 2179 0.0202219471135026 718 0.55936453995665 -0.55936453995665 -1 1.08408660400791 742 2815 3144 3314 1726 718 1708 2179 3675 3842 1033 2078 M11421 GO_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXON_GUIDANCE.html Any process that modulates the frequency, rate or extent of axon guidance. 15/47 Gene Ontology BP GO:1902667 0.0912994818634397 0.169155424697506 1495 2344.45454545455 2180 0.00866584252171682 890 1.31853882585007 1.31853882585007 1 3.86239398583961 1492 1737 890 2180 3949 3133 2078 3274 3389 960 2707 2079 M14007 GO_MICROTUBULE_BUNDLE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BUNDLE_FORMATION.html A process that results in a parallel arrangement of microtubules. 45/140 Gene Ontology BP GO:0001578 0.0207321978461713 0.0675425550530398 2055 1943.27272727273 2181 0.00190274450264718 145 1.09742004367719 -0.787310882461167 -1 4.87554070355847 2052 2917 2608 2988 2242 145 1725 1744 2292 2181 482 2080 M15722 GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. 120/298 Gene Ontology BP GO:0090257 0.00681362388566899 0.0309849713037817 2430 2441.54545454545 2181 0.000621347120658896 536 1.416397931272 1.28975548482727 1 8.11219283874727 2426 2592 536 2090 2181 4508 2177 4512 1510 804 3521 2081 M12929 GO_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BINDING.html Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 64/163 Gene Ontology BP GO:0051101 0.00108027555681443 0.00830040181453953 2185 2161.81818181818 2182 9.82551249235491e-05 99 1.48858961324099 1.48858961324099 1 11.7580041724846 2182 1681 2176 1941 99 3355 2327 2533 1548 2548 3390 2082 M13996 GO_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 19/41 Gene Ontology BP GO:0071887 0.00833547354005181 0.0360350127062016 1410 1989.45454545455 2182 0.000760656723385345 341 1.86280643978199 1.86280643978199 1 10.2052617238028 1410 2598 1102 2182 341 2207 2696 2170 3324 2244 1610 2083 M14840 GO_STRIATED_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_PROLIFERATION.html The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. 13/29 Gene Ontology BP GO:0014855 0.00973055713155927 0.0396654756469093 1680 2199.72727272727 2183 0.000888533054153698 309 1.08918898596586 1.08918898596586 1 5.79469572093793 1680 2678 2120 2659 3952 2498 1807 309 2355 1956 2183 2084 M15739 GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 13/55 Gene Ontology BP GO:0010866 0.0511355237267581 0.1246965528694 1790 1966.63636363636 2184 0.00476038758074271 813 1.51400851384581 1.51400851384581 1 5.19605690417695 1787 2749 813 1779 978 2771 2286 2251 3149 886 2184 2085 M10568 GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/97 Gene Ontology BP GO:0032890 0.0351637212541266 0.0959254746080552 1325 2067 2185 0.00324896985292628 581 1.38933387508025 1.38933387508025 1 5.368955547141 1321 1375 1854 1016 3332 3080 2897 581 2185 2586 2510 2086 M14858 GO_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a second cell of the identical type via adhesion molecules. 40/108 Gene Ontology BP GO:0034109 0.040816546159109 0.106287842858521 3670 2497.27272727273 2186 0.00378128064674501 750 1.83050239792877 1.83050239792877 1 6.76426803785394 3668 2098 750 2086 3647 2280 3633 2186 1498 1218 4406 2087 M16620 GO_ALCOHOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 31/86 Gene Ontology BP GO:0046164 0.214187529358772 0.322775948981753 1280 2119.72727272727 2187 0.0216741297847706 731 1.82051220676583 1.82051220676583 1 3.39367093348117 939 2962 1280 2936 4088 2361 731 1278 1990 2565 2187 2088 M15219 GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. 9/22 Gene Ontology BP GO:0010310 0.00344692602525931 0.019316501525172 2415 1998.63636363636 2189 0.000345228431094511 139 1.14672566625037 1.14672566625037 1 7.46097706538995 2412 139 4372 531 215 3661 2467 2189 1250 1620 3129 2089 M15466 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. 104/264 Gene Ontology BP GO:0031110 0.0793396078939684 0.158445571591463 1325 2498.90909090909 2189 0.0074867471773563 316 0.713988690418047 -0.713988690418047 -1 2.16847107056297 1322 3936 2189 3756 4018 316 1802 1233 3945 4284 687 2090 M16290 GO_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of dendrite development. 76/194 Gene Ontology BP GO:0050773 0.225211696940829 0.3375267620711 1300 2171.18181818182 2189 0.0229298797883906 1299 1.57914678242171 1.57914678242171 1 2.82740515248612 1299 2286 1950 2762 1793 3458 1581 2202 2096 2267 2189 2091 M11676 GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION.html Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. 18/49 Gene Ontology BP GO:0097035 0.161385165508919 0.258740097879113 1745 2267.81818181818 2190 0.0158730158730159 1454 1.30774781221536 1.30774781221536 1 2.91454078264701 1741 2599 1538 2245 4421 2293 1860 1741 1454 2190 2864 2092 M10241 GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 8/21 Gene Ontology BP GO:0051532 0.0367654242331895 0.0986203392393756 2200 2174.90909090909 2197 0.00373882395767719 717 0.408762582963613 -0.244047069726719 -1 1.56095654053557 2197 1504 3558 1687 863 2830 2891 717 1953 2984 2740 2093 M16621 GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. 11/24 Gene Ontology BP GO:0043011 0.28469859691192 0.403355459704702 2785 2388.90909090909 2197 0.03 426 0.653874098340854 0.653874098340854 1 0.978681604966235 2785 426 2474 1092 1987 1673 1995 4488 2197 4547 2614 2094 M14844 GO_STEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 8/19 Gene Ontology BP GO:0016127 0.329386251808755 0.449673733357262 1455 2366.63636363636 2198 0.0391684719517381 833 0.734618950670482 0.777753013412624 1 0.967892389693774 1451 833 4302 1076 4342 2198 1173 1491 2341 4110 2716 2095 M16716 GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. 34/88 Gene Ontology BP GO:0009185 0.020579955834528 0.0671960161320068 3585 2224.18181818182 2198 0.00188863919617036 592 1.34356065686401 1.50049685841841 1 5.980469980708 3584 1158 2212 1237 592 1341 4178 4246 2198 1034 2686 2096 M15450 GO_CHOLESTEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 8/19 Gene Ontology BP GO:0006707 0.330377527925878 0.4507619342227 1455 2392.54545454545 2199 0.0393105930290895 834 0.734618950670482 0.777753013412624 1 0.964965271533128 1452 834 4408 1077 4343 2199 1174 1495 2342 4277 2717 2097 M12508 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that activates or increases the frequency, rate or extent of response to oxidative stress. 10/22 Gene Ontology BP GO:1902884 0.0839184282471183 0.158445571591463 2390 2129.18181818182 2200 0.00793650793650794 195 0.47872042730141 -0.219964126654929 -1 1.45393255016576 2389 1864 2200 1536 1281 2670 2967 1606 195 3508 3205 2098 M16799 GO_RESPONSE_TO_LEPTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEPTIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. 11/27 Gene Ontology BP GO:0044321 0.398240446985387 0.519536497710917 2195 2414.81818181818 2201 0.0451227533266938 1652 0.422438897449744 0.555395618352892 1 0.456011919440239 2267 1980 2194 2238 2194 2631 1652 1858 2753 4595 2201 2099 M14359 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. 24/59 Gene Ontology BP GO:0060760 0.190846319333326 0.296950221402357 2885 2341.27272727273 2203 0.0190673658676456 749 1.49674653232731 1.49674653232731 1 2.99589595209444 2882 2632 1441 2193 2312 4626 1970 1179 2203 749 3567 2100 M12028 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. 38/82 Gene Ontology BP GO:1904377 0.0839184282471183 0.158445571591463 2315 2420.54545454545 2205 0.00793650793650794 1054 1.27686276702898 1.15561871920577 1 3.87798855729736 2312 2205 1760 1377 1801 3832 2919 3887 1054 1991 3488 2101 M14286 GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE.html Any process in by an organism or tissue maintains a population of neuronal stem cells. 18/36 Gene Ontology BP GO:0097150 0.121696041238486 0.214190568411786 3280 2260.09090909091 2205 0.0117272884882218 973 1.16186250822327 -1.16186250822327 -1 2.95132936063481 3279 1284 1903 1322 2322 1637 4642 973 2956 2205 2338 2102 M11016 GO_RESPONSE_TO_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANGIOTENSIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. 13/29 Gene Ontology BP GO:1990776 0.0839184282471183 0.158445571591463 3025 2542.36363636364 2206 0.00793650793650794 840 0.567425314793014 -0.527657516729054 -1 1.72334015415198 3023 1797 1273 1832 3357 2206 3964 4336 840 3142 2196 2103 M11056 GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION.html The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. 4/18 Gene Ontology BP GO:0048505 0.104005561972069 0.188558307003639 2210 2370.45454545455 2206 0.0109220241652773 945 0.546161110836939 0.589786896912179 1 1.50210039478796 2206 1462 3678 2310 3942 2691 1634 945 2153 3152 1902 2104 M14254 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. 38/82 Gene Ontology BP GO:1903078 0.0839184282471183 0.158445571591463 2315 2423.09090909091 2206 0.00793650793650794 1055 1.27686276702898 1.15561871920577 1 3.87798855729736 2313 2206 1761 1378 1802 3833 2920 3901 1055 1996 3489 2105 M11273 GO_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_PROCESS.html A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. 11/21 Gene Ontology BP GO:0003016 0.0152306265542645 0.0546489946610897 3330 2549.09090909091 2207 0.00139428198065996 498 1.98725977860331 -3.11553755502548 -1 9.52280718821379 3327 1121 995 2207 498 4472 4302 3325 2160 1779 3854 2106 M12025 GO_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENTATION.html The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. 47/105 Gene Ontology BP GO:0043473 0.113580106063304 0.202516295104424 3005 2250.18181818182 2207 0.0109005644271074 1131 1.40567856173379 1.59317129651972 1 3.70053727399412 3001 1318 2605 1817 1376 1131 3420 4025 1591 2261 2207 2107 M14964 GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC.html Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. 4/18 Gene Ontology BP GO:0040034 0.0964985041973193 0.177302158681501 2210 2517.45454545455 2207 0.0100964366330153 919 0.546161110836939 0.589786896912179 1 1.55751876129444 2207 1463 4325 2311 3943 2692 1635 919 2154 4140 1903 2108 M15197 GO_GLYCEROLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. 18/46 Gene Ontology BP GO:0046503 0.0286092620382958 0.0833679666089529 935 2007.45454545455 2207 0.00263529276231649 707 1.82051220676583 1.82051220676583 1 7.45628654207247 934 3008 707 3306 1453 2319 2245 1057 2730 2207 2116 2109 M10559 GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cation channel activity. 25/56 Gene Ontology BP GO:2001259 0.0839184282471183 0.158445571591463 3980 2320.09090909091 2208 0.00793650793650794 801 1.06094041096732 -0.941440206989479 -1 3.22220592526218 3980 2208 1515 1601 2406 1690 3821 2900 801 1377 3222 2110 M12954 GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. 17/31 Gene Ontology BP GO:0045652 0.109436270924856 0.196258248707651 2135 2156.09090909091 2209 0.0104811057652075 928 0.572940564166015 -0.552606561537163 -1 1.5379489106086 2135 1902 928 2209 2434 1031 2545 2266 3148 3614 1505 2111 M14662 GO_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_ANION_GENERATION.html The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. 6/16 Gene Ontology BP GO:0042554 0.0176782517195304 0.0608698748517488 935 1904.27272727273 2209 0.00178204810185026 219 0.460395902830308 0.540096955124437 1 2.12436193962114 932 2583 4268 2464 2209 486 219 496 2625 4069 596 2112 M15318 GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY.html Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. 21/75 Gene Ontology BP GO:0034260 0.000557795153607319 0.00531795256303652 1065 1736.09090909091 2211 5.07215117295503e-05 73 1.3261771808088 -1.3261771808088 -1 11.4484856314498 1065 2211 2659 2874 4608 226 371 73 2393 2334 283 2113 M16719 GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 18/72 Gene Ontology BP GO:0060119 0.0839184282471183 0.158445571591463 2215 2218.63636363636 2211 0.00793650793650794 376 1.9555202969072 1.9555202969072 1 5.93915456767083 2211 2496 1432 2120 3524 3926 2526 1472 376 1075 3247 2114 M16947 GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. 73/199 Gene Ontology BP GO:0002700 0.0460075966612907 0.115860574033061 1175 2097.36363636364 2211 0.00427262539158317 666 1.51351096353794 1.51351096353794 1 5.37772383293552 1172 3205 1318 3550 2706 2211 1315 666 2122 2218 2588 2115 M11722 GO_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. 196/485 Gene Ontology BP GO:0016055 0.042573179636374 0.109450317304366 3630 2120.45454545455 2212 0.00394727881203836 217 1.33902795374348 1.58762085884375 1 4.88339858900656 3627 922 1935 2212 1333 217 3030 3571 2294 2583 1601 2116 M12689 GO_RESPONSE_TO_INACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. 12/23 Gene Ontology BP GO:0014854 0.0508881164116902 0.124289071278 4615 2539.72727272727 2212 0.00473679954102601 976 0.46014151469241 -0.443313331438985 -1 1.58168233446646 4615 1446 2274 1647 976 2146 2956 1935 2212 3556 4174 2117 M15362 GO_NUCLEOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPHAGY.html A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. 14/20 Gene Ontology BP GO:0044804 0.126821084579386 0.221364772820334 1705 2171.27272727273 2213 0.0122529322065455 677 0.757413120848284 -0.757413120848284 -1 1.88282259858205 2213 1701 3090 2431 1701 826 2758 988 3247 4252 677 2118 M11622 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 43/85 Gene Ontology BP GO:0007173 0.206068120351188 0.314314810377978 3475 2518.63636363636 2214 0.0207594581304091 835 1.29018372205382 1.29018372205382 1 2.46156693429191 3473 1016 1927 835 1741 3984 2867 3064 2214 2134 4450 2119 M14689 GO_DENDRITIC_SPINE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. 15/39 Gene Ontology BP GO:0097061 0.026237959138559 0.079260145920839 2690 2498.45454545455 2214 0.00241420079293037 678 1.31394404283802 1.31394404283802 1 5.49097892679357 2688 1492 2214 2029 678 3584 3529 4586 2060 2080 2543 2120 M12691 GO_SPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 73/149 Gene Ontology BP GO:0006665 0.0839184282471183 0.158445571591463 2280 1932.81818181818 2217 0.00793650793650794 1010 1.26142188782481 1.44876578490595 1 3.83109271663438 2276 1313 2337 1513 1826 1061 2442 2995 1010 2217 2271 2121 M14694 GO_COCHLEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_DEVELOPMENT.html The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. 21/75 Gene Ontology BP GO:0090102 0.0699236082960362 0.155448462133891 1765 1988.72727272727 2217 0.00656820303231736 667 1.44025656002388 1.44025656002388 1 4.41957683004319 1763 1438 842 2357 3517 2471 781 2990 2217 667 2833 2122 M15776 GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION.html The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. 11/35 Gene Ontology BP GO:0021799 0.253768878440082 0.367628362744867 1825 2562.09090909091 2217 0.0262599510162971 935 1.14672566625037 1.14672566625037 1 1.89167917251199 1823 4101 2661 3971 4374 1839 2217 1584 2864 1814 935 2123 M16065 GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. 18/26 Gene Ontology BP GO:0016601 0.279221809696782 0.396563554648148 1470 2370.72727272727 2218 0.0293271642065519 847 0.989745402399581 -0.989745402399581 -1 1.50910242954322 1468 2965 2829 2218 4110 1745 847 1456 2334 4412 1694 2124 M16971 GO_BRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). 16/55 Gene Ontology BP GO:0048854 0.0839184282471183 0.158445571591463 4405 2369.09090909091 2218 0.00793650793650794 257 1.91021908880517 1.91021908880517 1 5.80156925216492 4403 1905 1784 1682 2858 2710 2946 2218 257 1013 4284 2125 M11201 GO_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DETERMINATION.html Any process that establishes and transmits the specification of sexual status of an individual organism. 5/29 Gene Ontology BP GO:0007530 0.0842489233380105 0.15885981941382 3935 2637.18181818182 2220 0.0087624541133492 1188 1.38916827744188 -1.38916827744188 -1 4.21309471762772 3934 2186 3707 1300 1277 4622 3379 2220 1934 1188 3262 2126 M11710 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. 19/53 Gene Ontology BP GO:0036092 0.563626424374115 0.671521038842447 1690 2393.63636363636 2222 0.0726154453301721 1333 0.450101086943759 0.511510026469652 1 0.295470204054148 1687 2069 2222 1646 3689 1880 1333 2987 2832 3322 2663 2127 M11909 GO_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSPORT.html The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 104/370 Gene Ontology BP GO:0015849 0.000246454551948937 0.00281844454359339 1155 1790.45454545455 2222 2.2407469572796e-05 210 1.48035725913824 1.57775817076 1 14.3288828579588 1151 210 295 850 2232 3769 2323 2222 2034 2265 2344 2128 M14063 GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of smoothened signaling. 27/92 Gene Ontology BP GO:0008589 0.0839184282471183 0.158445571591463 4310 2216.45454545455 2222 0.00793650793650794 268 1.49480805214696 1.49480805214696 1 4.53991507255601 4306 878 1608 811 3269 2222 2475 3443 268 470 4631 2129 M10452 GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. 47/108 Gene Ontology BP GO:0050848 0.00474648692813699 0.0242708577173348 2225 2281.09090909091 2224 0.000432432589459281 248 1.05445204559117 1.15822641864813 1 6.46373733402077 2224 2096 1525 2352 248 4088 3327 1927 2130 2260 2915 2130 M16226 GO_NEGATIVE_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_SILENCING.html Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 8/26 Gene Ontology BP GO:0060969 0.0279168662543677 0.0819424213782607 3875 2501.90909090909 2224 0.00282739034514082 737 1.35593454827845 1.35593454827845 1 5.5920645171247 3874 901 4531 1413 737 1335 2224 4633 2720 1533 3620 2131 M12672 GO_HIPPOCAMPUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPOCAMPUS_DEVELOPMENT.html The progression of the hippocampus over time from its initial formation until its mature state. 46/129 Gene Ontology BP GO:0021766 0.0644929414936293 0.14678467027202 2590 2477.09090909091 2225 0.00604227053665238 1015 1.30126134143783 1.61156951470423 1 4.11607423017788 2588 1015 1459 1914 1088 4475 3098 4631 2041 2225 2714 2132 M10435 GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 10/25 Gene Ontology BP GO:0043555 0.0257320700448867 0.0784268537777523 2970 2339.45454545455 2226 0.00236709682268856 671 0.23545860963623 -0.256035002648233 -1 0.988085176554528 2968 2226 3367 2610 671 1273 1849 3979 1810 3028 1953 2133 M13557 GO_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAT_CASCADE.html An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with activation of STAT proteins by kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 25/85 Gene Ontology BP GO:0097696 0.104661745741284 0.18900991267086 4625 2423.18181818182 2227 0.01 87 0.901074887576515 1.00100121301317 1 2.47466210539895 4624 87 1774 414 2218 2227 3937 3089 1761 2442 4082 2134 M11037 GO_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMISSION_OF_NERVE_IMPULSE.html The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. 14/102 Gene Ontology BP GO:0019226 0.511063730035843 0.627050688219243 1135 2841.81818181818 2228 0.0629770995331261 1134 0.234389523683182 0.266225229287448 1 0.180340595951871 1134 4465 2182 4504 4530 1258 1463 1750 4599 3147 2228 2135 M11040 GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. 12/31 Gene Ontology BP GO:0045606 0.1092363012778 0.196051081110486 3995 2886.45454545455 2228 0.0104609087979793 931 1.33403223803043 -1.33403223803043 -1 3.58327597649235 3993 1910 2228 1935 3579 4125 4549 931 2171 1857 4473 2136 M13869 GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 53/131 Gene Ontology BP GO:0042345 0.35943518917414 0.479556776820555 3080 2500.81818181818 2228 0.0396825396825397 1262 1.09908270373103 1.32618782902959 1 1.33151485663632 3077 1365 2954 2021 2130 1262 4614 3302 2228 2383 2173 2137 M14003 GO_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE.html Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 25/85 Gene Ontology BP GO:0007259 0.104661745741284 0.18900991267086 4625 2425.45454545455 2228 0.01 88 0.901074887576515 1.00100121301317 1 2.47466210539895 4625 88 1775 415 2219 2228 3938 3104 1762 2443 4083 2138 M14064 GO_RETINA_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_LAYER_FORMATION.html The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. 10/38 Gene Ontology BP GO:0010842 0.00672857914541705 0.0307695384735218 900 1808.09090909091 2228 0.000613567880379552 172 0.792904243146179 -0.792904243146179 -1 4.55035220264874 900 2228 2614 2626 3660 172 540 262 2757 3912 218 2139 M14145 GO_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT.html Any process that modulates the frequency, rate or extent of protein import. 136/325 Gene Ontology BP GO:1904589 0.415320710913563 0.535202348257472 3025 2284.18181818182 2229 0.0476190476190476 742 1.30645422210802 1.37873979637757 1 1.34630187700888 3025 1826 1874 1416 2229 3159 2617 1608 2394 742 4236 2140 M10329 GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. 44/108 Gene Ontology BP GO:0009132 0.0102700660210314 0.0413524357861842 2975 2240.81818181818 2230 0.000938029504931831 389 1.34356065686401 1.50049685841841 1 7.05575234129409 2972 1727 2693 1657 389 1432 3665 4055 2230 1345 2484 2141 M11727 GO_SPECIFICATION_OF_ORGAN_IDENTITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_ORGAN_IDENTITY.html The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. 4/21 Gene Ontology BP GO:0010092 0.069008363758782 0.153819410913118 1555 2341.63636363636 2230 0.0071249945477471 1169 0.682677036177895 0.777679068237584 1 2.10672145450349 1553 1461 3796 1611 1169 2216 2230 2384 3236 3328 2774 2142 M16613 GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. 10/21 Gene Ontology BP GO:0034616 0.199268649250204 0.306460529469592 3245 2384.18181818182 2230 0.02 303 1.00744291305309 1.00744291305309 1 1.96414802212494 3243 303 1643 1665 2368 4459 2601 2230 1798 1724 4192 2143 M12072 GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. 20/57 Gene Ontology BP GO:0031057 0.273144180271825 0.391543201297339 2575 2542.27272727273 2232 0.0285859325766588 1852 1.13115893914357 -1.13115893914357 -1 1.74847849827247 2572 1852 2919 2149 1913 1945 4329 3660 2232 2287 2107 2144 M11175 GO_RENAL_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. 6/19 Gene Ontology BP GO:0072087 0.0765897756730953 0.158445571591463 3370 2102.09090909091 2233 0.00793650793650794 21 1.59728558834855 -1.38916827744188 -1 4.85115189694287 3366 2233 3702 354 1876 3454 3228 1518 21 496 2875 2145 M13620 GO_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 51/167 Gene Ontology BP GO:0032368 0.415320710913563 0.535202348257472 1725 2395.27272727273 2233 0.0476190476190476 1721 0.407490493780572 0.451908529053273 1 0.419919203595057 1721 2411 2046 2028 2385 2995 2104 2185 2449 3791 2233 2146 M16559 GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. 20/64 Gene Ontology BP GO:0034308 0.161385165508919 0.258740097879113 2785 2314.09090909091 2233 0.0158730158730159 545 0.995735176152667 -0.967459383376804 -1 2.21916699263422 2783 545 1501 1771 2233 2887 1862 3909 1478 2310 4176 2147 M10035 GO_LACTATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSPORT.html The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 4/13 Gene Ontology BP GO:0015727 0.0608101598692589 0.140721239830686 1435 2255.18181818182 2234 0.00625412578394115 769 0.567202248228004 -0.732984530164494 -1 1.83358650081013 1434 2234 3521 2581 4364 1277 1433 769 2618 2938 1638 2148 M13665 GO_LACTATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 4/13 Gene Ontology BP GO:0035873 0.0606839330303309 0.140721239830686 1435 2388 2235 0.00624077067624632 768 0.567202248228004 -0.732984530164494 -1 1.83358650081013 1435 2235 4112 2582 4365 1278 1434 768 2619 3801 1639 2149 M11824 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of extracellular matrix assembly. 7/16 Gene Ontology BP GO:1901201 0.147859119791321 0.249186894080256 3000 2317.18181818182 2237 0.0158730158730159 907 0.407788918927043 -0.35743514079215 -1 0.934118112089913 2999 1873 3813 2237 1859 1635 907 3042 1363 3349 2412 2150 M10044 GO_TRNA_AMINOACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_AMINOACYLATION.html The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. 33/52 Gene Ontology BP GO:0043039 0.381149031279606 0.502748565974775 1050 2659 2239 0.0426884922548138 1047 0.210637801108247 -0.238247343354841 -1 0.238783789414724 1047 4253 3455 4139 2158 1111 2239 2227 3925 2941 1754 2151 M12698 GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 165/381 Gene Ontology BP GO:0046822 0.198279602807594 0.305749649895602 3155 2451.45454545455 2240 0.0198900185265298 1055 1.30645422210802 1.37873979637757 1 2.55211317498861 3153 2240 1922 2199 1718 2981 3395 1494 2298 1055 4511 2152 M13633 GO_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIVISION.html Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. 152/381 Gene Ontology BP GO:0051302 0.0680151151269261 0.152374161760971 4470 2687 2241 0.00638305776004627 839 1.44472665120588 1.66169740922962 1 4.48086752329419 4468 2241 839 1906 2187 2138 4450 4550 2267 929 3582 2153 M14013 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of organic acid across a membrane. 40/133 Gene Ontology BP GO:1903825 0.177430838555256 0.27916346438904 2065 2340.09090909091 2241 0.0175998906439551 873 1.4836078808557 1.4836078808557 1 3.1206637525976 2062 873 1060 2241 1828 3475 3839 3338 2652 2052 2321 2154 M16731 GO_REGULATION_OF_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING.html Any process that modulates the frequency, rate or extent of protein targeting. 212/501 Gene Ontology BP GO:1903533 0.0284790450414821 0.0832671323221673 4420 2163 2241 0.00262313906079354 660 1.21321879841564 1.34288145267969 1 4.97141051222152 4419 1264 2579 1544 716 848 4342 2534 2241 660 2646 2155 M11236 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. 2/18 Gene Ontology BP GO:0045955 0.13411491204602 0.231830058313355 1930 2334.4 2242 0.0158730158730159 1237 0.518788730927493 -0.0336721261908757 -1 1.25013058802717 1926 2475 3713 NA 3005 2009 1468 1740 1237 3195 2576 2156 M13516 GO_PIGMENT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. 19/41 Gene Ontology BP GO:0050931 0.161385165508919 0.258740097879113 3515 2362.18181818182 2242 0.0158730158730159 1315 1.59317129651972 1.59317129651972 1 3.55065607766825 3512 2109 1315 1664 2366 3532 2299 1758 1515 2242 3672 2157 M13286 GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 48/104 Gene Ontology BP GO:0042158 0.013164105691295 0.0497227481741481 1220 2039.45454545455 2243 0.00120395834508933 109 0.852138153649158 -0.852138153649158 -1 4.21609036821118 1218 2593 3290 2953 2212 109 931 2243 2994 3695 196 2158 M13617 GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 19/45 Gene Ontology BP GO:0060314 0.075873954209582 0.158445571591463 2075 2464.27272727273 2243 0.00714767873300786 810 1.29994081892301 1.29994081892301 1 3.94807942648459 2074 3884 2297 3615 2119 3155 953 810 3824 2243 2133 2159 M11867 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT.html The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+. 13/52 Gene Ontology BP GO:0072488 0.298626886040032 0.413174493778819 1580 2177.72727272727 2244 0.0317324575730691 1103 1.03855172572717 1.03855172572717 1 1.51326703505054 1580 2462 1204 2631 2620 2302 2107 2244 3768 1934 1103 2160 M11933 GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. 8/17 Gene Ontology BP GO:0003161 0.0357907340688267 0.0967569299056863 2340 2112.09090909091 2244 0.00363805887827704 582 0.960990676849845 -1.07272638267715 -1 3.6999896034405 2336 1126 3828 963 848 3167 2516 4114 582 1509 2244 2161 M14486 GO_RESPONSE_TO_MUSCLE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. 19/61 Gene Ontology BP GO:0014850 0.0027579830385801 0.0164381453762868 3085 2519.54545454545 2245 0.000251040600500729 172 1.9083122944764 1.9083122944764 1 12.9237145767271 3081 1736 1400 1757 172 3810 3110 4580 1809 2245 4015 2162 M16209 GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. 22/70 Gene Ontology BP GO:2000677 0.0843691898384287 0.158979768027526 2245 2193.63636363636 2245 0.00798089502853205 1225 1.70820157422404 1.70820157422404 1 5.17853924421532 2245 1850 2286 1885 1225 2856 1733 2665 1403 2371 3611 2163 M11978 GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 113/267 Gene Ontology BP GO:0008654 0.110260520695715 0.197660076289655 3640 2564.36363636364 2247 0.0105643986711786 1365 1.26709764815467 -0.996905845581527 -1 3.38641333941031 3637 2197 2773 1552 1365 1577 4291 3841 2056 2672 2247 2164 M13650 GO_MESODERM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_MORPHOGENESIS.html The process in which the anatomical structures of the mesoderm are generated and organized. 49/111 Gene Ontology BP GO:0048332 0.125593657653559 0.219469835335143 3030 2618.63636363636 2247 0.0121267877602124 606 1.34119366288721 1.39617104943007 1 3.35302693631375 3026 2247 1460 1655 1433 4444 4050 4131 1383 606 4370 2165 M14456 GO_MONOCARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSPORT.html The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 53/209 Gene Ontology BP GO:0015718 0.00516183343558007 0.0255777936407666 1080 2009.45454545455 2247 0.00047036222870263 379 1.11199687134875 1.11199687134875 1 6.72033944600659 1077 379 503 1599 3356 2977 2128 2247 3161 2384 2293 2166 M14835 GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). 19/87 Gene Ontology BP GO:0007193 0.407948207061001 0.530264144844409 1900 2431.90909090909 2247 0.0465335250335335 1309 1.51430131785667 1.51430131785667 1 1.58362858437028 2598 1899 1309 1898 2564 3884 2165 2006 3167 2247 3014 2167 M11085 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 268/605 Gene Ontology BP GO:1903829 0.0135847088968016 0.050784060714855 3255 2340.90909090909 2248 0.00124266591616597 467 1.26247042235702 1.37835043993076 1 6.20232032680287 3253 1718 1948 1724 467 2248 3603 3134 2397 938 4320 2168 M14206 GO_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTION_POTENTIAL.html A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. 37/148 Gene Ontology BP GO:0001508 0.442964520119441 0.56193559205316 850 2439 2250 0.0518032953563496 848 1.47343464504073 1.49875549878316 1 1.39998154553137 848 3836 1637 3997 3909 1925 1702 2283 3328 1114 2250 2169 M10213 GO_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 30/102 Gene Ontology BP GO:0051339 0.271647224970605 0.389637956607513 3285 2344.63636363636 2251 0.0284042279238614 1034 1.14796226859257 -1.29245240179828 -1 1.7836830953812 3284 2251 1176 1815 2260 1034 3879 4309 2756 1643 1384 2170 M13362 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 18/39 Gene Ontology BP GO:0098901 0.39713678993857 0.51838799991138 2255 2481.90909090909 2251 0.044963677486902 962 1.13975148755868 -1.13975148755868 -1 1.2344905156102 2251 3916 1689 3189 3904 962 2455 1727 3101 2199 1908 2171 M15794 GO_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. 19/61 Gene Ontology BP GO:0030850 0.194494195109791 0.301615413458504 2205 2381.45454545455 2251 0.0194702193578806 695 1.46584243959724 1.46584243959724 1 2.89636990926817 2201 3180 1892 3192 4229 1350 695 2937 1896 2251 2373 2172 M16903 GO_PIGMENT_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_METABOLIC_PROCESS.html The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. 33/73 Gene Ontology BP GO:0042440 0.00970703637427538 0.0396043672106859 1525 2240.63636363636 2251 0.00088637573454052 376 1.44670668452304 1.44670668452304 1 7.70043592577232 2465 1523 2251 1525 376 4273 2169 3788 704 2593 2980 2173 M10603 GO_MICROTUBULE_ANCHORING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ANCHORING.html Any process in which a microtubule is maintained in a specific location in a cell. 11/22 Gene Ontology BP GO:0034453 0.238968797002156 0.350120582038817 2195 2631.27272727273 2253 0.0245199187286373 1433 0.171719250623891 -0.188421313908716 -1 0.297087053527451 2193 3640 3340 3951 1832 1571 2253 1433 4037 3057 1637 2174 M15876 GO_PLATELET_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DEGRANULATION.html The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. 62/171 Gene Ontology BP GO:0002576 0.0168984232493003 0.0589034377976735 1065 2089.45454545455 2254 0.0015481486300482 634 1.22883726602391 1.22883726602391 1 5.73663283492846 1061 1680 634 2254 3098 2552 1523 1725 3336 2534 2587 2175 M10357 GO_AMINO_ACID_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_ACTIVATION.html The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. 33/52 Gene Ontology BP GO:0043038 0.381149031279606 0.502748565974775 1050 2668.45454545455 2255 0.0426884922548138 1048 0.210637801108247 -0.238247343354841 -1 0.238783789414724 1048 4254 3456 4140 2159 1112 2240 2255 3926 3008 1755 2176 M16555 GO_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING.html Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 28/70 Gene Ontology BP GO:0060968 0.557443745451391 0.666249592815201 2115 2366.27272727273 2256 0.0714285714285714 1356 1.34498339315444 -1.33403223803043 -1 0.900392227976025 2113 2253 2210 2498 2723 1356 2933 3377 2759 1551 2256 2177 M16461 GO_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIOR.html The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 235/825 Gene Ontology BP GO:0007610 0.00310529557427791 0.0178881977064173 2260 2166.81818181818 2257 0.000282698852164616 456 1.51376494042283 1.64984850424847 1 10.040753596681 2257 2520 456 1464 1657 4138 3359 2973 1051 516 3444 2178 M10998 GO_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. 75/161 Gene Ontology BP GO:0002573 0.0276753529635444 0.0814300784599091 2400 2270.18181818182 2259 0.00254815984934781 705 1.04428540901496 1.1463806916812 1 4.31757721432175 2396 2005 1395 1591 705 4524 2445 1212 3098 2259 3342 2179 M12634 GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). 18/46 Gene Ontology BP GO:0007205 0.298735036746822 0.413174493778819 3210 2560 2259 0.0317460317460317 1032 0.995816582010741 -0.995816582010741 -1 1.45099793219339 3209 1032 1634 2259 2263 3711 3719 1676 2002 2197 4458 2180 M16686 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of hydrogen ion (proton) across a membrane. 44/121 Gene Ontology BP GO:1902600 0.237382951232347 0.348016748522825 1860 2335.18181818182 2259 0.0243353010877247 672 1.02571973280214 1.13782707616943 1 1.78476242075314 1859 2201 3381 3325 2259 672 1915 3418 2888 2699 1070 2181 M15946 GO_RESPONSE_TO_ETHER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. 8/17 Gene Ontology BP GO:0045472 0.0650925758815084 0.147211315059836 1405 2159.09090909091 2261 0.00670817568208816 633 1.35593454827845 1.35593454827845 1 4.28252571666158 1404 2082 4483 2261 1140 2455 2339 2489 2936 1528 633 2182 M12076 GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 14/34 Gene Ontology BP GO:0072529 0.172597603534238 0.273692169811976 2830 2413.36363636364 2262 0.0170765263764731 610 1.0296882537552 -1.0296882537552 -1 2.19947456806408 2830 3098 2262 3565 1616 610 1102 3870 4014 2016 1564 2183 M14597 GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS.html A biological process that directly contributes to the process of producing new individuals, involving another organism. 405/1478 Gene Ontology BP GO:0044703 0.00134638825661364 0.00968751229841395 2275 2030 2262 0.0001224739041558 397 1.33234956900403 1.4953143689441 1 10.184485821303 2271 3266 397 3405 1070 2262 2804 1653 1871 1046 2285 2184 M12566 GO_EMBRYONIC_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_FORELIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 17/50 Gene Ontology BP GO:0035115 0.0839184282471183 0.158445571591463 3685 2624.54545454545 2263 0.00793650793650794 699 1.25389438704614 1.34447838923063 1 3.80823077513224 3684 2263 1247 1809 2661 4316 4386 2228 699 1040 4537 2185 M13157 GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). 14/36 Gene Ontology BP GO:0001941 0.246302107370585 0.359164787852269 4005 2599.45454545455 2265 0.0253782068028478 1374 1.51935086267539 -1.51935086267539 -1 2.56471161569841 4002 2265 1823 1374 1849 4536 1689 3173 3020 2022 2841 2186 M16556 GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/22 Gene Ontology BP GO:0051957 0.112547003585805 0.200982976018805 1700 2726.63636363636 2266 0.0107958223422316 936 0.468582179057908 0.419934282625082 1 1.23944290007223 1698 1978 2266 1748 1677 4473 4525 936 3352 4531 2809 2187 M11905 GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 45/125 Gene Ontology BP GO:1903557 0.416490258034652 0.536560562723332 1945 2421.36363636364 2267 0.0477923933817396 1319 1.09313525943509 -0.889829409089437 -1 1.12190919453754 1944 1928 1319 2267 2500 3020 2236 1905 3255 2711 3550 2188 M16575 GO_POSITIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXONOGENESIS.html Any process that activates or increases the frequency, rate or extent of axonogenesis. 46/107 Gene Ontology BP GO:0050772 0.261898370201322 0.377990094138869 1620 2432.36363636364 2268 0.0272291224223495 1618 1.17628946726973 1.17628946726973 1 1.88654982719965 1618 2248 2425 2056 1888 2904 2268 4037 2443 2721 2148 2189 M13420 GO_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a protein. 447/1131 Gene Ontology BP GO:0006468 0.0839184282471183 0.158445571591463 3385 2473.63636363636 2269 0.00793650793650794 1191 1.35791536404425 1.52343731116495 1 4.1241552181909 3138 1412 2983 2201 1485 1723 3384 3382 1191 2269 4042 2190 M10234 GO_NUCLEOTIDE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. 28/76 Gene Ontology BP GO:0046939 0.161385165508919 0.258740097879113 4490 2743.36363636364 2270 0.0158730158730159 1493 1.50049685841841 1.50049685841841 1 3.34411516293791 4490 1525 2270 1691 1817 2420 4534 4459 1493 1544 3934 2191 M10347 GO_METENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. 58/189 Gene Ontology BP GO:0022037 0.0785328314906652 0.158445571591463 3545 2174.36363636364 2270 0.0074077112722145 759 1.39451920644617 -1.09772429375253 -1 4.23532556919467 3545 3677 857 2057 1219 1191 3218 2586 2270 759 2539 2192 M12293 GO_ANDROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 10/34 Gene Ontology BP GO:0006702 0.161385165508919 0.258740097879113 3950 2547.72727272727 2271 0.0158730158730159 1321 1.38916827744188 -1.38916827744188 -1 3.09600028442755 3949 2684 2372 2083 2208 3086 1924 2271 1321 1689 4438 2193 M11972 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. 55/145 Gene Ontology BP GO:0002718 0.0117541164958747 0.045592617285168 1955 2248.09090909091 2273 0.00107430817677464 345 1.51351096353794 1.51351096353794 1 7.70470008860463 1955 3313 1067 2926 2469 3456 2151 345 2273 1732 3042 2194 M16341 GO_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 42/169 Gene Ontology BP GO:0030814 0.00157823767859628 0.0108881984275223 2275 2142.45454545455 2273 0.000143579183123306 406 1.17182040113741 1.22440804632027 1 8.73169010605658 2273 1522 406 1951 2571 4177 1834 2420 2706 1281 2426 2195 M12936 GO_RESPONSE_TO_ISCHEMIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISCHEMIA.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. 23/46 Gene Ontology BP GO:0002931 0.126885763517685 0.221394438185875 2320 2011.45454545455 2277 0.012259583824991 1050 2.24458518468169 2.24458518468169 1 5.57922755754641 2320 2456 1780 2277 1441 2533 1050 1356 2621 2391 1901 2196 M13124 GO_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that modulates the frequency, rate, or extent of mast cell activation. 25/56 Gene Ontology BP GO:0033003 0.417357476227334 0.537081696819155 1330 2358.45454545455 2279 0.0479211331717375 1073 0.905815316330878 -0.664904966411386 -1 0.928208932558781 1326 3949 2279 3816 2504 1778 1073 1974 3290 2441 1513 2197 M16641 GO_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOLYSIS.html The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. 558/1543 Gene Ontology BP GO:0006508 0.0211708096930289 0.0682611593088426 3780 2321.09090909091 2279 0.00213752476459164 154 1.34390466952651 1.47268793767101 1 5.9471591047157 3780 2279 4595 2765 638 154 3539 2618 2113 906 2145 2198 M11869 GO_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORT.html The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 311/954 Gene Ontology BP GO:0006812 0.0221936209462269 0.070627129577335 2280 1897.45454545455 2280 0.00203824767128016 339 1.28326792955272 1.41179624325143 1 5.60674272050103 2280 339 673 580 2299 3730 2419 3257 996 581 3718 2199 M16539 GO_UTERUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTERUS_DEVELOPMENT.html The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. 11/24 Gene Ontology BP GO:0060065 0.0647613500493312 0.146900707449814 3100 2323.90909090909 2280 0.00606819926165786 1091 1.46584243959724 1.46584243959724 1 4.63475807476509 3099 1122 1539 2280 1091 2672 2985 4454 2184 1824 2313 2200 M15826 GO_STEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 60/191 Gene Ontology BP GO:0016125 0.0735766029553369 0.158445571591463 2285 2115.18181818182 2281 0.00692354980563497 377 1.16090660385572 -1.00008319164076 -1 3.52581549252799 2281 377 1081 1735 1153 3899 2476 1930 2401 2511 3423 2201 M12585 GO_CEREBELLAR_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 34/95 Gene Ontology BP GO:0021695 0.170749046636152 0.271688767488572 2040 2216.54545454545 2282 0.0168770908919473 531 1.28836660323947 -1.27502197741866 -1 2.76763053941057 2036 3946 1240 2800 2995 531 2282 2972 3607 1031 942 2202 M15982 GO_CHROMATIN_SILENCING_AT_RDNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING_AT_RDNA.html Repression of transcription of ribosomal DNA by altering the structure of chromatin. 25/40 Gene Ontology BP GO:0000183 0.173371929815582 0.274047850792458 2005 2464.27272727273 2283 0.0171601866078131 1607 0.427504398098991 -0.496372704230716 -1 0.912259226953322 2004 2347 1607 3029 1624 1815 2960 1788 3256 4394 2283 2203 M13233 GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 35/75 Gene Ontology BP GO:0009142 0.245793860880136 0.358599868870961 740 2174.09090909091 2284 0.0253184775009721 687 0.253353069292157 -0.249661088157643 -1 0.428325311654649 739 2380 3438 3055 1929 687 1976 2284 2469 3679 1279 2204 M12808 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. 34/90 Gene Ontology BP GO:0010633 0.337011995971878 0.457528274063576 980 2051.27272727273 2285 0.0366740869714733 977 1.19045135446987 1.19045135446987 1 1.53448845841939 977 2808 2238 2356 2384 2285 1398 1469 2445 2605 1599 2205 M11325 GO_MATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING.html The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. 13/48 Gene Ontology BP GO:0007618 0.0396063306617517 0.104306405707608 3260 2405.27272727273 2286 0.00366707854354929 756 2.06322935667965 2.06322935667965 1 7.68827081995185 3259 3292 1428 1627 855 3598 4403 3021 756 1933 2286 2206 M13257 GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of receptor activity. 26/62 Gene Ontology BP GO:2000273 0.00832470211294935 0.0360219868689877 1140 1917.36363636364 2286 0.000759670027846834 79 1.02153487267164 -0.743128926420273 -1 5.59701999443997 1139 2162 2645 2670 2950 79 422 4014 2286 2469 255 2207 M14659 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. 10/28 Gene Ontology BP GO:2000679 0.148650840322485 0.250430279977249 2275 2452.63636363636 2286 0.0145237650352023 1242 0.32286413349146 -0.396880272856554 -1 0.736932555665689 2275 1242 3133 2286 1531 1542 2645 3921 2508 4067 1829 2208 M12260 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. 101/247 Gene Ontology BP GO:1900182 0.319803059550989 0.438395513875182 3925 2544.45454545455 2287 0.0344273176005897 1126 1.43645297618732 1.44579329203962 1 1.95273843770107 3923 2337 1997 2287 2037 2291 3904 1816 2244 1126 4027 2209 M12660 GO_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. 203/446 Gene Ontology BP GO:0097190 0.0738659056120715 0.158445571591463 1615 2268.18181818182 2287 0.00695174626381105 1155 1.42470460584059 1.5359311940741 1 4.32700232293595 1613 3371 2287 3017 1155 3733 2478 2084 1230 2410 1572 2210 M14696 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. 18/33 Gene Ontology BP GO:0034723 0.246844473065138 0.359842665130749 590 2308.81818181818 2287 0.0254419862045514 589 0.44824486896781 -0.61912783828511 -1 0.755257978663985 589 3096 1742 3020 2747 1654 2287 1294 2928 4074 1966 2211 M15163 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION.html The process in which immune receptor genes are diversified through somatic mutation. 6/14 Gene Ontology BP GO:0002566 0.25223601049052 0.36609309056189 1220 2235.09090909091 2288 0.0286484116343488 743 0.277604928869562 -0.277604928869562 -1 0.459862051371703 1217 2325 4364 2943 2288 743 1082 1368 3083 4197 976 2212 M15799 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. 18/33 Gene Ontology BP GO:0006335 0.247507650546666 0.360694342320622 590 2335.45454545455 2288 0.0255200292127345 590 0.44824486896781 -0.61912783828511 -1 0.753511127950528 590 3097 1743 3021 2748 1655 2288 1295 2929 4357 1967 2213 M11823 GO_NAD_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 32/75 Gene Ontology BP GO:0019674 0.0770450762137896 0.158445571591463 2885 2251.27272727273 2290 0.0072621280483402 311 1.19066997486459 1.19066997486459 1 3.61621049439087 2883 1101 2290 2328 4231 311 1649 3868 2960 1744 1399 2214 M13284 GO_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions within an organism or cell. 28/98 Gene Ontology BP GO:0055081 0.00247343532617272 0.0152108082376423 2290 2110.72727272727 2290 0.000225110960612464 157 1.10751365860546 -0.948238765283616 -1 7.6421194062403 2290 2454 653 1819 157 4129 3308 1371 2661 1547 2829 2215 M16753 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. 9/16 Gene Ontology BP GO:2000727 0.1109531486613 0.198595015125065 3815 2601.81818181818 2290 0.0116916495895783 1188 1.0923235667937 1.0923235667937 1 2.91081920027285 3812 1188 4616 1802 1416 1847 2290 2808 3205 1636 4000 2216 M10572 GO_PROTEIN_HOMOTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTETRAMERIZATION.html The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. 42/87 Gene Ontology BP GO:0051289 0.232850105696956 0.342669743502683 2305 2260.27272727273 2291 0.0238095238095238 949 0.407868454474931 -0.399375377550001 -1 0.720105821859609 2303 1155 2291 2650 2051 949 2448 4381 1908 3052 1675 2217 M13054 GO_REGULATION_OF_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_LOCALIZATION.html Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. 734/1866 Gene Ontology BP GO:0060341 0.100646580329257 0.183255714693623 2685 2564.54545454545 2291 0.0105518540853611 1364 1.23369886281573 1.36279144778329 1 3.45103992026808 2682 2237 4000 2348 1364 1467 3247 2193 2291 1851 4530 2218 M13302 GO_ONE_CARBON_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_METABOLIC_PROCESS.html The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. 20/37 Gene Ontology BP GO:0006730 0.0839184282471183 0.158445571591463 2635 2279 2291 0.00793650793650794 726 0.944678121109151 0.989282451677066 1 2.86910311626977 2635 726 1070 1420 4284 4329 1732 2401 776 2291 3405 2219 M13388 GO_AMINO_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_METABOLIC_PROCESS.html The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. 20/46 Gene Ontology BP GO:0006040 0.0839184282471183 0.158445571591463 1280 2434.81818181818 2292 0.00793650793650794 330 3.21934379747048 3.21934379747048 1 9.77754127641277 1966 2781 1276 1849 4108 3789 4132 1277 330 2292 2983 2220 M14541 GO_POSITIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WOUND_HEALING.html Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 25/85 Gene Ontology BP GO:0090303 0.0774460332690565 0.158445571591463 2835 2520.18181818182 2292 0.00730134240078155 855 0.471355685420894 -0.472218766552634 -1 1.43156492736488 2835 1531 855 1907 1821 1498 3086 4011 3845 4041 2292 2221 M10429 GO_SINGLE_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BEHAVIOR.html The specific behavior of a single organism in response to external or internal stimuli. 185/632 Gene Ontology BP GO:0044708 0.0839184282471183 0.158445571591463 2295 2400.54545454545 2293 0.00793650793650794 613 1.47243992938705 1.57432306005336 1 4.47198034507005 2293 3034 1094 1964 1790 4609 3380 2975 984 613 3670 2222 M10515 GO_NEURON_PROJECTION_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION.html Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 29/84 Gene Ontology BP GO:1990138 0.201270219006499 0.30861876712258 1915 2168.36363636364 2293 0.0202229519351203 1097 1.75580034896695 1.75580034896695 1 3.40286074978349 1913 2293 1097 2440 2750 2636 2141 1707 2426 1560 2889 2223 M12798 GO_MAINTENANCE_OF_LOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION.html Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. 83/197 Gene Ontology BP GO:0051235 0.35943518917414 0.479556776820555 1830 2767.63636363636 2293 0.0396825396825397 1636 1.2090051750896 -0.819838460814685 -1 1.46468354650353 4066 3085 1779 1828 2293 1636 4103 3684 2216 1826 3928 2224 M10609 GO_SODIUM_ION_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_EXPORT.html The directed movement of sodium ions out of a cell or organelle. 4/15 Gene Ontology BP GO:0071436 0.0956179249911956 0.176032524081729 2310 2040 2294 0.01 164 1.38933387508025 1.38933387508025 1 3.97850230190943 2307 164 3611 296 3331 2294 2667 3908 1638 1087 1137 2225 M11839 GO_AMEBOIDAL_TYPE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMEBOIDAL_TYPE_CELL_MIGRATION.html Cell migration that is accomplished by extension and retraction of a pseudopodium. 90/270 Gene Ontology BP GO:0001667 8.71666503284089e-05 0.00129286174050928 1945 2180.54545454545 2297 7.92455492433536e-06 252 1.30995030758415 1.30995030758415 1 14.3623859537183 1942 1721 252 1264 2355 4369 2510 3552 2297 684 3040 2226 M13798 GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION.html The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. 50/170 Gene Ontology BP GO:0099531 0.0147895679296757 0.0536468467949094 2030 2036.63636363636 2299 0.00135363065147363 113 1.4227640217421 -1.4227640217421 -1 6.86119346903183 2030 3314 2322 3482 1808 113 1220 2299 3121 2342 352 2227 M15433 GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification. 22/71 Gene Ontology BP GO:1903309 0.348456311799275 0.471548427771505 2420 2565.72727272727 2301 0.0381977769518096 1703 1.13115893914357 -1.13115893914357 -1 1.40177742829792 2417 2020 3056 2301 2095 1703 4192 3821 2245 2367 2006 2228 M13939 GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. 6/18 Gene Ontology BP GO:0032645 0.0427663968657939 0.109788539353224 1915 2457.90909090909 2302 0.00436124382523191 641 0.57445197773371 0.70985830500009 1 2.09208890073076 1914 2516 4160 2302 4542 1664 641 671 2917 3882 1828 2229 M16215 GO_DNA_PACKAGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING.html Any process in which DNA and associated proteins are formed into a compact, orderly structure. 102/328 Gene Ontology BP GO:0006323 0.0417753021341345 0.108177762302725 220 2072.54545454545 2302 0.00387184677821725 220 1.2451718004747 -1.2451718004747 -1 4.56511361354984 220 3269 1014 3309 2604 1233 2302 1511 3218 2599 1519 2230 M11225 GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. 202/480 Gene Ontology BP GO:1903651 0.0844200090940495 0.159010994816905 3520 2476.54545454545 2303 0.00798590051405036 1226 1.2061778068133 1.31624854925149 1 3.65622659037419 3517 2697 1567 2198 1226 1484 4333 2303 2669 1243 4005 2231 M15386 GO_CEREBELLAR_CORTEX_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_FORMATION.html The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 17/45 Gene Ontology BP GO:0021697 0.161385165508919 0.258740097879113 2960 2067.27272727273 2303 0.0158730158730159 534 1.28836660323947 -1.27502197741866 -1 2.87134642708929 2960 2303 1456 1789 3068 2527 2743 2636 1483 534 1241 2232 M14996 GO_DEVELOPMENTAL_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_CELL_GROWTH.html The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. 49/120 Gene Ontology BP GO:0048588 0.204498596060537 0.312742747532633 2405 2293.45454545455 2304 0.0205836287025723 1486 1.56263005506788 1.56263005506788 1 2.99428904814231 2402 2200 1523 2304 1733 3671 2449 1978 2436 1486 3046 2233 M15287 GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 13/42 Gene Ontology BP GO:0071392 0.0103933429216339 0.0417015156251411 2305 2090.36363636364 2304 0.000949342805708048 392 1.56143222277456 1.56143222277456 1 8.17827420189372 2304 3684 910 2960 392 2751 1521 2866 2736 884 1986 2234 M14679 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of production of a cytokine. 206/572 Gene Ontology BP GO:0001819 0.0616352163338049 0.141877400573996 1185 2038.63636363636 2305 0.00576662793041158 818 1.26833930598795 1.31565304310027 1 4.08303379483726 1183 2331 818 2678 2076 2801 1601 1620 2305 2432 2580 2235 M16267 GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 130/307 Gene Ontology BP GO:0040029 0.200315406080148 0.307764536872973 1115 2223.27272727273 2305 0.0201165334379858 651 1.01341452690149 -1.03463152579236 -1 1.96869698104557 1113 4119 2352 4327 1812 651 2305 1199 2712 2906 960 2236 M11645 GO_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 20/62 Gene Ontology BP GO:0043330 0.232850105696956 0.342669743502683 1885 2486.63636363636 2306 0.0238095238095238 1797 1.22669328210816 1.22669328210816 1 2.16576929285746 1881 4037 2482 2998 1908 3451 2306 1871 1797 2283 2339 2237 M12501 GO_METALLO_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLO_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. 14/22 Gene Ontology BP GO:0031163 0.354089145729232 0.478334566081124 2840 2472.90909090909 2306 0.0389566851006443 960 0.686007751272719 -0.686007751272719 -1 0.833969406983095 2837 2306 3273 2821 2106 960 1690 2279 3682 3504 1744 2238 M16507 GO_PROTEIN_AUTOPROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPROCESSING.html Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. 10/19 Gene Ontology BP GO:0016540 0.00279558286383342 0.01657712801632 990 1945.72727272727 2306 0.000254467418006534 150 0.41029811840831 -0.448032008423319 -1 2.77297828127887 986 2792 2306 3158 3445 376 335 165 3171 4519 150 2239 M11117 GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. 10/18 Gene Ontology BP GO:0045820 0.0228665569446698 0.0721749992481999 3555 2389.54545454545 2307 0.00210070422293365 622 0.495019055413657 -0.612170353255099 -1 2.14510292177678 3553 2222 1962 2307 622 2059 2365 3886 1821 3171 2317 2240 M16025 GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. 20/37 Gene Ontology BP GO:0044803 0.00753048779910352 0.0333945127518984 1040 2324 2307 0.000686944407225727 135 1.45023161899474 1.45023161899474 1 8.12693043302527 1036 4504 2775 4099 4348 608 135 1513 3848 2307 391 2241 M14564 GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 10/18 Gene Ontology BP GO:0051198 0.0228665569446698 0.0721749992481999 3555 2468.36363636364 2308 0.00210070422293365 623 0.495019055413657 -0.612170353255099 -1 2.14510292177678 3554 2223 1963 2308 623 2060 2366 3869 1822 4046 2318 2242 M15248 GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 10/18 Gene Ontology BP GO:0051195 0.0228665569446698 0.0721749992481999 3555 2486.09090909091 2309 0.00210070422293365 624 0.495019055413657 -0.612170353255099 -1 2.14510292177678 3555 2224 1964 2309 624 2061 2367 3881 1823 4220 2319 2243 M16557 GO_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PROCESS.html The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 20/73 Gene Ontology BP GO:0050886 0.161385165508919 0.258740097879113 3835 2765.27272727273 2309 0.0158730158730159 724 1.07272638267715 -1.07272638267715 -1 2.39075513007053 3832 724 1522 1135 2104 4301 4244 4128 1495 2309 4624 2244 M15283 GO_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING.html Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. 52/107 Gene Ontology BP GO:0006342 0.417667157414569 0.537291837823722 1010 2251.45454545455 2312 0.0479671480028049 1009 1.0878044685602 -1.0878044685602 -1 1.11399573034843 1009 2959 1928 2817 2993 1482 2312 1585 3042 2760 1879 2245 M15529 GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 20/44 Gene Ontology BP GO:0002089 0.0428417751315686 0.109897437533632 1920 2335.27272727273 2312 0.00397268492139216 896 1.31394404283802 1.31394404283802 1 4.78308764860107 1917 3428 2330 3152 896 2442 1676 3647 1583 2305 2312 2246 M15157 GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that activates or increases the frequency, rate, or extent of peptide secretion. 47/128 Gene Ontology BP GO:0002793 0.0367349020740013 0.0986203392393756 1595 2304.81818181818 2313 0.00339663847812528 598 1.50707418051067 -0.816391131298516 -1 5.75511897952792 1594 3172 1401 2602 3184 3533 2313 598 2284 2728 1944 2247 M10178 GO_ETHER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHER_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. 5/13 Gene Ontology BP GO:0018904 0.0333317946546865 0.0930291037311123 820 2355.90909090909 2314 0.00338425644513627 816 0.254006497371755 -0.38695883675202 -1 0.994423209706991 1852 2947 3550 3210 816 818 2060 2314 4137 2968 1243 2248 M15401 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 4/13 Gene Ontology BP GO:0034374 0.147859119791321 0.249186894080256 3855 2530.72727272727 2315 0.0158730158730159 584 0.813684489263087 -1.02325812779008 -1 1.86389914914554 3851 584 4397 1072 1662 2315 2055 3449 1271 4260 2922 2249 M16329 GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 191/682 Gene Ontology BP GO:0098660 0.0839184282471183 0.158445571591463 2275 2219.72727272727 2315 0.00793650793650794 494 1.38019890973444 1.51635748249811 1 4.19183307476086 2274 1824 899 2622 2315 3947 2697 2739 1005 494 3601 2250 M10802 GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM.html The growth process in which a branch increases in length from its base to its tip. 10/23 Gene Ontology BP GO:0060602 0.14627029180186 0.248766653786094 3600 2592.63636363636 2317 0.01427357417679 1523 1.46584243959724 1.46584243959724 1 3.3618696887431 3597 2317 1887 1940 1523 3294 3810 3346 1668 1676 3461 2251 M11270 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. 23/62 Gene Ontology BP GO:0086004 0.359148219670103 0.479556776820555 2320 2205.27272727273 2318 0.0396434370146707 901 1.26454268131947 -1.13975148755868 -1 1.53196603071004 2318 2707 1650 2608 3695 901 2207 2396 2530 1292 1954 2252 M13274 GO_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. 8/19 Gene Ontology BP GO:0046931 0.393345879295049 0.514803961150029 1795 2722.18181818182 2318 0.0487512147347732 1003 0.229661200801228 -0.251723547080688 -1 0.25137787320213 1792 3645 4042 3439 2318 1003 1920 2272 4165 3692 1656 2253 M11577 GO_VENTRICULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. 21/67 Gene Ontology BP GO:0021591 0.0744454084717815 0.158445571591463 3355 2660.18181818182 2319 0.00700825075014325 305 1.1712352121029 1.1712352121029 1 3.55718474036845 3352 4013 1649 3705 4562 305 1983 1965 4311 2319 1098 2254 M13758 GO_IRON_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. 14/22 Gene Ontology BP GO:0016226 0.354089145729232 0.478334566081124 2840 2506.90909090909 2319 0.0389566851006443 961 0.686007751272719 -0.686007751272719 -1 0.833969406983095 2838 2307 3274 2822 2107 961 1691 2319 3683 3829 1745 2255 M12133 GO_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of vacuolar transport. 21/40 Gene Ontology BP GO:1903335 0.35943518917414 0.479556776820555 3410 2528.72727272727 2320 0.0396825396825397 1435 1.69748649654937 1.69748649654937 1 2.05646807244638 3408 1435 1714 1876 3701 1859 3784 2968 2186 2320 2565 2256 M13623 GO_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that modulates the frequency, rate or extent of reproductive process. 67/184 Gene Ontology BP GO:2000241 0.155007524437311 0.258698754839122 2595 2385.27272727273 2321 0.0151949695475798 1378 1.25053204594924 1.18121393020292 1 2.78735504035782 2592 2199 1753 2321 1557 3462 1378 3148 1629 2581 3618 2257 M14167 GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 8/18 Gene Ontology BP GO:0060391 0.000510446855852002 0.00496856342079842 3740 2285.81818181818 2321 5.10564143967723e-05 65 1.19859715498945 -1.38975139692581 -1 10.4814033544029 3737 664 4196 547 65 3236 3036 2210 2321 623 4509 2258 M11163 GO_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of muscle contraction. 89/232 Gene Ontology BP GO:0006937 0.00283111869544243 0.0166813250037299 2275 2390.90909090909 2322 0.000257706232779002 455 1.51066136972376 1.35464538636068 1 10.1941212554912 2272 2660 455 2339 2257 4457 2322 4231 1459 457 3391 2259 M12553 GO_EPITHELIAL_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. 21/60 Gene Ontology BP GO:0003351 0.184568347179233 0.28853563500107 2080 2313 2323 0.0183779074286248 560 1.29644110978073 1.29644110978073 1 2.65639920570392 2076 3778 2869 3298 1824 560 1573 3354 2953 2323 835 2260 M16565 GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of establishment of protein localization. 348/851 Gene Ontology BP GO:1904951 0.051133850155118 0.1246965528694 3050 2325.45454545455 2323 0.00476022800210983 938 1.26366719166349 1.39439365197431 1 4.33688884555994 3050 2192 938 2323 977 1765 3668 2532 2559 1171 4405 2261 M10423 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN.html The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. 6/27 Gene Ontology BP GO:0001991 0.0450584324668373 0.114195579663497 860 2006.18181818182 2324 0.00459990052227248 354 0.390286448756668 0.443615862258171 1 1.39605736415628 858 2324 3582 2656 3854 780 354 1875 2336 3023 426 2262 M13934 GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 104/244 Gene Ontology BP GO:0046824 0.298735036746822 0.413174493778819 3660 2544.09090909091 2326 0.0317460317460317 860 1.43842135373123 1.4465330131988 1 2.09591449637323 3656 2731 1379 2326 2266 2593 4034 1516 2086 860 4538 2263 M16271 GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 11/27 Gene Ontology BP GO:0042454 0.46544537564037 0.580826820010117 2050 2861.18181818182 2328 0.05534765224382 1183 1.0296882537552 -1.0296882537552 -1 0.922229723073117 2050 4179 2253 4241 3889 1183 2328 3911 4268 1821 1350 2264 M14207 GO_GOLGI_TO_VACUOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_VACUOLE_TRANSPORT.html The directed movement of substances from the Golgi to the vacuole. 21/38 Gene Ontology BP GO:0006896 0.00826359926589351 0.0357909434622608 3775 2309.63636363636 2329 0.000754073005291946 339 1.31962195245356 1.31962195245356 1 7.24424590307603 3774 1166 2920 1694 339 1763 3059 4125 1378 2329 2859 2265 M15680 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 56/201 Gene Ontology BP GO:0070588 0.0817905494726908 0.158445571591463 1435 2199.09090909091 2329 0.00772724061454762 865 1.40067451730165 1.50748703129138 1 4.25402000189456 1433 3418 865 3165 1789 3760 2680 2616 1052 1083 2329 2266 M13839 GO_SIGNAL_RELEASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_RELEASE.html The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. 81/246 Gene Ontology BP GO:0023061 0.102701481109279 0.186558285129257 3185 2220 2330 0.00980314871445549 602 1.41341452667306 -1.30608480872045 -1 3.91214354158365 3184 2446 1239 3121 1320 602 2330 3905 2770 1754 1749 2267 M14277 GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 27/56 Gene Ontology BP GO:0051353 0.221097764476246 0.332111588632549 3305 2542.27272727273 2330 0.0224593780422529 1587 1.03069309216194 -1.03069309216194 -1 1.87289966587996 3303 1731 1715 1587 1780 3980 2465 2273 2330 2497 4304 2268 M10099 GO_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMORY.html The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). 43/156 Gene Ontology BP GO:0007613 0.161385165508919 0.258740097879113 2335 2319.81818181818 2331 0.0158730158730159 811 1.57842243985917 1.69027250586902 1 3.51778571548094 2331 1841 1783 1794 2964 3525 2614 3293 1356 811 3206 2269 M11866 GO_AMINO_ACID_BETAINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_TRANSPORT.html The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/40 Gene Ontology BP GO:0015838 0.43400067088561 0.552981645148707 2320 2739.90909090909 2335 0.0553268068065742 1452 0.419693190748656 0.373763901300084 1 0.409883892650533 2335 2229 3818 2318 2316 3386 3118 2061 3748 3358 1452 2270 M15515 GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 21/58 Gene Ontology BP GO:0071470 0.00551993646445615 0.0268648480130712 2655 1955.90909090909 2335 0.000503075924893429 270 0.947881442117767 0.976907458631932 1 5.65179577828004 2654 536 1281 942 270 3763 2793 2680 1218 2335 3043 2271 M16118 GO_IMMUNOLOGICAL_SYNAPSE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE_FORMATION.html The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 21/51 Gene Ontology BP GO:0001771 0.0686282531019965 0.153192778438735 2135 2503 2336 0.0064425014218763 1116 1.31394404283802 1.31394404283802 1 4.06363517278561 2132 4064 1877 3761 1116 3029 2070 2876 1457 2336 2815 2272 M13312 GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 93/217 Gene Ontology BP GO:0010771 0.0205779856833405 0.0671960161320068 2340 2043 2337 0.00188845667363883 438 1.40825346551435 1.40825346551435 1 6.2684312261761 2337 1144 660 438 2396 4039 3920 2629 794 489 3627 2273 M16182 GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-alpha production. 21/57 Gene Ontology BP GO:0032647 0.35943518917414 0.479556776820555 3480 2619.27272727273 2337 0.0396825396825397 1004 1.29644110978073 1.29644110978073 1 1.57061028492401 3479 1851 2894 2322 3857 1004 2573 4399 2295 2337 1801 2274 M16700 GO_RESPONSE_TO_MONOAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MONOAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. 16/70 Gene Ontology BP GO:0071867 0.0199268924735179 0.0658568552552914 2195 2531 2337 0.00182815511980335 442 0.858982002181133 0.858982002181133 1 3.85201436881861 2194 2169 1926 2711 2337 2729 2679 442 4030 4570 2054 2275 M10636 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. 36/89 Gene Ontology BP GO:0032757 0.208379755044787 0.317111505300867 3330 2352.72727272727 2338 0.021019000415311 622 1.38114177468899 1.38114177468899 1 2.61493856238093 3329 622 1107 1343 2338 3765 2415 2896 2009 1910 4146 2276 M11784 GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 80/213 Gene Ontology BP GO:0032869 0.172754362263368 0.273753755627584 2445 2352.36363636364 2338 0.0170934572507353 807 1.3634246385958 1.50071469381724 1 2.91184938237821 2443 2338 1463 1291 1617 4424 3065 2864 1758 807 3806 2277 M16460 GO_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERAD_PATHWAY.html Any process that modulates the frequency, rate or extent of ERAD pathway. 19/37 Gene Ontology BP GO:1904292 0.0353956136281955 0.0962188724096672 2340 2430.63636363636 2338 0.00327075067663765 391 0.522536967759313 0.522536967759313 1 2.01666633767223 2338 3629 3127 3481 801 391 1965 1800 4194 4508 503 2278 M10203 GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT.html The directed movement of substances from endoplasmic reticulum to cytosol. 12/32 Gene Ontology BP GO:1903513 0.0485363697079897 0.119828721561994 2340 2445.36363636364 2339 0.00451286053435454 755 0.522536967759313 0.522536967759313 1 1.82764093451834 2339 2931 2877 3876 956 755 2155 2079 4270 2976 1685 2279 M13246 GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 72/165 Gene Ontology BP GO:0072522 0.0187809581545809 0.0633720848195633 2050 2327.45454545455 2339 0.001722111833074 569 0.648828184364399 0.648828184364399 1 2.9507385661361 2046 2339 3132 2994 569 763 2134 2372 3734 3684 1835 2280 M16636 GO_ESTROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 10/50 Gene Ontology BP GO:0008210 0.0190811661001496 0.0640129004356896 1580 2311.81818181818 2339 0.00174988180151268 217 0.50491279453589 -0.50491279453589 -1 2.28786620297547 1578 2029 2632 2170 2339 2666 217 3521 2368 4551 1359 2281 M12932 GO_TISSUE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MIGRATION.html The process in which the population of cells that make up a tissue undergo directed movement. 62/181 Gene Ontology BP GO:0090130 0.000292073225284862 0.00321349759478108 3415 2668.27272727273 2340 2.65556371179553e-05 307 1.32950558757906 1.32950558757906 1 12.5812418994531 3413 2340 307 2022 1325 3694 4513 4033 2108 1245 4351 2282 M13291 GO_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 22/76 Gene Ontology BP GO:0042446 0.167692245544553 0.267282902871047 2320 2395.18181818182 2341 0.0165481864472759 1598 1.38916827744188 -1.38916827744188 -1 3.0216110070877 2316 2634 2341 2372 1598 2147 1887 3366 1781 2358 3547 2283 M15292 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that modulates the frequency, rate or extent of protein localization to nucleus. 158/363 Gene Ontology BP GO:1900180 0.222966504068044 0.33448577653891 2655 2298.18181818182 2341 0.0226728211067911 987 1.30645422210802 1.37873979637757 1 2.35865096147138 2653 1880 2091 1996 2413 3620 2341 1250 2395 987 3654 2284 M14099 GO_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. 526/1416 Gene Ontology BP GO:0006629 0.0699400898982766 0.155448462133891 3940 2597.81818181818 2342 0.00722440515917575 590 1.18848621179228 -0.932323045393199 -1 3.64699336924481 3937 590 4185 981 1181 2342 4141 4613 1526 1436 3644 2285 M10048 GO_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. 49/162 Gene Ontology BP GO:0021510 0.0402112137521508 0.105409453611626 3005 2379.09090909091 2343 0.00372414203166103 602 1.55555285917543 1.56715922322288 1 5.76952556075938 3003 2343 748 1860 2395 2799 4241 2098 2211 602 3870 2286 M13817 GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. 7/19 Gene Ontology BP GO:1900745 0.44906203323788 0.56827337703011 2170 2811.09090909091 2343 0.0578712212224105 1416 1.35593454827845 1.35593454827845 1 1.26326964003609 2166 1747 4137 2305 2343 4449 4547 2771 2727 1416 2314 2287 M15585 GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 18/49 Gene Ontology BP GO:0032350 0.231444440343845 0.342669743502683 3900 2215.27272727273 2343 0.0236470504537661 408 1.38925107626107 -1.38916827744188 -1 2.45277068436645 3900 408 1136 948 2603 4100 3574 2590 1694 1072 2343 2288 M15756 GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. 25/50 Gene Ontology BP GO:1904837 0.0660890099407543 0.148812450608595 3235 2155.72727272727 2343 0.00619655304967264 1100 1.10858603309022 1.10858603309022 1 3.48154119334904 3235 1528 2009 1979 1100 1124 2482 2953 2343 2444 2516 2289 M15906 GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 12/38 Gene Ontology BP GO:0046473 0.35943518917414 0.479556776820555 2985 2547.18181818182 2344 0.0396825396825397 1551 1.27675999939789 -1.27675999939789 -1 1.54676704657227 2982 3185 2561 2901 2275 1551 4036 2344 2234 1890 2060 2290 M11255 GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 51/124 Gene Ontology BP GO:0051341 0.203717833077784 0.311754086677703 3185 2603.27272727273 2345 0.0204962794352281 1693 1.12262262161733 -1.03069309216194 -1 2.15701285070104 3181 2157 1693 2508 1729 4307 1881 2214 2378 2345 4243 2291 M11655 GO_UV_PROTECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_UV_PROTECTION.html Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. 8/13 Gene Ontology BP GO:0009650 0.0646294932173796 0.146900707449814 2720 2435 2346 0.00665898645568415 788 1.29733809947519 1.29733809947519 1 4.10197444813053 2716 3549 3784 2220 1307 4016 2346 788 1716 1504 2839 2292 M15859 GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). 8/19 Gene Ontology BP GO:0048016 0.283461912920644 0.401744096975137 1835 2584.36363636364 2347 0.0327829847893146 1409 0.485247597314524 0.642574727503688 1 0.729493095883556 1835 1614 4468 2347 2038 2106 2890 1409 2815 4365 2541 2293 M15284 GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS.html Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. 8/15 Gene Ontology BP GO:0051457 0.139222201469375 0.239321984976789 1395 2190.63636363636 2349 0.0148800692918282 730 0.671837249370926 -0.671837249370926 -1 1.58370789402571 1395 3027 4380 2594 2776 746 730 1063 2349 4228 809 2294 M10283 GO_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. 168/410 Gene Ontology BP GO:0006644 0.0336228003059213 0.0932003951166524 3825 2544.90909090909 2350 0.0031043574062494 782 1.42566837067144 1.76938901965378 1 5.57709962442725 3823 1825 1977 1236 782 3327 3736 3917 865 2350 4156 2295 M12872 GO_PROTEIN_O_LINKED_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_FUCOSYLATION.html The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. 6/19 Gene Ontology BP GO:0036066 0.450920719051006 0.570159286098536 1300 2588.63636363636 2351 0.0581895484510631 1298 0.311743660251652 0.430596742562622 1 0.288736340192303 1298 3670 3973 3464 2351 1424 1605 2107 3252 3591 1740 2296 M10913 GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. 8/16 Gene Ontology BP GO:0033240 0.1999444587336 0.307296299867629 2955 2595.54545454545 2352 0.0220604422161257 745 0.494975575253624 -0.586528324108638 -1 0.962800449941366 2952 745 3658 2260 1767 2007 4074 3768 1850 3118 2352 2297 M11544 GO_PROTEIN_LOCALIZATION_TO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CENTROSOME.html A process in which a protein is transported to, or maintained at, the centrosome. 10/22 Gene Ontology BP GO:0071539 0.158023477037598 0.258740097879113 3255 2329.09090909091 2352 0.0155150320961182 723 0.493393016758395 -0.493393016758395 -1 1.09961114493127 1745 3255 3253 2497 2352 909 1501 2187 3913 3285 723 2298 M10533 GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 21/84 Gene Ontology BP GO:0090207 0.142442765166889 0.243595491222787 2355 2303.81818181818 2353 0.0138726353386847 1182 1.51400851384581 1.51400851384581 1 3.52476600018663 2353 2743 1182 2118 1504 3264 3363 2195 2875 1224 2521 2299 M13126 GO_NEURON_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. 7/44 Gene Ontology BP GO:0048665 0.263252693887049 0.379119806984358 1520 2471.63636363636 2353 0.0300890650909294 859 0.367893160877987 0.385414935657321 1 0.588222407003472 1519 1992 4017 2925 2381 2353 859 2048 3630 3654 1810 2300 M14285 GO_REGULATION_OF_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACROSOME_REACTION.html Any process that modulates the frequency, rate or extent of the acrosome reaction. 3/28 Gene Ontology BP GO:0060046 0.141005490562139 0.241671647353272 4035 2940.72727272727 2354 0.0150843489046389 1552 0.523786086858617 0.232764358402506 1 1.22627382020784 4032 2329 4218 2294 1552 2183 3700 2354 2152 3968 3566 2301 M16418 GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 13/30 Gene Ontology BP GO:0051984 0.151133280205555 0.253309625317896 3065 2231.45454545455 2354 0.0147853427867343 887 1.53222578464289 -1.33403223803043 -1 3.46840647667011 3061 2354 1639 1251 1543 4114 2576 2404 2170 887 2547 2302 M12069 GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 69/221 Gene Ontology BP GO:0002263 0.0738188480742905 0.158445571591463 1605 2635.81818181818 2355 0.00694715932481953 802 0.96884206496509 0.953379308165877 1 2.9424919722976 1603 4160 2355 3983 4614 2271 1377 802 2892 2601 2336 2303 M12440 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD.html The morphogenetic process in which an epithelial sheet bends along a linear axis. 11/25 Gene Ontology BP GO:0060571 0.63389956273523 0.731410454716618 2020 2511.36363636364 2358 0.0873015873015873 1746 1.21455215107271 1.21455215107271 1 0.626249439981355 2019 2358 1746 2197 4080 2789 1826 3182 2951 1789 2688 2304 M14090 GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. 4/18 Gene Ontology BP GO:0070296 0.190760242263156 0.296915791092133 1200 2254.09090909091 2358 0.0209435764726226 794 0.798313306305126 -0.798313306305126 -1 1.59806082782374 1198 2725 4183 3163 2358 855 794 1213 3304 3920 1082 2305 M12259 GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. 17/55 Gene Ontology BP GO:0043534 0.155843654854707 0.258740097879113 3635 2366.90909090909 2359 0.0152835982048287 1026 1.20313380481586 1.20313380481586 1 2.68139048549303 1512 3633 1026 3200 3000 3002 2334 2359 3635 1038 1297 2306 M13667 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. 22/49 Gene Ontology BP GO:0061418 0.161385165508919 0.258740097879113 2505 2605.63636363636 2359 0.0158730158730159 1376 1.42010235024591 1.42010235024591 1 3.16494218279973 2502 2298 2220 1535 4010 3871 2884 2046 1376 2359 3561 2307 M15395 GO_KETONE_BODY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BODY_METABOLIC_PROCESS.html The chemical reactions and pathways involving ketone body. 5/14 Gene Ontology BP GO:1902224 0.000150418003233493 0.00196729799722002 3010 2022 2359 1.50428185712601e-05 22 0.816391131298516 -0.816391131298516 -1 8.38598615560006 3010 1061 4396 327 33 2359 2989 1155 22 4257 2633 2308 M13762 GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. 13/45 Gene Ontology BP GO:0031664 0.0315011861479581 0.0892373442861315 1640 2381.45454545455 2360 0.00290559065526337 558 1.48034281358945 1.48034281358945 1 5.89702099954425 1636 3919 2792 2644 2865 2259 3006 558 2360 1947 2210 2309 M12974 GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 16/43 Gene Ontology BP GO:0071377 0.542474400561249 0.654720208423676 2230 2488.72727272727 2362 0.0686162153636826 1034 1.46693471565438 1.46693471565438 1 1.02424592222529 2227 1034 1455 1853 3330 3618 3001 2362 3353 2112 3031 2310 M13489 GO_LIPID_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSLOCATION.html The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. 10/30 Gene Ontology BP GO:0034204 0.298735036746822 0.413174493778819 2365 2378.63636363636 2362 0.0317460317460317 1324 1.30774781221536 1.30774781221536 1 1.90551092007187 2362 2937 1674 1324 3775 3016 2593 1629 1949 1698 3208 2311 M11780 GO_DORSAL_VENTRAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_PATTERN_FORMATION.html The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 38/135 Gene Ontology BP GO:0009953 0.194187384763645 0.301340918267916 2735 2809.81818181818 2363 0.019436272916731 1372 1.20206290490189 1.10821865888993 1 2.3769700511563 2733 1372 2363 2192 1697 4442 3738 3833 2351 1990 4197 2312 M13770 GO_OXIDATION_REDUCTION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATION_REDUCTION_PROCESS.html A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. 435/1065 Gene Ontology BP GO:0055114 0.0403790273103665 0.105741581388625 3105 2121.27272727273 2363 0.00373997902790453 357 1.19182077217294 1.36883185285912 1 4.41426712317598 3103 915 2572 2363 864 357 3209 4124 1900 2761 1166 2313 M15398 GO_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_GROWTH.html The increase in size or mass of the heart. 20/43 Gene Ontology BP GO:0060419 0.0262906013832207 0.0793159598585406 2670 2573 2365 0.00241910365644607 501 1.08918898596586 1.08918898596586 1 4.55046243628816 2668 1540 2365 2213 4372 4011 2870 501 2025 2304 3434 2314 M14846 GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. 11/22 Gene Ontology BP GO:0032682 0.0554471895673835 0.132223321634138 2725 2435.27272727273 2366 0.00517236609636924 655 0.540526206155408 0.645827228008332 1 1.80285428659844 2721 655 1754 1870 1009 4261 2810 2334 2366 4111 2897 2315 M15690 GO_REGULATION_OF_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H4_ACETYLATION.html Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. 10/16 Gene Ontology BP GO:0090239 0.0860712868777033 0.161075769840055 2240 2457.81818181818 2367 0.00814868210794275 458 0.330520411672957 0.402662664983418 1 0.99486042472317 2236 2648 2367 3004 3111 1869 458 1227 3804 4330 1982 2316 M12571 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. 11/32 Gene Ontology BP GO:0006359 0.402121784186853 0.523570231065496 1810 2922.72727272727 2368 0.0456843052023887 1561 1.21455215107271 1.21455215107271 1 1.29559254094394 1807 4625 2793 4508 4494 2283 1919 1561 4002 1790 2368 2317 M16868 GO_CELLULAR_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 22/52 Gene Ontology BP GO:0071312 0.1300171781483 0.225924310682095 1120 2643.18181818182 2370 0.0125821573228944 550 0.821809750370218 -0.989745402399581 -1 2.01528250793663 1119 3981 2370 3499 4188 2067 550 1774 3206 4614 1707 2318 M12925 GO_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. 407/922 Gene Ontology BP GO:0043603 0.0360432147184037 0.0971534283090433 2550 2126.18181818182 2371 0.00333160275623836 641 1.45275600889813 1.62999572784801 1 5.58358204803287 2547 2371 3481 2068 810 641 3576 2908 961 2407 1618 2319 M11899 GO_ADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. 24/64 Gene Ontology BP GO:0046031 0.232850105696956 0.342669743502683 4105 2677.63636363636 2372 0.0238095238095238 953 1.50049685841841 1.50049685841841 1 2.64917894916261 4103 953 2024 1805 2812 2372 4071 3663 1766 1351 4534 2320 M12759 GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of female gonad development. 3/17 Gene Ontology BP GO:2000194 0.259133522427534 0.374465279997211 2020 2627.09090909091 2373 0.0295481451556474 1090 0.435095940569498 0.561652568823172 1 0.704533013237897 2016 2367 3956 2373 1938 2149 1090 3146 3495 3571 2797 2321 M13281 GO_4_HYDROXYPROLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_HYDROXYPROLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. 12/15 Gene Ontology BP GO:0019471 0.0839184282471183 0.158445571591463 3380 2415.09090909091 2373 0.00793650793650794 554 1.8636644772713 1.8636644772713 1 5.66017719697476 3380 3252 2373 2002 2226 3557 3121 1055 554 1876 3170 2322 M13394 GO_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/158 Gene Ontology BP GO:0006865 0.141152195532121 0.241744612266927 2535 2514.90909090909 2376 0.0137378130327221 1404 1.32018948758027 1.4836078808557 1 3.09013494497543 2533 1834 1404 1850 1494 3918 3739 3540 1476 2376 3500 2323 M15190 GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. 14/45 Gene Ontology BP GO:0042743 0.187027798021324 0.291595052455677 2500 2416.63636363636 2376 0.0186474319978627 679 0.439380582319398 0.323505982548025 1 0.892648135701458 2499 731 2376 2432 2303 1893 679 4412 2205 4205 2848 2324 M15489 GO_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 36/79 Gene Ontology BP GO:0046677 0.200390392059216 0.307777899547119 1545 2566.72727272727 2376 0.0201248868055797 1392 1.51150060299028 1.51150060299028 1 2.93618944593899 1543 3742 1392 3350 1721 3642 2231 2376 4079 2629 1529 2325 M15204 GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 8/22 Gene Ontology BP GO:0006700 0.032091377089259 0.0904127814474693 2095 2579.18181818182 2377 0.00325644563986452 798 0.383357354274837 -0.216919533499392 -1 1.51885358669732 2091 2438 4369 2587 798 2290 2241 2891 2080 4209 2377 2326 M13146 GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that modulates I-kappaB kinase/NF-kappaB signaling. 192/420 Gene Ontology BP GO:0043122 0.161385165508919 0.258740097879113 2380 2541.09090909091 2378 0.0158730158730159 1487 1.27073952965721 1.34897291422262 1 2.83206146376726 2378 1761 2782 2561 2591 4507 2351 1487 1588 2311 3635 2327 M16535 GO_CORTICAL_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. 29/61 Gene Ontology BP GO:0030865 0.161385165508919 0.258740097879113 3990 2670.63636363636 2378 0.0158730158730159 1123 1.16182907351569 1.2384550818236 1 2.58933579209307 3986 1430 1333 1123 4127 2768 4605 2378 1463 1570 4594 2328 M12222 GO_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JAK_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. 55/201 Gene Ontology BP GO:0046425 0.098712924521525 0.180467567090794 2805 2328.63636363636 2379 0.009403818870992 1305 1.04765419421988 -0.726732765344982 -1 2.95709350002068 2803 1771 1329 1613 1305 4052 2549 1431 2379 2428 3955 2329 M13349 GO_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFIBRIL_ASSEMBLY.html Formation of myofibrils, the repeating units of striated muscle. 34/82 Gene Ontology BP GO:0030239 0.00520406097767018 0.0257194450017365 3585 2401.45454545455 2379 0.000474219273966316 504 2.2702248085889 -2.07333958077616 -1 13.6994068284078 3585 2452 504 2214 2379 1735 2649 3651 1994 1838 3415 2330 M14464 GO_DSRNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DSRNA_FRAGMENTATION.html Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. 12/29 Gene Ontology BP GO:0031050 0.383203248053165 0.504741186017261 2380 2571.81818181818 2380 0.0429778112541183 1075 0.206686703049187 -0.200559381188953 -1 0.232956956603429 2380 3150 3177 3557 2163 1175 1075 2029 4331 4023 1230 2331 M15845 GO_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of STAT cascade. 55/201 Gene Ontology BP GO:1904892 0.098712924521525 0.180467567090794 2805 2323.63636363636 2380 0.009403818870992 1306 1.04765419421988 -0.726732765344982 -1 2.95709350002068 2804 1772 1330 1614 1306 4053 2550 1365 2380 2430 3956 2332 M16759 GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA.html The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. 12/29 Gene Ontology BP GO:0070918 0.383203248053165 0.504741186017261 2385 2623.54545454545 2381 0.0429778112541183 1076 0.206686703049187 -0.200559381188953 -1 0.232956956603429 2381 3151 3178 3558 2164 1176 1076 2028 4332 4584 1231 2333 M10910 GO_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROTIC_CELL_DEATH.html A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. 27/55 Gene Ontology BP GO:0070265 0.0382408509227238 0.101400497335355 1480 2052.72727272727 2382 0.00353838188843732 609 1.86280643978199 1.86280643978199 1 7.02819547377987 1480 3145 2674 2757 2533 2382 2118 609 778 2488 1616 2334 M10946 GO_PEPTIDYL_SERINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_SERINE_MODIFICATION.html The modification of peptidyl-serine. 92/216 Gene Ontology BP GO:0018209 0.298735036746822 0.413174493778819 4565 2761.36363636364 2382 0.0317460317460317 1937 1.09454634742111 1.44307532154467 1 1.59485643792805 4562 2002 3101 2065 2211 1937 4441 2382 2116 2751 2807 2335 M13578 GO_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_GENOME_REPLICATION.html Any process involved directly in viral genome replication, including viral nucleotide metabolism. 15/31 Gene Ontology BP GO:0019079 0.0257763038692333 0.0784268537777523 3465 2364.81818181818 2382 0.00237121460253666 675 1.05017218735395 -0.650112755713168 -1 4.40697230354651 3462 1114 2382 1778 675 2512 4240 2241 2479 2075 3055 2336 M11623 GO_CELL_PROLIFERATION_IN_FOREBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION_IN_FOREBRAIN.html The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. 11/46 Gene Ontology BP GO:0021846 0.0161006237943656 0.056978045943018 2485 2325.18181818182 2383 0.00147451611424796 515 1.16186250822327 -1.16186250822327 -1 5.48762510766537 2483 2509 1563 2004 515 3341 2940 2248 3810 1781 2383 2337 M15977 GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. 53/146 Gene Ontology BP GO:0031098 0.0839184282471183 0.158445571591463 2960 2281.54545454545 2385 0.00793650793650794 952 1.83179983466004 1.83179983466004 1 5.56340037598402 1458 2958 2544 2957 4323 2549 1623 1023 952 2385 2325 2338 M10463 GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. 9/22 Gene Ontology BP GO:0033599 0.2476617625066 0.360694342320622 2390 2562 2386 0.0280558424238297 817 0.276482160643836 -0.311589625149594 -1 0.464773607279164 2386 3438 3590 3902 2081 1643 817 1882 4365 3035 1043 2339 M15673 GO_AXONEME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_ASSEMBLY.html The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 28/98 Gene Ontology BP GO:0035082 0.137195415577165 0.236450747782026 1480 2158.36363636364 2386 0.0133256038822358 455 1.09835599373909 -0.900270877697453 -1 2.61098603673467 1478 3347 2768 2975 1941 455 1836 2386 3092 2524 940 2340 M16578 GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. 13/33 Gene Ontology BP GO:0045940 0.00692697108875827 0.0312859209777283 3565 2387.81818181818 2386 0.000631716194517352 538 1.38916827744188 -1.38916827744188 -1 7.93410388650736 3564 819 538 1030 3278 3768 2386 2773 1712 1967 4431 2341 M16769 GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of tight junction assembly. 13/24 Gene Ontology BP GO:2000810 0.0105982300664707 0.0421658802044758 1225 2359 2386 0.000968148431992746 328 0.896585420808603 0.896585420808603 1 4.67965531645244 1222 3542 2386 3435 3121 2334 1054 328 2769 4587 1171 2342 M16907 GO_CORPUS_CALLOSUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORPUS_CALLOSUM_DEVELOPMENT.html The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. 18/36 Gene Ontology BP GO:0022038 0.0839184282471183 0.158445571591463 2520 2305.27272727273 2386 0.00793650793650794 758 1.41412268034735 1.41412268034735 1 4.29486371960404 2519 2386 1891 1689 2264 3756 3678 2838 758 1076 2503 2343 M11204 GO_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_PROLIFERATION.html The expansion of a B cell population by cell division. Follows B cell activation. 13/53 Gene Ontology BP GO:0042100 0.0597263664397718 0.138892220755598 3300 2389 2387 0.00558293413298844 618 2.24458518468169 2.24458518468169 1 7.30444681234715 3300 3395 1659 2387 3110 4020 3500 733 618 1929 1628 2344 M12968 GO_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 63/167 Gene Ontology BP GO:0090279 0.117685545365893 0.208714280799786 3175 2648.81818181818 2389 0.0113178981048579 1393 1.47487841420629 1.71879491013496 1 3.8094149926942 3174 3376 1543 2389 1393 3335 3454 2056 2047 1983 4387 2345 M15235 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 12/22 Gene Ontology BP GO:0030812 0.0265959776129454 0.0797535465009727 2920 2335.45454545455 2390 0.00244754978867026 685 0.471771918803303 -0.538846319682651 -1 1.96671091509181 2917 2506 1842 2835 685 1393 2390 3715 1626 4218 1563 2346 M11549 GO_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_PROLIFERATION.html The expansion of a muscle cell population by cell division. 14/33 Gene Ontology BP GO:0033002 0.0186232368096315 0.0630441631817949 2205 2533.09090909091 2391 0.00170752531812278 426 1.08918898596586 1.08918898596586 1 4.96272510824355 2203 2391 2301 2480 4442 3726 2976 426 2354 2012 2553 2347 M14221 GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is decreased. 14/46 Gene Ontology BP GO:0045776 0.111540009296278 0.199568502182126 1980 2578.27272727273 2392 0.0106938338877315 936 1.14082867248978 1.14082867248978 1 3.03087913336572 1979 2392 936 2605 1834 3957 4252 3305 2350 2028 2723 2348 M14397 GO_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 142/323 Gene Ontology BP GO:0006732 0.123532408421738 0.216929263351789 2800 2203.54545454545 2392 0.0119153118851496 423 0.998937367281385 -0.807464442219271 -1 2.51654926465963 2797 1265 2924 2392 2000 423 2749 3859 1584 2401 1845 2349 M16147 GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS.html The process in which the structure of the atrioventricular valve is generated and organized. 9/26 Gene Ontology BP GO:0003181 0.0765897756730953 0.158445571591463 2520 2335.81818181818 2392 0.00793650793650794 255 1.24967114279224 -0.791140711360448 -1 3.7954042652559 2518 1125 4518 1351 4568 2440 2392 2003 255 1631 2893 2350 M13654 GO_RECEPTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 44/123 Gene Ontology BP GO:0043112 0.000985614343186891 0.00802843402704691 3840 2037.72727272727 2393 8.96414710898775e-05 61 0.924125013784547 1.01546243314167 1 7.35018895309713 3839 61 1185 215 93 4267 2662 2393 722 2698 4280 2351 M15582 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. 12/19 Gene Ontology BP GO:0097296 0.102966099583565 0.186965819462844 1325 2446.72727272727 2393 0.00982969906683042 1265 1.86280643978199 1.86280643978199 1 5.1492996959394 3559 2077 2393 1265 1324 2872 2734 3888 1322 1888 3592 2352 M12015 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. 22/44 Gene Ontology BP GO:0002832 0.0142989403963874 0.0526380793457477 2620 2369.90909090909 2395 0.00130843010660863 379 1.31269689825659 1.31269689825659 1 6.37148028492425 2616 2106 2713 1865 3635 4613 3966 379 515 1266 2395 2353 M14416 GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. 11/18 Gene Ontology BP GO:2000001 0.0263466476901602 0.0793818852857974 1060 2148 2395 0.00242432382396999 168 0.276960071895415 -0.278787478045501 -1 1.15671683633716 1060 2395 3247 2739 4107 168 322 1729 3479 4007 375 2354 M15968 GO_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. 64/190 Gene Ontology BP GO:0048593 0.0839184282471183 0.158445571591463 865 2115.81818181818 2395 0.00793650793650794 862 1.30380456340125 1.48929918864604 1 3.95981409152652 2395 1725 1236 937 2589 3879 2597 2548 864 862 3642 2355 M13409 GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. 2/12 Gene Ontology BP GO:0070897 0.363803253390632 0.483855200656747 2510 2597.8 2397.5 0.0490080798239183 1084 0.196963474753318 -0.196963474753318 -1 0.235719585043911 2510 1507 4070 NA 4245 1418 1084 2285 3188 3732 1939 2356 M14747 GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein depolymerization. 14/30 Gene Ontology BP GO:1901881 0.0839184282471183 0.158445571591463 3700 2903.72727272727 2398 0.00793650793650794 895 1.63639951871907 1.63639951871907 1 4.96994569243248 3699 2390 1697 2398 4433 4510 3149 2368 895 2029 4373 2357 M11292 GO_HORMONE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_TRANSPORT.html The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 37/118 Gene Ontology BP GO:0009914 0.092990090114574 0.17194463894941 3960 2830.09090909091 2400 0.00883365225317082 894 1.40406503160402 -1.07272638267715 -1 4.07507119645247 3958 1428 894 2219 1509 4203 4494 3612 2400 1970 4444 2358 M13294 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP.html Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. 4/13 Gene Ontology BP GO:0045188 0.365460580342971 0.485503140066499 2325 2865.45454545455 2400 0.0444666251035603 1031 0.502981740189276 0.549337292956922 1 0.599133221205571 2321 3488 4046 3834 2265 2400 1031 2394 3653 3699 2389 2359 M16945 GO_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. 23/58 Gene Ontology BP GO:0019933 0.104661745741284 0.18900991267086 2490 2155.45454545455 2400 0.01 97 0.989700013025351 -0.665455983212677 -1 2.718057235564 2487 97 1368 1043 1638 3999 2668 1654 3317 2400 3039 2360 M11240 GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION.html The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. 7/14 Gene Ontology BP GO:0036508 0.000793497761661697 0.00695133982527408 975 2102.09090909091 2401 7.93781241548472e-05 21 0.380071619310322 -0.380071619310322 -1 3.11322366322722 974 2401 3714 3207 4521 21 36 1019 3857 3196 177 2361 M11518 GO_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_CHECKPOINT.html A cell cycle checkpoint that originates from the mitotic or meiotic spindle. 13/31 Gene Ontology BP GO:0031577 0.499834492694319 0.616396161906965 995 2287.09090909091 2402 0.0610408390567461 995 0.674350887224881 -0.674350887224881 -1 0.537900620585105 995 2571 2934 2402 2926 1213 1678 1732 3509 3278 1920 2362 M12900 GO_PROTEIN_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMANNOSYLATION.html The removal of one or more mannose residues from a mannosylated protein. 7/14 Gene Ontology BP GO:0036507 0.000793497761661697 0.00695133982527408 975 2161.27272727273 2402 7.93781241548472e-05 22 0.380071619310322 -0.380071619310322 -1 3.11322366322722 975 2402 3976 3208 4522 22 37 998 3858 3598 178 2363 M14135 GO_DETECTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS.html The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. 23/106 Gene Ontology BP GO:0009583 0.397847603699283 0.519169877452437 1190 2521.63636363636 2402 0.0450661003982303 713 1.28900484683081 1.28900484683081 1 1.39294759274983 1189 3913 2099 3411 3864 3314 2653 1813 2402 713 2367 2364 M16793 GO_PROGESTERONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROGESTERONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. 6/26 Gene Ontology BP GO:0042448 0.00524072389774304 0.0258034793819947 2790 2335.90909090909 2402 0.000525312441056186 273 0.530879381233561 -0.298549290546722 -1 3.20067491809498 2787 672 4619 1518 273 2402 1383 2615 1262 4594 3570 2365 M11053 GO_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 189/412 Gene Ontology BP GO:0051186 0.0764906601732042 0.158445571591463 3440 2350.54545454545 2403 0.00720793062390755 700 0.998937367281385 -0.807464442219271 -1 3.03389509018151 3436 760 3182 2364 1177 700 3511 3525 2094 2704 2403 2366 M13911 GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 148/357 Gene Ontology BP GO:0051091 0.244613262558415 0.357412705302232 3240 2492.27272727273 2403 0.0251798742767534 999 1.34164007192636 1.41694184906585 1 2.27554584178091 3238 999 1980 1381 1846 2364 3151 3142 2403 2449 4462 2367 M16820 GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. 15/23 Gene Ontology BP GO:1900025 0.298735036746822 0.413174493778819 4095 2750.36363636364 2403 0.0317460317460317 1902 1.02994163219373 1.02994163219373 1 1.50072132317929 4094 2748 2023 2403 4487 2082 2443 1902 2053 2087 3932 2368 M14057 GO_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION.html The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. 20/73 Gene Ontology BP GO:0030101 0.179779717300265 0.282285163146815 2405 2352.63636363636 2404 0.017855247929623 1072 1.21171025470624 1.21171025470624 1 2.52653349123983 2404 2636 2406 2013 3112 4290 1072 1151 2023 2294 2478 2369 M14360 GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 29/68 Gene Ontology BP GO:0030166 0.415320710913563 0.535202348257472 3695 2548.36363636364 2404 0.0476190476190476 1526 1.2325014110508 -1.41589619207923 -1 1.27009345985604 3694 1526 1678 2115 2615 2375 3584 3712 2404 1568 2761 2370 M16110 GO_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_PROLIFERATION.html The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. 16/52 Gene Ontology BP GO:0007405 0.126475577729307 0.220844718840606 2410 2336.90909090909 2404 0.0122174076727667 1289 1.65735694990685 1.65735694990685 1 4.12638276977807 2408 2072 2692 2406 1436 2497 2404 4232 2148 2122 1289 2371 M13875 GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. 48/104 Gene Ontology BP GO:0045639 0.0323570727280957 0.0909956927174733 2195 2391.09090909091 2407 0.00298572805306084 724 1.28983715113895 1.28983715113895 1 5.09664224748657 2195 1726 724 1255 3361 4511 1848 2407 2489 2737 3049 2372 M15836 GO_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that modulates the frequency, rate or extent of viral genome replication. 54/138 Gene Ontology BP GO:0045069 0.150811890221424 0.252878153231517 2410 2512.27272727273 2407 0.0147514383696917 1058 1.80025986648007 1.80025986648007 1 4.08019834045903 2199 3378 1453 3817 2539 3582 2000 1058 2407 2406 2796 2373 M11123 GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS.html A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism. 697/1598 Gene Ontology BP GO:0044711 0.0288443979723558 0.08370283736603 2935 2161.81818181818 2408 0.00292257835589033 553 1.23494706421441 1.40819558888995 1 5.04982159007645 2934 1258 3695 2578 756 553 2775 3970 1188 2408 1665 2374 M11856 GO_REGULATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 158/473 Gene Ontology BP GO:0042391 0.0114345562555164 0.0446890948605747 2220 2311.36363636364 2408 0.0010449476125007 297 1.44352515394701 1.50841461991557 1 7.39606142661366 2220 2408 585 1747 3113 3387 3514 3617 1115 297 3422 2375 M15324 GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 92/255 Gene Ontology BP GO:0043901 0.249529949350475 0.363073505118852 2555 2572.09090909091 2409 0.0257584008481751 1298 1.21623053547734 1.21623053547734 1 2.0313332712857 2552 1360 1893 2293 4105 4612 2001 1298 2409 2515 3255 2376 M12323 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of striated muscle contraction. 13/27 Gene Ontology BP GO:0045989 0.0987654723191271 0.180467567090794 4600 2485.72727272727 2410 0.00940906944578291 407 1.20368350482159 1.23564951345304 1 3.39749956412679 4599 2465 1077 1697 2410 2078 3846 2536 2168 407 4060 2377 M13966 GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of T cell proliferation. 42/104 Gene Ontology BP GO:0042130 0.337346803897849 0.45775991593735 2415 2463.27272727273 2410 0.0367183224091217 1241 1.21455215107271 1.21455215107271 1 1.56454088028095 2415 3739 1241 3637 2134 1266 2410 1987 3515 2684 2068 2378 M16546 GO_RESPONSE_TO_MANGANESE_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MANGANESE_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. 10/30 Gene Ontology BP GO:0010042 0.398775838999324 0.51979680529867 1350 2524.18181818182 2410 0.0452000177297858 965 0.363694380413489 -0.402968547328325 -1 0.392298400854135 1350 2825 2263 2704 3744 965 1744 2410 3933 4528 1300 2379 M10716 GO_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROPTOTIC_PROCESS.html A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. 24/46 Gene Ontology BP GO:0070266 0.0839184282471183 0.158445571591463 1850 2277.45454545455 2411 0.00793650793650794 684 1.86280643978199 1.86280643978199 1 5.657571232065 1846 3049 2594 2804 2818 3117 2377 1087 684 2411 2265 2380 M14281 GO_MESODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. 18/48 Gene Ontology BP GO:0048333 0.0839184282471183 0.158445571591463 2070 2563 2411 0.00793650793650794 902 1.9083122944764 1.9083122944764 1 5.79577808432812 2068 4017 2411 3427 2065 2389 2981 2938 902 2204 2791 2381 M15341 GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of cell projection assembly. 109/259 Gene Ontology BP GO:0060491 0.0586777794039027 0.137200667935398 3425 2607.27272727273 2411 0.0054821699788637 1043 1.05305167907728 1.13815636437093 1 3.44816793032985 3425 2335 1801 1714 1043 3230 3675 2966 2411 1835 4245 2382 M11498 GO_DRUG_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSMEMBRANE_TRANSPORT.html The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 11/45 Gene Ontology BP GO:0006855 0.361760669448159 0.481552404887558 3260 2223.90909090909 2413 0.04 564 0.463467739163578 -0.475791851946768 -1 0.55830827059911 3260 564 2431 1851 2664 2034 1202 2194 2413 3272 2578 2383 M15547 GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. 19/53 Gene Ontology BP GO:0045414 0.267702895101769 0.384455472303592 2565 2561.18181818182 2413 0.0279270748750167 1340 1.29644110978073 1.29644110978073 1 2.04300393213754 2563 1853 2413 1974 3937 3779 2712 1340 2157 2249 3196 2384 M10849 GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. 18/53 Gene Ontology BP GO:0002701 0.269952286777195 0.387446203247764 2370 2615.90909090909 2415 0.0281989009185578 1860 1.00744291305309 1.00744291305309 1 1.5747150806112 2368 2566 2247 2415 1906 3860 3047 1860 3147 2186 3173 2385 M12552 GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 79/187 Gene Ontology BP GO:0042990 0.415320710913563 0.535202348257472 3450 2673.72727272727 2415 0.0476190476190476 1158 1.14929723252902 1.31743882566073 1 1.18435150285671 3448 1215 2839 2020 4218 1158 4246 3253 2415 2340 2259 2386 M14504 GO_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 261/671 Gene Ontology BP GO:0008610 0.14084477784986 0.241485341047599 4455 2675.45454545455 2416 0.013705725104171 1262 1.09968952656314 -0.960986836217837 -1 2.57596145402833 4453 1262 2416 2066 1491 1825 4495 4369 1594 2864 2595 2387 M10386 GO_COGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COGNITION.html The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. 123/419 Gene Ontology BP GO:0050890 0.161385165508919 0.258740097879113 3940 2718 2417 0.0158730158730159 611 1.32462190212755 1.40025652045489 1 2.95214759243306 3936 2334 2224 1767 2417 2601 4411 4110 1489 611 3998 2388 M13729 GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. 6/24 Gene Ontology BP GO:0042753 0.0279542512913321 0.081990896238569 3105 2545.45454545455 2418 0.00283122540602858 738 1.31505585488108 1.31505585488108 1 5.42219296427599 3104 1993 4122 1637 738 3318 2418 2363 3072 1324 3911 2389 M14005 GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell. 44/145 Gene Ontology BP GO:0050715 0.0571629256734472 0.13534291886885 2420 2471 2418 0.00533677988914546 804 1.49867453025741 1.49867453025741 1 4.94102001732903 2418 2735 804 2853 1905 4346 3092 1012 2313 2170 3533 2390 M11842 GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. 11/54 Gene Ontology BP GO:0021522 0.415320710913563 0.535202348257472 3440 2732.54545454545 2419 0.0476190476190476 1783 1.48620652365728 -1.48620652365728 -1 1.53153673400506 3439 3478 1971 3516 3353 2156 2105 3720 2419 1783 2118 2391 M13707 GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. 18/43 Gene Ontology BP GO:2000300 0.0791164215558765 0.158445571591463 1870 2483.45454545455 2419 0.00746487641479353 329 0.369904866379056 -0.443023516117017 -1 1.12344636869936 1869 3751 2419 4007 4297 329 1656 1451 3201 3813 525 2392 M10684 GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 64/190 Gene Ontology BP GO:0032649 0.0515880591184435 0.12566807895432 2015 2444 2420 0.00480354718925021 785 1.42852305100822 1.42852305100822 1 4.88439546684918 2014 3773 785 3789 2611 3753 2265 1568 2420 861 3045 2393 M12875 GO_ENDOCRINE_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. 20/51 Gene Ontology BP GO:0031018 0.0839184282471183 0.158445571591463 2530 2437.54545454545 2420 0.00793650793650794 800 1.46584243959724 1.46584243959724 1 4.45194296080794 2530 1734 1617 2420 3275 4405 1948 2909 800 2290 2885 2394 M13668 GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. 271/607 Gene Ontology BP GO:0033157 0.0145558004263502 0.0530475521032528 3810 2301.90909090909 2420 0.00133209156183911 484 1.18614175436564 1.28544206026214 1 5.74206342428508 3809 1465 2420 1915 484 1225 4148 2498 2677 1164 3516 2395 M13933 GO_NADH_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_METABOLIC_PROCESS.html The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 21/54 Gene Ontology BP GO:0006734 0.0650636563652281 0.147211315059836 2280 2377.18181818182 2420 0.00609741066984288 277 0.354454241542944 -0.350607449909848 -1 1.11949312489862 2279 2420 2634 2818 3145 277 1667 2370 3508 3879 1152 2396 M12312 GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of adenylate cyclase activity. 21/86 Gene Ontology BP GO:0045761 0.144305263507996 0.246132854186195 3540 2724.81818181818 2421 0.0140675310248443 1007 0.936519733884973 -1.01405746558881 -1 2.16431516338989 3540 1539 1007 2369 3488 1110 4503 4525 3150 2321 2421 2397 M16430 GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. 41/80 Gene Ontology BP GO:0043525 0.00917251935236375 0.0381271328138092 2385 2631.09090909091 2421 0.000837362482964731 364 1.33838686015354 1.61112816865721 1 7.2077484682299 2383 3976 1747 2576 364 4191 2353 3601 2421 2097 3233 2398 M10103 GO_REGULATION_OF_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GOLGI_ORGANIZATION.html Any process that modulates the frequency, rate or extent of Golgi organization. 7/19 Gene Ontology BP GO:1903358 0.051912461956038 0.126061485806425 2425 2228.72727272727 2422 0.00531666039352698 1026 1.69748649654937 1.69748649654937 1 5.79528676116171 2422 2141 3533 1569 1026 2877 2554 2608 1649 1390 2747 2399 M10661 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. 6/23 Gene Ontology BP GO:0051818 0.00592224653212775 0.0281731461564233 1875 2342.54545454545 2422 0.000593808883690271 292 0.5746995415338 -0.28244306297727 -1 3.381628626019 1875 1192 3615 1658 292 3520 2422 3536 2471 3067 2120 2400 M11253 GO_PHOTOTRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION.html The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. 15/64 Gene Ontology BP GO:0007602 0.232850105696956 0.342669743502683 1280 2353.63636363636 2422 0.0238095238095238 958 1.1873363381586 1.1873363381586 1 2.09628325105968 1276 3286 2422 3100 3483 2918 2122 2463 1849 958 2013 2401 M10415 GO_SKELETAL_MUSCLE_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_TISSUE_REGENERATION.html The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. 23/42 Gene Ontology BP GO:0043403 0.0240851591030663 0.0748509998095962 2835 2132.27272727273 2423 0.00221390474029774 158 0.363818173985273 -0.393641673732483 -1 1.55472573991764 2831 2209 2423 2603 1610 158 871 2997 3703 3021 1029 2402 M12704 GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 20/39 Gene Ontology BP GO:0042558 0.0839184282471183 0.158445571591463 3635 2757.81818181818 2423 0.00793650793650794 344 0.964916235402726 -0.810865129405406 -1 2.93056874725372 3635 2423 2349 2329 3736 2244 3606 3827 344 2289 3554 2403 M15234 GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. 6/23 Gene Ontology BP GO:0051883 0.00592224653212775 0.0281731461564233 1880 2516.36363636364 2423 0.000593808883690271 293 0.5746995415338 -0.28244306297727 -1 3.381628626019 1876 1193 4374 1659 293 3521 2423 3531 2472 4217 2121 2404 M16272 GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. 9/30 Gene Ontology BP GO:0032332 0.00201073147810281 0.0130206781768917 3345 2359.90909090909 2423 0.000201255316686925 149 1.23366081505784 1.15561552412385 1 8.82874073265847 3345 1611 4539 1095 149 2800 3970 3413 1931 683 2423 2405 M12526 GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. 9/23 Gene Ontology BP GO:0021681 0.0618257138914785 0.142107321583235 2425 2331 2424 0.00636163269892146 490 1.51935086267539 -1.51935086267539 -1 4.8870337096601 2424 3190 3924 2510 2445 1873 2178 3020 1989 1598 490 2406 M10932 GO_T_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 25/50 Gene Ontology BP GO:0043029 0.038638363211631 0.102224539436006 3085 2440.54545454545 2425 0.00357583032821216 355 2.05369581223184 2.05369581223184 1 7.72100157819178 3082 3594 2256 2425 839 4575 4612 744 355 1379 2985 2407 M12466 GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. 21/50 Gene Ontology BP GO:0001953 0.0839184282471183 0.158445571591463 2430 2684.81818181818 2427 0.00793650793650794 1108 1.19045135446987 1.19045135446987 1 3.6155465174851 2427 3597 1861 1908 3296 4248 3032 2235 1108 2322 3499 2408 M14372 GO_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that modulates the frequency, rate or extent of the transcription of the viral genome. 34/86 Gene Ontology BP GO:0046782 0.179656537407441 0.282282674511929 3255 2741.72727272727 2429 0.0178418399763381 1424 0.346657918243193 -0.375223383455178 -1 0.722820444591099 3254 1429 3220 2374 1651 2130 4189 4067 2429 3992 1424 2409 M16265 GO_RESPONSE_TO_MISFOLDED_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MISFOLDED_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. 7/17 Gene Ontology BP GO:0051788 0.191248756126661 0.29727752751794 2430 2616.90909090909 2429 0.0210026952451978 613 0.395346547048591 -0.401906097055518 -1 0.790609825317279 2429 2363 4538 3204 3523 613 1308 1692 3414 4456 1246 2410 M14264 GO_PROTEIN_DEGLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEGLYCOSYLATION.html The removal of sugar residues from a glycosylated protein. 11/22 Gene Ontology BP GO:0006517 2.87941299879599e-05 0.000564097660481425 555 1963.45454545455 2430 2.6176824417614e-06 4 0.354729764772665 -0.354729764772665 -1 4.37428637129081 553 2430 2838 3074 3992 16 4 1070 3596 3963 62 2411 M16076 GO_POSITIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the cell cycle. 202/497 Gene Ontology BP GO:0045787 0.00859467680250093 0.0365431175769339 3640 2488.36363636364 2430 0.000784403470621264 349 1.30683512771278 1.39542947191825 1 7.12924514602759 3636 3519 1440 2168 349 2251 2972 3749 2430 757 4101 2412 M12852 GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 47/96 Gene Ontology BP GO:0070301 0.00154043591803349 0.0106590819186729 2850 2328.54545454545 2431 0.000140137780629861 123 1.33234111723743 1.33234111723743 1 9.97450326213437 2850 1578 1216 1261 123 4027 3450 2764 2431 2262 3652 2413 M11854 GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. 59/129 Gene Ontology BP GO:1901800 0.0377395248392865 0.100357739879042 2480 2481 2432 0.00349117352049617 826 0.915449771924354 1.12647814950733 1 3.46950640699795 2477 2877 2339 3222 826 4415 2280 1372 2432 2790 2261 2414 M15890 GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). 22/109 Gene Ontology BP GO:0007189 0.0508072281386078 0.124287650288491 2435 2607.27272727273 2432 0.00472908879159787 975 0.858982002181133 0.858982002181133 1 2.9526657879558 2432 1382 1145 2655 975 3890 1975 4555 2416 4373 2882 2415 M12775 GO_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 56/118 Gene Ontology BP GO:0038127 0.0585076460607432 0.137059031614546 2720 2385.27272727273 2434 0.00546583060772568 1042 1.29018372205382 1.29018372205382 1 4.22684236847802 2718 1315 1857 1409 1042 3376 2277 3497 2523 2434 3790 2416 M13587 GO_GOLGI_TO_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_ENDOSOME_TRANSPORT.html The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. 14/27 Gene Ontology BP GO:0006895 0.385259602091338 0.506813899861537 2925 2464.72727272727 2434 0.0432683099387994 1286 0.94175740835774 0.94175740835774 1 1.05509422389403 2925 2218 3062 2434 2172 1286 1407 3442 2572 3780 1814 2417 M13418 GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 5/19 Gene Ontology BP GO:0001963 0.0166381979805227 0.0582148856243909 2435 2555 2435 0.00167641000525785 561 0.262812175599865 -0.311006609170611 -1 1.2319914575503 2435 1949 4072 2803 561 1978 1344 3973 3561 3736 1693 2418 M14562 GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 11/34 Gene Ontology BP GO:0045663 0.0689122933896001 0.153752896784197 1845 2729.90909090909 2435 0.00647005115619698 416 0.255993300556434 0.283939826548865 1 0.790170393710271 1845 4102 2435 4272 3323 1843 416 1605 4448 4045 1695 2419 M10042 GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL.html A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. 25/78 Gene Ontology BP GO:0097553 0.0630663823205308 0.144268758678897 2060 2506.18181818182 2436 0.00590457587169982 751 1.29994081892301 1.29994081892301 1 4.14894640947405 2058 4011 1476 3690 1362 4351 3369 751 1550 2436 2514 2420 M16241 GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX.html The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. 7/13 Gene Ontology BP GO:0016558 0.310380692538568 0.427245050535597 2010 2821.63636363636 2436 0.0364795399266046 861 0.199145870469949 -0.227167095931657 -1 0.27918034738019 2008 4349 4533 4072 2436 861 1046 1847 4244 4449 1193 2421 M11638 GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. 4/15 Gene Ontology BP GO:0045628 0.365285130021008 0.485408946390252 1425 2496.81818181818 2440 0.0444402078665804 1030 0.401242800671237 0.526424927037421 1 0.478073906813476 1425 3558 3779 3496 2440 1347 1030 1631 3769 3304 1686 2422 M12018 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. 205/532 Gene Ontology BP GO:0000226 0.0897668038021482 0.166848386730734 2325 2518.27272727273 2441 0.00851395404718499 353 0.991925414429969 -0.76408081734606 -1 2.92810101602189 2323 4276 2715 4449 1562 353 2441 2044 3617 2884 1037 2423 M12946 GO_RESPONSE_TO_AMPHETAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMPHETAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. 17/46 Gene Ontology BP GO:0001975 0.021203618196505 0.0683194998517507 1620 2230.18181818182 2441 0.00194643450595353 461 0.383597624765478 0.39776612663072 1 1.69698799366606 1620 2113 2441 2883 694 2748 3161 461 2873 3612 1926 2424 M14370 GO_RESPONSE_TO_CORTICOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. 12/34 Gene Ontology BP GO:0051412 0.12018678560695 0.212016430688856 1215 2393.18181818182 2443 0.0115730250158062 533 1.05077947290469 1.05077947290469 1 2.68683218267513 1215 3545 2443 3853 2852 1963 533 2659 3117 1879 2266 2425 M10583 GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 2/13 Gene Ontology BP GO:0010455 0.0692024938784801 0.154030287189733 3270 2328.2 2443.5 0.00793650793650794 7 1.29829314601985 -1.29829314601985 -1 4.00356271231117 3267 320 3608 NA 4173 3997 1620 4589 7 845 856 2426 M15869 GO_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of sprouting angiogenesis. 23/46 Gene Ontology BP GO:1903670 0.0839184282471183 0.158445571591463 2000 2402.90909090909 2444 0.00793650793650794 995 1.19045135446987 1.19045135446987 1 3.6155465174851 1996 1594 2444 1477 2458 3547 3494 3561 995 2396 2470 2427 M13417 GO_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. 18/65 Gene Ontology BP GO:0042461 0.161385165508919 0.258740097879113 4085 2839.45454545455 2445 0.0158730158730159 1067 1.19951281013891 1.40369885952815 1 2.67332047645781 3163 2214 2077 2445 4551 4084 3968 2252 1328 1067 4085 2428 M16606 GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL.html The directed movement of calcium ion into a cytosol. 25/78 Gene Ontology BP GO:1902656 0.0804715844473696 0.158445571591463 2060 2514.63636363636 2445 0.00759774755080427 826 1.29994081892301 1.29994081892301 1 3.94807942648459 2059 4012 1477 3691 1363 4352 3370 826 1551 2445 2515 2429 M16775 GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 13/17 Gene Ontology BP GO:0010839 0.107746133192449 0.193976462354611 1070 2381.36363636364 2445 0.0103105312494854 1070 1.0923235667937 1.0923235667937 1 2.9531913060456 1070 3147 2445 3118 1349 2775 2211 3112 3360 1968 1640 2430 M16748 GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structure of the retina is generated and organized. 23/80 Gene Ontology BP GO:0060042 0.298735036746822 0.413174493778819 4445 2703.45454545455 2446 0.0317460317460317 1692 1.05398004901363 -0.792904243146179 -1 1.53574754561143 4441 1692 2042 2048 3097 2951 3385 2446 1968 2398 3270 2431 M12137 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 15/30 Gene Ontology BP GO:0051985 0.254096213802467 0.367987748186169 585 2141.72727272727 2447 0.0262987889864245 585 0.674350887224881 -0.674350887224881 -1 1.11134683070791 585 2819 2568 2447 2641 846 1497 1315 3993 3420 1428 2432 M16236 GO_SNRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. 42/91 Gene Ontology BP GO:0016073 0.149230131237461 0.250950923337751 1405 2569.63636363636 2448 0.0145847435492043 482 0.238777444880482 -0.257358470825693 -1 0.544188447441037 1405 2448 3431 3166 4432 482 2195 1326 3792 4447 1142 2433 M16677 GO_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERK1_AND_ERK2_CASCADE.html An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 14/29 Gene Ontology BP GO:0070371 0.323615456347737 0.442576307458776 1445 2493 2448 0.0349205648649739 1443 0.484397527781092 -0.321746329065486 -1 0.6509189796808 2927 1443 1445 1830 2049 3188 1575 2592 2448 4561 3365 2434 M11807 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. 18/47 Gene Ontology BP GO:0010881 0.495477356131696 0.6121610868865 1910 2887.09090909091 2450 0.0603001637545732 1294 1.38933387508025 1.38933387508025 1 1.12400220519494 1909 4410 2638 4401 4556 2450 1294 1724 3800 2191 2385 2435 M10461 GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. 5/23 Gene Ontology BP GO:0003148 0.0123321457892435 0.0471260517691008 3850 2337.18181818182 2451 0.00124011219497053 316 1.07272638267715 -1.07272638267715 -1 5.40233697458854 3847 316 3589 557 466 4382 2451 3027 1260 1178 4636 2436 M13203 GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE.html Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 21/43 Gene Ontology BP GO:0072595 0.0479045693969283 0.118890959210725 1295 2445 2451 0.00445278473422428 241 0.671837249370926 -0.671837249370926 -1 2.35853953293688 1295 3427 3109 3696 2451 241 1801 2253 4116 3670 836 2437 M14592 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 25/80 Gene Ontology BP GO:0051926 0.0839184282471183 0.158445571591463 3040 2412.27272727273 2451 0.00793650793650794 408 1.64461995956165 1.64461995956165 1 4.99491217774954 3037 3002 1048 1970 2154 4231 4448 2451 408 791 2995 2438 M11317 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. 69/144 Gene Ontology BP GO:0097191 0.0583314859042104 0.136862863688804 2285 2276 2452 0.0054489152580318 568 1.7138220554646 1.7138220554646 1 5.6187939666404 2283 2617 2857 1886 2452 4385 3166 725 568 1437 2660 2439 M12193 GO_SEXUAL_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEXUAL_REPRODUCTION.html A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. 320/1219 Gene Ontology BP GO:0019953 0.084829314834595 0.159694043832238 4525 2956.54545454545 2452 0.00802622464052031 336 1.42385529264322 1.86472899382469 1 4.30600026166436 4525 4579 2135 4339 1230 336 4276 4388 2452 2409 1853 2440 M10393 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM.html A process in which an organism has a negative effect on the functioning of the second organism's cells. 9/82 Gene Ontology BP GO:0044364 0.0232127608067695 0.0728884748208125 1690 2423.81818181818 2453 0.00234588611430169 666 0.439665296258203 -0.204094134453193 -1 1.89810470586214 1689 1743 3578 2255 666 3400 2453 3484 2733 3016 1645 2441 M11320 GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM.html Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 9/82 Gene Ontology BP GO:0031640 0.0232127608067695 0.0728884748208125 1690 2454.90909090909 2454 0.00234588611430169 667 0.439665296258203 -0.204094134453193 -1 1.89810470586214 1690 1744 3730 2256 667 3401 2454 3460 2734 3222 1646 2442 M10368 GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. 45/129 Gene Ontology BP GO:0002821 0.168860304256869 0.269052296727743 1745 2405.09090909091 2455 0.0166737369140487 1042 1.11882204112119 1.11882204112119 1 2.42140536964451 1744 3528 2198 3650 1602 1930 1042 2455 2792 2710 2805 2443 M12711 GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized during embryonic development. 16/43 Gene Ontology BP GO:0048596 0.0839184282471183 0.158445571591463 4550 2623.63636363636 2456 0.00793650793650794 552 1.2692844111372 -1.07272638267715 -1 3.85497216259023 4546 1855 1502 2133 2456 4598 2683 3805 552 1004 3726 2444 M13264 GO_NEUTRAL_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. 9/30 Gene Ontology BP GO:0046461 0.300496667520226 0.415239889076313 1905 2706.18181818182 2456 0.035107393155283 1721 0.622022167514871 0.74494589418007 1 0.901231401745742 1903 3071 4040 3258 2052 2456 1721 1763 3392 3688 2424 2445 M14119 GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a virus effects a change in the structure or processes of its host organism. 27/58 Gene Ontology BP GO:0019048 0.0353376911657982 0.0961785994461194 3595 2214.36363636364 2457 0.00326530978034459 701 1.84601786585865 1.84601786585865 1 7.12575001259033 3591 1589 1622 2457 800 701 2736 3732 2814 1476 2840 2446 M14211 GO_ACYLGLYCEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 9/30 Gene Ontology BP GO:0046464 0.300496667520226 0.415239889076313 1905 2744.45454545455 2457 0.035107393155283 1722 0.622022167514871 0.74494589418007 1 0.901231401745742 1904 3072 4205 3259 2053 2457 1722 1753 3393 3946 2425 2447 M15727 GO_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMPORT_INTO_CELL.html The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 18/59 Gene Ontology BP GO:0098657 0.35943518917414 0.479556776820555 4060 2550.90909090909 2457 0.0396825396825397 549 1.38933387508025 1.38933387508025 1 1.68314785526963 4059 549 2178 1949 3770 2466 2943 2457 2163 2210 3316 2448 M10468 GO_CELLULAR_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 26/70 Gene Ontology BP GO:0006073 0.0839184282471183 0.158445571591463 2880 2518.72727272727 2458 0.00793650793650794 644 1.70956702222945 1.70956702222945 1 5.19216435893213 2879 2062 2390 1899 1771 4218 2797 2748 644 2458 3840 2449 M11388 GO_MONOVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 164/504 Gene Ontology BP GO:0015672 0.0839184282471183 0.158445571591463 3050 2144.45454545455 2459 0.00793650793650794 346 1.36997874972216 1.53236643093132 1 4.16079319748775 3049 346 1331 805 2459 2615 4069 3268 844 454 4349 2450 M11731 GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/100 Gene Ontology BP GO:0032370 0.184879171472059 0.288890716278526 1055 2216.27272727273 2459 0.0184119289935447 896 0.366245395063522 0.466035466220663 1 0.749691828179792 1054 3348 2459 3153 3788 1151 1007 1160 3033 3330 896 2451 M15714 GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 127/307 Gene Ontology BP GO:0043244 0.0707043253263952 0.156780497330599 2460 2224.90909090909 2460 0.00664404090914751 298 0.887933044932833 -0.758283505231832 -1 2.71222520978228 2460 3038 1591 2861 3422 298 2191 2052 3052 2904 605 2452 M10755 GO_TRANSITION_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSPORT.html The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 46/122 Gene Ontology BP GO:0000041 0.415320710913563 0.535202348257472 2225 2779.09090909091 2461 0.0476190476190476 2009 1.11411327948172 -0.887765837354197 -1 1.14809441766166 2461 2009 2595 3067 4077 2224 4056 3436 2388 2222 2035 2453 M13270 GO_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of chemokine production. 48/124 Gene Ontology BP GO:0032642 0.156762749027599 0.258740097879113 2865 2553.63636363636 2461 0.0153811130278002 1093 1.38114177468899 1.38114177468899 1 3.07811184340074 2863 1925 1519 2285 2709 4176 3262 1093 2461 2272 3525 2454 M15003 GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 43/87 Gene Ontology BP GO:0030148 0.35943518917414 0.479556776820555 1700 2485.18181818182 2461 0.0396825396825397 1387 0.967459383376804 -0.967459383376804 -1 1.17205605889545 1700 1960 2461 2932 2822 1387 2602 3165 2318 4154 1836 2455 M12168 GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. 11/24 Gene Ontology BP GO:0051446 0.232850105696956 0.342669743502683 3925 2822.18181818182 2462 0.0238095238095238 772 1.42750535851956 -1.38916827744188 -1 2.52030993892252 3924 3361 1529 2235 2462 3538 2372 4504 1714 772 4633 2456 M11365 GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 26/67 Gene Ontology BP GO:0032480 0.00293699965116307 0.0171097733755962 4335 2286.54545454545 2463 0.000267357080824616 180 0.938287302278443 1.06710845596515 1 6.29244722556828 4335 792 2776 1283 180 3691 3124 1029 1460 2463 4019 2457 M12011 GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION.html Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. 7/24 Gene Ontology BP GO:0071675 0.0550473074935764 0.131566902405086 1160 2409.09090909091 2463 0.00564604221213804 736 0.577479151491324 0.683987351541921 1 1.93084384087684 1158 3193 3841 2492 4239 2463 1217 736 2007 3391 1763 2458 M13913 GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 18/47 Gene Ontology BP GO:0051954 0.113189865883769 0.201898020475735 2355 2806 2464 0.0108609865162447 942 0.650112755713168 -0.650112755713168 -1 1.71473965852625 2352 2022 2464 1983 1432 4394 4521 942 3237 3872 3647 2459 M14161 GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 95/262 Gene Ontology BP GO:0071241 0.00462953534262264 0.0238567509387313 1525 2228.18181818182 2464 0.000421755111839416 490 1.73555469449145 1.73555469449145 1 10.6880985455913 1523 3735 490 3689 3337 2543 681 1567 2464 2536 1945 2460 M11239 GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. 91/245 Gene Ontology BP GO:0022408 0.00914894243162292 0.0380632076254706 1265 2343.09090909091 2465 0.000835201119312847 564 1.20440940213754 1.20440940213754 1 6.4895579939395 1263 3270 564 2956 2375 2954 1946 3023 2465 2505 2453 2461 M12548 GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 6/13 Gene Ontology BP GO:0043650 0.25141607945078 0.365131328398489 2975 2480.27272727273 2465 0.02854195443477 1317 1.23889395501682 -1.23889395501682 -1 2.05764263099317 2973 3226 3929 2473 2465 2169 2291 1350 3193 1317 1897 2462 M11111 GO_LYMPH_NODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_NODE_DEVELOPMENT.html The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. 8/17 Gene Ontology BP GO:0048535 0.0765897756730953 0.158445571591463 3110 2457.36363636364 2466 0.00793650793650794 158 1.700555425947 1.700555425947 1 5.16479503767825 3106 1250 3693 997 3718 3729 2466 2408 158 1498 4008 2463 M12167 GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 83/200 Gene Ontology BP GO:0002221 0.415320710913563 0.535202348257472 2160 2598.36363636364 2466 0.0476190476190476 1608 1.18199903029656 1.18199903029656 1 1.21805072551354 2159 2479 1830 2635 4037 3808 1608 1848 2466 2402 3310 2464 M12331 GO_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 26/70 Gene Ontology BP GO:0044042 0.0839184282471183 0.158445571591463 2880 2519.72727272727 2466 0.00793650793650794 645 1.70956702222945 1.70956702222945 1 5.19216435893213 2880 2063 2391 1900 1772 4219 2798 2742 645 2466 3841 2465 M11580 GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that activates or increases the frequency, rate, or extent of a homeostatic process. 110/279 Gene Ontology BP GO:0032846 0.0985652513897366 0.180456806862203 2295 2431.27272727273 2467 0.00938906486471308 890 1.15352024972117 1.2561180805464 1 3.25602287351054 2294 4005 1242 2849 1935 3507 2153 890 2591 2811 2467 2466 M13307 GO_CELL_DIFFERENTIATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_HINDBRAIN.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. 14/41 Gene Ontology BP GO:0021533 0.102172483784787 0.185742694680019 2125 2621.45454545455 2467 0.0097500933834286 446 1.28836660323947 -1.27502197741866 -1 3.57533300912917 3827 3213 918 2121 3979 4392 3081 2467 2268 446 2124 2467 M14034 GO_SYNAPTIC_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_SIGNALING.html Cell-cell signaling to or from a synapse. 168/577 Gene Ontology BP GO:0099536 0.0839184282471183 0.158445571591463 1750 2542.27272727273 2467 0.00793650793650794 1203 1.27432267584648 -1.06998095111577 -1 3.87027398937745 1746 2767 2324 2551 2467 3931 2284 3504 1203 1975 3213 2468 M15577 GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. 151/364 Gene Ontology BP GO:0006091 0.160179238548908 0.258740097879113 2470 2511.45454545455 2467 0.0157444477761406 850 1.34645699228872 1.60716864120088 1 3.00081084399956 2467 1468 3357 3070 1575 850 2809 4516 2456 2813 2245 2469 M15726 GO_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. 78/292 Gene Ontology BP GO:0006338 0.295767986156351 0.413174493778819 1425 2488.54545454545 2467 0.0313743205640673 1223 1.28599801517266 -0.84157669908996 -1 1.87381943078705 1423 4121 1290 4247 4273 1223 2507 1392 2467 2852 1579 2470 M13832 GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM.html A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. 129/471 Gene Ontology BP GO:0022412 0.0266434171929597 0.0797584693919484 3400 2546 2468 0.00245196956584239 687 1.72872216303153 1.89835332595537 1 7.20647759172975 3399 4246 2468 2973 687 838 3405 4353 1817 1671 2149 2471 M16594 GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process that decreases the concentration of calcium ions in the cytosol. 8/20 Gene Ontology BP GO:0051481 0.670748189439649 0.762184004789106 1610 2642.90909090909 2469 0.105144694789299 1535 1.38933387508025 1.38933387508025 1 0.62197883100912 1608 1615 4589 3206 4024 2518 2085 2057 3366 1535 2469 2472 M12052 GO_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. 43/117 Gene Ontology BP GO:0030183 0.0839184282471183 0.158445571591463 3065 2176 2470 0.00793650793650794 919 2.24458518468169 2.24458518468169 1 6.81708002379904 1885 2485 2470 3062 1545 3064 3246 1317 919 2691 1252 2473 M11418 GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. 9/21 Gene Ontology BP GO:0019359 0.419619058182643 0.539095541544552 2680 2458 2471 0.0529534762360354 1138 1.08991325512181 1.08991325512181 1 1.11013371022819 2677 1943 3742 2471 2389 1206 1138 3597 3556 1590 2729 2474 M14100 GO_REGULATION_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. 592/1431 Gene Ontology BP GO:0032880 0.0723916714682185 0.158445571591463 2475 2534.72727272727 2471 0.00748640571897153 1195 1.17182745002507 1.30683231514502 1 3.55898343944933 2471 2040 4186 2530 1195 1672 3378 2081 2698 1832 3799 2475 M14488 GO_NEGATIVE_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JNK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. 26/66 Gene Ontology BP GO:0046329 0.0839184282471183 0.158445571591463 2990 2475.18181818182 2471 0.00793650793650794 792 2.35459573801311 2.35459573801311 1 7.1511955435219 2986 2626 2037 1912 1440 4262 2914 2366 792 2471 3421 2476 M13699 GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 5/17 Gene Ontology BP GO:0010759 0.278344398439358 0.39569903305387 2075 2735.36363636364 2472 0.0320944085969347 1400 0.54050403984917 0.693367632172063 1 0.826071637798176 2072 3411 4119 2785 2420 3366 1989 1400 2247 3808 2472 2477 M16385 GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. 9/21 Gene Ontology BP GO:0019363 0.419619058182643 0.539095541544552 2680 2536.27272727273 2472 0.0529534762360354 1139 1.08991325512181 1.08991325512181 1 1.11013371022819 2678 1944 4555 2472 2390 1207 1139 3595 3557 1632 2730 2478 M12126 GO_MELANIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. 5/18 Gene Ontology BP GO:0006582 0.0568566715106502 0.134824068347267 4210 2383.09090909091 2473 0.00583660205661342 27 2.24458518468169 2.24458518468169 1 7.41444516544861 4210 1296 3854 1163 1076 3781 3600 2473 27 1196 3538 2479 M14115 GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 16/23 Gene Ontology BP GO:0014733 0.142092808244163 0.243176155059952 3130 2455.36363636364 2474 0.0138360580715837 1002 2.00797681532615 -3.11553755502548 -1 4.68047769364134 3126 1331 1002 1958 3019 3014 4561 1308 2474 2117 3099 2480 M11093 GO_OOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOGENESIS.html The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. 35/107 Gene Ontology BP GO:0048477 0.0745215457349367 0.158445571591463 4570 2515.90909090909 2475 0.00701567691209436 282 1.76816527145432 2.02063556096797 1 5.37013441636501 4570 3091 1162 775 2446 2475 4020 4045 282 363 4446 2481 M14989 GO_LYTIC_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. 40/73 Gene Ontology BP GO:0080171 0.110453303082086 0.197852888198351 2045 2279 2475 0.0105838900299124 397 2.06322935667965 2.06322935667965 1 5.51081872998268 2042 3207 2695 2475 2767 397 1489 3471 2058 2670 1798 2482 M13340 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 151/356 Gene Ontology BP GO:0090068 0.0161470316577383 0.057077071461339 3580 2399.09090909091 2476 0.00147879781851785 517 1.33194218322629 1.4155269520122 1 6.28712038910106 3580 2730 988 1644 517 2476 3436 3872 2084 686 4377 2483 M14815 GO_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_FUSION.html The joining of two or more lipid bilayer membranes that surround a cell. 11/32 Gene Ontology BP GO:0045026 0.0839184282471183 0.158445571591463 3745 2434.72727272727 2476 0.00793650793650794 194 0.457143813480911 -0.403384351302385 -1 1.38840173223798 3743 1607 2476 1818 1457 2700 2384 2971 194 4103 3329 2484 M16410 GO_LYSOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. 40/73 Gene Ontology BP GO:0007040 0.110453303082086 0.197852888198351 2045 2280.09090909091 2476 0.0105838900299124 398 2.06322935667965 2.06322935667965 1 5.51081872998268 2043 3208 2696 2476 2768 398 1490 3473 2059 2671 1799 2485 M12245 GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myeloid cell differentiation. 119/290 Gene Ontology BP GO:0045637 0.0523455836875373 0.126649580542593 2480 2447.81818181818 2477 0.00487583641445351 787 1.65170568823415 1.65170568823415 1 5.62631629268322 2262 2477 787 1719 3538 4643 1906 2860 1007 2477 3250 2486 M12339 GO_REGULATION_OF_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_AGGREGATION.html Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. 10/26 Gene Ontology BP GO:0090330 0.0143894839336118 0.0527728071909633 1890 2477.90909090909 2477 0.00131677016451675 380 0.858982002181133 0.858982002181133 1 4.1656495675244 1886 2221 1577 2477 4410 3273 2627 380 2844 3467 2095 2487 M16068 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. 14/30 Gene Ontology BP GO:1901380 0.161385165508919 0.258740097879113 3170 2606.18181818182 2478 0.0158730158730159 1414 1.42279293755586 -1.42279293755586 -1 3.17093861909374 3168 1858 2478 1716 3883 2371 3781 3408 1414 2034 2557 2488 M16303 GO_PENTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. 6/18 Gene Ontology BP GO:0019321 0.275742742869669 0.392721949430635 2665 2547.27272727273 2478 0.0317460317460317 969 0.477079368636348 -0.288517632475327 -1 0.735076908285463 2665 1348 4544 1896 3164 2478 969 1437 1939 4466 3114 2489 M10659 GO_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 67/162 Gene Ontology BP GO:0042157 0.116773307696952 0.207413338805259 3285 2381.09090909091 2479 0.0112250133200713 504 1.20449043128958 -0.852138153649158 -1 3.12345407004207 3285 1924 3114 2479 1388 504 2569 4052 2251 2820 1806 2490 M10491 GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. 151/367 Gene Ontology BP GO:0032886 0.241186433079867 0.352780217512473 2485 2509.27272727273 2482 0.0247786741529678 677 0.890873115521218 -0.718845396418418 -1 1.53016270976305 2482 3934 1777 3760 2480 677 2537 2013 3618 2812 1512 2491 M12491 GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 18/41 Gene Ontology BP GO:0035710 0.161385165508919 0.258740097879113 3565 2671.81818181818 2482 0.0158730158730159 1065 0.999874348461293 0.984464976610968 1 2.22839184958901 3563 1789 1625 2482 4428 3431 3158 1980 1504 1065 4365 2492 M14168 GO_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING.html Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. 113/252 Gene Ontology BP GO:0016458 0.469114257113521 0.583316753119709 1190 2485.45454545455 2483 0.055938913771372 1077 1.27765529567575 -1.0878044685602 -1 1.13530902174669 1187 3617 2985 4255 2327 1077 2483 1754 3054 2824 1777 2493 M13476 GO_DETOXIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETOXIFICATION.html Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. 35/97 Gene Ontology BP GO:0098754 0.307130712235384 0.423454624973038 2485 2479.63636363636 2485 0.0328056395535431 1371 1.03069309216194 -1.03069309216194 -1 1.46005839054983 2485 1638 1371 3027 2010 3216 1705 3045 2304 2618 3857 2494 M10278 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 27/52 Gene Ontology BP GO:0042771 0.0348403414748665 0.0955078729381172 3350 2084.63636363636 2486 0.00321860388783018 344 1.05077947290469 1.05077947290469 1 4.06820007690272 808 3349 2764 3346 3709 345 566 1728 3486 2486 344 2495 M10803 GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. 75/152 Gene Ontology BP GO:0034250 0.0608286729141045 0.140721239830686 4360 2595.90909090909 2486 0.00568897066602761 757 1.49293299794252 1.49293299794252 1 4.82618290099725 4357 1829 2254 3424 1062 757 3945 3512 2671 2258 2486 2496 M16645 GO_ORGANELLE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_DISASSEMBLY.html The disaggregation of an organelle into its constituent components. 121/263 Gene Ontology BP GO:1903008 0.0264618689473612 0.0795226262282189 2490 2388.27272727273 2486 0.00243505641978258 169 1.0029453671839 1.18536382612266 1 4.18584756978586 2486 3268 2662 4174 2217 169 2395 2039 3131 2836 894 2497 M16885 GO_LACTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATION.html The secretion of milk by the mammary gland. 23/88 Gene Ontology BP GO:0007595 0.342045084435866 0.463412701206806 4345 2883.63636363636 2486 0.0373412204615047 800 1.12262262161733 -1.03069309216194 -1 1.42340727652591 4345 800 1910 1502 2079 4577 4451 4560 2486 1299 3711 2498 M11627 GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. 14/44 Gene Ontology BP GO:0045746 0.139538803633369 0.239626814388005 2065 2593.54545454545 2487 0.013569525165898 999 1.70820157422404 1.70820157422404 1 4.02312333870952 2064 3572 999 3719 3457 2421 1379 2779 3638 2014 2487 2499 M12608 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. 11/24 Gene Ontology BP GO:0048009 0.0226788098573055 0.0717775829362436 1930 2375.72727272727 2487 0.00208327510394592 619 0.492936313213931 0.505446222081037 1 2.14056445066813 1928 969 2064 1364 619 3485 3120 3279 2487 3537 3281 2500 M14571 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 38/72 Gene Ontology BP GO:0051881 0.0839184282471183 0.158445571591463 3790 2719.45454545455 2489 0.00793650793650794 861 1.70496045265207 1.70496045265207 1 5.17817364311551 3788 2450 2326 2489 1762 2532 4576 2893 861 1997 4240 2501 M11647 GO_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CONTRACTION.html A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. 22/55 Gene Ontology BP GO:0003009 0.164845556299855 0.263106881368246 3445 2680.09090909091 2490 0.0162428755640356 1044 1.98725977860331 -3.11553755502548 -1 4.37412169529693 3443 3241 1044 3211 3728 1662 3578 2336 2490 2354 2394 2502 M15548 GO_CELL_VOLUME_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_VOLUME_HOMEOSTASIS.html Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. 19/45 Gene Ontology BP GO:0006884 0.144362704171259 0.246132854186195 1890 2537.81818181818 2493 0.0140735478628815 1041 0.852246096011289 0.852246096011289 1 1.96955716124686 1890 2709 1398 3154 4149 2493 1757 1041 3963 4301 1061 2503 M15559 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 27/54 Gene Ontology BP GO:1901030 0.013642232691873 0.050958074326924 2495 2667.09090909091 2493 0.00124796092322019 468 1.39934214282505 -0.554099100968402 -1 6.86685881586424 3754 1279 2491 1883 468 3820 4082 2493 2405 2499 4164 2504 M10923 GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. 15/56 Gene Ontology BP GO:0045762 0.366111959603643 0.486229355961017 3795 2479.81818181818 2494 0.0405968464922007 1173 0.936519733884973 -1.01405746558881 -1 1.11324003925883 3793 1173 1259 1463 3253 1906 3987 3018 2494 2060 2872 2505 M11076 GO_MACROMOLECULE_DEACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_DEACYLATION.html The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. 35/70 Gene Ontology BP GO:0098732 0.123138785643997 0.216319856884251 2495 2505.27272727273 2494 0.0118749791936559 422 0.84157669908996 -0.84157669908996 -1 2.12402501165608 2494 2416 3287 2662 4286 422 2375 3577 2115 3159 765 2506 M12213 GO_RESPONSE_TO_GLUCAGON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GLUCAGON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 27/61 Gene Ontology BP GO:0033762 0.290163764461248 0.408623099300447 3685 2878.90909090909 2494 0.0306760930136106 632 1.46693471565438 1.46693471565438 1 2.16424765762639 3682 632 1194 1348 2203 4570 4544 4593 2106 2494 4302 2507 M14299 GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. 7/22 Gene Ontology BP GO:0006577 0.245837472025903 0.358599868870961 1290 2638.45454545455 2495 0.0278204195003092 963 0.313470148448192 0.363892608177331 1 0.529960814819678 1289 3726 4221 3880 2083 1349 1032 2495 4011 3974 963 2508 M13434 GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. 15/26 Gene Ontology BP GO:0001836 0.0214585649652253 0.0689018790688389 3940 2559 2496 0.00197007027544699 227 2.24458518468169 2.24458518468169 1 9.89835629304827 3939 1970 2496 2127 608 3325 4293 3130 227 2074 3960 2509 M11264 GO_CAMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 8/17 Gene Ontology BP GO:0006171 0.196986322643055 0.304463214391379 2055 2291.63636363636 2497 0.021699457744771 574 0.544793320385514 0.616391923685073 1 1.06802162204053 2055 574 3719 1240 1757 2628 1171 2531 3831 3205 2497 2510 M11543 GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 14/32 Gene Ontology BP GO:0046131 0.222273991830172 0.333554668412246 1275 2235 2497 0.0225936696097171 740 1.0296882537552 -1.0296882537552 -1 1.86371401925281 1274 3393 2667 3522 2497 795 740 2566 4118 2011 1002 2511 M13198 GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 14/28 Gene Ontology BP GO:0009218 0.222273991830172 0.333554668412246 1275 2245.45454545455 2498 0.0225936696097171 741 1.0296882537552 -1.0296882537552 -1 1.86371401925281 1275 3394 2668 3523 2498 796 741 2660 4119 2023 1003 2512 M10868 GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 10/20 Gene Ontology BP GO:0090153 0.152161291450459 0.254828813917873 2445 2385.81818181818 2499 0.0148938692681701 429 0.590722687291972 -0.372640598258536 -1 1.33136022323329 2441 429 1419 1608 3477 4632 2836 1064 2499 3107 2732 2513 M11376 GO_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_CONTRACTION.html Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. 110/333 Gene Ontology BP GO:0008016 0.0038965649067947 0.0210859567159065 1870 2425.09090909091 2500 0.00035486213920808 472 1.30557431075971 1.33376571234596 1 8.30585939257232 1870 2912 472 2500 3064 3959 2429 3403 2099 481 3487 2514 M11494 GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. 10/20 Gene Ontology BP GO:1905038 0.160407142315517 0.258740097879113 2445 2404.72727272727 2500 0.0157687325274776 430 0.590722687291972 -0.372640598258536 -1 1.31652704530535 2442 430 1420 1609 3478 4633 2837 1100 2500 3270 2733 2515 M11845 GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 75/171 Gene Ontology BP GO:0035967 0.00182183378944925 0.0120667250847545 1780 2116 2501 0.000165758564802474 32 0.859189599570179 0.968763228229394 1 6.25659154737956 1780 2702 3396 2501 3106 32 1404 2010 3297 2843 205 2516 M15508 GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. 15/31 Gene Ontology BP GO:0006760 0.0839184282471183 0.158445571591463 3930 2685.27272727273 2501 0.00793650793650794 269 0.964916235402726 -0.810865129405406 -1 2.93056874725372 3929 1738 1675 1890 4040 2501 4127 3480 269 2085 3804 2517 M16818 GO_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_CIRCULATION.html Any process that modulates the frequency, rate or extent of blood circulation. 141/435 Gene Ontology BP GO:1903522 0.00202578730371968 0.0130999031353349 1515 2238.54545454545 2502 0.00018433228018885 424 1.30557431075971 1.33376571234596 1 9.33033660602057 1513 3037 424 2502 2846 3443 1986 2786 2125 803 3159 2518 M16935 GO_ACTIVATION_OF_MAPKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). 27/76 Gene Ontology BP GO:0000186 0.0804366188363237 0.158445571591463 1160 2196.09090909091 2503 0.00759431700266861 825 1.21455215107271 1.21455215107271 1 3.68874358757377 1159 3563 3048 3390 3501 1314 1068 825 2754 2503 1032 2519 M15517 GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA.html Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. 13/32 Gene Ontology BP GO:0060330 0.534840098144212 0.647019951975919 2130 2700.27272727273 2504 0.0672139885287663 1462 0.340699588689645 -0.305633351726807 -1 0.244528665795959 2129 2504 2901 2416 2988 1462 1514 4608 3401 4295 1485 2520 M10408 GO_AXO_DENDRITIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXO_DENDRITIC_TRANSPORT.html The directed movement of organelles or molecules along microtubules in neuron projections. 22/46 Gene Ontology BP GO:0008088 0.184522315408928 0.28853563500107 2505 2395.45454545455 2505 0.018372869980262 957 0.802844411190204 -0.802844411190204 -1 1.64502285527096 2503 3595 3234 3430 2505 1015 1956 1158 2979 3018 957 2521 M12220 GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. 6/20 Gene Ontology BP GO:1902991 0.0132621366619729 0.0499400653053853 3940 2398.27272727273 2505 0.00133419558331436 485 0.743128926420273 -0.743128926420273 -1 3.67140717663985 3940 576 3871 612 485 2325 3548 2505 2183 3438 2898 2522 M10519 GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 13/54 Gene Ontology BP GO:0030800 0.301008284063874 0.415823107083775 3830 2593.27272727273 2507 0.0320317920620166 868 1.26417939172274 -1.01405746558881 -1 1.82871094306845 3829 1392 1228 1662 3304 4068 3778 1398 2507 868 4492 2523 M12350 GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. 17/72 Gene Ontology BP GO:0001754 0.232850105696956 0.342669743502683 2930 2386.63636363636 2507 0.0238095238095238 812 1.19951281013891 1.40369885952815 1 2.11778123225603 2929 812 1645 1257 3192 4471 2996 2507 1678 1039 3727 2524 M15725 GO_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_NUCLEATION.html The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. 13/25 Gene Ontology BP GO:0045010 0.161980953911971 0.259247697005612 3730 2702.09090909091 2507 0.015936597003701 1468 0.625059557561618 -0.625059557561618 -1 1.39103316012267 3728 1796 2832 1468 1580 3885 3577 1944 2067 4339 2507 2525 M11455 GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 18/28 Gene Ontology BP GO:0033014 0.225425346327153 0.337730231845338 2510 2556.90909090909 2508 0.02295437640373 1066 0.220703954665274 -0.243857399846151 -1 0.394943180156963 2508 3632 3347 3788 1794 1066 1106 1988 4164 3256 1477 2526 M13576 GO_SKIN_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. 45/111 Gene Ontology BP GO:0098773 0.0181146943173128 0.0617975942066739 1375 2098 2508 0.00166050838298273 638 1.15678433711544 1.18200258610613 1 5.30879731427542 1373 2661 638 2829 2986 2908 2508 2568 1233 1363 2011 2527 M14864 GO_ERROR_PRONE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_PRONE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 8/25 Gene Ontology BP GO:0042276 0.068328903975417 0.152671367255949 2640 2368.45454545455 2509 0.00705255596145834 809 0.839316232100865 -0.839316232100865 -1 2.60047095018722 1273 3220 4307 2639 2509 1466 2142 809 2639 4118 931 2528 M10852 GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT.html The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. 7/16 Gene Ontology BP GO:0099514 0.531097175083329 0.642826950967648 1965 2565.36363636364 2512 0.0729390564773588 1227 0.272933803525158 -0.272225024075346 -1 0.198816735311352 1963 2512 3649 3168 2523 1227 2484 2037 3602 3104 1950 2529 M11001 GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. 12/22 Gene Ontology BP GO:0042219 0.381895152886069 0.503303773729781 3345 2536.09090909091 2512 0.042793476047425 935 0.964916235402726 -0.810865129405406 -1 1.09209524994868 3341 4369 2512 3452 2610 935 1544 2212 3026 1856 2040 2530 M12089 GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM.html The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 12/25 Gene Ontology BP GO:0003159 0.772944651404018 0.851372232402829 1495 2553.72727272727 2512 0.126090377114155 1494 1.19045135446987 1.19045135446987 1 0.315773007134775 1494 1799 1707 1577 4431 3305 3279 2812 3310 1865 2512 2531 M11261 GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT.html The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. 7/16 Gene Ontology BP GO:0048490 0.531097175083329 0.642826950967648 1965 2584.45454545455 2513 0.0729390564773588 1228 0.272933803525158 -0.272225024075346 -1 0.198816735311352 1964 2513 3718 3169 2524 1228 2485 2070 3603 3204 1951 2532 M14639 GO_HEART_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_DEVELOPMENT.html The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. 21/47 Gene Ontology BP GO:0003170 0.0416332817997131 0.108036334310191 2735 2343.27272727273 2513 0.00385842603880865 752 1.24967114279224 -0.791140711360448 -1 4.584304398059 2731 1383 752 1361 3217 3393 2168 2652 2513 2330 3276 2533 M16218 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. 364/1067 Gene Ontology BP GO:0000122 0.029114041756784 0.0843271964296618 2475 2846.27272727273 2513 0.002682419985739 725 1.25011306934902 1.36472733232458 1 5.09652177846591 2473 3796 2075 3994 725 4533 2110 2269 2695 2513 4126 2534 M16483 GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. 36/79 Gene Ontology BP GO:0006521 0.184919924354895 0.288890716278526 1190 2536.90909090909 2513 0.0184163905131087 1053 0.261653625242453 -0.269248553693855 -1 0.535596043754643 1186 2775 3451 3798 1671 1053 2513 2423 2907 4514 1615 2535 M11922 GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. 7/16 Gene Ontology BP GO:0099517 0.531097175083329 0.642826950967648 1965 2609.27272727273 2514 0.0729390564773588 1229 0.272933803525158 -0.272225024075346 -1 0.198816735311352 1965 2514 3823 3170 2525 1229 2486 2064 3604 3370 1952 2536 M14850 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 443/1011 Gene Ontology BP GO:0080135 0.0173415721880107 0.0600971175320337 3160 2613.72727272727 2514 0.00158907231786083 545 1.19140127739564 1.26423086961624 1 5.52246549374486 3160 1673 2467 2499 545 2514 2503 3659 2673 2862 4196 2537 M10673 GO_ENERGY_RESERVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_RESERVE_METABOLIC_PROCESS.html The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. 28/89 Gene Ontology BP GO:0006112 0.0839184282471183 0.158445571591463 2815 2647.45454545455 2517 0.00793650793650794 789 1.70956702222945 1.70956702222945 1 5.19216435893213 2813 2292 2492 1957 2241 4193 3075 3013 789 2517 3740 2538 M11224 GO_CEREBELLAR_CORTEX_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 21/57 Gene Ontology BP GO:0021696 0.232850105696956 0.342669743502683 3810 2369.54545454545 2518 0.0238095238095238 664 1.28836660323947 -1.27502197741866 -1 2.27465566816727 3808 2779 1296 2087 3492 2660 2705 2518 1833 664 2223 2539 M13384 GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. 42/93 Gene Ontology BP GO:0046823 0.0367016772622526 0.09861451824574 2855 2574.54545454545 2518 0.00339351355341734 597 1.18774485983252 1.36870232873206 1 4.53580006332414 2853 2249 2333 1989 3777 3670 3831 597 2518 1276 3227 2540 M14887 GO_INTERACTION_WITH_SYMBIONT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_SYMBIONT.html An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 24/80 Gene Ontology BP GO:0051702 0.0048513135091054 0.0246440356923155 1840 2393 2518 0.000442004044550226 252 1.35593454827845 1.35593454827845 1 8.27770271557896 1837 1690 1833 2518 252 4438 2581 2974 2968 2418 2814 2541 M11621 GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). 28/58 Gene Ontology BP GO:0007223 0.557443745451391 0.666249592815201 2185 2521.45454545455 2519 0.0714285714285714 1431 1.46584243959724 1.46584243959724 1 0.981300696194251 2184 1431 1826 2915 3953 3444 2072 1840 2764 2519 2788 2542 M12493 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. 14/27 Gene Ontology BP GO:0050687 0.127295774108938 0.222026400896994 2520 2166.81818181818 2520 0.0123017599682956 435 1.14505098292374 1.14505098292374 1 2.84080242035696 2520 2853 2856 2771 2710 435 711 4189 1431 2018 1341 2543 M10216 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 51/133 Gene Ontology BP GO:0034763 0.0839184282471183 0.158445571591463 4160 2797.72727272727 2521 0.00793650793650794 1083 1.37068921051971 1.34463734700163 1 4.1629509539159 4158 2156 2521 1917 3293 2381 3906 4453 1083 1554 3353 2544 M11113 GO_FERRIC_IRON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERRIC_IRON_TRANSPORT.html The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/44 Gene Ontology BP GO:0015682 0.580955969400432 0.687755881164254 1705 2397 2521 0.0760255355524672 1304 0.801505046067566 -0.801505046067566 -1 0.494586634473956 1701 2261 2602 2768 2521 1304 2817 2435 3126 3170 1662 2545 M11456 GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. 95/214 Gene Ontology BP GO:1901293 0.0266245955366159 0.0797535465009727 1500 2284.09090909091 2522 0.00245021599553807 583 0.869370719743103 0.869370719743103 1 3.62421080124357 1496 2913 2965 3684 686 583 1880 2522 4067 2876 1453 2546 M11465 GO_NEURAL_RETINA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_RETINA_DEVELOPMENT.html The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. 23/87 Gene Ontology BP GO:0003407 0.0777898064529497 0.158445571591463 4240 2734.90909090909 2522 0.00733497640207619 1189 1.05398004901363 -0.792904243146179 -1 3.20106645380974 4237 2258 2156 2522 1189 3687 2675 3194 1789 2387 3990 2547 M16469 GO_TRIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 19/44 Gene Ontology BP GO:0072512 0.580955969400432 0.687755881164254 1705 2517.54545454545 2522 0.0760255355524672 1305 0.801505046067566 -0.801505046067566 -1 0.494586634473956 1702 2262 2603 2769 2522 1305 2818 2409 3127 4513 1663 2548 M13293 GO_ELECTRON_TRANSPORT_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_TRANSPORT_CHAIN.html A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 52/110 Gene Ontology BP GO:0022900 0.161569848631282 0.258857421392354 885 2553.36363636364 2523 0.0158927204266089 520 0.564322045552235 -0.564322045552235 -1 1.2572669405538 883 3974 3471 4095 2405 520 1210 2523 4061 3698 1247 2549 M12980 GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a symbiont organism effects a change in the structure or processes of its host organism. 32/81 Gene Ontology BP GO:0044003 0.193940424099047 0.301058304611126 4545 2652.36363636364 2525 0.0194089569629415 1237 1.84601786585865 1.84601786585865 1 3.6531878055562 4543 1524 1449 2525 1696 1237 3931 3772 2818 1745 3936 2550 M15353 GO_SPERMATID_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_DIFFERENTIATION.html The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 70/283 Gene Ontology BP GO:0048515 0.174759347916122 0.275520425254517 2530 2857.45454545455 2526 0.017310265224917 590 0.253260019528954 -0.280826688353602 -1 0.538198647000033 2526 4442 3354 4406 1633 590 2522 2348 4168 4251 1192 2551 M10087 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 61/165 Gene Ontology BP GO:0051928 0.0257376167591352 0.0784268537777523 3160 2533.90909090909 2527 0.00236761316366145 672 1.3675915169234 1.57574571375777 1 5.73899976620825 3157 2838 1222 2024 672 3111 3532 2369 2082 2527 4339 2552 M14004 GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. 52/125 Gene Ontology BP GO:0060333 0.280807021100203 0.398346165282078 2710 2677.36363636364 2527 0.0295214317686724 1415 2.01277540612347 2.01277540612347 1 3.05407332827645 2709 2879 1415 3028 1937 4183 2233 2471 2527 2377 3692 2553 M14563 GO_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. 396/787 Gene Ontology BP GO:0007005 0.171838702780796 0.272581857537149 1575 2560.27272727273 2527 0.0169946017941269 616 1.13045660135559 1.38602327767357 1 2.42229716323671 1573 4314 3487 4472 1614 616 2527 2198 3058 2899 1405 2554 M16946 GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 14/50 Gene Ontology BP GO:0010907 0.39862791396482 0.519749902987548 1605 2532.18181818182 2528 0.0451786638690318 1551 0.405616188139476 0.421789260034903 1 0.437577633701042 1604 1602 2528 2848 3448 2656 1959 1551 2846 4636 2176 2555 M16122 GO_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. 70/195 Gene Ontology BP GO:0055001 0.00384353003837896 0.0208719414832673 4155 2606.09090909091 2529 0.000350023762034852 470 1.83034439351975 -1.57303298172666 -1 11.6751459628223 4152 1573 470 1954 2590 2529 4584 3306 2014 1445 4050 2556 M16497 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 367/874 Gene Ontology BP GO:0031400 0.12191912765463 0.214420647613806 3130 2491.54545454545 2529 0.0117501109532766 1419 1.26345734138904 1.32100062002028 1 3.20716147727666 2610 3127 2397 2566 1419 1928 3130 1706 2280 2529 3715 2557 M11235 GO_CELLULAR_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENTATION.html The deposition or aggregation of coloring matter in a cell. 29/56 Gene Ontology BP GO:0033059 0.0586863076716993 0.137200667935398 4130 2663.72727272727 2531 0.00548298909257472 507 1.59317129651972 1.59317129651972 1 5.21676407855927 4129 1322 2976 2035 1044 2398 4528 4167 507 2531 3664 2558 M13685 GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of epidermis development. 18/47 Gene Ontology BP GO:0045684 0.0330644057190611 0.0924807444298798 2535 2631.09090909091 2531 0.00305200489747848 566 1.33403223803043 -1.33403223803043 -1 5.23567331200877 2531 2426 1474 2528 3697 3478 3792 566 3102 2201 3147 2559 M16823 GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION.html A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. 13/30 Gene Ontology BP GO:0034629 0.0508403699644745 0.124289071278 1555 2622.36363636364 2531 0.00473224799455617 360 0.323344683253555 0.37815849683031 1 1.11145931651803 1551 4338 2531 4180 3325 1929 360 1166 3582 4601 1283 2560 M11962 GO_RESPONSE_TO_NERVE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NERVE_GROWTH_FACTOR.html A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. 27/59 Gene Ontology BP GO:1990089 0.00131457740902801 0.00955177294228017 4030 2667.81818181818 2532 0.000119578506638916 109 1.09543975665388 -0.493393016758395 -1 8.39902823351236 4030 1481 2532 2102 109 4115 3471 2741 1964 2493 4308 2561 M12478 GO_NCRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_TRANSCRIPTION.html The transcription of non (protein) coding RNA from a DNA template. 46/106 Gene Ontology BP GO:0098781 0.0987444940631015 0.180467567090794 1445 2388.63636363636 2532 0.00940697326552336 444 0.234621468282013 -0.267491588088386 -1 0.662239145804043 1445 3317 3442 3282 2532 444 2251 892 4031 3500 1139 2562 M15710 GO_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLATION.html The covalent attachment and further modification of carbohydrate residues to a substrate molecule. 126/292 Gene Ontology BP GO:0070085 0.0350129603929157 0.0957392079530669 4355 2602.36363636364 2532 0.00323481197547437 793 1.05051284149164 -1.0180746495426 -1 4.06297821400555 4355 1356 2860 2111 793 1096 4361 4442 1867 2853 2532 2563 M16429 GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. 72/262 Gene Ontology BP GO:0098742 4.95200162009138e-05 0.00083607794625761 2370 2293.90909090909 2532 4.5019209897229e-06 227 1.78415217055621 -1.46243506003998 -1 20.8436090971463 2367 2555 227 1309 3107 3379 2532 4224 1008 691 3834 2564 M11529 GO_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 12/54 Gene Ontology BP GO:0006584 0.0948565077816501 0.174977658176481 4205 2449.81818181818 2533 0.00901924338807267 818 1.48369148420437 -1.03069309216194 -1 4.26340604875158 4202 2533 958 1739 1287 3806 3164 1187 2665 818 4589 2565 M15740 GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. 12/54 Gene Ontology BP GO:0009712 0.0948565077816501 0.174977658176481 4205 2453.90909090909 2534 0.00901924338807267 825 1.48369148420437 -1.03069309216194 -1 4.26340604875158 4203 2534 959 1740 1288 3807 3165 1216 2666 825 4590 2566 M13899 GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. 72/173 Gene Ontology BP GO:0006367 0.021035065766573 0.0681072596612261 2330 2257.72727272727 2536 0.00193081131157383 147 1.19851050335346 1.19851050335346 1 5.30820821858855 2327 3311 3330 3280 1618 147 1911 3195 2536 2634 546 2567 M14883 GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. 14/44 Gene Ontology BP GO:0038083 0.254605345125989 0.368495204931411 3240 2467.45454545455 2536 0.0263592276443347 704 0.341594719430449 -0.365352909040854 -1 0.562180477235413 3239 2305 2895 2536 3836 704 825 1677 3901 4123 1101 2568 M15857 GO_2_OXOGLUTARATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_OXOGLUTARATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. 11/25 Gene Ontology BP GO:0006103 0.247908354652403 0.36094026047385 4260 2712.81818181818 2536 0.0255672145515606 1679 1.23889395501682 -1.23889395501682 -1 2.08122056521264 4256 2536 2250 2298 1856 3005 1679 3425 3094 1816 3626 2569 M11631 GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that activates or increases the rate of neuroblast proliferation. 11/33 Gene Ontology BP GO:0002052 0.232850105696956 0.342669743502683 2565 2337.72727272727 2537 0.0238095238095238 759 0.353003006213062 -0.378923065095292 -1 0.6232389808756 2562 2537 2714 2288 4371 759 1312 2689 1887 3301 1295 2570 M15405 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. 10/38 Gene Ontology BP GO:1901984 0.00564156466219371 0.0272001918240554 1235 2259.54545454545 2537 0.00051418943149364 112 0.218769779759666 0.270070325028261 1 1.29995305016437 1235 3690 3037 3797 2537 337 112 1002 4392 4263 453 2571 M16674 GO_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_ASSEMBLY.html The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 6/22 Gene Ontology BP GO:0046847 0.396861295560985 0.518319829898637 1545 2698.90909090909 2537 0.0493038834674799 1544 0.98466997341672 0.98466997341672 1 1.06673170960413 1544 3446 4602 1925 2685 2537 1773 1602 3045 4560 1969 2572 M12959 GO_REGULATION_OF_CHEMOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_SECRETION.html Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell. 5/20 Gene Ontology BP GO:0090196 0.381571216861435 0.503019636538229 1900 2582.45454545455 2538 0.0469208486318936 1058 0.452806365419475 0.452621312132765 1 0.512909203983661 1897 3030 3986 3117 2538 1380 1058 1769 4052 3615 1965 2573 M11523 GO_POSITIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of STAT cascade. 35/133 Gene Ontology BP GO:1904894 0.361282698450554 0.481330148896965 2665 2514.18181818182 2539 0.0399346645721927 1298 0.943194700221817 -0.671837249370926 -1 1.13692072676435 2661 1583 1298 1722 2956 4540 2530 1500 2539 2614 3713 2574 M13800 GO_MAINTENANCE_OF_CELL_NUMBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_NUMBER.html Any process by which the numbers of cells of a particular type in a tissue are maintained. 94/209 Gene Ontology BP GO:0098727 0.0490680482933546 0.12073288194279 4125 2462.36363636364 2539 0.0045634441980266 509 1.17331399418419 -1.13815648202073 -1 4.08927838390534 4125 3493 1949 2539 961 509 4360 3054 2874 2090 1132 2575 M15878 GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. 35/133 Gene Ontology BP GO:0046427 0.327260151110139 0.447034092852125 2665 2511.36363636364 2540 0.0353944836689728 1299 0.943194700221817 -0.671837249370926 -1 1.25185415205461 2662 1584 1299 1723 2957 4541 2531 1452 2540 2622 3714 2576 M15159 GO_RESPONSE_TO_DEXAMETHASONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DEXAMETHASONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 16/45 Gene Ontology BP GO:0071548 0.00456965757429386 0.0236005785511083 2545 2458 2541 0.000416288816518948 489 0.858982002181133 0.858982002181133 1 5.30517232011775 2541 1652 489 1670 609 4277 1996 2873 3211 4196 3524 2577 M11249 GO_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 29/78 Gene Ontology BP GO:0006801 0.214924028460924 0.323675726287405 3210 2733.72727272727 2542 0.0217575227174951 1230 1.16356710097134 -1.03069309216194 -1 2.16370038591632 3208 2160 2361 2386 4309 3378 2845 1230 2542 1563 4089 2578 M11340 GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. 12/29 Gene Ontology BP GO:0095500 0.295739732747333 0.413174493778819 2765 2640.36363636364 2543 0.0313707878339038 1326 0.650112755713168 -0.650112755713168 -1 0.947275111915151 2765 2124 2107 2543 1975 3662 1326 2461 3311 3230 3540 2579 M12749 GO_POSITIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 139/394 Gene Ontology BP GO:0043270 0.10240740122831 0.186096893895515 2545 2586.54545454545 2543 0.00977365071728253 1319 1.27027035642704 1.39655478586361 1 3.52112487894326 2543 2954 1393 2283 1319 3067 3963 1888 2269 2632 4141 2580 M11878 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION.html Any signal transduction that is involved in cellular response to ammonium ion. 12/29 Gene Ontology BP GO:1903831 0.295739732747333 0.413174493778819 2770 2655.45454545455 2544 0.0313707878339038 1327 0.650112755713168 -0.650112755713168 -1 0.947275111915151 2766 2125 2108 2544 1976 3663 1327 2487 3312 3361 3541 2581 M12189 GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 12/29 Gene Ontology BP GO:1905145 0.295739732747333 0.413174493778819 2770 2662.18181818182 2545 0.0313707878339038 1328 0.650112755713168 -0.650112755713168 -1 0.947275111915151 2767 2126 2109 2545 1977 3664 1328 2482 3313 3431 3542 2582 M13410 GO_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 26/73 Gene Ontology BP GO:0042116 0.514011397665828 0.627050688219243 2625 2539 2545 0.0634920634920635 1185 1.14309325609016 -0.989745402399581 -1 0.879502274475749 2621 3093 2519 2196 4170 1185 2698 2545 2627 2470 1805 2583 M13242 GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. 12/29 Gene Ontology BP GO:0007213 0.295739732747333 0.413174493778819 2770 2686.63636363636 2546 0.0313707878339038 1329 0.650112755713168 -0.650112755713168 -1 0.947275111915151 2768 2127 2110 2546 1978 3665 1329 2492 3314 3681 3543 2584 M12147 GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. 12/22 Gene Ontology BP GO:0045540 0.466738071388703 0.580826820010117 4175 3039.09090909091 2547 0.0555555555555556 1646 1.33376424024472 -1.33376424024472 -1 1.1945722615497 4175 1659 1646 2230 3988 4085 4456 4500 2547 1866 2278 2585 M12760 GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. 11/16 Gene Ontology BP GO:0070243 0.25277130262625 0.36670372077809 2970 2416 2547 0.0261416852232049 1159 1.46584243959724 1.46584243959724 1 2.42419089055411 2970 2313 1159 2568 2547 3268 1964 2071 2564 1791 3361 2586 M14251 GO_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 12/29 Gene Ontology BP GO:1905144 0.295739732747333 0.413174493778819 2770 2708.63636363636 2547 0.0313707878339038 1330 0.650112755713168 -0.650112755713168 -1 0.947275111915151 2769 2128 2111 2547 1979 3666 1330 2448 3315 3958 3544 2587 M16503 GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. 96/203 Gene Ontology BP GO:2001020 0.0760210353940095 0.158445571591463 2075 2569.72727272727 2547 0.00716204517749028 1174 1.69549056884594 1.69549056884594 1 5.14941244654134 2075 3231 2755 2486 1174 4157 2724 2090 1834 2547 3194 2588 M14366 GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS.html A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. 15/34 Gene Ontology BP GO:0034067 0.0119842391643453 0.0460816150833625 2550 2502.36363636364 2548 0.00109545673950423 438 0.493393016758395 -0.493393016758395 -1 2.5029962213189 2548 2304 3281 2969 438 996 2869 2431 4103 3989 1598 2589 M15706 GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION.html Signal transduction in which the initial step occurs in a postsynapse. 12/29 Gene Ontology BP GO:0098926 0.295739732747333 0.413174493778819 2770 2747.45454545455 2548 0.0313707878339038 1331 0.650112755713168 -0.650112755713168 -1 0.947275111915151 2770 2129 2112 2548 1980 3667 1331 2491 3316 4333 3545 2590 M15077 GO_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_RECOGNITION.html The process in which a cell in an organism interprets its surroundings. 64/345 Gene Ontology BP GO:0008037 0.159606013975509 0.258740097879113 2080 2619.63636363636 2549 0.0156833931357246 1032 1.40314295350662 1.40314295350662 1 3.12714525208644 2077 4122 1032 4287 2627 4140 1810 1537 1911 2549 2724 2591 M13250 GO_POST_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_MORPHOGENESIS.html The process, occurring after embryonic development, by which anatomical structures are generated and organized. 6/17 Gene Ontology BP GO:0009886 0.147859119791321 0.249186894080256 2925 2777.09090909091 2552 0.0158730158730159 1279 1.98021329601685 1.98021329601685 1 4.53605534636845 2924 2545 4038 2552 4351 3651 2267 2427 1279 1321 3193 2592 M14842 GO_THALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THALAMUS_DEVELOPMENT.html The process in which the thalamus changes over time, from its initial formation to its mature state. 4/31 Gene Ontology BP GO:0021794 0.431369017822477 0.550686376065372 1775 2729.45454545455 2552 0.0548884907771022 1160 0.43690561855693 0.459171660517881 1 0.42968976789804 1772 1559 4301 1918 4514 2945 1160 2552 2934 4109 2260 2593 M11009 GO_SERTOLI_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. 14/21 Gene Ontology BP GO:0060009 0.0766298870697362 0.158445571591463 2905 2579.27272727273 2553 0.00722153808894679 1180 0.50491279453589 -0.50491279453589 -1 1.53348197634632 2903 1857 2498 2494 1180 2018 3504 2553 3471 3139 2755 2594 M11275 GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper cell differentiation. 9/40 Gene Ontology BP GO:0045622 0.205645890159778 0.313877011180753 1450 2418.63636363636 2553 0.0227595957561436 993 0.474188916108685 0.492575614187533 1 0.90580394376934 1446 3299 3720 3273 3510 1645 993 1254 2553 3208 1704 2595 M11705 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 93/207 Gene Ontology BP GO:1903828 0.12363720652843 0.217031209796408 2835 2319.27272727273 2556 0.0119260528343705 424 1.14443999311326 -0.920177657494458 -1 2.88221688929655 2833 2553 2556 2964 2760 424 2546 2955 2752 2055 1114 2596 M12330 GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 31/78 Gene Ontology BP GO:0045661 0.107563739381289 0.19372321254745 3875 2715.27272727273 2556 0.0102921410020385 628 1.07272638267715 -1.07272638267715 -1 2.9025189006301 3872 628 1729 1717 1348 3173 4010 4069 2555 2556 4211 2597 M14976 GO_FEMALE_MEIOTIC_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_MEIOTIC_DIVISION.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. 10/32 Gene Ontology BP GO:0007143 0.101669340649442 0.184972863885329 1275 2171.81818181818 2556 0.00969965743825477 382 0.307621434652642 -0.313275445852247 -1 0.855783272027893 1272 2861 2943 2669 2556 382 835 1801 3482 4142 947 2598 M16471 GO_BILE_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 18/68 Gene Ontology BP GO:0008206 0.0481705164859542 0.119283044290286 4270 2738.27272727273 2556 0.00447806834432514 885 0.878659028734964 -0.50491279453589 -1 3.07983527025021 4269 885 1748 1210 952 4377 4392 3345 2556 2215 4172 2599 M10715 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. 56/147 Gene Ontology BP GO:0070664 0.0684101544440486 0.152779387726656 4500 2954.72727272727 2557 0.00642135270458201 840 1.34744748233108 1.34744748233108 1 4.17325349848771 4500 2557 840 2215 1368 3150 4524 4486 2470 2433 3959 2600 M13868 GO_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 23/71 Gene Ontology BP GO:0098900 0.311583192427308 0.428773195743922 2745 2569.90909090909 2557 0.0333723270975111 1083 1.13975148755868 -1.13975148755868 -1 1.59109642305206 2742 3350 1641 3129 4548 1083 2557 1418 2962 2394 2445 2601 M13335 GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. 51/122 Gene Ontology BP GO:0031032 0.0338089450312703 0.0934933505499497 4130 2622.36363636364 2558 0.00312181559159318 732 2.2702248085889 -2.07333958077616 -1 8.86919100212645 4127 2410 732 2558 2678 1684 3632 3347 2030 2347 3301 2602 M13117 GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 31/45 Gene Ontology BP GO:0010837 0.593656995889687 0.700292030466417 2555 2816 2559 0.0786072327154524 1797 1.0923235667937 1.0923235667937 1 0.64151568879939 1797 3047 2332 3488 2551 2778 1971 4379 3519 2559 2555 2603 M11754 GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. 36/91 Gene Ontology BP GO:1904063 0.0839184282471183 0.158445571591463 4070 2764.18181818182 2560 0.00793650793650794 968 1.37068921051971 1.34463734700163 1 4.1629509539159 4068 2560 2163 2188 2868 2157 4331 4616 968 1077 3410 2604 M13649 GO_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REGENERATION.html The regrowth of lost or destroyed tissues. 31/80 Gene Ontology BP GO:0042246 0.228585909450314 0.341701345002513 3120 2573.63636363636 2560 0.0233174796974382 950 1.21455215107271 1.21455215107271 1 2.15000001886313 3120 950 1696 2015 1807 2802 4559 2870 1883 2560 4048 2605 M14884 GO_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ASSEMBLY.html A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. 102/211 Gene Ontology BP GO:0034329 0.000273811677751045 0.00303414706395728 2015 2607.09090909091 2560 2.48950692955919e-05 305 1.54493257103047 1.8852765158377 1 14.7661123604281 2015 3084 305 2777 4142 4268 2560 1799 2417 2221 3090 2606 M12923 GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rac protein signal transduction. 10/20 Gene Ontology BP GO:0035020 0.329816000251818 0.450128068538857 2565 2748.36363636364 2561 0.0357282144517618 1099 1.24287224182961 -1.24287224182961 -1 1.63546910521161 2561 2935 2137 3366 2162 2390 4107 3637 4144 1694 1099 2607 M10848 GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. 30/98 Gene Ontology BP GO:2000737 0.0839184282471183 0.158445571591463 4625 2762.63636363636 2562 0.00793650793650794 769 1.82551842389692 1.82551842389692 1 5.54432296242545 4623 2562 1943 2315 3877 2895 4336 1507 769 1644 3918 2608 M12329 GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 10/22 Gene Ontology BP GO:0098911 0.0992219917278089 0.181159145730325 1660 2240.09090909091 2563 0.00945469657066793 377 1.13975148755868 -1.13975148755868 -1 3.20985954979688 1660 3820 2660 2563 3366 377 1205 3201 3060 1690 1039 2609 M12736 GO_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION.html The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 64/184 Gene Ontology BP GO:0042113 0.35943518917414 0.479556776820555 2360 2744.27272727273 2563 0.0396825396825397 1204 1.54593953427487 1.54593953427487 1 1.8728722146566 2357 4033 2563 3663 2938 3920 2529 1872 2299 2809 1204 2610 M15044 GO_RESPONSE_TO_THYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_THYROID_HORMONE.html A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 16/42 Gene Ontology BP GO:0097066 0.0311998630951213 0.0887084901106234 1540 2407.09090909091 2563 0.00287739284060623 717 0.559156160931158 0.634959798782742 1 2.23290608230874 1536 3355 717 2651 2109 1981 1074 3048 3278 4166 2563 2611 M15655 GO_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_LOCALIZATION.html Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. 31/54 Gene Ontology BP GO:0051646 0.0264982686804279 0.0795805054872102 3810 2437.18181818182 2563 0.00243844721144787 505 1.67949129323189 1.67949129323189 1 7.00743475691696 3810 3092 2398 2963 2989 969 3862 505 2029 2563 1629 2612 M10442 GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS.html The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 22/50 Gene Ontology BP GO:0050951 0.161385165508919 0.258740097879113 3265 2616.36363636364 2564 0.0158730158730159 1437 1.31394404283802 1.31394404283802 1 2.92835014763378 3265 2564 1499 2575 2301 3758 2406 2778 1437 2352 3845 2613 M12094 GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 26/59 Gene Ontology BP GO:0051281 0.00617616264081049 0.0290830863501857 4135 2696.27272727273 2564 0.000563051793061909 280 1.02153487267164 -0.743128926420273 -1 5.95735225249082 4132 3210 1827 2872 280 2564 4285 2101 2085 2465 3838 2614 M11658 GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. 11/35 Gene Ontology BP GO:0046471 0.232850105696956 0.342669743502683 3785 3008.72727272727 2566 0.0238095238095238 1782 1.27675999939789 -1.27675999939789 -1 2.25416380882219 3784 3218 2429 2433 4552 2566 4315 3947 1807 1782 2263 2615 M10492 GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that stops or reduces the activity of a transporter. 43/102 Gene Ontology BP GO:0032410 0.232850105696956 0.342669743502683 3605 2943.45454545455 2567 0.0238095238095238 1876 1.34463734700163 1.34463734700163 1 2.37400360681975 3604 2288 2567 2745 3669 3965 2450 2512 1876 2133 4569 2616 M13005 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 105/299 Gene Ontology BP GO:0051924 0.0839184282471183 0.158445571591463 2795 2512.90909090909 2569 0.00793650793650794 1015 1.42332387566238 1.53668970053607 1 4.32280887633362 2791 3308 1015 2027 1389 3369 3819 2569 1123 2270 3962 2617 M16046 GO_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORYLATION.html The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. 586/1444 Gene Ontology BP GO:0016310 0.0319946154161319 0.0902504463494716 4630 2521.90909090909 2569 0.00324648165843039 198 1.28323401506384 1.46929083867709 1 5.08794718218075 4629 1300 4501 2796 868 198 4423 4445 1220 2569 792 2618 M16672 GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. 13/37 Gene Ontology BP GO:0032897 0.466738071388703 0.580826820010117 2895 2686.09090909091 2569 0.0555555555555556 1176 0.365088492730876 -0.373995084985214 -1 0.326987763726428 2536 1176 2891 1742 2895 2310 3732 3754 2569 4559 1383 2619 M13200 GO_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of B cell differentiation. 16/36 Gene Ontology BP GO:0045577 0.173004582253536 0.274047850792458 2180 2506.45454545455 2572 0.0171204885409644 1174 0.849254971022537 0.849254971022537 1 1.81224026435984 2177 3011 2535 2882 1621 1174 2830 2572 3378 3668 1723 2620 M10210 GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 10/40 Gene Ontology BP GO:0045745 0.605567206330198 0.708580780995743 4585 2667.27272727273 2573 0.0810957204415058 1609 1.11882204112119 1.11882204112119 1 0.635375844594874 4585 1609 1863 1965 2573 2639 2716 2337 3253 1673 4127 2621 M13874 GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. 10/35 Gene Ontology BP GO:0034142 0.466738071388703 0.580826820010117 3865 2906.36363636364 2573 0.0555555555555556 1894 0.424272754478249 -0.352427615011625 -1 0.379995540723965 3813 2573 1894 2452 3861 2394 3265 2508 2521 3861 2828 2622 M13891 GO_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 32/61 Gene Ontology BP GO:0071616 0.0577799537605813 0.135971781708251 3180 2407.18181818182 2574 0.0053959743243287 625 0.940767540772448 -0.940767540772448 -1 3.09445227779139 3177 625 2574 2540 1033 1138 3563 3529 2965 3865 1470 2623 M14794 GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. 21/54 Gene Ontology BP GO:0048169 0.35943518917414 0.479556776820555 2175 2571.36363636364 2575 0.0396825396825397 1227 1.31394404283802 1.31394404283802 1 1.59181470868983 2172 3178 2624 3201 2575 3516 1227 2718 2315 2332 2427 2624 M15448 GO_THIOESTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 32/61 Gene Ontology BP GO:0035384 0.0577799537605813 0.135971781708251 3180 2442.36363636364 2575 0.0053959743243287 626 0.940767540772448 -0.940767540772448 -1 3.09445227779139 3178 626 2575 2541 1034 1139 3564 3496 2966 4276 1471 2625 M14544 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. 96/288 Gene Ontology BP GO:0002703 0.117243909440036 0.208090012052786 1510 2530.90909090909 2578 0.011272919477515 1301 0.976817557927649 1.13277385368578 1 2.52781361109159 1506 3906 2315 3855 1390 2578 1301 2088 3136 2769 2996 2626 M15792 GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that activates or increases the activity of a monooxygenase. 19/35 Gene Ontology BP GO:0032770 0.466738071388703 0.580826820010117 2645 2829.72727272727 2580 0.0555555555555556 1939 0.41280453707584 0.443795465144976 1 0.36972414943381 2643 1939 2192 2890 2580 3749 2488 2286 2510 4354 3496 2627 M11283 GO_RESPONSE_TO_FUNGICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. 7/20 Gene Ontology BP GO:0060992 0.173300333714315 0.274047850792458 2345 2306.81818181818 2581 0.0188514277023046 680 0.316297287725036 -0.353489846880361 -1 0.674952399205454 2344 2581 3723 3230 3026 750 680 1361 3605 3211 864 2628 M16624 GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of cation transmembrane transport. 117/316 Gene Ontology BP GO:1904062 0.205963858058614 0.314259018391766 3045 2808.09090909091 2581 0.020747768122453 1581 1.26718752800403 -1.10189111717827 -1 2.41806287537991 3043 3339 1581 2503 1740 4077 3250 2231 2581 2004 4540 2629 M11152 GO_RESPONSE_TO_MORPHINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MORPHINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. 16/40 Gene Ontology BP GO:0043278 0.0144888609648104 0.0529905048283087 4580 2737.63636363636 2582 0.00132592468639112 479 0.821809750370218 -0.989745402399581 -1 3.97980487761459 4579 2459 2409 2265 479 2812 2582 3428 2575 3181 3345 2630 M11590 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 6/23 Gene Ontology BP GO:0010744 0.231939821759413 0.342669743502683 2585 2612.81818181818 2582 0.0260435795275426 1527 0.597004167177931 -0.769133773796609 -1 1.05403144512899 2582 1750 3774 1527 1867 2012 2608 3629 3494 3296 2202 2631 M12250 GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 140/301 Gene Ontology BP GO:0010821 0.00333824650658403 0.0189248822100973 2760 2140.45454545455 2582 0.000303938427076228 144 1.06742143940097 1.33168187382829 1 6.98103901807379 2757 2443 3344 3134 192 144 1717 3723 2582 2785 724 2632 M14248 GO_RESPONSE_TO_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TEMPERATURE_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. 100/246 Gene Ontology BP GO:0009266 0.0386617039090299 0.102224539436006 4025 2553.45454545455 2582 0.00357802962278105 841 1.09726030963657 1.09726030963657 1 4.12522075166289 4021 1953 1083 2706 841 1722 3859 3892 1627 2582 3802 2633 M10903 GO_PHOSPHOLIPID_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 19/34 Gene Ontology BP GO:0046839 0.042479598102171 0.109330805980255 2585 2451.45454545455 2583 0.00393842857467741 830 0.249035540400121 -0.290544292962567 -1 0.908674374013419 2583 3630 3267 3675 890 830 1670 2538 3488 3115 1280 2634 M16195 GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. 16/40 Gene Ontology BP GO:0014072 0.0144888609648104 0.0529905048283087 4580 2849.18181818182 2583 0.00132592468639112 480 0.821809750370218 -0.989745402399581 -1 3.97980487761459 4580 2460 2410 2266 480 2813 2583 3387 2576 4440 3346 2635 M11139 GO_SECOND_MESSENGER_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECOND_MESSENGER_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. 99/251 Gene Ontology BP GO:0019932 0.0375273873217695 0.100080217883386 1455 2437.90909090909 2584 0.00347120390128739 740 1.11946870355849 1.30594335633033 1 4.24783776629162 1453 2243 740 2702 3162 3337 2111 2584 3262 2166 3057 2636 M13391 GO_VITAMIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 6/24 Gene Ontology BP GO:0009110 0.318369917216001 0.436559812650293 2585 2860.45454545455 2584 0.037601638550471 1159 0.32559063005658 -0.346578184021368 -1 0.444865618418799 2584 2515 4066 3515 2082 1159 1699 4603 3677 3728 1837 2637 M10678 GO_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 123/292 Gene Ontology BP GO:0002064 0.00237954359516937 0.0147506287214571 2530 2513.45454545455 2585 0.000216556476281668 437 1.31241942077139 1.52039763191477 1 9.12248507034312 2527 2699 437 2023 2585 4617 3023 3940 1095 612 4090 2638 M15302 GO_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. 13/24 Gene Ontology BP GO:0055070 0.51616363172336 0.62933765846311 2585 2620.72727272727 2585 0.0638698600607342 1252 1.03069309216194 -1.03069309216194 -1 0.786835278759114 2585 1860 3113 2411 3226 1849 1252 4460 3204 1959 2909 2639 M14163 GO_RESPONSE_TO_PROGESTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROGESTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. 29/72 Gene Ontology BP GO:0032570 0.249745450585897 0.363260554598668 2590 2559 2586 0.0257838367462625 1157 0.909780263674066 0.909780263674066 1 1.51873133515919 2586 1781 1157 1813 2829 4355 2296 2816 3156 1567 3793 2640 M16553 GO_SIALYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLATION.html The covalent attachment of sialic acid to a substrate molecule. 6/21 Gene Ontology BP GO:0097503 0.262575873105072 0.378379819623479 2025 2684.54545454545 2587 0.03 446 0.703777757316276 0.758249218170523 1 1.12753321804913 2025 446 4580 2205 3093 3275 2038 2587 2920 4530 1831 2641 M10109 GO_ATP_DEPENDENT_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. 45/200 Gene Ontology BP GO:0043044 0.20287976508934 0.310676368505873 1450 2389.27272727273 2588 0.0204026056669686 1205 0.426239111324754 -0.520851093087153 -1 0.821411276158882 1448 3089 1213 3930 3499 1541 2731 1205 2588 2957 2081 2642 M12116 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that modulates the activity of the enzyme nitric-oxide synthase. 33/73 Gene Ontology BP GO:0050999 0.0389125224768427 0.102770672275302 2430 2412 2588 0.00360166625294911 843 1.21455215107271 1.21455215107271 1 4.55551872520851 2428 2922 2097 2715 843 3422 1439 2102 3036 2588 2940 2643 M13958 GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 6/18 Gene Ontology BP GO:0001574 0.262575873105072 0.378379819623479 2025 2588.18181818182 2588 0.03 445 0.703777757316276 0.758249218170523 1 1.12753321804913 2024 445 4166 2204 3092 3274 2037 2588 2919 3891 1830 2644 M11186 GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. 7/23 Gene Ontology BP GO:0031645 0.260771671062163 0.376480991524136 3100 2747.36363636364 2590 0.0297629380304333 1904 0.805981699595888 0.511679407932491 1 1.29796019418654 3098 2441 3703 1904 1945 4134 2212 2682 2328 3184 2590 2645 M11558 GO_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SENESCENCE.html A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. 23/66 Gene Ontology BP GO:0090398 0.116198939319343 0.206551177358234 4390 2438.63636363636 2590 0.011166575395787 955 0.990920275534794 0.950017221963614 1 2.57643369860714 4389 955 1952 1376 1385 2880 3397 2940 2590 1293 3668 2646 M14313 GO_ACIDIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSPORT.html The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/26 Gene Ontology BP GO:0015800 0.147859119791321 0.249186894080256 2590 2763.09090909091 2590 0.0158730158730159 439 0.570691061148215 0.67398536874773 1 1.30727646562303 2590 439 4223 1122 2023 3858 4247 4012 1505 3978 2397 2647 M12978 GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. 6/26 Gene Ontology BP GO:0002827 0.00294934661064781 0.0171601708185937 815 2162.72727272727 2591 0.000295326832852814 83 0.498611526951672 0.498611526951672 1 3.34142680538009 814 2653 3988 2591 4186 401 83 1952 2657 3618 847 2648 M13829 GO_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENETIC_IMPRINTING.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 9/23 Gene Ontology BP GO:0071514 0.0421658986968624 0.108946170088777 2595 2511.81818181818 2593 0.00429880237566826 669 0.456051523040467 0.483510376352888 1 1.66667846804999 2593 1803 4140 2952 3489 2267 850 669 3327 3844 1696 2649 M14288 GO_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_POLYMERIZATION.html Assembly of actin filaments by the addition of actin monomers to a filament. 20/38 Gene Ontology BP GO:0030041 0.161385165508919 0.258740097879113 4575 2654.81818181818 2593 0.0158730158730159 1207 1.01230254218223 -0.945090980148163 -1 2.25609021552637 4572 1283 1605 1207 2848 3551 4212 2593 1420 2295 3617 2650 M13949 GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY.html The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. 7/43 Gene Ontology BP GO:0060397 0.100468777335663 0.183003739964489 2715 2601.36363636364 2594 0.0105322943451013 902 0.470209360313782 -0.572737228417816 -1 1.31638856373679 2711 902 4163 1571 1359 2594 3634 3192 2169 3886 2434 2651 M14138 GO_REGULATION_OF_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. 6/19 Gene Ontology BP GO:0033127 0.214139132665174 0.322775948981753 3090 2704.63636363636 2596 0.0238095238095238 1330 1.33403223803043 -1.33403223803043 -1 2.48680915932302 3090 2984 4190 2596 2541 2192 3613 3163 1647 1330 2405 2652 M14373 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 94/240 Gene Ontology BP GO:0043242 0.251121499681773 0.364817622973239 2600 2358.36363636364 2596 0.0259464104405027 698 0.804770103401029 -0.758283505231832 -1 1.33775936940054 2596 2875 1503 2244 3210 698 2795 1908 3047 3993 1073 2653 M15557 GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. 7/31 Gene Ontology BP GO:2001026 0.627131341449345 0.728489071390871 2070 2938.90909090909 2597 0.0939428580287568 1517 0.43414922728334 0.566661904206524 1 0.226721115013819 2247 2582 4422 3687 3277 2066 1517 2066 3563 4304 2597 2654 M10804 GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 8/15 Gene Ontology BP GO:0044090 0.0890069450275087 0.165834368283597 1015 2584.36363636364 2598 0.00927868537939852 881 0.734831567556784 0.734831567556784 1 2.17656084657032 1014 3112 3640 2598 4201 2434 2572 881 2935 3095 1946 2655 M16752 GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT.html Any process that modulates the frequency, rate or extent of synaptic vesicle transport. 22/58 Gene Ontology BP GO:1902803 0.177330084705269 0.27914295920761 2340 2700 2598 0.0175889520685424 542 0.347542996520606 -0.438136084569849 -1 0.731074081125839 2340 3842 2598 4073 3649 542 2387 1715 3153 4582 819 2656 M11444 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. 123/266 Gene Ontology BP GO:0048002 0.224634270873698 0.336770074157759 1825 2656.45454545455 2599 0.0228637039730363 648 1.04199361456204 -0.708329498464269 -1 1.86950709824344 1824 4491 2822 4514 2599 648 2214 1866 3871 2900 1472 2657 M16642 GO_SYNAPSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSIS.html The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. 13/41 Gene Ontology BP GO:0007129 0.0830766710269524 0.158445571591463 1390 2479.63636363636 2599 0.00785367211876311 328 0.290486865326745 -0.317339232515418 -1 0.882244175878774 1388 3291 3050 3419 2494 328 1228 2599 4004 4552 923 2658 M13674 GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-13 production. 20/65 Gene Ontology BP GO:0032656 0.40026158735968 0.521587019396856 1735 2817.27272727273 2600 0.0454147596725738 1569 0.328557107380357 -0.355479083981052 -1 0.352535430890555 1731 3780 2101 3843 2202 1569 2600 3033 4045 3802 2284 2659 M12785 GO_PEPTIDYL_THREONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_THREONINE_MODIFICATION.html The modification of peptidyl-threonine. 44/87 Gene Ontology BP GO:0018210 0.0619574366521732 0.142294194481907 4115 2544.18181818182 2601 0.00579766957120645 1073 1.17636903378415 1.43949717281964 1 3.7812747821626 4112 1220 2395 1720 1073 3408 3087 2601 1574 2697 4099 2660 M11378 GO_CRANIAL_NERVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 15/59 Gene Ontology BP GO:0021602 0.619094810200409 0.720776630832622 2140 2690.09090909091 2602 0.084006388919913 1532 1.31394404283802 1.31394404283802 1 0.709220969072222 2136 2602 1532 2362 3456 3383 2509 3674 3243 2064 2630 2661 M12181 GO_ESTABLISHMENT_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization or cell growth patterns. 69/172 Gene Ontology BP GO:0030010 0.161385165508919 0.258740097879113 4300 2916.09090909091 2602 0.0158730158730159 1614 1.2232052971749 1.38989324121763 1 2.72612325622002 4296 3454 2483 4112 2153 1729 4590 2743 1614 2602 2301 2662 M11286 GO_PROTEIN_NEDDYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_NEDDYLATION.html Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. 7/16 Gene Ontology BP GO:0045116 0.0765897756730953 0.158445571591463 2210 2609.18181818182 2607 0.00793650793650794 643 0.681111565817195 0.681111565817195 1 2.06861921780559 3493 2607 3725 2077 2206 2208 2252 2825 643 3214 3451 2663 M12301 GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 18/74 Gene Ontology BP GO:0070286 0.35943518917414 0.479556776820555 2610 2463.27272727273 2608 0.0396825396825397 1379 1.29644110978073 1.29644110978073 1 1.57061028492401 2608 2849 2825 2855 2278 1379 3292 2956 2235 2195 1624 2664 M13365 GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. 20/65 Gene Ontology BP GO:0046637 0.466738071388703 0.580826820010117 2900 2820.63636363636 2608 0.0555555555555556 1352 0.402614966543748 -0.382304692070443 -1 0.360597965098331 2897 2384 1951 3635 2600 1352 3180 4547 2608 3719 2154 2665 M13952 GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE.html Any process that modulates the frequency, rate or extent of stem cell population maintenance. 7/22 Gene Ontology BP GO:2000036 0.679993065134228 0.770802685893121 2395 2943 2608 0.107689632413801 1617 0.263779682393479 -0.279117092806844 -1 0.113199676601953 2394 2608 4164 3335 4129 1920 1617 2414 3835 3888 2069 2666 M13253 GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT.html The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. 64/205 Gene Ontology BP GO:0060538 0.0183717743309923 0.0623995232032166 2615 2760.45454545455 2611 0.00168427376559134 642 1.44929778125007 1.44634566036874 1 6.62806209371295 2611 2377 642 2542 2721 4239 2820 4241 2213 2001 3958 2667 M10467 GO_MYELOID_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 68/127 Gene Ontology BP GO:0002262 0.0839184282471183 0.158445571591463 3135 2475.27272727273 2612 0.00793650793650794 974 1.29210531209197 1.29210531209197 1 3.92428203289038 2612 3134 2854 1840 2563 4572 2666 1512 974 1370 3131 2668 M11669 GO_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. 658/1788 Gene Ontology BP GO:0016192 0.0643592291268998 0.1466034686914 3980 2702.63636363636 2612 0.00663028878949787 847 1.15976720889311 1.3509681252242 1 3.67086984539581 3976 847 3786 2140 1131 1890 4261 3371 2119 2612 3596 2669 M11915 GO_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. 39/112 Gene Ontology BP GO:0031016 0.0839184282471183 0.158445571591463 3515 2404.90909090909 2612 0.00793650793650794 785 1.46584243959724 1.46584243959724 1 4.45194296080794 3515 785 1191 1801 1708 3524 3223 2612 950 2658 4487 2670 M12191 GO_DNA_CONFORMATION_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CONFORMATION_CHANGE.html A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. 145/419 Gene Ontology BP GO:0071103 0.130463487153006 0.226445596579965 395 2578.09090909091 2612 0.0126282184488457 391 1.2451718004747 -1.2451718004747 -1 3.04874107662447 391 4245 2058 4141 3314 1497 2612 1993 3444 2803 1861 2671 M12056 GO_PEPTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 325/740 Gene Ontology BP GO:0006518 0.0774416805363188 0.158445571591463 2465 2445.90909090909 2613 0.00730091661217192 952 1.54222073587681 1.76667455529576 1 4.68391319806433 2463 3828 3497 3086 1185 952 3711 2785 1035 2613 1750 2672 M12969 GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. 13/34 Gene Ontology BP GO:0030201 0.161385165508919 0.258740097879113 4245 2547.27272727273 2613 0.0158730158730159 821 1.1538764181133 -1.44204098723265 -1 2.57161193258017 4245 821 2613 1389 4053 2894 4045 2011 1256 1941 2752 2673 M10543 GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-DNA complex into its constituent components. 17/41 Gene Ontology BP GO:0032986 0.55187431467806 0.663134690230392 1010 2646.81818181818 2617 0.070372256653499 1007 0.311706743759486 -0.358172594875986 -1 0.211078512449026 1007 2746 2785 2615 3552 1885 2227 2617 4201 3044 2436 2674 M13498 GO_CELLULAR_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. 6/21 Gene Ontology BP GO:0006883 0.182927193112453 0.28645226226682 2620 2244.90909090909 2617 0.02 310 1.38933387508025 1.38933387508025 1 2.86333319767836 2617 310 4087 636 2640 2728 3447 3967 1643 1323 1296 2675 M11924 GO_NUCLEAR_PORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. 7/17 Gene Ontology BP GO:0006999 0.581718045267915 0.688307055091471 1630 2785.54545454545 2619 0.0834695189006091 1303 0.257973170828313 -0.257973170828313 -1 0.158847441122514 1630 3483 3824 4002 2619 1303 1745 2397 4190 3371 2077 2676 M14326 GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS.html The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. 6/16 Gene Ontology BP GO:0060670 0.422301153990598 0.541289402185973 3920 2742.27272727273 2620 0.0533920446130747 1411 0.429362182654481 -0.345136288531462 -1 0.434453267694112 3918 1411 4224 1952 2298 1913 1888 3277 2620 3980 2684 2677 M13317 GO_GLYCOPROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 7/29 Gene Ontology BP GO:0006516 0.0398378609508371 0.104657815359223 905 2424.36363636364 2622 0.00405705920185013 771 0.517790917301752 -0.492746858172233 -1 1.92658826861014 2622 903 4052 1734 904 3189 3472 771 3354 3707 1960 2678 M16717 GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of anion transport. 31/109 Gene Ontology BP GO:1903793 0.0705635396580362 0.156609232615804 2455 2938 2622 0.00663036088566901 785 0.401903973438285 0.453908446027778 1 1.22835509870453 2455 2622 2414 2465 2416 3775 4080 785 3242 4574 3490 2679 M12394 GO_PROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. 656/1551 Gene Ontology BP GO:0070271 0.0647300033330237 0.146900707449814 2895 2186.45454545455 2623 0.00666966090474172 545 1.09375388378561 1.25299232359074 1 3.45827389607305 2895 1297 3903 2623 1134 545 3224 2899 1224 2755 1552 2680 M13670 GO_PIGMENT_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. 14/29 Gene Ontology BP GO:0048753 0.0244316705856577 0.075290790090591 4335 2386.45454545455 2623 0.00224611695407256 108 1.59317129651972 1.59317129651972 1 6.79280708707262 4331 652 2623 777 656 3632 3696 3532 108 2024 4220 2681 M12561 GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 9/50 Gene Ontology BP GO:0071378 0.0226204730050993 0.0717396558488226 2870 2458.90909090909 2624 0.00228540854399991 664 0.475597849023385 -0.537960481676699 -1 2.06568696173965 2868 828 3931 1214 664 2619 3191 3427 2159 3523 2624 2682 M13919 GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 137/336 Gene Ontology BP GO:0006650 0.07031566752109 0.156208442249005 3735 2650.45454545455 2624 0.00660627993865554 963 1.35517780457345 -0.996017559443501 -1 4.14760840871485 3732 1881 2392 1434 1130 3465 3878 3693 963 2624 3963 2683 M16814 GO_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex. 656/1551 Gene Ontology BP GO:0006461 0.0647300033330237 0.146900707449814 2900 2268.90909090909 2624 0.00666966090474172 546 1.09375388378561 1.25299232359074 1 3.45827389607305 2896 1298 4621 2624 1135 546 3225 3079 1225 2756 1553 2684 M14758 GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. 21/55 Gene Ontology BP GO:0060338 0.35943518917414 0.479556776820555 4530 3015.45454545455 2626 0.0396825396825397 1878 0.956375427801259 1.08395202335029 1 1.15862808712317 4530 2068 2626 1878 3003 2358 4569 4152 2191 2331 3464 2685 M12941 GO_CHROMATIN_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DISASSEMBLY.html The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. 17/41 Gene Ontology BP GO:0031498 0.55187431467806 0.663134690230392 1010 2700 2627 0.070372256653499 1008 0.311706743759486 -0.358172594875986 -1 0.211078512449026 1008 2747 2786 2616 3553 1886 2228 2627 4202 3610 2437 2686 M16292 GO_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 168/463 Gene Ontology BP GO:0009416 0.161385165508919 0.258740097879113 2115 2776.72727272727 2627 0.0158730158730159 1464 1.21685149771182 1.25667323930703 1 2.71196272198852 2114 3771 2197 3510 2114 4161 3625 3326 1635 1464 2627 2687 M12060 GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. 36/125 Gene Ontology BP GO:1901616 0.232850105696956 0.342669743502683 1425 2267.72727272727 2628 0.0238095238095238 1061 1.82051220676583 1.82051220676583 1 3.21417708264831 1424 2882 1224 2900 3716 2967 1061 1557 1813 2628 2773 2688 M14704 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE.html The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. 30/50 Gene Ontology BP GO:0006120 0.115224211288579 0.205054048682587 875 2509.36363636364 2628 0.0110674826706683 412 0.564322045552235 -0.564322045552235 -1 1.47402816451432 872 3746 3402 4031 2247 412 818 2628 4277 4076 1094 2689 M14959 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 50/103 Gene Ontology BP GO:0043620 0.415320710913563 0.535202348257472 2630 2723.18181818182 2628 0.0476190476190476 1455 1.42010235024591 1.42010235024591 1 1.46341634276017 2628 2006 2421 1455 3403 4586 2859 1708 2439 2744 3706 2690 M12546 GO_ER_NUCLEUS_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_NUCLEUS_SIGNALING_PATHWAY.html Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. 26/50 Gene Ontology BP GO:0006984 0.448620839854993 0.568024695785855 3140 2604.18181818182 2629 0.0526826615335203 1187 0.628401006665132 0.628401006665132 1 0.585909352521945 3136 2629 2041 2713 2380 1187 3942 1642 3706 3517 1753 2691 M14713 GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. 15/27 Gene Ontology BP GO:0009081 0.00199772515455767 0.0129578024379262 4050 2803.45454545455 2630 0.000181776501105792 142 0.694957063565193 -0.694957063565193 -1 4.97903237857664 4050 965 2630 2429 142 2416 4579 2795 4155 4081 2596 2692 M16454 GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 72/204 Gene Ontology BP GO:0032479 0.161385165508919 0.258740097879113 3785 2860 2630 0.0158730158730159 1586 1.03754753176321 1.12677316597775 1 2.31235301406325 3785 2093 3280 2630 3207 3599 2219 2439 1586 2177 4445 2693 M11508 GO_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_CYCLE.html Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 10/27 Gene Ontology BP GO:0042634 0.286101536395144 0.404743885887464 2125 2693.45454545455 2632 0.0301731077054272 1189 0.384901866043904 0.487647667684978 1 0.573918878311562 2125 3331 1189 3530 3285 2254 2477 2632 3953 3275 1577 2694 M10195 GO_NUCLEOSOME_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_DISASSEMBLY.html The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. 17/41 Gene Ontology BP GO:0006337 0.55187431467806 0.663134690230392 1010 2640.90909090909 2633 0.070372256653499 1006 0.311706743759486 -0.358172594875986 -1 0.211078512449026 1006 2745 2784 2614 3551 1884 2226 2633 4200 2972 2435 2695 M15496 GO_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION.html The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. 21/98 Gene Ontology BP GO:0001708 0.0373279816318808 0.0997776734121027 2990 2470.54545454545 2633 0.00345243644390932 824 1.86534826534151 -2.07333958077616 -1 7.08739693948017 2987 1647 1215 1884 824 3811 4277 2890 2633 1233 3775 2696 M11347 GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM.html The process in which an organism effects a change in the structure or processes of a second organism. 55/206 Gene Ontology BP GO:0035821 0.063791429483623 0.14568795233274 3435 2670.45454545455 2634 0.00597453520094791 1085 1.84601786585865 1.84601786585865 1 5.86203921500905 3432 1317 1484 2634 1085 1781 4091 4096 2691 2427 4337 2697 M11681 GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 224/516 Gene Ontology BP GO:0090407 0.031023819047898 0.0883703017419572 2635 2228.27272727273 2634 0.00286092232625509 299 1.05582384221012 1.16513785837476 1 4.22292203793873 2634 2407 3074 2983 748 299 2332 3199 2887 2865 1083 2698 M11969 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. 268/647 Gene Ontology BP GO:0055086 0.0419639095598706 0.108545087513359 1895 2492.63636363636 2637 0.00388967273360028 696 1.07238198669659 1.25085178017613 1 3.92562998136995 1895 3165 3231 3814 887 696 2603 3454 3303 2637 1734 2699 M10409 GO_SINGLE_ORGANISM_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. 66/146 Gene Ontology BP GO:0044801 0.0897060914744045 0.166802315865302 1525 2367.72727272727 2638 0.00850794224103016 352 0.298219587590017 -0.284919408390037 -1 0.880461105896877 1524 3705 3112 3891 1601 352 1953 2638 3299 3019 951 2700 M11214 GO_RESPONSE_TO_POTASSIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_POTASSIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. 5/20 Gene Ontology BP GO:0035864 0.463179224171846 0.580826820010117 1355 2555.54545454545 2638 0.0603136213259 1260 0.289707425340785 0.344232048791175 1 0.259473483881118 1352 2908 3710 2638 2528 1283 1260 3978 3844 3193 1417 2701 M13926 GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. 73/188 Gene Ontology BP GO:0050852 0.35943518917414 0.479556776820555 4015 2864.27272727273 2638 0.0396825396825397 1293 1.24300374604446 1.24300374604446 1 1.50587207779707 4013 3310 3345 3000 2258 1293 4412 2623 2252 2638 2363 2702 M13358 GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. 936/2297 Gene Ontology BP GO:0006796 0.0325923361841376 0.0915464107095893 4350 2566.54545454545 2639 0.00330804597397581 200 1.23289297688598 1.43362915746459 1 4.85937043190652 4346 1755 4059 2902 910 200 4311 4383 1625 2639 1102 2703 M10281 GO_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGY.html Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 168/374 Gene Ontology BP GO:0010506 0.008827234385846 0.037157614917029 4640 2681.54545454545 2640 0.000805713894548349 355 1.18349425303415 1.38626205272432 1 6.42384266762733 4636 1675 2640 2084 355 1733 4300 4077 2746 1974 3277 2704 M10887 GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. 117/261 Gene Ontology BP GO:0032104 0.0905952251653783 0.168051790029106 2445 2263.72727272727 2640 0.00859602174894713 355 0.802501557958499 0.848699259104514 1 2.35942631249596 2444 2373 3239 2976 1408 355 2641 2640 3065 2893 867 2705 M12807 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. 37/94 Gene Ontology BP GO:1904427 0.0288900396481295 0.0837829194792413 4610 2651.18181818182 2640 0.00266150396158041 721 1.02153487267164 -0.743128926420273 -1 4.17554748041075 4609 3000 1756 2449 721 1260 3994 3319 3157 2640 2258 2706 M13236 GO_RELAXATION_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_MUSCLE.html A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. 19/37 Gene Ontology BP GO:0090075 0.514011397665828 0.627050688219243 2915 2812.63636363636 2640 0.0634920634920635 1954 1.38933387508025 1.38933387508025 1 1.06896116889214 2915 2351 1972 3081 3984 4353 1954 2190 2640 2240 3259 2707 M13838 GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. 34/140 Gene Ontology BP GO:0050829 0.204573200372402 0.3127538259233 3610 2860.72727272727 2640 0.0205919792734477 1211 1.29644110978073 1.29644110978073 1 2.48414594652268 3610 2487 1211 2640 1734 3298 3040 3858 2549 2606 4435 2708 M14673 GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 37/68 Gene Ontology BP GO:1901028 0.000910870282692402 0.0076338821706513 4215 2631.45454545455 2641 8.28406937122453e-05 87 1.39934214282505 -0.554099100968402 -1 11.2461589925751 4214 1779 2505 2107 87 2017 4488 2836 2703 2641 3569 2709 M15781 GO_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 23/56 Gene Ontology BP GO:0046686 0.0839184282471183 0.158445571591463 3505 2601.54545454545 2641 0.00793650793650794 780 0.88632027725861 0.88632027725861 1 2.691863199393 2641 804 2282 1331 3863 3504 780 4407 1150 4350 3505 2710 M13209 GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that modulates the frequency, rate or extent of a response to nutrient levels. 117/261 Gene Ontology BP GO:0032107 0.0905952251653783 0.168051790029106 2445 2278 2642 0.00859602174894713 356 0.802501557958499 0.848699259104514 1 2.35942631249596 2445 2374 3240 2977 1409 356 2642 2787 3066 2894 868 2711 M14428 GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 12/35 Gene Ontology BP GO:0051569 0.422998350682072 0.541873828334142 1660 2502.81818181818 2644 0.0487628060021569 1230 1.33403223803043 -1.33403223803043 -1 1.34747714479361 1656 3434 2799 2996 4310 1230 2571 2644 2744 1881 1266 2712 M14724 GO_UBIQUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. 9/13 Gene Ontology BP GO:0006743 0.325294256575459 0.444741234770276 1415 2506 2644 0.0385837890828026 892 0.272731466060636 -0.29582327437149 -1 0.36429450051568 1414 2032 4282 3454 2644 892 1386 2697 3407 4084 1274 2713 M14871 GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. 22/42 Gene Ontology BP GO:0045839 0.316532556288674 0.434682241599619 675 2458.63636363636 2644 0.0340061791501555 674 0.674350887224881 -0.674350887224881 -1 0.926180127357106 674 3177 2644 3053 2699 1117 1835 1829 3998 4121 1898 2714 M12306 GO_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_ACTIVATION.html The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. 8/42 Gene Ontology BP GO:0045576 0.338197858478603 0.458735803948628 1555 2626.54545454545 2646 0.0404384952543957 986 0.423635540629501 0.461857748338175 1 0.544224288502788 1555 3439 3888 3781 2646 1328 986 1806 4064 3462 1937 2715 M11753 GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. 10/36 Gene Ontology BP GO:0060122 0.0839184282471183 0.158445571591463 3820 2505.63636363636 2647 0.00793650793650794 85 2.76431492756404 2.76431492756404 1 8.39556288657882 3819 2647 1619 1558 2992 4490 3078 1358 85 1684 4232 2716 M13058 GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. 24/62 Gene Ontology BP GO:0032007 0.395355000853494 0.516837596816404 1810 2684.36363636364 2647 0.0447074168053693 1211 1.13830914051267 1.13830914051267 1 1.23854899391785 1806 3749 2426 3197 4359 2647 2702 1751 3264 2416 1211 2717 M14995 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. 22/54 Gene Ontology BP GO:0030837 0.0839184282471183 0.158445571591463 4490 2795.09090909091 2647 0.00793650793650794 566 0.916001837656024 -0.97975757930076 -1 2.78200973241234 4489 797 2647 940 4476 2531 4017 2622 566 4151 3510 2718 M16943 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. 51/143 Gene Ontology BP GO:0002705 0.0707082406655772 0.156780497330599 2245 2509.09090909091 2648 0.0066444213862475 1132 1.11882204112119 1.11882204112119 1 3.41748441793757 2244 3169 1946 3229 1132 2648 1580 2374 3051 2750 3477 2719 M10375 GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-alpha-amino acid across a membrane. 10/33 Gene Ontology BP GO:1902475 0.0448619560483106 0.113821891766287 3890 2741.90909090909 2649 0.00416397925214256 924 0.52764144728938 -0.46548771433251 -1 1.89022818686609 3890 1449 2017 2649 924 3157 4112 2504 2207 3011 4241 2720 M11663 GO_CYTOKINETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINETIC_PROCESS.html A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). 9/20 Gene Ontology BP GO:0032506 0.421599291689205 0.540891271432158 1715 2496.90909090909 2649 0.0532771014226618 1052 0.411748246202224 -0.513333942581157 -1 0.417129912481746 1715 2649 3785 2814 3522 1052 1471 2563 3086 3310 1499 2721 M15087 GO_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 112/329 Gene Ontology BP GO:0016042 0.0274164008377931 0.0810792032419574 4155 2683.81818181818 2649 0.00252401331158615 700 1.10404967970065 -0.685139128689607 -1 4.5725307274819 4151 2336 1332 1770 700 2649 3797 4527 2045 2819 3396 2722 M15060 GO_COCHLEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_MORPHOGENESIS.html The process in which the cochlea is generated and organized. 10/37 Gene Ontology BP GO:0090103 0.298735036746822 0.413174493778819 2950 2609.09090909091 2650 0.0317460317460317 730 1.30628405292381 1.30628405292381 1 1.9033780858292 2950 1742 1214 2274 4502 3952 2650 3016 2001 730 3669 2723 M16217 GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS.html The process in which the branching structure of the salivary gland is generated and organized. 9/33 Gene Ontology BP GO:0060445 0.326640246531735 0.4464500043117 820 2510.36363636364 2650 0.0387757571731958 816 0.496954889437809 0.557050015599442 1 0.660653943763093 816 2650 4529 3003 2682 1059 972 1841 3662 4443 1957 2724 M15431 GO_STRIATUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATUM_DEVELOPMENT.html The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. 10/37 Gene Ontology BP GO:0021756 0.0839184282471183 0.158445571591463 3770 2694.18181818182 2652 0.00793650793650794 59 2.10742452872238 2.10742452872238 1 6.40050631824452 3768 2359 2121 863 2652 4061 4309 4495 59 1711 3238 2725 M13783 GO_VIRAL_LIFE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LIFE_CYCLE.html A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. 184/480 Gene Ontology BP GO:0019058 0.236632152847621 0.347244970186948 1150 2739 2653 0.0242480179284905 764 1.30573381359741 1.46979620985367 1 2.2767684942686 1150 4531 3378 4521 3714 2653 764 2015 2872 2512 2019 2726 M14914 GO_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 38/70 Gene Ontology BP GO:0010332 0.298735036746822 0.413174493778819 4530 2805.36363636364 2653 0.0317460317460317 1448 2.24458518468169 2.24458518468169 1 3.2705706258172 4527 1961 1448 2350 2193 3125 3347 3005 2092 2653 4158 2727 M16379 GO_SUBPALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBPALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. 10/44 Gene Ontology BP GO:0021544 0.0839184282471183 0.158445571591463 3770 2696.09090909091 2653 0.00793650793650794 60 2.10742452872238 2.10742452872238 1 6.40050631824452 3769 2360 2122 864 2653 4062 4310 4497 60 1721 3239 2728 M15233 GO_MUSCULOSKELETAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCULOSKELETAL_MOVEMENT.html The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. 30/75 Gene Ontology BP GO:0050881 0.420050841151891 0.53935178525117 3315 2624.72727272727 2654 0.0483220806979123 1326 1.98725977860331 -3.11553755502548 -1 2.02257133151648 3313 3497 1326 3276 3103 1339 3072 2654 2497 2543 2252 2729 M10113 GO_LIPID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_MODIFICATION.html The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. 110/244 Gene Ontology BP GO:0030258 0.00288027013826531 0.0168215022037306 4385 2750.54545454545 2655 0.000262186177596196 178 1.29604230923917 -0.9328497862405 -1 8.72796766637851 4385 1764 2237 2586 178 2862 4187 4536 1863 2655 3003 2730 M15083 GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 28/59 Gene Ontology BP GO:0051784 0.467476239235906 0.581589544151209 950 2536.09090909091 2655 0.0556744801534024 949 0.674350887224881 -0.674350887224881 -1 0.602516596363772 949 3464 2655 3388 2666 1074 1658 2436 3550 4179 1878 2731 M11711 GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 5/17 Gene Ontology BP GO:0009214 0.0118244752634008 0.0457577240928837 1580 2311.54545454545 2656 0.00118878687211766 177 0.415552613329987 0.632474160443011 1 2.1129416502705 1579 2656 3794 3159 3531 946 177 1413 3197 3323 1652 2732 M12117 GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. 17/35 Gene Ontology BP GO:0060765 0.116444350607946 0.206908197425447 3390 2694.27272727273 2656 0.0111915400348702 1299 1.70820157422404 1.70820157422404 1 4.43653155818002 3387 1442 2656 1342 1387 4296 3907 3482 1299 2146 4293 2733 M12000 GO_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule. 22/83 Gene Ontology BP GO:0070988 0.0839184282471183 0.158445571591463 3290 2720.72727272727 2657 0.00793650793650794 721 2.01369544572059 2.01369544572059 1 6.11583961735131 3289 2210 2657 2899 3392 1604 3726 4569 721 2356 2505 2734 M12058 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation. 68/174 Gene Ontology BP GO:0030856 0.0036548379600809 0.0201211710357104 4540 2153.45454545455 2657 0.000332811260465059 467 1.61881873873401 -1.31824092474771 -1 10.4236563355506 4540 609 467 874 2718 3295 3883 2657 842 642 3161 2735 M13660 GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. 38/88 Gene Ontology BP GO:1901222 0.0839184282471183 0.158445571591463 2175 2676.27272727273 2658 0.00793650793650794 893 1.93660894790567 1.93660894790567 1 5.88171848532267 2174 4321 1367 3339 3882 3782 2742 1630 893 2651 2658 2736 M14300 GO_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 40/100 Gene Ontology BP GO:0046631 0.232850105696956 0.342669743502683 3130 2687 2658 0.0238095238095238 1217 1.31105205751639 1.40450504596788 1 2.31470762001872 3127 3621 1497 3593 2658 3418 2575 2075 1846 1217 3930 2737 M14930 GO_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_SYSTEM_PROCESS.html A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. 161/419 Gene Ontology BP GO:0003012 0.000264134599327312 0.0029480215016267 1995 2693.72727272727 2658 2.40151197246177e-05 304 1.63719885527984 1.49460137368958 1 15.7256912710179 1991 2152 304 2658 2940 4456 3062 4364 2048 1834 3822 2738 M11561 GO_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the meiotic cell cycle. 24/61 Gene Ontology BP GO:0051445 0.161385165508919 0.258740097879113 4455 2885.18181818182 2659 0.0158730158730159 1350 1.42750535851956 -1.38916827744188 -1 3.18144105920969 4455 2887 2059 2611 2402 3321 4180 4361 1452 1350 2659 2739 M12291 GO_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by the detection of a hormone. 66/264 Gene Ontology BP GO:0009755 0.232850105696956 0.342669743502683 3615 2931.09090909091 2659 0.0238095238095238 1784 1.42598549646385 1.42598549646385 1 2.51762657004953 3615 3312 2116 1784 1861 4224 2659 4415 1802 2047 4407 2740 M13141 GO_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 5/19 Gene Ontology BP GO:0070528 0.0119758373013541 0.0460816150833625 1990 2522.90909090909 2660 0.00120408704082745 463 0.665455983212677 -0.665455983212677 -1 3.3758763397364 1986 3123 4019 2660 463 707 591 4565 4310 3659 1669 2741 M15049 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. 39/76 Gene Ontology BP GO:0072332 0.743118215456021 0.824640983356192 2035 2807.36363636364 2660 0.116229721942479 1785 1.05077947290469 1.05077947290469 1 0.333984473767247 2031 3712 2774 3753 3521 2576 1785 2144 3588 2660 2337 2742 M14937 GO_REGULATION_OF_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cilium assembly. 32/66 Gene Ontology BP GO:1902017 0.00861757687196694 0.0365735003807518 1615 2135.72727272727 2661 0.000786501717724521 291 0.755777475721829 -0.755777475721829 -1 4.12199643958999 1614 2809 3180 2661 3696 395 797 291 3440 4131 479 2743 M16920 GO_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. 54/127 Gene Ontology BP GO:0007030 0.0340101002548946 0.0938816263278691 3090 2354 2661 0.00314068502290958 783 1.10736149226976 -0.644965665499241 -1 4.31861419871408 3086 1683 3305 2179 783 1164 2661 4545 2751 2768 969 2744 M13568 GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. 18/43 Gene Ontology BP GO:0048713 0.146427962197698 0.248943620828968 2460 2646.81818181818 2662 0.014290125394015 1050 0.849254971022537 0.849254971022537 1 1.94674755410974 2456 2783 2146 2619 2884 3141 2064 1050 3534 3776 2662 2745 M11070 GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. 16/46 Gene Ontology BP GO:0045747 0.18565023679307 0.289739176279067 1990 2493.81818181818 2664 0.0184963776173359 677 0.43222253597872 -0.339220470602599 -1 0.882655201005626 1988 1547 1991 2843 3418 2153 677 3701 3294 3156 2664 2746 M12282 GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 106/233 Gene Ontology BP GO:0010822 0.225679709177492 0.33790096411193 3885 2761.90909090909 2667 0.0229835491554036 652 1.06742143940097 1.33168187382829 1 1.90922967278824 3885 1765 3121 2667 3614 652 2735 4456 2574 2636 2276 2747 M15506 GO_CEREBRAL_CORTEX_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_CELL_MIGRATION.html The orderly movement of cells from one site to another in the cerebral cortex. 17/66 Gene Ontology BP GO:0021795 0.514011397665828 0.627050688219243 3340 2726.18181818182 2667 0.0634920634920635 1042 1.18063890866154 1.18063890866154 1 0.908390107260974 2509 3783 1880 3340 3725 3190 3337 1975 2667 1042 2540 2748 M11633 GO_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_SECRETION.html The controlled release of a peptide from a cell or a tissue. 27/82 Gene Ontology BP GO:0002790 0.277156940966064 0.394448909366395 1995 2597.63636363636 2668 0.0290746963241898 1181 1.7354036805309 1.7354036805309 1 2.66133192382681 1994 3048 1181 3295 2668 3263 2497 2145 2958 2491 3034 2749 M12547 GO_ETHANOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. 6/17 Gene Ontology BP GO:0006067 0.147859119791321 0.249186894080256 2670 2505.18181818182 2670 0.0158730158730159 673 0.694918460929748 0.713857489204404 1 1.59184296262612 2670 673 3928 1204 2321 2681 2598 3116 1317 3518 3531 2750 M11744 GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. 17/82 Gene Ontology BP GO:0021515 0.466738071388703 0.580826820010117 4420 2895.72727272727 2671 0.0555555555555556 1435 1.48620652365728 -1.48620652365728 -1 1.33110562913009 4420 2168 1435 2484 2671 3110 3783 3138 2552 2145 3947 2751 M10724 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 21/68 Gene Ontology BP GO:0051966 0.232850105696956 0.342669743502683 3975 2405.27272727273 2672 0.0238095238095238 663 1.41162063952148 -1.4227640217421 -1 2.49226491973451 3971 1485 1635 1181 3604 2882 2672 3533 1725 663 3107 2752 M12831 GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL.html Any process that modulates the potential difference across a post-synaptic membrane. 18/76 Gene Ontology BP GO:0060078 0.298735036746822 0.413174493778819 2590 2691.36363636364 2672 0.0317460317460317 1066 1.16170000063765 1.07946141055207 1 1.69270559381533 2587 2848 1898 2612 3282 3622 3981 2672 2087 1066 2950 2753 M13290 GO_REGULATION_OF_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of fatty acid transport. 16/57 Gene Ontology BP GO:2000191 0.191386054574362 0.297391382660229 2675 2771.18181818182 2672 0.019126867375676 1181 0.391287320940271 -0.289706063784904 -1 0.782245229323526 2672 2499 2546 3007 2058 3555 3336 1181 2491 3697 3441 2754 M16278 GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 10/19 Gene Ontology BP GO:0060315 0.313856467658348 0.431390047169245 2825 2997.63636363636 2672 0.033662943316433 1719 1.29994081892301 1.29994081892301 1 1.80168218920258 2823 4231 2501 3651 2027 4458 2630 2662 2672 1719 3600 2755 M16803 GO_NEUROPEPTIDE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. 18/105 Gene Ontology BP GO:0007218 0.38751863285238 0.508118896451172 2745 2977.45454545455 2672 0.0435884605845928 1283 0.513887472189023 0.482529579620361 1 0.573553294916282 2743 2672 1283 3407 2626 2591 2433 4382 2381 4596 3638 2756 M13514 GO_REGULATION_OF_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of ion homeostasis. 113/303 Gene Ontology BP GO:2000021 0.00425794652225507 0.0223638526050116 1855 2419.36363636364 2673 0.000387837261800258 481 1.32743501821078 1.47351154115841 1 8.31617773246995 1854 3204 481 2752 2072 4026 2713 2092 1569 2673 3177 2757 M13723 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. 13/32 Gene Ontology BP GO:1902307 0.369434782861308 0.490221691004588 3945 2790.27272727273 2673 0.0410551362651924 1177 0.415876080203512 -0.484919261977528 -1 0.488745320381127 3942 1177 2673 2183 2138 2164 2344 3687 3402 3817 3166 2758 M14603 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE.html The directed movement of a protein to a specific location in a vacuole. 28/44 Gene Ontology BP GO:0072666 0.665349711011147 0.758975695142582 3290 2855.09090909091 2673 0.094723975513747 1404 1.48034281358945 1.48034281358945 1 0.673015875542192 3287 2382 3046 2560 2673 1404 3620 4363 3055 2521 2495 2759 M14947 GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. 18/50 Gene Ontology BP GO:0045143 0.285982735550774 0.404737965925444 1705 2766.18181818182 2674 0.0301584369739235 766 0.279819727464132 -0.298981544928595 -1 0.417239912828553 1704 3985 2982 3601 2357 766 2157 2674 4211 4134 1857 2760 M16083 GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI.html The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. 10/21 Gene Ontology BP GO:0000301 0.297757250589893 0.413174493778819 2675 2648.72727272727 2674 0.031623377311934 786 0.301389022839365 -0.296032849555511 -1 0.439152005201415 2674 2271 2917 3272 2752 786 2139 2017 4233 4417 1658 2761 M16510 GO_ERYTHROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. 16/33 Gene Ontology BP GO:0048821 0.415320710913563 0.535202348257472 3795 2795.90909090909 2674 0.0476190476190476 1789 1.65735694990685 1.65735694990685 1 1.70790735322902 3794 2642 1789 2735 2674 2145 2945 3933 2363 2123 3612 2762 M14193 GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of cytoplasmic transport. 325/775 Gene Ontology BP GO:1903649 0.0581050950140678 0.136598458810287 3780 2541.18181818182 2676 0.00542718084814607 875 1.20791185930303 1.3272463621966 1 3.96400963573751 3776 3033 1731 3399 1038 875 4046 2321 2676 1902 3156 2763 M16186 GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycosyl compound. 22/46 Gene Ontology BP GO:1901658 0.119042943682209 0.210603063722062 1590 2600.63636363636 2676 0.011456271243168 418 1.0296882537552 -1.0296882537552 -1 2.64425577394666 1587 4095 2676 4242 3465 418 786 3705 4222 2370 1041 2764 M10473 GO_REGULATION_OF_T_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. 5/13 Gene Ontology BP GO:0010819 0.0765897756730953 0.158445571591463 4030 2496 2677 0.00793650793650794 476 1.46584243959724 1.46584243959724 1 4.45194296080794 4028 750 3592 1410 1412 4319 3306 2677 476 1179 4307 2765 M13201 GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER.html The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. 9/16 Gene Ontology BP GO:0006390 0.20642268557311 0.314752226310656 1660 2536.36363636364 2677 0.0228552017475529 854 0.20032650760103 -0.218749825059495 -1 0.381747630237381 1657 3962 4031 3652 2677 900 854 1256 4042 3669 1200 2766 M16457 GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. 13/43 Gene Ontology BP GO:0007212 0.455583605869421 0.575115465484427 2560 2885 2677 0.0537764669302102 1149 0.347755190308225 -0.342217664360125 -1 0.317128391981598 2557 2677 2233 3238 4098 1149 2357 3340 4251 4507 1328 2767 M15746 GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 199/495 Gene Ontology BP GO:0072521 0.0467228286725133 0.116756778001334 2240 2433.81818181818 2678 0.00434051414515023 865 1.07265953230688 1.27384299804103 1 3.79768936364259 2237 2333 3203 2827 939 865 2678 3941 2995 2746 2008 2768 M10325 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. 9/25 Gene Ontology BP GO:0061339 0.214139132665174 0.322775948981753 3840 2808.72727272727 2679 0.0238095238095238 1579 1.46584243959724 1.46584243959724 1 2.73252047515736 3836 2083 3566 2355 3028 2542 4409 2679 1687 1579 3132 2769 M13301 GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 13/33 Gene Ontology BP GO:0010644 0.466738071388703 0.580826820010117 1145 2606.36363636364 2679 0.0555555555555556 1141 1.38933387508025 1.38933387508025 1 1.24434263502787 1141 2679 2766 3378 4334 1955 3111 2691 2585 1944 2086 2770 M12728 GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. 24/51 Gene Ontology BP GO:1901224 0.0839184282471183 0.158445571591463 2695 2646.90909090909 2680 0.00793650793650794 396 3.21934379747048 3.21934379747048 1 9.77754127641277 2691 3748 1304 1800 4486 4530 3985 1081 396 2415 2680 2771 M16408 GO_REGULATION_OF_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROPTOTIC_PROCESS.html Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. 10/18 Gene Ontology BP GO:0060544 0.466738071388703 0.580826820010117 4025 3061.63636363636 2680 0.0555555555555556 1760 0.889829409089437 -0.889829409089437 -1 0.796966583341461 4024 2467 2680 2410 2742 2568 4146 3866 2524 4491 1760 2772 M16136 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT.html The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 27/55 Gene Ontology BP GO:1901264 0.35943518917414 0.479556776820555 2960 2634.63636363636 2681 0.0396825396825397 1647 1.90919498657043 1.90919498657043 1 2.31294831621658 2958 3747 2879 3072 2681 1812 1647 2517 2188 2502 2978 2773 M15784 GO_REGULATION_OF_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_CONDUCTION.html Any process that modulates the frequency, rate or extent of cardiac conduction. 31/91 Gene Ontology BP GO:1903779 0.514011397665828 0.627050688219243 3190 2888.72727272727 2682 0.0634920634920635 1668 1.26454268131947 -1.13975148755868 -1 0.972946134086811 3189 2664 1711 2316 4086 3801 2237 3051 2682 1668 4371 2774 M11870 GO_GABAERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABAERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. 4/21 Gene Ontology BP GO:0097154 0.19469480747084 0.301624287983687 2685 2817.18181818182 2683 0.0214206434457969 1091 1.14672566625037 1.14672566625037 1 2.26576888005669 2683 2405 3819 2535 3472 3724 4287 1226 3744 1091 2003 2775 M12910 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. 42/120 Gene Ontology BP GO:0002708 0.101772464990882 0.18508795728659 2465 2727.45454545455 2683 0.00970999270934826 1316 1.11882204112119 1.11882204112119 1 3.11134452716401 3055 2414 1937 2788 1316 3527 2462 3059 2463 2683 4298 2776 M13789 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. 14/27 Gene Ontology BP GO:0034198 0.266549608084404 0.382917645524718 4045 2909.27272727273 2683 0.0277880010003719 916 0.954077893911041 1.10805759676357 1 1.50979281789543 4044 3290 2504 2252 1898 3882 3320 2683 2629 916 4584 2777 M14790 GO_PEPTIDYL_PROLINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_MODIFICATION.html The modification of peptidyl-proline. 23/55 Gene Ontology BP GO:0018208 0.0839184282471183 0.158445571591463 4495 2948.90909090909 2683 0.00793650793650794 1030 1.8636644772713 1.8636644772713 1 5.66017719697476 4491 2493 2338 2683 2759 2550 4104 2979 1030 2395 4616 2778 M11684 GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html A process in which a protein is transported to, or maintained in, the cell periphery. 84/212 Gene Ontology BP GO:1990778 0.0839184282471183 0.158445571591463 2525 2753.72727272727 2685 0.00793650793650794 866 1.27423861919708 1.4542667280917 1 3.87001869904165 2525 3132 2321 2317 3519 4302 2685 3875 932 866 3817 2779 M14683 GO_REPLICATIVE_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATIVE_SENESCENCE.html A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. 10/22 Gene Ontology BP GO:0090399 0.187525085894182 0.292174152284124 2570 2660.63636363636 2685 0.0187020185083828 1293 1.05077947290469 1.05077947290469 1 2.13133293215576 2568 2685 1293 2382 1685 3499 3549 3113 3217 1705 3571 2780 M16053 GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION.html The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. 42/99 Gene Ontology BP GO:0035335 0.264317257556949 0.380299047671804 1695 2509.27272727273 2686 0.02751936769836 1331 0.903622821473322 0.903622821473322 1 1.44017143458982 1695 3529 2639 2825 3144 2506 1364 1331 2993 2686 2890 2781 M11277 GO_PH_REDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PH_REDUCTION.html Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. 24/49 Gene Ontology BP GO:0045851 0.161385165508919 0.258740097879113 3335 2891.54545454545 2687 0.0158730158730159 1304 1.50252579399645 1.85303616796089 1 3.34863699461883 3333 3425 1479 2141 4499 3512 2687 2558 1304 2413 4456 2782 M14203 GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epidermal cell differentiation. 30/67 Gene Ontology BP GO:0045604 0.514011397665828 0.627050688219243 3320 2842.09090909091 2687 0.0634920634920635 1510 1.52111690612723 -1.33403223803043 -1 1.17035576198324 4442 1642 1510 2096 2408 3320 4084 4108 2687 1647 3319 2783 M11449 GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 4/12 Gene Ontology BP GO:0046349 0.370542875653767 0.491411188706209 4050 3036.81818181818 2688 0.0452347248040671 1808 0.429848537454906 -0.396391222633783 -1 0.503448690636661 4046 2236 3747 1808 2197 4108 2314 2688 2473 3253 4535 2784 M15618 GO_DORSAL_VENTRAL_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 14/35 Gene Ontology BP GO:0009950 0.466738071388703 0.580826820010117 2855 2786.72727272727 2688 0.0555555555555556 1759 1.38975139692581 -1.38975139692581 -1 1.24471658418643 2852 1859 1846 1759 2688 3377 3175 4215 2492 2031 4360 2785 M14537 GO_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. 116/208 Gene Ontology BP GO:0007033 0.0526427004951094 0.127209326646132 1925 2405.63636363636 2689 0.00490420408774122 255 1.57523637036235 1.84784412020038 1 5.35438209410647 1921 4056 3188 3415 1786 255 1753 3097 2954 2689 1348 2786 M10141 GO_DENTATE_GYRUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENTATE_GYRUS_DEVELOPMENT.html The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. 6/19 Gene Ontology BP GO:0021542 0.259869447534085 0.375295130606767 3335 2575.18181818182 2690 0.0296445861939068 1367 0.431773286870862 -0.388858487078202 -1 0.697577143982902 3335 2185 3542 3033 2514 1993 2923 1367 2690 2963 1782 2787 M13361 GO_CELLULAR_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. 81/197 Gene Ontology BP GO:0044242 0.0038014113289854 0.0206673920380318 4115 2680.09090909091 2690 0.000346181434142981 217 1.33902843533954 -0.736186088956347 -1 8.56294784303449 4114 2616 1286 1774 217 3480 3203 3605 2218 2690 4278 2788 M13990 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. 51/106 Gene Ontology BP GO:0042590 0.619691846974767 0.721024416080517 2100 3051.72727272727 2690 0.0841370040744081 1312 0.246715067324934 -0.245685080180587 -1 0.133028357572222 2100 4219 3376 4405 2602 1312 2636 2690 4120 3898 2211 2789 M13091 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. 63/138 Gene Ontology BP GO:0002474 0.392087883477465 0.513674955695788 2040 2940.36363636364 2695 0.0442393113704993 950 0.243152617656851 -0.24000651056033 -1 0.267025070878196 2040 4317 3400 4409 2695 950 2320 2403 4182 3648 1980 2790 M13094 GO_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. 810/1884 Gene Ontology BP GO:0065003 0.0479353598196162 0.118890959210725 2660 2366.36363636364 2695 0.00490018942089702 466 1.11036057812178 1.27368365316498 1 3.89801149287956 2660 2695 4010 3569 987 466 3000 2734 1628 2880 1401 2791 M11399 GO_MULTICELLULAR_ORGANISMAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MOVEMENT.html Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. 30/75 Gene Ontology BP GO:0050879 0.420050841151891 0.53935178525117 3315 2627.63636363636 2696 0.0483220806979123 1325 1.98725977860331 -3.11553755502548 -1 2.02257133151648 3312 3496 1325 3275 3102 1338 3071 2696 2496 2542 2251 2792 M12134 GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 11/26 Gene Ontology BP GO:0071257 0.352880352045547 0.476979177451957 3445 2677.45454545455 2696 0.0387933194597042 1762 1.01405746558881 -1.01405746558881 -1 1.23751809542496 3441 3103 2325 2828 2101 1762 3467 2515 3428 1786 2696 2793 M14305 GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. 13/27 Gene Ontology BP GO:0035883 0.0839184282471183 0.158445571591463 2820 2715.27272727273 2697 0.00793650793650794 485 1.46584243959724 1.46584243959724 1 4.45194296080794 2817 2122 1752 2697 4447 4045 2094 4444 485 1952 3013 2794 M14986 GO_HISTONE_H3_K4_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_TRIMETHYLATION.html The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. 7/18 Gene Ontology BP GO:0080182 0.197454607510796 0.304882521673636 2065 2834.27272727273 2698 0.0217565232243357 1161 0.328671230396439 -0.411845865496396 -1 0.643586708018044 2065 4111 4331 4181 2698 1161 2506 1229 3531 4148 1216 2795 M15818 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. 26/61 Gene Ontology BP GO:1901016 0.440564018869459 0.559501843438429 3080 2964.45454545455 2698 0.0514325500833913 1627 1.13975148755868 -1.13975148755868 -1 1.09108820364535 3080 2628 2294 2698 2679 3913 3763 1627 3448 2476 4003 2796 M13698 GO_AMINO_SUGAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 7/17 Gene Ontology BP GO:0046348 0.0765897756730953 0.158445571591463 2925 2428.90909090909 2700 0.00793650793650794 4 3.21934379747048 3.21934379747048 1 9.77754127641277 2921 2323 4118 651 2700 4254 4264 1112 4 1414 2957 2797 M11173 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. 9/22 Gene Ontology BP GO:2000010 0.147859119791321 0.249186894080256 1195 2560 2701 0.0158730158730159 1195 1.21455215107271 1.21455215107271 1 2.78216280501851 1195 2756 3701 2701 3532 2996 2533 3542 1300 1589 2315 2798 M11304 GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 33/82 Gene Ontology BP GO:0033143 0.0572773299170374 0.135368812869288 4145 2653.09090909091 2701 0.00534775257160163 1028 1.70820157422404 1.70820157422404 1 5.63127660799881 4142 1728 2817 1454 1028 2701 3729 3862 2353 2587 2783 2799 M14323 GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. 20/54 Gene Ontology BP GO:0031663 0.374494844955163 0.495378793483425 2300 3019.81818181818 2701 0.0417572640035254 1270 1.29644110978073 1.29644110978073 1 1.50123602146858 3862 2299 1270 2202 4611 3847 3340 2172 2701 2296 4618 2800 M14368 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex assembly. 115/268 Gene Ontology BP GO:0031334 0.0839184282471183 0.158445571591463 2705 2591.90909090909 2701 0.00793650793650794 1143 1.15797126479187 1.33560850053529 1 3.51690050839982 2701 2990 2663 1946 1620 3725 3915 1248 1143 2829 3731 2801 M10889 GO_COFACTOR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORT.html The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. 13/27 Gene Ontology BP GO:0051181 0.161385165508919 0.258740097879113 3955 2871.09090909091 2702 0.0158730158730159 1273 0.427016571014945 -0.334455311009509 -1 0.951679826422338 3951 3102 2403 2556 1934 2702 3428 4465 1273 3112 2656 2802 M13153 GO_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 15/40 Gene Ontology BP GO:0010939 0.259760263777403 0.375254170727592 2760 2498.18181818182 2702 0.0269732874772811 952 0.889829409089437 -0.889829409089437 -1 1.43777719997201 2756 2172 2754 2229 2320 1210 3701 3022 2702 3662 952 2803 M10610 GO_NEGATIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. 35/78 Gene Ontology BP GO:0051782 0.681833212711068 0.772511373015492 2205 2761.63636363636 2703 0.0988713370453073 1612 0.674350887224881 -0.674350887224881 -1 0.286932579730417 2202 3653 2451 3246 2703 1612 2427 2920 3762 3060 2342 2804 M11437 GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. 12/44 Gene Ontology BP GO:0045920 0.396981148613396 0.518330560464566 2050 2829.63636363636 2703 0.0449412653955949 1033 0.328517589950686 0.440029025182113 1 0.35588481410874 2049 3817 2070 3903 3458 2703 1033 2416 4139 3251 2287 2805 M14999 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. 22/62 Gene Ontology BP GO:2000649 0.35943518917414 0.479556776820555 3845 3045.27272727273 2703 0.0396825396825397 1434 1.38933387508025 1.38933387508025 1 1.68314785526963 3843 1434 2300 2223 3431 4005 4439 2703 2253 2365 4502 2806 M15561 GO_PEPTIDYL_LYSINE_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_TRIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. 14/28 Gene Ontology BP GO:0018023 0.143200925804113 0.244711777147036 1515 2537.72727272727 2703 0.0139519243553333 614 0.309614698032784 -0.368307259068124 -1 0.71848094824671 1515 4019 2703 4051 3615 614 1662 1171 3575 4306 684 2807 M16113 GO_MIDGUT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDGUT_DEVELOPMENT.html The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. 9/25 Gene Ontology BP GO:0007494 0.0765897756730953 0.158445571591463 2895 2396.18181818182 2704 0.00793650793650794 559 1.46584243959724 1.46584243959724 1 4.45194296080794 2892 572 4511 559 4472 2891 2090 2704 609 1630 3428 2808 M13390 GO_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINESIS.html Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. 35/100 Gene Ontology BP GO:0032465 0.413403968220598 0.535202348257472 2685 2449.45454545455 2705 0.0473356358806759 991 0.967843427962502 -0.862559895960135 -1 0.997363245957634 2684 2705 2725 2789 2792 991 3198 1590 3134 2617 1719 2809 M11766 GO_SPERM_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MOTILITY.html Any process involved in the controlled movement of a sperm cell. 34/121 Gene Ontology BP GO:0030317 0.232850105696956 0.342669743502683 3815 2790.90909090909 2706 0.0238095238095238 1516 1.34288749243049 1.34288749243049 1 2.37091417822931 3811 2706 2683 3083 3530 1568 3740 4373 1854 1836 1516 2810 M13524 GO_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of T cell proliferation. 84/232 Gene Ontology BP GO:0042129 0.159765353723376 0.258740097879113 4270 3027.54545454545 2706 0.0157003607486548 1033 1.00932819086 1.01422388797511 1 2.24946136235597 4270 2375 1033 2268 2466 3221 3930 4409 2603 2706 4022 2811 M16622 GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE.html Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. 20/40 Gene Ontology BP GO:0043094 0.069307405078497 0.15418988106347 1095 2476.81818181818 2706 0.0065083866752769 292 0.260758537563868 -0.281968784090683 -1 0.803659184280815 1093 4015 2706 4319 2931 292 599 1644 4497 4548 601 2812 M10786 GO_VESICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. 176/377 Gene Ontology BP GO:0016050 0.00878017646294604 0.0370529497491828 4120 2739.81818181818 2708 0.000801401373001235 353 1.21397913314575 1.34094516145792 1 6.59495544096006 4120 3035 2708 2880 353 2013 3919 2595 2265 2431 3819 2813 M16543 GO_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_PATTERNING.html The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. 19/52 Gene Ontology BP GO:0021532 0.726270090971166 0.809038395484434 4445 3088.09090909091 2708 0.111111111111111 2039 1.49234186417521 1.49234186417521 1 0.521325618312219 4444 2424 2536 2708 4242 2195 2039 4192 3164 2255 3770 2814 M15603 GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. 10/24 Gene Ontology BP GO:0070861 0.422129437807513 0.541272294874423 3310 2930.45454545455 2709 0.0486326697719559 1531 0.340101703519148 -0.356648726856996 -1 0.344152118232811 3306 2683 2542 3883 2237 2176 2769 2709 4087 4312 1531 2815 M10201 GO_INORGANIC_ION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_IMPORT_INTO_CELL.html The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 10/26 Gene Ontology BP GO:0099587 0.514011397665828 0.627050688219243 2945 2835.81818181818 2710 0.0634920634920635 2252 0.410921621792081 -0.376461388012356 -1 0.316165368785402 2695 2432 2487 2944 4165 2252 2947 2945 2710 2975 2642 2816 M10258 GO_EMBRYONIC_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEMOPOIESIS.html The stages of blood cell formation that take place within the embryo. 15/26 Gene Ontology BP GO:0035162 0.0655669308102908 0.14799575097335 935 2078.81818181818 2710 0.00614606038032978 278 0.301874897000889 -0.346822191916607 -1 0.950784047104078 935 3012 3173 2710 3455 278 497 1849 3118 2988 852 2817 M12093 GO_INORGANIC_CATION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_IMPORT_INTO_CELL.html The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 10/26 Gene Ontology BP GO:0098659 0.514011397665828 0.627050688219243 2700 2874.27272727273 2711 0.0634920634920635 2253 0.410921621792081 -0.376461388012356 -1 0.316165368785402 2696 2433 2488 2945 4166 2253 2948 2924 2711 3410 2643 2818 M12234 GO_GPI_ANCHOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GPI_ANCHOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. 16/33 Gene Ontology BP GO:0006505 0.227592397173874 0.340429854133148 1850 2296.72727272727 2712 0.0232031938922482 750 0.946863186450032 -0.946863186450032 -1 1.68195614121429 1850 2712 3209 2738 3844 1085 750 1370 3032 3442 1232 2819 M10730 GO_NADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. 12/41 Gene Ontology BP GO:0006739 0.415320710913563 0.535202348257472 3705 2814.27272727273 2713 0.0476190476190476 1755 1.09476899510989 -1.09476899510989 -1 1.12816012075183 3705 2713 2448 2246 4044 1755 2857 3854 2346 1854 3135 2820 M11967 GO_SYNAPTIC_VESICLE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYCLE.html A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. 42/129 Gene Ontology BP GO:0099504 0.514011397665828 0.627050688219243 1545 2780.45454545455 2713 0.0634920634920635 1541 1.51935086267539 -1.51935086267539 -1 1.16899695838191 3339 3741 2584 3818 2421 1543 2855 3348 2713 2682 1541 2821 M11295 GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 12/29 Gene Ontology BP GO:0010832 0.751985672431077 0.832094727620946 1895 2863.72727272727 2714 0.119047619047619 1891 0.406646797409599 0.441153050214401 1 0.123218422702711 1891 2714 2223 3484 4454 2694 2438 2306 3203 3216 2878 2822 M13550 GO_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. 334/846 Gene Ontology BP GO:0006325 0.196686211568034 0.30410059284395 1035 2510.27272727273 2715 0.0197130933657256 594 1.19791783987442 -1.10107554815415 -1 2.35077087818371 1031 4526 3181 4359 4104 594 1977 1293 2715 2907 926 2823 M11074 GO_CELLULAR_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. 27/63 Gene Ontology BP GO:0006879 0.298735036746822 0.413174493778819 2690 3112.45454545455 2716 0.0317460317460317 2114 1.31212748984869 -0.831099373833084 -1 1.9118925201629 2689 3978 2716 3819 2642 3590 2321 3873 2114 2489 4006 2824 M13429 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 122/268 Gene Ontology BP GO:0015931 0.395303988805953 0.516837596816404 1975 2784.90909090909 2716 0.044700090258078 956 1.21648013088035 -0.903367480678587 -1 1.32360374577874 1974 4492 3447 4592 2716 956 2452 1834 3714 2840 1617 2825 M15571 GO_RESPONSE_TO_SALT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. 7/19 Gene Ontology BP GO:1902074 0.0263790960902686 0.0794206949397192 3055 2535.09090909091 2716 0.00266975652454844 560 1.18499600693363 -1.01405746558881 -1 4.94815146638668 3051 1127 4425 1243 723 4325 4251 2249 2716 560 3216 2826 M13161 GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 9/21 Gene Ontology BP GO:0002183 0.17139732837763 0.272207586077444 1060 2302.63636363636 2717 0.018625807715083 567 0.340486772590376 -0.415446107858757 -1 0.730352652350797 1058 2717 4026 3355 3350 567 1406 1450 2838 3665 897 2827 M15396 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. 17/46 Gene Ontology BP GO:0032736 0.689215778691716 0.778974893005267 1380 2964.90909090909 2717 0.10079253100933 1380 0.310061895394093 -0.328233424724975 -1 0.12767076228192 1380 4199 2078 4328 2717 1540 2402 3242 4203 4258 2267 2828 M13150 GO_TETRAHYDROFOLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. 9/20 Gene Ontology BP GO:0046653 0.52340095663996 0.635617084269422 2880 2855.90909090909 2718 0.0714285714285714 1603 0.964916235402726 -0.810865129405406 -1 0.72082814078009 2877 2361 4023 1775 4596 1740 2152 4286 2718 1603 3284 2829 M14061 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. 34/86 Gene Ontology BP GO:0032106 0.289876056605771 0.40834178726353 2720 2751.54545454545 2719 0.0306403830181683 1686 0.734831567556784 0.734831567556784 1 1.08497076697869 2719 1686 3020 2423 1959 3644 2215 2580 3111 3911 2999 2830 M15178 GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. 20/54 Gene Ontology BP GO:0032727 0.514011397665828 0.627050688219243 4075 3073.54545454545 2719 0.0634920634920635 1965 1.29644110978073 1.29644110978073 1 0.997488961402132 4072 2167 2884 2709 3755 1965 4155 4403 2678 2302 2719 2831 M16723 GO_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_TRANSPORT.html The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 35/102 Gene Ontology BP GO:0015833 0.331671341771336 0.4523942537733 2350 2896.36363636364 2719 0.0359712018239516 1234 1.7354036805309 1.7354036805309 1 2.26921392039825 2348 3803 1234 3904 2719 3932 2309 2485 3115 2623 3388 2832 M11703 GO_ENDOCARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. 7/14 Gene Ontology BP GO:0003157 0.713459773824661 0.799564018795052 2145 2706.54545454545 2720 0.117492185025288 1666 0.468391936687108 0.622824065939972 1 0.172720923637863 2141 1666 3791 1834 3724 2720 1830 3076 3741 3318 1931 2833 M13042 GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. 11/21 Gene Ontology BP GO:0009200 0.545360492537978 0.656827423412031 1785 2691.90909090909 2720 0.0691518630474897 1396 0.272113411955604 -0.257634778962026 -1 0.188554099035315 1784 3397 2967 3213 2720 1396 2354 2713 3932 3634 1501 2834 M13316 GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 8/43 Gene Ontology BP GO:2000516 0.0518438187567031 0.125960675294282 2385 2643.27272727273 2720 0.0053094589464497 382 0.499557090215321 -0.317309093727609 -1 1.70616670773704 2384 2720 4051 3177 3333 2793 382 1637 2707 3706 2186 2835 M14771 GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a steroid hormone binding to a receptor. 58/224 Gene Ontology BP GO:0043401 0.161385165508919 0.258740097879113 3220 2837.36363636364 2720 0.0158730158730159 1517 1.42598549646385 1.42598549646385 1 3.1780537853758 3220 3589 1751 2119 2201 4012 2720 4374 1517 1831 3877 2836 M16372 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. 34/86 Gene Ontology BP GO:0032109 0.289876056605771 0.40834178726353 2720 2803.90909090909 2720 0.0306403830181683 1687 0.734831567556784 0.734831567556784 1 1.08497076697869 2720 1687 3021 2424 1960 3645 2216 2575 3112 4483 3000 2837 M11087 GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. 32/90 Gene Ontology BP GO:0046928 0.161385165508919 0.258740097879113 2150 2646.54545454545 2721 0.0158730158730159 1484 1.8544892661016 1.8544892661016 1 4.13304808973435 2150 3322 1512 2557 3495 3876 2842 3410 1484 1743 2721 2838 M12800 GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. 20/41 Gene Ontology BP GO:2000272 0.298735036746822 0.413174493778819 2725 2651.72727272727 2722 0.0317460317460317 1148 1.22434911985281 1.50407119657352 1 1.7839912222013 2722 3983 2153 3413 2029 3611 1598 3462 2015 1148 3035 2839 M15446 GO_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRINOLYSIS.html A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. 5/29 Gene Ontology BP GO:0042730 0.0271204414196118 0.0805380953779729 2155 2533.09090909091 2723 0.00274572239344806 730 0.654524525745892 0.813234758812048 1 2.71800305077289 2152 1254 4407 1695 730 3428 3297 1021 2723 4274 2883 2840 M10136 GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 131/337 Gene Ontology BP GO:0046394 0.194633215459958 0.301624287983687 2945 2676.09090909091 2727 0.0194856048672605 1089 1.05110541209647 -1.05213417838241 -1 2.0768366859336 2945 1417 1089 2716 2727 3553 2910 2898 2097 2573 4512 2841 M10822 GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. 29/53 Gene Ontology BP GO:0043496 0.0269356465161757 0.0802196056244435 2855 2606.90909090909 2727 0.00247919985333636 695 2.24458518468169 2.24458518468169 1 9.3356100919932 2854 3174 2727 3743 695 988 3159 4390 2070 2530 2346 2842 M12359 GO_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 276/935 Gene Ontology BP GO:0034220 0.0461764348874186 0.115860574033061 2730 2383.45454545455 2727 0.00428864709048473 650 1.31222976601728 1.46578651964394 1 4.66254256293401 2727 1509 767 2895 2311 2848 3373 3635 1174 650 4329 2843 M13689 GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex assembly. 218/505 Gene Ontology BP GO:0043254 0.298735036746822 0.413174493778819 2645 2619.63636363636 2727 0.0317460317460317 1657 1.02811975973777 1.13031705004923 1 1.49806668454964 2642 2727 3152 1844 2080 2829 2986 1657 2118 2892 3889 2844 M11689 GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. 131/337 Gene Ontology BP GO:0016053 0.194633215459958 0.301624287983687 2950 2684.27272727273 2728 0.0194856048672605 1090 1.05110541209647 -1.05213417838241 -1 2.0768366859336 2946 1418 1090 2717 2728 3554 2911 2978 2098 2574 4513 2845 M13769 GO_MICROGLIAL_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROGLIAL_CELL_ACTIVATION.html The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 18/50 Gene Ontology BP GO:0001774 0.298735036746822 0.413174493778819 3480 2838.54545454545 2728 0.0317460317460317 1887 1.14309325609016 -0.989745402399581 -1 1.66559382609196 3477 2710 2728 2190 4265 1887 3325 3620 1999 2202 2821 2846 M14180 GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 42/97 Gene Ontology BP GO:0009124 0.0770980767834971 0.158445571591463 1355 2559.09090909091 2728 0.00726731071513666 878 0.648828184364399 0.648828184364399 1 1.97057063568441 1351 3236 3266 3336 1184 878 2368 2728 4147 3939 1717 2847 M16423 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 5/33 Gene Ontology BP GO:0090208 0.147859119791321 0.249186894080256 2155 2695.45454545455 2728 0.0158730158730159 1211 1.90919498657043 1.90919498657043 1 4.37337439532391 2153 3870 4563 2483 3087 3908 2922 1477 1248 1211 2728 2848 M12400 GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY.html The disaggregation of a macromolecular complex into its constituent components. 135/249 Gene Ontology BP GO:0032984 0.627295053929082 0.728496982339351 1375 2942.45454545455 2729 0.085816884099013 1325 0.751302067173766 0.751302067173766 1 0.392331006487019 1375 4030 3468 4416 2632 1325 2729 2355 4175 3478 2384 2849 M15692 GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 26/54 Gene Ontology BP GO:0006213 0.69596913908471 0.784697599021445 4405 3010.63636363636 2729 0.102586671611539 1567 1.0296882537552 -1.0296882537552 -1 0.4115586902121 2291 4401 2801 3979 2729 1567 2369 4066 4401 2475 2038 2850 M14640 GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosyl compound. 194/462 Gene Ontology BP GO:1901657 0.0813120896603368 0.158445571591463 1260 2333.18181818182 2731 0.00768024695692088 634 1.09798479799848 1.26697418856769 1 3.33471426424346 1259 3372 3405 3333 1206 634 2181 2950 3062 2731 1532 2851 M14720 GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY.html A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. 37/97 Gene Ontology BP GO:0060135 0.00235023317245977 0.0146471578788332 2885 2516.90909090909 2731 0.000213886150852442 434 1.72235498783841 1.88894834303668 1 11.9918898222319 2885 2620 434 1128 3683 4271 3353 3091 2375 1115 2731 2852 M11335 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. 19/45 Gene Ontology BP GO:0002475 0.640684858188847 0.737041574967992 1900 2867.36363636364 2732 0.0888525091106047 1346 0.275471238337875 -0.245195660558837 -1 0.138556095399086 1900 4016 2847 4206 2732 1346 2336 2486 4323 3226 2123 2853 M12857 GO_POSITIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_GROWTH.html Any process that activates or increases the frequency, rate, extent or direction of cell growth. 103/233 Gene Ontology BP GO:0030307 0.232850105696956 0.342669743502683 3960 2916.36363636364 2732 0.0238095238095238 1549 1.74750563525931 1.74750563525931 1 3.08528146296511 3957 2732 1549 2278 3035 1901 4552 3708 1886 2230 4252 2854 M14331 GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 29/118 Gene Ontology BP GO:0030816 0.0336144260733068 0.0932003951166524 3365 2943 2732 0.00310357207361048 731 0.936519733884973 -1.01405746558881 -1 3.66358962819115 3364 2381 731 2732 2553 3649 2435 4640 3223 2533 4132 2855 M12005 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 45/100 Gene Ontology BP GO:0010595 0.288673336009857 0.407018007620335 4020 2898.09090909091 2733 0.0304912448794967 1192 1.41088849393785 1.41088849393785 1 2.0907137507162 4019 1221 1192 2468 3238 4180 3852 2733 2422 2178 4376 2856 M12270 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. 56/124 Gene Ontology BP GO:0090317 0.522592426398101 0.635617084269422 4345 2901.27272727273 2734 0.0650075185858269 1644 1.18774485983252 1.36870232873206 1 0.887289370477097 4344 2734 2503 2692 4111 1644 3766 1770 2851 1750 3749 2857 M13914 GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. 278/639 Gene Ontology BP GO:0010256 0.197827519420429 0.305255291681307 2735 2829.36363636364 2734 0.0198397881478899 1716 1.32295526738942 1.52314440845863 1 2.58787649557522 2734 3164 2507 3738 1716 2225 3106 3263 2289 1987 4394 2858 M14055 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 21/31 Gene Ontology BP GO:2001267 0.466738071388703 0.580826820010117 2735 3051 2735 0.0555555555555556 2328 1.86280643978199 1.86280643978199 1 1.66840348132667 2735 3386 2547 3745 3085 3937 4191 2469 2544 2328 2594 2859 M12316 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. 72/212 Gene Ontology BP GO:1902107 0.0241264559403822 0.0749056652950379 4160 2546.36363636364 2736 0.00221774320884535 685 1.43992446817495 1.43992446817495 1 6.15158151078931 4159 1768 685 1440 2736 3061 4089 3310 885 1480 4397 2860 M12450 GO_CELL_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. 131/292 Gene Ontology BP GO:0034330 0.00161864395896038 0.0111174022210844 2415 2743 2736 0.000147257827268146 407 1.42797050068579 1.61587910710904 1 10.591324851192 2414 3521 407 2736 3860 4291 3637 2259 1615 1747 3686 2861 M10548 GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 11/33 Gene Ontology BP GO:0009261 0.557443745451391 0.666249592815201 4000 2766.45454545455 2737 0.0714285714285714 1123 1.0296882537552 -1.0296882537552 -1 0.689319515454527 3996 1123 2405 2291 2751 3222 4245 3509 2737 1773 2379 2862 M10118 GO_ACYLGLYCEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. 14/41 Gene Ontology BP GO:0055090 0.31198685245507 0.429074335292917 1855 2584.54545454545 2738 0.033423867356762 1420 1.31505585488108 1.31505585488108 1 1.83429980375757 1855 3886 3004 3608 3076 1939 2143 1420 2738 2005 2756 2863 M10940 GO_CELLULAR_RESPONSE_TO_SUPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_SUPEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. 7/21 Gene Ontology BP GO:0071451 0.00685529704422042 0.0311135329191744 4015 2653.54545454545 2738 0.000687653711404343 321 1.03069309216194 -1.03069309216194 -1 5.89609471560664 4011 1054 3660 1795 321 4186 2738 3865 3492 1398 2669 2864 M11593 GO_TRIGLYCERIDE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. 14/41 Gene Ontology BP GO:0070328 0.299943934421873 0.414722956379022 1860 2584 2739 0.031897892148805 1397 1.31505585488108 1.31505585488108 1 1.90804999033029 1856 3887 3005 3609 3077 1940 2144 1397 2739 2013 2757 2865 M13601 GO_REGULATION_OF_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS.html Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. 10/27 Gene Ontology BP GO:0042481 0.35943518917414 0.479556776820555 2890 2891.09090909091 2739 0.0396825396825397 1383 0.612651396751372 -0.36623075789911 -1 0.742213878771959 2886 1982 1383 2727 2739 4486 4408 1547 2236 3785 3623 2866 M15152 GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 7/21 Gene Ontology BP GO:0071450 0.00685529704422042 0.0311135329191744 4015 2722 2739 0.000687653711404343 322 1.03069309216194 -1.03069309216194 -1 5.89609471560664 4012 1055 4361 1796 322 4187 2739 3883 3493 1424 2670 2867 M16315 GO_CENTROMERE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROMERE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. 28/52 Gene Ontology BP GO:0034508 0.527763433291726 0.639625586210776 1555 2807.36363636364 2739 0.0659327470329432 1442 0.436535735531634 -0.51505213589899 -1 0.321584252865454 1552 2739 1442 3926 3355 2148 3257 2100 3376 4468 2518 2868 M16326 GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. 12/22 Gene Ontology BP GO:2000479 0.501375407942812 0.617968149476632 1820 2771.63636363636 2741 0.0613041858128036 1235 0.372918416613812 -0.15053109787291 -1 0.295895120052966 1820 3065 2331 3440 4264 2462 1235 1734 2922 4474 2741 2869 M16936 GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 24/58 Gene Ontology BP GO:0002067 0.0839184282471183 0.158445571591463 4605 2640.54545454545 2741 0.00793650793650794 669 1.38443462101966 -1.34373071173087 -1 4.20469744853774 4602 2741 1287 1934 3727 4611 2647 2751 669 752 3325 2870 M11098 GO_RESPONSE_TO_TYPE_I_INTERFERON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TYPE_I_INTERFERON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 50/123 Gene Ontology BP GO:0034340 0.163521193597895 0.261172652863786 3845 2855.36363636364 2743 0.0161011583807587 1586 1.01514929688902 1.17211282698193 1 2.24677487566533 3845 1774 2510 2365 1586 3269 3770 3295 2573 2743 3679 2871 M16880 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin depolymerization. 9/21 Gene Ontology BP GO:0030836 0.52340095663996 0.635617084269422 2250 3117.45454545455 2743 0.0714285714285714 1626 0.491052058151631 -0.463730159898452 -1 0.366834061893569 2250 2230 4629 2487 4034 2004 3190 4481 2743 4618 1626 2872 M12516 GO_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_PROLIFERATION.html The expansion of a leukocyte population by cell division. 38/127 Gene Ontology BP GO:0070661 0.0839184282471183 0.158445571591463 2745 2638.72727272727 2744 0.00793650793650794 779 1.81687673106179 -1.38916827744188 -1 5.51807708323059 2744 2737 2179 1481 3983 3477 3495 2965 779 1994 3192 2873 M12919 GO_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_PHOSPHORYLATION.html The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 46/99 Gene Ontology BP GO:0006119 0.180017498765513 0.282467471026791 615 2482.90909090909 2744 0.0178811352765886 547 0.564322045552235 -0.564322045552235 -1 1.17606562430884 614 3652 3476 3977 1971 547 1179 2744 4250 3603 1299 2874 M10352 GO_CELLULAR_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 12/40 Gene Ontology BP GO:0098586 0.150027558726214 0.252018073504274 3630 2798.18181818182 2746 0.0146687457760776 1092 1.35593454827845 1.35593454827845 1 3.08077285923869 3630 2531 2596 2746 1538 1092 3645 4303 3438 1853 3408 2875 M13589 GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT.html The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 12/29 Gene Ontology BP GO:0034219 0.297131940599277 0.413174493778819 1530 2908.63636363636 2746 0.031545019193485 1393 0.394380609972948 0.483517649084656 1 0.574649448301042 1526 3688 1924 4310 4131 2308 2127 1393 4060 3782 2746 2876 M10207 GO_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION.html The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. 22/80 Gene Ontology BP GO:0051899 0.35943518917414 0.479556776820555 3975 2974.45454545455 2747 0.0396825396825397 1255 1.40606340631805 -1.42279293755586 -1 1.70341531950597 3975 2708 2283 2747 3309 3659 3580 2480 2180 1255 4543 2877 M10886 GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 91/209 Gene Ontology BP GO:0031330 0.0423265757654108 0.109077806722957 3805 2513.72727272727 2747 0.00392395856746214 342 1.33056096229427 -0.660234687715436 -1 4.85999774502504 3803 3416 2585 3094 889 342 3687 3834 2686 2747 568 2878 M16090 GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell. 9/32 Gene Ontology BP GO:1902187 0.201237821533124 0.30861876712258 2410 2858 2747 0.0222186501958814 1370 0.319178838709895 -0.296101409901045 -1 0.618590344165395 2410 2541 4506 3525 1773 1370 2747 2828 3874 4420 1444 2879 M13400 GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT.html Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. 10/37 Gene Ontology BP GO:0060632 0.138478353497745 0.238219709258996 1315 2252.36363636364 2748 0.0134590690945588 458 0.743128926420273 -0.743128926420273 -1 1.75741770028301 1313 3362 3001 2748 3665 458 813 1684 3258 3730 744 2880 M12278 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C.html The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. 5/17 Gene Ontology BP GO:0006122 0.54382662034294 0.656011171278844 1940 2802.72727272727 2749 0.0754870607587697 1255 0.196566125880902 -0.233933031191655 -1 0.136608462596933 1938 2519 3880 3078 2749 1255 3157 2527 4183 3454 2090 2881 M12483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. 16/34 Gene Ontology BP GO:0014912 0.21948531925229 0.330116727336697 2750 2592.09090909091 2749 0.0222755821365553 738 1.02046556337643 1.03582564386486 1 1.86445000917853 2749 2817 1759 1305 4055 4293 738 2983 2538 2109 3167 2882 M14837 GO_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATPASE_ACTIVITY.html Any process that modulates the rate of ATP hydrolysis by an ATPase. 51/124 Gene Ontology BP GO:0043462 0.097311011778746 0.178583014896726 3160 2481.54545454545 2749 0.00926384243158766 373 1.98725977860331 -3.11553755502548 -1 5.64360060647646 3156 1957 1225 3124 4226 373 2606 3759 2850 2749 1272 2883 M15311 GO_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 44/99 Gene Ontology BP GO:0006637 0.0856029520956032 0.160522821720471 2755 2375.63636363636 2749 0.00810248690891241 537 0.722840167654169 -0.722840167654169 -1 2.17983339799158 2753 1840 2836 3873 1242 537 2004 2749 3184 4235 879 2884 M12280 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. 3/15 Gene Ontology BP GO:1901722 0.253049775318274 0.366815518826958 1945 2918.45454545455 2750 0.0287541721597663 977 0.427130933124443 -0.581575679234603 -1 0.706168865413986 1941 2328 3881 2750 4290 2617 2032 4477 3355 3455 977 2885 M12598 GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 13/35 Gene Ontology BP GO:0033146 0.159259307615624 0.258740097879113 2750 2714.63636363636 2750 0.0156464835158198 726 0.207521576203325 -0.253687271115634 -1 0.462497502407985 2750 4264 3155 4153 2536 1045 1458 1757 4483 3534 726 2886 M11049 GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. 77/173 Gene Ontology BP GO:0045931 0.514011397665828 0.627050688219243 2400 2934.54545454545 2751 0.0634920634920635 1470 1.63032675202175 -1.16188882021501 -1 1.25438242154663 2400 3524 1609 2751 3583 4590 1470 3952 2683 2276 3442 2887 M10448 GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that stimulates, induces or increases the rate of macrophage activation. 7/16 Gene Ontology BP GO:0043032 0.275742742869669 0.392721949430635 2905 2726.63636363636 2752 0.0317460317460317 1161 1.46584243959724 1.46584243959724 1 2.25854857607359 2901 3443 3587 3892 3771 2488 1161 2752 1982 1394 2622 2888 M10618 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. 11/24 Gene Ontology BP GO:1901032 0.240375383053615 0.351848330238945 2675 2698.36363636364 2752 0.0246839605939183 878 0.316365198249067 0.425800862142844 1 0.544768000193285 2673 2715 2752 3012 3945 3235 878 1281 3896 3061 2234 2889 M11634 GO_THIOESTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 44/99 Gene Ontology BP GO:0035383 0.0856029520956032 0.160522821720471 2755 2304.72727272727 2752 0.00810248690891241 536 0.722840167654169 -0.722840167654169 -1 2.17983339799158 2752 1839 2835 3872 1241 536 2003 2910 3183 3303 878 2890 M15162 GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organonitrogen compound. 560/1252 Gene Ontology BP GO:1901566 0.0858378423636175 0.160768496205839 2310 2446.90909090909 2753 0.0089345781039654 499 1.22389648727305 1.30276062119812 1 3.68775868484343 2308 3559 4363 3162 1284 499 2781 3037 1901 2753 1269 2891 M12248 GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. 11/22 Gene Ontology BP GO:0030970 0.131510065701121 0.228002608768885 2755 2555.18181818182 2754 0.012736314479851 931 0.522536967759313 0.522536967759313 1 1.27350305338791 2754 2899 3058 3418 1463 931 1960 1971 4176 3446 2031 2892 M13364 GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. 17/41 Gene Ontology BP GO:0048485 0.381526783256598 0.503019636538229 2870 2617.45454545455 2755 0.0427416298375288 1582 0.792904243146179 -0.792904243146179 -1 0.898149662429764 2870 2784 1987 3015 2160 1582 2755 2296 3882 3718 1743 2893 M13323 GO_HEART_VALVE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_FORMATION.html The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. 9/24 Gene Ontology BP GO:0003188 0.0765897756730953 0.158445571591463 2845 2268.27272727273 2756 0.00793650793650794 392 1.24967114279224 -0.791140711360448 -1 3.7954042652559 2842 835 4053 680 3773 2944 1706 2756 392 1606 3364 2894 M13644 GO_OUTER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 15/61 Gene Ontology BP GO:0036158 0.161385165508919 0.258740097879113 3405 2767.27272727273 2757 0.0158730158730159 1509 1.29644110978073 1.29644110978073 1 2.88934185280965 3403 2785 2757 2679 2831 2188 3755 4085 1509 2076 2372 2895 M11639 GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. 72/188 Gene Ontology BP GO:0034249 0.0166091003093483 0.0581569025160665 4290 2674.72727272727 2758 0.00152143943317209 531 1.13893730097417 1.26323169007576 1 5.34089695650306 4290 1830 2601 2820 531 1199 3465 4094 2758 2175 3659 2896 M11653 GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. 28/52 Gene Ontology BP GO:0008154 0.161385165508919 0.258740097879113 3470 2877.09090909091 2759 0.0158730158730159 1533 1.01230254218223 -0.945090980148163 -1 2.25609021552637 3468 2294 1933 1901 2881 4509 2759 3243 1533 2520 4607 2897 M12149 GO_NEGATIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 32/67 Gene Ontology BP GO:0010507 0.47041237391843 0.584772329880394 2595 2937.18181818182 2760 0.0561490027653655 1454 1.44535183644384 -0.646118488205991 -1 1.27838394141027 2595 4166 2449 3862 2325 3975 1454 2942 2760 2577 3204 2898 M13359 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. 87/215 Gene Ontology BP GO:0051092 0.456109090873764 0.575622318273141 2870 2863.36363636364 2760 0.0538595324543041 1149 1.07649676420207 1.13871921590628 1 0.980126407759645 2869 1767 2020 2760 4132 4112 1149 2661 2959 2730 4338 2899 M14627 GO_CERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. 40/80 Gene Ontology BP GO:0006672 0.0839184282471183 0.158445571591463 4400 2845.63636363636 2761 0.00793650793650794 975 1.54049643392023 1.54049643392023 1 4.67867628190549 4400 1320 2320 1690 2761 2792 4414 4144 975 2053 4433 2900 M11006 GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. 10/18 Gene Ontology BP GO:0009208 0.401629843373681 0.523076399097897 1590 2482.09090909091 2762 0.0456129481121393 970 0.252806930054389 -0.302841252002386 -1 0.270068615888067 1588 3507 3210 3774 2762 970 1039 1837 4221 3138 1257 2901 M11738 GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. 98/242 Gene Ontology BP GO:0043409 0.329041073442031 0.449334618820985 2565 2850.36363636364 2762 0.035626906098926 1454 1.26135879451937 1.26135879451937 1 1.6634637338525 2565 4216 2175 3141 2307 4402 2762 1454 2314 2775 3243 2902 M10981 GO_SUCKLING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUCKLING_BEHAVIOR.html Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. 7/21 Gene Ontology BP GO:0001967 0.0574625435801685 0.135565553733728 3135 2798.09090909091 2763 0.00590048524492092 1080 0.389047677087526 -0.490310934261218 -1 1.28160752734163 3134 2763 3666 3568 1080 2635 2700 1786 3690 3129 2628 2903 M14907 GO_PROTEIN_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPHOSPHORYLATION.html The process of removing one or more phosphoric residues from a protein. 94/224 Gene Ontology BP GO:0006470 0.0735466704736824 0.158445571591463 2455 2641.27272727273 2763 0.00692063293727093 1152 1.35061027587611 1.35061027587611 1 4.10196877101827 2453 3039 3069 3462 1152 3698 1630 1743 2714 2763 3331 2904 M16279 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that activates or increases the activity of the enzyme nitric-oxide synthase. 15/27 Gene Ontology BP GO:0051000 0.152260428430233 0.254846852632146 2685 2854 2763 0.0149043414183958 1548 0.405119332711346 0.403581537296282 1 0.913003430165057 2681 2025 2523 2360 1548 3345 2763 3238 3012 4459 3440 2905 M15895 GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. 14/31 Gene Ontology BP GO:0050849 0.0481225296712513 0.119227804302892 2765 2724.63636363636 2764 0.00447350575936401 951 1.29994081892301 1.29994081892301 1 4.55748548883836 2764 3685 1914 3431 951 4089 2562 2211 2840 2033 3491 2906 M11917 GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. 6/26 Gene Ontology BP GO:0051156 0.0765897756730953 0.158445571591463 3250 2585.81818181818 2766 0.00793650793650794 508 1.09476899510989 -1.09476899510989 -1 3.32494747714069 3247 2832 3822 1785 3328 2766 4548 1600 508 1314 2694 2907 M13351 GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY.html A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. 7/24 Gene Ontology BP GO:0007597 0.0002356710009215 0.00274240716109905 1410 2517.36363636364 2766 2.35695998021909e-05 41 1.42267534279842 1.42267534279842 1 13.8347015835038 2144 2869 4058 2766 3528 3362 3972 41 1409 1408 2134 2908 M15816 GO_PYRUVATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRUVATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. 29/83 Gene Ontology BP GO:0006090 0.557443745451391 0.666249592815201 3490 3015.81818181818 2766 0.0714285714285714 1569 1.50049685841841 1.50049685841841 1 1.00449991897763 3488 2561 1636 2579 4576 2413 3661 3700 2766 1569 4225 2909 M12989 GO_ORGANELLE_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_FUSION.html The joining of two lipid bilayers to form a single organelle membrane. 51/104 Gene Ontology BP GO:0090174 0.288650264952829 0.407018007620335 2465 2948 2768 0.030488386294883 772 0.255205909629057 -0.254300877870241 -1 0.378174821478506 2462 4252 3221 4539 2310 772 2768 2653 4334 3621 1496 2910 M15312 GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 17/34 Gene Ontology BP GO:0090181 0.663463319783461 0.758360461288678 3460 2774.63636363636 2770 0.0942612550645002 1698 1.33376424024472 -1.33376424024472 -1 0.608159135638641 3458 1698 1989 2676 2983 2770 4224 3750 3090 2156 1727 2911 M11460 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/65 Gene Ontology BP GO:0010765 0.304338651895074 0.41979927532645 3355 2869.18181818182 2771 0.0324519677993163 1229 0.858982002181133 0.858982002181133 1 1.22909265508497 3354 1229 2704 2232 2006 3497 4477 1937 2771 3258 4096 2912 M15105 GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 135/306 Gene Ontology BP GO:0009123 0.121469507777401 0.213872933109773 1045 2414.63636363636 2771 0.0117041187712554 681 1.12069556436674 1.25978894407037 1 2.84950004934841 1041 3520 3372 3391 1418 681 2161 3002 3660 2771 1544 2913 M13802 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. 55/128 Gene Ontology BP GO:2001251 0.252822623177432 0.36670372077809 1350 2551.72727272727 2772 0.0261477659349932 702 0.978889588504004 -0.978889588504004 -1 1.61887468879365 1346 4061 2987 3846 2963 702 2519 1877 3841 2772 1155 2914 M14806 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. 37/110 Gene Ontology BP GO:0008543 0.514011397665828 0.627050688219243 2515 3026.45454545455 2772 0.0634920634920635 1972 1.30228212347134 1.30228212347134 1 1.00198306964728 2515 3531 2517 2772 4028 3845 2036 4103 2679 1972 3293 2915 M12200 GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 38/100 Gene Ontology BP GO:0009118 0.207225191643179 0.31566488346433 2775 2591 2773 0.020889284062294 753 1.03069309216194 -1.03069309216194 -1 1.95919712040924 2773 3459 2820 3858 1743 753 3463 3006 2597 2649 1380 2916 M15849 GO_DORSAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. 9/28 Gene Ontology BP GO:0021516 0.356853083929646 0.479556776820555 2825 2788.63636363636 2773 0.043178293564201 1463 0.401752404296546 -0.399621011380171 -1 0.486714323745507 2825 2468 4466 2773 2170 1463 1838 3221 3529 4364 1558 2917 M16125 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST.html Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. 78/211 Gene Ontology BP GO:0050691 0.557443745451391 0.666249592815201 2570 3065.27272727273 2773 0.0714285714285714 2412 1.17916653285703 1.41813868093395 1 0.789386982061166 2569 2701 2412 3925 4069 3594 2901 2716 2773 2675 3383 2918 M15607 GO_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of ATP metabolic process. 38/100 Gene Ontology BP GO:1903578 0.207225191643179 0.31566488346433 2775 2595.45454545455 2774 0.020889284062294 754 1.03069309216194 -1.03069309216194 -1 1.95919712040924 2774 3460 2821 3859 1744 754 3464 3041 2598 2654 1381 2919 M13725 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 14/61 Gene Ontology BP GO:0071380 0.119425254566814 0.210963726100429 2775 2564.81818181818 2775 0.0114952789849093 289 0.551813486055657 0.627242809269505 1 1.41550929043955 2775 289 1080 1988 1405 4049 3841 1802 3846 3818 3320 2920 M14685 GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. 206/456 Gene Ontology BP GO:0034248 0.0832492764307003 0.158445571591463 3335 2533.63636363636 2775 0.00787065227074835 524 1.24830351020046 1.34690610782669 1 3.79125059762714 3332 2728 3331 3547 1216 524 2875 3125 2775 2645 1772 2921 M10683 GO_AMIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSPORT.html The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 47/124 Gene Ontology BP GO:0042886 0.0182223494907585 0.0620736380671988 2845 2910.81818181818 2776 0.00167045971817767 640 1.7354036805309 1.7354036805309 1 7.95148794492995 2841 2619 640 3810 2607 4434 3147 2500 2776 2726 3919 2922 M13752 GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of chemokine production. 36/101 Gene Ontology BP GO:0032722 0.210861426074957 0.319896671324082 3575 2855.63636363636 2776 0.0212984017951805 1222 1.38114177468899 1.38114177468899 1 2.5950286821111 3573 2776 1851 2714 3607 3442 4101 1222 1890 1915 4321 2923 M10643 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. 11/31 Gene Ontology BP GO:2001014 0.323588460822875 0.442576307458776 3870 2873.18181818182 2778 0.0349170633128274 1800 0.408084892725621 -0.390217287323348 -1 0.548372332120263 3870 1800 2477 2595 2048 3081 3622 2669 3599 3066 2778 2924 M10720 GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 28/91 Gene Ontology BP GO:0048168 0.35943518917414 0.479556776820555 2165 2776.09090909091 2778 0.0396825396825397 1545 1.27840814233382 -1.24287224182961 -1 1.54876373599145 2778 3383 2162 3305 2165 4207 2163 2954 2287 1545 3588 2925 M14253 GO_REGULATION_OF_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ISOTYPE_SWITCHING.html Any process that modulates the frequency, rate or extent of isotype switching. 10/29 Gene Ontology BP GO:0045191 0.241239972130541 0.352780217512473 3895 2932.18181818182 2778 0.0247849296239294 1836 0.374507207526586 -0.349245049311748 -1 0.643253178729087 3894 2859 2747 3316 1836 1910 3647 2758 2778 3959 2550 2926 M10238 GO_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_SECRETION.html The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. 15/54 Gene Ontology BP GO:0014047 0.108841506874234 0.195493662056893 2920 2683.81818181818 2779 0.0104210465972686 1356 0.404293191619855 0.406843173982986 1 1.08784898942726 2916 2171 2707 2779 1356 3911 3174 2078 2414 2983 3033 2927 M12729 GO_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. 455/1026 Gene Ontology BP GO:0009894 0.0798723944196569 0.158445571591463 4400 2851.81818181818 2780 0.007538976172323 317 1.19461835450539 1.34180404060654 1 3.62820220678392 4397 3586 2780 3184 1515 317 4572 3517 2763 2343 2396 2928 M15775 GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 73/203 Gene Ontology BP GO:0043271 0.0839184282471183 0.158445571591463 3210 2539.45454545455 2780 0.00793650793650794 930 1.5891632040602 1.64461995956165 1 4.82648322138669 3207 2048 1091 2165 2780 3696 3084 3196 930 1539 4198 2929 M12658 GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 17/48 Gene Ontology BP GO:0097237 0.154611218030571 0.258222980329476 2785 2825 2781 0.0151529894679866 1555 1.79887914043011 1.79887914043011 1 4.01504408016841 2781 3599 2383 2239 1555 3591 4363 2861 3246 2148 2309 2930 M14399 GO_GDP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. 7/17 Gene Ontology BP GO:0046710 0.0721585852268344 0.158445571591463 2400 2603.36363636364 2782 0.00746146899713829 913 0.282091233455602 -0.283552234651216 -1 0.856745613958284 2398 3115 4234 2879 1193 913 2021 2782 4053 4002 1047 2931 M10187 GO_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. 57/182 Gene Ontology BP GO:0006694 0.0353368719397767 0.0961785994461194 3745 2842 2783 0.00326523282918845 799 0.87611537251624 -0.947040535988886 -1 3.38186278801952 3744 1575 2539 2720 799 4312 4371 3133 1232 2783 4054 2932 M13856 GO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING.html The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. 105/235 Gene Ontology BP GO:0006457 0.0886892783563731 0.165375228678169 2130 2823 2783 0.00840731034561027 346 0.268373400949169 -0.276918501850502 -1 0.796144868113656 2126 3935 3427 4586 2783 346 2634 2430 3712 3856 1218 2933 M16008 GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of ARF protein signal transduction. 8/16 Gene Ontology BP GO:0032012 0.340895917522683 0.461990585247465 2685 2845.63636363636 2784 0.0408304123194046 988 0.313994850403377 -0.317649092788731 -1 0.399714515816807 2685 2440 4493 2784 3574 1835 988 2882 3398 4399 1824 2934 M11667 GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 227/602 Gene Ontology BP GO:0045088 0.296312022464586 0.413174493778819 3150 2790.90909090909 2785 0.0314423705381245 1984 1.14641099287249 1.21000938661096 1 1.67042807900388 3148 2193 2375 2756 1984 3025 2785 2310 2794 2814 4516 2935 M13803 GO_COENZYME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 76/138 Gene Ontology BP GO:0009108 0.105940910434398 0.191096988013562 2860 2391.18181818182 2786 0.0101286660685891 788 0.86471642388145 -0.813387646022584 -1 2.35915499698572 2860 1363 3176 3068 1342 788 2663 3537 2786 2846 1874 2936 M13759 GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of a protein along a microtubule, mediated by motor proteins. 19/44 Gene Ontology BP GO:0098840 0.0296392663988458 0.085422168770851 905 2319.27272727273 2787 0.00273147963948828 179 0.592680838380628 -0.592680838380628 -1 2.40366505834785 902 2846 3217 3409 2787 179 1507 2501 3865 3830 469 2937 M14681 GO_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMETE_GENERATION.html The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. 272/1037 Gene Ontology BP GO:0007276 0.0576609283934813 0.135898320066464 4555 3118.63636363636 2787 0.00538455291276554 807 1.36610785520894 1.73621671757621 1 4.49473470871697 4555 4527 2635 4397 1031 807 4475 4489 2787 2228 2374 2938 M16836 GO_INTRACILIARY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT.html The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. 19/44 Gene Ontology BP GO:0042073 0.0296392663988458 0.085422168770851 905 2378.09090909091 2788 0.00273147963948828 180 0.592680838380628 -0.592680838380628 -1 2.40366505834785 903 2847 3218 3410 2788 180 1508 2364 3866 4605 470 2939 M16967 GO_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 12/40 Gene Ontology BP GO:0071731 0.008558987554012 0.0364916246219263 1760 2763.36363636364 2788 0.000781133487059758 558 0.481938332607101 0.626785226269458 1 2.63026336135799 1759 4206 558 3887 2966 2194 788 2788 3895 4641 2715 2940 M16166 GO_EPOXYGENASE_P450_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPOXYGENASE_P450_PATHWAY.html The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. 2/57 Gene Ontology BP GO:0019373 0.0778901246293765 0.158445571591463 2630 2934.6 2788.5 0.00896962978606159 483 0.233492323390207 -0.233492323390207 -1 0.709144773832097 2630 2694 4520 NA 2883 1951 483 2936 4373 4430 2446 2941 M15085 GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. 59/158 Gene Ontology BP GO:0043467 0.117657202188585 0.208714280799786 2790 2670.18181818182 2789 0.0113150108655272 1392 1.29059688409189 1.42054878005686 1 3.33344028388756 2789 3086 1897 3389 1392 3948 3026 1792 2285 1848 3920 2942 M10120 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. 60/144 Gene Ontology BP GO:0031333 0.0839184282471183 0.158445571591463 2095 2093.72727272727 2790 0.00793650793650794 374 1.06861757377676 1.09823757193543 1 3.24552240867577 2095 374 2873 422 3067 3416 1701 2814 687 2792 2790 2943 M15614 GO_PROTEIN_PALMITOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PALMITOYLATION.html The covalent attachment of a palmitoyl group to a protein. 12/26 Gene Ontology BP GO:0018345 0.0825579271010344 0.158445571591463 2430 2674.09090909091 2790 0.00780265788235554 535 0.321822619616896 -0.266988297731439 -1 0.977414698283298 2430 2790 2759 3026 3453 927 2498 3513 3168 4316 535 2944 M14426 GO_GROOMING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROOMING_BEHAVIOR.html The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. 6/18 Gene Ontology BP GO:0007625 0.0765897756730953 0.158445571591463 2795 2621.81818181818 2792 0.00793650793650794 120 2.10742452872238 2.10742452872238 1 6.40050631824452 2792 1554 4235 724 2667 3766 4596 4221 120 1331 2834 2945 M15951 GO_ORGANELLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_LOCALIZATION.html Any process in which an organelle is transported to, and/or maintained in, a specific location. 280/627 Gene Ontology BP GO:0051640 0.00422224247053797 0.0223024707516585 3155 2425.45454545455 2795 0.000384578876618453 52 1.14817803316819 1.30225654003536 1 7.19836233335256 3151 3876 2795 4544 899 52 2777 2496 2797 2844 449 2946 M10976 GO_ERYTHROCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_HOMEOSTASIS.html Any process of regulating the production and elimination of erythrocytes within an organism. 60/106 Gene Ontology BP GO:0034101 0.0839184282471183 0.158445571591463 2800 2467.27272727273 2796 0.00793650793650794 803 1.29210531209197 1.29210531209197 1 3.92428203289038 2796 2805 2881 1263 2503 4543 3128 1943 803 1166 3309 2947 M12512 GO_NITROGEN_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_COMPOUND_TRANSPORT.html The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 254/690 Gene Ontology BP GO:0071705 0.0378927698446008 0.100674101080254 4590 2972.09090909091 2796 0.00350560176806874 827 1.23600552036299 1.38732700348005 1 4.67798281418918 4586 4528 2447 4577 827 1118 3750 2466 2991 2796 2607 2948 M16456 GO_EMBRYONIC_PLACENTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_MORPHOGENESIS.html The process in which the embryonic placenta is generated and organized. 13/31 Gene Ontology BP GO:0060669 0.0330011899704113 0.0924152744466946 4405 2679.63636363636 2796 0.0030460798115701 775 0.497047695778532 -0.377456067602386 -1 1.95134224462347 4401 894 2148 1864 775 2796 3803 2932 2016 4506 3341 2949 M10938 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 49/136 Gene Ontology BP GO:0042993 0.398401843429907 0.519601055911533 2650 2785.18181818182 2798 0.0451460384628191 964 1.29644110978073 1.29644110978073 1 1.39920926394803 2646 1958 2798 3136 3859 964 3388 4392 2867 2740 1889 2950 M14831 GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of chromosome organization. 82/184 Gene Ontology BP GO:2001252 0.248813552496304 0.362144615749322 3910 3063.27272727273 2798 0.0256738912729275 1291 1.27358339787872 -1.13115893914357 -1 2.13250160983592 3906 4249 2133 3706 1858 1291 4604 4421 2798 2379 2351 2951 M10422 GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. 19/70 Gene Ontology BP GO:0002820 0.516837045024206 0.629835800537373 1580 2818.90909090909 2799 0.0639883827875148 1577 0.325346467891145 0.33090738394879 1 0.24794644959611 1577 4135 2316 3786 3262 2288 1901 1759 4163 3022 2799 2952 M16266 GO_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other 398/1247 Gene Ontology BP GO:0055085 0.13518801757303 0.233424308513045 2450 2629.36363636364 2799 0.0131171339772347 994 1.37544151792471 1.51889563913052 1 3.29887640025453 2447 3126 994 3449 2555 3336 2799 3197 1870 1170 3980 2953 M11776 GO_CRISTAE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRISTAE_FORMATION.html The assembly of cristae, the inwards folds of the inner mitochondrial membrane. 5/13 Gene Ontology BP GO:0042407 0.392499316922254 0.514068921994365 2800 2744.27272727273 2800 0.0486185549276602 1262 0.174170981429452 -0.198879825468634 -1 0.191050768278864 2800 4050 3803 3884 3815 1383 1464 1639 2748 3339 1262 2954 M13916 GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. 7/24 Gene Ontology BP GO:0055098 0.0853099976411005 0.160232329711824 1765 2688.54545454545 2802 0.00887736803773293 480 0.633042077535849 0.633042077535849 1 1.91092396262526 1762 2905 4156 2741 2802 1355 480 3574 4048 3874 1877 2955 M14375 GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 16/26 Gene Ontology BP GO:2001269 0.161385165508919 0.258740097879113 3455 2829.09090909091 2802 0.0158730158730159 1466 1.86280643978199 1.86280643978199 1 4.15158434088529 3453 3327 2472 2802 2708 2553 3408 3426 1466 2118 3387 2956 M16484 GO_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 61/170 Gene Ontology BP GO:0046165 0.480872455338301 0.596338357408048 2780 2981.45454545455 2802 0.0578591713286474 2002 0.986579500293883 -1.23889395501682 -1 0.840755464272079 2777 3041 2132 3513 2342 3704 2002 3697 2700 2802 4086 2957 M10129 GO_SYNAPTIC_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_LOCALIZATION.html Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. 57/155 Gene Ontology BP GO:0097479 0.295746949439039 0.413174493778819 4045 3055.27272727273 2803 0.0313716901773446 1685 1.51935086267539 -1.51935086267539 -1 2.21383636297702 4041 3456 2803 3933 1981 1685 3404 4276 2468 2782 2779 2958 M12264 GO_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CONTRACTION.html A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. 76/194 Gene Ontology BP GO:0006941 0.00556352196591884 0.0270203268700431 4295 2768.45454545455 2803 0.000507058311279136 511 1.58832511840259 -1.81544570726767 -1 9.45536680122754 4291 2803 511 2481 3206 2530 4377 3159 2193 1058 3844 2959 M15250 GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME.html The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. 8/23 Gene Ontology BP GO:0045292 0.309010561531721 0.425611402311415 1285 2631.90909090909 2803 0.0362882792646457 859 0.256130539479803 -0.286841794915909 -1 0.360684092543502 1283 3551 4375 3368 2803 859 1416 1535 4040 4221 1500 2960 M16190 GO_PROTEIN_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HYDROXYLATION.html The addition of a hydroxy group to a protein amino acid. 11/20 Gene Ontology BP GO:0018126 0.161385165508919 0.258740097879113 3605 2582.63636363636 2805 0.0158730158730159 1337 1.8636644772713 1.8636644772713 1 4.15349662491471 3601 2897 1982 1854 4177 2861 2805 2188 1337 1819 2888 2961 M15681 GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. 40/181 Gene Ontology BP GO:0007156 0.0510829940230584 0.1246965528694 2580 2408 2806 0.00475537888324221 709 1.86559754239895 -1.44346312582818 -1 6.4027057325036 2577 3173 784 1419 2851 3511 2806 4571 709 754 3333 2962 M16398 GO_APOPTOTIC_MITOCHONDRIAL_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_MITOCHONDRIAL_CHANGES.html The morphological and physiological alterations undergone by mitochondria during apoptosis. 46/85 Gene Ontology BP GO:0008637 0.0162418335734548 0.0573171082220906 3095 2560.36363636364 2807 0.00148754504842459 518 1.70043379420498 1.70043379420498 1 8.01473451226496 3093 2807 1965 2409 518 3569 3623 4212 1475 1374 3119 2963 M10718 GO_DENDRITIC_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_CHEMOTAXIS.html The movement of a dendritic cell in response to an external stimulus. 5/38 Gene Ontology BP GO:0002407 0.0765897756730953 0.158445571591463 2220 2754.54545454545 2808 0.00793650793650794 362 0.549378754210252 0.872408641912405 1 1.66853054011291 2219 4425 3624 4064 3565 2482 1320 2350 362 3081 2808 2964 M15352 GO_TROPHECTODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHECTODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. 6/14 Gene Ontology BP GO:0001829 0.437181143697204 0.555966050448129 2645 2945.63636363636 2808 0.0558589862174324 1287 0.208460776031502 -0.230975642658052 -1 0.201738849473395 2645 3451 4393 3501 2808 1776 1287 1675 4263 4250 2353 2965 M15704 GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. 148/343 Gene Ontology BP GO:0043123 0.161385165508919 0.258740097879113 2730 2949.09090909091 2808 0.0158730158730159 1616 1.38296601598544 1.38296601598544 1 3.08217747869109 2726 2659 3036 3943 3187 3717 2556 1977 1616 2808 4215 2966 M14715 GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. 10/44 Gene Ontology BP GO:0002710 0.73711614095882 0.818567386384071 1295 2757.45454545455 2809 0.114372149171226 1294 0.353804348633755 0.346063117320718 1 0.116766380755567 1294 3067 2328 3041 3241 1986 1734 2809 3968 4082 2782 2967 M12217 GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. 227/567 Gene Ontology BP GO:0044283 0.232850105696956 0.342669743502683 3860 2648.81818181818 2810 0.0238095238095238 858 1.02425356983078 1.04031023721841 1 1.80835499954074 3860 858 1570 2810 2116 1829 3747 4129 1894 2815 3509 2968 M16198 GO_ENDOTHELIAL_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 8/17 Gene Ontology BP GO:0061154 0.0765897756730953 0.158445571591463 2410 2989.27272727273 2810 0.00793650793650794 834 1.19045135446987 1.19045135446987 1 3.6155465174851 2406 2439 4527 1301 3666 4344 4518 4506 834 1531 2810 2969 M10230 GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that activates or increases the frequency, rate or extent of reproductive process. 28/84 Gene Ontology BP GO:2000243 0.104506604302729 0.18900991267086 1900 2523.09090909091 2811 0.00998440630701407 976 1.42750535851956 -1.38916827744188 -1 3.92042155960703 1898 4168 1593 3974 1332 2843 976 3730 2886 1543 2811 2970 M10858 GO_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. 467/1187 Gene Ontology BP GO:0007010 0.0859123344992806 0.160843132693613 3625 2561.09090909091 2811 0.00813300108943289 645 1.14119951876908 1.28573274639449 1 3.43770882688469 3623 3491 876 2811 1798 645 3655 3535 1624 2677 3437 2971 M16489 GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. 10/25 Gene Ontology BP GO:0072525 0.695443850093451 0.784295796935606 3665 2768.63636363636 2812 0.102445827196004 1585 1.08991325512181 1.08991325512181 1 0.436550419927838 3664 1981 2302 2812 2933 1773 1585 4623 3461 1723 3598 2972 M16318 GO_MITOTIC_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. 8/13 Gene Ontology BP GO:0007064 0.147859119791321 0.249186894080256 2515 2799.09090909091 2813 0.0158730158730159 1176 1.73041933125535 1.73041933125535 1 3.96385473966092 2511 3480 4548 2813 4314 4164 3057 1176 1503 1534 1690 2973 M16618 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM.html Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. 19/56 Gene Ontology BP GO:0010880 0.728498082020373 0.810897342842178 2230 3092.18181818182 2813 0.111771284666582 1651 1.38933387508025 1.38933387508025 1 0.480084922741804 2226 4406 2701 4360 4446 2913 1651 2458 3784 2256 2813 2974 M12377 GO_POSITIVE_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_RATE.html Any process that activates or increases the frequency or rate of heart contraction. 13/35 Gene Ontology BP GO:0010460 0.0258046320803514 0.0784616285193659 3325 2804.27272727273 2815 0.00237385179902261 695 1.70820157422404 1.70820157422404 1 7.16709711359048 3323 2309 695 2815 3364 3460 2599 3959 2503 1937 3883 2975 M16632 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 36/106 Gene Ontology BP GO:0042346 0.298735036746822 0.413174493778819 3050 2807.45454545455 2815 0.0317460317460317 1455 1.29644110978073 1.29644110978073 1 1.88903599672661 3046 2289 2815 2978 2859 1455 4208 4081 2073 2631 2447 2976 M14107 GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 10/45 Gene Ontology BP GO:0050996 0.012878463584291 0.0488518843315876 3565 2706.18181818182 2816 0.00117767962043242 457 0.858982002181133 0.858982002181133 1 4.27497225420313 3565 1912 2171 2448 457 3399 4593 894 2816 3924 3589 2977 M15481 GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 44/104 Gene Ontology BP GO:0046916 0.415320710913563 0.535202348257472 2725 3108.09090909091 2816 0.0476190476190476 1854 1.21831602395311 -0.930896232997513 -1 1.25547540975137 2725 3833 2738 3942 4163 2816 1854 3600 2450 2171 3897 2978 M10682 GO_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CYCLE.html The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. 47/143 Gene Ontology BP GO:0042633 0.0115031551664355 0.0448439541878759 3170 2324.36363636364 2817 0.00105124961770019 586 1.15678433711544 1.18200258610613 1 5.92031628482393 1497 3170 586 2833 3170 2817 2881 2874 2133 1440 2167 2979 M11145 GO_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_MORPHOGENESIS.html The process in which the anatomical structures of the lung are generated and organized. 24/70 Gene Ontology BP GO:0060425 0.466738071388703 0.580826820010117 2820 3212.54545454545 2818 0.0555555555555556 2433 0.389727035573721 -0.269175221394943 -1 0.349055021912947 2818 2810 2433 2797 4184 4546 2491 3795 2529 3180 3755 2980 M13884 GO_MOLTING_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLTING_CYCLE.html The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. 47/143 Gene Ontology BP GO:0042303 0.0115031551664355 0.0448439541878759 3175 2325.90909090909 2818 0.00105124961770019 587 1.15678433711544 1.18200258610613 1 5.92031628482393 1498 3171 587 2834 3171 2818 2882 2880 2134 1442 2168 2981 M11202 GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/16 Gene Ontology BP GO:0032375 0.572588314655059 0.680626611608663 1715 2909.36363636364 2819 0.0814884132942547 1711 0.424402440132221 0.588602537597934 1 0.269177251916145 1711 2798 3708 3532 2577 3604 1808 2684 3573 3189 2819 2982 M12474 GO_REGULATION_OF_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_PLASTICITY.html A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 73/229 Gene Ontology BP GO:0048167 0.0317303546268706 0.0896677033064883 2475 2868.63636363636 2819 0.00292704158401416 758 1.29433115515881 -1.28452471131921 -1 5.14576867840602 2475 3232 2292 4044 758 3869 2819 3343 2604 2216 3903 2983 M12628 GO_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CONTRACTION.html A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. 128/347 Gene Ontology BP GO:0006936 0.00146209665136913 0.0101776832868169 3630 2888.90909090909 2819 0.000133006295485208 404 1.62832351541182 -1.81544570726767 -1 12.3144152093096 3629 2590 404 2819 3043 2338 4530 4483 2049 1658 4235 2984 M14035 GO_MITOTIC_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_CHECKPOINT.html A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. 88/191 Gene Ontology BP GO:0007093 0.702674025738705 0.789000121282904 2140 2865.18181818182 2819 0.104404140006127 1483 1.19543171804843 -1.00026403401684 -1 0.467029320582378 2139 4388 2842 3716 3362 1483 2721 2819 3449 2455 2143 2985 M15761 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 94/249 Gene Ontology BP GO:0007163 0.0839184282471183 0.158445571591463 4635 2844.72727272727 2819 0.00793650793650794 1058 1.59050962381889 1.76567967750125 1 4.83057246304411 4634 3618 1969 3395 2819 1474 4054 3522 1058 2092 2657 2986 M15259 GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/16 Gene Ontology BP GO:0032372 0.572588314655059 0.680626611608663 1715 3064.45454545455 2820 0.0814884132942547 1712 0.424402440132221 0.588602537597934 1 0.269177251916145 1712 2799 4377 3533 2578 3605 1809 2678 3574 4224 2820 2987 M14441 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION.html The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. 14/26 Gene Ontology BP GO:0015949 0.287816575181527 0.406314497069646 1775 2825.81818181818 2821 0.0303851457273296 1773 0.294531047380891 -0.35100860104018 -1 0.437288413557819 1773 3146 2802 3326 1957 1924 2984 2821 4140 4018 2193 2988 M11443 GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. 17/34 Gene Ontology BP GO:1901889 0.35943518917414 0.479556776820555 2995 2866.81818181818 2822 0.0396825396825397 1597 1.19045135446987 1.19045135446987 1 1.44220599524924 2991 4039 1640 2272 3936 4181 2822 1597 2223 2144 3690 2989 M16192 GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of a response to tumor cell. 3/16 Gene Ontology BP GO:0002834 0.125146209764154 0.218770275577925 3655 3032.81818181818 2822 0.0132808708856476 1481 0.357174958066226 -0.202967096716133 -1 0.894828604720308 3652 2150 4526 2517 1481 2806 2200 2822 2916 4438 3853 2990 M15344 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. 7/31 Gene Ontology BP GO:0035235 0.386086746459241 0.506813899861537 2805 3092 2823 0.0476190476190476 1425 1.38933387508025 1.38933387508025 1 1.55653476545824 2805 1947 4392 2313 3667 3828 4259 4209 2344 1425 2823 2991 M11344 GO_THYROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. 3/17 Gene Ontology BP GO:0042403 0.108025556414129 0.194253547029746 2450 2639.63636363636 2825 0.0113666852407985 962 0.435188045778116 -0.604855178474138 -1 1.17554449630846 2446 3581 3733 3354 2828 2383 2272 962 2825 3231 1421 2992 M16451 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 14/48 Gene Ontology BP GO:0032786 0.597508783978256 0.701449629332754 2050 3088.72727272727 2825 0.0794046768303806 1280 0.164097470106167 -0.183689356370773 -1 0.0959267509086089 2048 4560 3228 4546 2825 1280 2057 2686 4525 4503 1718 2993 M12849 GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. 2/14 Gene Ontology BP GO:0072283 0.610907176174845 0.713211470701484 2865 2937.2 2826 0.0995691670373566 1567 0.20291267832574 -0.20291267832574 -1 0.113054608309923 2861 3584 3968 NA 2791 1903 1567 2183 4220 3587 2708 2994 M14073 GO_ACTIN_MEDIATED_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MEDIATED_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. 54/134 Gene Ontology BP GO:0070252 0.000140013020345979 0.00185577702597249 3715 2507 2826 1.27292665352838e-05 271 2.05496179896089 -2.2038900244525 -1 21.3063024507023 3711 2878 271 2782 3301 1967 3182 2826 2194 1047 3418 2995 M16790 GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of organelle assembly. 28/66 Gene Ontology BP GO:1902117 0.597318307603006 0.701403364238937 3935 2978.54545454545 2826 0.0793650793650794 1721 0.719176432797489 -0.634365601342 -1 0.420488449659641 3935 2419 2527 1721 3585 2051 2555 2906 2826 4593 3646 2996 M13637 GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. 68/218 Gene Ontology BP GO:0002706 0.130799994665328 0.226944833793392 2020 2691.90909090909 2827 0.0126629617734998 1461 1.11882204112119 1.11882204112119 1 2.73531820116387 2018 3417 2105 3597 1461 3031 1711 2707 3135 2827 3602 2997 M14733 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 45/93 Gene Ontology BP GO:0090003 0.127572579865982 0.222295475097511 3300 2934.81818181818 2827 0.0123302440521786 1443 1.27686276702898 1.15561871920577 1 3.16527009310613 3296 2773 1884 1584 1443 4015 3540 4183 2827 2183 4555 2998 M14074 GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 166/421 Gene Ontology BP GO:0045089 0.270662292071023 0.388345186058641 3980 3107.45454545455 2830 0.0282848590776952 1909 1.23876771215669 1.23876771215669 1 1.93156172714354 3979 3415 2593 4032 1909 2815 3141 2830 2804 2754 3910 2999 M10060 GO_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSPORT.html The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/175 Gene Ontology BP GO:0006813 0.322645543068026 0.441640110986099 3100 2917.54545454545 2831 0.0347948384018634 654 1.34638126193026 1.40962546558766 1 1.81392706843206 3096 2342 1261 2719 3850 4359 2831 4520 2406 654 4055 3000 M16070 GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS.html The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. 25/57 Gene Ontology BP GO:0006921 0.503734536406241 0.620217303774643 2835 3088.45454545455 2832 0.061708804456185 1377 0.320225461193278 -0.323843477681956 -1 0.252167634484057 2832 3564 2529 4311 2387 1377 3609 2417 4228 4414 2305 3001 M16073 GO_POSITIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 198/563 Gene Ontology BP GO:0051047 0.0639108608458069 0.145817261379401 1845 2765 2832 0.00598606378001716 830 1.2781755150504 1.55063730082268 1 4.05698354596159 1843 3702 830 3714 2765 4563 2691 1595 2904 2832 2976 3002 M16327 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. 15/37 Gene Ontology BP GO:0000083 0.794572123110519 0.869888792172162 1410 2820.09090909091 2832 0.13400678595515 1408 1.28983715113895 1.28983715113895 1 0.296386031838697 1408 3889 1876 2792 4564 3043 1795 3342 3394 2086 2832 3003 M14122 GO_PROTEIN_K48_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. 13/28 Gene Ontology BP GO:0071108 0.597318307603006 0.701403364238937 3990 2938.90909090909 2834 0.0793650793650794 1712 1.48034281358945 1.48034281358945 1 0.865527604073998 3988 2787 2196 3066 2574 4391 1712 2834 2869 1950 3961 3004 M11861 GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 29/115 Gene Ontology BP GO:0033555 0.0156153190677066 0.0557278450663812 2695 2742.63636363636 2835 0.00142975169509978 626 1.98294428544816 1.98294428544816 1 9.43822348912126 2692 3837 626 3369 2356 3759 2835 3786 2038 1564 3307 3005 M12427 GO_LEYDIG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEYDIG_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. 3/13 Gene Ontology BP GO:0033327 0.275742742869669 0.392721949430635 2490 2987.54545454545 2835 0.0317460317460317 1917 0.305778466260031 -0.0366791255141523 -1 0.471138985135439 2488 3698 3906 2790 2775 2835 2978 3287 1917 3484 2705 3006 M16044 GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 9/17 Gene Ontology BP GO:0060547 0.023303595675479 0.0730084984623812 3110 2708.81818181818 2835 0.0023551640378142 668 0.889829409089437 -0.889829409089437 -1 3.83912095664086 3109 1451 4499 1751 668 1989 3311 4619 2835 4407 1158 3007 M13277 GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. 17/50 Gene Ontology BP GO:0071825 0.415320710913563 0.535202348257472 3505 2864.27272727273 2836 0.0476190476190476 1033 0.457746532287446 0.412952623528511 1 0.47170808210054 3502 1033 1905 2074 2836 3924 3399 2648 2348 3693 4145 3008 M10239 GO_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of mRNA metabolic process. 72/183 Gene Ontology BP GO:1903311 0.12747145836387 0.222249335780492 1975 2854.45454545455 2837 0.0123198374154311 436 1.84601786585865 1.84601786585865 1 4.5768048778627 1975 4496 3249 4559 2837 436 2338 4058 3441 2633 1377 3009 M10726 GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 10/24 Gene Ontology BP GO:0070168 0.35943518917414 0.479556776820555 4060 3061.90909090909 2838 0.0396825396825397 1675 1.45023161899474 1.45023161899474 1 1.75692415116918 4058 2755 2143 2838 2128 3699 3933 3990 2174 1675 4288 3010 M10698 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 8/14 Gene Ontology BP GO:0034244 0.316872793390825 0.434840576364355 2705 2848.63636363636 2840 0.0373904672052797 1118 0.247500222143339 -0.316905071662823 -1 0.339777983650144 2702 3442 3621 3546 2376 1506 2840 2745 4362 3077 1118 3011 M12198 GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 18/38 Gene Ontology BP GO:0044275 0.161385165508919 0.258740097879113 4125 2858.18181818182 2840 0.0158730158730159 1349 1.70956702222945 1.70956702222945 1 3.81006395918689 4122 1651 2840 2073 3185 2431 4577 3434 1349 2192 3586 3012 M16351 GO_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_KILLING.html Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. 45/138 Gene Ontology BP GO:0031341 0.183165073942152 0.286728064165008 2790 2949.63636363636 2840 0.0182244574477576 1667 0.380101549610745 0.473272664869432 1 0.782763320927472 2786 2840 1912 3235 1667 3593 1961 2413 3615 4478 3946 3013 M15269 GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html A process in which a protein is transported to, or maintained in, a location within the mitochondrion. 44/92 Gene Ontology BP GO:0070585 0.204037871627363 0.312140968028286 2425 2917.18181818182 2841 0.0205320749046893 1397 0.246309920327975 -0.270757380696813 -1 0.472757559902106 2423 2841 3425 3755 1730 1397 2757 3505 3793 4225 2238 3014 M13861 GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. 3/16 Gene Ontology BP GO:0002837 0.125146209764154 0.218770275577925 3650 2946.36363636364 2846 0.0132808708856476 1479 0.357174958066226 -0.202967096716133 -1 0.894828604720308 3650 2148 4147 2515 1479 2804 2198 2846 2914 3858 3851 3015 M16453 GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the N-terminal amino acid residue in a protein. 10/27 Gene Ontology BP GO:0031365 0.281410755911607 0.399080677977273 2170 3060.09090909091 2846 0.0295955218062542 1939 0.215485662135281 -0.257471530283909 -1 0.326311537306763 2666 2225 3359 2846 1939 2167 4063 4177 3546 4504 2169 3016 M11045 GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. 11/21 Gene Ontology BP GO:0003323 0.232850105696956 0.342669743502683 2755 2948.63636363636 2847 0.0238095238095238 1691 1.46584243959724 1.46584243959724 1 2.58799537764924 3299 2754 2032 2918 2755 4384 2847 4249 1691 1778 3728 3017 M13866 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. 3/14 Gene Ontology BP GO:0002836 0.125146209764154 0.218770275577925 3655 2947.54545454545 2847 0.0132808708856476 1480 0.357174958066226 -0.202967096716133 -1 0.894828604720308 3651 2149 4149 2516 1480 2805 2199 2847 2915 3860 3852 3018 M16873 GO_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_FUSION.html A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 11/49 Gene Ontology BP GO:0007520 0.417247670086248 0.537081696819155 2850 2976.72727272727 2848 0.0479048226636257 1321 0.416591794837658 -0.370857782715338 -1 0.426890800079162 2848 3295 1321 3732 3452 1777 1769 2784 4402 4615 2749 3019 M15970 GO_RESPONSE_TO_COBALT_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COBALT_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. 9/17 Gene Ontology BP GO:0032025 0.046214469762918 0.115860574033061 4595 2801.27272727273 2849 0.00472046779352038 238 1.86280643978199 1.86280643978199 1 6.61882128954398 4593 1501 4489 1224 974 2849 4438 4419 238 1628 4461 3020 M15994 GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 87/233 Gene Ontology BP GO:0043902 0.16156904046766 0.258857421392354 735 2646.90909090909 2851 0.0158926341919244 731 0.303098152222158 0.317742166699125 1 0.675279814937462 1592 3704 2851 4291 3643 1754 733 1312 4107 4398 731 3021 M15852 GO_POSITIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AUTOPHAGY.html Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 56/126 Gene Ontology BP GO:0010508 0.433580963566995 0.552750250917506 2245 2797.81818181818 2852 0.0503622168305103 1612 1.07753641947021 1.07753641947021 1 1.05309510858629 2242 2484 3059 3297 3577 3846 2182 1612 2852 2435 3190 3022 M10532 GO_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASODILATION.html Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels. 20/71 Gene Ontology BP GO:0042312 0.00638979803271608 0.0296678322659007 2230 2571.45454545455 2854 0.000582584792921457 528 0.858982002181133 0.858982002181133 1 4.98119342949112 2230 2597 528 2299 1921 3567 3144 3172 2854 3042 2932 3023 M15280 GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. 899/2144 Gene Ontology BP GO:0071822 0.0484047096360078 0.1197141052193 3525 2684.72727272727 2854 0.00494925684101438 959 1.14565802364439 1.31855324246885 1 4.00889512606009 3522 2588 4379 3018 994 959 3677 3650 1623 2854 2268 3024 M13412 GO_CARDIOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. 5/19 Gene Ontology BP GO:0010002 0.0765897756730953 0.158445571591463 2855 2413.63636363636 2855 0.00793650793650794 63 1.07272638267715 -1.07272638267715 -1 3.25800136437252 2855 910 4071 792 3302 3740 2635 3298 63 1197 3687 3025 M15201 GO_MATURE_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION.html The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. 8/24 Gene Ontology BP GO:0002335 0.386086746459241 0.506813899861537 4010 3402.36363636364 2855 0.0476190476190476 2352 0.398616690131783 -0.350631386805264 -1 0.446588647434283 4009 2828 4368 2805 2855 3968 2710 2783 2352 4207 4541 3026 M11041 GO_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane. 83/181 Gene Ontology BP GO:0061025 0.0461943225830583 0.115860574033061 1750 2319 2856 0.0042903446727313 290 1.45023161899474 1.45023161899474 1 5.15288314958939 1750 2914 3166 3420 933 290 2360 3486 3165 2856 1169 3027 M16572 GO_LYSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. 6/16 Gene Ontology BP GO:0006553 0.00865515088202925 0.0366767722932968 3410 2667.36363636364 2856 0.000868904707188031 371 0.577018634726521 0.577018634726521 1 3.14436685176734 3406 841 4583 1730 371 2182 2099 3494 3245 4534 2856 3028 M11908 GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). 13/31 Gene Ontology BP GO:1901071 0.0839184282471183 0.158445571591463 4480 2827.27272727273 2858 0.00793650793650794 228 3.21934379747048 3.21934379747048 1 9.77754127641277 4476 2789 1320 1729 4161 3898 3365 2858 228 1935 4341 3029 M12794 GO_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. 146/316 Gene Ontology BP GO:0019882 0.308493243872185 0.425024964777019 2495 2837.72727272727 2858 0.0329787028087117 809 0.944322470076944 1.10165111781873 1 1.33194528107439 2495 4315 2858 4542 2276 809 2938 2561 3656 2910 1855 3030 M14401 GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. 26/71 Gene Ontology BP GO:0042304 0.237138895990027 0.347878639520283 2345 3001.63636363636 2858 0.0243069201741609 1827 0.692037644314168 -0.649810243057386 -1 1.2046051295541 2345 3500 2606 3254 1827 4006 2193 2462 3964 4003 2858 3031 M14755 GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic hydroxy compound. 83/247 Gene Ontology BP GO:1901617 0.35943518917414 0.479556776820555 3205 2912.36363636364 2858 0.0396825396825397 1214 0.826023931707886 -0.871903374776353 -1 1.00071007688885 3204 1214 1469 2982 2171 4210 2665 4436 2320 2858 4507 3032 M12896 GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. 122/332 Gene Ontology BP GO:0043903 0.597318307603006 0.701403364238937 3175 2917.36363636364 2859 0.0793650793650794 1677 1.24139065779204 1.49470451002596 1 0.725816933654054 3175 1677 1923 3161 4545 3517 2050 2141 2859 2839 4204 3033 M14734 GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 9/18 Gene Ontology BP GO:0009219 0.322973812244201 0.441959154214508 1655 2823.36363636364 2860 0.0382536499554013 889 0.261267527078203 -0.268564927995286 -1 0.351684540453871 1651 3666 4284 3829 2860 889 1873 2424 4043 4087 1451 3034 M16840 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. 31/108 Gene Ontology BP GO:0046635 0.414108039109092 0.535202348257472 2230 2873.54545454545 2860 0.0474396426385447 1119 0.343123796219453 -0.298073958197608 -1 0.353589282279513 2229 3420 2161 3703 2227 1119 2860 3350 3803 4607 2130 3035 M11027 GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION.html The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 9/25 Gene Ontology BP GO:0021694 0.0497316826904594 0.122042390450213 2100 2522.72727272727 2861 0.00508810103672973 674 1.17287447352151 -1.03069309216194 -1 4.06688814182741 2098 3960 3672 3728 3188 1390 3375 712 2861 674 2092 3036 M15937 GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. 14/21 Gene Ontology BP GO:0043162 0.138840394437332 0.2387540560639 3540 2892.45454545455 2861 0.0134967652347609 912 0.259619154345837 -0.349245077875166 -1 0.613011648228068 3536 4143 2861 4253 1873 912 2832 1022 4424 4385 1576 3037 M10303 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. 87/145 Gene Ontology BP GO:0043624 0.699506804462538 0.786204331425699 1225 2939.27272727273 2862 0.103541019947877 1224 0.751302067173766 0.751302067173766 1 0.297913940977714 1224 4031 3486 4298 2862 1479 2783 2465 4226 2998 2480 3038 M13019 GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION.html The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. 9/25 Gene Ontology BP GO:0021702 0.0444732767610119 0.112959203501848 2100 2550.36363636364 2862 0.00453892260294 677 1.17287447352151 -1.03069309216194 -1 4.21642798754989 2099 3961 3994 3729 3189 1391 3376 683 2862 677 2093 3039 M15090 GO_REGULATION_OF_CHOLESTEROL_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_STORAGE.html Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 9/23 Gene Ontology BP GO:0010885 0.214139132665174 0.322775948981753 1785 2683.81818181818 2864 0.0238095238095238 1619 1.69748649654937 1.69748649654937 1 3.16433504916103 1782 2864 4348 2444 3369 2892 2447 2927 1828 1619 3002 3040 M16972 GO_AMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 9/24 Gene Ontology BP GO:0009309 0.639318073475759 0.736417159663516 4645 3040.45454545455 2865 0.096948666905144 1723 0.801128877993451 0.801128877993451 1 0.404069892028609 1723 2865 4643 3877 3230 2074 1840 2351 4437 4643 1762 3041 M12835 GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. 12/27 Gene Ontology BP GO:2000369 0.35943518917414 0.479556776820555 3290 3007.63636363636 2866 0.0396825396825397 1872 1.26395308557773 -1.26395308557773 -1 1.53125174825706 3288 3850 2357 2485 3769 3367 2866 2637 2151 1872 4442 3042 M13110 GO_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_PRODUCTION.html The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. 8/36 Gene Ontology BP GO:0032609 0.422375943166009 0.541289402185973 1720 2733.18181818182 2867 0.0534043001599965 1221 0.362135529674028 -0.326037395539053 -1 0.366429486710834 1718 2867 4015 2504 3916 1221 1847 3273 3733 3651 1320 3043 M15755 GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. 10/24 Gene Ontology BP GO:1904666 0.35943518917414 0.479556776820555 4320 2996.27272727273 2868 0.0396825396825397 1801 0.299601415593576 -0.287347232029414 -1 0.362960616554556 4318 1801 3191 2395 2560 2868 3339 2598 2271 4346 3272 3044 M16283 GO_MYELOID_DENDRITIC_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_ACTIVATION.html The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 14/33 Gene Ontology BP GO:0001773 0.187241824780231 0.291830746040488 4290 2793.54545454545 2869 0.018670921657975 817 0.653874098340854 0.653874098340854 1 1.32754348604392 4289 817 2684 1503 1684 2869 3382 3363 1984 4460 3694 3045 M11501 GO_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of the process of creating protein polymers. 92/225 Gene Ontology BP GO:0032271 0.0839184282471183 0.158445571591463 3685 2583.81818181818 2870 0.00793650793650794 931 0.873590001858948 -0.789659415677694 -1 2.65319979435985 3683 931 2552 1042 2142 3103 3097 3585 1186 2870 4231 3046 M10362 GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. 93/198 Gene Ontology BP GO:0032434 0.278088287534392 0.395456024202812 4075 2857 2872 0.0291884891599834 752 0.855175050749486 -0.583871951991638 -1 1.30786062613851 4073 2836 3049 2740 3039 752 3567 4273 2571 2872 1655 3047 M10920 GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. 11/30 Gene Ontology BP GO:0044065 0.466738071388703 0.580826820010117 3660 2783.63636363636 2872 0.0555555555555556 1607 1.38933387508025 1.38933387508025 1 1.24434263502787 3660 3576 2689 3140 2872 2099 1607 3458 2533 1776 3210 3048 M11349 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. 16/41 Gene Ontology BP GO:0030835 0.0839184282471183 0.158445571591463 2875 2365.36363636364 2872 0.00793650793650794 338 0.918246869629757 0.897743299739423 1 2.78882816938937 2872 409 1444 388 3761 3440 2771 4102 338 3233 3261 3049 M12817 GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. 121/342 Gene Ontology BP GO:0050714 0.0616645691058204 0.141877400573996 2850 2797.72727272727 2873 0.0057694552782873 819 1.20529577621661 1.33493065785597 1 3.88008426753163 2847 2873 819 3348 1969 3198 3932 1994 2898 2712 4185 3050 M13778 GO_ADRENAL_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENAL_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. 13/28 Gene Ontology BP GO:0030325 0.100355348406207 0.182868870741765 2890 2553.81818181818 2873 0.00956806157156306 913 1.38916827744188 -1.38916827744188 -1 3.89077559995259 2888 3293 913 3404 2873 2300 3323 2992 2545 1948 1613 3051 M14484 GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 120/307 Gene Ontology BP GO:0051494 0.515625808022267 0.628854905870078 3400 2662.36363636364 2874 0.0637753091673927 1306 0.843338228507913 -0.758283505231832 -1 0.644874661233325 3397 2874 1597 2243 4303 1306 3746 1756 3296 2897 1871 3052 M10356 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. 95/205 Gene Ontology BP GO:1903321 0.0247163782247427 0.0759987709254837 775 2382.72727272727 2875 0.00227259157716717 160 1.48034281358945 1.48034281358945 1 6.28889991683559 774 4248 3365 4111 3295 160 1332 1919 3681 2875 450 3053 M10776 GO_GLUCOCORTICOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. 4/24 Gene Ontology BP GO:0008211 0.00519020489631493 0.0256909609100109 3635 2248.72727272727 2875 0.000520236709620661 115 0.322747083590504 0.322747083590504 1 1.94816920322927 1011 2278 3631 3071 2875 549 115 3999 3634 3089 484 3054 M11104 GO_ATP_GENERATION_FROM_ADP http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_GENERATION_FROM_ADP.html The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. 19/54 Gene Ontology BP GO:0006757 0.232850105696956 0.342669743502683 2890 2324.27272727273 2876 0.0238095238095238 958 1.50049685841841 1.50049685841841 1 2.64917894916261 2890 958 1467 1550 2876 3556 2898 3000 1743 1118 3511 3055 M12429 GO_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 58/151 Gene Ontology BP GO:0009308 0.0527137755778039 0.127248621554242 4160 2761.18181818182 2876 0.0049109912867744 789 1.13923770544315 -1.0248491474855 -1 3.87180006080528 4157 1272 789 1847 1581 3721 3709 4573 2876 1828 4020 3056 M13466 GO_BASIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASIC_AMINO_ACID_TRANSPORT.html The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/14 Gene Ontology BP GO:0015802 0.349001822621778 0.472149027515418 2880 2868.09090909091 2876 0.0420166141041869 1520 0.432431216986165 -0.675018666628729 -1 0.534978686873766 2876 3198 4080 3813 2746 1921 2044 1520 3323 3746 2282 3057 M12118 GO_LEFT_RIGHT_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_PATTERN_FORMATION.html The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 14/39 Gene Ontology BP GO:0060972 0.179763977871223 0.282285163146815 4535 2812 2877 0.0178535346135201 1323 0.896585420808603 0.896585420808603 1 1.86946762608995 4534 2118 1323 2958 1654 1919 2877 3560 2515 3416 4058 3058 M16675 GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 95/214 Gene Ontology BP GO:0035966 0.00277246357407173 0.016461059302321 3385 2569.09090909091 2877 0.000252360330825632 42 0.859189599570179 0.968763228229394 1 5.81673979901888 2347 3937 3383 3386 3470 42 2389 2807 3382 2877 240 3059 M11425 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE.html Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. 8/29 Gene Ontology BP GO:0042749 0.562604368603265 0.670992058418947 2320 2876.09090909091 2878 0.0793650793650794 2083 0.475177724513927 0.555347542984145 1 0.312549141208842 2317 2362 3744 2966 3544 2834 2398 2083 2878 3247 3264 3060 M12918 GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. 41/90 Gene Ontology BP GO:0006368 0.34836513977331 0.471548427771505 1655 2857.27272727273 2878 0.0381855425276543 886 0.198445232958934 -0.22562123815667 -1 0.245921274653711 1653 4319 3472 4536 2878 886 2730 1962 3885 3602 1507 3061 M14828 GO_MEMBRANE_HYPERPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_HYPERPOLARIZATION.html The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. 8/21 Gene Ontology BP GO:0060081 0.275742742869669 0.392721949430635 1990 2913.54545454545 2878 0.0317460317460317 1521 1.38933387508025 1.38933387508025 1 2.14066529967705 1987 3441 4299 3680 3211 2407 2878 4130 1967 1521 2528 3062 M11721 GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 33/133 Gene Ontology BP GO:0045913 0.292874297937129 0.411317412378128 1720 2586.63636363636 2879 0.0310131690145424 1012 0.379699147351184 0.36549340255891 1 0.556076906551534 1719 3278 2381 3799 2879 3564 1012 1387 3267 3326 1841 3063 M12909 GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 45/133 Gene Ontology BP GO:0048259 0.35943518917414 0.479556776820555 2365 3180.54545454545 2880 0.0396825396825397 1973 1.20533937591405 -1.26395308557773 -1 1.46024251031238 2361 4449 2304 4391 4453 4002 2880 1973 2277 2180 3716 3064 M10958 GO_TRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. 103/180 Gene Ontology BP GO:0006399 0.466738071388703 0.580826820010117 1490 2962.45454545455 2881 0.0555555555555556 1488 1.10127572444747 -0.687595811501009 -1 0.986346306945888 1488 4082 3490 4193 2437 1911 3445 3546 2580 2881 2534 3065 M11247 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. 3/14 Gene Ontology BP GO:0002839 0.125146209764154 0.218770275577925 3650 2849.63636363636 2881 0.0132808708856476 1478 0.357174958066226 -0.202967096716133 -1 0.894828604720308 3649 2147 3716 2514 1478 2803 2197 2881 2913 3198 3850 3066 M16342 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM.html Any process that modulates the frequency, rate or extent of defense response to bacterium. 7/15 Gene Ontology BP GO:1900424 0.632427457617131 0.731410454716618 2620 2807.09090909091 2881 0.0952380952380952 1190 0.429823032982352 0.455637715574838 1 0.221626081119446 2619 1190 4551 1541 3297 1648 2047 3625 3002 4477 2881 3067 M12160 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). 326/904 Gene Ontology BP GO:0006366 0.0286212661586627 0.0833679666089529 4025 2962.54545454545 2882 0.00263641323206053 719 1.20169874536295 1.38456828537923 1 4.92180725252243 4025 3731 3236 3992 719 1232 4545 2857 2577 2882 2792 3068 M16571 GO_COFACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. 105/181 Gene Ontology BP GO:0051188 0.0910652945450137 0.168856294957068 2970 2461.81818181818 2883 0.00864261947938781 699 0.86471642388145 -0.813387646022584 -1 2.53553567663159 2969 1419 3366 3874 1272 699 2460 3309 2906 2883 1923 3069 M11010 GO_NEGATIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RNA_SPLICING.html Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. 18/50 Gene Ontology BP GO:0033119 0.26237198239196 0.3783208429335 2395 2586.72727272727 2885 0.0272858835853227 877 0.26805056954578 -0.311932635398205 -1 0.429516838846023 2393 3006 3264 3248 2512 877 2885 2208 3965 3140 956 3070 M15005 GO_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 290/763 Gene Ontology BP GO:0043900 0.63389956273523 0.731410454716618 2435 2925.27272727273 2885 0.0873015873015873 2063 1.17986304132936 1.37603883214024 1 0.608362982378713 2434 2910 2439 3882 2842 3780 2063 2226 2980 2885 3737 3071 M13592 GO_HEART_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_FORMATION.html The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. 8/18 Gene Ontology BP GO:0060914 0.0437638389245526 0.112015162142612 3745 2557.18181818182 2886 0.00446503854556134 728 1.38975139692581 -1.38975139692581 -1 5.01531755879946 3742 1052 4100 728 950 3923 4464 3323 1443 1518 2886 3072 M14931 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. 20/60 Gene Ontology BP GO:0035088 0.0839184282471183 0.158445571591463 3245 2568.63636363636 2886 0.00793650793650794 112 1.916258222389 1.916258222389 1 5.81991084026652 3241 2300 1847 1218 4557 4349 2886 3183 112 637 3925 3073 M15632 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. 20/60 Gene Ontology BP GO:0061245 0.0839184282471183 0.158445571591463 3245 2567.36363636364 2887 0.00793650793650794 113 1.916258222389 1.916258222389 1 5.81991084026652 3242 2301 1848 1219 4558 4350 2887 3158 113 639 3926 3074 M16900 GO_QUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving quinone. 20/46 Gene Ontology BP GO:1901661 0.0209730346668891 0.0680135015242823 2890 2669 2888 0.0019250622388836 598 0.282617406170149 -0.259481575989773 -1 1.25235552578997 2627 2888 3204 3766 598 1863 3468 1455 2890 4626 1974 3075 M12178 GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 13/29 Gene Ontology BP GO:0034243 0.462891149117535 0.580826820010117 2890 2874.81818181818 2889 0.0549381981417444 1346 0.221220348386233 -0.279368121237082 -1 0.198133735859658 2889 3476 3169 3702 2800 1481 2457 2526 4349 3428 1346 3076 M12337 GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS.html The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. 113/269 Gene Ontology BP GO:0015980 0.360259438202237 0.480380405391438 2515 2862.45454545455 2889 0.0397949410653143 932 1.13694453389084 -0.564322045552235 -1 1.37416739478968 2513 3588 3462 3748 2118 932 2756 4054 3120 2889 2307 3077 M13872 GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 113/242 Gene Ontology BP GO:0061136 0.119453723006252 0.210963726100429 2890 2798.18181818182 2890 0.0114981842775221 419 0.855175050749486 -0.583871951991638 -1 2.19369091175056 3792 3650 3214 2888 3655 419 2688 3639 2883 2890 1062 3078 M15038 GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. 22/69 Gene Ontology BP GO:0048483 0.640681985004712 0.737041574967992 2360 2798.63636363636 2892 0.0888518467685051 1345 0.792904243146179 -0.792904243146179 -1 0.398813744440737 2359 3242 1795 3402 2958 1345 2753 2892 4113 4165 1761 3079 M16160 GO_PROTEIN_INSERTION_INTO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_INSERTION_INTO_MEMBRANE.html The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. 11/30 Gene Ontology BP GO:0051205 0.816521443770307 0.888471774882948 3610 2921.45454545455 2892 0.142857142857143 1818 1.21455215107271 1.21455215107271 1 0.236765091037739 2081 3606 2892 3606 3659 3535 2610 2329 3322 1818 2678 3080 M10440 GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. 16/29 Gene Ontology BP GO:0045648 0.42128322884786 0.540635166263299 3680 2773.90909090909 2894 0.0485061047508416 1298 0.849254971022537 0.849254971022537 1 0.861018016092699 3676 2170 2067 1913 2235 1298 3526 4239 3464 3031 2894 3081 M16957 GO_DETECTION_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CALCIUM_ION.html The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. 6/20 Gene Ontology BP GO:0005513 0.147859119791321 0.249186894080256 4640 2905.63636363636 2894 0.0158730158730159 1343 0.371138138340667 -0.423709990432594 -1 0.850162525301206 2894 1555 4640 1570 2918 2657 4536 2219 1343 4638 2992 3082 M13106 GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION.html Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. 12/20 Gene Ontology BP GO:0000394 0.161385165508919 0.258740097879113 4220 2872.81818181818 2895 0.0158730158730159 1244 1.48631403278706 -0.636526882135267 -1 3.31250629819187 4218 2895 2862 2722 3056 2984 3860 2060 1244 1874 3826 3083 M14926 GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of keratinocyte differentiation. 20/44 Gene Ontology BP GO:0045616 0.83885607293166 0.907035106339473 3960 3051.09090909091 2895 0.152911978941381 1786 1.33403223803043 -1.33403223803043 -1 0.214581623156367 3956 1786 1798 2529 4333 2535 4303 3548 3579 2300 2895 3084 M11514 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION.html A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. 14/25 Gene Ontology BP GO:0000132 0.466738071388703 0.580826820010117 2790 3004.45454545455 2896 0.0555555555555556 2562 0.889829409089437 -0.889829409089437 -1 0.796966583341461 3211 2786 2935 2913 2896 2788 4215 2613 2562 3277 2853 3085 M12130 GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS.html Any process that modulates the frequency, rate or extent of removal of superoxide radicals. 4/10 Gene Ontology BP GO:2000121 0.0912026823912704 0.169043534667732 3195 2504.09090909091 2896 0.00951773515568993 676 0.653000061178907 -0.351981970556849 -1 1.91354447446706 3192 676 3855 1653 4103 2896 2010 900 1375 3419 3466 3086 M14664 GO_CELLULAR_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 46/139 Gene Ontology BP GO:1901655 0.00228952600872968 0.0144041588868996 3580 2474.09090909091 2897 0.000208355652835922 383 1.13331137514663 -0.816391131298516 -1 7.92193099218711 3577 383 430 926 459 4199 3466 2897 3537 2719 4622 3087 M15648 GO_MACROMITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMITOPHAGY.html Degradation of a mitochondrion by macroautophagy. 84/198 Gene Ontology BP GO:0000423 0.372692467602242 0.493416346471973 4275 2908.54545454545 2897 0.04150657832347 922 1.0643284287678 1.18536382612266 1 1.23942168782359 4275 3131 2074 3929 3602 922 3212 2800 2897 2708 2444 3088 M15678 GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 5/16 Gene Ontology BP GO:0043455 0.275742742869669 0.392721949430635 3835 3052.18181818182 2897 0.0317460317460317 1209 1.46584243959724 1.46584243959724 1 2.25854857607359 3834 1714 4439 2093 2734 2897 4623 4462 1935 1209 3634 3089 M13154 GO_CELLULAR_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 20/64 Gene Ontology BP GO:0071320 0.0591498259123006 0.137937037524265 2025 2845.81818181818 2898 0.0055275187352386 1050 0.900416075626817 0.900416075626817 1 2.94042454123479 2022 3659 2191 3828 1050 2898 1845 3935 4115 3663 2098 3090 M13895 GO_SPERMATID_NUCLEUS_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_NUCLEUS_DIFFERENTIATION.html The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. 11/134 Gene Ontology BP GO:0007289 0.0350495704543221 0.0957829050143717 3355 2822.54545454545 2898 0.00323824982325197 794 0.351931889027212 -0.35821782900777 -1 1.36087197840362 3353 2898 2610 3587 794 2223 3955 1737 3671 3866 2354 3091 M15275 GO_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_MOVEMENT.html A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules. 122/278 Gene Ontology BP GO:0007018 0.00494007150468944 0.0248771713625521 1330 2394.09090909091 2898 0.000450109033589611 58 0.831293747769975 -0.738264275367823 -1 5.06197489697989 1327 4387 3088 4407 4473 58 952 803 3761 2898 181 3092 M16926 GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 18/56 Gene Ontology BP GO:0002312 0.177506668864211 0.279188165154651 2760 2942.45454545455 2900 0.0176081241406955 777 0.847293883868049 0.847293883868049 1 1.78209889330344 2758 4329 2900 3561 4019 2884 777 1147 3081 4632 2279 3093 M10934 GO_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLATION.html The modification of histones by addition of methyl groups. 42/94 Gene Ontology BP GO:0016571 0.162274180255606 0.259627504799028 2085 2798.09090909091 2901 0.0159679045170751 695 0.215294998525296 -0.221202197968312 -1 0.478606729493274 2083 4450 3446 4588 2901 695 2883 1862 4013 3123 735 3094 M11996 GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 70/157 Gene Ontology BP GO:0002224 0.597318307603006 0.701403364238937 2615 3142.81818181818 2901 0.0793650793650794 2164 1.29688960462796 1.29688960462796 1 0.758266086682921 3142 3133 2164 2889 3783 4200 2611 2651 2901 2611 4486 3095 M12286 GO_PEPTIDYL_LYSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_MODIFICATION.html The modification of peptidyl-lysine. 179/381 Gene Ontology BP GO:0018205 0.0782810853806264 0.158445571591463 2200 2720.09090909091 2901 0.00738306182475934 315 1.20492047657789 -0.936134895625951 -1 3.65949101286904 2200 4588 3399 4476 3613 315 1870 2182 3684 2901 693 3096 M13137 GO_AMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 290/656 Gene Ontology BP GO:0043604 0.155261194550578 0.258740097879113 1215 2487.72727272727 2902 0.0152218497975968 735 0.903494440599483 -0.86694480506707 -1 2.0135926585797 1214 4215 3515 4045 1558 735 2962 1984 2902 2929 1306 3097 M10297 GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. 10/17 Gene Ontology BP GO:1904872 0.693690803059336 0.782508843198371 2490 2844.09090909091 2903 0.101977380090296 1452 0.29130316091569 -0.272113014346804 -1 0.117773031244156 2490 2821 2989 3267 2903 1452 2676 3052 4150 2996 2489 3098 M13098 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion. 7/17 Gene Ontology BP GO:2000778 0.236198408317045 0.346937427970908 1680 2610.90909090909 2903 0.0265849515542911 796 0.402580691416974 0.563172576252763 1 0.702555793886013 1679 2903 4011 3471 3036 1738 796 1855 3641 3649 1941 3099 M15391 GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/39 Gene Ontology BP GO:0032891 0.797574451264887 0.871942118489021 2300 2936.27272727273 2903 0.135165091358706 1740 0.451700299871039 0.43915722807321 1 0.102038640131804 2298 2394 1740 2839 2947 3851 2248 2903 3399 4255 3425 3100 M15528 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. 15/55 Gene Ontology BP GO:0046638 0.597318307603006 0.701403364238937 3520 3045.90909090909 2903 0.0793650793650794 1539 0.394763490093874 -0.317761827787907 -1 0.230810522014343 3516 2503 2113 3225 2701 1539 3629 4515 2903 4297 2564 3101 M15865 GO_GERM_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. 110/412 Gene Ontology BP GO:0007281 0.100286536796971 0.182815229818742 3225 2677.81818181818 2903 0.00956117492864553 836 1.76816527145432 2.02063556096797 1 4.95312362997595 3222 4437 2903 3445 1311 836 3366 3389 2659 1849 2039 3102 M10863 GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL.html The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 13/53 Gene Ontology BP GO:0086010 0.161385165508919 0.258740097879113 2650 2899.63636363636 2904 0.0158730158730159 869 1.40606340631805 -1.42279293755586 -1 3.13365398316115 2650 3101 1882 2904 4275 4009 4424 2765 1410 869 3607 3103 M14404 GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. 10/17 Gene Ontology BP GO:1904874 0.693690803059336 0.782508843198371 2495 2937.90909090909 2904 0.101977380090296 1453 0.29130316091569 -0.272113014346804 -1 0.117773031244156 2491 2822 2990 3268 2904 1453 2677 3067 4151 4004 2490 3104 M16400 GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html The directed movement of proteins from the endoplasmic reticulum. 15/29 Gene Ontology BP GO:0032527 0.0157344305632595 0.0559808131074437 2905 2667.63636363636 2904 0.00144073665955302 508 0.522536967759313 0.522536967759313 1 2.48321876819703 2904 3287 3318 3190 508 1216 2352 2128 4167 4490 1784 3105 M11051 GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type peptidase activity. 2/15 Gene Ontology BP GO:1902571 0.0587488772741021 0.137277824450758 3215 2315.5 2904.5 0.00670467900789771 16 1.99575500943266 1.99575500943266 1 6.53315574573886 3212 167 3676 NA 4393 4244 3067 791 16 847 2742 3106 M14270 GO_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_ELONGATION.html The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. 70/123 Gene Ontology BP GO:0006414 0.448605935259577 0.568024695785855 860 3023.81818181818 2905 0.0526803336175007 860 0.751302067173766 0.751302067173766 1 0.700500004104069 860 4088 3494 4110 2905 1710 2863 2692 4039 3965 2536 3107 M14637 GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 11/25 Gene Ontology BP GO:0046386 0.302125994871001 0.417118939692554 1565 2289.45454545455 2905 0.0321726047199175 847 0.55936453995665 -0.55936453995665 -1 0.806285058091335 1562 2933 3077 2905 2999 847 942 1401 3301 4063 1154 3108 M11683 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. 2/12 Gene Ontology BP GO:1902572 0.058335474314052 0.136862863688804 3215 2327.2 2905.5 0.00665621501473496 17 1.99575500943266 1.99575500943266 1 6.54311582126449 3213 168 3789 NA 4394 4245 3068 787 17 848 2743 3109 M10436 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 762/2161 Gene Ontology BP GO:0010629 0.0210949368898526 0.0681645940254237 2910 2794.63636363636 2906 0.00212979021977212 629 1.20318960088745 1.3319865807253 1 5.32726293060671 2906 2952 3583 3622 629 2180 2355 3284 2681 2447 4102 3110 M11047 GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. 87/342 Gene Ontology BP GO:0050851 0.0839184282471183 0.158445571591463 3330 2768.09090909091 2906 0.00793650793650794 1009 1.56326037081979 1.56326037081979 1 4.7478131453955 3328 2837 2906 2062 2492 3284 2931 3671 1009 1920 4009 3111 M13174 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. 2/12 Gene Ontology BP GO:1900004 0.0583965628092905 0.1368918827221 3215 2352.2 2906.5 0.00666337534095627 18 1.99575500943266 1.99575500943266 1 6.54241831188707 3214 169 4028 NA 4395 4246 3069 789 18 850 2744 3112 M10053 GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. 11/25 Gene Ontology BP GO:1900225 0.426492608087928 0.545811791442186 2265 2833 2907 0.0492879427644839 1601 0.292258587375851 0.389803206230446 1 0.291715422736686 2264 3607 2889 2931 3384 2496 2907 1601 3346 2944 2794 3113 M12435 GO_MITOTIC_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis. 20/58 Gene Ontology BP GO:0090307 0.878859116702268 0.937274247587117 2910 3073.63636363636 2907 0.174603174603175 2436 0.768455391592508 -0.768455391592508 -1 0.082062890032716 2907 3050 2436 2693 4181 2570 3702 2502 3457 3487 2825 3114 M15644 GO_GTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GTP, guanosine triphosphate. 14/28 Gene Ontology BP GO:0046039 0.63389956273523 0.731410454716618 2350 2917.45454545455 2907 0.0873015873015873 1618 0.714092449815773 -0.686007751272719 -1 0.368201559981199 2350 2461 3219 2907 4029 1618 2585 3519 2972 4323 2109 3115 M15771 GO_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_CHECKPOINT.html A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. 126/269 Gene Ontology BP GO:0000075 0.732323032585191 0.814023423579852 1910 2972.18181818182 2907 0.112916223534834 1549 1.19543171804843 -1.00026403401684 -1 0.405499405864919 1910 4247 3024 3870 3589 1549 2761 2907 3899 2739 2199 3116 M15052 GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. 2/15 Gene Ontology BP GO:1900003 0.0586792517118255 0.137200667935398 3215 2384.3 2907.5 0.00669651534973925 19 1.99575500943266 1.99575500943266 1 6.53500541067237 3215 170 4339 NA 4396 4247 3070 790 19 852 2745 3117 M13120 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS.html Any microtubule cytoskeleton organization that is involved in mitosis. 20/58 Gene Ontology BP GO:1902850 0.878859116702268 0.937274247587117 2910 3090.54545454545 2908 0.174603174603175 2437 0.768455391592508 -0.768455391592508 -1 0.082062890032716 2908 3051 2437 2694 4182 2571 3703 2513 3458 3653 2826 3118 M10459 GO_POSITIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEMOPOIESIS.html Any process that activates or increases the frequency, rate or extent of hemopoiesis. 95/254 Gene Ontology BP GO:1903708 0.00267141979546905 0.0161083144290426 3395 2567.54545454545 2911 0.000243151743361899 447 1.43992446817495 1.43992446817495 1 9.79975227466453 3394 2047 447 1365 3038 3226 3398 2911 1843 2099 4475 3119 M10304 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. 13/25 Gene Ontology BP GO:1900015 0.503155874401615 0.61966915778427 2215 2798.09090909091 2912 0.0616093954349745 1738 1.35593454827845 1.35593454827845 1 1.0697328679908 2214 3251 1741 3480 3547 3778 2760 1738 3434 1924 2912 3120 M12441 GO_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGY.html The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. 267/578 Gene Ontology BP GO:0006914 0.0348368669751136 0.0955078729381172 2890 2780.18181818182 2912 0.0032182776760412 196 0.954784288918286 -0.699753364564374 -1 3.69654491522238 2887 4274 3260 4540 2323 196 3172 2801 3234 2912 983 3121 M10912 GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. 18/42 Gene Ontology BP GO:0033006 0.118403050718687 0.209754039339656 2505 2970 2913 0.0113910164450675 1396 0.905815316330878 -0.664904966411386 -1 2.33218013604083 2504 4137 2913 3734 1396 3522 2558 3527 3291 2187 2901 3122 M12708 GO_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of mast cell degranulation. 18/42 Gene Ontology BP GO:0043304 0.118403050718687 0.209754039339656 2505 2974.27272727273 2914 0.0113910164450675 1397 0.905815316330878 -0.664904966411386 -1 2.33218013604083 2505 4138 2914 3735 1397 3523 2559 3554 3292 2198 2902 3123 M12893 GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT.html The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 11/44 Gene Ontology BP GO:0015697 0.773074592248617 0.851372232402829 3320 3145.54545454545 2914 0.126135855054181 2168 0.432180134165817 0.373763901300084 1 0.11463788078603 3317 2507 2168 2791 2871 4257 4308 2468 3405 3595 2914 3124 M14082 GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 14/44 Gene Ontology BP GO:0044058 0.161368531047844 0.258740097879113 2085 2922.90909090909 2914 0.015871241271967 1578 0.40324796524224 0.431052347925375 1 0.898707402971628 2082 3392 1797 2914 1578 2677 3154 4252 4092 3917 2297 3125 M16655 GO_RESPONSE_TO_IRON_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IRON_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. 21/50 Gene Ontology BP GO:0010039 0.0839184282471183 0.158445571591463 2915 2910.18181818182 2914 0.00793650793650794 1126 1.63763913842182 -1.03069309216194 -1 4.97371056924384 2914 3596 1808 3434 4406 4628 4072 1912 1126 1236 2880 3126 M11764 GO_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. 61/145 Gene Ontology BP GO:0019722 0.182069545464771 0.285398007965203 2370 2921 2915 0.0181048262965248 1072 1.20598116391392 1.30194301307648 1 2.49278469995181 2369 2915 1072 3082 3508 4139 2849 3747 2790 1917 3743 3127 M13792 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. 80/189 Gene Ontology BP GO:1903747 0.466738071388703 0.580826820010117 4265 3098.63636363636 2915 0.0555555555555556 1751 1.10216134560427 -0.715074193497871 -1 0.987139504451407 4262 2092 2915 2690 4382 1751 3925 3543 2566 2344 3615 3128 M16234 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 220/537 Gene Ontology BP GO:0010639 0.202419412147556 0.310073682151469 2650 2641.54545454545 2915 0.020351188511617 605 0.87922809299517 -0.851502363709765 -1 1.69718707475026 2647 3676 2783 3001 3692 605 3183 2032 3383 2915 1140 3129 M11265 GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. 45/105 Gene Ontology BP GO:1901606 0.0206755338178674 0.0674132749412629 3980 2438.09090909091 2916 0.00189749431622838 594 1.13684482097034 1.21148834014316 1 5.05428490161789 3977 1095 943 1422 594 2916 4381 3971 2970 1362 3188 3130 M11758 GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. 67/154 Gene Ontology BP GO:1903650 0.0839184282471183 0.158445571591463 3310 2483 2916 0.00793650793650794 1099 1.28830494493046 1.41699144328977 1 3.91273985251899 3309 3375 1495 2916 3401 2363 2993 1624 1099 1360 3378 3131 M12761 GO_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_MODIFICATION.html The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure. 279/725 Gene Ontology BP GO:0016568 0.129766750761667 0.225658061343229 1805 2715.63636363636 2916 0.0125563214813616 438 1.19697659260028 -1.03463152579236 -1 2.93761198899808 1805 4582 3353 4601 3685 438 2379 2118 3231 2916 764 3132 M14362 GO_GOLGI_RIBBON_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_RIBBON_FORMATION.html The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. 7/13 Gene Ontology BP GO:0090161 0.134429367191499 0.232287142489815 2375 2817.27272727273 2917 0.0143329213704139 589 0.221895931586323 -0.207318925543494 -1 0.53398441948574 2372 3368 4228 3730 2917 1027 589 2759 4512 3986 1502 3133 M13455 GO_SPINAL_CORD_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_PATTERNING.html The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. 7/34 Gene Ontology BP GO:0021511 0.275742742869669 0.392721949430635 2920 2760.45454545455 2918 0.0317460317460317 1409 1.49234186417521 1.49234186417521 1 2.29937850160669 2918 1456 4077 1543 3270 3705 4523 2578 1943 1409 2943 3134 M14408 GO_CELLULAR_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 23/62 Gene Ontology BP GO:0071359 0.433167848584632 0.552527011257815 2065 2910.45454545455 2919 0.0502992728113193 1017 0.610681132932434 0.610681132932434 1 0.597235970863752 2919 3951 3258 3353 2797 1017 2062 2318 4272 4006 2062 3135 M16099 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 8/30 Gene Ontology BP GO:0055015 0.00756236913540505 0.033449032437885 1850 2526.09090909091 2919 0.000758822831628698 139 1.70820157422404 1.70820157422404 1 9.56797064099533 1848 3258 4507 2919 4008 761 139 3592 3577 1529 1649 3136 M11321 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION.html The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. 18/23 Gene Ontology BP GO:0006295 0.429774811944474 0.54880210447145 2265 2751.27272727273 2920 0.0497838669256267 1010 0.16034306064544 -0.195789275442583 -1 0.158600858059374 2265 4408 3444 3805 2920 1010 1765 2389 3622 3223 1413 3137 M11762 GO_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_PROCESS.html Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. 289/703 Gene Ontology BP GO:0007017 0.0176636614112968 0.0608698748517488 1795 2532.72727272727 2920 0.00161882697598972 129 0.896717628965571 -0.718611836238979 -1 4.13764064781675 1791 4355 3096 4593 3075 129 1962 1689 3679 2920 571 3138 M11566 GO_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_MOVEMENT.html Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. 60/158 Gene Ontology BP GO:0030048 0.000691188212016876 0.00636627283921067 4210 2746.54545454545 2921 6.28550420586891e-05 347 2.05496179896089 -2.2038900244525 -1 17.1303412038502 4209 3137 347 2877 3054 2565 3995 2921 2201 1168 3738 3139 M13239 GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. 176/377 Gene Ontology BP GO:1903320 0.0181386588392397 0.0618339155584359 2040 2675.27272727273 2921 0.00166272350876929 132 0.953953927843298 0.953953927843298 1 4.37702949003843 2038 3798 3426 3921 3690 132 2858 2499 3551 2921 594 3140 M16455 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION.html The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 18/23 Gene Ontology BP GO:0006293 0.429774811944474 0.54880210447145 2270 2868.72727272727 2921 0.0497838669256267 1011 0.16034306064544 -0.195789275442583 -1 0.158600858059374 2266 4409 3445 3806 2921 1011 1766 2390 3623 4505 1414 3141 M11463 GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL.html The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. 983/2289 Gene Ontology BP GO:0051649 0.0111779837944111 0.0441101679359682 2860 2683.09090909091 2922 0.00112346113912132 105 1.15086688715221 1.33534923749538 1 5.92133244502856 2857 4381 3750 4604 1271 105 3232 2841 2978 2922 573 3142 M12251 GO_POLYAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. 8/17 Gene Ontology BP GO:0006595 0.55704121443357 0.666249592815201 1835 2756.36363636364 2922 0.0782007891661445 1590 0.801128877993451 0.801128877993451 1 0.536311614647127 1832 2579 3878 3414 2922 2105 1703 3239 3610 3448 1590 3143 M11124 GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that activates or increases the frequency, rate or extent of viral genome replication. 20/50 Gene Ontology BP GO:0045070 0.562905276809168 0.671178531131219 1940 2890.81818181818 2923 0.0724762236539537 1324 0.296989893426249 0.342205678754619 1 0.195209681608965 1939 3502 2307 4124 3032 2923 1324 2724 4418 3173 2333 3144 M16504 GO_AUTOPHAGOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. 29/52 Gene Ontology BP GO:1905037 0.28791184478982 0.406314497069646 2165 2783.72727272727 2923 0.0303969379453912 769 0.757413120848284 -0.757413120848284 -1 1.12452654839203 2162 2923 3190 3324 3925 769 2259 2600 3619 4517 1333 3145 M10598 GO_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_PROTEIN_TRANSPORT.html The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. 469/1034 Gene Ontology BP GO:0006886 0.0343846332433127 0.0945782144473027 2160 2613.18181818182 2924 0.00317582773116123 195 0.987181937103264 1.15244595439762 1 3.8378939694975 2160 4117 3507 4233 2213 195 3073 2530 3064 2924 729 3146 M10784 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. 16/48 Gene Ontology BP GO:0045197 0.232850105696956 0.342669743502683 4425 2975.72727272727 2924 0.0238095238095238 998 1.49222986980147 1.49222986980147 1 2.63458329566588 4422 1969 2323 2089 3378 2924 4445 4333 1708 998 4144 3147 M16766 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. 87/198 Gene Ontology BP GO:0032387 0.35943518917414 0.479556776820555 3740 2928 2924 0.0396825396825397 1300 1.28830494493046 1.41699144328977 1 1.56075349767875 3736 3703 1583 2924 4380 1300 3456 2371 2261 1921 4573 3148 M12587 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization. 11/39 Gene Ontology BP GO:0031113 0.230114895306203 0.342669743502683 2535 2796.18181818182 2925 0.0234936238453758 1259 0.248763364421348 -0.291408788703402 -1 0.439200298507164 2535 3786 3162 3647 2663 1621 2925 1259 4085 3530 1545 3149 M14814 GO_FEMALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GAMETE_GENERATION.html Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. 47/155 Gene Ontology BP GO:0007292 0.0839184282471183 0.158445571591463 3815 2398.18181818182 2925 0.00793650793650794 573 1.56582090970667 -1.11100625844536 -1 4.75558981549717 3815 3379 1114 695 1525 3938 3735 2925 637 573 4044 3150 M15308 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of magnesium ion across a membrane. 5/18 Gene Ontology BP GO:1903830 0.463321522976403 0.580826820010117 1670 2979.81818181818 2926 0.0603385332159266 1216 0.403507452942448 0.593099693508844 1 0.361397311387342 1668 3672 4383 3718 3637 2385 1216 2200 2740 4233 2926 3151 M13350 GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 25/86 Gene Ontology BP GO:0050922 0.00919947045191267 0.0381531618878865 2875 2986.63636363636 2927 0.000839833224494402 565 1.10683285770696 -0.895126889563846 -1 5.95949233455505 2874 2492 565 2153 4627 4430 2927 4238 2948 1383 4216 3152 M15552 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 52/127 Gene Ontology BP GO:0051279 0.174430540124809 0.275188922120111 3755 2961.81818181818 2927 0.0172746769793221 1628 1.14413454014118 1.34463734700163 1 2.43365196675601 3753 3342 1961 2927 1628 3224 3856 2777 2462 2378 4272 3153 M12955 GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. 86/264 Gene Ontology BP GO:1903707 0.0928271402015325 0.171711717910644 2930 2955.36363636364 2928 0.0088174654717804 1279 1.12008274395866 1.12008274395866 1 3.25336160405346 2928 3374 1295 3704 1279 4022 2592 4027 2317 2723 4248 3154 M10265 GO_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXPORT_FROM_NUCLEUS.html The directed movement of a protein from the nucleus into the cytoplasm. 23/55 Gene Ontology BP GO:0006611 0.414130368408418 0.535202348257472 1065 2480.27272727273 2929 0.0474429430257778 992 0.289036680073418 -0.310125712618619 -1 0.297852475917113 1063 3384 3108 3444 2929 992 1925 2042 3735 2989 1672 3155 M11021 GO_ADULT_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_WALKING_BEHAVIOR.html The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 21/79 Gene Ontology BP GO:0007628 0.0839184282471183 0.158445571591463 4060 2949.36363636364 2929 0.00793650793650794 1204 1.31394404283802 1.31394404283802 1 3.99060893201362 4056 2812 2039 2929 2198 3289 3991 3083 1204 2317 4525 3156 M16566 GO_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_WALKING_BEHAVIOR.html The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 21/79 Gene Ontology BP GO:0090659 0.0839184282471183 0.158445571591463 4060 2949.63636363636 2930 0.00793650793650794 1205 1.31394404283802 1.31394404283802 1 3.99060893201362 4057 2813 2040 2930 2199 3290 3992 3056 1205 2338 4526 3157 M15084 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 11/35 Gene Ontology BP GO:1902236 0.275023977624764 0.392721949430635 2935 2890.36363636364 2931 0.0288145901233219 742 0.522536967759313 0.522536967759313 1 0.80511731167776 2931 2131 2930 2324 4402 742 3516 3713 3808 4180 1117 3158 M10125 GO_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION.html A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. 530/1244 Gene Ontology BP GO:0051276 0.356420831317613 0.479556776820555 755 2865.45454545455 2932 0.0431140059747289 752 1.13974373402447 -1.02995477133261 -1 1.38077481291192 752 4641 3539 4611 3672 1028 2623 2263 3809 2932 1650 3159 M11046 GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION.html Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. 7/17 Gene Ontology BP GO:0032928 0.00266264537936119 0.0161083144290426 3445 2614.18181818182 2933 0.000266584112598769 179 0.484729741140519 -0.553991927927056 -1 3.29894483228769 3445 905 3675 1668 179 2933 3795 2871 2923 3150 3212 3160 M15825 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION.html The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. 15/30 Gene Ontology BP GO:0040001 0.816521443770307 0.888471774882948 3045 3202.45454545455 2933 0.142857142857143 2658 0.889829409089437 -0.889829409089437 -1 0.173463560875165 3045 2852 2761 2881 3493 2786 4123 2658 3334 4361 2933 3161 M10830 GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mitochondrial DNA. 11/18 Gene Ontology BP GO:0032042 0.429417954650007 0.548770837951972 3205 2718.36363636364 2934 0.0497298220667683 1098 0.231153581283019 -0.276406196967144 -1 0.228663699668743 2613 2934 3202 3537 3205 2221 1098 1827 4138 3097 2030 3162 M13371 GO_NCRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). 313/678 Gene Ontology BP GO:0034660 0.703468348163927 0.789701049449979 1750 3086.18181818182 2934 0.10462191666214 1562 0.979699182909658 -0.622861546586804 -1 0.381313156438248 1747 4581 3516 4528 2745 1562 3843 2576 3685 2934 2231 3163 M10034 GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. 3/22 Gene Ontology BP GO:0042053 0.579857310453667 0.686805482764382 3290 3103.54545454545 2937 0.0830626125599813 1994 0.423033407437734 0.556112068397604 1 0.262006592745068 3290 1994 3520 3174 2593 4389 2888 2564 4032 2937 2758 3164 M11770 GO_POSITIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BINDING.html Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 36/70 Gene Ontology BP GO:0043388 0.0839184282471183 0.158445571591463 4455 2998.81818181818 2938 0.00793650793650794 1091 1.9083122944764 1.9083122944764 1 5.79577808432812 4454 2842 2938 3196 1535 2289 4340 4558 1091 2627 3117 3165 M10037 GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that activates or increases the frequency, rate or extent of viral transcription. 22/51 Gene Ontology BP GO:0050434 0.046207607207975 0.115860574033061 4315 2902.72727272727 2939 0.00429160543201992 934 0.352084401180512 -0.397873659118869 -1 1.25100691097855 4313 1432 3254 2296 934 4429 2405 3784 2227 2939 3917 3166 M10051 GO_GLUCURONATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. 7/28 Gene Ontology BP GO:0019585 0.0765897756730953 0.158445571591463 2045 2280.81818181818 2942 0.00793650793650794 151 0.611481234588787 0.759365130362717 1 1.85714337660363 2044 151 3525 458 4291 3351 3793 1380 161 2942 2993 3167 M11752 GO_PURINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. 9/17 Gene Ontology BP GO:0043101 0.0298888631753444 0.0860779733032323 1075 2180.27272727273 2942 0.0030298646676393 186 0.297348297513831 -0.297348297513831 -1 1.20217120267906 1072 2942 3800 2947 4604 186 691 575 3403 3336 427 3168 M10052 GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 6/19 Gene Ontology BP GO:0071402 0.0498199328918346 0.122194373173158 2175 2856.27272727273 2943 0.00509734104224635 375 0.633042077535849 0.633042077535849 1 2.19374542144301 2171 3305 3526 2841 4261 1975 375 4552 3651 2943 1819 3169 M16969 GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. 7/23 Gene Ontology BP GO:0031998 0.314566056326159 0.43223740737566 4645 3296.18181818182 2944 0.0370659126903842 1474 0.329667773381614 -0.139317644168206 -1 0.455844010135653 2799 2868 4642 3061 2091 4439 4362 1474 2944 4642 2936 3170 M10062 GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 25/50 Gene Ontology BP GO:0050856 0.372283727523899 0.493297188040371 2195 2944.90909090909 2946 0.0414498193435977 1268 0.352048893748603 0.377521476646411 1 0.410104823058607 2192 4503 1268 4496 4411 2712 1750 2142 2990 2946 2984 3171 M12607 GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. 14/34 Gene Ontology BP GO:0002292 0.161385165508919 0.258740097879113 4610 2883.36363636364 2946 0.0158730158730159 914 0.999874348461293 0.984464976610968 1 2.22839184958901 4606 1906 1661 2946 3673 4625 4087 1920 1486 914 3893 3172 M12155 GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. 271/568 Gene Ontology BP GO:0010608 0.214544465388549 0.323208939908835 2950 2827.18181818182 2947 0.0217145363568629 689 1.27776076451602 1.37069363514295 1 2.37908807368949 2947 3649 3467 4393 1758 689 3186 3339 2905 2762 2004 3173 M11352 GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. 9/12 Gene Ontology BP GO:0051103 0.598881260040338 0.702350515374411 2170 2901.81818181818 2950 0.0873015873015873 1768 0.277299975157984 -0.357466687411806 -1 0.161515014497917 2169 3548 3734 3821 4416 1947 1768 2510 2950 3234 1823 3174 M10148 GO_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_FIBER_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. 13/22 Gene Ontology BP GO:0043149 0.571080219433177 0.679355741436905 2150 2946.81818181818 2951 0.0740668279790174 1687 0.33350750931569 0.264302349072689 1 0.212554672714598 2147 3099 2951 3836 2501 2651 1687 4294 3501 2964 2784 3175 M11327 GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. 84/198 Gene Ontology BP GO:0098780 0.372692467602242 0.493416346471973 4275 2920.36363636364 2951 0.04150657832347 920 1.0643284287678 1.18536382612266 1 1.23942168782359 4273 3129 2072 3927 3600 920 3210 2951 2895 2705 2442 3176 M13851 GO_METHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 9/21 Gene Ontology BP GO:0006555 0.663427224845798 0.758360461288678 1695 2949.90909090909 2951 0.103174603174603 1692 0.386796317395496 -0.536147930175164 -1 0.176368286680666 1692 3509 4144 3116 2951 1877 2670 2930 3067 3852 2641 3177 M16432 GO_TEMPERATURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TEMPERATURE_HOMEOSTASIS.html A homeostatic process in which an organism modulates its internal body temperature. 10/35 Gene Ontology BP GO:0001659 0.0345615830721548 0.095008543637664 3015 2876.45454545455 2951 0.00319243537534811 576 0.858982002181133 0.858982002181133 1 3.33305926358987 3015 2272 1598 2951 3680 4526 3145 576 2617 4497 2764 3178 M10418 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 33/100 Gene Ontology BP GO:0042509 0.50597781691511 0.622162743296806 3670 3039.45454545455 2952 0.0620951789797552 1595 0.943194700221817 -0.671837249370926 -1 0.737867095487357 3666 2453 1595 1993 2392 3607 4314 3256 2952 2585 4621 3179 M11075 GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. 13/22 Gene Ontology BP GO:0030038 0.571080219433177 0.679355741436905 2150 2966.45454545455 2952 0.0740668279790174 1688 0.33350750931569 0.264302349072689 1 0.212554672714598 2148 3100 2952 3837 2502 2652 1688 4307 3502 3158 2785 3180 M12774 GO_PIGMENT_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. 26/55 Gene Ontology BP GO:0046148 0.0117521826268299 0.045592617285168 2940 2750.81818181818 2952 0.00107413047074682 434 0.648828184364399 0.648828184364399 1 3.30293383387391 2937 3806 3026 3932 434 1641 2952 2556 3302 3572 2101 3181 M13794 GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. 16/51 Gene Ontology BP GO:0045589 0.682312854940234 0.772866207730546 1840 2877.45454545455 2952 0.0989949188310696 1425 0.299855450095935 -0.31233689436519 -1 0.127359839007064 1838 4069 2180 3958 3006 1425 1997 2952 4269 3836 2122 3182 M16017 GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/55 Gene Ontology BP GO:0032892 0.0163591633045046 0.057520768137511 2560 3015.54545454545 2952 0.00149837194706613 403 0.414495207940706 0.471000719601333 1 1.95123613679282 2556 2744 2356 2314 2952 4315 4487 403 3142 4400 3502 3183 M11372 GO_ORGANOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. 430/1043 Gene Ontology BP GO:0019637 0.0193416874986757 0.0645855161278877 3120 2419 2953 0.00177398692982414 384 1.1881651883968 1.41943726107601 1 5.36638337945053 3118 2953 2988 3098 575 384 3199 3943 2453 2656 1242 3184 M12735 GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is divided into specific regions along the rostrocaudal axis. 10/21 Gene Ontology BP GO:0021903 0.408986164145946 0.531464528443781 2375 2919.90909090909 2953 0.0466856073684134 1056 0.322189780289199 -0.203748746641567 -1 0.335739179648042 2375 3187 2666 3343 3866 2953 1056 2922 4157 3562 2032 3185 M16214 GO_RUFFLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. 17/42 Gene Ontology BP GO:0031529 0.0839184282471183 0.158445571591463 4095 2750.54545454545 2953 0.00793650793650794 535 0.973580524539897 -0.876953256285143 -1 2.95688325418447 4093 2927 1589 1089 2953 3101 3923 4532 535 2163 3351 3186 M13837 GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 61/138 Gene Ontology BP GO:0033209 0.384202537832417 0.505770451702839 3920 3106 2955 0.0431188695800882 1103 1.86280643978199 1.86280643978199 1 2.09331681142046 3919 3908 2948 4093 2168 1103 3354 4024 2894 2800 2955 3187 M11586 GO_ACETYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. 13/26 Gene Ontology BP GO:0006084 0.453595633904122 0.573073341011385 1505 2859.90909090909 2958 0.0534628782681558 1504 0.309086381744695 0.368161904480141 1 0.283677614979649 1504 4176 1921 4188 3972 2958 1531 1651 4358 3294 1906 3188 M10121 GO_HEMOGLOBIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. 7/15 Gene Ontology BP GO:0020027 0.632427457617131 0.731410454716618 2815 3156.54545454545 2959 0.0952380952380952 2091 0.852246096011289 0.852246096011289 1 0.439436577357237 2814 3444 3538 2091 4414 2839 2651 4072 3037 2959 2863 3189 M12630 GO_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 57/139 Gene Ontology BP GO:0055076 0.415320710913563 0.535202348257472 2090 2878.81818181818 2959 0.0476190476190476 1086 1.21831602395311 -0.930896232997513 -1 1.25547540975137 2089 3234 2959 3674 4294 2435 1086 3631 2441 2453 3371 3190 M15337 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. 11/42 Gene Ontology BP GO:0032743 0.554908062591548 0.665918359941215 4190 3051.81818181818 2959 0.0709461565882091 2080 0.385718810743217 -0.409693800851546 -1 0.258533681215002 4189 3152 2190 2959 2468 2080 3597 2820 3260 4244 2611 3191 M16023 GO_RNA_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_LOCALIZATION.html A process in which RNA is transported to, or maintained in, a specific location. 111/248 Gene Ontology BP GO:0006403 0.707515081582247 0.793668162306444 2230 3075.54545454545 2959 0.105739696988155 1495 1.21648013088035 -0.903367480678587 -1 0.463422811597474 2228 4438 3454 4590 2959 1495 3112 2602 3829 2816 2308 3192 M14216 GO_DETECTION_OF_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_VISIBLE_LIGHT.html The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 15/83 Gene Ontology BP GO:0009584 0.466738071388703 0.580826820010117 1835 2858.45454545455 2960 0.0555555555555556 964 1.25817641655187 1.25817641655187 1 1.12687280254247 1834 3814 1859 3526 3550 3993 3522 2843 2578 964 2960 3193 M10974 GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. 56/165 Gene Ontology BP GO:0048525 0.63389956273523 0.731410454716618 4040 3091.27272727273 2961 0.0873015873015873 1872 1.11976417269809 1.11976417269809 1 0.577374701800364 4036 2806 1872 3768 3540 3115 2624 2157 2961 2778 4347 3194 M12121 GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 15/43 Gene Ontology BP GO:0010743 0.275322430642142 0.392721949430635 3120 2968.81818181818 2961 0.0288509433593149 1179 0.484248798493555 -0.535260322702955 -1 0.746123460874685 3117 2215 1179 2341 4168 2755 2961 4281 3533 3417 2690 3195 M14803 GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 20/51 Gene Ontology BP GO:0046685 0.274633606472661 0.392721949430635 2965 2799.18181818182 2961 0.0287670612778165 1152 1.20335701059157 1.20335701059157 1 1.85411486890779 2961 2637 2098 3875 1920 4253 2963 2341 3265 1152 3326 3196 M15820 GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION.html Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. 7/29 Gene Ontology BP GO:0007263 0.121869571462378 0.214414710231081 1230 2622.81818181818 2961 0.0129119309001378 956 0.480417406968832 0.649287509694904 1 1.2195139938953 1228 3406 4462 3946 2961 1513 956 1010 3819 4360 1190 3197 M10317 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 20/52 Gene Ontology BP GO:0050732 0.0839184282471183 0.158445571591463 4355 2920.09090909091 2962 0.00793650793650794 544 1.50975035221225 -0.664904966411386 -1 4.58529666733018 4352 3809 2152 1793 2243 2962 4395 3580 544 2278 4013 3198 M12604 GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER.html The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. 12/41 Gene Ontology BP GO:0060795 0.545478713992644 0.656827423412031 1560 2692.54545454545 2963 0.0691738703398415 1295 0.411909321402029 0.450786400363218 1 0.28542213501264 1559 3105 2335 3176 3288 2539 1295 2963 3192 3535 2631 3199 M11257 GO_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOOD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. 7/27 Gene Ontology BP GO:0032094 0.103961773999797 0.188552545578538 2965 2797.09090909091 2964 0.0109171905675772 1378 0.346007256607982 0.349604324366579 1 0.951637063383178 2964 1990 3717 2793 1378 3239 2249 2007 3746 3202 3483 3200 M12659 GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. 13/31 Gene Ontology BP GO:0052312 0.0274721497042895 0.0811070991099343 3850 2798.90909090909 2967 0.00252921123863054 701 0.333726024072427 -0.342418641218922 -1 1.38197001951638 3846 1238 3158 2269 701 2536 4417 2967 2600 3548 3508 3201 M14956 GO_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid oxidation. 13/43 Gene Ontology BP GO:0046320 0.195250436441055 0.302016917255021 2440 3085.90909090909 2968 0.0195539424467564 1703 0.382318722184781 -0.155499341413529 -1 0.754588224047781 2439 3359 1986 4026 1703 4287 2656 2339 4044 4138 2968 3202 M10182 GO_CYTOKINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 6/19 Gene Ontology BP GO:0042107 0.144028490027816 0.245854514411452 3665 2967.36363636364 2969 0.0154315135442222 1094 0.43368815596009 -0.465823925413964 -1 1.00307063863051 3662 1817 3551 2937 3199 4252 2589 1094 2418 2969 4153 3203 M12148 GO_POLYSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 12/33 Gene Ontology BP GO:0000272 0.0839184282471183 0.158445571591463 4215 3015.54545454545 2969 0.00793650793650794 382 1.70956702222945 1.70956702222945 1 5.19216435893213 4213 2788 2770 2253 2969 3255 4205 3937 382 1867 4532 3204 M12832 GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. 21/61 Gene Ontology BP GO:0034123 0.63389956273523 0.731410454716618 3970 3316.36363636364 2969 0.0873015873015873 2301 1.29644110978073 1.29644110978073 1 0.668473163763617 3969 2528 2540 2426 4340 4522 3948 2301 2969 2325 4612 3205 M13229 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter. 15/31 Gene Ontology BP GO:0006356 0.161385165508919 0.258740097879113 3710 2799.54545454545 2973 0.0158730158730159 962 1.27429219455157 -1.33403223803043 -1 2.83997918813705 3707 3356 2973 3038 3169 2744 2904 2268 1285 962 4389 3206 M11131 GO_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. 73/119 Gene Ontology BP GO:0032543 0.236444744757527 0.347189421223655 565 2776.27272727273 2974 0.0242262431989565 565 0.657812056363 -0.564322045552235 -1 1.14718044199775 565 3878 3496 3711 2796 1630 2974 2671 3235 3175 2408 3207 M12579 GO_MAINTENANCE_OF_LOCATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION_IN_CELL.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. 59/136 Gene Ontology BP GO:0051651 0.126405455004414 0.220805315118697 3330 2664.45454545455 2974 0.0122101993110898 433 0.887150392504952 -0.749553583698932 -1 2.2090320383786 3330 3801 2826 3548 3020 433 3728 2036 2974 2791 822 3208 M12031 GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that activates or increases the frequency, rate or extent of translational initiation. 13/25 Gene Ontology BP GO:0045948 0.0126014781561112 0.0479972625749175 3270 2861.36363636364 2975 0.00115220390067875 354 0.324939863912756 -0.190257462860533 -1 1.62661113260608 3266 2930 2975 3379 2234 4340 2342 354 2272 3397 3986 3209 M13101 GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 7/19 Gene Ontology BP GO:0060192 0.0765897756730953 0.158445571591463 3210 2627.45454545455 2975 0.00793650793650794 229 1.99575500943266 1.99575500943266 1 6.06135231578909 3206 1708 4013 1211 4373 4172 2975 2302 229 1407 3306 3210 M16727 GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. 9/19 Gene Ontology BP GO:0006515 0.0141087358819564 0.0523217737219835 2560 2615.36363636364 2976 0.00141991199568401 210 0.312169940966567 -0.369194508893819 -1 1.51829123588622 2559 2976 4612 3815 3421 365 795 1573 3867 4576 210 3211 M13177 GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION.html A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. 9/20 Gene Ontology BP GO:0014829 0.524703658038309 0.636581939971745 2980 3014 2978 0.0716826931613322 1219 0.724851945550861 -0.867841409260423 -1 0.539678730155054 2978 2826 4029 3327 3462 1219 1876 4484 2823 3666 2464 3212 M14692 GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT.html The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. 9/24 Gene Ontology BP GO:0060749 0.386086746459241 0.506813899861537 3140 2982.81818181818 2978 0.0476190476190476 1613 1.03190356104762 1.03190356104762 1 1.15608911300371 3140 1804 4274 2060 2793 2978 4429 3912 2339 1613 3469 3213 M10217 GO_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_RECOMBINATION.html Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. 32/91 Gene Ontology BP GO:0000018 0.373216581657356 0.49396938102483 2660 3133.09090909091 2979 0.0415794077255577 1505 0.308176360447204 -0.324464911751489 -1 0.358305526953471 2658 3625 2947 3655 2143 1505 4273 4355 4083 2979 2241 3214 M15053 GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT.html The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. 9/24 Gene Ontology BP GO:0061377 0.386086746459241 0.506813899861537 3145 2992.36363636364 2979 0.0476190476190476 1618 1.03190356104762 1.03190356104762 1 1.15608911300371 3141 1805 4340 2061 2794 2979 4430 3938 2340 1618 3470 3215 M15803 GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. 8/33 Gene Ontology BP GO:0002825 0.000961667568505395 0.00791753767816902 735 2398.90909090909 2979 9.62083984178823e-05 45 0.453665829398921 0.453665829398921 1 3.61871237803748 731 2979 4460 2993 4555 293 45 2155 3158 4358 661 3216 M10176 GO_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 159/308 Gene Ontology BP GO:0007059 0.574803423395122 0.682472387017387 1040 3090.18181818182 2980 0.0748004078391635 1038 1.20238510924012 -0.674350887224881 -1 0.75724471426308 1038 4533 2682 4418 3899 1507 2980 3028 4487 2914 2506 3217 M16252 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. 59/208 Gene Ontology BP GO:1902106 0.667434366415499 0.758975695142582 2170 3033.27272727273 2981 0.0952380952380952 2031 1.12008274395866 1.12008274395866 1 0.509228985084506 2167 4162 2031 4159 2861 3332 2717 2981 3035 2482 3439 3218 M11118 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS.html A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. 8/27 Gene Ontology BP GO:0002087 0.275742742869669 0.392721949430635 4610 3157.72727272727 2983 0.0317460317460317 1499 1.38933387508025 1.38933387508025 1 2.14066529967705 4608 3550 3694 2967 2821 2983 2324 4105 2062 1499 4122 3219 M14502 GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. 14/30 Gene Ontology BP GO:0098927 0.0650820053863863 0.147211315059836 1755 2432.09090909091 2984 0.0060991839847719 485 0.290182574986382 -0.371227816001609 -1 0.916500240587194 1752 3634 2984 3527 3702 630 1435 1154 3419 4031 485 3220 M14717 GO_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEPHOSPHORYLATION.html The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. 137/325 Gene Ontology BP GO:0016311 0.0334906291147376 0.0932003951166524 3370 2939.45454545455 2984 0.00309196315932755 779 1.39053306113977 1.39053306113977 1 5.43965312871303 3369 3166 2966 3356 779 2464 2939 3140 2984 2625 4546 3221 M16013 GO_CELLULAR_COMPONENT_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY.html A cellular process that results in the breakdown of a cellular component. 334/744 Gene Ontology BP GO:0022411 0.162605080433242 0.26006730570153 3305 2803.36363636364 2985 0.016003246398511 775 1.21396924933712 1.33513214197747 1 2.69530000884906 3301 3701 2587 4366 1582 775 3271 3208 2985 2908 2153 3222 M10128 GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. 48/111 Gene Ontology BP GO:0043407 0.232850105696956 0.342669743502683 3610 2854.90909090909 2986 0.0238095238095238 1579 1.38728046031992 1.38728046031992 1 2.44929149396413 3607 3343 1579 2986 2785 3936 3431 1672 1902 2271 3892 3223 M10252 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS.html The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. 38/67 Gene Ontology BP GO:0097031 0.149217785798345 0.250950923337751 795 2553.90909090909 2986 0.0145834436245704 479 0.564322045552235 -0.564322045552235 -1 1.28612456690428 795 4393 3421 4279 3395 479 943 2089 4238 2986 1075 3224 M13379 GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 6/15 Gene Ontology BP GO:0009113 0.0574124490482541 0.13551906503866 2470 2830.90909090909 2986 0.00589520187304702 987 0.648828184364399 0.648828184364399 1 2.13774778236888 2468 3646 4063 3315 1078 2043 987 2986 4308 3724 2522 3225 M16600 GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 49/125 Gene Ontology BP GO:0043266 0.545493548282746 0.656827423412031 4370 3190.54545454545 2986 0.0691766321566278 1807 1.14050880909856 -1.28127221255727 -1 0.790286702700839 4368 2413 1807 2844 2448 3531 4227 4174 2986 2316 3982 3226 M11165 GO_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of exocytosis. 90/250 Gene Ontology BP GO:0017157 0.534164072934392 0.646370547467913 4070 3186.72727272727 2987 0.0670908303560449 1168 0.791360173003616 -0.70401694641583 -1 0.569289135147782 4069 4085 2886 4016 2824 1168 3663 3960 2987 2866 2530 3227 M13888 GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION.html The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential. 84/198 Gene Ontology BP GO:0098779 0.372692467602242 0.493416346471973 4275 2924.72727272727 2988 0.04150657832347 921 1.0643284287678 1.18536382612266 1 1.23942168782359 4274 3130 2073 3928 3601 921 3211 2988 2896 2707 2443 3228 M10758 GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 59/128 Gene Ontology BP GO:0006661 0.619773518108409 0.721024416080517 3185 2794.54545454545 2989 0.0841548859542361 1313 0.946863186450032 -0.946863186450032 -1 0.510547069656821 3183 3233 3333 2850 2928 1313 2903 3137 2989 3086 1785 3229 M14335 GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 10/39 Gene Ontology BP GO:0051350 0.727994862001774 0.810765206110395 3380 2750.81818181818 2989 0.111621746682362 1597 1.01405746558881 -1.01405746558881 -1 0.350680421868377 3376 3107 2029 2989 3407 1597 2147 4263 3754 1703 1887 3230 M10270 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 7/25 Gene Ontology BP GO:0044550 0.214139132665174 0.322775948981753 3575 2815 2990 0.0238095238095238 1680 0.460317779660509 -0.428761131404998 -1 0.85809205945013 3575 2035 3560 2247 2329 3254 3113 2948 1680 2990 3234 3231 M13590 GO_SULFUR_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSPORT.html The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/34 Gene Ontology BP GO:0072348 0.33296556889208 0.452829272514917 4345 3021.72727272727 2990 0.0396825396825397 1412 1.34349992948527 1.34349992948527 1 1.75463187541567 4341 3117 4099 2990 2655 3838 2289 2165 2156 1412 4177 3232 M15290 GO_RESPONSE_TO_EPINEPHRINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPINEPHRINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 7/29 Gene Ontology BP GO:0071871 0.577888589487761 0.685172809242001 2110 3042.81818181818 2990 0.0826338537880904 1915 0.321930392902215 0.413280862120569 1 0.200651331528879 2110 3029 4381 3195 2978 2350 2990 1915 3826 4229 2468 3233 M13097 GO_PROTEIN_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_STABILIZATION.html Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. 83/182 Gene Ontology BP GO:0050821 0.277210163959196 0.394448909366395 3570 2924.63636363636 2991 0.0290811955697972 749 0.862565180064786 -0.674350887224881 -1 1.3227886258897 3569 2991 3192 4144 2985 749 4378 2385 3813 2857 1108 3234 M10601 GO_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 68/177 Gene Ontology BP GO:0010921 0.0839184282471183 0.158445571591463 4315 2839.27272727273 2992 0.00793650793650794 1075 2.18771116543902 2.18771116543902 1 6.64434666392995 4315 2992 2460 3144 2442 1360 3037 4356 1075 2595 3456 3235 M10069 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. 58/140 Gene Ontology BP GO:1903214 0.148979514120572 0.250892957584989 3725 2876.63636363636 2993 0.0145583579426951 478 0.953570946993889 -0.795561739762606 -1 2.17360983931139 3722 2993 3118 3458 3886 478 2566 4522 2708 2478 1714 3236 M10286 GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-4 production. 24/68 Gene Ontology BP GO:0032673 0.359766407842371 0.47986079621147 2840 3139.63636363636 2993 0.0397276915757226 1582 0.328427810128047 -0.296281344895663 -1 0.397540041139941 2836 4402 1582 4438 2117 2140 3973 3077 4185 2993 2793 3237 M15012 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 55/120 Gene Ontology BP GO:0071158 0.0123933119207325 0.0473208447762837 2575 2775.18181818182 2993 0.00113306209814415 450 1.23031966226622 1.23031966226622 1 6.18762334597183 2575 4191 2060 3058 450 4209 3352 2993 2129 1736 3774 3238 M10246 GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. 57/204 Gene Ontology BP GO:1900544 0.00164700927262103 0.0112291689468127 3310 2690.36363636364 2994 0.000149840325860709 409 1.22743231134374 -1.29245240179828 -1 9.08368295583819 3310 2994 409 2421 1843 3209 3244 3030 2784 1763 4587 3239 M13998 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 57/204 Gene Ontology BP GO:0045981 0.00164700927262103 0.0112291689468127 2995 2688.09090909091 2994 0.000149840325860709 410 1.22743231134374 -1.29245240179828 -1 9.08368295583819 3311 2995 410 2422 1844 3210 3245 2994 2785 1765 4588 3240 M14421 GO_KETONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 17/38 Gene Ontology BP GO:0042181 0.0397003426749745 0.104476900749794 4585 2979.72727272727 2994 0.00367594530827136 857 0.35134538788585 -0.267430744229922 -1 1.3082824534059 4581 1544 2994 2934 857 3240 4462 2176 2237 4010 3742 3241 M14675 GO_URONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. 7/28 Gene Ontology BP GO:0006063 0.0765897756730953 0.158445571591463 2045 2449.81818181818 2994 0.00793650793650794 152 0.611481234588787 0.759365130362717 1 1.85714337660363 2045 152 4270 459 4292 3352 3794 1357 162 4071 2994 3242 M10295 GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 10/24 Gene Ontology BP GO:0009084 0.298735036746822 0.413174493778819 3845 2926 2995 0.0317460317460317 740 0.577018634726521 0.577018634726521 1 0.840770138674097 3841 740 2378 1855 2412 4581 3095 3949 1979 2995 4361 3243 M15880 GO_LIPID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_OXIDATION.html The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. 48/91 Gene Ontology BP GO:0034440 0.209390323539887 0.318336369415748 2290 2785 2996 0.0211326800260223 776 0.736186088956347 -0.736186088956347 -1 1.38915467786437 2286 2996 2371 3364 2483 776 4282 3437 3442 4370 828 3244 M10299 GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION.html The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 8/22 Gene Ontology BP GO:0086069 0.850784516478874 0.915455969875182 4415 3201 2997 0.173236321179394 1870 0.353079749388907 0.305647301459693 1 0.0514147088171983 4415 1870 3563 2446 4434 2546 2982 2441 3888 2997 3629 3245 M11285 GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. 11/27 Gene Ontology BP GO:0007176 0.612872089153805 0.714996864454816 3575 3057.63636363636 2997 0.0826559977687921 2177 0.664904966411386 -0.664904966411386 -1 0.367717270051929 3572 2177 2751 2737 2588 3493 4015 2242 3849 3213 2997 3246 M12017 GO_ORGANOPHOSPHATE_ESTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSPORT.html The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. 42/106 Gene Ontology BP GO:0015748 0.35943518917414 0.479556776820555 3000 3114.45454545455 2997 0.0396825396825397 1889 1.60847139939289 1.60847139939289 1 1.94862821295067 2997 3945 2612 3269 2927 4091 4231 1889 2187 2126 3985 3247 M10223 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein. 3/14 Gene Ontology BP GO:0042511 0.499697473010273 0.616390905203692 2945 2935.63636363636 2998 0.0669105702957013 1698 0.608132386476968 -0.190506714926829 -1 0.485089527855371 2942 3307 3555 3628 2733 3636 1698 1787 2998 2980 3028 3248 M10883 GO_ASSOCIATIVE_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASSOCIATIVE_LEARNING.html Learning by associating a stimulus (the cause) with a particular outcome (the effect). 33/113 Gene Ontology BP GO:0008306 0.161385165508919 0.258740097879113 4520 2980.72727272727 2998 0.0158730158730159 1351 1.34020151107259 1.34020151107259 1 2.98686942888091 4517 1963 3032 1975 4525 2808 3681 2998 1351 1758 4180 3249 M12745 GO_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. 19/43 Gene Ontology BP GO:0031440 0.417130224083872 0.537081696819155 3000 2872.18181818182 2998 0.0478873804292038 1272 0.220537343157438 -0.288245895291702 -1 0.225989479389074 2998 4459 3211 4531 2231 1272 1984 1609 4178 3565 1556 3250 M15613 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. 7/21 Gene Ontology BP GO:0060742 0.563103164257647 0.671242103118935 2565 3112.27272727273 2998 0.0794701203135673 1456 0.325965552461151 0.362222592662158 1 0.214204314650752 2690 3615 4431 3392 2562 2354 1456 2562 3860 4315 2998 3251 M10194 GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-beta production. 36/97 Gene Ontology BP GO:0032648 0.232850105696956 0.342669743502683 3570 3091.90909090909 3000 0.0238095238095238 1373 1.00891661677385 1.00891661677385 1 1.78127708001197 3570 1373 3000 2312 4587 4367 4268 2705 1841 1908 4080 3252 M16427 GO_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATED_EXOCYTOSIS.html A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. 122/351 Gene Ontology BP GO:0045055 0.133823717766552 0.231412857203017 2405 2987.36363636364 3002 0.0129757012807769 990 1.22883726602391 1.22883726602391 1 2.96479073314449 2401 2591 990 3362 3239 4482 3002 2326 3472 2841 4155 3253 M15567 GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of leukocyte degranulation. 24/56 Gene Ontology BP GO:0043300 0.336437667324102 0.457015824864192 2585 2866.36363636364 3003 0.036598252892 2071 0.905815316330878 -0.664904966411386 -1 1.16926683266863 2581 3003 2926 3172 2071 3411 2409 3247 3106 2420 3184 3254 M15831 GO_PEPTIDYL_ASPARAGINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ASPARAGINE_MODIFICATION.html The modification of peptidyl-asparagine. 18/40 Gene Ontology BP GO:0018196 0.466738071388703 0.580826820010117 3765 3337.27272727273 3003 0.0555555555555556 2352 0.715858725339802 0.715858725339802 1 0.641151524809978 3765 2352 2908 2865 2705 3003 4289 4163 2482 4362 3816 3255 M10344 GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. 9/23 Gene Ontology BP GO:0046337 0.473619393488039 0.588129137193091 3740 3006 3005 0.062157330828221 1746 0.388327826451266 0.483100197068426 1 0.339803708573564 3738 2033 3569 2597 2711 3921 1982 1746 3431 3005 4333 3256 M11446 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 22/63 Gene Ontology BP GO:0010719 0.0839184282471183 0.158445571591463 3975 2792.72727272727 3005 0.00793650793650794 335 1.82551842389692 1.82551842389692 1 5.54432296242545 3972 3005 2388 1837 4020 4065 4083 1583 335 1261 4171 3257 M12247 GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. 5/14 Gene Ontology BP GO:0045898 0.903115327580507 0.955380375018522 2475 3096.27272727273 3006 0.208181749501319 2235 0.18849372314238 0.266302413493048 1 0.0141836656591699 2474 2909 3876 3006 3962 2585 2235 2799 3664 3445 3104 3258 M10781 GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. 46/97 Gene Ontology BP GO:0031145 0.469115820837603 0.583316753119709 1110 2872.90909090909 3007 0.0559391665655426 1078 0.248423711015485 -0.253539183383214 -1 0.220746300746475 1109 4035 3351 3987 2939 1078 3007 2560 4315 3092 2129 3259 M11174 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. 428/988 Gene Ontology BP GO:0070647 0.0162962747078116 0.0574078933750904 2500 2892.63636363636 3007 0.00149256859624948 122 1.16592947857882 1.34843932285599 1 5.49238826274185 2496 4578 3492 4480 3591 122 2874 3007 3554 2933 692 3260 M13813 GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. 8/19 Gene Ontology BP GO:0060575 0.0397795522987416 0.104584632685763 4390 2722.36363636364 3007 0.00405101121253953 621 1.17453630946227 -1.29829314601985 -1 4.37155055180881 4386 1808 4135 1249 901 4071 4301 4099 1368 621 3007 3261 M16262 GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of cation channel activity. 48/127 Gene Ontology BP GO:2001257 0.161385165508919 0.258740097879113 4140 2938.81818181818 3007 0.0158730158730159 1631 1.06094041096732 -0.941440206989479 -1 2.36448806627379 4138 3494 2049 2641 2439 3007 3503 3039 1631 2275 4111 3262 M10453 GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. 42/140 Gene Ontology BP GO:0046634 0.235086756430685 0.345632618780137 2520 2814.81818181818 3009 0.02406860510286 1231 0.347721314017836 -0.335171877591947 -1 0.608978942915319 2516 3458 2071 4078 1822 1231 3009 4010 3621 3034 2113 3263 M10801 GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. 18/45 Gene Ontology BP GO:0040020 0.298735036746822 0.413174493778819 4475 2986.36363636364 3009 0.0317460317460317 1063 1.42750535851956 -1.38916827744188 -1 2.08000887000786 4471 3538 1990 3009 3871 3641 2434 4203 1958 1063 2672 3264 M13001 GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. 17/48 Gene Ontology BP GO:2000171 0.741791600042591 0.823365622519184 4120 3048.18181818182 3009 0.115815778396447 2020 0.361388162445325 -0.303733118290971 -1 0.115787321134074 4116 3009 2334 3888 2813 2092 2655 3599 3380 3624 2020 3265 M14552 GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER.html The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. 50/91 Gene Ontology BP GO:0006890 0.0312531182291119 0.0888026012024226 455 2252.09090909091 3009 0.00288237587654757 183 0.862559895960135 -0.862559895960135 -1 3.44299555487555 453 3708 3009 3602 3123 183 809 1202 4099 4044 541 3266 M12195 GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. 13/31 Gene Ontology BP GO:0070193 0.139554362719183 0.239626814388005 1800 2757.72727272727 3010 0.0135711467151768 461 0.262271699656772 -0.268222551146172 -1 0.617697238802537 1796 3573 3039 3010 2886 461 2156 4218 4289 3432 1475 3267 M16344 GO_FOLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 11/20 Gene Ontology BP GO:0046655 0.0839184282471183 0.158445571591463 3925 2571.72727272727 3010 0.00793650793650794 165 0.964916235402726 -0.810865129405406 -1 2.93056874725372 3922 1550 1355 1514 3281 3881 3657 3010 165 1823 4131 3268 M16464 GO_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLATION.html The covalent attachment of a mannose residue to a substrate molecule. 16/31 Gene Ontology BP GO:0097502 0.0658914175482645 0.148511578483783 1250 2273.36363636364 3010 0.00617743996496628 279 0.241707200211761 -0.237897544133456 -1 0.759893719463087 1250 3600 3335 3820 3010 279 593 794 3181 4510 635 3269 M10638 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. 129/330 Gene Ontology BP GO:0050688 0.597318307603006 0.701403364238937 3380 3280.90909090909 3011 0.0793650793650794 2295 1.16585524954904 1.2820135027605 1 0.681652851974789 3378 3772 2730 4237 2932 2295 3921 3011 2882 2552 4380 3270 M13541 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 59/147 Gene Ontology BP GO:0010522 0.075387472573729 0.158445571591463 3015 2558.54545454545 3011 0.00710017548411514 1001 1.32743501821078 1.47351154115841 1 4.03158267600214 3011 3138 1086 2359 1168 4263 3142 3365 1001 1845 3766 3271 M14746 GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. 15/50 Gene Ontology BP GO:0046426 0.0839184282471183 0.158445571591463 4525 2873.72727272727 3013 0.00793650793650794 531 1.15211368821794 -0.781628281319039 -1 3.49911033116638 4522 3013 2172 1438 3890 3549 4574 1901 531 2081 3940 3272 M10078 GO_MITOTIC_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CYTOKINESIS.html A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. 19/56 Gene Ontology BP GO:0000281 0.723286298598859 0.807652305049183 3015 2999.90909090909 3014 0.110234597140276 1532 0.349149995402775 -0.368106085596625 -1 0.122956890080047 3014 3954 1668 3956 3747 1532 2591 3329 4339 2948 1921 3273 M10262 GO_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 112/205 Gene Ontology BP GO:0010212 0.597318307603006 0.701403364238937 4295 3160.36363636364 3014 0.0793650793650794 1653 1.8833201318665 1.8833201318665 1 1.10114059158875 4293 3492 1653 3014 2568 2664 4390 3211 2900 2666 3913 3274 M15099 GO_NEGATIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STAT_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of STAT cascade. 15/50 Gene Ontology BP GO:1904893 0.0839184282471183 0.158445571591463 4525 2874.63636363636 3014 0.00793650793650794 532 1.15211368821794 -0.781628281319039 -1 3.49911033116638 4523 3014 2173 1439 3891 3550 4575 1900 532 2083 3941 3275 M11677 GO_REFLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REFLEX.html An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. 8/41 Gene Ontology BP GO:0060004 0.0360532752480038 0.0971534283090433 2980 2937.36363636364 3015 0.00366519179491031 621 0.457204717351333 0.413917211786054 1 1.75723936866656 2977 2687 3788 2871 4146 3015 4143 621 1179 3312 3572 3276 M15764 GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. 162/617 Gene Ontology BP GO:0002768 0.415320710913563 0.535202348257472 4585 3295.45454545455 3015 0.0476190476190476 1502 1.36972672541585 1.49383792005822 1 1.41150423047529 4584 4386 2466 4109 2394 1502 4501 4265 2458 2570 3015 3277 M10251 GO_REGULATION_OF_VESICLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_FUSION.html Any process that modulates the frequency, rate or extent of vesicle fusion. 31/71 Gene Ontology BP GO:0031338 0.616441766596529 0.718408414233856 2165 2846.09090909091 3016 0.0834282180564232 1523 1.12330469101083 -1.12330469101083 -1 0.612414831114816 2161 3977 3016 3417 4060 1523 3880 1924 3122 2553 1674 3278 M15340 GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. 131/336 Gene Ontology BP GO:0002218 0.63389956273523 0.731410454716618 3760 3158.27272727273 3016 0.0873015873015873 2173 1.18199903029656 1.18199903029656 1 0.609464344632863 3759 3587 2888 3910 3016 2355 3273 2173 2997 2758 4025 3279 M11832 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS.html The somatic process that results in the generation of sequence diversity of immunoglobulins. 13/29 Gene Ontology BP GO:0016445 0.597318307603006 0.701403364238937 3080 3118.36363636364 3017 0.0793650793650794 2552 0.847293883868049 0.847293883868049 1 0.495396227418876 3076 3017 3171 2627 3572 2883 4358 2863 2831 3352 2552 3280 M13964 GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. 9/36 Gene Ontology BP GO:0042430 0.478675516477372 0.594089928629896 3405 3054.45454545455 3017 0.0630620886780946 1610 1.03069309216194 -1.03069309216194 -1 0.884767136032026 2821 3404 4167 3780 2400 2339 3017 3404 4075 1610 2582 3281 M16685 GO_GLYCOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. 9/26 Gene Ontology BP GO:0016137 0.0626576602959071 0.143593048743286 3720 3083.90909090909 3017 0.00644978091813521 1118 0.371404137943092 -0.353199486622002 -1 1.18826363146969 3720 2034 4605 2863 1118 3116 4365 1890 2631 4564 3017 3282 M14809 GO_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 77/173 Gene Ontology BP GO:0071156 0.00731171849556903 0.032548714261675 3025 2823.45454545455 3021 0.000666921156956596 316 1.23031966226622 1.23031966226622 1 6.9465999793218 3021 3799 2384 3245 316 3403 3823 2620 1909 2277 4261 3283 M13923 GO_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. 13/54 Gene Ontology BP GO:0055078 0.199268649250204 0.306460529469592 3645 2381.09090909091 3024 0.02 290 1.12880629604804 -0.998542506531935 -1 2.20076256931253 3641 290 1931 407 4269 3247 3394 3455 1653 881 3024 3284 M10426 GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. 41/93 Gene Ontology BP GO:0036498 0.013876373407976 0.0517059722876905 1935 2435.72727272727 3025 0.00126951623614301 110 0.852246096011289 0.852246096011289 1 4.16167632013545 1935 3274 3373 3188 4616 110 1420 1790 3739 3025 323 3285 M16773 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. 2/23 Gene Ontology BP GO:0014857 0.391280061007178 0.512761310543699 3535 3173.9 3025 0.0536617548411853 1671 0.520701758660192 -0.811082979924083 -1 0.573351793451793 3532 1671 4617 NA 2300 2838 3604 2539 2908 4588 3142 3286 M10430 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. 13/45 Gene Ontology BP GO:0045956 0.415320710913563 0.535202348257472 3725 3094.27272727273 3026 0.0476190476190476 2451 0.354562533387781 0.335341267768358 1 0.365376907947335 2782 2645 2599 3520 2798 3722 3724 3162 2451 3026 3608 3287 M10902 GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any neuron projection extension that is involved in neuron projection guidance. 5/17 Gene Ontology BP GO:1902284 0.632427457617131 0.731410454716618 3010 3071 3027 0.0952380952380952 1182 1.98900160281705 1.98900160281705 1 1.02557237984642 3007 3199 3655 2869 4139 3771 3027 2356 2999 1182 3577 3288 M12174 GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of striated muscle contraction. 51/141 Gene Ontology BP GO:0006942 0.303454700624731 0.418704361070023 3985 2714.54545454545 3027 0.0323402661483472 647 1.28173956653876 -1.28773460801601 -1 1.83952249274395 3981 3315 1219 2705 3027 1600 4175 3831 2242 647 3118 3289 M10212 GO_VIRAL_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_BUDDING.html A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. 16/25 Gene Ontology BP GO:0046755 0.320740483207309 0.439184497849703 2155 3259.09090909091 3028 0.0345483678622099 912 0.151798174961264 0.167880613453619 1 0.20590704717121 2154 4564 3028 4412 3566 2840 912 4216 4609 2978 2571 3290 M11804 GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE.html The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. 5/17 Gene Ontology BP GO:0048846 0.632427457617131 0.731410454716618 3010 3086.45454545455 3028 0.0952380952380952 1193 1.98900160281705 1.98900160281705 1 1.02557237984642 3008 3200 3809 2870 4140 3772 3028 2353 3000 1193 3578 3291 M10580 GO_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. 8/22 Gene Ontology BP GO:0046209 0.00761739339436448 0.0335874240551133 3775 2475.63636363636 3029 0.000764363117025467 344 1.31505585488108 1.31505585488108 1 7.35693381610462 3773 573 3607 1250 344 3054 4542 3391 2176 1493 3029 3292 M15397 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein. 23/68 Gene Ontology BP GO:0042516 0.361760669448159 0.481552404887558 4475 2819.54545454545 3029 0.04 531 0.671837249370926 -0.671837249370926 -1 0.809316940881674 4473 531 1447 1096 3029 2117 4183 3984 2830 4259 3066 3293 M10438 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 7/40 Gene Ontology BP GO:0046189 0.488166112997999 0.604898655631094 1730 2844 3030 0.0647818997574499 1641 0.484612591315199 -0.520290557681683 -1 0.401596793832189 1730 3161 3584 3105 2415 2436 2936 3503 3743 3030 1641 3294 M14130 GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of anion transmembrane transport. 16/44 Gene Ontology BP GO:1903959 0.441637446903292 0.560558410599231 4000 3102 3031 0.0515981564945074 1985 0.323933304008257 -0.269823140233991 -1 0.30909504637615 3998 2601 3085 2921 2281 1985 4436 3790 3031 3928 2066 3295 M14676 GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. 6/23 Gene Ontology BP GO:1902259 0.147859119791321 0.249186894080256 3480 3024.18181818182 3031 0.0158730158730159 1302 1.13975148755868 -1.13975148755868 -1 2.61081765228146 3480 2585 4271 2041 1875 4627 3031 4570 1302 1332 4152 3296 M13523 GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. 3/19 Gene Ontology BP GO:0006704 0.0963164802338003 0.177037774238137 1290 2625.72727272727 3032 0.0100764953448735 510 0.348151974406257 0.348151974406257 1 0.993701282266117 1287 2473 4091 3032 3681 1181 510 4073 3631 3763 1161 3297 M16854 GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY.html Any process that modulates the activity of the enzyme protein phosphatase type 2A. 10/25 Gene Ontology BP GO:0034047 0.437744190543466 0.556377299943419 3720 2838.90909090909 3032 0.0509988846298814 1113 0.23690854949908 -0.224351684600827 -1 0.228980528530642 3718 2791 3241 3226 2302 1581 1113 1963 3652 4609 3032 3298 M10312 GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE.html Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. 41/108 Gene Ontology BP GO:0035019 0.35943518917414 0.479556776820555 3035 3046.90909090909 3033 0.0396825396825397 2281 1.31394404283802 1.31394404283802 1 1.59181470868983 3033 2736 2281 2577 3663 4223 3284 3169 2312 2678 3560 3299 M16959 GO_FRUCTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRUCTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. 7/26 Gene Ontology BP GO:0006000 0.0765897756730953 0.158445571591463 3150 2736.36363636364 3034 0.00793650793650794 469 0.601990035937887 -0.305228869020707 -1 1.82831744423617 3146 747 4641 1314 1737 4615 3034 2159 469 4639 3599 3300 M16138 GO_DEFINITIVE_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFINITIVE_HEMOPOIESIS.html A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. 8/21 Gene Ontology BP GO:0060216 0.264826730432136 0.380914036368156 3035 3027.27272727273 3035 0.0302964828846234 1530 1.08918898596586 1.08918898596586 1 1.73302088868264 3035 2232 4516 2257 1956 4153 4428 2322 3465 1530 3406 3301 M11389 GO_RELAXATION_OF_CARDIAC_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_CARDIAC_MUSCLE.html The process in which the extent of cardiac muscle contraction is reduced. 14/30 Gene Ontology BP GO:0055119 0.514011397665828 0.627050688219243 4610 3009.45454545455 3036 0.0634920634920635 1698 1.38933387508025 1.38933387508025 1 1.06896116889214 4610 1702 1698 3036 3722 3315 4138 2338 2623 2010 3912 3302 M10313 GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. 20/55 Gene Ontology BP GO:0031122 0.369601633533564 0.490302966998954 3275 3086.09090909091 3038 0.0410782064536706 1510 0.244642815828021 -0.266677256383823 -1 0.287441937962735 3273 4173 2843 3845 4202 1624 3038 1510 4403 3000 2036 3303 M14249 GO_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOR_SIGNALING.html Any process that modulates the frequency, rate or extent of TOR signaling. 45/108 Gene Ontology BP GO:0032006 0.667434366415499 0.758975695142582 2915 3230.72727272727 3038 0.0952380952380952 2182 1.2942703797537 1.2942703797537 1 0.588420806848946 2913 3832 2731 3562 3584 3842 4150 2737 3038 2182 2967 3304 M15713 GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-2 production. 27/66 Gene Ontology BP GO:0032663 0.161385165508919 0.258740097879113 3040 3012.90909090909 3038 0.0158730158730159 1346 1.48034281358945 1.48034281358945 1 3.2991984098421 3038 3175 1346 3110 2934 4195 3004 4398 1620 2501 3821 3305 M10522 GO_RESPONSE_TO_MUSCLE_STRETCH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_STRETCH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. 12/33 Gene Ontology BP GO:0035994 0.0445231059577823 0.113023937103326 2515 2647.09090909091 3040 0.00413186730905246 660 0.653874098340854 0.653874098340854 1 2.35002875977248 2512 2858 2125 3050 3130 3170 2308 660 3074 3040 3191 3306 M10577 GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. 12/18 Gene Ontology BP GO:0008535 0.852002335096789 0.916388400438239 2990 2881.63636363636 3040 0.159440184495695 1703 0.228749077254807 -0.238615383426236 -1 0.0329260535942625 2990 1703 3346 3524 3040 2010 2337 3334 3786 3053 2575 3307 M13217 GO_SPERM_EGG_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_EGG_RECOGNITION.html The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. 18/76 Gene Ontology BP GO:0035036 0.232491431022006 0.342669743502683 3255 2882 3040 0.0237680408161784 661 0.375895559523225 -0.293606968510949 -1 0.663656573212209 3255 3247 2068 3040 4363 661 2935 4023 2939 3674 1497 3308 M16089 GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. 68/204 Gene Ontology BP GO:0002698 0.557443745451391 0.666249592815201 3120 3162.72727272727 3040 0.0714285714285714 2096 0.962027907638543 0.962027907638543 1 0.644024644077193 3116 3040 2096 2954 4485 3441 3978 2103 2772 2598 4207 3309 M10256 GO_CARBOHYDRATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORT.html The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. 48/126 Gene Ontology BP GO:0008643 0.39539244968595 0.516837596816404 2595 2877.90909090909 3041 0.0447127957090122 1289 0.857297301609549 -0.717301207645577 -1 0.932791165912155 2594 1521 1289 1693 3041 4418 3670 3222 3566 2987 3656 3310 M11381 GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 12/20 Gene Ontology BP GO:0090335 0.729585238528223 0.811757551518461 2505 3114.18181818182 3041 0.112095208610622 2069 0.255979586808612 0.319460721213452 1 0.0880064481854421 2501 3638 3041 3563 2795 3423 2069 2735 4306 3239 2946 3311 M13463 GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 9/39 Gene Ontology BP GO:0086012 0.275742742869669 0.392721949430635 1760 2827.45454545455 3041 0.0317460317460317 1429 1.38933387508025 1.38933387508025 1 2.14066529967705 1756 2137 4079 3312 4235 3609 3886 1429 2011 1607 3041 3312 M15717 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. 58/166 Gene Ontology BP GO:0045638 0.0852532769774812 0.160190596926931 4625 2847.18181818182 3042 0.00806800998164781 1234 1.29644110978073 1.29644110978073 1 3.91404124777306 4621 3042 1412 3143 1234 3394 3840 2095 2306 2787 3445 3313 M14071 GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 47/90 Gene Ontology BP GO:0071479 0.161385165508919 0.258740097879113 4290 3110.27272727273 3043 0.0158730158730159 1601 1.7026876054589 1.7026876054589 1 3.79473199643953 4286 3043 2399 2379 3409 2776 4115 3976 1601 2263 3966 3314 M12146 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. 40/127 Gene Ontology BP GO:0001910 0.2757368243517 0.392721949430635 2525 2718.90909090909 3044 0.0289014413912361 1462 0.395743378963783 -0.273672192944446 -1 0.60975560586542 2523 3044 1684 3185 1923 3119 1462 2161 3643 3423 3741 3315 M16045 GO_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 667/1589 Gene Ontology BP GO:0033043 0.0590762556314409 0.137903999445339 4065 2835.90909090909 3044 0.00607081562634107 405 1.12329026054357 1.34937660353259 1 3.66869244423849 4063 3585 4500 3044 1093 405 3899 4165 2131 2774 1536 3316 M11417 GO_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELINATION.html Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 25/53 Gene Ontology BP GO:0031641 0.192576837807519 0.299141605199167 1465 2735.63636363636 3045 0.0192582695399367 688 0.293920622876582 0.370488215756773 1 0.584750575368304 1465 4549 2812 3512 3045 3259 688 2245 3422 3246 1849 3317 M15519 GO_CELLULAR_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. 10/17 Gene Ontology BP GO:0006878 0.43766110973417 0.556377299943419 3705 3052.36363636364 3045 0.0509861375227166 1712 1.03069309216194 -1.03069309216194 -1 0.99620148633551 3702 1983 3045 2559 2270 3285 4019 3856 2946 1712 4199 3318 M10560 GO_REGULATION_OF_PROSTAGLANDIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROSTAGLANDIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. 10/18 Gene Ontology BP GO:0032306 0.171577279430536 0.272329291412019 3235 3149.72727272727 3046 0.0169663965179641 1130 0.328537220208977 -0.22882037740559 -1 0.704478466831033 3233 2975 3003 3008 4216 3615 4359 1130 2326 3046 3736 3319 M12417 GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 16/29 Gene Ontology BP GO:0045978 0.161385165508919 0.258740097879113 4395 3211.90909090909 3046 0.0158730158730159 1610 0.387829687593514 0.274872143808533 1 0.864345121048181 4395 2640 2649 2798 3046 3822 3013 3962 1610 3482 3914 3320 M14998 GO_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 33/99 Gene Ontology BP GO:0051225 0.868336809368846 0.930246378841613 3135 3159.90909090909 3046 0.168329481139405 2041 0.67676793331447 -0.67676793331447 -1 0.08066859192329 3133 3046 2394 3037 4378 2041 3820 2422 3535 4152 2801 3321 M16094 GO_SERTOLI_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. 16/26 Gene Ontology BP GO:0060008 0.316928819818432 0.434840576364355 3640 3003.72727272727 3046 0.0340571078295786 1653 0.50491279453589 -0.50491279453589 -1 0.69316402953672 3639 1653 2130 2405 2035 2602 4254 3383 3046 4421 3473 3322 M13830 GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. 16/29 Gene Ontology BP GO:1903579 0.161385165508919 0.258740097879113 4400 3247.54545454545 3047 0.0158730158730159 1611 0.387829687593514 0.274872143808533 1 0.864345121048181 4396 2641 2650 2799 3047 3823 3014 3982 1611 3845 3915 3323 M14083 GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of plasma membrane organization. 60/137 Gene Ontology BP GO:1903729 0.144509618891141 0.246132854186195 3050 3071.36363636364 3047 0.0140889386678914 1514 1.27686276702898 1.15561871920577 1 2.95085447569269 3047 3377 1778 2571 1514 3989 3753 3974 2842 2510 4430 3324 M11729 GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. 46/110 Gene Ontology BP GO:0033238 0.0893232217890043 0.166290183948014 3340 2767.18181818182 3048 0.00847003842945278 1258 1.90919498657043 1.90919498657043 1 5.64636996454393 3337 1835 3307 3219 1258 1760 3777 4635 1546 2717 3048 3325 M12908 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. 21/56 Gene Ontology BP GO:1901021 0.667434366415499 0.758975695142582 3880 3083.09090909091 3048 0.0952380952380952 1399 1.02153487267164 -0.743128926420273 -1 0.464425658932187 3877 3536 2151 2687 3173 1399 4269 4494 3048 2326 2954 3326 M12244 GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE.html Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. 9/12 Gene Ontology BP GO:0048875 0.147859119791321 0.249186894080256 3050 2898.09090909091 3049 0.0158730158730159 1117 1.23435683890907 -1.23435683890907 -1 2.82752921091402 4467 1244 3874 1117 4632 4242 3049 3046 1272 1596 3340 3327 M15117 GO_EPITHELIAL_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MORPHOGENESIS.html The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. 28/69 Gene Ontology BP GO:0003382 0.0160483197078103 0.0568362688050061 3410 2377.63636363636 3050 0.00146969062990481 262 1.47541621458515 -0.995312132263088 -1 6.97463895712604 3409 397 631 262 4584 4240 3837 3050 317 865 4562 3328 M15231 GO_ISOPRENOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 10/33 Gene Ontology BP GO:0008299 0.0839184282471183 0.158445571591463 2940 2955.27272727273 3053 0.00793650793650794 536 0.436149678500902 0.323418914797885 1 1.32463997386517 2936 3479 1985 2725 4082 3346 2565 3053 536 4216 3585 3329 M10983 GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. 8/17 Gene Ontology BP GO:1903504 0.33296556889208 0.452829272514917 4265 2735.45454545455 3054 0.0396825396825397 1247 0.330655618043974 -0.309061407438133 -1 0.431841397452323 4265 1247 3667 1698 2253 3138 3054 2062 2209 3130 3367 3330 M16965 GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. 13/42 Gene Ontology BP GO:0048025 0.327001288286418 0.44681194276452 1565 2636.45454545455 3054 0.0353607468881991 849 0.280388983722355 -0.325358881899308 -1 0.372375732822367 1563 3357 3054 3380 3100 849 2225 1550 4078 4640 1205 3331 M10587 GO_PROSTATE_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a prostate gland are generated and organized. 10/37 Gene Ontology BP GO:0060512 0.512376746863008 0.627050688219243 3160 3102.45454545455 3055 0.0632061368602071 1243 0.408314087191778 -0.285414948897193 -1 0.314159117239447 3158 2936 2134 2980 4506 2759 1243 4575 3107 3055 3674 3332 M15165 GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. 8/17 Gene Ontology BP GO:0090266 0.33296556889208 0.452829272514917 4270 2900.63636363636 3055 0.0396825396825397 1248 0.330655618043974 -0.309061407438133 -1 0.431841397452323 4266 1248 4365 1699 2254 3139 3055 2105 2210 4198 3368 3333 M14410 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 16/50 Gene Ontology BP GO:0045078 0.232850105696956 0.342669743502683 3550 2951 3056 0.0238095238095238 1767 1.29644110978073 1.29644110978073 1 2.28891148792151 3546 3056 2841 3139 3748 1767 3300 4601 1820 2119 2524 3334 M15237 GO_MITOCHONDRIAL_GENOME_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_GENOME_MAINTENANCE.html The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. 19/31 Gene Ontology BP GO:0000002 0.374101817681013 0.494999925760314 3060 2870.90909090909 3056 0.041702543429957 1234 0.239462913585881 -0.233728386242684 -1 0.27759217855962 3056 3716 3175 3973 2145 1234 1357 2412 4292 4219 2001 3335 M11768 GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 68/154 Gene Ontology BP GO:0042177 0.297385254083304 0.413174493778819 3880 2986 3058 0.0315767544788494 784 1.07499160642574 1.20853851282603 1 1.56636335068197 3880 4161 3014 3506 4459 784 2826 3058 3342 2597 1219 3336 M13744 GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 13/57 Gene Ontology BP GO:2000514 0.434680766240665 0.553618343503925 3900 3165.54545454545 3058 0.0505299912849336 1342 0.471331053937647 0.492575614187533 1 0.459420738071409 3898 3016 1342 3279 3058 4565 2752 1811 2796 3824 4480 3337 M11308 GO_REGULATION_OF_HEAT_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEAT_GENERATION.html Any process that modulates the rate or extent of heat generation. 5/18 Gene Ontology BP GO:0031650 0.172676926102173 0.273724468382516 2510 3167.54545454545 3060 0.0187774651675908 1174 0.515367567985199 0.732268841134983 1 1.10075513037016 2507 2950 3727 2923 4203 4101 3022 1174 3957 3219 3060 3338 M12136 GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 10/22 Gene Ontology BP GO:0002082 0.698152987361708 0.785443256680497 3060 3201 3060 0.103174603174603 1686 1.03069309216194 -1.03069309216194 -1 0.410346508824381 3060 2862 2961 3341 4306 2928 4322 4071 3071 1686 2603 3339 M12372 GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 29/55 Gene Ontology BP GO:0006220 0.638274182275685 0.735909368836853 2330 3100.09090909091 3060 0.0882984724398334 1926 0.839258219059802 -1.0296882537552 -1 0.424255731362296 2328 4009 3060 3881 2625 1926 3256 3668 4082 2532 2734 3340 M11591 GO_IRON_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_TRANSPORT.html The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/73 Gene Ontology BP GO:0006826 0.667434366415499 0.758975695142582 3065 2841 3061 0.0952380952380952 1401 0.816302209950325 -0.816302209950325 -1 0.371119676723486 2212 3142 2880 3257 4418 1401 3064 2740 3061 3297 1779 3341 M16770 GO_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METABOLIC_PROCESS.html Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. 418/1006 Gene Ontology BP GO:0006259 0.631597981536719 0.731410454716618 1125 3220.63636363636 3061 0.0867814442537351 1122 0.740441340747431 -0.643179695930235 -1 0.381787619814175 1122 4643 3485 4573 4509 1534 3061 3025 4291 2936 2248 3342 M16828 GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION.html Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. 17/26 Gene Ontology BP GO:2000615 0.380525021987136 0.502210823503773 3065 3142.90909090909 3061 0.0426007787213831 1374 0.300392455405588 0.261345605872001 1 0.341061653450708 2732 3956 2511 4083 2156 2704 1374 3061 4327 4603 3065 3343 M11297 GO_CARBOHYDRATE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHORYLATION.html The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. 10/24 Gene Ontology BP GO:0046835 0.615697466890062 0.717721149578348 3205 2915.18181818182 3062 0.0832666678306493 1863 0.342586900894349 0.32342357693092 1 0.18731559170945 3201 1863 2932 2867 3596 3608 2430 1921 3370 3217 3062 3344 M13808 GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. 40/130 Gene Ontology BP GO:0017158 0.466738071388703 0.580826820010117 3325 2785 3062 0.0555555555555556 1288 0.400534484832639 -0.454376742296307 -1 0.358734602992698 3325 3139 1832 3673 3062 1288 3094 2418 2558 3837 2409 3345 M14077 GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. 13/40 Gene Ontology BP GO:0046460 0.514011397665828 0.627050688219243 3190 3064.72727272727 3062 0.0634920634920635 1507 1.27675999939789 -1.27675999939789 -1 0.982346206200682 3186 3062 1507 2984 4095 3473 2499 4121 2647 1949 4189 3346 M16095 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. 17/46 Gene Ontology BP GO:1903170 0.161385165508919 0.258740097879113 4305 3018.81818181818 3062 0.0158730158730159 1044 1.34463734700163 1.34463734700163 1 2.99675545170607 4305 3429 2553 2534 2558 3062 4026 3703 1373 1044 4620 3347 M11412 GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. 765/2173 Gene Ontology BP GO:0051172 0.0268454162129615 0.0801564421072542 3490 2919.63636363636 3063 0.00271753440477697 728 1.24849349867218 1.39884970482998 1 5.19431719078409 3487 3700 3740 4173 728 1552 2902 3632 2685 2454 3063 3348 M13885 GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE.html A process of chromosome organization that is involved in a meiotic cell cycle. 20/56 Gene Ontology BP GO:0070192 0.215318078484111 0.324164020234023 1175 2734 3063 0.0218021697509365 628 0.282364340449791 -0.295140525673774 -1 0.524366294356233 1175 3284 2916 3087 4208 628 1907 3063 4273 3863 1670 3349 M16472 GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 13/40 Gene Ontology BP GO:0046463 0.514011397665828 0.627050688219243 3190 3066.63636363636 3063 0.0634920634920635 1508 1.27675999939789 -1.27675999939789 -1 0.982346206200682 3187 3063 1508 2985 4096 3474 2500 4116 2648 1966 4190 3350 M12961 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 20/47 Gene Ontology BP GO:1902235 0.564249733483538 0.672091203838909 3080 2867.36363636364 3064 0.0727359473538801 1335 0.522536967759313 0.522536967759313 1 0.342289874110519 3078 1541 3064 1998 2948 4083 1335 2406 3790 3616 3682 3351 M14295 GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 12/34 Gene Ontology BP GO:0055094 0.161385165508919 0.258740097879113 4200 3074.09090909091 3064 0.0158730158730159 1377 0.633042077535849 0.633042077535849 1 1.41084308056682 4200 3064 1377 2217 2125 4289 2865 3547 1634 3973 4524 3352 M14369 GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. 9/19 Gene Ontology BP GO:0036499 0.0131722981378855 0.0497227481741481 4235 3139.63636363636 3064 0.00132510350428965 478 0.522536967759313 0.522536967759313 1 2.58533556713979 3054 3922 4231 3064 478 4232 1151 3044 4333 3991 3036 3353 M13721 GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. 97/242 Gene Ontology BP GO:0045017 0.570477062485574 0.678986157682779 3985 3154.27272727273 3065 0.0739485336897048 1914 1.11181159292396 -1.11181159292396 -1 0.709589359567315 3983 3309 3065 3574 2499 1914 4455 3816 3041 2879 2162 3354 M14509 GO_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. 21/82 Gene Ontology BP GO:0046530 0.232850105696956 0.342669743502683 3780 2878.45454545455 3065 0.0238095238095238 1232 1.19951281013891 1.40369885952815 1 2.11778123225603 3779 1936 2018 2226 3679 3131 4278 3065 1702 1232 4617 3355 M15754 GO_RESPONSE_TO_MERCURY_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MERCURY_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. 7/20 Gene Ontology BP GO:0046689 0.440158033420519 0.559139192659773 3990 2873.36363636364 3066 0.0563595586199448 904 0.428137797624726 0.362106419738634 1 0.410315473302092 3990 904 4453 1605 3063 1382 3066 1681 3955 4345 3163 3356 M10200 GO_N_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_GLYCAN_PROCESSING.html The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. 11/20 Gene Ontology BP GO:0006491 0.0005324788357775 0.00511863195551746 3785 2624.81818181818 3068 4.84188871294925e-05 62 0.715858725339802 0.715858725339802 1 6.22487259681529 3781 561 2004 1116 62 4501 3241 3422 3068 2974 4143 3357 M12321 GO_REGULATION_OF_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. 10/20 Gene Ontology BP GO:0090231 0.586772521300215 0.693227688650611 3715 2957.72727272727 3068 0.077198889473482 1342 0.307472781078405 -0.315736949444208 -1 0.185716232472288 3714 1342 3068 2076 4318 2763 3451 1870 3497 3465 2971 3358 M14062 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 31/74 Gene Ontology BP GO:0010524 0.0031022765380123 0.0178881977064173 3760 2885.72727272727 3068 0.000282423617604245 184 1.00108534376399 1.13006355243585 1 6.64016651296239 3757 3463 1821 2911 184 3068 4052 3144 2281 2561 4501 3359 M10663 GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. 15/30 Gene Ontology BP GO:0006656 0.514011397665828 0.627050688219243 2935 3310.63636363636 3069 0.0634920634920635 1825 0.327881371665463 0.280357845814831 1 0.25227374097203 2932 3504 2902 3722 4628 2810 1825 4578 2658 3069 3789 3360 M12536 GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of T cell death by apoptotic process. 23/41 Gene Ontology BP GO:0070232 0.154273931580039 0.257752380110155 2280 3061.81818181818 3069 0.0151172753644409 1025 1.46584243959724 1.46584243959724 1 3.27612409490362 2277 4292 1025 4358 3069 3039 2521 3278 3917 2390 3514 3361 M12265 GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. 24/72 Gene Ontology BP GO:1903792 0.502363277241814 0.618857175970746 3070 2939.09090909091 3070 0.0614734049232638 1591 0.436997670743261 0.493967573974307 1 0.345703684344037 3070 1591 1603 2968 2900 4305 3140 1736 3339 3451 4227 3362 M12615 GO_CHLORIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_TRANSPORT.html The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/116 Gene Ontology BP GO:0006821 0.0839184282471183 0.158445571591463 3990 2746.27272727273 3070 0.00793650793650794 234 2.05390742852465 2.05390742852465 1 6.23796833252276 3987 2494 1906 2242 3619 3070 3389 3421 234 1295 4552 3363 M13303 GO_TRANSEPITHELIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSEPITHELIAL_TRANSPORT.html The directed movement of a substance from one side of an epithelium to the other. 6/18 Gene Ontology BP GO:0070633 0.29822597227852 0.413174493778819 1085 2736.90909090909 3071 0.034794630799134 1082 1.03855172572717 1.03855172572717 1 1.51326703505054 1082 3926 4048 4054 3435 1822 2046 3071 4215 1322 1085 3364 M16043 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 51/151 Gene Ontology BP GO:0032729 0.444611256182647 0.563716565389413 3075 3131.18181818182 3071 0.0520584662797286 1354 1.38114177468899 1.38114177468899 1 1.30508496596731 3071 3651 1354 4088 3009 4431 2258 3086 2871 2349 4275 3365 M16527 GO_RESPONSE_TO_REDOX_STATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REDOX_STATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. 19/54 Gene Ontology BP GO:0051775 0.212187061709096 0.321640394226358 4615 3089.09090909091 3071 0.021447977256615 1754 1.29644110978073 1.29644110978073 1 2.42426652359568 4614 2926 2726 3150 1754 3071 4236 2714 3097 2254 3438 3366 M10677 GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of dendritic cell differentiation. 18/50 Gene Ontology BP GO:2001198 0.889736891916416 0.945752836347967 2440 3286.54545454545 3072 0.181632822371087 2258 0.227860518397309 -0.240857877185049 -1 0.0209504106522261 2440 4413 2380 4554 3128 2258 2808 3731 4581 3072 2787 3367 M13799 GO_PROTEIN_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION.html The process in which one or more ubiquitin groups are added to a protein. 303/718 Gene Ontology BP GO:0016567 0.0019442360199647 0.0126429801690421 2830 2915.81818181818 3072 0.000176905123185312 34 1.2133814121813 1.34656551650037 1 8.74249157239636 2829 4485 3484 4510 4126 34 2971 3072 3273 2930 360 3368 M12565 GO_ORGANELLE_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FISSION.html The creation of two or more organelles by division of one organelle. 284/735 Gene Ontology BP GO:0048285 0.664162405264885 0.758888347628615 2105 3192.36363636364 3073 0.0944324608977653 1385 1.14518571914155 -0.808913397424817 -1 0.520858957639997 2101 4433 2893 4481 3563 1385 3644 3073 4247 2918 2378 3369 M13768 GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 40/88 Gene Ontology BP GO:0072527 0.377195324358939 0.498524876458455 3115 3255 3073 0.0421340949791881 2014 0.839258219059802 -1.0296882537552 -1 0.963074524193014 3111 4125 3073 4428 2150 2014 3003 4140 4223 2668 2870 3370 M16760 GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 121/280 Gene Ontology BP GO:0009895 0.121456838686089 0.213872933109773 3920 2940.36363636364 3073 0.011702823143986 1198 1.19844501643177 1.46755018078994 1 3.04718715952723 3916 4120 1916 3762 1417 1198 4073 3193 2963 2713 3073 3371 M14406 GO_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_GENE_SILENCING.html The inactivation of gene expression by a posttranscriptional mechanism. 21/58 Gene Ontology BP GO:0016441 0.0254202811586736 0.0777000430676246 1230 2254.18181818182 3074 0.00233807684086317 231 0.25403144321 -0.258764375033691 -1 1.06992376377282 1229 3282 3225 3791 3074 231 459 1406 3812 4005 282 3372 M16115 GO_MITOCHONDRION_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_DISTRIBUTION.html Any process that establishes the spatial arrangement of mitochondria between and within cells. 7/17 Gene Ontology BP GO:0048311 0.275742742869669 0.392721949430635 3660 3102.63636363636 3074 0.0317460317460317 1431 1.67949129323189 1.67949129323189 1 2.58773560270018 3659 3074 4512 2665 2407 4640 1737 4533 1952 1431 3519 3373 M12973 GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. 6/13 Gene Ontology BP GO:0060576 0.0252988970230963 0.0773799597353333 3690 2533 3075 0.00255916135223664 502 1.17453630946227 -1.29829314601985 -1 4.95487763744257 3688 3075 3987 1401 706 3868 3980 3469 732 502 2455 3374 M14939 GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. 6/15 Gene Ontology BP GO:0043558 0.088616921312855 0.165306695723417 4275 3195.90909090909 3076 0.00923627776924544 1299 0.239862777202042 -0.260449349669157 -1 0.711730388624443 4272 2722 4321 3076 1299 2122 2796 4544 2376 4132 3495 3375 M16056 GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. 53/124 Gene Ontology BP GO:0048524 0.505037208336784 0.621656351619217 2635 3081.45454545455 3076 0.0619329781760124 1231 0.30900235869146 0.286280603651328 1 0.242149247058211 2633 3087 2953 3776 2484 3774 1231 2619 3855 4408 3076 3376 M15554 GO_RENAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_ABSORPTION.html A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). 9/35 Gene Ontology BP GO:0070293 0.00503474905502883 0.025271718770269 1785 2781.72727272727 3077 0.000504619247537687 109 0.430344584302053 0.495985440183539 1 2.60932272805442 1785 2977 4421 3077 3504 1294 109 4021 3872 4303 1236 3377 M12468 GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 8/24 Gene Ontology BP GO:0010758 0.113044348463792 0.201715953081239 3550 2716.18181818182 3080 0.0119243641091852 1425 0.800508376728112 -0.800508376728112 -1 2.1126142358844 3548 1552 3913 1568 1425 2377 3449 3910 1560 3496 3080 3378 M11487 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. 59/102 Gene Ontology BP GO:0000070 0.841313218900594 0.909268453295032 1945 3176.72727272727 3082 0.154094426533014 1811 1.20238510924012 -0.674350887224881 -1 0.18853139799057 1945 4497 1992 4290 3789 1811 3316 3082 4447 2789 2986 3379 M12847 GO_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_VACUOLE.html A process in which a protein is transported to, or maintained at, a location in a vacuole. 35/61 Gene Ontology BP GO:0072665 0.582773236597703 0.689204314193361 4385 3221.36363636364 3082 0.076390528126111 2190 1.05669244556265 1.05669244556265 1 0.648390957912168 4381 2738 3082 2454 2529 2190 4506 4039 3578 2616 3322 3380 M15146 GO_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. 523/1375 Gene Ontology BP GO:0061024 0.171620828488384 0.272329291412019 3590 3086.18181818182 3082 0.0186522816664334 816 1.22604349935893 1.34288465489185 1 2.628990542703 3586 4242 4360 4228 1683 816 3082 3675 2684 2741 2851 3381 M10644 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process. 120/244 Gene Ontology BP GO:1903364 0.557443745451391 0.666249592815201 4310 3214.18181818182 3083 0.0714285714285714 1520 1.00525798097337 1.10763097381636 1 0.672964794752114 4309 3083 2972 2920 3198 1520 4452 3757 2782 2703 3660 3382 M15923 GO_CELLULAR_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. 10/14 Gene Ontology BP GO:0043482 0.298735036746822 0.413174493778819 3725 2828.27272727273 3083 0.0317460317460317 1239 0.94175740835774 0.94175740835774 1 1.37222865819941 3723 1239 3083 2069 2273 3151 1280 3311 2126 4379 4477 3383 M16896 GO_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. 10/14 Gene Ontology BP GO:0043476 0.298735036746822 0.413174493778819 3725 2852.09090909091 3084 0.0317460317460317 1240 0.94175740835774 0.94175740835774 1 1.37222865819941 3724 1240 3084 2070 2274 3152 1281 3320 2127 4623 4478 3384 M10750 GO_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION.html A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 33/59 Gene Ontology BP GO:0006635 0.144671844861221 0.246318802966869 1790 2543.45454545455 3085 0.0141059362731788 811 0.50491279453589 -0.50491279453589 -1 1.16623461375214 1786 3624 3097 3223 2490 811 4114 1042 3751 3085 955 3385 M14731 GO_BEHAVIORAL_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_COCAINE.html Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. 5/15 Gene Ontology BP GO:0048148 0.747184787071181 0.828361739821274 3890 3322.18181818182 3086 0.128474055108895 2216 0.474476115579623 0.532078945301426 1 0.147288393265009 3886 2766 4283 2618 4302 2448 2827 2216 4027 4085 3086 3386 M10766 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. 9/21 Gene Ontology BP GO:0043302 0.0287917932550549 0.0836547534938798 2625 2934.09090909091 3087 0.00291717760473126 754 0.250328146873612 0.253753972131581 1 1.02385386330035 2623 3665 3630 3591 754 2458 2006 3807 3698 3087 2956 3387 M13815 GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. 53/135 Gene Ontology BP GO:0046434 0.0816287163799644 0.158445571591463 4295 3205.54545454545 3087 0.00771134310226715 1209 1.1365216668259 -0.794526396855928 -1 3.45175545317353 4294 4034 2317 4307 1209 2739 3902 3087 3063 2382 3927 3388 M10906 GO_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_SECRETION.html The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. 15/51 Gene Ontology BP GO:0030073 0.466738071388703 0.580826820010117 3090 3096.81818181818 3088 0.0555555555555556 2059 1.7354036805309 1.7354036805309 1 1.55429650673807 3088 2818 2231 2922 3439 4608 3487 3265 2485 2059 3663 3389 M15861 GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an androgen binding to its receptor. 24/55 Gene Ontology BP GO:0030521 0.698152987361708 0.785443256680497 4395 3353.72727272727 3088 0.103174603174603 1942 1.31739699471586 1.31739699471586 1 0.524491006759535 4391 3467 1942 2654 2911 2833 4370 4387 3088 2422 4426 3390 M16153 GO_GLYCEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROL_TRANSPORT.html The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. 7/11 Gene Ontology BP GO:0015793 0.64680298709903 0.742881308914616 3705 3314 3088 0.098840423617321 1563 0.465098797662579 -0.480765718076512 -1 0.227883728718927 3701 2721 4519 2330 2965 3041 1563 3638 4461 4427 3088 3391 M10727 GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. 8/15 Gene Ontology BP GO:0045779 0.00234910507773169 0.0146471578788332 3630 2607 3089 0.000235159201110549 160 1.48034281358945 1.48034281358945 1 10.3068810117558 4531 1406 3626 1281 160 3627 3089 3283 1676 1495 4503 3392 M10843 GO_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. 17/41 Gene Ontology BP GO:0033233 0.00803263692587765 0.034920911279822 1500 2232.09090909091 3089 0.000732919679917307 147 0.289322051100513 -0.36680595321086 -1 1.60001042229313 1499 3567 3129 3089 4272 369 1265 330 3785 3101 147 3393 M13890 GO_OOCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. 13/45 Gene Ontology BP GO:0001556 0.21792975282065 0.327883293048049 3090 2920.63636363636 3089 0.0220985964471891 635 0.320669209278677 -0.362879470708747 -1 0.589469940994904 3089 3890 2526 3793 3497 635 2359 2832 4034 3864 1608 3394 M15663 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. 34/90 Gene Ontology BP GO:1901379 0.597318307603006 0.701403364238937 4410 2981.72727272727 3089 0.0793650793650794 1842 1.28127221255727 -1.28127221255727 -1 0.74913490178473 4406 2346 2131 2632 3089 3148 3721 3203 2880 1842 3401 3395 M11005 GO_APICAL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_ASSEMBLY.html The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. 35/65 Gene Ontology BP GO:0043297 0.139756294019567 0.239884832951146 2955 2771.18181818182 3090 0.0135921941716087 462 0.357099616936699 -0.344872787260506 -1 0.840400593617704 2955 3090 2515 3581 4579 462 2737 3132 3130 3137 1165 3396 M11510 GO_NEGATIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. 8/18 Gene Ontology BP GO:0046851 0.00234910507773169 0.0146471578788332 4535 2620.81818181818 3090 0.000235159201110549 161 1.48034281358945 1.48034281358945 1 10.3068810117558 4532 1407 3760 1282 161 3628 3090 3288 1677 1500 4504 3397 M10397 GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 85/214 Gene Ontology BP GO:0046488 0.0939952500305611 0.17373405489327 4015 3151.90909090909 3092 0.00893355923982167 1283 1.54284179130812 1.84083109373717 1 4.45151614949976 4015 2771 3092 2601 1283 3185 4391 4561 2215 2714 3843 3398 M11089 GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 175/351 Gene Ontology BP GO:0045732 0.242942354987955 0.355157857118726 4635 3032.90909090909 3092 0.0249840445552828 680 1.1173506854642 1.20648749527932 1 1.90678767163514 4632 2729 3139 3092 3487 680 4211 3483 2459 2646 2804 3399 M11809 GO_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 19/55 Gene Ontology BP GO:0035456 0.597318307603006 0.701403364238937 2270 2839.09090909091 3093 0.0793650793650794 1510 0.293370615303955 -0.256266506444152 -1 0.171528083379577 2269 3682 3093 3438 3490 1510 2463 3459 2853 3346 1627 3400 M12762 GO_MYELOID_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_ACTIVATION.html A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. 60/180 Gene Ontology BP GO:0002274 0.262299867915038 0.3783208429335 4050 3112.18181818182 3093 0.027277238718881 1889 0.980020203507056 0.975157604060794 1 1.57035734210469 4047 3271 2495 3093 1889 2693 4102 3606 2976 2794 3268 3401 M16660 GO_NUCLEAR_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 128/255 Gene Ontology BP GO:0098813 0.667363711794396 0.758975695142582 1180 3081 3093 0.0952206224227039 1177 1.20238510924012 -0.674350887224881 -1 0.546646533192398 1177 4357 2203 4305 3903 1616 3181 3093 4486 2905 2665 3402 M10131 GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 30/65 Gene Ontology BP GO:0050854 0.291827818502993 0.410139707445999 2460 2960 3094 0.0308828921498412 1196 0.361662653558412 0.366645858280738 1 0.531371636321989 2457 4398 1196 4337 4626 3094 1828 1421 3132 2960 3111 3403 M10441 GO_DENDRITIC_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_MIGRATION.html The movement of a dendritic cell within or between different tissues and organs of the body. 7/48 Gene Ontology BP GO:0036336 0.0765897756730953 0.158445571591463 2640 2974.36363636364 3094 0.00793650793650794 442 0.403518837092786 -0.0518514834780721 -1 1.22553611331806 2636 4634 3585 4534 3473 3099 1371 2818 442 3032 3094 3404 M10471 GO_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 26/70 Gene Ontology BP GO:0051602 0.477261127792822 0.592492892070073 2900 3137.27272727273 3094 0.0572652258591004 1457 1.0019014339942 -1.0019014339942 -1 0.864497752813058 2898 3094 1457 2754 2334 4547 3533 3677 3670 2459 4087 3405 M11871 GO_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROAUTOPHAGY.html The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. 182/417 Gene Ontology BP GO:0016236 0.0661393986274943 0.148846276550945 3615 2947.72727272727 3095 0.00620142772862617 282 0.92813765614798 -0.670911486173297 -1 2.9144909618354 3611 3971 3089 4576 3095 282 3039 3252 3271 2903 1336 3406 M15604 GO_HEME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. 15/21 Gene Ontology BP GO:0006783 0.181748231854558 0.284990557413276 3095 2817 3095 0.0180697666408176 1339 0.231021531387536 -0.268771176110212 -1 0.478069748842663 3095 3601 3320 3490 1663 1570 1339 2454 4096 4313 2046 3407 M12905 GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT.html The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 7/35 Gene Ontology BP GO:0007603 0.386880896041789 0.507712832199556 2180 3054.90909090909 3096 0.0477423180589992 1406 1.02401096892853 1.02401096892853 1 1.14425517308353 2178 2580 3978 3667 2230 3825 3171 4542 3096 1406 2931 3408 M14423 GO_I_KAPPAB_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_PHOSPHORYLATION.html The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 20/54 Gene Ontology BP GO:0007252 0.466738071388703 0.580826820010117 4645 3165.45454545455 3097 0.0555555555555556 2297 1.29644110978073 1.29644110978073 1 1.16114418256259 4642 3053 3197 3097 3312 3821 3441 2419 2531 2297 3010 3409 M10838 GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). 9/33 Gene Ontology BP GO:0042744 0.00842651812685676 0.0362020544295597 4225 2643.45454545455 3099 0.000845864249451682 150 0.517097801786586 0.314196398411585 1 2.8289436718215 4223 150 3645 2071 365 3886 2008 3758 1421 3099 4452 3410 M11024 GO_HEME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_METABOLIC_PROCESS.html The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. 21/37 Gene Ontology BP GO:0042168 0.113630491969032 0.202528358622731 2680 2771.27272727273 3099 0.0109056756881934 1377 0.344249850867006 0.409766420693324 1 0.906225592265085 2676 1437 3099 1666 1377 3956 3443 4041 2123 3143 3523 3411 M12505 GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of T cell tolerance induction. 18/53 Gene Ontology BP GO:0002664 0.67342245207731 0.764661395205417 2745 3080.90909090909 3099 0.0967313474640913 1700 0.338541907909962 -0.319604544341044 -1 0.149747826219012 2745 3955 1700 3839 2686 2114 3278 3099 4296 3507 2671 3412 M14022 GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that increases the extent to which blood vessels can be pervaded by fluid. 6/13 Gene Ontology BP GO:0043117 0.598881260040338 0.702350515374411 4425 3170.72727272727 3100 0.0873015873015873 1294 0.404579795627036 -0.501626224791706 -1 0.235649900587104 4421 1294 4172 1755 4068 3027 3100 2415 2938 3903 3785 3413 M16738 GO_V_D_J_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_V_D_J_RECOMBINATION.html The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). 7/17 Gene Ontology BP GO:0033151 0.614554019657285 0.716748131943927 2200 3379.36363636364 3100 0.0909320384892003 2198 0.244577779737009 -0.304503108472503 -1 0.13427430562981 2198 4182 4613 4245 2639 2205 2909 3100 3956 4578 2548 3414 M10050 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. 22/50 Gene Ontology BP GO:0048008 0.232850105696956 0.342669743502683 4560 2889.18181818182 3101 0.0238095238095238 787 2.46711003640163 2.46711003640163 1 4.35576784929965 4556 1644 1762 787 3273 4610 3101 4478 1713 2351 3506 3415 M13858 GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. 31/69 Gene Ontology BP GO:0006687 0.0839184282471183 0.158445571591463 3105 2356.18181818182 3101 0.00793650793650794 393 1.44876578490595 1.44876578490595 1 4.40007906971267 3101 393 1427 524 3370 4158 4372 3843 512 949 3269 3416 M10676 GO_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 17/35 Gene Ontology BP GO:0051125 0.253469711157199 0.367309572067064 3665 3104.09090909091 3103 0.0262244687003325 1874 0.764161110170704 -0.764161110170704 -1 1.26168001709243 3665 3568 3033 2795 1874 3162 3865 2695 3103 3071 3314 3417 M15814 GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 14/56 Gene Ontology BP GO:0007215 0.466738071388703 0.580826820010117 2975 3291.81818181818 3103 0.0555555555555556 2032 1.38933387508025 1.38933387508025 1 1.24434263502787 2974 4018 2208 4315 3023 4211 3103 4351 2525 2032 3450 3418 M11873 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE.html A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 12/19 Gene Ontology BP GO:0033539 0.233459836550279 0.343458181591554 1770 2691.36363636364 3104 0.0238800835172191 691 0.279396958866524 -0.311865438310266 -1 0.492226429259216 1767 3104 2942 3123 3629 691 4555 1554 3992 3359 889 3419 M12014 GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. 14/25 Gene Ontology BP GO:0046621 0.848119119612076 0.914707798457345 3675 3088.54545454545 3104 0.157458713633223 1831 0.276078857241067 -0.285416054688942 -1 0.0405741108553799 3673 3358 2791 3503 3104 1831 2066 2865 4413 3393 2977 3420 M11527 GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. 3/16 Gene Ontology BP GO:2000400 0.574876051179194 0.682472387017387 3035 3015.18181818182 3106 0.0819812381536202 2145 0.666981813933896 0.818515179957674 1 0.420055479009969 3031 2145 3762 3106 2583 2722 2208 3185 3590 3280 3555 3421 M15036 GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. 3/16 Gene Ontology BP GO:0033089 0.574876051179194 0.682472387017387 3035 3148.90909090909 3107 0.0819812381536202 2146 0.666981813933896 0.818515179957674 1 0.420055479009969 3032 2146 4337 3107 2584 2723 2209 3190 3591 4163 3556 3422 M16221 GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA.html The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. 14/60 Gene Ontology BP GO:0007339 0.149620203857137 0.251424758055986 3110 3009.45454545455 3107 0.0146258254462619 484 0.245211819967658 -0.244022287231517 -1 0.558090245329308 3107 3755 2905 3854 3969 484 1999 2727 4452 4445 1407 3423 M16359 GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosyl compound. 63/135 Gene Ontology BP GO:1901659 0.0957151218270662 0.176071834644639 1745 2948.27272727273 3107 0.00910473833021632 1259 0.648828184364399 0.648828184364399 1 1.85774827521036 1742 3939 3420 4146 1291 1259 2853 3107 4050 4480 2144 3424 M11357 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. 17/69 Gene Ontology BP GO:0002716 0.88374674095326 0.941138449294111 2740 3199.72727272727 3108 0.177687616295918 2056 0.279394202027486 -0.243562335974582 -1 0.0279413429592423 2738 4332 2312 4085 3108 2056 2968 3369 4297 3235 2697 3425 M12625 GO_COBALAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COBALAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. 9/42 Gene Ontology BP GO:0009235 0.724168549565168 0.80836813975179 2825 3045.36363636364 3108 0.120847170251126 1704 0.442218817893365 -0.348032882434913 -1 0.155086227731343 2822 2716 3939 3108 3931 1908 1704 3218 3721 3541 2891 3426 M13443 GO_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAPPING.html The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. 20/43 Gene Ontology BP GO:0036260 0.456767503931806 0.575827184565673 1960 2682.45454545455 3108 0.053963713487404 1057 0.21369112206868 -0.263837517452766 -1 0.194435670308992 1956 3352 3418 3231 3617 1057 2221 2215 3108 3741 1591 3427 M10979 GO_NOTCH_RECEPTOR_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_RECEPTOR_PROCESSING.html The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. 9/20 Gene Ontology BP GO:0007220 0.262357364792304 0.3783208429335 3780 2635.72727272727 3109 0.0299712614764065 659 0.485503102590204 -0.352095878081709 -1 0.77795677982076 3777 659 3664 1816 1947 1708 3274 3109 3429 3127 2483 3428 M14261 GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 13/37 Gene Ontology BP GO:0009190 0.163101158226755 0.260591423828914 2135 2825.45454545455 3109 0.0160562539102982 1042 0.438293010075602 0.501379569924572 1 0.971659899003559 2134 2310 1042 3202 3148 3109 1529 3372 4199 3961 3074 3429 M14394 GO_7_METHYLGUANOSINE_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_7_METHYLGUANOSINE_RNA_CAPPING.html The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. 20/43 Gene Ontology BP GO:0009452 0.456767503931806 0.575827184565673 1960 2721.09090909091 3109 0.053963713487404 1058 0.21369112206868 -0.263837517452766 -1 0.194435670308992 1957 3353 3419 3232 3618 1058 2222 2373 3109 3999 1592 3430 M15795 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY.html Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. 17/69 Gene Ontology BP GO:0045953 0.88374674095326 0.941138449294111 2740 3301.90909090909 3109 0.177687616295918 2057 0.279394202027486 -0.243562335974582 -1 0.0279413429592423 2739 4333 2313 4086 3109 2057 2969 3364 4298 4355 2698 3431 M10881 GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. 8/20 Gene Ontology BP GO:0000380 0.538777067439394 0.651107178529143 2870 3428 3110 0.0744687451946332 2506 0.0988708377980665 -0.0567548592925657 -1 0.0699357204790682 2867 4348 3651 4394 2506 2885 2828 3069 4623 3110 3427 3432 M12111 GO_INNER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 15/63 Gene Ontology BP GO:0036159 0.514011397665828 0.627050688219243 4185 3174.63636363636 3110 0.0634920634920635 2068 1.29644110978073 1.29644110978073 1 0.997488961402132 4184 3784 2977 3302 3272 2573 4457 2540 2654 2068 3110 3433 M15572 GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION.html Any process that modulates the frequency, rate or extent of cytoplasmic translation. 8/17 Gene Ontology BP GO:2000765 0.0522513956347409 0.126487606846769 3200 3107.18181818182 3111 0.005352225245614 1029 0.743128926420273 -0.743128926420273 -1 2.53293783667779 3196 3111 4426 2875 1029 2828 3518 4199 2801 4310 1886 3434 M11207 GO_PROTEASOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ASSEMBLY.html The aggregation, arrangement and bonding together of a mature, active proteasome complex. 10/17 Gene Ontology BP GO:0043248 0.698152987361708 0.785443256680497 2540 2944.36363636364 3113 0.103174603174603 1680 0.251893922969047 -0.269388009854772 -1 0.100285713111569 2537 3789 3295 4070 4357 1680 2391 2053 3113 3190 1913 3435 M14217 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. 9/16 Gene Ontology BP GO:1904814 0.632427457617131 0.731410454716618 3115 3134.36363636364 3113 0.0952380952380952 1612 1.33403223803043 -1.33403223803043 -1 0.687855965070666 3113 3109 4207 3357 3203 2605 3884 3515 3023 1612 2850 3436 M15206 GO_STEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 22/70 Gene Ontology BP GO:0016126 0.466738071388703 0.580826820010117 3105 3432.63636363636 3113 0.0555555555555556 2205 0.73426504557095 0.73426504557095 1 0.657636956736502 3102 2811 2205 3113 2609 4624 4461 3823 2605 4211 4195 3437 M10132 GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION.html Any process that set the alignment of spindle relative to other cellular structures. 18/33 Gene Ontology BP GO:0051294 0.865412014258462 0.927755248719011 3350 3243.45454545455 3114 0.166666666666667 2694 0.889829409089437 -0.889829409089437 -1 0.10999834185193 3347 3248 3078 3736 3114 2836 4288 2694 3435 2961 2941 3438 M12650 GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. 8/11 Gene Ontology BP GO:0070129 0.0531267387838196 0.128138934115987 1215 2337.81818181818 3114 0.00544412938423837 359 0.209661456410531 -0.209661456410531 -1 0.710143175087315 1213 3114 3945 3589 4341 359 391 724 3862 3546 632 3439 M13864 GO_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MIGRATION.html The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. 63/181 Gene Ontology BP GO:0001764 0.17383015312619 0.274334942544153 3115 2938.63636363636 3114 0.0172097278096985 1489 1.51219857869234 1.51219857869234 1 3.22429724092912 3114 2876 1489 3656 1626 2185 3958 3681 3667 2537 3536 3440 M16069 GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that modulates the frequency, rate or extent of the viral entry into the host cell. 21/69 Gene Ontology BP GO:0046596 0.434738849970991 0.553618343503925 3350 3099.36363636364 3114 0.0505388601814608 1285 0.395478524542086 -0.429426312684384 -1 0.38548496668147 3348 2383 2129 2776 4164 2299 3114 4360 3822 4413 1285 3441 M12840 GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to another neuron across a synapse. 22/105 Gene Ontology BP GO:0007270 0.0472190183564201 0.117806503078376 3115 2915.63636363636 3115 0.00438763893888838 674 1.11640253263892 1.11640253263892 1 3.93608639128123 3115 3468 2697 3844 4312 3075 3579 674 2663 1268 3377 3442 M14712 GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT.html The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. 6/16 Gene Ontology BP GO:0072531 0.457860014908013 0.577047787518432 3260 2997 3115 0.0593866378449928 1483 0.293431981065549 -0.2955658853306 -1 0.265966889546952 3256 2796 4279 3115 4015 1850 2779 1713 3601 4080 1483 3443 M13502 GO_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SUMOYLATION.html The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. 71/158 Gene Ontology BP GO:0016925 0.585440321347679 0.691829832531757 2560 3179.18181818182 3116 0.0769288295971802 1264 0.237839762692553 -0.24445357730071 -1 0.144448692725484 2558 4604 3116 4479 3833 1264 2382 2293 4510 3758 2174 3444 M13532 GO_TETRAPYRROLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 32/86 Gene Ontology BP GO:0033013 0.28785336818433 0.406314497069646 1960 3026.81818181818 3116 0.0303896996971212 1932 0.355799870936791 -0.280759266229204 -1 0.528253854730839 4177 1932 2749 2513 1958 1957 3439 3904 3116 3766 3784 3445 M14819 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. 29/70 Gene Ontology BP GO:1903201 0.378189242637149 0.499554097742328 2955 3062.18181818182 3116 0.0422731626192563 1524 0.325848079120286 -0.246629286015093 -1 0.372812806458053 2951 3209 2796 3403 3116 3728 2707 1524 2675 4104 3471 3446 M15179 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 13/18 Gene Ontology BP GO:0045717 0.268860540460632 0.385998605243882 2800 3165.72727272727 3116 0.0280668747072056 1904 0.73426504557095 0.73426504557095 1 1.15224688541049 2798 3505 2853 3096 1904 3746 1937 3604 4062 4202 3116 3447 M12858 GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 10/38 Gene Ontology BP GO:0051354 0.821472604707141 0.893440455295211 2850 3016.54545454545 3117 0.144986110335182 1973 0.376521976689409 -0.322671204567895 -1 0.0699377581752355 2846 2538 2343 3182 3920 1973 3117 4160 3421 3588 2094 3448 M13212 GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. 9/26 Gene Ontology BP GO:0030859 0.52340095663996 0.635617084269422 3870 3094.18181818182 3118 0.0714285714285714 1604 1.46584243959724 1.46584243959724 1 1.09503855540275 3866 2399 4033 2064 3118 4149 2189 3739 2745 1604 4130 3449 M15174 GO_VISUAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VISUAL_BEHAVIOR.html The behavior of an organism in response to a visual stimulus. 26/78 Gene Ontology BP GO:0007632 0.232850105696956 0.342669743502683 4245 3099.36363636364 3118 0.0238095238095238 1808 1.38933387508025 1.38933387508025 1 2.45291686853711 4243 2886 3125 3252 4118 3118 3426 2574 1808 2472 3071 3450 M15703 GO_ZINC_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. 7/27 Gene Ontology BP GO:0055069 0.0839491936495799 0.158445571591463 2600 2851.81818181818 3118 0.00873001521396601 1276 1.03069309216194 -1.03069309216194 -1 3.13034111468863 2599 3118 4443 3365 1276 2483 4064 3608 3308 1426 1680 3451 M11493 GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 68/180 Gene Ontology BP GO:0051282 0.159107573730778 0.258740097879113 3120 3021.72727272727 3119 0.0156303346027584 1573 1.14413454014118 1.34463734700163 1 2.54990048302864 3119 4006 1733 3616 1573 3857 3642 2347 2303 2596 4447 3452 M16042 GO_MULTICELLULAR_ORGANISM_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_REPRODUCTION.html The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. 355/1283 Gene Ontology BP GO:0032504 0.0522255396644841 0.126487606846769 3625 2613.90909090909 3119 0.00486437732440394 921 1.43782596798663 1.65361673321785 1 4.90079670904165 3624 4081 921 3627 984 1402 3749 3119 2274 1275 3697 3453 M10443 GO_LYSOSOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_TRANSPORT.html The directed movement of substances into, out of or within a lysosome. 50/101 Gene Ontology BP GO:0007041 0.361760669448159 0.481552404887558 3380 2658.36363636364 3120 0.04 511 1.27823424936525 1.27823424936525 1 1.53980243504273 3379 511 3120 1098 3835 1214 3520 4079 3155 2742 2589 3454 M11058 GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a type 2 immune response. 14/45 Gene Ontology BP GO:0002828 0.157542071748673 0.258740097879113 2495 2922.18181818182 3121 0.0154638739924955 1542 0.462382722777456 0.44567256730901 1 1.03049937456501 2492 2675 1542 3679 1569 3121 2077 4278 3825 3154 3732 3455 M11930 GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. 6/29 Gene Ontology BP GO:0045947 0.456646139318207 0.575827184565673 2220 2942.27272727273 3121 0.0591762422222989 1858 0.223790145263952 0.240511630335376 1 0.203624682595589 2216 3121 3827 3370 2360 3514 1858 2516 4156 3375 2052 3456 M12981 GO_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. 108/204 Gene Ontology BP GO:0000819 0.666882831419194 0.758975695142582 1180 3136.36363636364 3121 0.0951017907470805 1176 1.20238510924012 -0.674350887224881 -1 0.546646533192398 1176 4535 2100 4363 3876 1902 3267 3121 4488 2886 2786 3457 M10931 GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 30/61 Gene Ontology BP GO:0043647 0.372208107220379 0.493297188040371 1995 3143.72727272727 3122 0.04143932214492 998 0.219028496327494 0.20074737851355 1 0.255148203282772 1992 4400 2876 4455 4180 2667 998 3745 4527 3122 1619 3458 M12241 GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS.html The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. 134/275 Gene Ontology BP GO:0090305 0.459691260203623 0.579198513195501 2960 3237.90909090909 3122 0.0544277320476741 1065 1.23851416875867 1.33831365292312 1 1.11499431912016 2959 4277 3430 4330 4575 1065 3122 3969 2780 2765 2345 3459 M14419 GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/49 Gene Ontology BP GO:0032369 0.667434366415499 0.758975695142582 3125 3162.36363636364 3123 0.0952380952380952 1873 0.417225777971366 0.440947358845201 1 0.189685503583593 3123 2111 1873 2836 2972 4379 3230 3245 3030 4009 3978 3460 M15254 GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN.html The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. 30/58 Gene Ontology BP GO:0051220 0.792433998303041 0.868162117536814 3240 3133.90909090909 3123 0.13319123793957 1681 0.972406636028458 -0.644872453133905 -1 0.226630123439344 4469 3238 2996 3236 2979 1681 2892 3557 3758 2544 3123 3461 M13508 GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. 131/273 Gene Ontology BP GO:0045930 0.0905785659379679 0.168051790029106 3970 3134.72727272727 3124 0.00859437073028452 1269 1.30577915377795 1.42798520168239 1 3.83910743009521 3968 4593 2597 3869 1269 1718 3748 4341 3124 2229 3026 3462 M15867 GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 11/28 Gene Ontology BP GO:0048261 0.35943518917414 0.479556776820555 3625 3048.81818181818 3124 0.0396825396825397 777 1.20533937591405 -1.26395308557773 -1 1.46024251031238 3625 3720 2400 2098 3124 4580 2596 3851 2166 777 4600 3463 M16961 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. 17/23 Gene Ontology BP GO:0032703 0.161385165508919 0.258740097879113 3125 2883.90909090909 3124 0.0158730158730159 1292 1.48034281358945 1.48034281358945 1 3.2991984098421 3124 2600 1292 2211 3216 3943 3283 4487 1555 2165 3847 3464 M10962 GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. 10/28 Gene Ontology BP GO:0032780 0.809620807259773 0.883032513062515 4225 3233.09090909091 3125 0.139975423768368 2321 0.221317516803763 -0.192846964271453 -1 0.0453841464306995 4224 2824 3294 3091 2945 2321 2895 3501 4070 3125 3274 3465 M11232 GO_REGULATION_OF_RUFFLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RUFFLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of ruffle assembly. 16/35 Gene Ontology BP GO:1900027 0.638544624187403 0.73603840369963 2970 2966.36363636364 3125 0.0883604596545202 1473 0.330445501349126 -0.298616383124395 -1 0.166948907246768 2966 3055 2578 3125 3410 3227 1473 2888 3512 3194 3202 3466 M12901 GO_G1_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage. 45/99 Gene Ontology BP GO:0044783 0.21367438750617 0.322775948981753 4170 3313.72727272727 3125 0.0216160693210464 1756 1.18847832685675 -1.3261771808088 -1 2.21547778577079 4166 4194 2778 4092 1756 2459 4306 4475 3125 2179 2921 3467 M10494 GO_ENDOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. 40/73 Gene Ontology BP GO:0007032 0.667434366415499 0.758975695142582 4610 3308.63636363636 3126 0.0952380952380952 2051 1.74015150196074 1.74015150196074 1 0.791134037307483 4607 3622 2740 3126 2680 2373 4182 4112 3024 2051 3878 3468 M12575 GO_REGULATION_OF_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_SILENCING.html Any process that affects the rate, extent or location of chromatin silencing. 12/33 Gene Ontology BP GO:0031935 0.667434366415499 0.758975695142582 4245 3306.72727272727 3126 0.0952380952380952 1870 1.33403223803043 -1.33403223803043 -1 0.606497945213569 4244 3893 2878 3660 4031 2993 3984 2666 3029 1870 3126 3469 M15635 GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. 10/22 Gene Ontology BP GO:0000097 0.751985672431077 0.832094727620946 2090 3172.81818181818 3126 0.119047619047619 2090 0.32041308512064 -0.419978796528274 -1 0.0970886656383756 2090 3856 2833 3460 4547 2250 3126 2555 3195 4321 2668 3470 M12567 GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. 10/24 Gene Ontology BP GO:2000269 0.715613114820307 0.801010533295729 3125 2940.54545454545 3127 0.108019387465127 1622 1.45023161899474 1.45023161899474 1 0.530456019860246 3125 3664 2402 3135 3785 3793 1622 2842 3159 1692 3127 3471 M13155 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. 30/55 Gene Ontology BP GO:0034502 0.413664238494883 0.535202348257472 4140 3099.27272727273 3128 0.0473740702968407 1316 1.53222578464289 -1.33403223803043 -1 1.57895961067629 3079 3679 1316 3103 4137 2540 4137 3955 3372 1646 3128 3472 M13931 GO_REGULATION_OF_PROTEIN_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_STABILITY.html Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. 134/304 Gene Ontology BP GO:0031647 0.0178759567447146 0.0613891029332172 3210 2554 3128 0.00163844370539447 434 1.15068940558678 1.30946891170741 1 5.29340658615799 3210 2955 3284 3607 556 434 4011 3139 3128 2860 910 3473 M12496 GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. 26/74 Gene Ontology BP GO:1903307 0.227360261681125 0.340197774729443 2830 3177.36363636364 3129 0.0231765101195036 1799 0.313597305185631 0.292214845336562 1 0.557409705566061 2827 2884 3038 3421 1799 3129 3565 4432 2800 3503 3553 3474 M15236 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI.html The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. 46/82 Gene Ontology BP GO:0042147 0.273112864504324 0.391543201297339 3130 3084.63636363636 3129 0.0285821278979655 834 1.20346654016697 -0.956456561975776 -1 1.86024730572194 3129 3344 2991 2671 2383 4269 834 4135 3404 2227 4544 3475 M16197 GO_HISTONE_H3_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_ACETYLATION.html The modification of histone H3 by the addition of an acetyl group. 30/51 Gene Ontology BP GO:0043966 0.349992968154624 0.473351981107462 2170 3190.27272727273 3129 0.0384042162320983 1483 0.814201200647222 0.814201200647222 1 1.00386685938749 2170 4221 3119 4309 3965 3168 2185 1483 3129 4441 2903 3476 M10990 GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. 4/12 Gene Ontology BP GO:0090220 0.317700600998168 0.435770720955537 1970 2681.27272727273 3131 0.0375071790490426 876 0.25275811736631 -0.25275811736631 -1 0.346105893782405 1969 3337 3668 3079 3520 876 1240 3545 3614 3131 1515 3477 M11073 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. 8/18 Gene Ontology BP GO:0002204 0.0886079675154415 0.165306695723417 2555 2891.72727272727 3131 0.00923530440703999 878 0.847293883868049 0.847293883868049 1 2.5141241687702 2553 4025 3684 3131 3710 2521 1851 878 3249 3157 3050 3478 M10992 GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. 12/16 Gene Ontology BP GO:0045910 0.583763641640225 0.690199793260902 3080 3431.63636363636 3132 0.0765900568535068 2349 0.249132036952971 -0.245201593112432 -1 0.152275694759071 4297 4203 3076 4431 2531 2414 3790 2349 4446 3132 3079 3479 M13836 GO_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOTYPE_SWITCHING.html The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 8/18 Gene Ontology BP GO:0045190 0.0573196394790049 0.135368812869288 2555 2985.18181818182 3132 0.00588541409786507 749 0.847293883868049 0.847293883868049 1 2.79319858977515 2554 4026 4142 3132 3711 2522 1852 749 3250 3848 3051 3480 M15689 GO_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTOSIS.html A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells. 174/474 Gene Ontology BP GO:0006887 0.199243270277144 0.306460529469592 3560 3026.36363636364 3132 0.0199971763273585 1096 0.928978023330782 1.12043245539121 1 1.81116996652361 3557 3128 1096 3265 2057 3132 4304 2476 3227 2855 4193 3481 M14018 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE.html The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. 8/18 Gene Ontology BP GO:0002208 0.0505042668712096 0.123611655816039 2555 2990.36363636364 3133 0.00516901866208557 715 0.847293883868049 0.847293883868049 1 2.92010674720437 2555 4027 4171 3133 3712 2523 1853 715 3251 3902 3052 3482 M15067 GO_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that modulates the frequency, rate or extent of translational initiation. 42/99 Gene Ontology BP GO:0006446 0.393393162644907 0.514803961150029 1865 2875.72727272727 3133 0.0444260539356274 1194 0.253346454141218 0.306978516718036 1 0.277302794757358 1863 3591 3415 3801 2184 3484 1194 2115 3133 4171 2682 3483 M13691 GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that modulates the frequency, rate or extent of regulated secretory pathway. 66/188 Gene Ontology BP GO:1903305 0.298735036746822 0.413174493778819 4605 3168.63636363636 3135 0.0317460317460317 1900 0.905815316330878 -0.664904966411386 -1 1.31985766723767 4604 3135 2277 3576 2833 1900 4120 4242 2132 2817 3219 3484 M15870 GO_CELLULAR_MACROMOLECULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULE_LOCALIZATION.html Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 715/1626 Gene Ontology BP GO:0070727 0.0183567275175558 0.0623940599297304 3285 2809.90909090909 3135 0.00185101504829054 143 1.14779128231272 1.3142823006464 1 5.24935047443731 3281 3931 4470 3923 1791 143 3936 3135 2779 2795 725 3485 M15971 GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 15/23 Gene Ontology BP GO:0048011 0.466738071388703 0.580826820010117 4455 3413 3135 0.0555555555555556 2417 0.743128926420273 -0.743128926420273 -1 0.66557580070484 4451 3059 3135 2417 2754 2718 4197 4642 2554 4392 3224 3486 M11401 GO_CLATHRIN_COAT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_ASSEMBLY.html The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. 6/13 Gene Ontology BP GO:0048268 0.171376583243727 0.272207586077444 1690 2579.54545454545 3136 0.0186233507462172 782 0.347579616671664 -0.498232574543132 -1 0.745566980500239 1686 3409 3737 4049 3136 1079 1372 2452 3430 3243 782 3487 M12255 GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 11/18 Gene Ontology BP GO:0042559 0.779799596028643 0.857557916712693 2480 3035 3136 0.12852247378481 1646 0.233073341412594 -0.322376555803641 -1 0.0590423337141304 2476 3400 3136 4023 4099 1646 2184 3096 3483 3450 2392 3488 M16063 GO_PEPTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 9/24 Gene Ontology BP GO:0043171 0.386086746459241 0.506813899861537 2805 3199.27272727273 3137 0.0476190476190476 2136 0.392536441801741 0.546879739014044 1 0.439776665030946 2802 2136 4503 2174 4370 3787 2223 3317 2333 4410 3137 3489 M15376 GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT.html The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis. 17/38 Gene Ontology BP GO:0090662 0.415320710913563 0.535202348257472 4105 2989.18181818182 3138 0.0476190476190476 1680 1.09541946057391 -0.801505046067566 -1 1.12883042581145 4102 1941 3138 1680 4285 3143 3849 3341 2335 2157 2910 3490 M15438 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. 18/30 Gene Ontology BP GO:0033137 0.501529734490979 0.617994309246713 2095 3160.45454545455 3141 0.0613306013988648 1735 0.311722772893511 0.344508608377365 1 0.247317190846336 2092 4327 2743 4077 2880 3614 2542 1735 3344 4270 3141 3491 M10919 GO_CHROMOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION.html Any process in which a chromosome is transported to, or maintained in, a specific location. 40/72 Gene Ontology BP GO:0050000 0.629789915149775 0.731211446871819 3145 3373.72727272727 3143 0.0863749002977292 1331 0.234655178499363 -0.231522954212635 -1 0.121098567372426 3143 4611 2311 4596 3928 1331 3877 2793 4570 3120 2831 3492 M10151 GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION.html The acetylation of the N-terminal amino acid of proteins. 6/15 Gene Ontology BP GO:0006474 0.728593395928252 0.810897342842178 3145 3214.18181818182 3145 0.12226777945278 2197 0.201268771546184 -0.203100192100577 -1 0.0695485110965817 3145 2906 3544 3330 2853 2197 3927 3916 4208 2965 2365 3493 M13102 GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS.html Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 92/252 Gene Ontology BP GO:0010565 0.0460589755793929 0.115860574033061 4495 3044.18181818182 3145 0.0042775006588852 931 0.924414522023406 -1.01948926024963 -1 3.28457878816555 4495 1766 2969 3145 931 2030 4213 4564 3266 2871 3236 3494 M16040 GO_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_PHOSPHORYLATION.html The modification of histones by addition of phosphate groups. 18/59 Gene Ontology BP GO:0016572 0.85449807593031 0.918387631144544 4410 3396.72727272727 3145 0.160738776426373 1828 0.284665436775956 0.28691847464691 1 0.0399519609152375 2324 4407 1828 4505 4174 2900 2180 3040 4455 4406 3145 3495 M12462 GO_PROTEIN_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DESTABILIZATION.html Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. 21/51 Gene Ontology BP GO:0031648 0.295986553132058 0.413174493778819 4405 3139.27272727273 3146 0.0314016539446141 1914 0.318677246291252 -0.260774964130595 -1 0.464342564322647 4402 3281 2781 3047 1982 2863 3146 1914 3749 3493 3874 3496 M12935 GO_LEFT_RIGHT_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). 9/20 Gene Ontology BP GO:0070986 0.0516990803138381 0.125740612832452 4080 3048.54545454545 3147 0.0052942757863303 1022 0.544184141482052 -0.353163538318045 -1 1.86015275757656 4076 1945 3983 2663 1022 3147 3528 2736 2357 3608 4469 3497 M14001 GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the Notch signaling pathway. 34/96 Gene Ontology BP GO:0008593 0.491540005986702 0.608754400585824 3150 3147.36363636364 3149 0.0596358333120166 1407 1.70820157422404 1.70820157422404 1 1.39768809237537 3149 1780 1407 2912 3732 4145 2894 4237 3439 2607 4319 3498 M13840 GO_REGULATION_OF_EXOSOMAL_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOSOMAL_SECRETION.html Any process that modulates the frequency, rate or extent of exosomal secretion. 11/20 Gene Ontology BP GO:1903541 0.256686383197686 0.37139136091831 2975 3239.36363636364 3150 0.0266066572030524 1318 0.142163553256577 -0.162372078348664 -1 0.23213135447967 2971 4627 3150 4509 4634 1596 2552 1318 4606 3849 1821 3499 M12928 GO_PARENTAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARENTAL_BEHAVIOR.html A reproductive behavior in which a parent cares for and rears offspring. 4/16 Gene Ontology BP GO:0060746 0.464341697993272 0.580826820010117 1640 2882.54545454545 3151 0.0605173069496105 1218 0.343066810349373 0.343066810349373 1 0.307264269771702 1639 3673 3981 4057 3151 1675 1218 2308 4261 3605 2140 3500 M13499 GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 10/37 Gene Ontology BP GO:0061037 0.127593676746687 0.222295475097511 1700 2752.36363636364 3151 0.0123324153169396 544 0.283162830197775 0.31534868642342 1 0.701944532233467 1696 3853 3151 3840 2542 1376 544 4304 3787 3756 1427 3501 M14189 GO_DRUG_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORT.html The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/52 Gene Ontology BP GO:0015893 0.199268649250204 0.306460529469592 4465 2918.72727272727 3151 0.02 292 0.413388281334045 -0.425808139770957 -1 0.805957106379484 4465 292 2620 2290 3745 3286 2660 3151 2308 3942 3347 3502 M11212 GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. 30/66 Gene Ontology BP GO:0045806 0.667434366415499 0.758975695142582 4065 3091.18181818182 3152 0.0952380952380952 1645 1.20533937591405 -1.26395308557773 -1 0.54798964666207 4065 4094 1688 3277 4298 2428 3152 3240 3027 1645 3089 3503 M13719 GO_MALE_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS_I.html A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. 11/129 Gene Ontology BP GO:0007141 0.273570193004719 0.392032841395343 3155 2916.45454545455 3152 0.0286377053869088 738 0.299287961556841 -0.334704680860508 -1 0.462005001845826 3152 3186 2295 3692 2735 738 3674 2554 4502 3816 1737 3504 M13927 GO_MATERNAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_BEHAVIOR.html Female behaviors associated with the care and rearing of offspring. 4/16 Gene Ontology BP GO:0042711 0.464341697993272 0.580826820010117 1640 2924.45454545455 3152 0.0605173069496105 1219 0.343066810349373 0.343066810349373 1 0.307264269771702 1640 3674 4158 4058 3152 1676 1219 2312 4262 3877 2141 3505 M11057 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 6/14 Gene Ontology BP GO:0033147 0.143552393016559 0.245222134207463 3535 3049.63636363636 3153 0.0153767648960754 1092 0.24038883843208 -0.257161577848961 -1 0.55701225440884 3535 2945 3679 3281 2055 3048 3560 1092 4494 3153 2704 3506 M12262 GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 18/62 Gene Ontology BP GO:0045072 0.557443745451391 0.666249592815201 3400 3047.63636363636 3153 0.0714285714285714 1789 1.29644110978073 1.29644110978073 1 0.867895845560495 3400 3752 2675 3299 3554 1789 3153 4437 2774 2193 2498 3507 M10846 GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 66/144 Gene Ontology BP GO:0071482 0.0982167227377175 0.180031679301706 4490 3116.09090909091 3154 0.00935425211632979 1301 1.03739522091661 1.03739522091661 1 2.93227225022022 4488 4058 2092 4171 1301 2033 3060 3272 4077 2571 3154 3508 M11060 GO_3_UTR_MEDIATED_MRNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_UTR_MEDIATED_MRNA_STABILIZATION.html An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. 11/16 Gene Ontology BP GO:0070935 0.698152987361708 0.785443256680497 3845 3065 3155 0.103174603174603 1549 0.288483585882119 -0.222875916981823 -1 0.114853037328733 3844 1549 3257 2126 3235 1820 4531 4362 3082 3155 2754 3509 M16520 GO_ENDODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the endoderm. 6/16 Gene Ontology BP GO:0001711 0.278778842510594 0.39607410213485 2240 3198.90909090909 3155 0.0321526932972631 1998 0.425069848533209 0.440859125361541 1 0.648985554129473 2240 3794 4573 3239 1998 2711 2124 3155 3886 4520 2948 3510 M10780 GO_PROTEIN_N_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. 40/81 Gene Ontology BP GO:0006487 0.232850105696956 0.342669743502683 4435 3267.90909090909 3156 0.0238095238095238 1892 0.715858725339802 0.715858725339802 1 1.26387326635571 4434 2524 2999 3156 3413 2298 4350 3925 1892 3091 3865 3511 M12781 GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 254/577 Gene Ontology BP GO:0009896 0.19117049206325 0.29727752751794 4085 3154.27272727273 3156 0.0191030989979103 580 1.1040792634662 1.1595961949851 1 2.20792598358918 4081 3877 3156 4164 3389 580 4272 2573 2783 2700 3122 3512 M12782 GO_PHOSPHOLIPID_SCRAMBLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_SCRAMBLING.html The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). 8/21 Gene Ontology BP GO:0017121 0.291337573995365 0.410027388924062 1675 2801.45454545455 3156 0.033851373821423 902 0.436120057141489 0.523323217894493 1 0.640964839956508 1674 3156 3958 3167 4622 1560 902 2708 3357 3574 2138 3513 M16102 GO_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that modulates the frequency, rate or extent of muscle adaptation. 48/102 Gene Ontology BP GO:0043502 0.128072757635842 0.223046441749143 4380 3037.81818181818 3156 0.0123817345809973 975 1.66856634435063 -2.05264147871253 -1 4.1270042786668 4379 1959 975 2233 4569 3635 3156 3777 2224 2738 3771 3514 M16863 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. 5/15 Gene Ontology BP GO:0043568 0.0527302063041914 0.127248621554242 1785 2919.90909090909 3156 0.00540248712639105 1036 0.900416075626817 0.900416075626817 1 3.0601436378579 1783 4271 4626 3770 1036 1691 1380 3156 4038 4612 1756 3515 M11210 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 12/21 Gene Ontology BP GO:0009148 0.903666398205975 0.955745577874793 2000 3168.36363636364 3157 0.191618877005288 1997 0.220878287935996 -0.254520017070715 -1 0.0164813589149209 1997 4204 3157 4035 3684 2025 2770 2872 4498 3192 2418 3516 M12199 GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. 7/26 Gene Ontology BP GO:0002829 0.177357684613924 0.27914295920761 1300 2479.72727272727 3157 0.0193340314301191 689 0.399139420328026 0.378066110006009 1 0.839609740054825 1296 3157 3867 3626 1883 1133 689 3304 3569 3434 1319 3517 M14929 GO_HEART_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_PROCESS.html A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 63/167 Gene Ontology BP GO:0003015 0.10751616939886 0.193712679285568 4200 2989 3157 0.0102873452182564 854 1.7098823044395 -1.81544570726767 -1 4.62665056169868 4197 2957 926 2845 3878 3196 4629 3157 2178 854 4062 3518 M12342 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that increases the frequency, rate or extent of cardiac muscle contraction. 6/16 Gene Ontology BP GO:0060452 0.0274865694726256 0.0811070991099343 3365 2543.36363636364 3160 0.00278325886055316 500 1.11085831969226 -1.13975148755868 -1 4.60009943230971 3365 3695 3892 1814 1475 3827 3545 546 2158 500 3160 3519 M12360 GO_ENAMEL_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENAMEL_MINERALIZATION.html The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. 4/13 Gene Ontology BP GO:0070166 0.015177197245667 0.0545838317673368 1395 2412.09090909091 3160 0.00152818610004852 407 0.345848460232977 -0.45418522416175 -1 1.65796139410107 1394 3201 3896 3160 4097 813 1934 407 3244 3471 916 3520 M14111 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein. 20/58 Gene Ontology BP GO:0042517 0.420448653844534 0.539713325905494 3790 2867.90909090909 3160 0.0483814444671896 725 0.671837249370926 -0.671837249370926 -1 0.683032947131533 3789 725 1327 1334 3160 3437 3409 3084 2834 3925 4523 3521 M11260 GO_TELOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. 63/120 Gene Ontology BP GO:0032200 0.73314201691186 0.814738722958776 1445 3023 3161 0.113163305633261 1441 0.289522774904057 -0.329190165376597 -1 0.0977890841185165 1441 4123 3161 4445 4162 1809 3010 2114 3516 3203 2269 3522 M11091 GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme adenylate cyclase. 13/45 Gene Ontology BP GO:0007190 0.427920207399677 0.547487881773685 3980 3086.27272727273 3162 0.0495033277973303 1335 0.858982002181133 0.858982002181133 1 0.853043835110221 3978 1795 1335 1790 4100 3631 2350 4438 3070 3162 4300 3523 M10566 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. 17/40 Gene Ontology BP GO:0051154 0.725171723898974 0.808785086251006 3330 3177.54545454545 3163 0.110787450962849 2071 0.40256929488721 0.440883352457862 1 0.140838923137514 3326 2071 2216 3130 3535 4427 3800 2097 3163 3049 4139 3524 M12471 GO_LAGGING_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAGGING_STRAND_ELONGATION.html The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. 6/11 Gene Ontology BP GO:0006273 0.604241793921392 0.707386447094559 2285 2931 3163 0.088528711459674 1475 0.261730086255016 -0.344942884854893 -1 0.149363628992397 2285 3163 3914 3632 4195 1695 1475 2970 3425 3497 1990 3525 M16666 GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 12/39 Gene Ontology BP GO:0035458 0.538011485269382 0.650686982575082 2360 3026.09090909091 3164 0.0677939324278586 1178 0.216180582811441 -0.21857530959372 -1 0.153144160044186 2358 4100 3164 3984 3892 1178 1728 2725 4058 4557 1543 3526 M11099 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. 51/89 Gene Ontology BP GO:0033108 0.139479023096794 0.239626814388005 665 2677.54545454545 3166 0.0135632951579583 459 0.564322045552235 -0.564322045552235 -1 1.32908037673388 663 4361 3460 4356 4316 459 1096 2168 4304 3166 1104 3527 M11299 GO_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT.html The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. 86/210 Gene Ontology BP GO:0017038 0.63389956273523 0.731410454716618 3205 3165.45454545455 3166 0.0873015873015873 1954 1.00744291305309 1.00744291305309 1 0.519459423392241 3205 1954 3308 3148 3166 2942 3338 3528 2983 2863 4385 3528 M11499 GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that activates or increases the frequency, rate or extent of membrane depolarization. 8/17 Gene Ontology BP GO:1904181 0.422063382979137 0.541272294874423 1920 3009.18181818182 3166 0.053353091055077 1649 0.415470702138525 -0.161183689545731 -1 0.420418718102457 1918 3335 3759 3214 4415 3166 2440 1649 3095 3273 2837 3529 M12545 GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. 25/62 Gene Ontology BP GO:1903523 0.298735036746822 0.413174493778819 3170 2965.72727272727 3166 0.0317460317460317 1381 1.13179372635729 1.37263421167935 1 1.64912935404426 3166 2018 1430 2496 3798 3843 4332 4158 2064 1381 3937 3530 M11709 GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glutathione derivative. 13/28 Gene Ontology BP GO:1901687 0.355991663481857 0.479556776820555 2575 2924 3167 0.0392143697638743 1795 0.290125215213726 -0.248970463154423 -1 0.351480405330162 2573 3182 2818 3570 2110 1795 3167 3291 3636 3321 2701 3531 M14166 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. 10/21 Gene Ontology BP GO:0032717 0.133197435103139 0.230501562125931 4340 3164.72727272727 3167 0.0129108443235038 1466 0.399371573571801 -0.331379273520912 -1 0.966153436829321 4336 2823 2559 2832 1466 3648 3227 3167 2505 3934 4315 3532 M11109 GO_IMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving IMP, inosine monophosphate. 7/14 Gene Ontology BP GO:0046040 0.553081480032308 0.664241415362133 1685 2963.45454545455 3168 0.0773800628000297 1362 0.321530990488811 -0.321530990488811 -1 0.216847325616043 1685 4309 3692 4202 3705 1362 2091 2325 4481 3168 1578 3533 M12449 GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione derivative. 13/28 Gene Ontology BP GO:1901685 0.355991663481857 0.479556776820555 2575 2940 3168 0.0392143697638743 1796 0.290125215213726 -0.248970463154423 -1 0.351480405330162 2574 3183 2819 3571 2111 1796 3168 3289 3637 3490 2702 3534 M13328 GO_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_NUCLEAR_DIVISION.html A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. 222/475 Gene Ontology BP GO:0007067 0.852045816216213 0.916388400438239 2570 3360.27272727273 3168 0.159462637775908 1844 1.14518571914155 -0.808913397424817 -1 0.164837589635335 2570 4435 2949 4364 3862 1844 3812 3168 4275 2895 2789 3535 M13428 GO_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRAND_BREAK_REPAIR.html The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. 93/195 Gene Ontology BP GO:0006302 0.764753952981677 0.844412034172159 1565 3138.45454545455 3168 0.123270405273943 1565 0.26652681309136 -0.294214646594579 -1 0.0743042810569864 1565 4536 3168 4465 4005 1619 2718 2294 4245 3738 2170 3536 M13071 GO_RESPONSE_TO_SALT_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. 16/30 Gene Ontology BP GO:0009651 0.769534836727261 0.848278786069485 3170 3045.81818181818 3169 0.124905355245563 1663 0.367264938922389 -0.361451579518036 -1 0.0996226713487428 3169 3986 1701 3658 4623 1663 2254 2352 3966 3644 2488 3537 M11889 GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. 257/638 Gene Ontology BP GO:0060627 0.0949742077320722 0.175125197180306 3440 2937.36363636364 3170 0.00903095878624857 897 1.22243035354782 1.33093539057582 1 3.5109704539102 3438 3797 897 3683 3017 2864 3913 3170 1618 1654 4260 3538 M10978 GO_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 52/130 Gene Ontology BP GO:0009408 0.23527562290095 0.345800796812002 3875 2777.18181818182 3172 0.0240905138747984 666 1.05077947290469 1.05077947290469 1 1.83943156884643 3873 3774 1434 3804 2078 666 3185 3760 3172 2759 2044 3539 M11983 GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. 23/44 Gene Ontology BP GO:0006778 0.155539593543954 0.258740097879113 3000 2962.45454545455 3172 0.0152513589001771 1560 0.321983761258132 -0.241516323442539 -1 0.717596156228894 3000 1966 3172 2122 1560 3409 3969 3770 2311 3386 3922 3540 M15432 GO_NEUTROPHIL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a neutrophil. 13/36 Gene Ontology BP GO:0002446 0.00328861134462727 0.0187013592392192 3175 2908.09090909091 3172 0.000299412504548489 190 0.400137429859411 -0.260888538332545 -1 2.62477464101153 3172 2176 2722 2523 190 3552 4048 3470 2202 4268 3666 3541 M11307 GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 16/29 Gene Ontology BP GO:0071480 0.74541885209966 0.826601320826062 3600 3079.54545454545 3173 0.116952218725855 1894 0.290617029054547 -0.278855636206418 -1 0.0912334935594526 3596 3430 3047 3173 2820 2181 1894 4253 3503 3218 2760 3542 M11129 GO_REGULATION_OF_NOREPINEPHRINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOREPINEPHRINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. 6/23 Gene Ontology BP GO:0014061 0.600160546794344 0.703317874499278 3175 2873.63636363636 3174 0.0875930925319774 1400 0.262683766202592 0.314945258126334 1 0.152405698492828 1400 4184 3697 4189 3175 1598 1917 2292 4305 3174 1679 3543 M12487 GO_LIPOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOXYGENASE_PATHWAY.html The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. 6/15 Gene Ontology BP GO:0019372 0.418289060582023 0.537808179470363 1875 2992.54545454545 3174 0.0527366750791487 1643 0.288060157244138 0.412440012156411 1 0.29453969815031 1989 4185 3917 4374 3174 1871 1874 1643 4475 3501 1915 3544 M12879 GO_REGULATION_OF_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXCRETION.html Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. 8/33 Gene Ontology BP GO:0044062 0.52340095663996 0.635617084269422 2965 3183.09090909091 3174 0.0714285714285714 1640 0.691087527580091 0.614643279998269 1 0.516267961193027 2962 1809 3974 1640 4535 3174 4553 2262 2741 3592 3772 3545 M13452 GO_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that modulates the amount of sodium excreted in urine over a unit of time. 8/27 Gene Ontology BP GO:0035813 0.52340095663996 0.635617084269422 2965 3206.63636363636 3175 0.0714285714285714 1641 0.691087527580091 0.614643279998269 1 0.516267961193027 2963 1810 4076 1641 4536 3175 4554 2260 2742 3743 3773 3546 M15860 GO_REGULATION_OF_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PERMEABILITY.html Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. 56/113 Gene Ontology BP GO:0090559 0.0569346723066092 0.134940114098819 4495 3011.90909090909 3175 0.00531489138268355 1025 1.39934214282505 -0.554099100968402 -1 4.62040419474881 4492 3455 2686 3560 1025 1968 3459 2964 3175 2779 3568 3547 M15930 GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. 3/22 Gene Ontology BP GO:0042069 0.579857310453667 0.686805482764382 3295 3321.63636363636 3175 0.0830626125599813 1995 0.423033407437734 0.556112068397604 1 0.262006592745068 3291 1995 4481 3175 2594 4390 2889 2549 4033 4382 2759 3548 M11819 GO_REGULATION_OF_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_BINDING.html Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 10/33 Gene Ontology BP GO:0035561 0.000748637525908732 0.00671027805558734 4225 3008.27272727273 3176 6.80811273675753e-05 76 0.385295927988432 0.38646884868323 1 3.17843426284109 4221 1500 2824 3101 76 3176 3872 3948 2697 3348 4328 3549 M13573 GO_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 90/182 Gene Ontology BP GO:0009411 0.3373798045095 0.45775991593735 2850 3111.36363636364 3176 0.0367226836104749 1999 1.21329384803913 1.29222580129503 1 1.56291998114188 2849 4217 2080 3990 2074 3396 4316 2197 3176 1999 3931 3550 M16688 GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. 71/187 Gene Ontology BP GO:0034111 0.0308035861680072 0.0881214113235105 2120 3061.27272727273 3176 0.00284032137642137 715 1.14644981542959 1.14644981542959 1 4.59072429767038 2118 3830 715 4308 3024 3836 2605 3986 3450 2626 3176 3551 M11137 GO_POLYOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 11/24 Gene Ontology BP GO:0046174 0.132563194374437 0.2294895270248 2495 3198.45454545455 3177 0.0128452066414632 557 0.220843840554511 0.221592600308359 1 0.535863917076265 2420 4342 2844 4210 4577 2491 557 3622 4451 3177 2492 3552 M12098 GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 14/26 Gene Ontology BP GO:0002068 0.298735036746822 0.413174493778819 3130 3042.72727272727 3177 0.0317460317460317 1846 1.46584243959724 1.46584243959724 1 2.13586958410092 3130 3635 2428 3552 3177 4188 1846 4117 1961 2017 3419 3553 M14472 GO_NUCLEAR_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_IMPORT.html The directed movement of substances into the nucleus. 72/180 Gene Ontology BP GO:0051170 0.307171048225111 0.423454624973038 3370 3203.45454545455 3177 0.0328107584220014 1769 1.00744291305309 1.00744291305309 1 1.42712267054556 3367 1769 3079 2758 2011 3799 3360 4620 3177 2834 4464 3554 M10731 GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA processing. 21/61 Gene Ontology BP GO:0050685 0.715232941175127 0.800961396746048 3180 3321.63636363636 3179 0.107911051808581 1519 0.194608741287086 -0.203454062994805 -1 0.071202363731577 3395 4556 3134 4301 3178 1519 3414 3179 4469 3083 2310 3555 M14770 GO_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 28/98 Gene Ontology BP GO:0014902 0.0309834024509737 0.0883093539471275 4100 3016.54545454545 3179 0.00285714137168476 716 0.515840994862868 -0.578344274390853 -1 2.06376827233055 4096 1934 716 3111 2779 2741 3179 3463 3369 4094 3700 3556 M12237 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. 37/95 Gene Ontology BP GO:0032024 0.171426875229474 0.272207586077444 2600 2927.18181818182 3180 0.0169501728964223 1612 0.816391131298516 -0.816391131298516 -1 1.75117941777159 2597 2961 1839 3180 1612 3987 3412 2224 3446 3443 3498 3557 M12557 GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. 22/42 Gene Ontology BP GO:2000279 0.696200405720489 0.784767779499934 2730 3393 3180 0.10264875070287 2188 0.299798155389989 -0.278462416277071 -1 0.119782880026039 4394 4224 2188 4336 2730 2730 3080 2519 4421 3521 3180 3558 M11732 GO_ANATOMICAL_STRUCTURE_ARRANGEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_ARRANGEMENT.html The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 14/39 Gene Ontology BP GO:0048532 0.239342157121677 0.350446431887716 4550 3110.09090909091 3181 0.024563434636702 912 1.26823853158809 -1.38975139692581 -1 2.19220195697262 4547 3181 1149 2108 3708 3076 4406 4548 3627 912 2949 3559 M12652 GO_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT.html The directed movement of calcium ions into a cell or organelle. 38/111 Gene Ontology BP GO:0070509 0.161385165508919 0.258740097879113 3730 3050.90909090909 3181 0.0158730158730159 1291 1.29994081892301 1.29994081892301 1 2.89714155618358 3730 3835 1291 3830 2534 2492 3855 3181 1605 2650 4557 3560 M14589 GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that activates or increases the frequency, rate or extent of protein acetylation. 22/48 Gene Ontology BP GO:1901985 0.189401290539688 0.294899460756462 3350 2909.90909090909 3181 0.0189082403962574 1177 0.433014485779489 0.467218924214483 1 0.8716709918158 3350 2742 1818 3181 2188 4477 1683 1177 3287 4049 4057 3561 M14774 GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. 154/403 Gene Ontology BP GO:0002831 0.557443745451391 0.666249592815201 2750 3239.27272727273 3181 0.0714285714285714 2656 1.16585524954904 1.2820135027605 1 0.780475811783332 2746 3373 2933 3934 3181 3658 3368 2656 2791 2701 4291 3562 M13224 GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. 22/63 Gene Ontology BP GO:1903312 0.605798949189004 0.708673348723746 2225 3008.63636363636 3182 0.0811448142749197 1292 0.23106721770282 -0.321642249823703 -1 0.131172654431086 2221 4172 3215 4387 3182 1292 2714 2001 4188 3678 2045 3563 M11532 GO_REGULATION_OF_WATER_LOSS_VIA_SKIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WATER_LOSS_VIA_SKIN.html A process that modulates the rate or extent of water loss from an organism via the skin. 17/34 Gene Ontology BP GO:0033561 0.439006304971165 0.557828755878796 2525 3158 3183 0.0511927420149349 1396 0.287856261912957 0.365305508463493 1 0.276986968394677 2524 4559 1396 4591 3910 2439 2709 1623 4522 3282 3183 3564 M12542 GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of glial cell proliferation. 13/29 Gene Ontology BP GO:0060251 0.232850105696956 0.342669743502683 3965 3187.63636363636 3184 0.0238095238095238 1792 0.297825091472373 -0.294190391453699 -1 0.525820469547584 3964 2893 3184 2809 3930 2196 4223 3432 1792 3516 3125 3565 M16876 GO_CYTOSOLIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_TRANSPORT.html The directed movement of substances or organelles within the cytosol. 125/284 Gene Ontology BP GO:0016482 0.0622337715801386 0.14276255012183 4165 3095 3187 0.00582429848730038 1075 1.13803925721467 -0.956456561975776 -1 3.65190417646835 4165 3522 3187 3329 1075 1494 4433 4594 3179 2849 2218 3566 M14839 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 31/84 Gene Ontology BP GO:0070303 0.0444577159224609 0.112959203501848 3530 2854.81818181818 3188 0.00412567165694752 921 2.35459573801311 2.35459573801311 1 8.46465976834233 3527 3533 2082 2533 921 4398 3329 3188 1162 2562 4168 3567 M10592 GO_MYELOID_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. 28/60 Gene Ontology BP GO:0061515 0.466738071388703 0.580826820010117 3240 3098.72727272727 3189 0.0555555555555556 2243 1.65735694990685 1.65735694990685 1 1.48439475295824 3237 3498 2549 3381 2877 2243 3515 4553 2528 2516 3189 3568 M12099 GO_RESPONSE_TO_MAGNESIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MAGNESIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. 9/45 Gene Ontology BP GO:0032026 0.238589305485243 0.349674919623732 2570 2925 3189 0.0268900857862349 1593 1.11882204112119 1.11882204112119 1 1.93799438968279 2566 3189 3848 2553 1885 3776 3400 2635 3413 1593 3317 3569 M15483 GO_CELL_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_RECOGNITION.html Cell recognition between cells. May involve the formation of specialized cell junctions. 42/135 Gene Ontology BP GO:0009988 0.0839184282471183 0.158445571591463 3395 2866.63636363636 3189 0.00793650793650794 1156 1.31394404283802 1.31394404283802 1 3.99060893201362 3393 3802 1163 3754 2526 3438 3189 2132 1156 2685 4295 3570 M16039 GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 12/31 Gene Ontology BP GO:1902176 0.911768430006838 0.962148529715562 3695 3345 3190 0.198049362405513 2461 0.287717852617722 -0.266308797318701 -1 0.0183017702612129 3695 2505 3086 2763 3190 2461 3608 4326 3700 4405 3056 3571 M10086 GO_MEIOTIC_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. 29/69 Gene Ontology BP GO:0045132 0.688558401829192 0.77872965563723 2500 3146.54545454545 3191 0.10061978601324 1443 0.279296333069758 -0.276918106075132 -1 0.11514773985016 2498 4169 2453 3852 3191 1443 3216 3493 4473 2951 2873 3572 M11686 GO_REGULATION_OF_PROTEIN_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_GLYCOSYLATION.html Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. 5/16 Gene Ontology BP GO:0060049 0.429405248111751 0.548770837951972 2245 3003.90909090909 3191 0.05456260221879 1661 0.301515889782707 0.474611712307341 1 0.298268097324699 2243 3871 3790 3731 4546 2316 1696 1661 3191 3313 2685 3573 M14646 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that stops, prevents, or reduces the rate of leukocyte degranulation. 7/18 Gene Ontology BP GO:0043301 0.0557405405087524 0.132515785756343 2405 3052.72727272727 3192 0.00571901376581593 393 0.369358251470378 0.384969511116184 1 1.23060070220689 2405 3192 4265 3529 3929 2743 393 2961 4181 4064 1918 3574 M13638 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS.html The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. 20/43 Gene Ontology BP GO:0002200 0.666980363229991 0.758975695142582 2330 3203.81818181818 3194 0.0951258794890333 2245 0.847293883868049 0.847293883868049 1 0.385209581014752 2330 4133 3194 3575 2676 2245 3523 4080 3057 3795 2634 3575 M16502 GO_CELLULAR_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 45/137 Gene Ontology BP GO:0035690 0.273807347995373 0.392251625036259 3470 3113 3194 0.0286665385058772 1726 1.4365122782753 -1.42279293755586 -1 2.21619483801539 3466 3345 1726 3194 1915 4283 4396 2162 3050 2184 4522 3576 M11482 GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. 42/77 Gene Ontology BP GO:0072384 0.0180072746038733 0.0616870981209885 1995 2534.18181818182 3195 0.00165057980162238 173 0.802844411190204 -0.802844411190204 -1 3.68683949582559 1993 4283 3195 4154 4039 173 1797 1486 3261 3266 229 3577 M11015 GO_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_PROCESSING.html Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. 235/527 Gene Ontology BP GO:0006397 0.52612418074186 0.637971943375412 1715 3093.63636363636 3196 0.0656384489456835 1157 1.10537615948907 1.37458848288313 1 0.819018332699366 1713 4487 3505 4420 3897 1157 3196 3055 3710 2919 1971 3578 M13184 GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 9/16 Gene Ontology BP GO:0010870 0.620378405381674 0.721547328704187 3830 3201.72727272727 3196 0.0923151413575587 2315 0.420161461238236 0.352342199298235 1 0.226048221968381 3830 3219 4030 3011 2654 2638 2315 4243 3196 3667 2416 3579 M15310 GO_ENDOPLASMIC_RETICULUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. 21/47 Gene Ontology BP GO:0007029 0.277044207729318 0.394448909366395 3320 2757.18181818182 3196 0.0290609315113549 747 0.796538314240086 -0.796538314240086 -1 1.22153298846509 3319 3598 3196 3879 2272 747 2058 1961 3727 4234 1338 3580 M14554 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. 93/194 Gene Ontology BP GO:1901988 0.232850105696956 0.342669743502683 3470 2965.27272727273 3197 0.0238095238095238 1015 1.30931078930951 1.42798520168239 1 2.31163335095048 3467 3619 2592 2672 1965 3197 4042 3741 1853 1015 4455 3581 M11697 GO_ORGAN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. 11/46 Gene Ontology BP GO:0048799 0.161385165508919 0.258740097879113 4030 2963.72727272727 3198 0.0158730158730159 1288 0.548816120392337 0.520107280141037 1 1.22313105782499 4029 1288 1725 1879 2401 4258 4317 3198 1608 3316 4582 3582 M13544 GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. 21/62 Gene Ontology BP GO:0000381 0.247652831861961 0.360694342320622 1985 2939.18181818182 3198 0.0255371225538397 800 0.237204956831476 -0.259635787214026 -1 0.3987476196923 1982 4171 3198 4375 2984 800 2629 3362 4141 3771 918 3583 M11254 GO_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. 72/165 Gene Ontology BP GO:0051340 0.0659783460950207 0.148635352216973 365 2278.09090909091 3201 0.00618584809838465 281 0.649810243057386 -0.649810243057386 -1 2.04202034444066 361 3206 3428 3443 3658 281 1226 1618 3814 3201 823 3584 M13747 GO_MRNA_CLEAVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE.html Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. 13/22 Gene Ontology BP GO:0006379 0.150218824966642 0.252248102828253 3180 3228.09090909091 3201 0.0146889047060318 1539 0.955023857704091 0.955023857704091 1 2.1684409419765 3180 2892 3140 3514 1539 4019 3201 3814 2522 3826 3862 3585 M16440 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. 39/112 Gene Ontology BP GO:1901019 0.726270090971166 0.809038395484434 3690 3245.63636363636 3201 0.111111111111111 2043 1.14413454014118 1.34463734700163 1 0.399684992312075 3689 3710 2396 2856 3220 3201 3640 3164 3170 2043 4613 3586 M16590 GO_AZOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AZOLE_TRANSPORT.html The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/15 Gene Ontology BP GO:0045117 0.147859119791321 0.249186894080256 4100 3161.36363636364 3201 0.0158730158730159 1349 0.546006499826352 -0.612344815897187 -1 1.25073178097397 4099 1349 4587 2906 4234 3720 1855 2852 1434 4538 3201 3587 M13269 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 12/18 Gene Ontology BP GO:0010801 0.602996494633072 0.706106614017996 3690 3153.90909090909 3202 0.0805528767828872 1893 0.266835267390915 -0.214811051879533 -1 0.153073615159925 2459 3991 3015 3554 3202 3686 2671 1893 3333 3690 3199 3588 M10884 GO_SNORNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. 5/12 Gene Ontology BP GO:0016074 0.981564635662851 0.999999998379914 3005 3462.63636363636 3203 0.329243063563223 2640 0.181678104145239 -0.17792883091105 -1 3.08276764099038e-10 3005 4051 3652 4184 4122 2640 2906 3187 4028 3111 3203 3589 M12655 GO_BEHAVIORAL_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_PAIN.html Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 10/32 Gene Ontology BP GO:0048266 0.687555590231963 0.777855898013402 2665 3407.36363636364 3205 0.100356905388569 2027 0.232154680281946 0.248050892337737 1 0.0961419246084178 2663 4305 2922 4350 2898 3909 3205 2027 4535 3547 3120 3590 M13992 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 13/23 Gene Ontology BP GO:0009147 0.689628293630242 0.779251440088882 1570 2936 3205 0.100901101076539 1448 0.226149363489084 -0.257691130984845 -1 0.0929866965884296 1568 3989 3205 3968 3426 1448 1754 2645 4430 3899 1964 3591 M16511 GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. 448/916 Gene Ontology BP GO:0006974 0.598454156430621 0.702350515374411 2180 3105.54545454545 3206 0.0796014594468004 1282 1.08920603166358 -0.804530267464407 -1 0.634414510995862 2180 4484 3458 4525 3261 1282 3184 3206 3553 2928 2100 3592 M11662 GO_TRANSLATIONAL_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_TERMINATION.html The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). 62/100 Gene Ontology BP GO:0006415 0.698669520012152 0.785833958676459 1225 3040.81818181818 3207 0.10331422848666 1223 0.751302067173766 0.751302067173766 1 0.29849753661309 1223 3907 3500 3864 2899 2042 3207 3038 3589 3309 2871 3593 M12335 GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 16/35 Gene Ontology BP GO:0009225 0.0332220027293952 0.092809722426343 4335 2944.72727272727 3207 0.00306677768402902 776 0.715858725339802 0.715858725339802 1 2.80533864921962 4333 1904 3207 1741 776 3672 3134 4372 2208 3466 3579 3594 M13624 GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 10/24 Gene Ontology BP GO:0051043 0.0353393690835838 0.0961785994461194 3805 3187.90909090909 3207 0.00326546738992005 585 0.408509914300858 -0.244968143785642 -1 1.57687505660423 3802 3108 1915 2851 4114 3207 4505 585 2822 3792 4366 3595 M12902 GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 9/15 Gene Ontology BP GO:1902895 0.167118232905013 0.26645946269848 1665 3073.27272727273 3210 0.018120177354665 1664 0.289048674947811 0.104616265405196 1 0.630186498020383 3498 4023 3977 3752 1664 1665 3129 3177 3210 3599 2112 3596 M10274 GO_NUCLEAR_ENVELOPE_REASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_REASSEMBLY.html The reformation of the nuclear envelope following its breakdown in the context of a normal process. 17/24 Gene Ontology BP GO:0031468 0.982992683943975 0.999999998379914 3785 3473.90909090909 3212 0.30952380952381 2711 0.283883115848691 0.264910129605691 1 5.81238568966269e-10 3782 2711 3022 3212 4144 3755 3093 3001 3935 2992 4566 3597 M16513 GO_POLYOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 14/43 Gene Ontology BP GO:0046173 0.171139043723848 0.272029640537428 3645 3058.81818181818 3212 0.016919132892529 1608 1.23889395501682 -1.23889395501682 -1 2.65879408631177 3643 3918 2257 3461 1608 2790 4242 3212 3770 2037 2709 3598 M12642 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. 69/180 Gene Ontology BP GO:1903169 0.336697938780801 0.457235603907358 4230 3079.18181818182 3213 0.0366326116141876 2066 1.14413454014118 1.34463734700163 1 1.4759931056869 4230 3526 2066 2680 2073 2237 4435 3316 3213 2603 3492 3599 M12894 GO_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXIT_FROM_MITOSIS.html The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. 10/16 Gene Ontology BP GO:0010458 0.0271720939356462 0.0805416636788611 975 2621.81818181818 3214 0.00250123775615485 256 0.226101209473453 0.258385990129472 1 0.938899833770662 973 4104 3025 3747 4448 574 256 3214 4361 3596 542 3600 M10070 GO_APICAL_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, apical regions of the cell. 11/30 Gene Ontology BP GO:0045176 0.717550288427649 0.802824365478077 4415 3253 3217 0.108573464507778 1522 0.267986067879411 -0.258206966385933 -1 0.0970229073771344 4412 3106 2811 3217 4033 1522 3497 2621 4369 2947 3248 3601 M16358 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE.html Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. 13/40 Gene Ontology BP GO:0043576 0.466738071388703 0.580826820010117 4590 3368.45454545455 3218 0.0555555555555556 1965 1.38933387508025 1.38933387508025 1 1.24434263502787 4587 3215 2374 3218 4599 3270 2706 4583 2512 1965 4024 3602 M14912 GO_TETRAHYDROFOLATE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_INTERCONVERSION.html The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. 6/13 Gene Ontology BP GO:0035999 0.833323203195213 0.903233457752032 2200 3222.45454545455 3220 0.164036117034154 1876 0.334922527337931 -0.465860317254251 -1 0.0561918974503207 2196 2985 4315 3220 3737 1876 2604 4394 3560 4128 2432 3603 M14506 GO_AMMONIUM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSPORT.html The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 27/97 Gene Ontology BP GO:0015696 0.63389956273523 0.731410454716618 3295 3364.36363636364 3221 0.0873015873015873 1867 1.03855172572717 1.03855172572717 1 0.535499802147427 3293 2843 1867 3046 3221 4094 4635 4626 2981 2498 3904 3604 M11841 GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 6/17 Gene Ontology BP GO:0060218 0.804786930807859 0.878564003175915 2570 3232 3223 0.150720015425668 2125 0.500776565503907 0.536621264082542 1 0.106879154600038 2567 3223 3815 3216 3852 3051 2523 4230 3597 3353 2125 3605 M15030 GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. 17/44 Gene Ontology BP GO:0031062 0.0309424278045619 0.0882629189081616 3225 2837.09090909091 3223 0.00285330835817753 457 0.9282856402567 -0.9282856402567 -1 3.71467498092135 3223 4068 2794 3614 746 1167 4351 3004 3624 4160 457 3606 M10159 GO_NEURONAL_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_DIVISION.html The self-renewing division of a neuronal stem cell. 6/21 Gene Ontology BP GO:0036445 0.00355091771662334 0.0196741180886422 3550 2765.27272727273 3224 0.00035566045675194 219 1.65735694990685 1.65735694990685 1 10.7331937948847 3549 3224 3545 2043 219 3861 3648 3835 2139 1302 3053 3607 M11322 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_ELONGATION.html Any process that modulates the frequency, rate, extent or accuracy of translational elongation. 16/25 Gene Ontology BP GO:0006448 0.890510732106303 0.9463070325665 2210 3234.81818181818 3224 0.182156622965493 2081 0.173087310353943 -0.184766009630332 -1 0.0157471885167038 2209 3844 3441 4022 3132 2081 3949 3217 3765 3224 2699 3608 M16687 GO_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a cell of a different type via adhesion molecules. 15/46 Gene Ontology BP GO:0034113 0.588396880110587 0.694969909527717 2425 3078.36363636364 3224 0.0775292479357913 1269 0.234089079844625 -0.332294379861661 -1 0.140423215846094 2425 3754 3100 3794 3224 1269 2275 3254 4342 4565 1860 3609 M11331 GO_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEPARATION.html The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). 14/21 Gene Ontology BP GO:0051304 0.907429966483926 0.959070642928493 2125 3165.63636363636 3225 0.194542248232917 2039 0.270182886354415 -0.268232861073253 -1 0.0186134722663725 2123 3988 2268 3954 3599 2039 3259 2957 4549 3225 2861 3610 M14924 GO_NEUROBLAST_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_DIVISION.html The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. 6/21 Gene Ontology BP GO:0055057 0.00355091771662334 0.0196741180886422 3550 2839.54545454545 3225 0.00035566045675194 220 1.65735694990685 1.65735694990685 1 10.7331937948847 3550 3225 4319 2044 220 3862 3649 3839 2140 1333 3054 3611 M12196 GO_BASE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASE_EXCISION_REPAIR.html In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. 24/43 Gene Ontology BP GO:0006284 0.339485520036606 0.46034791750291 705 2629.54545454545 3226 0.0370013738940997 701 0.55936453995665 -0.55936453995665 -1 0.715353958336189 701 3656 3226 3783 3327 986 1921 2270 4213 3433 1409 3612 M12388 GO_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MEMBRANE.html The process of directing proteins towards a membrane, usually using signals contained within the protein. 100/285 Gene Ontology BP GO:0006612 0.622500527910991 0.723652967223518 1890 3180.90909090909 3226 0.0847539781615936 1449 1.57385905777205 1.57385905777205 1 0.839180875163114 1889 4599 3495 4569 3193 3242 1449 3563 3226 2784 2981 3613 M14409 GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of a different species. 430/1069 Gene Ontology BP GO:0044419 0.295608729906684 0.413174493778819 3230 3239.63636363636 3227 0.0313544092750614 1973 1.24420930534577 1.44268210930527 1 1.81292937065891 3227 4186 3411 3620 1973 2424 2764 4168 2857 2806 4200 3614 M16124 GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. 430/1069 Gene Ontology BP GO:0044403 0.295608729906684 0.413174493778819 3230 3239.36363636364 3228 0.0313544092750614 1974 1.24420930534577 1.44268210930527 1 1.81292937065891 3228 4187 3412 3621 1974 2425 2765 4155 2858 2807 4201 3615 M11739 GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT.html The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. 8/21 Gene Ontology BP GO:0060712 0.214139132665174 0.322775948981753 3230 2811.81818181818 3229 0.0238095238095238 684 0.640805162824474 0.582418919505381 1 1.19454395681131 3229 1051 3798 684 3746 3494 2987 2980 1646 3331 3984 3616 M12317 GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. 67/140 Gene Ontology BP GO:0007006 0.0814144581717904 0.158445571591463 3230 3206.81818181818 3229 0.00769029957854328 1208 1.39934214282505 -0.554099100968402 -1 4.24997341747848 4503 3938 3106 3868 1208 2168 3818 3386 3229 2822 3229 3617 M13081 GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). 20/42 Gene Ontology BP GO:0072350 0.526091304070032 0.637971943375412 3230 3105.81818181818 3230 0.0656325560076172 1528 0.287328525418339 -0.261354694860587 -1 0.212893436917553 3308 3283 3230 3823 2428 1528 3229 2767 4009 3646 2913 3618 M11293 GO_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 305/702 Gene Ontology BP GO:0030163 0.00726833362293661 0.0324177454479296 3165 2902.45454545455 3231 0.000662950755858445 72 1.22118288435262 1.42500697484929 1 6.90312887133154 3161 3932 3277 4126 4135 72 3231 3376 3180 2868 569 3619 M11533 GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. 9/36 Gene Ontology BP GO:1903306 0.152194766529025 0.254828813917873 1615 2580.72727272727 3231 0.0163748845038177 633 0.40256502468307 0.488125481874172 1 0.90729384976164 1611 3257 3763 3465 3231 1852 633 2031 3337 3283 1925 3620 M10192 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT.html The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/32 Gene Ontology BP GO:0043252 0.383533189000237 0.505032500433381 2840 2983.09090909091 3232 0.0472236465796287 1064 1.25240526293404 1.25240526293404 1 1.41039698256238 2839 3306 3552 2724 3735 2991 1064 4300 3767 1304 3232 3621 M12673 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that modulates the frequency, rate or extent of protein localization to the cell surface. 21/46 Gene Ontology BP GO:2000008 0.0839184282471183 0.158445571591463 3235 2992.36363636364 3232 0.00793650793650794 853 0.998090216195874 -0.781628281319039 -1 3.031322188613 3232 2067 2140 2225 4531 3374 4299 3544 853 2324 4327 3622 M12586 GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 4/20 Gene Ontology BP GO:0022010 0.0796795249440755 0.158445571591463 2015 2757.72727272727 3233 0.00826895526226987 461 0.330385920775444 0.330385920775444 1 1.0034224923584 2012 3489 3935 3233 3976 2336 461 1382 4088 3529 1894 3623 M11777 GO_SYNAPTIC_VESICLE_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_RECYCLING.html The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. 15/39 Gene Ontology BP GO:0036465 0.514011397665828 0.627050688219243 4345 3199.54545454545 3234 0.0634920634920635 2264 0.370946854751855 0.320345279562875 1 0.285408561890361 4342 2264 2855 3359 3234 2708 3425 3906 2704 3340 3058 3624 M12986 GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM.html The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 4/20 Gene Ontology BP GO:0032291 0.0796795249440755 0.158445571591463 2015 2769.63636363636 3234 0.00826895526226987 462 0.330385920775444 0.330385920775444 1 1.0034224923584 2013 3490 3990 3234 3977 2337 462 1359 4089 3620 1895 3625 M11360 GO_PROTEIN_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEALKYLATION.html The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 15/32 Gene Ontology BP GO:0008214 0.506118604659064 0.622162743296806 2450 2850.36363636364 3236 0.0621194809086734 1245 0.285691787074284 -0.312402126311383 -1 0.223498466400609 2449 3390 3243 3937 3480 1245 2489 3017 3436 3236 1432 3626 M15862 GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 9/16 Gene Ontology BP GO:0032785 0.496663926928525 0.613300694874772 2955 3301.45454545455 3236 0.0663463364900032 1758 0.22348225536253 -0.316905071662823 -1 0.180116942252516 2953 3861 4469 3785 2432 1943 3236 3150 4363 4366 1758 3627 M10842 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. 35/89 Gene Ontology BP GO:0002720 0.234269496173212 0.344540155442579 3675 2848.18181818182 3237 0.0239738584274594 1251 1.76654498878037 1.76654498878037 1 3.10304369272479 3675 3237 1251 3242 1946 4238 3827 1268 2264 1897 4485 3628 M11907 GO_HISTONE_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEUBIQUITINATION.html The modification of histones by removal of ubiquitin groups. 10/27 Gene Ontology BP GO:0016578 0.0591271769397558 0.137937037524265 2710 2749.63636363636 3237 0.00552534241215542 458 0.237548940077375 -0.260643854175949 -1 0.775746626407453 2708 3788 3237 3727 4610 647 1309 2246 4149 3367 458 3629 M13267 GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. 7/21 Gene Ontology BP GO:0033605 0.155318603225368 0.258740097879113 3225 3208 3237 0.0167379149238059 1604 0.650112755713168 -0.650112755713168 -1 1.44888802109245 3224 3553 4041 2995 1604 3237 3566 2151 3190 3689 4038 3630 M15868 GO_DNA_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. 13/17 Gene Ontology BP GO:0006266 0.987177156371992 0.999999998379914 3155 3494.27272727273 3237 0.327025548890433 2729 0.287957404748796 -0.310774602013194 -1 5.92119887144187e-10 3154 3756 2729 3643 4263 2915 3233 3237 4196 4367 2944 3631 M11368 GO_POSTREPLICATION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTREPLICATION_REPAIR.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. 26/72 Gene Ontology BP GO:0006301 0.767905466455287 0.84708602536277 2690 3123.54545454545 3238 0.124344713783424 2076 0.73369093094103 -0.759980613502947 -1 0.200719638093861 2687 4256 3115 3544 3374 2076 3591 2192 4074 3238 2212 3632 M10835 GO_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_LOCALIZATION.html Any process in which is the spindle is transported to, and/or maintained in, a specific location. 26/67 Gene Ontology BP GO:0051653 0.205468523871093 0.31370942332571 3340 3206.63636363636 3240 0.0206922497400945 1736 0.889829409089437 -0.889829409089437 -1 1.70055109273392 3336 3240 2621 3649 1736 2665 4426 3641 3943 3098 2918 3633 M15584 GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. 10/16 Gene Ontology BP GO:0070234 0.061621408884188 0.141877400573996 2885 2746.36363636364 3241 0.0057652979828634 817 1.46584243959724 1.46584243959724 1 4.71883524429229 2884 2793 817 3241 3286 3272 1570 3474 3547 1713 3613 3634 M13741 GO_PROTEIN_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMETHYLATION.html The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 15/32 Gene Ontology BP GO:0006482 0.506118604659064 0.622162743296806 2450 2903.72727272727 3244 0.0621194809086734 1246 0.285691787074284 -0.312402126311383 -1 0.223498466400609 2450 3391 3244 3938 3481 1246 2490 3009 3437 3822 1433 3635 M16764 GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that modulates the frequency, rate or extent of response to reactive oxygen species. 19/43 Gene Ontology BP GO:1901031 0.544300355908671 0.656068916285646 3200 3108.90909090909 3244 0.0689547474736239 1803 0.377287626230083 0.47057236788206 1 0.262150567765117 3200 2350 2260 3244 3664 4050 1889 1803 3257 4586 3895 3636 M10707 GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 9. 20/53 Gene Ontology BP GO:0034162 0.466738071388703 0.580826820010117 3745 3143.18181818182 3245 0.0555555555555556 1953 1.29644110978073 1.29644110978073 1 1.16114418256259 3741 3245 3174 3301 3987 1953 3616 3718 2548 2280 3012 3637 M13320 GO_RENAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_WATER_HOMEOSTASIS.html Renal process involved in the maintenance of an internal steady state of water in the body. 19/53 Gene Ontology BP GO:0003091 0.844914163947124 0.911886672061017 3245 3250.27272727273 3245 0.155857728442459 1811 0.792904243146179 -0.792904243146179 -1 0.120567291564765 3245 3810 1811 4314 3122 2340 2470 3914 4557 3708 2462 3638 M11426 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. 40/88 Gene Ontology BP GO:1903363 0.13545691827792 0.233714779473943 1350 2442.18181818182 3248 0.0131450339998051 451 0.674350887224881 -0.674350887224881 -1 1.61598923340889 1349 4008 3322 3344 4492 451 766 1145 3902 3248 837 3639 M12068 GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. 6/17 Gene Ontology BP GO:0032460 0.52340095663996 0.635617084269422 2760 3128.72727272727 3249 0.0714285714285714 2340 0.461063978111531 0.504182605378683 1 0.344431856196249 2760 2765 3846 2407 3595 3942 3249 2340 2722 3406 3384 3640 M12690 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. 31/84 Gene Ontology BP GO:0032873 0.0444577159224609 0.112959203501848 3530 2859.09090909091 3249 0.00412567165694752 920 2.35459573801311 2.35459573801311 1 8.46465976834233 3526 3532 2081 2532 920 4397 3328 3249 1161 2557 4167 3641 M16390 GO_EPITHELIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. 7/23 Gene Ontology BP GO:0072148 0.878147610886371 0.937274247587117 2600 3141.36363636364 3249 0.189816480107517 1745 0.555989498706856 0.695136226977739 1 0.0593737848069223 2600 1745 4557 2058 3249 3435 2146 2916 4005 4487 3357 3642 M10563 GO_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that modulates the frequency, rate or extent of cellular senescence. 25/46 Gene Ontology BP GO:2000772 0.11434146634871 0.203639212986982 4150 2914.18181818182 3250 0.010977826722928 1381 1.38975139692581 -1.38975139692581 -1 3.64593979564467 4146 3680 1703 3250 1381 3421 4526 2274 3798 2437 1440 3643 M14531 GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. 8/25 Gene Ontology BP GO:0035590 0.286010180099371 0.404737965925444 1960 3073.36363636364 3250 0.0331275136820692 894 0.960186285948682 0.960186285948682 1 1.43173623246465 1960 4209 4248 3894 2912 2516 894 3250 3645 4039 2240 3644 M12386 GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION.html Any process that activates or increases the frequency, rate or extent of vasoconstriction. 16/45 Gene Ontology BP GO:0045907 0.38728555749989 0.507956735444064 1890 3028.45454545455 3251 0.0435553794435605 1887 0.341153257844672 0.452968284320296 1 0.380942977227622 1887 2851 2589 3251 2176 3794 3911 1913 4093 3475 3373 3645 M14719 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. 6/27 Gene Ontology BP GO:2000136 0.33296556889208 0.452829272514917 3255 3135.54545454545 3251 0.0396825396825397 1763 0.323438486403862 -0.229881857191724 -1 0.422415710894274 3251 3450 4281 2712 2616 2909 1763 3657 2165 4083 3604 3646 M15477 GO_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of organelle assembly. 91/202 Gene Ontology BP GO:1902115 0.19904360863395 0.306460529469592 3065 3139.45454545455 3252 0.0199749647465275 599 0.775061391134289 -0.755777475721829 -1 1.51108839881281 3063 4316 3252 4096 4266 599 2862 2591 3513 4288 1688 3647 M13497 GO_PROTEIN_ADP_RIBOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ADP_RIBOSYLATION.html The transfer, from NAD, of ADP-ribose to protein amino acids. 12/22 Gene Ontology BP GO:0006471 0.147593526290723 0.249186894080256 4145 3201 3254 0.014412565053864 1527 0.335203960565292 0.30805084467674 1 0.767848453605206 4143 2311 2918 2842 1527 3534 2255 4599 3254 3755 4073 3648 M13928 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 10/28 Gene Ontology BP GO:0010592 0.597318307603006 0.701403364238937 3585 3159.54545454545 3255 0.0793650793650794 1700 1.14672566625037 1.14672566625037 1 0.6704681572873 3582 3298 2710 2284 3853 4585 3255 2947 2812 1700 3729 3649 M15372 GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle phase transition. 209/442 Gene Ontology BP GO:1901987 0.667434366415499 0.758975695142582 4415 3343.45454545455 3255 0.0952380952380952 1575 1.22982171263372 1.31481901864389 1 0.559120177466004 4414 3732 3107 3255 4124 1575 4234 3678 3053 2457 3149 3650 M15760 GO_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 360/808 Gene Ontology BP GO:0010564 0.466738071388703 0.580826820010117 4265 3234.27272727273 3256 0.0555555555555556 1319 1.32223470698417 1.42664811929488 1 1.1842459533401 4261 4003 2724 3256 3730 1319 4325 4466 2587 1986 2920 3651 M11003 GO_POLYOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 47/118 Gene Ontology BP GO:0019751 0.500374224651197 0.616897908936673 2635 3164.36363636364 3257 0.0611329967360095 1224 1.23889395501682 -1.23889395501682 -1 0.986550498064067 2632 4392 2642 4371 2665 3257 1224 3944 3555 2727 3399 3652 M11612 GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 23/61 Gene Ontology BP GO:0010591 0.161385165508919 0.258740097879113 3260 2737.27272727273 3258 0.0158730158730159 1192 1.2303348545442 1.2303348545442 1 2.74201270028729 3258 1592 2158 1192 4384 4275 3287 3572 1467 1294 3631 3653 M12267 GO_ECTODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. 15/39 Gene Ontology BP GO:0007398 0.514011397665828 0.627050688219243 3195 3321.81818181818 3258 0.0634920634920635 1759 1.38975139692581 -1.38975139692581 -1 1.06928241250978 3191 4561 2418 4252 4081 3258 4375 3939 2637 2069 1759 3654 M14403 GO_POTASSIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_IMPORT.html The directed movement of potassium ions into a cell or organelle. 12/35 Gene Ontology BP GO:0010107 0.35943518917414 0.479556776820555 4105 3109.27272727273 3259 0.0396825396825397 1181 1.38933387508025 1.38933387508025 1 1.68314785526963 4104 1181 2700 2478 3259 3719 3975 4180 2177 1880 4549 3655 M14396 GO_MRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION.html The cellular synthesis of messenger RNA (mRNA) from a DNA template. 12/33 Gene Ontology BP GO:0009299 0.555979672359033 0.666249592815201 2940 3130.27272727273 3260 0.0711497252318425 1788 0.377387406011675 0.437945318633395 1 0.252640061481209 2940 4205 1788 3861 2513 3519 2834 1819 3693 4001 3260 3656 M14706 GO_RRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an rRNA molecule. 7/14 Gene Ontology BP GO:0031125 0.52340095663996 0.635617084269422 3500 3319.63636363636 3260 0.0714285714285714 2364 0.292560828032206 -0.242552594347701 -1 0.218553766512756 3496 2364 4276 3260 3767 2606 2658 4111 2762 4078 3138 3657 M12830 GO_LYMPHANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHANGIOGENESIS.html Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. 4/15 Gene Ontology BP GO:0001946 0.16477694887958 0.263087817623071 3395 2951.36363636364 3261 0.017844513173697 1403 0.238595476050025 -0.223854277652427 -1 0.525196703574019 3392 2327 3966 2971 1652 2520 1403 3261 4018 3583 3372 3658 M13159 GO_CARNITINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARNITINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. 6/16 Gene Ontology BP GO:0009437 0.112087051312046 0.200238622255417 1265 2614.81818181818 3261 0.0118177722068099 636 0.353709685299923 0.436857528387213 1 0.937758139425073 1262 3261 4025 3668 3822 1137 937 2400 3951 3664 636 3659 M16755 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 28/72 Gene Ontology BP GO:0032784 0.277518445372868 0.394766587581564 2260 3188.36363636364 3261 0.0291188494506504 986 0.89163686584869 -0.89163686584869 -1 1.36618825226602 2260 4547 3261 4386 4059 1022 2694 2855 4419 4583 986 3660 M12022 GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS.html The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. 6/15 Gene Ontology BP GO:0048703 0.159948720368951 0.258740097879113 2775 3058.54545454545 3262 0.0172782236859508 1629 0.341165564368619 0.390414033343137 1 0.760346101540525 2772 3262 3842 3485 1629 3577 2432 2445 4010 3395 2795 3661 M10123 GO_SINGLE_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_FERTILIZATION.html The union of male and female gametes to form a zygote. 40/166 Gene Ontology BP GO:0007338 0.298735036746822 0.413174493778819 4335 2914.27272727273 3263 0.0317460317460317 1321 1.44867085052382 -0.834112344367993 -1 2.11084897218187 4334 3834 1610 3263 4047 1321 3669 1779 2104 2667 3429 3662 M13299 GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. 10/26 Gene Ontology BP GO:0006688 0.493701792750794 0.610780022313333 4540 3122.54545454545 3263 0.06 738 0.539901192426161 -0.394335841929919 -1 0.438802374242902 4538 738 1638 1893 3263 3246 3666 4393 2918 3702 4353 3663 M11478 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. 21/48 Gene Ontology BP GO:1902883 0.9025511425933 0.955001129229876 3305 3337.36363636364 3264 0.190772535833385 2514 0.315878274675708 -0.250590431133613 -1 0.0239757724683616 3304 2668 2848 3198 4072 4531 2618 2514 3756 3264 3938 3664 M13356 GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. 15/46 Gene Ontology BP GO:0086019 0.891073518496821 0.9463070325665 2225 3068 3264 0.182539682539683 2071 1.13975148755868 -1.13975148755868 -1 0.103692648936058 2222 3571 2831 3538 3155 3316 2970 3264 3505 2071 3305 3665 M15296 GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 13/51 Gene Ontology BP GO:0035249 0.0673614139425753 0.15131061680473 3795 3044.72727272727 3264 0.00631972064422294 773 1.1012409658332 1.1012409658332 1 3.42825095017479 3795 3958 2551 3893 3625 2765 3264 773 2680 1958 4230 3666 M12013 GO_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. 21/47 Gene Ontology BP GO:0046513 0.667434366415499 0.758975695142582 3600 2994.90909090909 3265 0.0952380952380952 1646 0.403096937997746 0.37486274264921 1 0.183262036316113 3600 1646 2350 2331 3471 2107 3477 4266 3039 3392 3265 3667 M14220 GO_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_METHYLATION.html The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. 16/38 Gene Ontology BP GO:0051568 0.0774407751826743 0.158445571591463 3950 2657.81818181818 3265 0.00730082804981486 520 0.237528108451156 -0.268458398594278 -1 0.721401947187698 1932 4142 3265 4436 3948 642 1784 944 3674 3949 520 3668 M10818 GO_RNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_STABILIZATION.html Prevention of degradation of RNA molecules. 26/44 Gene Ontology BP GO:0043489 0.982992683943975 0.999999998379914 4575 3368.09090909091 3266 0.30952380952381 2460 1.16186250822327 -1.16186250822327 -1 2.92608287341347e-09 4575 3324 2548 3266 4190 2752 2790 3961 3941 2460 3242 3669 M13848 GO_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLESION_SYNTHESIS.html The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. 21/55 Gene Ontology BP GO:0019985 0.505624391979193 0.622049298346421 1830 2918.18181818182 3266 0.0620342006342691 1431 0.759980613502947 -0.759980613502947 -1 0.594766035386105 1828 3658 3052 3636 3856 1458 3266 2104 3960 3851 1431 3670 M15444 GO_MYOTUBE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_CELL_DEVELOPMENT.html The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 11/39 Gene Ontology BP GO:0014904 0.428482205359668 0.54790495166206 2835 3162.63636363636 3266 0.0495882517212739 1337 0.574972452582313 0.378734254596136 1 0.570275867090107 2834 3360 1337 3677 3139 3407 3044 3266 2731 4273 3721 3671 M11535 GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. 12/36 Gene Ontology BP GO:1902932 0.124474478318915 0.218253399862055 4370 2873.72727272727 3267 0.0120119083035808 969 1.38916827744188 -1.38916827744188 -1 3.48569320287478 4366 1339 969 1980 4221 3331 4620 4137 1521 1860 3267 3672 M12534 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/43 Gene Ontology BP GO:0043267 0.0839184282471183 0.158445571591463 4500 2936.54545454545 3268 0.00793650793650794 1206 1.42279293755586 -1.42279293755586 -1 4.32119635229815 4499 1696 2065 2224 3268 4025 4111 3419 1206 2237 3552 3673 M13490 GO_INOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. 5/13 Gene Ontology BP GO:0006020 0.199340986125463 0.306470264430637 1815 2841.81818181818 3270 0.0219867023964554 736 0.408602794792145 0.398870488067059 1 0.796605747903806 1814 3484 4085 3623 3048 1771 736 3270 3909 3753 1767 3674 M11114 GO_MITOCHONDRIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSPORT.html Transport of substances into, out of or within a mitochondrion. 120/271 Gene Ontology BP GO:0006839 0.290889059610304 0.409520286164537 3360 2992.81818181818 3272 0.030766174311848 1363 1.32134000209084 1.70496045265207 1 1.94466656870359 3356 2521 3327 3505 1962 1363 4295 3958 3272 2835 2527 3675 M13743 GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 253/528 Gene Ontology BP GO:0042176 0.0848737493457861 0.159694043832238 4520 3172.45454545455 3272 0.00803060324177724 334 1.10323099245138 1.20710280054333 1 3.33637341284619 4520 3933 3272 3662 3021 334 4176 4268 2973 2696 2042 3676 M11476 GO_MALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GAMETE_GENERATION.html Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. 215/832 Gene Ontology BP GO:0048232 0.0411220711185788 0.106963460058018 3915 2971.90909090909 3274 0.00381013224770438 488 1.19492523706803 1.52290258503239 1 4.40313373485141 3914 4530 3160 4519 877 488 3631 3922 3274 2788 1588 3677 M13607 GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. 12/22 Gene Ontology BP GO:0034315 0.00405638944545983 0.0216729760589989 3530 2946.90909090909 3275 0.000369444366742002 223 0.764161110170704 -0.764161110170704 -1 4.8268826654308 3529 3330 3170 2749 223 2959 3671 2405 3318 3787 3275 3678 M12430 GO_DNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_MODIFICATION.html The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. 35/83 Gene Ontology BP GO:0006304 0.157133632835989 0.258740097879113 1445 2504.36363636364 3276 0.0154204907334869 541 0.55936453995665 -0.55936453995665 -1 1.24664002394779 1443 3276 3387 3586 3654 541 1938 1666 3850 3485 722 3679 M10589 GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 49/133 Gene Ontology BP GO:0032481 0.35943518917414 0.479556776820555 2725 3025.54545454545 3278 0.0396825396825397 1484 1.00891661677385 1.00891661677385 1 1.22228059796167 2724 2880 3278 3337 3934 4098 1484 3450 2316 2312 3468 3680 M12680 GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING.html Any process that activates or increases the frequency, rate or extent of telomere capping. 5/20 Gene Ontology BP GO:1904355 0.632427457617131 0.731410454716618 2990 3372.45454545455 3278 0.0952380952380952 2591 0.435378282746365 -0.155278082871323 -1 0.224490488425119 2988 3872 3947 3278 4079 2811 3204 3771 3005 3551 2591 3681 M10984 GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 67/163 Gene Ontology BP GO:0007249 0.726270090971166 0.809038395484434 3170 3455.54545454545 3279 0.111111111111111 2821 0.975157604060794 0.975157604060794 1 0.340655618529014 4018 3168 3279 4102 3582 3961 3169 2827 3178 2821 3906 3682 M11569 GO_SARCOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOMERE_ORGANIZATION.html The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. 26/61 Gene Ontology BP GO:0045214 0.19887232337054 0.306460529469592 3295 2443.90909090909 3279 0.0199559139384569 603 0.46466178204994 -0.513617536887759 -1 0.905921822715041 1459 3465 1095 3338 3814 603 1088 3292 3279 3291 2159 3683 M16293 GO_UTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. 6/13 Gene Ontology BP GO:0046051 0.829141633052528 0.899898383976024 2615 3218.45454545455 3279 0.161962167145257 1857 0.216571098689291 -0.298521826902736 -1 0.0376560796888701 2614 2907 4542 3733 3279 1857 2297 3312 4001 4462 2399 3684 M16815 GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. 25/91 Gene Ontology BP GO:0045671 0.298735036746822 0.413174493778819 3850 3346.27272727273 3279 0.0317460317460317 1819 1.29644110978073 1.29644110978073 1 1.88903599672661 3849 3279 1819 3142 3081 4251 4008 4331 2018 2446 4585 3685 M14934 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. 22/45 Gene Ontology BP GO:0006383 0.0839184282471183 0.158445571591463 3180 3124 3280 0.00793650793650794 1231 0.94753436197982 -0.818634081759665 -1 2.87777786950079 3176 3280 3380 3322 3014 4078 2699 3794 1231 2364 4026 3686 M11531 GO_BLASTOCYST_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_FORMATION.html The initial formation of a blastocyst from a solid ball of cells known as a morula. 13/34 Gene Ontology BP GO:0001825 0.574757543447499 0.682472387017387 2860 3342.63636363636 3281 0.0747913326726587 2510 0.275163527722069 0.314707091572947 1 0.173294001364624 2858 3847 2631 3792 2510 3736 4041 2794 4531 3281 2748 3687 M14743 GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. 46/129 Gene Ontology BP GO:0002702 0.174992600774265 0.275794516427329 3285 2901.18181818182 3282 0.0173355189761367 1364 1.76654498878037 1.76654498878037 1 3.75115969781679 3282 3527 1364 3553 1635 4629 3429 1845 2107 2226 4316 3688 M14751 GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. 9/19 Gene Ontology BP GO:0071071 0.410664832544891 0.532900172584105 2810 3141 3282 0.0515024012375095 1749 0.467197860232315 0.563769369653065 1 0.484767761555331 2808 1985 4286 2770 2280 4028 1749 3282 3876 4090 3397 3689 M15056 GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. 31/101 Gene Ontology BP GO:0042475 0.161746995382127 0.259051845311907 3465 2586.27272727273 3282 0.0159116246036035 564 1.205013118394 -1.23499418612913 -1 2.6831868600006 3465 627 1039 564 4335 3282 4136 3902 1795 952 4352 3690 M10186 GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 44/102 Gene Ontology BP GO:0070373 0.194396023453004 0.301563894718442 3525 3307.18181818182 3283 0.0194593560649272 1700 0.803844625361199 0.803844625361199 1 1.58854945078071 3525 3380 2736 2999 1700 3283 4400 4236 2689 2971 4460 3691 M12732 GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 25/101 Gene Ontology BP GO:0050805 0.0839184282471183 0.158445571591463 3130 3137.54545454545 3283 0.00793650793650794 1229 1.77228865595639 1.77228865595639 1 5.38265763994863 3128 3655 2718 3283 3405 4184 4498 2073 1229 2439 3901 3692 M15765 GO_VESICLE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING.html The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. 25/63 Gene Ontology BP GO:0048278 0.441456937184958 0.560482515545464 3945 2895.81818181818 3285 0.0515702875706807 1032 0.481449101090274 -0.481449101090274 -1 0.459503057134999 2416 3534 3285 3779 3944 1032 2279 1685 3942 4347 1611 3693 M16321 GO_GLUCOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. 20/52 Gene Ontology BP GO:0006007 0.512801186246554 0.627050688219243 4205 3083.36363636364 3285 0.0632802942625103 1282 0.422082264161338 -0.387392316205676 -1 0.324752428763274 4205 1282 2235 2007 2403 2005 3346 4610 3285 4471 4068 3694 M11042 GO_POSITIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOR_SIGNALING.html Any process that activates or increases the frequency, rate or extent of TOR signaling. 18/31 Gene Ontology BP GO:0032008 0.751985672431077 0.832094727620946 3575 3364.18181818182 3286 0.119047619047619 2188 1.45023161899474 1.45023161899474 1 0.439436026470867 3571 3007 3098 3286 3627 4317 3561 3281 3212 2188 3858 3695 M15390 GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 9/22 Gene Ontology BP GO:0046135 0.644160870095074 0.740489952921869 3570 3128.27272727273 3286 0.0981685629383179 1622 1.0296882537552 -1.0296882537552 -1 0.509987696693895 3566 3963 4394 3367 2697 1782 2838 3286 4143 1622 2753 3696 M10147 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT.html The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. 7/15 Gene Ontology BP GO:0010248 0.214139132665174 0.322775948981753 4255 2891.09090909091 3287 0.0238095238095238 975 1.38933387508025 1.38933387508025 1 2.58989858522316 4255 982 3543 975 3287 3385 3261 4632 1655 1391 4436 3697 M10862 GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. 45/87 Gene Ontology BP GO:0006283 0.872354454178706 0.933904019080408 2630 3489 3288 0.1706692133105 1922 0.159275520438709 -0.174999836023172 -1 0.0179547717462104 2626 4609 3488 4566 4449 1922 3288 3213 4514 3105 2599 3698 M14164 GO_REGULATION_OF_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTON_TRANSPORT.html Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/21 Gene Ontology BP GO:0010155 0.451298778932717 0.570481957687069 2435 2868.18181818182 3288 0.0582544154257246 1190 0.407041046490997 -0.460373920893312 -1 0.376620944853788 2433 1913 4195 3288 3463 1705 1190 4015 3608 3933 1807 3699 M11565 GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 32/95 Gene Ontology BP GO:0051196 0.177821502460332 0.279493986433081 4130 3082.54545454545 3290 0.01764231549764 1353 0.385847122419596 -0.454215919433847 -1 0.810849356070932 4130 4090 2186 4149 1645 1353 3692 3393 3137 3290 2843 3700 M13243 GO_TOXIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. 3/16 Gene Ontology BP GO:0009404 0.098497082535677 0.180403137756666 2620 3196.45454545455 3290 0.0103156251925379 1350 0.408752238928021 0.319971454650209 1 1.1539787379296 2618 2547 4036 3457 1350 2973 3290 4074 4255 3682 2879 3701 M10367 GO_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_SECRETION.html The controlled release of acid by a cell or a tissue. 28/113 Gene Ontology BP GO:0046717 0.578702654422662 0.68596283494624 1895 3159.36363636364 3291 0.0755749571747097 1894 0.39470073440508 0.410474633014451 1 0.245257495233776 1894 3626 2015 3697 2515 3291 3430 4285 3891 3009 3100 3702 M11579 GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of activated T cell proliferation. 20/43 Gene Ontology BP GO:0046006 0.145167552126214 0.24707219373974 2905 3036.81818181818 3292 0.0141578933270018 586 0.410277499475844 -0.323749683528239 -1 0.945582921672557 2902 3628 1544 3693 4591 2825 586 3088 3797 3292 3459 3703 M14356 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING.html Any cell surface receptor signaling pathway that is involved in cell-cell signaling. 24/99 Gene Ontology BP GO:1905114 0.298735036746822 0.413174493778819 4210 2993.63636363636 3293 0.0317460317460317 796 1.09257959149497 -1.3261771808088 -1 1.5919906905265 4207 796 2276 1764 4594 3293 3355 3855 2109 2417 4264 3704 M14810 GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. 39/107 Gene Ontology BP GO:0048024 0.291842199171739 0.410139707445999 1510 3042.45454545455 3293 0.0308846812217787 779 0.222776313651358 -0.250415997666339 -1 0.327313348860915 1509 4451 3293 4462 3424 779 2524 3103 4299 4102 1521 3705 M14388 GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. 10/28 Gene Ontology BP GO:0014874 0.316644870932477 0.434707905304403 3295 3195.36363636364 3294 0.0340206113540972 2033 0.409711377865977 -0.352689543456426 -1 0.562673903622583 3294 3760 2272 3588 2033 4298 2588 2824 2668 3997 3827 3706 M11398 GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of T cell proliferation. 53/158 Gene Ontology BP GO:0042102 0.560078701510024 0.669010911013903 4350 3156.18181818182 3295 0.0719325426609564 1472 0.895121045658977 0.847808867288674 1 0.593131034100733 4350 2287 1472 1880 2651 3676 3349 4424 3295 3242 4092 3707 M11429 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION.html Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. 12/23 Gene Ontology BP GO:0010569 0.978161938897681 0.999999998379914 3575 3311.27272727273 3295 0.293650793650794 2642 0.3092101351244 -0.351490233996447 -1 6.48880153054764e-10 3574 2896 2732 2703 3466 2642 3658 4297 3912 3249 3295 3708 M13033 GO_RESPONSE_TO_PROTOZOAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROTOZOAN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. 11/25 Gene Ontology BP GO:0001562 0.643852668828379 0.740318955267499 3445 2803 3296 0.0895857157472483 1348 0.369725202767556 -0.321859669768876 -1 0.183259590313142 3442 3296 1974 3686 3518 1348 1661 2631 3736 3631 1910 3709 M16057 GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT.html The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. 6/21 Gene Ontology BP GO:0060525 0.435603872835285 0.554111994951843 3315 3174 3296 0.0555947286449859 1168 0.432429073183533 -0.400147739945458 -1 0.420866427898238 3315 2326 4502 2801 4151 2241 1168 3036 3669 4409 3296 3710 M10943 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html The directed movement of a protein to a specific location on a chromosome. 11/20 Gene Ontology BP GO:0070199 0.514011397665828 0.627050688219243 3955 3221.90909090909 3297 0.0634920634920635 1777 1.33403223803043 -1.33403223803043 -1 1.02641178342582 3954 2860 2520 3164 3774 3297 4407 3566 2660 1777 3462 3711 M16035 GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION.html Any process that modulates the frequency, rate or extent of protein polyubiquitination. 8/20 Gene Ontology BP GO:1902914 0.0429187122183729 0.110034003771345 1095 2766.81818181818 3299 0.00437708759916894 346 0.306008244584587 0.364257493609717 1 1.11332069008055 1092 3898 4497 3955 3299 917 346 2278 4294 4403 1456 3712 M11237 GO_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_TRANSPORT.html The directed movement of substances into, out of or within a vacuole. 156/316 Gene Ontology BP GO:0007034 0.574322439101707 0.682472387017387 4120 3189.09090909091 3300 0.0747053121830916 1473 1.20078503785056 1.37349522913023 1 0.756237012493361 4117 3734 3238 3672 2508 1473 4033 3438 3300 2828 2739 3713 M12688 GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. 4/16 Gene Ontology BP GO:2001053 0.632700285295922 0.731410454716618 2070 2964.27272727273 3300 0.0953052728829774 1533 0.396432770680833 -0.512524525585805 -1 0.204409337437756 2066 3770 3951 3300 4120 1764 1533 2447 3929 3555 2172 3714 M15034 GO_RNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYADENYLATION.html The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. 22/35 Gene Ontology BP GO:0043631 0.0355077347022313 0.0963544197676564 3220 3094.72727272727 3300 0.00328128351649949 806 0.824416974526559 0.824416974526559 1 3.17982140651213 3217 3535 3300 3878 806 3654 1864 2868 3049 4161 3710 3715 M15697 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction. 45/122 Gene Ontology BP GO:0055117 0.466738071388703 0.580826820010117 3535 3128.81818181818 3301 0.0555555555555556 857 1.24174626568581 1.27574452506151 1 1.11215730643876 3533 3740 1724 3149 4276 2968 3867 3301 2599 857 4403 3716 M13981 GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphatidylinositol. 13/23 Gene Ontology BP GO:0046856 0.027054751279268 0.0804194687513709 4265 3195.36363636364 3302 0.00249030031408853 696 0.234281391847513 -0.262515451693476 -1 0.973454964686707 4264 3018 3302 2643 696 2707 3254 4061 3717 3896 3591 3717 M10173 GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 7/20 Gene Ontology BP GO:0061000 0.0256142788772682 0.0781900702348168 2680 2809.54545454545 3303 0.00259144002242152 261 0.422814262852718 -0.383111765761569 -1 1.77641732611246 2679 3303 3548 3671 4171 994 261 4493 3365 2966 1454 3718 M14104 GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. 8/18 Gene Ontology BP GO:0042754 0.393171308324758 0.514803830950888 3660 3219.63636363636 3303 0.0487238451153862 1968 0.425534669815536 0.404894328299276 1 0.465773237617144 3657 2578 4188 2824 2238 3303 1968 3920 3100 3923 3717 3719 M14802 GO_ACETYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. 7/12 Gene Ontology BP GO:0006085 0.0594301579638394 0.138382258488519 1215 2698.27272727273 3304 0.00610820584090201 578 0.381887704693773 0.470996561843855 1 1.24507471331574 1211 3304 4295 3631 4413 2279 578 763 4071 4100 1036 3720 M15700 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. 21/48 Gene Ontology BP GO:1900408 0.879680929286225 0.937424501876507 3305 3429.27272727273 3305 0.175113791387545 2449 0.315878274675708 -0.250590431133613 -1 0.0336489800493205 3305 2669 2849 3199 4073 4532 2619 2449 3757 4331 3939 3721 M11796 GO_MEMBRANE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a membrane. 12/40 Gene Ontology BP GO:0071709 0.232850105696956 0.342669743502683 4450 3220.36363636364 3306 0.0238095238095238 1845 1.51935086267539 -1.51935086267539 -1 2.68246634387331 4448 4177 2138 2908 3306 3626 3990 3936 1845 1863 3187 3722 M11125 GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. 35/118 Gene Ontology BP GO:0045824 0.232850105696956 0.342669743502683 3310 2950.54545454545 3307 0.0238095238095238 1313 1.5272541759897 1.5272541759897 1 2.69641991608164 3307 3318 1835 2666 3326 4222 4560 1313 1860 1898 4151 3723 M14330 GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of T cell mediated immunity. 39/118 Gene Ontology BP GO:0002709 0.722989400651445 0.807514983696093 2715 3429.09090909091 3307 0.11014785150175 2600 0.298522240803524 0.351149894215502 1 0.10521146642358 2712 4163 2600 4219 2784 3265 2640 3307 3937 3981 4112 3724 M16698 GO_ASTROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DEVELOPMENT.html The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 11/39 Gene Ontology BP GO:0014002 0.35943518917414 0.479556776820555 3955 3132.36363636364 3307 0.0396825396825397 1497 0.483489824121548 -0.310195596035768 -1 0.585737435004663 3955 1497 2236 2342 3307 2144 3699 3817 2262 4569 4628 3725 M14187 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE.html The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. 7/15 Gene Ontology BP GO:1990126 0.428237628440665 0.547743060289258 2525 2992.90909090909 3309 0.0543693133592336 1457 0.277897023152711 -0.287899057713764 -1 0.27576243955205 2522 3669 4200 3535 2309 1719 3309 1881 4380 3941 1457 3726 M11659 GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 17/33 Gene Ontology BP GO:0046134 0.985482933233424 0.999999998379914 3310 3542.18181818182 3310 0.319390385977306 2625 0.223390879910398 -0.262792520664113 -1 4.19680249790292e-10 2819 4557 2756 4587 3867 2625 3310 3602 4616 3308 2917 3727 M16029 GO_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group. 34/62 Gene Ontology BP GO:0043967 0.448982953800645 0.56827337703011 3065 3055.72727272727 3310 0.0527392369010719 1048 0.827888949868591 -0.84157669908996 -1 0.771310810632251 3065 4285 3397 4256 3310 1048 1871 3846 2601 4401 1533 3728 M16191 GO_PEPTIDYL_LYSINE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_METHYLATION.html The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. 38/84 Gene Ontology BP GO:0018022 0.00371478606793294 0.0203633432271696 1255 2552.45454545455 3310 0.000338279408887886 92 0.258739896036574 -0.296273993698167 -1 1.66093637422916 1255 4126 3310 4579 3484 120 1480 1383 3811 4437 92 3729 M11670 GO_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_PRODUCTION.html The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 11/37 Gene Ontology BP GO:0032612 0.650205894177492 0.745777165678383 2545 3289.18181818182 3311 0.0910742485352971 1970 0.337050767387837 0.426505662944451 1 0.162982516185871 2542 4045 2273 4017 4583 2858 3602 1970 3827 3311 3153 3730 M11920 GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. 33/99 Gene Ontology BP GO:1990542 0.488902815198677 0.605649885530271 2795 3171.18181818182 3313 0.0591934828954387 1716 0.246074526916348 -0.260343286320753 -1 0.203417641003761 2793 2921 3334 3447 2363 1716 3313 4582 4280 3369 2765 3731 M15323 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. 5/25 Gene Ontology BP GO:0002689 0.206742371118226 0.315136188149022 1550 2727.72727272727 3313 0.0228945722920309 744 0.800508376728112 -0.800508376728112 -1 1.52386165446963 1549 3556 4386 3313 3586 814 744 2603 3728 4237 1489 3732 M11687 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 14/47 Gene Ontology BP GO:0048147 0.529695600152769 0.641799757700759 2380 3093.63636363636 3314 0.0662808273987253 1163 0.235792932690279 -0.233034495395134 -1 0.172383349441788 2376 4509 3023 4105 3605 1163 2088 3618 4338 3314 1891 3733 M14454 GO_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_POTENTIATION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. 15/63 Gene Ontology BP GO:0060291 0.497785857476758 0.614522663191861 2375 3385.72727272727 3314 0.0606918613332306 2373 0.261533959312066 0.278336315996967 1 0.209926783631522 2373 3987 3122 4283 2377 3233 3314 3897 3489 4022 3146 3734 M15474 GO_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of DNA replication. 86/211 Gene Ontology BP GO:0006275 0.667434366415499 0.758975695142582 3315 3342.72727272727 3314 0.0952380952380952 1904 1.45895769169445 1.45895769169445 1 0.66329344746175 3314 4359 1996 3989 3084 3225 3771 3478 3044 1904 4606 3735 M11691 GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. 12/19 Gene Ontology BP GO:2000104 0.720455751670727 0.805266262640151 1965 3258 3315 0.109411006082489 1636 0.185308576953425 0.19362878376283 1 0.06616221161028 1962 4624 3128 4292 3479 3370 1636 2969 4528 3315 2535 3736 M16462 GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT.html The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. 81/166 Gene Ontology BP GO:0030705 0.0287122578343793 0.0835459186441196 4090 2618.90909090909 3316 0.00264490684346071 176 0.697762624785416 -0.697762624785416 -1 2.85537934079351 1483 4086 3316 4089 4026 176 1931 1447 3341 4509 404 3737 M16577 GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING.html The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. 29/65 Gene Ontology BP GO:0061077 0.284772603254795 0.403355459704702 3320 3311.90909090909 3316 0.0300091238752918 762 0.214327000590765 -0.215776664156031 -1 0.320792478827711 3316 4288 3313 4452 4167 762 2534 2889 4474 4536 1700 3738 M13663 GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. 61/139 Gene Ontology BP GO:0051351 0.130150502621122 0.226071374362092 415 2542.90909090909 3317 0.0125959147663852 415 0.649810243057386 -0.649810243057386 -1 1.59279973619656 415 3941 3384 3751 3317 439 1815 1929 3995 3800 1186 3739 M10085 GO_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. 27/70 Gene Ontology BP GO:0002181 0.687498682864874 0.777855898013402 3050 3340.09090909091 3318 0.100342010496949 1439 0.194318929115376 -0.266559241767036 -1 0.0804730527233628 3048 4501 3393 4512 4401 1439 3318 2915 4101 2950 2163 3740 M11271 GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 46/224 Gene Ontology BP GO:0038094 0.431924429190852 0.551243849569304 4360 3447.27272727273 3319 0.0501100713015808 2251 0.885892611905994 -0.625059557561618 -1 0.869783722943699 4356 4363 2358 4352 2251 3319 3162 4427 2863 2716 3753 3741 M12906 GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 26/75 Gene Ontology BP GO:0086065 0.232850105696956 0.342669743502683 3425 3076.18181818182 3319 0.0238095238095238 1448 1.26454268131947 -1.13975148755868 -1 2.23259371243101 3424 2255 3103 2228 4289 3391 3319 4082 1897 1448 4402 3742 M15080 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes outside the context of DNA replication. 34/63 Gene Ontology BP GO:0006336 0.648695259376104 0.744228339333642 1150 2806.72727272727 3319 0.090718099562939 1148 0.416672695829558 -0.485976659889174 -1 0.202912092982919 1148 3319 1585 3811 3533 2085 3371 2018 3408 4177 2419 3743 M16895 GO_RECEPTOR_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CLUSTERING.html The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. 23/64 Gene Ontology BP GO:0043113 0.816521443770307 0.888471774882948 4615 3280.45454545455 3319 0.142857142857143 1849 1.51935086267539 -1.51935086267539 -1 0.296182625880509 4613 3839 1849 2755 3096 3603 3662 3743 3319 2399 3207 3744 M10637 GO_SEROTONIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. 4/21 Gene Ontology BP GO:0042428 0.00375972410067538 0.0204887312199951 4475 3096.27272727273 3320 0.000376610027499158 229 1.03069309216194 -1.03069309216194 -1 6.60592724886706 4475 2800 3613 3320 229 4500 2587 4223 2937 1088 4287 3745 M16465 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures, occurring outside the context of DNA replication. 34/63 Gene Ontology BP GO:0034724 0.648695259376104 0.744228339333642 1150 2835.54545454545 3320 0.090718099562939 1149 0.416672695829558 -0.485976659889174 -1 0.202912092982919 1149 3320 1586 3812 3534 2086 3372 1992 3409 4511 2420 3746 M12044 GO_HISTONE_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_EXCHANGE.html The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. 33/164 Gene Ontology BP GO:0043486 0.606636802543293 0.709474729019775 1630 2840.09090909091 3321 0.08132252947017 1547 0.407849261158666 -0.465041697631511 -1 0.230768735153303 1626 3321 1547 3995 3772 2209 3559 1896 3381 3402 2533 3747 M12431 GO_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MEMBRANE.html A process in which a protein is transported to, or maintained in, a specific location in a membrane. 223/589 Gene Ontology BP GO:0072657 0.557443745451391 0.666249592815201 2300 3163 3322 0.0714285714285714 1866 1.30935623391386 1.4087935788966 1 0.876541809112378 2296 4529 3439 4048 2738 4116 1866 3322 2750 1985 3704 3748 M10335 GO_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMMONIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. 27/89 Gene Ontology BP GO:0060359 0.258772046594143 0.37405934381588 4640 3166.63636363636 3323 0.0268552693574453 1166 0.819929079056374 -0.819929079056374 -1 1.32914358506008 4640 3323 1166 3518 2308 2598 3850 3842 3936 3003 2649 3749 M13506 GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. 11/28 Gene Ontology BP GO:0051570 0.709310491490898 0.795297901954175 3490 3112.63636363636 3323 0.106240130328884 1843 0.334229187327835 -0.385617637173059 -1 0.126195664295654 3490 2398 2560 3323 4496 1912 2733 4076 3648 3760 1843 3750 M10108 GO_MULTICELLULAR_ORGANISM_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_AGING.html An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). 16/39 Gene Ontology BP GO:0010259 0.957184684804901 0.995566418357786 3415 3385.81818181818 3324 0.249069191859249 2379 0.292870077409573 -0.227224532684042 -1 0.00214528868433983 3415 4463 2379 4503 3885 2754 2788 3324 4152 2956 2625 3751 M10199 GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. 48/104 Gene Ontology BP GO:0006354 0.743667318528553 0.8250531325993 2640 3289.27272727273 3324 0.116401627378776 1579 0.189778076487405 -0.219408086714666 -1 0.0601635957683107 2637 4543 3477 4552 3324 1579 3707 2960 4128 2973 2302 3752 M11714 GO_PROTEIN_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLATION.html The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 60/135 Gene Ontology BP GO:0006479 0.00220220997342434 0.0139826785130856 1130 2456.72727272727 3324 0.000200401589985342 71 0.241200595443336 -0.272804199686783 -1 1.69781857220071 1129 4280 3436 4497 3556 85 1443 1335 3868 3324 71 3753 M12063 GO_PEPTIDYL_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_AMINO_ACID_MODIFICATION.html The alteration of an amino acid residue in a peptide. 446/1025 Gene Ontology BP GO:0018193 0.0438462474293959 0.112051654492429 4450 2912.09090909091 3324 0.00406775416653672 227 1.34159135508781 1.49474971638639 1 4.84079781135811 4447 4029 3324 4221 997 227 3922 4472 2440 2780 1174 3754 M11726 GO_PEPTIDYL_ARGININE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_MODIFICATION.html The modification of peptidyl-arginine. 9/19 Gene Ontology BP GO:0018195 0.409895864238855 0.53249762105792 3495 3325.81818181818 3327 0.0513787132701522 2277 0.166941363272131 -0.157624453173555 -1 0.173427491301207 3495 3722 3795 3962 2277 2417 2994 3315 4329 3327 2951 3755 M12702 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 12/37 Gene Ontology BP GO:0090281 0.161385165508919 0.258740097879113 4545 3301.45454545455 3328 0.0158730158730159 1587 1.29994081892301 1.29994081892301 1 2.89714155618358 4544 3818 2336 3328 2333 3213 4404 4302 1587 1871 4580 3756 M14436 GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. 16/59 Gene Ontology BP GO:0046597 0.788406011219041 0.864873500594784 3985 3233.81818181818 3328 0.131675368879628 2018 0.350836215307702 -0.395162575022535 -1 0.083961249513781 3985 3328 2369 3422 3099 2678 2584 4006 4069 4014 2018 3757 M14908 GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of cellular protein catabolic process. 168/354 Gene Ontology BP GO:1903362 0.191248631664858 0.29727752751794 3840 3020.72727272727 3328 0.0191117141699584 581 0.957985539009296 1.10763097381636 1 1.91576930519917 3837 3733 3328 2981 3359 581 3845 3797 2988 2850 1929 3758 M11730 GO_RRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_TRANSCRIPTION.html The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. 11/27 Gene Ontology BP GO:0009303 0.161220571778038 0.258740097879113 3720 2975.27272727273 3329 0.0158554580582717 1127 0.260326666460165 -0.335237215729324 -1 0.58018272249147 3719 3435 3213 3638 1576 2341 4186 1127 3548 3329 2616 3759 M10769 GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein. 74/160 Gene Ontology BP GO:0042787 0.205313368960949 0.313575648712397 3435 3267.72727272727 3332 0.020674866033733 609 0.680644994905029 -0.680644994905029 -1 1.30125777932239 3433 4541 3332 4459 4279 609 3193 2738 4429 3088 1844 3760 M13500 GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 10/29 Gene Ontology BP GO:0030206 0.960386799771781 0.998002665922198 2220 3333.09090909091 3332 0.254357072908406 2218 0.331475408243558 0.436208024609609 1 0.00109251541899389 2218 3332 2319 4182 3352 4087 3102 2879 4173 3757 3263 3761 M16526 GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 3/17 Gene Ontology BP GO:0043950 0.105065280685184 0.189591176922391 2675 3115.72727272727 3332 0.0110390676049868 525 0.491299777342334 0.650048068078531 1 1.34679155440548 2671 3583 4575 3332 3419 3095 525 2479 4359 4522 1713 3762 M10629 GO_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 31/53 Gene Ontology BP GO:0070670 0.824053590862629 0.895199069343749 4560 3291.18181818182 3334 0.146117291695418 1771 0.355277082216429 -0.375064438011535 -1 0.0648398940429231 4560 3743 1771 3334 3656 3982 2461 2901 3549 3064 3182 3763 M12537 GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE.html Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. 7/13 Gene Ontology BP GO:0099500 0.0681743129362884 0.152545472526535 3475 3215.36363636364 3334 0.00703608133672807 1164 0.210523127926032 -0.275423365653574 -1 0.652554488030822 3474 3159 3926 2885 1164 3088 2722 4539 3564 3514 3334 3764 M15910 GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE.html Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. 7/13 Gene Ontology BP GO:0031629 0.0681743129362884 0.152545472526535 3475 3344.18181818182 3335 0.00703608133672807 1165 0.210523127926032 -0.275423365653574 -1 0.652554488030822 3475 3160 4478 2886 1165 3089 2723 4535 3565 4375 3335 3765 M12046 GO_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). 83/171 Gene Ontology BP GO:0045333 0.390810442224519 0.512290480871948 1590 2802.63636363636 3336 0.0440569040977972 947 0.564322045552235 -0.564322045552235 -1 0.622237292360186 1586 3523 3483 4106 2324 947 2138 3336 3873 3403 2110 3766 M14123 GO_RNA_SECONDARY_STRUCTURE_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SECONDARY_STRUCTURE_UNWINDING.html The process in which a secondary structure of RNA are broken or 'melted'. 22/45 Gene Ontology BP GO:0010501 0.551723570762893 0.663134690230392 2310 3132.90909090909 3336 0.0703438323423536 1944 0.235163238119884 -0.228765322806825 -1 0.159245532749201 2309 3426 3336 3383 2457 1944 4039 3117 4102 3927 2422 3767 M11774 GO_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSPORT.html The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. 17/32 Gene Ontology BP GO:0006862 0.173412144223183 0.274047850792458 3365 3161.45454545455 3337 0.0171645334231045 1135 0.23684664361236 -0.295914758760227 -1 0.505411258773846 3361 4301 3242 4383 3879 2129 2373 1135 3791 3337 2845 3768 M13258 GO_FC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 108/363 Gene Ontology BP GO:0038093 0.320756974414892 0.439184497849703 3465 3195.09090909091 3337 0.034550498743986 841 0.808553107384281 0.900299882295612 1 1.09676406176354 3464 4595 3337 4597 2997 841 4355 3803 3114 2887 1156 3769 M16751 GO_HISTONE_H3_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_DEACETYLATION.html The modification of histone H3 by the removal of one or more acetyl groups. 15/23 Gene Ontology BP GO:0070932 0.35943518917414 0.479556776820555 3590 3416.54545454545 3337 0.0396825396825397 2258 0.327542845580876 0.313374560492008 1 0.396811052943373 3590 2889 3057 2794 3002 4058 3499 3337 2258 4581 4517 3770 M11775 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of hair follicle development. 7/18 Gene Ontology BP GO:0051797 0.720093500158743 0.805055170054669 2650 3310.18181818182 3338 0.119556891692277 1693 0.364459748701766 0.461506501133107 1 0.130283513971108 2648 3966 3802 3833 3329 2917 1693 3573 4325 3338 2988 3771 M16726 GO_PHAGOCYTOSIS_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_RECOGNITION.html The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. 6/130 Gene Ontology BP GO:0006910 0.598881260040338 0.702350515374411 2655 3358.45454545455 3338 0.0873015873015873 1343 1.49234186417521 1.49234186417521 1 0.869223366881909 2652 3077 4611 3358 4501 4332 3705 3101 2925 1343 3338 3772 M13819 GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that activates or increases the frequency, rate or extent of chromatin modification. 48/111 Gene Ontology BP GO:1903310 0.0488206690469685 0.12037937673132 4245 3141.45454545455 3340 0.00453990544925735 959 1.01494101111454 -0.9282856402567 -1 3.54221699472575 4241 4124 2534 3757 959 2268 4065 3853 3340 2736 2679 3773 M11150 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. 60/110 Gene Ontology BP GO:0048010 0.35943518917414 0.479556776820555 3670 3187.63636363636 3341 0.0396825396825397 1781 1.36044560232016 1.36044560232016 1 1.64815033939829 3667 2378 1781 2570 4249 3970 3341 3926 2283 2508 4391 3774 M14444 GO_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. 91/217 Gene Ontology BP GO:0035303 0.232850105696956 0.342669743502683 3305 3331.90909090909 3342 0.0238095238095238 1898 1.60329189230399 1.60329189230399 1 2.83066712645434 3302 4084 2275 3342 2569 3436 4527 4148 1898 2506 4564 3775 M10410 GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. 62/127 Gene Ontology BP GO:2000058 0.334509313296338 0.454795531957511 1780 2992.63636363636 3343 0.0363440697209863 860 0.257556326179834 -0.264954710805042 -1 0.334532958123534 1778 3940 3385 4107 3832 860 3343 2520 4171 3020 1963 3776 M11110 GO_NCRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of a non-coding RNA molecule. 10/22 Gene Ontology BP GO:0043628 0.816521443770307 0.888471774882948 3560 3414.72727272727 3343 0.142857142857143 2654 0.219620952094041 -0.170130837056685 -1 0.0428129615466702 3560 3857 3250 3939 3343 2654 3351 3964 3335 3169 3140 3777 M11144 GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. 10/23 Gene Ontology BP GO:0061099 0.607145188548066 0.709890483613365 4285 3388.09090909091 3343 0.081430529905678 2377 0.664904966411386 -0.664904966411386 -1 0.375573526398163 4284 3069 2377 2837 2576 3343 3816 4095 4084 3179 3609 3778 M11783 GO_AEROBIC_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AEROBIC_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. 33/63 Gene Ontology BP GO:0009060 0.788500867546354 0.864873500594784 2985 3318.36363636364 3343 0.131710763799024 1794 0.255745690781686 -0.232211547135382 -1 0.0612044218985141 2983 3592 3369 4204 2909 1794 3315 3689 4073 3343 3231 3779 M13986 GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. 28/88 Gene Ontology BP GO:0043471 0.144486455344915 0.246132854186195 3710 2981.18181818182 3344 0.0140865118922522 1489 0.401348057960535 -0.483311035317851 -1 0.927523100813877 3709 3909 2118 4027 1512 1489 3344 3582 2606 3897 2600 3780 M16356 GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. 28/88 Gene Ontology BP GO:0043470 0.144486455344915 0.246132854186195 3710 3045.18181818182 3345 0.0140865118922522 1490 0.401348057960535 -0.483311035317851 -1 0.927523100813877 3710 3910 2119 4028 1513 1490 3345 3695 2607 4479 2601 3781 M13738 GO_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NIK_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). 58/119 Gene Ontology BP GO:0038061 0.0839184282471183 0.158445571591463 3995 3119.54545454545 3347 0.00793650793650794 850 1.93660894790567 1.93660894790567 1 5.88171848532267 3994 4282 3222 3347 2826 1514 3612 4503 850 2786 3379 3782 M11222 GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. 15/31 Gene Ontology BP GO:1903392 0.557443745451391 0.666249592815201 3350 3262.90909090909 3349 0.0714285714285714 1841 1.19045135446987 1.19045135446987 1 0.796941547959902 3349 4335 1841 2351 4074 4166 3851 3122 2749 2063 3991 3783 M11864 GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE.html The movement of organelles or other particles from one location in the cell to another along microtubules. 67/133 Gene Ontology BP GO:0010970 0.00258496900846763 0.0157300276622742 1175 2362.63636363636 3349 0.000235273756032009 50 0.697762624785416 -0.697762624785416 -1 4.77612643918324 1174 4250 3349 4216 3912 50 1035 1125 3445 3357 76 3784 M12387 GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT.html The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. 30/62 Gene Ontology BP GO:0006893 0.379137664397638 0.500522085811269 4055 3301.27272727273 3350 0.0424060529967015 1858 0.481449101090274 -0.481449101090274 -1 0.549304303640985 4052 4255 3291 4429 2152 1858 4121 2481 3350 3476 2849 3785 M13975 GO_MUSCLE_ATROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ATROPHY.html A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. 5/18 Gene Ontology BP GO:0014889 0.804956120936968 0.878564003175915 4095 3466.63636363636 3351 0.150793650793651 2472 0.515263153789213 -0.496001839893727 -1 0.109970981211329 4095 2472 4168 2490 3012 4292 2852 2867 3351 3895 4639 3786 M16222 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 22/35 Gene Ontology BP GO:0090503 0.698152987361708 0.785443256680497 3885 3328.36363636364 3351 0.103174603174603 2284 1.35593454827845 1.35593454827845 1 0.539833838384308 3882 3351 2979 3825 2968 2284 4432 3820 3104 2372 3595 3787 M14957 GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM.html The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. 18/51 Gene Ontology BP GO:0001738 0.816521443770307 0.888471774882948 2925 3378.54545454545 3352 0.142857142857143 2206 1.46584243959724 1.46584243959724 1 0.285751680894194 3950 3750 2340 3352 4471 2922 4221 3690 3338 2206 2924 3788 M11910 GO_FOREBRAIN_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_REGIONALIZATION.html The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. 2/33 Gene Ontology BP GO:0021871 0.487485718526386 0.604216815568076 3070 3205.6 3353 0.0715786734612378 1822 0.31478327600344 -0.31478327600344 -1 0.261445080941146 3067 3338 3821 NA 4327 3178 3390 1822 3454 3368 2291 3789 M10795 GO_MALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. 6/30 Gene Ontology BP GO:0030539 0.579664844918709 0.686805482764382 3360 3021.63636363636 3357 0.083020616714319 1308 1.07272638267715 -1.07272638267715 -1 0.664395245496789 3357 2143 3637 1752 2592 3708 2864 4062 3523 1308 4292 3790 M12271 GO_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOSIS_I.html The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. 44/204 Gene Ontology BP GO:0007127 0.494931377276104 0.611649290575712 1630 3086.09090909091 3357 0.0602077624518508 1114 0.256088717953742 -0.255834855145753 -1 0.207534603043112 1628 4499 2518 4300 3423 1114 3357 2912 4564 3453 2179 3791 M10571 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. 11/23 Gene Ontology BP GO:1901017 0.415320710913563 0.535202348257472 4210 3461.36363636364 3358 0.0476190476190476 2369 0.39294872710198 -0.391887436871983 -1 0.404933904113689 4206 2535 2805 3122 4586 3742 4550 3358 2369 3051 3751 3792 M16224 GO_TRANSCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCYTOSIS.html The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. 6/12 Gene Ontology BP GO:0045056 0.804956120936968 0.878564003175915 3675 3452.81818181818 3358 0.150793650793651 2608 0.462725329625727 -0.33312133544198 -1 0.098757999959372 3672 2831 4530 3455 4045 2608 3029 2856 3358 4446 3151 3793 M16875 GO_TRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. 32/58 Gene Ontology BP GO:0006400 0.577721000963142 0.685149069596902 1575 3184.63636363636 3358 0.0753793481166843 1254 0.738664740866751 -0.738664740866751 -1 0.460433838301132 1572 4093 3358 4185 4571 1254 2924 2687 4135 4616 1636 3794 M11925 GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 8/23 Gene Ontology BP GO:0071732 0.25045239824016 0.36407341422325 1755 2850.18181818182 3360 0.0284169672486363 830 0.522360943238646 0.741936030448646 1 0.870072550114743 1751 3765 3825 3360 2863 2083 830 3429 3644 3372 2430 3795 M12917 GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. 8/17 Gene Ontology BP GO:0006044 0.986326770472851 0.999999998379914 2875 3439.27272727273 3360 0.348990823385306 2470 0.358023483607371 -0.319823179409222 -1 7.7924733839578e-10 2875 2470 3980 2903 4420 3186 2792 4029 4216 3601 3360 3796 M13565 GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. 20/52 Gene Ontology BP GO:0002726 0.653703353037902 0.749048536069837 2650 3448.72727272727 3360 0.0919042096889387 2646 0.270562869168842 -0.258117718398993 -1 0.128879750131942 3084 4174 2646 4285 2648 2774 3928 3360 4276 3774 2987 3797 M11986 GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 11/36 Gene Ontology BP GO:0051973 0.298735036746822 0.413174493778819 3790 3207.27272727273 3361 0.0317460317460317 1950 0.371672438403151 0.369770742296331 1 0.541561517661088 3786 2397 2867 2354 4042 4492 3361 2381 1950 3388 4262 3798 M16243 GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that activates or increases the rate of ATP hydrolysis by an ATPase. 34/76 Gene Ontology BP GO:0032781 0.861434063460992 0.924558103709983 4480 3297.81818181818 3361 0.164457065600363 1834 0.858982002181133 0.858982002181133 1 0.111073323202301 4480 2290 1834 2562 3358 1907 4603 3361 3707 4451 3723 3799 M11200 GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. 13/26 Gene Ontology BP GO:2000251 0.769054525565905 0.847950644075634 3365 3320.54545454545 3362 0.124739713930931 1626 0.342303550502489 -0.239540318996902 -1 0.0930700833119207 3362 2427 2494 3551 4317 1626 4573 4166 4266 3188 2556 3800 M15586 GO_PROTEIN_ACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACYLATION.html The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. 94/188 Gene Ontology BP GO:0043543 0.405554054356194 0.527595257600395 3435 3268.09090909091 3362 0.0461836540475117 976 1.26299627138321 1.47370605752984 1 1.33132411304028 3434 4358 3362 4488 4451 976 3317 4414 2788 2874 1487 3801 M11883 GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. 9/22 Gene Ontology BP GO:0035067 0.00420231153922008 0.022247813542302 855 2324.36363636364 3363 0.000421027949385409 98 0.22564685689763 0.270070325028261 1 1.41557822784496 851 3859 3820 3909 3780 207 98 976 4394 3363 311 3802 M15414 GO_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_INVAGINATION.html The infolding of a membrane, resulting in formation of a vesicle. 26/170 Gene Ontology BP GO:0010324 0.592644161094182 0.699452679196819 2700 3117 3363 0.0783986845409931 1390 1.06823553432498 -0.989745402399581 -1 0.629480867850753 2699 4550 2219 4136 3363 3574 1390 2693 3821 2473 3369 3803 M10662 GO_IRON_COORDINATION_ENTITY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_COORDINATION_ENTITY_TRANSPORT.html The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 4/13 Gene Ontology BP GO:1901678 0.849030415015817 0.915455969875182 2845 3270.18181818182 3366 0.17226952315193 2394 0.251018720676434 -0.0860107309500826 -1 0.0365528026898268 2845 3487 3616 3536 3088 2879 2394 3997 3696 3068 3366 3804 M11906 GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 21/53 Gene Ontology BP GO:0045744 0.00280334203511466 0.0165982806083369 4185 2837.81818181818 3366 0.000255174597190052 175 0.75454737894715 -0.650112755713168 -1 5.09798263539463 4182 1030 1012 2333 175 4487 4595 3838 2256 3366 3942 3805 M10606 GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 13/39 Gene Ontology BP GO:0061013 0.814574321122527 0.888226531933277 4250 3379.27272727273 3367 0.14203417546654 1925 1.35593454827845 1.35593454827845 1 0.264943292204295 4246 4370 2604 4260 2971 3097 3407 2290 3367 1925 4635 3806 M10337 GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-5 production. 7/42 Gene Ontology BP GO:0032674 0.875551636940408 0.935816355965542 3370 3277.18181818182 3369 0.188106772233921 2489 0.352193564114213 -0.417808251236076 -1 0.0385143333134555 3429 3369 3567 3005 3157 2489 4100 3370 3919 3004 2640 3807 M12035 GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. 11/36 Gene Ontology BP GO:0060706 0.514011397665828 0.627050688219243 4055 2998.54545454545 3371 0.0634920634920635 895 0.896585420808603 0.896585420808603 1 0.68983778236651 4055 895 2267 1141 3371 2282 4330 4089 2613 3399 4542 3808 M13902 GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of erythrocyte differentiation. 27/48 Gene Ontology BP GO:0045646 0.834367499525838 0.903233457752032 4280 3287.18181818182 3371 0.150793650793651 1913 0.849254971022537 0.849254971022537 1 0.142484438748211 4279 2625 1913 2696 3527 2412 4444 3696 3371 3868 3328 3809 M12375 GO_SYNAPTIC_VESICLE_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_ENDOCYTOSIS.html Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished. 12/27 Gene Ontology BP GO:0048488 0.639507643283071 0.736417159663516 2950 3340.54545454545 3372 0.0885815334156005 1957 0.305264336960085 0.320345279562875 1 0.153967895773342 2949 2894 3063 3372 4094 4237 4122 1957 3123 3472 3463 3810 M13951 GO_INTERSTRAND_CROSS_LINK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTRAND_CROSS_LINK_REPAIR.html Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. 25/49 Gene Ontology BP GO:0036297 0.843719304846805 0.911301005611437 2185 3254.90909090909 3373 0.155268543857021 1819 0.277882486190745 -0.280715816218268 -1 0.0425485130103697 2185 3681 3117 3897 3373 1819 3305 3787 3923 3887 2830 3811 M14705 GO_ACTIVATION_OF_MAPKKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKKK_ACTIVITY.html Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). 7/13 Gene Ontology BP GO:0000185 0.147859119791321 0.249186894080256 4080 3065.72727272727 3373 0.0158730158730159 1396 0.510466386151838 0.517236866000058 1 1.16932038808292 3653 1709 4275 2155 2397 3373 4613 1999 1396 4077 4076 3812 M10669 GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epidermis development. 39/90 Gene Ontology BP GO:0045682 0.2094880921561 0.318380756753117 3840 3249.27272727273 3374 0.021143685098328 1110 1.52111690612723 -1.33403223803043 -1 2.8699391525129 3838 2100 1110 2965 3830 4376 3374 4511 3330 2038 4270 3813 M10732 GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS.html The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. 13/43 Gene Ontology BP GO:0060441 0.834367499525838 0.903233457752032 2590 3289.09090909091 3374 0.150793650793651 2164 0.313643597294635 0.444238173560768 1 0.0526218077698378 2589 3891 2850 3549 4346 3657 2164 3584 3374 3084 3092 3814 M10607 GO_INTERMEDIATE_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_ORGANIZATION.html Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 12/32 Gene Ontology BP GO:0045109 0.336354459480255 0.457015824864192 1240 3103.90909090909 3375 0.0365872711171651 1238 0.472325574930843 -0.554285474250104 -1 0.609698929742256 3375 3758 1238 3993 3855 1238 2101 4622 4212 3058 2693 3815 M15118 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. 42/84 Gene Ontology BP GO:0045669 0.0839184282471183 0.158445571591463 4010 2869.81818181818 3375 0.00793650793650794 1118 1.71117180412693 -1.38945983718384 -1 5.19703827803789 4006 2960 1188 1681 3375 3941 3799 3992 1118 1279 4229 3816 M12346 GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. 61/127 Gene Ontology BP GO:0006892 0.047872408209489 0.118890959210725 4115 3038.18181818182 3377 0.00444972760284439 946 1.04023100199913 1.31962195245356 1 3.65181588839251 4113 3737 3377 3466 946 1814 3630 3623 2848 2798 3068 3817 M14290 GO_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. 17/63 Gene Ontology BP GO:0006939 0.027751559607699 0.0815509438345231 3755 3171.18181818182 3377 0.00255526701218307 704 0.56736595004827 -0.537046192773498 -1 2.3443759805299 3751 3249 704 3377 3754 1701 3716 4343 3280 3970 3038 3818 M16897 GO_FATTY_ACID_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_ELONGATION.html The elongation of a fatty acid chain by the sequential addition of two-carbon units. 7/13 Gene Ontology BP GO:0030497 0.544383758423646 0.656068916285646 4580 3465.45454545455 3377 0.0756000363716772 1813 0.331341771250457 0.197379648867899 1 0.230226032900708 4576 1813 4634 3102 2516 2779 4460 2717 3377 4624 3522 3819 M11946 GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. 6/11 Gene Ontology BP GO:0033262 0.509928781670859 0.626514774622334 2895 3346.36363636364 3378 0.0688365521287888 1291 0.234008964938967 0.18894563616117 1 0.180377630806548 2891 4352 3832 4326 4308 2595 1291 2380 4393 3378 3064 3820 M14420 GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION.html A cardiac conduction process that modulates the frequency or rate of heart contraction. 22/62 Gene Ontology BP GO:0086091 0.834367499525838 0.903233457752032 3765 3413.63636363636 3379 0.150793650793651 2248 1.42279293755586 -1.42279293755586 -1 0.238710234477585 3763 2635 2248 3120 4241 3558 4443 3176 3379 2362 4625 3821 M16164 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. 21/60 Gene Ontology BP GO:0002717 0.068297747046578 0.152671367255949 3820 3127.18181818182 3379 0.00641045447649233 1114 0.406506845496313 -0.320838202558986 -1 1.25948861973372 3820 1694 1890 2726 1114 4076 4339 3379 3823 4429 3109 3822 M11963 GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 9/20 Gene Ontology BP GO:0051974 0.941807655753277 0.985978116271131 3335 3595.54545454545 3380 0.247534512730791 2634 0.310467200906911 -0.261850741515955 -1 0.00722730484014995 3359 3999 3834 4157 3334 2634 3148 4020 4354 3380 3332 3823 M15907 GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. 36/93 Gene Ontology BP GO:0045071 0.466738071388703 0.580826820010117 4085 3215 3381 0.0555555555555556 2056 1.35593454827845 1.35593454827845 1 1.21442887054543 4084 3381 2056 4000 2806 3633 3569 2140 2551 2630 4515 3824 M16096 GO_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING.html The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 204/464 Gene Ontology BP GO:0008380 0.576931041116296 0.684561927907734 1525 3119.45454545455 3381 0.0752222368137122 1251 1.01231098973602 -0.590143302512388 -1 0.632437178371885 1525 4489 3502 4421 3699 1251 3381 3234 3854 2925 2033 3825 M11402 GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. 6/17 Gene Ontology BP GO:0045835 0.171126225722686 0.272029640537428 4540 3315.90909090909 3382 0.0185937037894123 1678 0.364704293808471 -0.148968406654716 -1 0.782692994464273 4536 3793 3738 3382 1678 3106 4567 1932 2808 3244 3691 3826 M13046 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 19/36 Gene Ontology BP GO:0006294 0.510917736857633 0.627050688219243 2625 3044.45454545455 3382 0.0629516676282334 1136 0.16497882581723 -0.19019971615792 -1 0.126935621044451 2625 4328 3432 3982 3382 1136 2563 2642 4081 3635 1683 3827 M13065 GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT.html Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. 7/19 Gene Ontology BP GO:2000641 0.498753288340192 0.615553300840912 3105 3268.45454545455 3382 0.066734624466495 1785 0.340315739515697 0.392176986391177 1 0.272222844982955 3105 3867 4005 2892 4052 3288 2444 1785 3491 3642 3382 3828 M14087 GO_RESPONSE_TO_VITAMIN_A http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_A.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. 7/32 Gene Ontology BP GO:0033189 0.0765897756730953 0.158445571591463 3385 2988.45454545455 3382 0.00793650793650794 886 0.611583897623015 -0.42301369869579 -1 1.85745517680824 3382 1874 4182 2072 4092 3595 2348 2490 886 3918 4034 3829 M14198 GO_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MIGRATION.html The movement of a T cell within or between different tissues and organs of the body. 6/27 Gene Ontology BP GO:0072678 0.111740373659326 0.199849982627215 2830 3074.72727272727 3382 0.0117791962946471 537 0.358939333803168 0.342390082222571 1 0.952772593465897 2826 3868 4202 3661 2741 3382 537 2236 3856 3943 2570 3830 M11977 GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS.html The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. 9/17 Gene Ontology BP GO:0016973 0.0375511182339957 0.100086017198876 2995 3114.63636363636 3384 0.00382011712488109 879 0.199022794273701 -0.204072487175576 -1 0.755175429682669 2992 3401 3837 4370 879 1803 1786 4505 4586 3384 2718 3831 M10446 GO_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 698/1714 Gene Ontology BP GO:0044248 0.0348460772683977 0.0955078729381172 3385 2838 3385 0.00354048614031463 204 1.17528652466486 1.41276835685832 1 4.55024184744424 3385 4382 3586 4365 1094 204 4204 3451 2889 2902 756 3832 M15301 GO_MITOCHONDRION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_MORPHOGENESIS.html The process in which the anatomical structures of a mitochondrion are generated and organized. 16/37 Gene Ontology BP GO:0070584 0.609428039962129 0.711842613721803 3195 3348.09090909091 3386 0.0819170656391373 1334 0.211236030017546 -0.215398617184748 -1 0.118361022964388 3195 4460 2964 4533 3386 1334 1936 4629 4537 4232 1623 3833 M15649 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING.html The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. 15/29 Gene Ontology BP GO:0000717 0.245151184878919 0.357936148236737 2110 2884 3386 0.0252430023637115 686 0.174675082847442 -0.20042839847225 -1 0.295843711769791 2108 4336 3386 4033 4084 686 1628 2206 3939 4324 994 3834 M12523 GO_L_ASCORBIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 9/12 Gene Ontology BP GO:0019852 0.441970387911988 0.560827688186761 3165 3293.72727272727 3387 0.0566654855768582 1946 0.88632027725861 0.88632027725861 1 0.845019319975652 3164 2978 3923 2939 2330 4479 3387 1946 3750 3511 3824 3835 M16827 GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 9/22 Gene Ontology BP GO:0071371 0.0765897756730953 0.158445571591463 3390 2979.54545454545 3388 0.00793650793650794 828 0.632207485932307 0.60041455362277 1 1.92009153957382 3388 1503 4622 2075 1570 3563 2374 4136 828 4602 4114 3836 M15393 GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-glutamate across a membrane. 5/13 Gene Ontology BP GO:0089711 0.099093929318164 0.180996504258157 3390 2972.81818181818 3389 0.0103811675195765 749 0.606521418004051 0.697463928642748 1 1.70903231829507 3389 749 4395 1856 1354 3479 4220 3704 2005 4256 3294 3837 M12364 GO_NEURAL_CREST_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_MIGRATION.html The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. 24/70 Gene Ontology BP GO:0001755 0.063745235880388 0.145654099504253 3055 3036.09090909091 3390 0.00597007654139723 829 1.1928936815878 1.1928936815878 1 3.78849701186116 3052 2778 829 2186 4267 4099 3424 4005 3390 1353 4014 3838 M14655 GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. 8/19 Gene Ontology BP GO:0006646 0.494032365611556 0.611026178352279 3905 3128.27272727273 3391 0.0658593446888504 1251 0.430241238532338 -0.269862363179816 -1 0.349390931351806 3905 1251 4267 2262 2606 3995 2468 1780 3391 4066 4420 3839 M15787 GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. 32/77 Gene Ontology BP GO:0000245 0.433522083253009 0.552750250917506 2225 3201.45454545455 3394 0.0503532430166512 1019 0.202314328873701 -0.212950154189585 -1 0.197725316870225 2223 4546 3394 4515 3434 1019 2574 3280 4248 4351 1632 3840 M16605 GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY.html Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex. 6/15 Gene Ontology BP GO:0051488 0.777898742017093 0.85627877173669 2715 3411.27272727273 3394 0.139689740905304 1728 0.228244167615116 -0.235151594736765 -1 0.0583806609682412 2715 3227 4590 3741 3394 1728 3866 2875 4592 4539 2257 3841 M11179 GO_BONE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 14/29 Gene Ontology BP GO:0098751 0.530566970997755 0.642687828422275 3495 3454.27272727273 3395 0.06643823061533 2433 0.212668259025949 -0.222128510168817 -1 0.154992600588475 3494 4145 3270 4039 2433 3078 3939 3395 3878 3183 3143 3842 M12791 GO_POLYOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSPORT.html The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/22 Gene Ontology BP GO:0015791 0.302070553863636 0.417118939692554 3060 3153.27272727273 3395 0.0353247146516677 1988 0.551182287778331 0.607515543539787 1 0.794490910977767 3057 1988 3961 2112 2056 3395 2896 3998 4142 3577 3504 3843 M10374 GO_REGULATION_OF_ICOSANOID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ICOSANOID_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. 12/42 Gene Ontology BP GO:0032303 0.557443745451391 0.666249592815201 4230 3559.18181818182 3396 0.0714285714285714 2191 0.349522922910404 -0.293286394266145 -1 0.233986326309771 4226 3396 2744 3090 4498 4412 4402 2191 2729 3010 4453 3844 M13411 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. 38/67 Gene Ontology BP GO:0032981 0.149217785798345 0.250950923337751 800 2612.63636363636 3396 0.0145834436245704 480 0.564322045552235 -0.564322045552235 -1 1.28612456690428 796 4394 3422 4280 3396 480 944 1979 4239 3733 1076 3845 M15064 GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. 38/67 Gene Ontology BP GO:0010257 0.149217785798345 0.250950923337751 800 2676.27272727273 3397 0.0145834436245704 481 0.564322045552235 -0.564322045552235 -1 1.28612456690428 797 4395 3423 4281 3397 481 945 2234 4240 4169 1077 3846 M12032 GO_NEGATIVE_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_AGING.html Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 14/27 Gene Ontology BP GO:0090344 0.796857884494719 0.871663543578164 2675 3221.63636363636 3398 0.134887226212261 1799 0.313547342927213 -0.267615194665714 -1 0.0709951922066334 2675 3888 2359 3758 3441 2876 1799 4546 4207 3398 2491 3847 M13145 GO_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other. 68/132 Gene Ontology BP GO:0007062 0.859511132712701 0.92270755819308 1560 3186.45454545455 3398 0.16340955315863 1558 1.73041933125535 1.73041933125535 1 0.229472579352021 1558 4218 2234 4113 3951 2109 3421 3398 4186 2826 3037 3848 M14518 GO_DNA_METHYLATION_OR_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_OR_DEMETHYLATION.html The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. 26/65 Gene Ontology BP GO:0044728 0.577473100938032 0.68503004794463 2960 3277.90909090909 3399 0.0753300157295083 1561 0.231762300636922 -0.220417764074215 -1 0.144531381401196 2957 3805 3352 3970 3399 1715 4049 3098 4117 4034 1561 3849 M12841 GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. 9/19 Gene Ontology BP GO:0007007 0.715252723608093 0.800961396746048 2790 3149.63636363636 3400 0.118045952048701 2108 0.18288057276413 -0.221092848699738 -1 0.0669113266608423 2790 3923 3967 3742 2827 2108 2188 3919 3400 3584 2198 3850 M13702 GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. 20/36 Gene Ontology BP GO:0000959 0.832474972421345 0.902855048937207 2095 3243.72727272727 3400 0.149916100552323 1899 0.193322553660199 -0.234039219230225 -1 0.0325683920449055 2094 4198 3248 4344 3400 1899 3660 2320 4385 3810 2323 3851 M11555 GO_REGULATION_OF_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of tolerance induction. 20/59 Gene Ontology BP GO:0002643 0.815580573003586 0.888471774882948 3510 3417.54545454545 3401 0.142458489881436 1764 0.328501678555569 -0.319604544341044 -1 0.0640381967985408 3510 3953 1764 4131 2990 3032 3912 3401 4328 3287 3285 3852 M14545 GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. 12/21 Gene Ontology BP GO:2000773 0.432331745160578 0.551612061769872 2250 2998.45454545455 3401 0.0501720079222847 1105 0.346178181325968 0.359479491188712 1 0.339502282013305 2249 3544 2045 3401 3603 2329 1105 4255 4206 4042 2204 3853 M10951 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html The directed movement of a protein to a specific location. 792/1849 Gene Ontology BP GO:0045184 0.0163939077600538 0.0575770905672691 3405 2802.72727272727 3402 0.00165161206922657 131 1.24397235809402 1.44789557747913 1 5.85399271655863 3402 3874 3662 3857 1427 131 4090 4097 2688 2773 829 3854 M14963 GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. 12/24 Gene Ontology BP GO:1903672 0.834367499525838 0.903233457752032 2915 3388.45454545455 3402 0.150793650793651 2456 0.360285252851099 0.408263070369003 1 0.0604471492152944 2912 3020 2456 2467 3402 3544 4194 4220 3356 4139 3563 3855 M10298 GO_REGULATION_OF_RNA_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_STABILITY.html Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. 92/186 Gene Ontology BP GO:0043487 0.790545492166456 0.866502058576217 3405 3368.18181818182 3403 0.13247722946704 1677 1.34373861851409 1.4346766736595 1 0.317412941971457 3401 4278 3403 4389 3001 1677 3903 3991 3487 2514 3006 3856 M12380 GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. 61/149 Gene Ontology BP GO:0002220 0.265976265180516 0.382330587997875 3405 3230.36363636364 3403 0.027718936046873 727 0.653874098340854 0.653874098340854 1 1.03638530781433 2941 4390 3401 4516 2930 727 3403 4113 4177 3473 1463 3857 M12048 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION.html The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. 15/30 Gene Ontology BP GO:0000715 0.656445499382335 0.752005046541373 1745 3035.18181818182 3404 0.0925602787670158 1369 0.141431902669379 -0.157047349143958 -1 0.0664511410935312 1743 4337 3417 4166 3826 1369 1963 2537 4536 3404 2089 3858 M10424 GO_RIBOSOME_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. 195/424 Gene Ontology BP GO:0042254 0.968540355767845 0.999999998379914 3355 3700.27272727273 3405 0.269816248935028 2925 0.493393016758395 -0.493393016758395 -1 1.14078256526069e-09 3351 4587 3510 4574 3391 2925 4290 3405 4411 3024 3235 3859 M14949 GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS.html The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. 19/37 Gene Ontology BP GO:0046716 0.597318307603006 0.701403364238937 4515 3320.72727272727 3406 0.0793650793650794 2070 0.380736129439928 -0.396781576897433 -1 0.222608997509803 4513 2070 2616 2606 4280 3144 3462 3406 2860 4135 3436 3860 M13062 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. 23/35 Gene Ontology BP GO:0000462 0.913195421952417 0.962821572801572 4620 3527.09090909091 3407 0.199237225810086 2179 0.123779361057815 -0.13740635562854 -1 0.0077309328552956 3167 4619 3407 4602 4237 2179 3109 2844 4618 3640 2376 3861 M15385 GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 15/49 Gene Ontology BP GO:0045923 0.434873646050734 0.553638151525516 2370 3226.72727272727 3407 0.0505594456005398 1616 0.649810243057386 -0.649810243057386 -1 0.63335151474782 2370 3570 2607 3138 2799 3925 4280 1616 3528 4254 3407 3862 M13221 GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. 21/44 Gene Ontology BP GO:0070911 0.288836405850602 0.407124296406905 2080 2953.45454545455 3408 0.0305114522064302 773 0.186621618527905 -0.215631498815242 -1 0.276463413437087 2078 4555 3408 4388 4368 773 1659 2289 4148 3675 1147 3863 M14271 GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION.html The modification of a protein by cis-trans isomerization of a proline residue. 15/41 Gene Ontology BP GO:0000413 0.850621352955467 0.915455969875182 3585 3333.54545454545 3408 0.158730158730159 2116 0.354339677445603 -0.2722214471665 -1 0.0515981768141614 3583 2116 2753 3408 3661 2212 4237 4217 3395 3966 3121 3864 M15332 GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 149/352 Gene Ontology BP GO:0010498 0.00793243747299498 0.0346092586912415 1315 2771.27272727273 3409 0.000723744028161858 77 0.525602276263726 -0.525602276263726 -1 2.91445610469097 1314 4118 3409 4299 4516 77 1506 2521 3959 4242 523 3865 M13536 GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. 26/46 Gene Ontology BP GO:0070830 0.0893146077804597 0.166290183948014 2130 2777.54545454545 3410 0.00846918581571604 349 0.34089666443769 -0.337948004781145 -1 1.00818863466342 2128 3807 2407 4259 4192 349 1554 3801 3410 3769 877 3866 M12097 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 12/35 Gene Ontology BP GO:0050650 0.8575571976805 0.920926520895594 2535 3433 3411 0.162358418478323 2353 0.358486688806981 0.45899936847908 1 0.0486810737829588 2534 3216 2353 4179 3051 4306 3764 3106 4195 3411 3648 3867 M12670 GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 70/262 Gene Ontology BP GO:0038095 0.61805455751227 0.719816051127585 3415 3321.45454545455 3411 0.0837792543704446 1308 0.900299882295612 0.900299882295612 1 0.487929591985926 3411 4159 3461 4547 2937 1308 4284 4171 3182 2830 2246 3868 M15081 GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION.html Any process that activates or increases the frequency, rate or extent of dendrite extension. 7/29 Gene Ontology BP GO:1903861 0.562604368603265 0.670992058418947 2705 3509 3411 0.0793650793650794 2688 0.40394779026931 0.463940659460563 1 0.265697503094085 2703 2688 4345 3261 2834 4321 3814 4208 2836 4178 3411 3869 M15443 GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 32/95 Gene Ontology BP GO:0051193 0.177821502460332 0.279493986433081 4135 3174.27272727273 3411 0.01764231549764 1354 0.385847122419596 -0.454215919433847 -1 0.810849356070932 4131 4091 2187 4150 1646 1354 3693 3411 3138 4272 2844 3870 M10384 GO_INTERMEDIATE_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. 25/72 Gene Ontology BP GO:0045103 0.747433230220826 0.828439362118714 3415 3431.45454545455 3412 0.117589708667871 1583 0.320942392140416 -0.389445577177611 -1 0.0995783885166434 3412 4456 2239 4491 4360 1583 3150 4425 4259 3014 2357 3871 M11789 GO_SEQUESTERING_OF_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUESTERING_OF_METAL_ION.html The process of binding or confining metal ions such that they are separated from other components of a biological system. 8/22 Gene Ontology BP GO:0051238 0.211805826884969 0.321167359316431 2150 2939.63636363636 3412 0.0235200688454313 1506 1.03069309216194 -1.03069309216194 -1 1.92983449984218 2149 4232 3805 4381 1809 1595 4032 3412 3782 1506 1633 3872 M13207 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS.html Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 19/38 Gene Ontology BP GO:0036003 0.850621352955467 0.915455969875182 4320 3191.27272727273 3412 0.158730158730159 1919 0.409240410619788 -0.354813335569418 -1 0.0595927027664448 4320 1940 1988 1919 3858 2716 4160 3229 3412 3672 3890 3873 M15666 GO_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_EXTENSION.html Any process that modulates the frequency, rate or extent of dendrite extension. 7/29 Gene Ontology BP GO:1903859 0.562604368603265 0.670992058418947 2705 3530.09090909091 3412 0.0793650793650794 2689 0.40394779026931 0.463940659460563 1 0.265697503094085 2704 2689 4436 3262 2835 4322 3815 4191 2837 4328 3412 3874 M14029 GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION.html The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. 48/108 Gene Ontology BP GO:0006369 0.834349914041269 0.903233457752032 2950 3363.90909090909 3414 0.150785454672469 1797 0.795460638453866 -0.635897419203641 -1 0.133459051137973 2948 4192 3440 4155 3228 1797 3041 3414 3961 3904 2923 3875 M15108 GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. 7/19 Gene Ontology BP GO:0002313 0.33296556889208 0.452829272514917 3415 3223.63636363636 3414 0.0396825396825397 1481 0.428397783844712 0.446601993458303 1 0.559494191426892 3414 3028 4354 3054 3581 4150 1481 2434 2199 4185 3580 3876 M16545 GO_RESPONSE_TO_HISTAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HISTAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. 4/19 Gene Ontology BP GO:0034776 0.0142868476318302 0.0526380793457477 1650 2773.09090909091 3414 0.00143795387458427 198 0.512913266451936 -0.512913266451936 -1 2.48954405946521 1647 3414 4577 3682 4619 496 198 2488 4434 4527 422 3877 M16611 GO_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. 10/43 Gene Ontology BP GO:0030224 0.769769344168745 0.848335880601824 4235 3462.81818181818 3414 0.124986342119313 1735 0.403644326617196 -0.278420385867661 -1 0.109445999092541 4232 3254 1735 3832 2869 3405 3885 2760 4162 4543 3414 3878 M11656 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL.html A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. 60/138 Gene Ontology BP GO:0070646 0.788313334227591 0.864873500594784 4200 3339.72727272727 3415 0.131640801091676 1674 1.41813868093395 1.41813868093395 1 0.339385418690184 4199 3561 3298 4240 2908 1674 4001 3775 3415 2509 3157 3879 M13346 GO_CARDIAC_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_FATE_COMMITMENT.html The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. 4/19 Gene Ontology BP GO:0060911 0.144184240802902 0.246029926515206 4060 3166 3415 0.0154494300123278 1097 1.07272638267715 -1.07272638267715 -1 2.47983101815302 3764 3229 4057 2599 1568 3010 3415 4549 4059 1097 3479 3880 M11466 GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING.html Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. 12/21 Gene Ontology BP GO:0000469 0.410339988666558 0.532776445016451 3420 3511.27272727273 3416 0.0468843361694773 2222 0.205882374104252 -0.178407874524438 -1 0.213703798731395 3416 4178 3008 3898 2222 2822 3971 4141 4416 3260 3292 3881 M11491 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. 5/21 Gene Ontology BP GO:0002674 0.407070145086198 0.529270983935933 3460 3346.54545454545 3416 0.0509254409520906 2269 0.47662475361191 0.434681171069982 1 0.499918437224092 3456 2797 3758 3109 2269 4370 2547 3416 3820 3269 4001 3882 M11719 GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 31/83 Gene Ontology BP GO:0030811 0.517759337492288 0.630794175800759 4570 3394.81818181818 3416 0.0641509528991813 1758 0.411422859800512 0.352167891764951 1 0.312514007299295 4567 4195 1758 4091 2409 1994 4484 3871 3233 3325 3416 3883 M11779 GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 17/63 Gene Ontology BP GO:0045979 0.850621352955467 0.915455969875182 3665 3290.27272727273 3416 0.158730158730159 1854 0.396690397622411 0.269457613729924 1 0.0577651970336762 3567 3662 2123 3664 4178 1854 2941 4518 3416 3341 2929 3884 M15006 GO_REGULATION_OF_TRANSLATIONAL_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_FIDELITY.html Any process that modulates the ability of the translational apparatus to interpret the genetic code. 12/16 Gene Ontology BP GO:0006450 0.847578959881005 0.914337618663454 2925 3466.18181818182 3416 0.157186746418499 2367 0.168359971062105 -0.167625515786297 -1 0.0248554774927505 2923 3851 3416 4074 3025 2367 4012 3356 3984 4155 2965 3885 M16203 GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 14/38 Gene Ontology BP GO:0071549 0.0231298127291375 0.0728079461026343 4470 3016.27272727273 3416 0.00212514816616748 679 0.553705961887482 -0.489355400895519 -1 2.39144534476826 4466 1907 679 2042 1144 3413 3416 3894 3640 4442 4136 3886 M14516 GO_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPOLYMERIZATION.html The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. 21/40 Gene Ontology BP GO:0051261 0.433965503330083 0.552981645148707 2810 3210.27272727273 3417 0.0504208445187459 1020 0.273646418183611 -0.264649539327575 -1 0.267250604826479 2806 4404 2128 4392 4246 1020 3417 2700 4476 4033 1691 3887 M12129 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition. 11/30 Gene Ontology BP GO:1902751 0.0420210262708699 0.1086323078929 4375 3224.63636363636 3418 0.00389507166548496 639 0.290803818009798 -0.272861678988842 -1 1.06414996942251 4375 3066 2617 3541 3129 3818 2538 639 4170 3418 4160 3888 M15991 GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of autophagosome assembly. 24/43 Gene Ontology BP GO:2000785 0.63389956273523 0.731410454716618 3420 3413.81818181818 3418 0.0873015873015873 1861 0.610681132932434 0.610681132932434 1 0.314880441372151 3418 3501 3301 3936 4456 1861 3659 3258 2996 4397 2769 3889 M12231 GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that modulates the frequency, rate, or extent of immunoglobulin production. 34/86 Gene Ontology BP GO:0002637 0.273922212306907 0.392295136255697 3420 3218.72727272727 3419 0.0286805066965596 1916 0.343110421525804 0.384098241269539 1 0.529274570749166 2737 3419 2499 3746 1916 4024 3012 3154 3420 3440 4039 3890 M11876 GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 14/42 Gene Ontology BP GO:0060079 0.597318307603006 0.701403364238937 4020 3452.36363636364 3420 0.0793650793650794 2015 1.09257959149497 -1.3261771808088 -1 0.638810002208342 4017 3015 2244 3237 3539 4516 4499 3420 2866 2015 4608 3891 M14056 GO_BLASTODERM_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTODERM_SEGMENTATION.html The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. 8/27 Gene Ontology BP GO:0007350 0.00316662070609662 0.0181066748009934 4315 2893.90909090909 3422 0.000317114214561304 199 1.2692844111372 -1.07272638267715 -1 8.3937211844315 4314 1249 4177 1874 199 4620 3422 4641 2477 622 4238 3892 M16150 GO_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION.html Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. 42/127 Gene Ontology BP GO:0061337 0.466738071388703 0.580826820010117 2185 3192.45454545455 3423 0.0555555555555556 1280 1.3172927667316 -1.28127221255727 -1 1.17981975524099 3423 2345 2183 2185 4353 3646 4152 4329 2592 1280 4629 3893 M16331 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. 272/624 Gene Ontology BP GO:0045786 0.0842382143498372 0.15885981941382 3715 3232 3423 0.00796799565128083 1223 1.31388950476962 1.4163780034955 1 3.98478789212754 3713 4356 2653 4034 1223 2589 4184 3423 2881 2504 3992 3894 M13051 GO_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that modulates the frequency, rate or extent of a response to a food stimulus. 10/22 Gene Ontology BP GO:0032095 0.493477074739477 0.610664727616042 2370 3344 3425 0.0599620790630242 2366 0.319406762170852 0.442644151861047 1 0.259695876803176 2366 3297 2937 4013 2372 3425 3769 4159 3987 3637 2822 3895 M11879 GO_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 21/48 Gene Ontology BP GO:0032069 0.970093680386509 0.999999998379914 4285 3719.63636363636 3426 0.273169744374192 2992 0.22842916070456 -0.217859904501599 -1 4.33136128284712e-10 4285 4295 3137 4047 3398 2992 2997 4523 4454 3362 3426 3896 M12156 GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication. 4/13 Gene Ontology BP GO:2000105 0.838094675816583 0.906634105269431 2895 3427.72727272727 3426 0.166460638308105 2209 0.272549942359206 -0.352220836223129 -1 0.0440388569767918 2893 4116 3858 3659 4233 2408 3051 3332 4520 3426 2209 3897 M12154 GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. 10/32 Gene Ontology BP GO:0048026 0.758882382949317 0.838327600293523 3240 3546.36363636364 3427 0.121303301166223 1609 0.166876408024909 -0.17049259255521 -1 0.0485124149509166 3236 4628 2823 4464 4322 1609 3427 3828 4635 3425 2613 3898 M13947 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. 18/38 Gene Ontology BP GO:0070229 0.714763366747069 0.80083163894948 2840 3190.09090909091 3430 0.107777421533385 1618 0.35602692044461 0.348874008545448 1 0.130356238617217 2840 4038 2043 3710 3430 2517 1618 3742 3986 3885 3282 3899 M15952 GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT.html The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. 6/23 Gene Ontology BP GO:0060841 0.386086746459241 0.506813899861537 4125 3455.18181818182 3431 0.0476190476190476 2331 0.349257420448292 -0.218327837405129 -1 0.391289182959426 4124 2584 4486 3048 2774 3587 4179 3074 2331 4389 3431 3900 M14384 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that increases the amount of sodium excreted in urine over a unit of time. 5/17 Gene Ontology BP GO:0035815 0.618114709421857 0.719816051127585 4000 3437 3432 0.0917753328378922 1972 0.537496590811304 0.571484671629839 1 0.291303483807499 2580 2546 4232 3432 4490 3427 3780 1972 3996 3996 3356 3901 M11133 GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 8/125 Gene Ontology BP GO:0048385 0.692053852342561 0.781181267212663 4440 3619.72727272727 3433 0.111111111111111 3132 0.378429022142517 -0.242316401411226 -1 0.154057056503988 4440 3301 3698 3270 3433 4095 3132 4028 3174 3176 4070 3902 M11859 GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 16/35 Gene Ontology BP GO:0090200 0.96033296341709 0.998002665922198 4510 3563.27272727273 3433 0.254265005525626 2320 0.289194749752412 -0.235567008126485 -1 0.000953161857133809 4508 2850 2804 3600 4345 2320 3099 4568 4313 3356 3433 3903 M12235 GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. 13/19 Gene Ontology BP GO:0031065 0.89558465899994 0.949794328857177 3985 3300.72727272727 3433 0.185676898298463 1936 1.10159638197239 1.10159638197239 1 0.0935414337239916 3982 3433 2207 3603 3150 2985 3826 4153 3918 1936 3115 3904 M13599 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate, or extent of mast cell activation. 8/21 Gene Ontology BP GO:0033005 0.179962304206945 0.282467471026791 2040 2890.63636363636 3435 0.0196449695263589 1709 0.260559899250787 0.276738347092677 1 0.543015363202066 2039 3692 4101 3678 1709 1821 2012 3435 3469 3784 2057 3905 M12204 GO_CITRULLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CITRULLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. 3/13 Gene Ontology BP GO:0000052 0.505517695709557 0.622049298346421 2620 3327.18181818182 3436 0.0680017960227495 1285 0.284112508523497 0.387767562741811 1 0.222348395750581 2620 4379 3869 4318 4524 2583 1285 2982 3890 3436 2713 3906 M13735 GO_POSITIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPAIR.html Any process that activates or increases the frequency, rate or extent of DNA repair. 27/61 Gene Ontology BP GO:0045739 0.128126392839965 0.22305618371052 3895 3333.72727272727 3436 0.0123872576219379 1444 1.21455215107271 1.21455215107271 1 3.00396566694925 3895 3143 2787 3436 1444 4445 3042 4032 3514 2496 4437 3907 M16145 GO_PROTEIN_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALKYLATION.html The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 60/135 Gene Ontology BP GO:0008213 0.00220220997342434 0.0139826785130856 1130 2558.72727272727 3437 0.000200401589985342 72 0.241200595443336 -0.272804199686783 -1 1.69781857220071 1130 4281 3437 4498 3557 86 1444 1346 3869 4426 72 3908 M10779 GO_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. 8/21 Gene Ontology BP GO:0043501 0.33296556889208 0.452829272514917 4505 3263.45454545455 3440 0.0396825396825397 1868 0.832372946379794 -1.09384222310118 -1 1.08709205844228 4505 1868 3632 2116 3390 3510 4292 3440 2179 3090 3876 3909 M13416 GO_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_URINE_VOLUME.html Any process that modulates the amount of urine excreted from the body over a unit of time. 14/30 Gene Ontology BP GO:0035809 0.195232560754943 0.302016917255021 3440 3063.36363636364 3440 0.0195519626135473 1092 0.825943122663656 -0.792904243146179 -1 1.63017638951125 3440 1856 1092 2152 1842 4512 4119 2774 3916 3735 4259 3910 M16608 GO_POSITIVE_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELINATION.html Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 8/16 Gene Ontology BP GO:0031643 0.67376573907556 0.764677175880671 1835 3315 3440 0.105968220041667 1604 0.325283965309856 0.454334882763404 1 0.143872351193431 1833 3440 4591 3088 4021 4571 1604 2544 3686 4541 2546 3911 M16609 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_SNRNP_ASSEMBLY.html The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. 23/45 Gene Ontology BP GO:0000387 0.895057053490257 0.949451656238351 2190 3453.18181818182 3443 0.185303687972254 2090 0.141355343317297 -0.17857667477013 -1 0.0120871964748521 2186 4616 3443 4560 3753 2090 2983 2497 4517 4542 2798 3912 M14293 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. 20/60 Gene Ontology BP GO:0032753 0.404403802860868 0.526246316334924 3225 3305.45454545455 3444 0.0460160166794818 1838 0.355625955063577 -0.328233424724975 -1 0.376366081809372 3221 3779 1838 4243 2207 2767 3811 3444 3883 3972 3195 3913 M15358 GO_RESPONSE_TO_X_RAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_X_RAY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). 20/37 Gene Ontology BP GO:0010165 0.0839184282471183 0.158445571591463 3445 2771.36363636364 3444 0.00793650793650794 874 1.7026876054589 1.7026876054589 1 5.17127072791148 3444 3470 1699 2353 4070 4174 3589 1857 874 1154 3801 3914 M11643 GO_PEPTIDYL_CYSTEINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_CYSTEINE_MODIFICATION.html The modification of peptidyl-cysteine. 11/37 Gene Ontology BP GO:0018198 0.646881139767778 0.742881308914616 3450 3301.45454545455 3447 0.0902922359660124 1962 0.366099027712441 -0.322300274062237 -1 0.179376966608488 3447 4071 2758 4123 2635 1982 4030 3995 4008 3305 1962 3915 M12254 GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 15/26 Gene Ontology BP GO:0050860 0.639389435323237 0.736417159663516 3040 3340.90909090909 3449 0.088554368330054 1476 0.368465414760994 0.391606706415658 1 0.185844979967649 3036 4020 1629 4248 4565 3971 1476 3184 3219 3449 3953 3916 M12877 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS.html The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. 68/130 Gene Ontology BP GO:0090501 0.815877141468416 0.888471774882948 3450 3470.18181818182 3449 0.142583947901593 1752 1.15547920299127 1.15547920299127 1 0.225249396196255 3449 4189 3289 4329 4058 1752 4149 3877 3348 2825 2907 3917 M12071 GO_HOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. 5/13 Gene Ontology BP GO:0050667 0.804956120936968 0.878564003175915 3040 3552.18181818182 3450 0.150793650793651 2298 0.213498582797582 0.332914497863608 1 0.0455663255007167 3040 4524 3847 4578 4212 3450 2298 2650 3364 3408 3703 3918 M14625 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION.html A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. 26/47 Gene Ontology BP GO:0033683 0.866697663357995 0.928919033003502 3000 3529 3450 0.167393500874629 1904 0.160740240069764 -0.188128125013781 -1 0.0195380930047296 2996 4552 3450 4511 4093 1904 3263 3128 4445 4060 2417 3919 M10864 GO_MATURATION_OF_SSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. 29/44 Gene Ontology BP GO:0030490 0.969588684295101 0.999999998379914 3250 3636.27272727273 3452 0.272062471238695 2399 0.124734693575464 -0.134417881261731 -1 1.56196392839746e-10 3249 4613 3452 4605 4145 2399 3636 3299 4626 3106 2869 3920 M12266 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. 4/13 Gene Ontology BP GO:0043371 0.44850862347306 0.568024695785855 2030 2957.45454545455 3452 0.0577766284057876 1187 0.252607975797844 0.252607975797844 1 0.235526954771371 2026 3928 3879 3944 4056 1725 1187 1951 4449 3452 1935 3921 M14258 GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. 24/50 Gene Ontology BP GO:1901532 0.1319037544912 0.228433096644029 4555 3052.09090909091 3452 0.01277700734212 983 0.555028496653813 -0.51290454810692 -1 1.35096400206548 4554 1691 983 1953 2844 3452 3587 4233 2638 3960 3678 3922 M14438 GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of B cell proliferation. 13/36 Gene Ontology BP GO:0030889 0.597318307603006 0.701403364238937 4600 3442.54545454545 3452 0.0793650793650794 2356 0.375457379609564 0.315022631761495 1 0.219522615320372 4598 2356 2434 3104 4543 3979 3452 2835 2899 4015 3653 3923 M12055 GO_NUCLEAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSPORT.html The directed movement of substances into, out of, or within the nucleus. 218/481 Gene Ontology BP GO:0051169 0.782823849318633 0.860272457369565 3455 3450.09090909091 3453 0.12961741326652 1807 0.926651780148408 0.926651780148408 1 0.229912345680127 4109 4275 3453 4477 2897 1807 4326 3658 3452 2913 2584 3924 M14283 GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. 12/40 Gene Ontology BP GO:0042537 0.062799588549917 0.143776375560781 4365 3372.27272727273 3453 0.00587884550076012 825 0.468171293427563 -0.415589068489143 -1 1.49687398768007 4362 3253 825 3453 2093 2715 4535 3357 4134 3967 4401 3925 M14393 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 26/56 Gene Ontology BP GO:0032206 0.830797856930516 0.901260385450558 3455 3407 3453 0.149145934875219 2029 0.289139607972073 -0.27970981455073 -1 0.0495529891398101 3528 4291 2828 4152 2994 2029 3983 3453 3453 3998 2768 3926 M12188 GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 9/21 Gene Ontology BP GO:0010893 0.214139132665174 0.322775948981753 4065 3030.90909090909 3455 0.0238095238095238 1186 1.38916827744188 -1.38916827744188 -1 2.58958988974178 4062 1186 3866 1602 4379 3784 3455 3327 1754 1595 4330 3927 M13530 GO_PHAGOSOME_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_ACIDIFICATION.html Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. 16/30 Gene Ontology BP GO:0090383 0.850621352955467 0.915455969875182 3455 3592.09090909091 3455 0.158730158730159 2566 0.871631227212653 -0.801505046067566 -1 0.126925052803026 4426 3472 2566 3451 3321 4464 2791 4391 3411 3765 3455 3928 M15602 GO_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINESIS.html The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. 48/118 Gene Ontology BP GO:0000910 0.0211088327695053 0.0681645940254237 3460 3043.09090909091 3457 0.00193764850461542 600 1.07238417973978 1.07238417973978 1 4.74810660253375 4303 3457 1421 3456 600 2446 4167 4003 3543 2273 3805 3929 M12563 GO_RNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. 61/121 Gene Ontology BP GO:0009451 0.542472198907421 0.654720208423676 1715 3114.54545454545 3459 0.068615807918982 1186 0.738664740866751 -0.738664740866751 -1 0.515751887607361 1714 4445 3459 4361 3870 1186 3108 2324 4436 3525 1832 3930 M15465 GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 12/29 Gene Ontology BP GO:0032075 0.227662006694685 0.340429854133148 3460 3053.90909090909 3459 0.0232111968668924 668 0.245487040504347 -0.268209431072253 -1 0.436069794611766 3459 3959 2958 3717 2996 668 3594 2723 4370 4283 866 3931 M11199 GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX.html The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. 5/18 Gene Ontology BP GO:0021819 0.853233160620055 0.917240464172011 3545 3371.18181818182 3460 0.174603174603175 2388 0.287016194994218 0.265120375128605 1 0.0408732674504183 3541 3486 3706 2891 4437 3803 2388 2913 3460 3187 3271 3932 M13140 GO_CHEMOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of chemicals. 6/29 Gene Ontology BP GO:0007635 0.5423599579831 0.654720208423676 2880 3376.36363636364 3460 0.0751902458699823 1362 0.279688855406499 0.264752381810406 1 0.195284879671083 2878 3264 4018 3908 4155 3445 1362 2894 4098 3658 3460 3933 M12451 GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. 6/12 Gene Ontology BP GO:0009396 0.806295821299979 0.879819388553655 2375 3183.09090909091 3462 0.151378757036793 1802 0.307484859472186 -0.424703815455634 -1 0.0649017347987894 2374 3580 3909 3941 4540 1802 2260 3224 3462 3491 2431 3934 M12489 GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS.html The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. 18/42 Gene Ontology BP GO:0006904 0.462216543516742 0.580826820010117 3465 3231.36363636364 3463 0.0548303513217228 1664 0.481449101090274 -0.481449101090274 -1 0.431204949125153 3463 4298 3339 4151 3865 1712 3091 1664 4019 3502 2441 3935 M15735 GO_COLLECTING_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLECTING_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. 5/27 Gene Ontology BP GO:0072044 0.0765897756730953 0.158445571591463 3965 2743.27272727273 3463 0.00793650793650794 162 0.792904243146179 -0.792904243146179 -1 2.40814726630524 3963 162 4450 1394 3829 3463 3940 1933 420 4341 2281 3936 M15886 GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. 9/26 Gene Ontology BP GO:0042762 0.378492815965169 0.499812896622947 2605 3307.81818181818 3463 0.0464474864002592 1569 0.396702835838666 0.474686005765548 1 0.453541205235174 2602 2902 4474 3463 3612 4551 2100 1569 3649 4371 3093 3937 M16373 GO_TRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_PROCESSING.html The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. 67/118 Gene Ontology BP GO:0008033 0.298735036746822 0.413174493778819 2010 3092.09090909091 3463 0.0317460317460317 1828 1.10127572444747 -0.687595811501009 -1 1.60466176988152 2010 4279 3463 3952 3915 1828 3624 3636 2068 2823 2415 3938 M10348 GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 4/15 Gene Ontology BP GO:0035589 0.943052033313144 0.986193216998283 3045 3481.72727272727 3464 0.249159271787483 2413 0.330507977268644 -0.262922539559663 -1 0.00757497971800741 3044 4213 3570 3999 3653 3301 2413 3464 4300 3006 3336 3939 M10088 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR.html Any process that modulates the frequency, rate or extent of double-strand break repair. 17/48 Gene Ontology BP GO:2000779 0.6626972697617 0.758360461288678 4540 3497.72727272727 3465 0.094074020489157 2670 0.299675907577598 0.284404164408151 1 0.136643819981042 4537 2928 2896 2840 2670 3677 4478 3465 3997 2952 4035 3940 M15413 GO_NUCLEAR_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXPORT.html The directed movement of substances out of the nucleus. 106/222 Gene Ontology BP GO:0051168 0.551434593309426 0.663134690230392 1940 3200.54545454545 3465 0.0702893669667897 1197 0.211531003402432 -0.224642476891799 -1 0.143242488047555 1937 4494 3465 4568 3564 1197 2446 2722 4378 4264 2171 3941 M10079 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. 24/56 Gene Ontology BP GO:1903573 0.471560484529178 0.585885825439918 4140 3419.54545454545 3466 0.05633520504759 2030 0.522536967759313 0.522536967759313 1 0.460534498450447 4139 3466 3105 3969 2328 3256 2030 3981 4126 2949 4266 3942 M12744 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION.html Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. 82/173 Gene Ontology BP GO:0071166 0.873073102139874 0.934416597106681 3185 3578.36363636364 3466 0.171094772142746 1923 0.191568027303427 -0.190143960170112 -1 0.021421751682844 3182 4602 3466 4606 3796 1923 3383 3390 4480 3564 2970 3943 M11982 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 27/45 Gene Ontology BP GO:0071353 0.472176244395185 0.586493927963307 4620 3471.36363636364 3467 0.0564352214658164 1682 0.265760131556669 -0.294293142227464 -1 0.233771447728268 4619 4257 2457 4357 3467 4042 2303 1682 4395 3385 3221 3944 M14569 GO_REGULATION_OF_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_ORGANIZATION.html Any process that modulates the frequency, rate or extent of chromatin organization. 88/225 Gene Ontology BP GO:1902275 0.226234027188471 0.338621724125104 3890 3342.36363636364 3467 0.0230471538104246 1796 1.12130475341984 -1.13115893914357 -1 2.00166866452562 3889 4537 2885 4520 1796 3467 2774 2720 3659 2732 3787 3945 M12341 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 13/19 Gene Ontology BP GO:0033160 0.465830132961439 0.580826820010117 2555 3390.36363636364 3468 0.0554094846651993 2280 0.284503417332616 -0.268943702940404 -1 0.254812567484664 4225 3892 2280 3917 2317 2554 2551 4467 4383 3468 3240 3946 M12756 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. 7/28 Gene Ontology BP GO:0032693 0.910330139360585 0.961365068017397 3400 3361.72727272727 3469 0.214285714285714 1948 0.59760029566935 0.594416851115521 1 0.0388159513820541 3398 1948 3955 2396 3469 4420 3079 3233 3632 3568 3881 3947 M14287 GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. 245/631 Gene Ontology BP GO:1901361 0.750011788004272 0.830900675663049 3705 3498.90909090909 3469 0.118412524067332 2686 1.23340158055207 1.55847328518681 1 0.37665399047066 3704 4584 3469 4600 2830 2686 3050 3619 3232 2848 3866 3948 M14750 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. 17/30 Gene Ontology BP GO:1904376 0.0521167759662745 0.126425387048805 4305 3226.63636363636 3469 0.00485399616404809 982 0.365022361416218 -0.275859438294301 -1 1.24446638767567 4301 3325 2084 3469 982 2658 3717 4133 3208 4089 3527 3949 M12352 GO_CENTRIOLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE_ASSEMBLY.html A cellular process that results in the assembly of one or more centrioles. 9/27 Gene Ontology BP GO:0098534 0.59398190548727 0.700497329737718 1985 3103.81818181818 3470 0.0861928772739353 1327 0.263811594481175 -0.279747569002192 -1 0.15480763777307 1985 4230 3894 4120 3996 1327 1684 3314 4346 3470 1776 3950 M15974 GO_MACROMOLECULE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_METHYLATION.html The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. 102/226 Gene Ontology BP GO:0043414 0.103558357199638 0.187967729662987 1900 2969.36363636364 3470 0.00988914872747684 495 0.217772978812341 -0.236391555156072 -1 0.600064608013781 1896 4493 3470 4474 3813 495 2918 1831 4293 4393 587 3951 M16531 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. 17/30 Gene Ontology BP GO:1903077 0.0521167759662745 0.126425387048805 4305 3266 3470 0.00485399616404809 983 0.365022361416218 -0.275859438294301 -1 1.24446638767567 4302 3326 2085 3470 983 2659 3718 4123 3209 4523 3528 3952 M14841 GO_MUSCLE_FIBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FIBER_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. 20/79 Gene Ontology BP GO:0048747 0.043413714990479 0.111241654912138 4310 3232.09090909091 3472 0.00402680559320044 759 2.07333958077616 -2.07333958077616 -1 7.50592600380546 4308 3285 759 3472 3759 3503 4263 2859 2634 2298 4413 3953 M15953 GO_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXECUTION_PHASE_OF_APOPTOSIS.html A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. 32/76 Gene Ontology BP GO:0097194 0.173738956101625 0.274334942544153 3590 3224.09090909091 3472 0.0171998659753582 1504 0.322400886840373 -0.322729854752193 -1 0.687420491163871 3589 3382 2641 3947 1625 1504 4226 3472 4169 4390 2520 3954 M11652 GO_BONE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_GROWTH.html The increase in size or mass of a bone that contributes to the shaping of that bone. 6/26 Gene Ontology BP GO:0098868 0.879136193892288 0.937274247587117 4435 3566.72727272727 3473 0.19047619047619 2579 0.340311262224906 -0.396766077514881 -1 0.0363416353358245 4431 3408 3783 3473 3468 2932 2579 4318 3552 3307 3983 3955 M12606 GO_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR.html The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 285/574 Gene Ontology BP GO:0006281 0.287603791831339 0.406250199413723 635 2980.54545454545 3473 0.0303588131491372 631 0.650766069907627 -0.643179695930235 -1 0.96635811419102 631 4486 3473 4422 4440 1087 2400 2281 4321 3536 1709 3956 M13431 GO_METHIONINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 8/16 Gene Ontology BP GO:0009086 0.838494417110154 0.906855247762042 2615 3462.81818181818 3473 0.166666666666667 2499 0.296693497334671 -0.421853740633777 -1 0.047820708371875 2615 3897 4075 4065 4066 2499 3473 3081 3433 3739 3148 3957 M13471 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. 17/54 Gene Ontology BP GO:0046641 0.762786909831234 0.842440442993915 3100 3247.72727272727 3473 0.122606479528975 1888 0.351554972924512 -0.296458139184319 -1 0.0993637854001408 3097 3473 1888 3592 2856 2696 3656 3624 3877 3749 3217 3958 M16901 GO_FLUID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLUID_TRANSPORT.html The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 16/31 Gene Ontology BP GO:0042044 0.0889128899400018 0.165725631469863 2540 3180.72727272727 3474 0.00842943196378021 887 0.391371705871854 0.402261438869429 1 1.15966071038335 2538 3474 887 3567 2659 3057 2732 3551 4309 4627 3587 3959 M11445 GO_HIPPO_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPO_SIGNALING.html The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. 13/37 Gene Ontology BP GO:0035329 0.977692221556998 0.999999998379914 3535 3487.09090909091 3475 0.292282938390844 2577 0.262706283183648 -0.282369571797287 -1 5.24681005210066e-10 3531 3605 2852 3787 3475 3349 2577 3331 4371 3252 4228 3960 M12577 GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. 14/40 Gene Ontology BP GO:0000027 0.789847769450414 0.866087942135837 3475 3497.54545454545 3475 0.132214913544002 2854 0.221113578722095 -0.225431922410674 -1 0.0524048738943455 4208 2854 3338 3545 2914 3472 4621 2943 3475 3528 3575 3961 M14653 GO_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ORGANELLE.html A process in which a protein is transported to, or maintained in, a location within an organelle. 334/807 Gene Ontology BP GO:0033365 0.344592421927457 0.466727717330567 4530 3233.18181818182 3475 0.0376806389810925 879 1.26242058568076 1.39122051096901 1 1.58582714080257 4528 3875 3475 3763 2565 879 4393 4389 2793 2748 2157 3962 M15079 GO_PROTEIN_K63_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. 23/59 Gene Ontology BP GO:0070534 0.61289845370023 0.714996864454816 2265 3417.63636363636 3475 0.0826616773825856 1431 0.681111565817195 0.681111565817195 1 0.376680124586406 2261 4326 3131 4265 3344 3927 1431 2991 4267 4176 3475 3963 M15934 GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION.html The directed movement of the mitochondrion to a specific location. 14/23 Gene Ontology BP GO:0051654 0.466738071388703 0.580826820010117 4210 3539.54545454545 3475 0.0555555555555556 2453 0.333842333118391 0.279915597422564 1 0.299002461352668 3426 3475 2998 2453 4209 4602 4047 2626 2509 4384 4206 3964 M16038 GO_PEPTIDYL_ARGININE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_METHYLATION.html The addition of a methyl group to an arginine residue in a protein. 8/14 Gene Ontology BP GO:0018216 0.599197457358792 0.70254388750426 3340 3446 3475 0.0873735598088551 2433 0.187762250188877 -0.157624453173555 -1 0.109278027778883 3340 2981 4498 3489 2623 2433 3626 3475 4012 4404 3025 3965 M16573 GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. 9/31 Gene Ontology BP GO:0032331 0.117128812920782 0.207965230742329 1975 2860.90909090909 3476 0.0123803223585039 545 0.264624862788953 0.292906044681128 1 0.685059278884446 1971 3761 4584 3695 2545 1472 545 3773 3476 4535 1113 3966 M12390 GO_REGULATION_OF_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEEDING_BEHAVIOR.html Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. 4/30 Gene Ontology BP GO:0060259 0.692053852342561 0.781181267212663 4580 3817.18181818182 3477 0.111111111111111 3143 0.349019614207321 -0.443239255950062 -1 0.142084595196518 4578 3412 3901 3426 4513 3252 3350 4624 3143 3477 4313 3967 M10908 GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE.html The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. 8/15 Gene Ontology BP GO:0016254 0.785349360080989 0.862349906206979 3955 3498.45454545455 3478 0.142620256256938 2313 0.147749291948872 -0.107635718640151 -1 0.0360707275230682 3952 4267 3657 4087 2960 3312 3478 2313 4094 3117 3246 3968 M11464 GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. 5/20 Gene Ontology BP GO:0007216 0.69896235207 0.785972923386052 3480 3278.90909090909 3478 0.11312567714627 1954 0.284322284786606 -0.411769903826441 -1 0.112880343387723 3478 4156 3751 4254 4187 1954 3139 2113 3694 3259 2083 3969 M11281 GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. 27/77 Gene Ontology BP GO:1903313 0.608795239631 0.71128241006712 3995 3436.72727272727 3479 0.0817819407838337 1295 1.35593454827845 1.35593454827845 1 0.76152507429053 3992 4553 2921 4408 3201 1295 3479 4350 4154 2490 2961 3970 M13579 GO_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR.html A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). 66/133 Gene Ontology BP GO:0006289 0.884405132951484 0.941594366497074 4605 3519 3480 0.178112083508859 1962 0.194240141525667 -0.211285046230781 -1 0.0192702701114745 2728 4605 3480 4603 4012 1962 3115 3375 4506 3778 2545 3971 M12049 GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of endothelial cell development. 7/14 Gene Ontology BP GO:1901550 0.637087681083182 0.734906361060675 4505 3281.45454545455 3481 0.0963917840424446 1402 1.54796415353554 -1.54796415353554 -1 0.785996013329754 4501 3481 3843 2941 3218 3692 3828 1998 3199 1402 3993 3972 M12757 GO_PHAGOSOME_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_MATURATION.html A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. 29/49 Gene Ontology BP GO:0090382 0.63389956273523 0.731410454716618 3570 3285.63636363636 3481 0.0873015873015873 2356 0.871631227212653 -0.801505046067566 -1 0.449431971586729 3508 3881 2530 3069 3569 2597 4615 3481 2967 3569 2356 3973 M14578 GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. 7/14 Gene Ontology BP GO:1903140 0.637368823011256 0.735048048991869 4505 3321 3482 0.096461809430734 1419 1.54796415353554 -1.54796415353554 -1 0.785504074127591 4502 3482 4251 2942 3219 3693 3829 2000 3200 1419 3994 3974 M12418 GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of mast cell degranulation. 6/16 Gene Ontology BP GO:0043306 0.829154703133627 0.899898383976024 2345 3393.54545454545 3483 0.161968578068936 2082 0.181007819685403 0.19896788035793 1 0.0314725506650754 2341 4478 3905 4489 3125 2612 2082 4248 4376 3483 2190 3975 M12503 GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 4/107 Gene Ontology BP GO:0048387 0.287037369078193 0.405573495018275 1870 2860.45454545455 3483 0.033266703946435 1065 0.263960421091054 -0.263960421091054 -1 0.392694693426776 1866 3517 3919 3483 4387 1075 1869 2494 4285 3505 1065 3976 M12685 GO_PROTEIN_K11_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K11_LINKED_UBIQUITINATION.html A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. 17/35 Gene Ontology BP GO:0070979 0.340676223768335 0.461827651666097 2660 3233.72727272727 3483 0.0371593205663201 870 0.23217596101025 -0.229734081984154 -1 0.29569432062593 2656 4226 2911 4384 4282 870 3483 2905 4571 3554 1729 3977 M10119 GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that stops or reduces the activity of a phosphoprotein phosphatase. 8/18 Gene Ontology BP GO:0032515 0.147859119791321 0.249186894080256 3485 3009.63636363636 3484 0.0158730158730159 1128 0.509448760713938 -0.390590987985177 -1 1.16698932338516 3484 1128 3537 1709 4038 4113 2727 3756 1462 2958 4194 3978 M11196 GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. 31/50 Gene Ontology BP GO:0046825 0.147702232965409 0.249186894080256 3950 3175.63636363636 3484 0.0144239921826235 1464 1.45023161899474 1.45023161899474 1 3.32203147102992 3947 3593 2348 3387 1528 3674 4327 1464 3484 2554 4626 3979 M16333 GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. 20/61 Gene Ontology BP GO:0046640 0.545730182047855 0.656892630271955 3895 3357.45454545455 3484 0.0692206992142335 2010 0.370950819076956 -0.319017641067666 -1 0.256980272308703 3634 3052 2010 3416 2449 2974 3891 3891 3655 4476 3484 3980 M12629 GO_TELOMERE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_LOCALIZATION.html Any process in which a telomere is transported to, and/or maintained in, a specific location. 5/12 Gene Ontology BP GO:0034397 0.423597995661395 0.542406368961902 1865 2905.09090909091 3485 0.0536047579519098 1122 0.248595007368163 -0.248595007368163 -1 0.250697891476676 1864 3485 3941 3931 3651 1122 1146 3466 3938 3542 1870 3981 M13021 GO_LYSOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_LOCALIZATION.html Any process in which a lysosome is transported to, and/or maintained in, a specific location. 15/47 Gene Ontology BP GO:0032418 0.975190071998702 0.999999998379914 3435 3600.90909090909 3485 0.285410115803716 2681 0.329899159350897 -0.241926766692711 -1 7.04134913067825e-10 4635 3431 2681 3895 3432 3951 3253 3294 3927 3626 3485 3982 M11505 GO_HISTONE_H2A_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_UBIQUITINATION.html The modification of histone H2A by addition of one or more ubiquitin groups. 15/20 Gene Ontology BP GO:0033522 0.926888261869475 0.972722749462082 4090 3718.18181818182 3486 0.211637240845553 2585 0.153030074062367 -0.154095660234408 -1 0.00697686846595825 4088 4510 3329 4225 4329 3122 3486 2585 4559 3274 3393 3983 M12433 GO_RNA_SURVEILLANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SURVEILLANCE.html The set of processes involved in identifying and degrading defective or aberrant RNAs. 9/14 Gene Ontology BP GO:0071025 0.386086746459241 0.506813899861537 4225 3529.81818181818 3486 0.0476190476190476 2274 0.254947649025792 0.228329447266974 1 0.28562959990942 4222 2274 3907 3311 3966 3245 3482 4452 2447 3486 4036 3984 M15498 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 20/37 Gene Ontology BP GO:1900101 0.237270564788668 0.347961854805366 3490 3297.09090909091 3486 0.0243222307672738 1575 0.29399314160484 -0.239824436505762 -1 0.511627408445118 3486 3244 3027 3707 1829 4314 2080 1575 4184 4293 4529 3985 M10585 GO_FOREBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 5/20 Gene Ontology BP GO:0048853 0.275742742869669 0.392721949430635 4630 3130.18181818182 3487 0.0317460317460317 1180 1.46584243959724 1.46584243959724 1 2.25854857607359 4630 1255 3609 1991 4407 4165 3289 3487 1940 1180 4479 3986 M13407 GO_REGULATION_OF_FEVER_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEVER_GENERATION.html Any process that modulates the rate or extent of fever generation. 3/13 Gene Ontology BP GO:0031620 0.18772403995574 0.292386017280947 1920 2938.81818181818 3487 0.0205768611222181 1207 0.550442752784327 0.776496047334066 1 1.11582462513642 1919 3582 4069 3487 3750 2773 1512 1207 3969 3731 2328 3987 M12863 GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). 7/17 Gene Ontology BP GO:1901070 0.752976904969928 0.832993035448028 2480 3180.72727272727 3488 0.130491652125295 2010 0.24009583949196 -0.373238403196757 -1 0.0723245973348991 2478 3764 3971 3582 3449 2071 2807 3488 3778 3590 2010 3988 M16244 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI.html The directed movement of a protein to a specific location in the Golgi apparatus. 9/19 Gene Ontology BP GO:0072600 0.794365288350515 0.869867460804585 3490 3461.63636363636 3489 0.146291427017271 1775 0.283586262984935 -0.233268824245108 -1 0.0651755096677297 3489 3333 4534 3644 4288 1775 3123 2732 4368 4452 2340 3989 M10667 GO_MEMBRANE_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. 16/45 Gene Ontology BP GO:0044091 0.161385165508919 0.258740097879113 4075 3216.81818181818 3490 0.0158730158730159 1582 1.51935086267539 -1.51935086267539 -1 3.38613455216053 4071 4141 2481 2830 3461 3568 4037 3490 1582 2100 3624 3990 M10706 GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization of an epithelial cell. 15/37 Gene Ontology BP GO:0090162 0.396720431936561 0.518281644761241 4555 3340.72727272727 3491 0.0449037344087232 2058 1.46584243959724 1.46584243959724 1 1.58818279623024 4553 2891 2541 3491 2191 3559 4571 4377 2643 2058 3873 3991 M13481 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE.html The directed movement of a protein to a specific location in a membrane. 163/432 Gene Ontology BP GO:0090150 0.597318307603006 0.701403364238937 2765 3541.27272727273 3491 0.0793650793650794 2340 1.36593332707115 1.55124392447517 1 0.798634606140866 2763 4589 3491 4570 3090 4400 2340 3957 2868 2580 4306 3992 M14247 GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 9/27 Gene Ontology BP GO:0071360 0.626237468884525 0.727632774782495 3495 3257 3491 0.0937258842432637 1378 0.610681132932434 0.610681132932434 1 0.320093516824373 3491 3612 4213 2759 4315 1378 2607 2706 3863 3956 2927 3993 M11143 GO_POSITIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COAGULATION.html Any process that activates or increases the frequency, rate or extent of coagulation. 11/46 Gene Ontology BP GO:0050820 0.205116250801075 0.313377674389401 3495 3255.18181818182 3492 0.0206527851737407 1104 0.463418647704469 -0.338957934137461 -1 0.886446700510133 3492 2269 1104 2609 3715 4589 2900 3550 4023 3178 4378 3994 M15643 GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. 22/31 Gene Ontology BP GO:0046827 0.331985719788672 0.452690072534157 3110 3111.45454545455 3493 0.0360124355219477 1459 1.45023161899474 1.45023161899474 1 1.89476014967732 3108 3657 1869 3493 2250 4339 4364 1459 3511 2369 3807 3995 M13305 GO_VACUOLAR_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_ACIDIFICATION.html Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. 9/18 Gene Ontology BP GO:0007035 0.0765897756730953 0.158445571591463 3665 2929.45454545455 3494 0.00793650793650794 78 1.7829099868158 -0.801505046067566 -1 5.41491592220224 3663 2901 4049 668 3494 3919 4509 4017 78 1605 3321 3996 M10612 GO_CELLULAR_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 56/108 Gene Ontology BP GO:0034644 0.593508000267068 0.700292030466417 4575 3535.90909090909 3496 0.078576524083959 2215 1.05077947290469 1.05077947290469 1 0.617117068441564 4573 4447 2215 4235 2549 2393 3496 4531 4389 2777 3290 3997 M11808 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. 13/26 Gene Ontology BP GO:1902116 0.311860117477767 0.429027118651636 3955 3414.81818181818 3496 0.0334076825776927 1419 0.290289193263646 0.257864439441618 1 0.404961251938846 4637 2570 3010 3319 4075 3496 3787 1419 3954 3345 3951 3998 M15127 GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that activates or increases the frequency, rate or extent of DNA recombination. 5/22 Gene Ontology BP GO:0045911 0.309681705824253 0.426409300160737 2710 3179.45454545455 3496 0.036381923603512 1465 0.285183506129739 -0.30222189181709 -1 0.400716073120866 2706 3869 4357 4487 4593 1526 2126 1465 3496 4188 2161 3999 M15919 GO_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION.html The process in which a methyl group is covalently attached to a molecule. 137/308 Gene Ontology BP GO:0032259 0.244638720105641 0.357412705302232 1940 3085.54545454545 3496 0.0251828609358712 741 0.245850937706347 -0.257759591054399 -1 0.416985964051048 1940 4591 3433 4598 3496 741 3617 2287 3947 4377 914 4000 M11206 GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. 102/249 Gene Ontology BP GO:0051054 0.597318307603006 0.701403364238937 3515 3174.72727272727 3497 0.0793650793650794 2220 1.45895769169445 1.45895769169445 1 0.853024139909835 4351 3829 2408 3511 2645 2469 3513 3594 2885 2220 3497 4001 M16281 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. 46/94 Gene Ontology BP GO:1901989 0.928422952668625 0.973722107350446 3375 3428.72727272727 3497 0.213156203151737 1981 1.36008236682747 -0.989745402399581 -1 0.0597058572495952 3371 3975 1981 3497 4287 3829 2991 2886 3908 2720 4271 4002 M13414 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS.html Splicing of RNA via a series of two transesterification reactions. 157/364 Gene Ontology BP GO:0000375 0.669372643481162 0.760807144108454 1495 3222.63636363636 3498 0.0957187501648188 1400 0.726514731951174 -0.498005606198256 -1 0.327412580794736 1491 4490 3498 4524 3758 1400 3285 2839 4217 3734 2213 4003 M13842 GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. 16/25 Gene Ontology BP GO:0090083 0.51939048177555 0.6324495166231 2640 3100.90909090909 3498 0.0644391637368882 1170 0.333990943727917 -0.314326727225212 -1 0.252254282014174 2639 3812 2580 3498 2414 1170 4024 3776 3881 3850 2466 4004 M14534 GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. 43/110 Gene Ontology BP GO:0031023 0.978161938897681 0.999999998379914 2980 3311.18181818182 3498 0.293650793650794 2616 1.08125035744157 -0.862559895960135 -1 2.71078973069121e-09 2979 3879 2739 3610 3682 2616 3543 3498 3898 2693 3286 4005 M13539 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. 123/271 Gene Ontology BP GO:0071826 0.236555414385785 0.347242108439203 1760 3007.27272727273 3499 0.0242391011877493 670 0.20048802824962 -0.21348017630276 -1 0.349587624844685 1760 4534 3499 4608 3776 670 3043 2025 4072 3770 1323 4006 M15192 GO_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 34/99 Gene Ontology BP GO:0043331 0.597318307603006 0.701403364238937 3320 3480.90909090909 3500 0.0793650793650794 2609 1.22669328210816 1.22669328210816 1 0.71722366441421 3318 4128 3053 3500 3816 3406 3894 3626 2849 2609 4091 4007 M11119 GO_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING.html The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. 254/612 Gene Ontology BP GO:0006605 0.65872362562255 0.754242612519236 4100 3466.36363636364 3501 0.0931089596414591 1741 1.38505367619906 1.38505367619906 1 0.64397749945424 4100 4385 3501 4419 2662 1741 4218 4034 3349 2909 2812 4008 M14657 GO_CELLULAR_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 101/213 Gene Ontology BP GO:0071478 0.360875506738581 0.481063731779279 4235 3277.18181818182 3501 0.0398790392503934 2120 1.47646205994878 1.47646205994878 1 1.78106529227264 4233 4083 2169 3867 2120 2296 3501 4227 3270 2594 3689 4009 M13963 GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. 15/29 Gene Ontology BP GO:0045683 0.91410065408 0.963270389671684 3875 3307.36363636364 3502 0.2 1599 0.377945373061188 -0.358099977853575 -1 0.0233151088772153 3871 1599 2229 3243 4369 2427 4500 3502 3779 3893 2969 4010 M16568 GO_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_AGING.html Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 28/53 Gene Ontology BP GO:0090342 0.0605990260718458 0.140610333858861 4420 2995.36363636364 3502 0.00566687042758016 1058 1.38975139692581 -1.38975139692581 -1 4.49443555417957 4416 3838 2013 3502 1058 3792 4095 2175 3799 2526 1735 4011 M11490 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE.html The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 223/551 Gene Ontology BP GO:0072594 0.779443176293617 0.857480396990891 4545 3460.90909090909 3503 0.128394332868721 1660 1.27393932155765 1.24389286332127 1 0.322905223991103 4545 4243 3503 4115 2887 1660 4239 4083 3423 2896 2476 4012 M13730 GO_ECTODERMAL_PLACODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_DEVELOPMENT.html The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0071696 0.0112217958721349 0.0441101679359682 3505 3012.54545454545 3503 0.00112788698405818 446 1.07272638267715 -1.07272638267715 -1 5.51929124495736 3503 3514 4123 2460 446 3358 4002 4143 3816 1325 2448 4013 M15688 GO_ECTODERMAL_PLACODE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_MORPHOGENESIS.html The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0071697 0.0112217958721349 0.0441101679359682 3505 3043 3504 0.00112788698405818 447 1.07272638267715 -1.07272638267715 -1 5.51929124495736 3504 3515 4441 2461 447 3359 4003 4139 3817 1338 2449 4014 M15785 GO_ECTODERMAL_PLACODE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_FORMATION.html The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 6/22 Gene Ontology BP GO:0060788 0.0112217958721349 0.0441101679359682 3505 3045.81818181818 3505 0.00112788698405818 448 1.07272638267715 -1.07272638267715 -1 5.51929124495736 3505 3516 4457 2462 448 3360 4004 4145 3818 1339 2450 4015 M16313 GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. 9/18 Gene Ontology BP GO:1903209 0.140712867879258 0.241348299062946 3630 3159.63636363636 3505 0.0150508021839746 1269 0.394266791015497 -0.219964126654929 -1 0.923916944166475 3628 2436 4546 2157 1551 3505 3684 3120 1269 4467 4393 4016 M12504 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY.html The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. 8/14 Gene Ontology BP GO:0000244 0.569368281033116 0.677840238163271 3295 3368.27272727273 3506 0.0807987600015045 1894 0.164178203900594 -0.216569058716406 -1 0.105240295625326 3292 3965 3920 4212 4445 2561 2613 1894 3759 3506 2884 4017 M13031 GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. 16/36 Gene Ontology BP GO:0014742 0.741029450967027 0.822716341664253 4215 3490.63636363636 3506 0.115578838793119 2139 0.315333015094319 -0.228734634163618 -1 0.101441519549927 4215 2970 2962 3303 3608 4594 3418 2139 3506 3630 4052 4018 M13249 GO_DNA_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEMETHYLATION.html The removal of a methyl group from one or more nucleotides within an DNA molecule. 3/14 Gene Ontology BP GO:0080111 0.135829125285923 0.234182929336258 1940 2566 3506 0.0144924346992914 578 0.359721876991197 -0.359721876991197 -1 0.860837396283081 1936 3795 4037 3723 3506 578 697 1678 3889 3686 701 4019 M12389 GO_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE.html Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. 468/1049 Gene Ontology BP GO:0000278 0.913260005732958 0.962821572801572 3070 3614.27272727273 3507 0.199291405802713 2069 1.06510146466927 -0.800068248468342 -1 0.0665234333383164 3066 4577 3348 4486 4633 2069 4118 3507 4041 2923 2989 4020 M14179 GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION.html The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. 7/21 Gene Ontology BP GO:0043046 0.540065694582218 0.652491548255331 3035 3418.27272727273 3507 0.0747276583521636 1358 0.209942317891584 0.250503792403115 1 0.147766423604367 3034 3191 4199 3935 3446 2941 1358 3593 4459 3938 3507 4021 M15139 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY.html Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. 16/36 Gene Ontology BP GO:0010613 0.80302959581625 0.8774926837785 4220 3553.18181818182 3507 0.137310257614898 2257 0.315333015094319 -0.228734634163618 -1 0.0679347916026303 4216 2971 2963 3304 3609 4595 3419 2257 3507 4191 4053 4022 M12348 GO_ERROR_FREE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_FREE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. 9/26 Gene Ontology BP GO:0070987 0.757549255017013 0.837452664534284 3430 3541.90909090909 3508 0.132114660389843 2178 0.219850819528979 -0.208474312851765 -1 0.0642909847707783 3427 3508 3893 3950 2913 2178 4229 3734 4316 3469 3344 4023 M13583 GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 12/25 Gene Ontology BP GO:0090201 0.482032618044782 0.597617475455787 2935 3284.27272727273 3508 0.0580507775216392 1414 0.205480720269529 -0.151037419694277 -1 0.174383292751606 2935 4303 3276 3924 3485 3508 1414 1698 4229 3779 3576 4024 M14955 GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM.html A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). 10/21 Gene Ontology BP GO:0034975 0.185563401792493 0.289701033800452 3455 3203.27272727273 3509 0.0184868636422473 563 0.210022576395652 -0.247866793788651 -1 0.428939273700399 3455 3858 2859 3509 3645 563 2131 3929 4495 4137 2655 4025 M15131 GO_HISTONE_H4_K16_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K16_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. 13/21 Gene Ontology BP GO:0043984 0.0839184282471183 0.158445571591463 3515 3422.72727272727 3511 0.00793650793650794 939 0.827888949868591 -0.84157669908996 -1 2.51440010400979 3511 4302 3309 3721 4014 3304 2841 4291 939 4190 3228 4026 M12528 GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING.html Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. 8/18 Gene Ontology BP GO:0006349 0.41775221506432 0.537291837823722 3505 3268.90909090909 3512 0.0526492909561526 1641 0.35898482263758 0.333695426370753 1 0.367628163982918 3501 2321 3925 3459 3971 3625 2570 1641 3726 3512 3707 4027 M16552 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 6/18 Gene Ontology BP GO:0010661 0.610583881881892 0.713013320819323 4620 3422.36363636364 3512 0.09 983 0.342213063988967 -0.324590039029116 -1 0.190823816512348 4618 983 4579 1990 3512 2850 3364 3672 3432 4529 4117 4028 M11964 GO_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PROCESSING.html Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. 477/1051 Gene Ontology BP GO:0006396 0.664252044962889 0.758888347628615 2020 3253 3513 0.0944544370639953 1386 0.966971872787854 -0.600497533032462 -1 0.439802866275257 2017 4642 3513 4530 4067 1386 3832 2789 3884 2935 2188 4029 M13321 GO_REGULATION_OF_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 10/23 Gene Ontology BP GO:0044030 0.665536994515952 0.758975695142582 3040 3318.09090909091 3513 0.0947700443412283 1885 0.243277899521722 -0.228724268742064 -1 0.110602683935617 3039 4344 2571 4147 3513 3145 1885 1990 4387 3709 3769 4030 M16669 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN.html The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. 5/23 Gene Ontology BP GO:0006123 0.350216656561512 0.473516580202417 3515 3679.36363636364 3513 0.0421955346020358 2151 0.145823282369818 -0.178009506713558 -1 0.179708789261187 3513 3031 4601 3486 2151 2873 4109 4517 4351 4558 3283 4031 M12423 GO_NCRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_PROCESSING.html Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. 239/510 Gene Ontology BP GO:0034470 0.846103159714052 0.912957697083975 2285 3389.36363636364 3514 0.156448132537118 1826 0.979699182909658 -0.622861546586804 -1 0.147075142346209 2282 4585 3514 4423 4488 1826 4174 2919 3713 2931 2428 4032 M14621 GO_DNA_GEOMETRIC_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_GEOMETRIC_CHANGE.html The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. 46/101 Gene Ontology BP GO:0032392 0.924096117253468 0.971044544412536 2100 3537.72727272727 3514 0.208946570923892 2096 0.231215675640223 -0.258011787700746 -1 0.0111996387200179 2096 4500 3179 4468 4527 2103 3280 3514 4516 4058 2674 4033 M11392 GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE.html A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. 14/27 Gene Ontology BP GO:0035584 0.875484932260134 0.935816355965542 3720 3357.72727272727 3516 0.172539166554128 1865 0.420061557771848 0.427502412093617 1 0.0459360775115019 3717 2389 1865 2948 3571 3011 4228 3516 3982 3241 4467 4034 M10289 GO_NCRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). 9/26 Gene Ontology BP GO:0034661 0.0976811069117221 0.179191378661053 3945 3285.36363636364 3517 0.0102260825439934 1344 0.26852538797168 -0.207373592910446 -1 0.761077324768852 3941 2577 3562 3517 1344 2859 3432 4551 3678 2994 3684 4035 M11556 GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. 5/20 Gene Ontology BP GO:2000846 0.0765897756730953 0.158445571591463 4565 2911.09090909091 3517 0.00793650793650794 242 0.683236579776346 0.454180086054459 1 2.0750731453778 4054 1135 3768 609 3842 4561 4563 2443 242 3288 3517 4036 M10466 GO_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DEGRANULATION.html The regulated exocytosis of secretory granules by a leukocyte. 20/68 Gene Ontology BP GO:0043299 0.724275567815517 0.80836813975179 3520 3537.36363636364 3518 0.110524247076262 2545 0.319371649626129 0.340668946425848 1 0.112003701242447 3518 4197 2545 4440 2789 4243 3116 2559 4111 3036 4357 4037 M13932 GO_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. 207/504 Gene Ontology BP GO:0051052 0.666845572569539 0.758975695142582 4580 3467 3518 0.0950925901207973 2116 1.3773220479365 1.3773220479365 1 0.62617901439308 4577 4488 2702 4236 2675 2116 4169 3762 3518 2770 3124 4038 M15072 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. 10/39 Gene Ontology BP GO:0046636 0.867810142009206 0.929896720366661 2870 3536.45454545455 3518 0.168027595613495 2368 0.291751141472316 0.264415325494017 1 0.0349566248495006 2866 3994 2368 4251 4479 3357 3074 2421 4400 4173 3518 4039 M16259 GO_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. 928/2309 Gene Ontology BP GO:0009056 0.0192965004240422 0.0645022688760461 4435 2890.54545454545 3518 0.00194661369951066 187 1.23356676951111 1.46680522656129 1 5.57406379285719 4432 3518 4536 3808 602 187 4165 4156 2296 2745 1351 4040 M16466 GO_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION.html Long distance growth of a single axon process involved in cellular development. 19/63 Gene Ontology BP GO:0048675 0.620706531053662 0.721748165209655 4025 3235.90909090909 3518 0.0843594171446648 1535 1.98900160281705 1.98900160281705 1 1.0691767577654 4022 1649 1535 2826 3918 4357 4075 3518 2945 2253 4497 4041 M14714 GO_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_HOMEOSTASIS.html Any process involved in the balance between food intake (energy input) and energy expenditure. 9/20 Gene Ontology BP GO:0097009 0.0708731816447012 0.157071208771526 3520 3195.18181818182 3519 0.00732405134176739 817 1.42267534279842 1.42267534279842 1 4.34127111538562 3519 3998 4280 3639 3120 4208 2780 817 3151 1614 4021 4042 M12554 GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. 11/26 Gene Ontology BP GO:0051447 0.63389956273523 0.731410454716618 4010 3679.09090909091 3520 0.0873015873015873 2721 0.350178398224861 -0.231595538632393 -1 0.180559579459194 4008 3294 2721 3075 4389 4582 4437 2958 2927 3520 4559 4043 M12041 GO_BILE_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. 11/33 Gene Ontology BP GO:0006699 0.0335307191566261 0.0932003951166524 4030 3098.09090909091 3521 0.00309572240788151 781 0.50491279453589 -0.50491279453589 -1 1.97517810911769 4026 1043 2052 1526 781 4639 4594 4270 3521 3401 4226 4044 M15874 GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 21/58 Gene Ontology BP GO:0072523 0.948168867542611 0.989736522482091 4005 3477.45454545455 3521 0.235909836400682 2558 0.55936453995665 -0.55936453995665 -1 0.00951303899389046 4005 3243 2712 3521 3308 3026 3808 3844 3859 4368 2558 4045 M10038 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION.html The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. 8/46 Gene Ontology BP GO:0050908 0.632427457617131 0.731410454716618 2480 3359.27272727273 3522 0.0952380952380952 1488 1.49234186417521 1.49234186417521 1 0.769483843015036 2479 4106 3522 3578 4366 4123 4320 2604 3018 1488 3348 4046 M14535 GO_PIRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. 5/15 Gene Ontology BP GO:0034587 0.116060814984067 0.206384666400239 3525 3247.72727272727 3523 0.0122609162598568 1442 0.376975710204641 -0.448081309144619 -1 0.980653618939499 3523 3826 4249 3765 1442 2714 3651 2261 2955 4040 3299 4047 M15035 GO_NEUROTRANSMITTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 9/41 Gene Ontology BP GO:0042133 0.119584961859016 0.211051044652775 3855 3100.45454545455 3525 0.01265542287219 1460 0.545942310158455 0.462907354744351 1 1.40007614621327 3854 2319 4336 2400 1460 2758 1844 3837 3525 4162 3610 4048 M15653 GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE.html The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. 22/47 Gene Ontology BP GO:0042769 0.896116920047091 0.950141781178041 2660 3508.27272727273 3526 0.186055142984614 2001 0.218972048881078 -0.243699060664362 -1 0.0184618594190014 2657 4294 3371 4349 4083 2001 3304 3526 3958 4326 2722 4049 M12576 GO_MACROMOLECULAR_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_REMODELING.html The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. 9/28 Gene Ontology BP GO:0034367 0.214139132665174 0.322775948981753 3025 3419.18181818182 3527 0.0238095238095238 1739 0.483922949675687 0.359381959782188 1 0.902095158724525 4514 3023 3934 3022 2712 2844 4133 4296 1739 3527 3867 4050 M16937 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. 114/261 Gene Ontology BP GO:1903322 0.118486053912893 0.209813405155439 2485 3111.09090909091 3527 0.011399478487157 417 0.858982002181133 0.858982002181133 1 2.21119884915006 2481 3905 3379 3919 4260 417 3527 2342 3911 4634 1447 4051 M15416 GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 10/21 Gene Ontology BP GO:0009074 0.619641216060763 0.721024416080517 3200 3396 3529 0.0841259201978794 1533 1.93847904430292 1.93847904430292 1 1.04522470616476 3199 3821 1533 3112 4116 4297 4053 4600 3387 1709 3529 4052 M16744 GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION.html A cellular localization which involves only one organism. 533/1309 Gene Ontology BP GO:1902580 0.0734242469788986 0.158445571591463 4080 3111.36363636364 3530 0.00759694363990079 319 1.20506725154122 1.33504963908875 1 3.65993678640321 4078 4383 4615 4417 1571 319 3530 4492 2877 2764 1179 4053 M13142 GO_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_IMPORT.html The directed movement of the hexose monosaccharide glucose into a cell or organelle. 9/18 Gene Ontology BP GO:0046323 0.214139132665174 0.322775948981753 3285 3029.09090909091 3534 0.0238095238095238 973 0.458001399242489 0.490020789191869 1 0.853774025840294 3283 973 4020 1895 3073 3583 3562 3890 1847 3660 3534 4054 M13366 GO_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_GROWTH.html The increase in size or mass of an entire multicellular organism, as opposed to cell growth. 48/121 Gene Ontology BP GO:0035264 0.161385165508919 0.258740097879113 3535 3308.18181818182 3534 0.0158730158730159 1524 1.80828051178766 1.80828051178766 1 4.03006393811623 3534 4089 2769 3002 4112 4105 3773 2275 1524 2735 4472 4055 M12616 GO_MICROTUBULE_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_DEPOLYMERIZATION.html The removal of tubulin heterodimers from one or both ends of a microtubule. 7/16 Gene Ontology BP GO:0007019 0.918182677152301 0.966256158209006 2315 3452.18181818182 3539 0.221453554079832 2303 0.255406897492145 -0.255406897492145 -1 0.0144527744687957 2315 4476 3938 4379 3570 2303 3480 2625 4482 3539 2867 4056 M14334 GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 12/32 Gene Ontology BP GO:0071236 0.39624950328564 0.517812114763644 3335 3486.27272727273 3539 0.0448359801014835 2189 0.297447250911784 -0.259477793194113 -1 0.322716853273552 3334 3217 2875 2858 2189 3617 3977 4417 4343 3983 3539 4057 M14364 GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 8/13 Gene Ontology BP GO:0009263 0.709888976494649 0.795754350039753 1570 3206.63636363636 3539 0.11639854340458 1570 0.237304134147847 -0.237304134147847 -1 0.0893749970731736 1570 3614 4230 3539 4281 1878 3053 3105 4091 3988 1924 4058 M10138 GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. 8/30 Gene Ontology BP GO:0019682 0.0765897756730953 0.158445571591463 4265 2700.90909090909 3540 0.00793650793650794 66 1.09476899510989 -1.09476899510989 -1 3.32494747714069 4263 976 3540 717 3957 3205 3730 4026 66 1491 3739 4059 M16898 GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS.html A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. 24/66 Gene Ontology BP GO:0061640 0.690380072721337 0.779911113782279 3590 3229 3540 0.101099300109004 1449 0.36173117456122 -0.382305187810173 -1 0.14822978951685 3588 3715 1687 3540 4397 1449 2625 3530 4166 4625 2197 4060 M11554 GO_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_ENGULFMENT.html The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. 18/159 Gene Ontology BP GO:0006911 0.648585607696084 0.744228339333642 2855 3188.54545454545 3541 0.0906923021869804 1722 1.06823553432498 -0.989745402399581 -1 0.520211452186343 2851 4299 1722 3685 4227 4032 2873 1967 3541 2189 3688 4061 M14382 GO_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE.html Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. 95/350 Gene Ontology BP GO:0051321 0.771881751823779 0.850462025087281 2120 3303.72727272727 3541 0.125719259136203 1631 0.294047470596414 -0.287424228676713 -1 0.0785160363667863 2119 4439 1704 4517 3377 1631 3853 3541 4521 3995 2644 4062 M14424 GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. 11/29 Gene Ontology BP GO:0031442 0.604481158275899 0.707488282801865 4165 3438 3541 0.0808659941621357 2570 0.219819953343611 -0.241124314925771 -1 0.125394269855516 4162 4304 3145 3953 2570 2607 3541 2918 3870 4011 2737 4063 M10437 GO_MULTI_ORGANISM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_TRANSPORT.html The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. 38/115 Gene Ontology BP GO:0044766 0.963737517038277 0.999999998379914 3545 3619.81818181818 3543 0.260323886216713 2343 0.247601083291632 -0.263919768118549 -1 4.84339122197828e-10 3543 4396 3071 4457 3808 2343 4066 3523 4404 3029 3178 4064 M11438 GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. 39/164 Gene Ontology BP GO:0030518 0.681628464298714 0.772467893516946 3730 3465.90909090909 3543 0.0988186343512311 2657 1.31739699471586 1.31739699471586 1 0.560667384938968 3726 4164 2687 3598 2702 3543 3401 3988 3220 2657 4439 4065 M12649 GO_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASOCONSTRICTION.html A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure. 14/39 Gene Ontology BP GO:0042310 0.143988829144653 0.245854514411452 3590 3373.18181818182 3545 0.0140343915002706 1006 0.520938417527885 -0.605428477016266 -1 1.20487042127198 3587 4175 1006 4145 4223 2229 3492 4402 2947 3545 3354 4066 M15622 GO_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEEDING_BEHAVIOR.html Behavior associated with the intake of food. 30/131 Gene Ontology BP GO:0007631 0.21980026975342 0.330376384741058 4345 3304.54545454545 3546 0.0223114548867963 1777 0.38244317062434 0.24160137113198 1 0.698250241229128 4343 4196 1901 4282 1777 2961 3546 1852 2865 4317 4310 4067 M11750 GO_RNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLATION.html Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. 30/57 Gene Ontology BP GO:0001510 0.983678432848931 0.999999998379914 3555 3713.72727272727 3551 0.312102382799615 2579 0.166495588869676 -0.171810373047038 -1 2.67728392713236e-10 3551 4455 3286 4304 4491 2579 4298 3090 4562 3335 2900 4068 M13693 GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that activates or increases the frequency, rate or extent of receptor internalization. 8/32 Gene Ontology BP GO:0002092 0.585125360932651 0.691633668739892 2465 3269.72727272727 3553 0.0842188736495371 1441 0.21919687152639 -0.275922182279987 -1 0.133228662852109 2464 4472 4117 4286 3476 1451 1441 3553 4601 3806 2300 4069 M11741 GO_HISTONE_H2A_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_MONOUBIQUITINATION.html The modification of histone H2A by addition of a single ubiquitin group. 13/15 Gene Ontology BP GO:0035518 0.924196821399741 0.971044544412536 3990 3680.54545454545 3555 0.209042039081236 2577 0.132381418501356 -0.136051799166325 -1 0.00641229898823265 3989 4470 3304 4168 3555 3368 3598 2577 4588 3332 3537 4070 M16846 GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY.html Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. 7/22 Gene Ontology BP GO:0051482 0.000353873536173709 0.00375980509943828 3560 2450.54545454545 3556 3.53929900722357e-05 59 1.51430131785667 1.51430131785667 1 13.9380386285242 3556 440 4625 213 59 4375 4151 4282 160 1434 3661 4071 M12693 GO_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PAIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 14/52 Gene Ontology BP GO:0048265 0.401512665568065 0.523070512410922 3230 3555.27272727273 3557 0.0455959590801409 1300 0.381374943973332 0.238025645597264 1 0.407422343873152 3230 3920 1300 4399 3168 4448 3453 4186 3466 3557 3981 4072 M12815 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that stops or decreases the rate or extent of glial cell proliferation. 7/16 Gene Ontology BP GO:0060253 0.386086746459241 0.506813899861537 4035 3341.27272727273 3557 0.0476190476190476 2026 0.37020521613038 -0.31747304473901 -1 0.41475796381004 4031 2322 3964 2026 3425 2525 4366 4628 2329 3581 3557 4073 M16521 GO_MONOAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOAMINE_TRANSPORT.html The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/24 Gene Ontology BP GO:0015844 0.735754357604904 0.817446155147061 3185 3513.81818181818 3557 0.124611607952676 2611 0.286247806755288 -0.412209660251523 -1 0.0951174349569962 3185 3557 4574 3604 2866 2611 3056 3666 3991 4521 3021 4074 M12719 GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-beta production. 27/71 Gene Ontology BP GO:0032728 0.232850105696956 0.342669743502683 3795 3118.81818181818 3559 0.0238095238095238 1473 1.18643787599035 1.18643787599035 1 2.09469698511747 3791 1897 2866 2673 3559 3715 3887 4347 1855 1473 4244 4075 M12721 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. 16/58 Gene Ontology BP GO:0002686 0.0839184282471183 0.158445571591463 3850 3237.63636363636 3560 0.00793650793650794 1177 0.800508376728112 -0.800508376728112 -1 2.4312419510135 3850 3957 1243 3822 2224 4303 3402 3446 1177 3560 4630 4076 M14745 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 6/16 Gene Ontology BP GO:0034375 0.702397417514147 0.788880311929895 3565 3482.27272727273 3562 0.11414290156658 2124 0.422927304153571 0.379016317885104 1 0.165334429209852 3562 3197 4285 3376 3646 3684 2913 2124 3456 4088 3974 4077 M10997 GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that activates or increases the frequency, rate, or extent of cellular extravasation. 6/16 Gene Ontology BP GO:0002693 0.912077643679383 0.962148529715562 2925 3597.09090909091 3564 0.215830526529494 2273 0.413247225891191 0.329463263100032 1 0.0262867102014821 2922 3263 3669 4368 4643 4435 2273 3564 4460 3133 2838 4078 M13948 GO_OOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. 18/71 Gene Ontology BP GO:0009994 0.0839184282471183 0.158445571591463 4555 2964.54545454545 3566 0.00793650793650794 460 1.81687673106179 -1.38916827744188 -1 5.51807708323059 4552 3566 1618 2187 4352 2378 4145 4317 460 1068 3967 4079 M12754 GO_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. 17/50 Gene Ontology BP GO:0009112 0.804335486102439 0.878564003175915 3135 3471.27272727273 3567 0.137831788473213 2149 0.648828184364399 0.648828184364399 1 0.138477342249354 3132 4097 2688 3531 2935 4038 2149 4060 4131 3567 3856 4080 M13432 GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION.html An organelle organization which involves another organism. 16/25 Gene Ontology BP GO:1902590 0.320740483207309 0.439184497849703 2155 3325.18181818182 3567 0.0345483678622099 913 0.151798174961264 0.167880613453619 1 0.20590704717121 2155 4565 3029 4413 3567 2841 913 4172 4610 3740 2572 4081 M14058 GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of ATP metabolic process. 17/63 Gene Ontology BP GO:1903580 0.850621352955467 0.915455969875182 3665 3343.27272727273 3568 0.158730158730159 1855 0.396690397622411 0.269457613729924 1 0.0577651970336762 3568 3663 2124 3665 4179 1855 2942 4524 3417 3909 2930 4082 M15650 GO_MULTI_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves another organism. 16/25 Gene Ontology BP GO:1902592 0.320740483207309 0.439184497849703 2160 3378.18181818182 3568 0.0345483678622099 914 0.151798174961264 0.167880613453619 1 0.20590704717121 2156 4566 3030 4414 3568 2842 914 4161 4611 4325 2573 4083 M11699 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT.html Any process that modulates the frequency, rate or extent of cellular response to heat. 53/95 Gene Ontology BP GO:1900034 0.885250834879955 0.942278685545078 3685 3447.09090909091 3569 0.178660546422162 1966 0.282356411656767 -0.227633342321742 -1 0.0276739887379073 3685 3831 3206 3988 3502 1966 3614 3569 4076 3317 3164 4084 M15661 GO_MATURATION_OF_5_8S_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA.html Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. 15/29 Gene Ontology BP GO:0000460 0.979021715613748 0.999999998379914 4330 3622.36363636364 3569 0.296225327264547 2515 0.224293365589391 -0.205849947707668 -1 4.22090543724991e-10 2989 3569 3216 3474 4328 2515 4312 3656 4219 4327 3241 4085 M16892 GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. 8/20 Gene Ontology BP GO:0042789 0.499543441148917 0.616364655130061 2885 3497 3570 0.0668818465564895 2016 0.496427998764759 0.559833291559631 1 0.396021036996228 2881 3724 4633 3289 2435 3570 4201 2016 3593 4622 3503 4086 M11965 GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. 11/22 Gene Ontology BP GO:1903894 0.952700554364259 0.993024940991392 4325 3768.72727272727 3571 0.242238792811229 2274 0.188067215951934 -0.174611916019838 -1 0.00217005891054937 4322 4568 3091 4460 3503 2274 3571 4423 4583 3381 3280 4087 M14752 GO_MULTICELLULAR_ORGANISMAL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_SIGNALING.html The transfer of information occurring at the level of a multicellular organism. 50/189 Gene Ontology BP GO:0035637 0.912207156538424 0.962148529715562 2900 3419.90909090909 3571 0.198412698412698 1541 1.3172927667316 -1.28127221255727 -1 0.0837931659307928 2900 3272 2034 2979 4403 4504 3908 4222 3571 1541 4285 4088 M14395 GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. 2/11 Gene Ontology BP GO:0045741 0.715396707367189 0.800961396746048 2710 3427.2 3572.5 0.130318981921126 1764 0.218767291733004 0.218767291733004 1 0.0800413598063465 2707 3930 4233 NA 3562 2747 1764 3583 4428 4000 3318 4089 M12305 GO_HEMIDESMOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMIDESMOSOME_ASSEMBLY.html Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. 13/25 Gene Ontology BP GO:0031581 0.592056914349063 0.698937262477167 4020 3408.63636363636 3573 0.0782779830434182 1511 0.369141384490875 -0.263411141272036 -1 0.217973120752534 4020 3543 1511 3573 3824 2311 3104 4314 4054 3461 3780 4090 M12780 GO_REGULATION_OF_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ORGANIZATION.html Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. 15/33 Gene Ontology BP GO:0090224 0.600463926357133 0.703495839030071 3280 3263.09090909091 3573 0.0800212034593678 1287 0.231981358165262 -0.269457439994787 -1 0.134495806798072 3278 4415 2648 4042 4191 1287 3982 1959 4441 3573 2078 4091 M13681 GO_ACROSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_ASSEMBLY.html The formation of the acrosome from the spermatid Golgi. 8/18 Gene Ontology BP GO:0001675 0.582167543116668 0.688663414698264 3520 3561.63636363636 3575 0.0835680595706963 2597 0.232302658221258 -0.187318184769047 -1 0.142842560681045 3520 3725 4115 3494 2597 3049 3331 3575 4136 3803 3833 4092 M14965 GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 15/40 Gene Ontology BP GO:0061028 0.977804168436716 0.999999998379914 4145 3495 3575 0.292606543473481 2454 0.313449663127987 0.322600478203861 1 6.60202779962747e-10 2705 4144 2454 4340 3575 3745 2580 3558 4105 4141 3098 4093 M14361 GO_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. 10/18 Gene Ontology BP GO:0030851 0.632471127639865 0.731410454716618 3355 3100.54545454545 3577 0.086978421148619 1395 0.397025491745062 -0.249557176974337 -1 0.204714957278218 3355 3854 1803 3577 3706 1395 2778 3885 4095 3985 1673 4094 M14779 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. 8/46 Gene Ontology BP GO:0050962 0.632427457617131 0.731410454716618 2480 3433.72727272727 3579 0.0952380952380952 1520 1.49234186417521 1.49234186417521 1 0.769483843015036 2480 4107 4291 3579 4367 4124 4321 2614 3019 1520 3349 4095 M14465 GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. 4/18 Gene Ontology BP GO:0033604 0.987945623895701 0.999999998379914 2725 3559.36363636364 3580 0.357142857142857 2587 0.445213670606628 0.459770138296448 1 1.01210862781164e-09 2723 2587 4240 3580 3845 4093 3192 3255 4056 4024 3558 4096 M16638 GO_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. 37/88 Gene Ontology BP GO:0055072 0.0839184282471183 0.158445571591463 2355 3053.09090909091 3580 0.00793650793650794 1219 1.31212748984869 -0.831099373833084 -1 3.98509183817348 2355 3711 2890 3669 3791 3580 1875 4075 1219 2643 3776 4097 M16681 GO_SYNCYTIUM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNCYTIUM_FORMATION.html The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. 16/57 Gene Ontology BP GO:0006949 0.923523264129276 0.970776209045105 3945 3407.27272727273 3580 0.208405683154743 2114 0.329035915014093 -0.345804578892076 -1 0.0160877724406453 3944 4067 2114 4015 3580 2809 2238 2581 4420 4562 3150 4098 M10269 GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 11/26 Gene Ontology BP GO:0051284 0.0842713192367518 0.15885981941382 4035 3090.09090909091 3581 0.00797125589244511 1224 1.29994081892301 1.29994081892301 1 3.94248406499949 4035 3992 2404 3187 1224 3581 4088 3780 1554 1772 4374 4099 M14978 GO_REGULATION_OF_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUTAMATE_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of glutamate. 9/26 Gene Ontology BP GO:0014048 0.424973893378989 0.544018138119285 1980 3315.81818181818 3581 0.0538309098190862 1652 0.379486847949673 0.325118323701597 1 0.380840768579299 1980 3997 4327 3287 2923 3907 3581 1652 3592 4144 3084 4100 M12821 GO_REGULATION_OF_STEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of steroid hormone secretion. 7/30 Gene Ontology BP GO:2000831 0.147859119791321 0.249186894080256 4435 3145.27272727273 3582 0.0158730158730159 1318 0.590505850787735 0.450013630048045 1 1.35266601162084 4433 1410 3965 1318 3117 4451 4177 2926 1355 3582 3864 4101 M16916 GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. 9/21 Gene Ontology BP GO:0046112 0.850630407203762 0.915455969875182 3010 3641.45454545455 3583 0.173150972949348 2084 0.648828184364399 0.648828184364399 1 0.0944809558790962 3009 3860 4637 3583 3094 3260 2084 4150 4357 4630 3392 4102 M14052 GO_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G2_M_PHASE_TRANSITION.html The cell cycle process by which a cell in G2 phase commits to M phase. 80/243 Gene Ontology BP GO:0044839 0.912207156538424 0.962148529715562 3590 3684.81818181818 3586 0.198412698412698 2681 0.93366777733764 -0.523746058863399 -1 0.0593907299111063 3428 4032 2691 4143 3922 3419 3586 4557 3586 2681 4488 4103 M10686 GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE.html Any process in which a protein is transported to, or maintained at, the kinetochore. 7/13 Gene Ontology BP GO:0034501 0.998729230433658 0.999999998379914 3590 3569.90909090909 3587 0.486658139197711 2980 0.266194313445469 -0.296234777732636 -1 5.33996585922103e-10 2980 3410 3617 3437 4006 3192 4005 3587 4372 3073 3590 4104 M16499 GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. 8/16 Gene Ontology BP GO:0002903 0.818139378593154 0.890023696065607 3620 3506.27272727273 3594 0.156715986937845 2356 0.362404684383429 -0.288571083703588 -1 0.0696046218689228 3620 3365 4571 3375 3594 3098 2356 2365 3606 4516 4103 4105 M12715 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX.html The joining of the small ribosomal subunit, ternary complex, and mRNA. 10/23 Gene Ontology BP GO:0001731 0.991130964772011 0.999999998379914 4645 3831.27272727273 3596 0.349206349206349 3223 0.205154441506964 -0.221696431068088 -1 3.70975679848118e-10 4641 3399 3368 3596 4526 3223 4504 3511 4029 3559 3788 4106 M14830 GO_CELLULAR_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a cell. 8/16 Gene Ontology BP GO:0009992 0.921463602291816 0.96883050394948 3015 3561.27272727273 3596 0.224633384836051 2500 0.384275607424646 -0.284506614750623 -1 0.0200595917602536 3013 2762 4300 3670 3298 3596 3506 3860 4561 4108 2500 4107 M15211 GO_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRITY_CHECKPOINT.html A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. 92/197 Gene Ontology BP GO:0031570 0.967363199437191 0.999999998379914 2945 3516.18181818182 3596 0.267373696567219 2379 1.18847832685675 -1.3261771808088 -1 2.99716649026479e-09 2943 4495 3051 4478 4061 2379 3596 3779 4192 2752 2952 4108 M12421 GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. 18/47 Gene Ontology BP GO:2001258 0.423065394725666 0.541873828334142 4130 3525 3597 0.048772854524945 2196 1.29994081892301 1.29994081892301 1 1.31304213881903 4128 4411 2679 4104 2239 3597 3491 3567 3772 2196 4591 4109 M12897 GO_RESPONSE_TO_GROWTH_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 15/67 Gene Ontology BP GO:0060416 0.000890921941735792 0.00749375104253493 3995 2476.27272727273 3597 8.1025721654092e-05 86 0.900416075626817 0.900416075626817 1 7.26391685415562 3995 280 2117 351 86 4217 3854 3813 287 3597 4642 4110 M13147 GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING.html Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. 4/19 Gene Ontology BP GO:0010738 0.900849582143098 0.953852818675121 4450 3723.90909090909 3598 0.206349206349206 2974 0.220454649728179 -0.188474861460575 -1 0.0171701822534221 4449 3202 4021 2974 3414 4606 4209 3355 3598 3661 3474 4111 M12907 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. 8/16 Gene Ontology BP GO:0070198 0.526828662343759 0.638659394063205 2665 3240.18181818182 3600 0.0720985723126712 1316 0.242682903626803 -0.210211122683531 -1 0.179382812067536 2664 4152 3979 4205 3967 2580 1316 2166 4556 3600 2457 4112 M13603 GO_PARTURITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARTURITION.html The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. 4/26 Gene Ontology BP GO:0007567 0.375279741295901 0.496275659025026 3375 3577.27272727273 3600 0.0459556608825624 2204 0.554366160919556 -0.422020433343465 -1 0.640284672158626 3372 3453 4102 3595 2204 3950 4206 3259 3600 3786 3823 4113 M14133 GO_TOXIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_TRANSPORT.html The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/59 Gene Ontology BP GO:1901998 0.736387127061902 0.817953452380003 4310 3432.09090909091 3601 0.114149160063354 1559 0.584451347281639 -0.584451347281639 -1 0.193609912418957 4307 3562 2455 3851 4436 1559 3601 3228 4256 3929 2569 4114 M14570 GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 15/48 Gene Ontology BP GO:0006509 0.0984425198469519 0.180374356609865 4195 3258.09090909091 3602 0.00937680444168503 1303 1.74485001602008 1.74485001602008 1 4.92647432181537 4194 3602 1862 3412 1303 4227 3551 3746 3745 2079 4118 4115 M15724 GO_LONG_CHAIN_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_TRANSPORT.html The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 19/73 Gene Ontology BP GO:0015909 0.444930749558325 0.563967641332051 3765 3193.27272727273 3602 0.0521080532116823 1168 0.479481852406291 -0.34322556956599 -1 0.452725738592536 3761 1168 1356 3171 2613 3602 4214 2854 3755 4338 4294 4116 M15375 GO_PROTEIN_K63_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. 18/32 Gene Ontology BP GO:0070536 0.891073518496821 0.9463070325665 3600 3510.63636363636 3603 0.182539682539683 2208 1.48034281358945 1.48034281358945 1 0.134679067683082 3598 4096 2618 4306 3610 2874 3725 4469 3510 2208 3603 4117 M10564 GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 9/17 Gene Ontology BP GO:0046130 0.89845090407627 0.951944210577773 3030 3466.63636363636 3604 0.204449769090181 2096 0.18843479297988 -0.206848174796055 -1 0.0152984950582144 3027 4180 3604 4277 4196 2096 3881 2845 4579 3048 2400 4118 M16786 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. 12/19 Gene Ontology BP GO:1990440 0.375503262254471 0.496429853829018 3945 3372.54545454545 3604 0.0418978074847549 2027 0.328589839124205 -0.301422148330001 -1 0.379348100736656 3943 3604 2318 3146 2148 2027 4078 3946 4391 4592 2905 4119 M11674 GO_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPAIR.html Any process that modulates the frequency, rate or extent of DNA repair. 48/109 Gene Ontology BP GO:0006282 0.673130228437206 0.764516548589517 3810 3470.72727272727 3605 0.096657900017893 2684 1.21455215107271 1.21455215107271 1 0.537614253467707 3807 3088 2904 3605 2684 4043 3710 3524 3711 2734 4368 4120 M15962 GO_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_MEDIATED_ENDOCYTOSIS.html An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. 27/51 Gene Ontology BP GO:0072583 0.494615082745549 0.611583975815601 3880 3563 3606 0.060154274389051 2373 0.298107005783568 0.288000353661788 1 0.241638753974523 3879 2777 3282 2997 2373 3606 4271 4370 2893 4391 4354 4121 M12939 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. 6/16 Gene Ontology BP GO:0033008 0.829154703133627 0.899898383976024 2345 3413.09090909091 3609 0.161968578068936 2083 0.181007819685403 0.19896788035793 1 0.0314725506650754 2342 4479 3984 4490 3126 2613 2083 4250 4377 3609 2191 4122 M14453 GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. 13/25 Gene Ontology BP GO:0045605 0.832656756310386 0.902855048937207 4360 3404.54545454545 3609 0.15 1338 0.406796921245398 -0.356765809540186 -1 0.0685316917282145 4358 1338 2288 2677 4458 3253 4035 4090 3609 4021 3323 4123 M11267 GO_CELLULAR_COMPONENT_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MAINTENANCE.html The organization process that preserves a cellular component in a stable functional or structural state. 10/26 Gene Ontology BP GO:0043954 0.834338739663584 0.903233457752032 4395 3690.54545454545 3611 0.1507802470067 2126 0.131288157228538 -0.177100985992038 -1 0.0220269764773205 4393 4419 3315 4226 4185 3262 3221 3611 4632 3206 2126 4124 M12943 GO_PLATELET_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_MORPHOGENESIS.html Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. 17/38 Gene Ontology BP GO:0036344 0.538779620915134 0.651107178529143 4415 3209.72727272727 3611 0.0679349438934852 1179 0.270586463451933 -0.304320179385065 -1 0.191397784475401 2624 4412 2473 4565 4148 1179 2711 3646 4412 3611 1526 4125 M13478 GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY.html Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. 7/26 Gene Ontology BP GO:0001539 0.748046941801099 0.828921706630669 3615 3283.45454545455 3611 0.128771721449924 2102 0.900270877697453 -0.900270877697453 -1 0.27846205920797 2909 4521 4084 3959 3004 2102 3611 2217 3612 3750 2349 4126 M11004 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 5/18 Gene Ontology BP GO:0060261 0.925223208736807 0.971903022209275 3615 3492.54545454545 3612 0.228427602714795 2326 0.160103129795049 0.218984757914163 1 0.00752185225342623 3075 4028 3670 3612 4257 3276 2326 3614 4146 3136 3278 4127 M11898 GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. 13/28 Gene Ontology BP GO:1903205 0.986107082665205 0.999999998379914 4500 3621.63636363636 3613 0.322104047233905 2864 0.278706350704067 -0.235628473239894 -1 5.67412836414619e-10 4496 3603 2864 3613 4062 3619 3291 3008 4068 3365 3849 4128 M15205 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. 14/41 Gene Ontology BP GO:0035850 0.024167281200079 0.0749056652950379 3840 3337.54545454545 3615 0.00222153799023265 687 0.621210128606663 -0.640555172212199 -1 2.65390638590262 3840 2308 687 2961 3196 4525 4216 3615 2532 4210 4623 4129 M15316 GO_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_LOCALIZATION.html A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. 32/79 Gene Ontology BP GO:0031503 0.576548258621659 0.684282608583938 3250 3324.27272727273 3616 0.0751462029504772 1250 0.592680838380628 -0.592680838380628 -1 0.370673685490624 3248 4062 3095 4178 3276 1250 3961 3616 3654 4236 1991 4130 M11462 GO_DETECTION_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_OTHER_ORGANISM.html The series of events in which a stimulus from another organism is received and converted into a molecular signal. 20/63 Gene Ontology BP GO:0098543 0.647118611920861 0.742970255971453 3620 3474.45454545455 3617 0.0903478691331095 1956 1.29644110978073 1.29644110978073 1 0.634959341791896 3617 4014 1956 3972 2636 3342 4607 4327 3988 2282 3478 4131 M13131 GO_ESTABLISHMENT_OF_TISSUE_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_TISSUE_POLARITY.html Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 13/29 Gene Ontology BP GO:0007164 0.751985672431077 0.832094727620946 3715 3532.09090909091 3617 0.119047619047619 1943 1.46584243959724 1.46584243959724 1 0.444166275686528 3715 3848 2206 3617 4532 3502 4463 4636 3216 1943 3175 4132 M10626 GO_RESPONSE_TO_IMMOBILIZATION_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IMMOBILIZATION_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. 7/28 Gene Ontology BP GO:0035902 0.844337935660361 0.911688612853734 3615 3605 3618 0.169732040538123 2646 0.357727838557655 -0.265236819859421 -1 0.0545234145496813 3614 3767 3612 3700 3071 4591 3618 2646 3687 3063 4286 4133 M14494 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. 19/67 Gene Ontology BP GO:0002833 0.687277757198574 0.777855898013402 2965 3300 3619 0.100284208937013 2026 0.292387057593518 -0.238051916399077 -1 0.121085883016232 2965 3717 2809 3699 4156 2644 2979 2026 3657 4029 3619 4134 M11496 GO_XENOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XENOPHAGY.html The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. 66/157 Gene Ontology BP GO:0098792 0.878859116702268 0.937274247587117 3275 3688.90909090909 3620 0.174603174603175 2865 0.701222236703204 -0.701222236703204 -1 0.074883101760692 3275 3620 2865 4425 3846 2914 3754 4528 3481 3271 4599 4135 M15525 GO_CARDIAC_CHAMBER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_FORMATION.html The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. 6/19 Gene Ontology BP GO:0003207 0.480311452746527 0.595801783356164 3625 3302.90909090909 3621 0.0633565194065799 1293 0.53913844756531 -0.422217948971932 -1 0.460249702535995 3621 1293 4418 1839 2404 4557 3842 2850 3241 4296 3971 4136 M14096 GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. 42/106 Gene Ontology BP GO:0008286 0.514011397665828 0.627050688219243 4485 3304.90909090909 3625 0.0634920634920635 2128 1.13667853373169 1.30426527756376 1 0.874566751607885 4481 3273 2159 3625 3807 2852 3901 3785 2692 2128 3651 4137 M13028 GO_REGULATION_OF_HEXOKINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEXOKINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hexokinase activity. 5/14 Gene Ontology BP GO:1903299 0.787740496127363 0.864652275063676 2190 3327.63636363636 3628 0.143580170285912 1966 0.378809210047211 0.469778361236264 1 0.0908154304417079 2190 3080 3996 2970 3907 4041 1966 4474 4264 3628 2088 4138 M14439 GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 7/29 Gene Ontology BP GO:0006144 0.0131910812138693 0.0497532007116125 3750 3255.72727272727 3628 0.00132700437787664 481 0.648828184364399 0.648828184364399 1 3.20952677128624 3750 2944 4236 2394 481 3375 2568 4418 4003 4016 3628 4139 M14777 GO_POSITIVE_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SIZE.html Any process that increases cell size. 12/21 Gene Ontology BP GO:0045793 0.569300316224061 0.677840238163271 4470 3485.45454545455 3628 0.0737181781381415 2022 0.437117615112764 -0.343845432626784 -1 0.28019789468309 4470 2932 2022 3899 2496 3388 3628 4400 3361 4095 3649 4140 M15218 GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. 9/17 Gene Ontology BP GO:0034314 0.0474229971545878 0.11808546489473 4150 3107.81818181818 3628 0.00484665014008537 981 0.625059557561618 -0.625059557561618 -1 2.20132752563916 4148 2605 4371 2451 981 3647 2136 1658 3628 4215 4346 4141 M10642 GO_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION.html A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 63/129 Gene Ontology BP GO:0006261 0.952367426889651 0.993002911082113 1955 3584.81818181818 3630 0.241755168916699 1952 0.839316232100865 -0.839316232100865 -1 0.0097153487867913 1952 4446 3303 4473 4381 2798 3652 3630 4477 3065 3256 4142 M13034 GO_MULTIVESICULAR_BODY_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 22/34 Gene Ontology BP GO:0036257 0.886565452855793 0.943399907413338 3635 3733.36363636364 3633 0.179520455002062 2093 0.181119885905389 0.188881259633106 1 0.0173966438061692 2864 4618 3066 4518 3292 4395 2093 4404 4552 3632 3633 4143 M15464 GO_POSITIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_KILLING.html Any process that activates or increases the frequency, rate or extent of cell killing. 31/84 Gene Ontology BP GO:0031343 0.0745338276157039 0.158445571591463 4125 3121.45454545455 3633 0.0070168748957448 1161 0.410212023752018 -0.304442598240491 -1 1.24586414068935 4121 1931 1878 2381 1161 4250 2644 3864 3633 4282 4191 4144 M16808 GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase A. 9/16 Gene Ontology BP GO:0034199 0.961213368894553 0.998597358171985 3635 3724.09090909091 3633 0.277449499885908 2849 0.302260942036216 -0.280572785752356 -1 0.00069939900128717 3633 3334 4620 3633 4624 2939 3058 2849 4433 4597 3245 4145 M12040 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. 88/246 Gene Ontology BP GO:0070972 0.991251207914824 0.999999998379914 3325 3840.09090909091 3634 0.35001344650153 2794 0.158592529487834 0.144435222706747 1 2.46621469315978e-10 3322 4600 3504 4485 3634 4126 2794 3559 4472 3400 4345 4146 M10789 GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 7/25 Gene Ontology BP GO:0002281 0.840704751309109 0.908822388900627 3205 3371.90909090909 3635 0.167814235853395 1905 0.195942870006902 -0.281753399521393 -1 0.030881921623473 3203 4421 3635 3759 3536 1905 3639 3738 3940 3094 2221 4147 M13067 GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 17/33 Gene Ontology BP GO:0010869 0.816521443770307 0.888471774882948 4250 3658.36363636364 3636 0.142857142857143 2465 0.390969209210257 0.377773766645722 1 0.0762156323910345 4249 3388 2465 3442 3636 4521 4565 2805 3320 3643 4208 4148 M13776 GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT.html The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. 19/41 Gene Ontology BP GO:0043001 0.698152987361708 0.785443256680497 4510 3704.27272727273 3636 0.103174603174603 3105 0.266298246557966 -0.209994865151717 -1 0.106020459899131 4509 4134 3292 4190 3311 3434 3895 3409 3105 3832 3636 4149 M14805 GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of DNA biosynthetic process. 55/119 Gene Ontology BP GO:2000278 0.698152987361708 0.785443256680497 3640 3568.54545454545 3638 0.103174603174603 1805 1.75894475465316 1.75894475465316 1 0.700282989092093 3638 4498 1805 4041 3149 3334 4519 4312 3110 2429 4419 4150 M10840 GO_ICOSANOID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_TRANSPORT.html The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. 7/31 Gene Ontology BP GO:0071715 0.97805785598086 0.999999998379914 3420 3474.63636363636 3639 0.317460317460317 2182 0.500001226222834 -0.410061940439521 -1 1.158431296495e-09 3419 2182 3646 2674 4465 2999 4057 4092 3948 3100 3639 4151 M15564 GO_RRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. 8/20 Gene Ontology BP GO:0016075 0.0738108076226155 0.158445571591463 4115 3460.45454545455 3639 0.00763835374613126 1204 0.28320879295055 -0.218636681864392 -1 0.860139778973986 4115 2437 4424 2868 1204 3069 3558 4606 3639 4309 3836 4152 M10813 GO_COENZYME_A_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 7/17 Gene Ontology BP GO:0015936 0.057316937433533 0.135368812869288 4630 3602.09090909091 3642 0.00588512915087105 1077 0.204770590450139 -0.199372558171969 -1 0.675049041718495 4627 3260 3642 3543 1077 3211 4640 4540 3894 3096 4093 4153 M11828 GO_PROTEIN_LOCALIZATION_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_LYSOSOME.html A process in which a protein is transported to, or maintained in, a location within a lysosome. 18/30 Gene Ontology BP GO:0061462 0.894539789557695 0.949119799569556 3270 3572.72727272727 3645 0.184939445195925 2116 0.633042077535849 0.633042077535849 1 0.054495804840389 3269 3387 3017 3645 3757 3928 2116 4643 4253 3350 3935 4154 M11928 GO_HISTONE_H3_K9_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K9_MODIFICATION.html The modification of histone H3 at a lysine in position 9 of the histone. 12/20 Gene Ontology BP GO:0061647 0.943712354754118 0.986193216998283 3755 3443 3646 0.23015873015873 2426 0.277454384350655 -0.260388665588789 -1 0.00635903357646656 3752 3184 3070 3646 3734 2426 4062 4100 3708 3374 2817 4155 M15938 GO_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORT.html The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 25/104 Gene Ontology BP GO:0015908 0.140089961241587 0.240368695508015 4500 3193.81818181818 3646 0.0136269824100651 1000 0.514350491952889 -0.409315536689296 -1 1.20876727193833 4497 1026 1000 2132 2955 2949 4517 3751 3646 4386 4273 4156 M10918 GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL.html Any virus-mediated process that modulates the levels of viral proteins in a cell. 5/18 Gene Ontology BP GO:0046719 0.7184702227596 0.803433825691913 4140 3565.27272727273 3647 0.119047619047619 3052 0.25915143634939 -0.260335905370075 -1 0.0935001826209756 4136 3647 3659 4121 3841 3292 3052 3374 3198 3119 3779 4157 M14606 GO_APOPTOTIC_DNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_DNA_FRAGMENTATION.html The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. 6/18 Gene Ontology BP GO:0006309 0.410131854187438 0.53265516055728 2670 3264.09090909091 3647 0.0514166566384845 1626 0.293435769604132 -0.405659319534159 -1 0.304693460078317 2669 3968 4256 3940 3924 2214 3208 1626 3647 4051 2402 4158 M14885 GO_LATERAL_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. 14/49 Gene Ontology BP GO:0021670 0.724869093752253 0.80864180737427 3650 3342.90909090909 3648 0.110698480388521 1768 0.271523822423552 -0.220638621136809 -1 0.0950719490498235 3648 4464 1768 4288 4602 2070 2135 3251 4538 4124 1884 4159 M15172 GO_ESTROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 5/23 Gene Ontology BP GO:0006703 0.109138568231565 0.195951420069279 2290 2973.27272727273 3648 0.011490116907023 964 0.243276637764972 0.294673762976395 1 0.65365689204533 2288 3648 4367 4061 4258 1471 1603 964 4493 4200 1353 4160 M11272 GO_RRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. 157/371 Gene Ontology BP GO:0016072 0.981904678700305 0.999999998379914 3955 3825.54545454545 3649 0.305620427297309 3017 0.493393016758395 -0.493393016758395 -1 1.14078256526069e-09 3953 4590 3512 4613 3474 3017 4170 3649 4515 3207 3381 4161 M10878 GO_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. 3/16 Gene Ontology BP GO:0006182 0.984701249552351 0.999999998379914 2660 3635 3650 0.341636726358948 2659 0.309692313657072 0.309692313657072 1 6.50167920849638e-10 2659 4313 3650 4009 3766 3091 3588 4234 4565 3109 3001 4162 M15329 GO_NUCLEOSIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSPORT.html The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/20 Gene Ontology BP GO:0015858 0.873235755943548 0.934416597106681 3690 3614.45454545455 3650 0.171191394105638 2721 0.262608612238276 0.229163914089623 1 0.0293657379725684 3686 3639 2980 3191 3078 4455 3650 2721 4055 4240 4064 4163 M15609 GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. 7/18 Gene Ontology BP GO:0051044 0.0179809560181969 0.0616584776901686 3270 3418.90909090909 3650 0.00181281264253734 440 0.446764002864043 -0.224489243598879 -1 2.05198111587834 3270 3116 4430 2852 4001 4381 4419 440 2735 4314 3650 4164 M15338 GO_GOLGI_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LOCALIZATION.html Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. 9/19 Gene Ontology BP GO:0051645 0.554480856102875 0.665577718429589 4565 3450.90909090909 3652 0.0776693582758799 1987 0.233320769864722 -0.264491108095222 -1 0.156583466003369 4563 1987 4391 2458 2540 3652 4061 3118 3022 4245 3923 4165 M15873 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. 39/96 Gene Ontology BP GO:2001022 0.0738422063334638 0.158445571591463 3625 3423.72727272727 3652 0.00694943614737802 1154 1.21455215107271 1.21455215107271 1 3.68874358757377 3622 3775 3094 3657 1154 4096 4025 3652 3347 2662 4577 4166 M16365 GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 20/62 Gene Ontology BP GO:0021680 0.00870553493055554 0.0368122028074402 3525 3183.45454545455 3653 0.000794561392963505 293 1.17287447352151 -1.03069309216194 -1 6.38425754448111 3521 4132 1108 3653 4544 4467 3592 293 4026 1155 4527 4167 M11500 GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 31/76 Gene Ontology BP GO:0002755 0.865412014258462 0.927755248719011 4490 3663.54545454545 3654 0.166666666666667 2555 1.29644110978073 1.29644110978073 1 0.160262597526902 4487 3654 2733 3559 4011 3220 4497 4190 3443 2555 3950 4168 M12883 GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS.html The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 13/31 Gene Ontology BP GO:0009072 0.571752703957994 0.679981507294304 4400 3305.09090909091 3654 0.0741988975848144 878 1.48458606823243 -1.03069309216194 -1 0.943919454976977 4399 4021 1592 3572 3731 3271 3654 3763 3194 878 4281 4169 M15485 GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. 76/170 Gene Ontology BP GO:0051053 0.63897025268477 0.736346210775723 3655 3405.09090909091 3654 0.0884581021891226 1557 1.00744291305309 1.00744291305309 1 0.508289678681252 3654 4603 3262 4567 2629 1557 3727 4050 4336 2847 2224 4170 M15048 GO_PROTEIN_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSMEMBRANE_TRANSPORT.html The directed movement of a protein across a membrane by means of some agent such as a transporter or pore. 35/79 Gene Ontology BP GO:0071806 0.465981522057794 0.580826820010117 3360 3343.18181818182 3655 0.0554338247484903 1072 0.201198605818828 -0.222243877138168 -1 0.180201467486602 3358 4322 3382 4234 2839 1072 3796 3655 4432 4167 1518 4171 M10904 GO_NEGATIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPAIR.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. 6/17 Gene Ontology BP GO:0045738 0.815244492587349 0.888471774882948 4375 3621.27272727273 3656 0.155383153836785 2654 0.184482922705177 -0.213322068029631 -1 0.0359631455663431 4371 2654 3656 3425 3018 2980 4079 4485 4235 3116 3815 4172 M10447 GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. 32/77 Gene Ontology BP GO:2000573 0.35943518917414 0.479556776820555 4330 3384 3657 0.0396825396825397 2016 2.46711003640163 2.46711003640163 1 2.98885029808577 4330 4323 2016 3790 3376 2430 4328 4179 2219 2576 3657 4173 M11831 GO_MRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. 5/13 Gene Ontology BP GO:0016556 0.862020567174249 0.924973767827603 3555 3626.09090909091 3657 0.17968352186895 2095 0.103504500956613 0.106282054170425 1 0.0133072752897145 3552 4378 3814 4214 3657 3363 2095 2831 4554 3351 4078 4174 M15166 GO_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. 160/378 Gene Ontology BP GO:0033044 0.581697718935079 0.688307055091471 3770 3314.72727272727 3658 0.0761743395472709 1261 1.15373689574795 -0.978889588504004 -1 0.710415556734994 3766 4532 2748 4410 3222 1261 4210 3711 3658 2833 2111 4175 M10948 GO_ROUNDABOUT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUNDABOUT_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 5/15 Gene Ontology BP GO:0035385 0.214139132665174 0.322775948981753 3750 3039.45454545455 3661 0.0238095238095238 1183 1.98900160281705 1.98900160281705 1 3.70775702633108 3747 1752 3661 1902 3801 4573 4096 2772 1658 1183 4289 4176 M12635 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS.html Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. 35/80 Gene Ontology BP GO:0050690 0.678300478480034 0.769259677963556 3770 3450.18181818182 3661 0.0979662960560473 2388 1.14672566625037 1.14672566625037 1 0.495899356233023 3767 4453 3200 4355 2693 2388 3704 4154 3661 2615 2962 4177 M13444 GO_MALE_MEIOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. 18/155 Gene Ontology BP GO:0007140 0.368491335874327 0.489249434505148 4255 3240 3661 0.0409247915985746 1737 0.300397516734373 -0.275895746794127 -1 0.354015881897534 4253 3661 1737 4267 2137 2118 2052 3791 4569 3742 3313 4178 M16696 GO_CENTROSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_LOCALIZATION.html Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. 17/32 Gene Ontology BP GO:0051642 0.646220771018363 0.742674019761946 2580 3430.63636363636 3662 0.0901377084133547 1486 0.202343376605198 0.22956362328155 1 0.0992349558872355 2579 4200 3193 4453 3662 2769 1486 3706 4598 4568 2523 4179 M11391 GO_POSITIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BEHAVIOR.html Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 9/31 Gene Ontology BP GO:0048520 0.7909545698261 0.866745826694025 1815 3407.18181818182 3664 0.144885899556941 1812 0.310574451978747 0.384134913562263 1 0.0732187289517422 1812 4307 3735 4543 4344 2688 1867 3664 4529 3240 2750 4180 M12290 GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY.html Any process that modulates the activity of the enzyme lipoprotein lipase. 5/17 Gene Ontology BP GO:0051004 0.918986889777588 0.966664279392239 3875 3519.81818181818 3666 0.222222222222222 2586 0.285628282315775 -0.219485645121605 -1 0.0159640822833602 3499 2586 3885 2633 3875 4137 3871 3047 3666 3458 4061 4181 M12679 GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary amino compound. 6/25 Gene Ontology BP GO:1901160 0.657894442786319 0.753479007858135 3910 3284.09090909091 3671 0.101711142017207 1319 1.03069309216194 -1.03069309216194 -1 0.48093943569839 3910 3671 3946 3681 3994 3476 1582 2902 3375 1319 4269 4182 M11032 GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 7/16 Gene Ontology BP GO:0071545 0.973510964353134 0.999999998379914 2330 3654.72727272727 3673 0.304484817388955 2326 0.1641223991648 0.156000943122862 1 2.61390248092551e-10 2326 4477 3673 4537 4517 3313 2917 3849 4575 3144 2874 4183 M13244 GO_COVALENT_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COVALENT_CHROMATIN_MODIFICATION.html The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. 184/403 Gene Ontology BP GO:0016569 0.29151783066532 0.410139707445999 3205 3338.36363636364 3673 0.030844335173246 778 0.827888949868591 -0.84157669908996 -1 1.21637305300589 3202 4586 3482 4607 4238 778 3673 3506 3910 3683 1057 4184 M15043 GO_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. 346/813 Gene Ontology BP GO:0016071 0.823337534310346 0.894630510602138 3475 3545.27272727273 3675 0.145801957993403 1770 1.14117021503041 1.37085769596219 1 0.209464617973864 3471 4580 3518 4529 3675 1770 4385 3800 3794 2927 2549 4185 M12743 GO_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYUBIQUITINATION.html Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. 135/313 Gene Ontology BP GO:0000209 0.394766397357409 0.516455447430389 3855 3457.81818181818 3676 0.0446229134410114 954 1.46867985469611 1.46867985469611 1 1.5998031014398 3855 4592 3388 4562 3676 954 4157 4354 3268 2861 2369 4186 M12792 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. 25/56 Gene Ontology BP GO:0010882 0.726270090971166 0.809038395484434 2955 3352.45454545455 3676 0.111111111111111 2127 1.38933387508025 1.38933387508025 1 0.485341434719051 2954 3950 2127 3863 4533 3866 2528 3676 3162 2440 3778 4187 M13222 GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. 6/14 Gene Ontology BP GO:0050812 0.822215241348815 0.893860863771335 3340 3648.54545454545 3676 0.15862529237237 1841 0.300859595293453 -0.299223873430064 -1 0.0556503879022028 4123 3336 4035 4055 3367 1841 4510 3456 4398 3676 3337 4188 M13248 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 20/47 Gene Ontology BP GO:0071157 0.011445147384098 0.0446928673712085 4195 3338.09090909091 3676 0.00104592056624323 428 0.329312683936049 -0.244922991632866 -1 1.68722427961975 4195 2638 3013 3676 428 3446 4465 4509 2570 3685 4094 4189 M13413 GO_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G1_S_PHASE_TRANSITION.html The cell cycle process by which a cell in G1 phase commits to S phase. 65/140 Gene Ontology BP GO:0044843 0.888244529133816 0.944382722410879 1645 3334.63636363636 3676 0.180632033282498 1645 1.21015125839419 1.21015125839419 1 0.114158342682004 1645 3942 2940 3618 4204 3853 2492 4013 3731 2567 3676 4190 M15875 GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE.html Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 7/17 Gene Ontology BP GO:0010984 0.0398524698589502 0.104657815359223 3900 3434.81818181818 3676 0.00405857454367994 905 0.34876955981518 0.350151801479413 1 1.29769627064887 3897 2511 4471 3363 905 3348 3690 3102 3676 4369 4451 4191 M16467 GO_DERMATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. 7/14 Gene Ontology BP GO:0030205 0.822436702569706 0.893860863771335 3300 3597.36363636364 3676 0.158730158730159 1667 0.409806969269271 0.476432356947417 1 0.0758025244363348 3297 1667 4569 2441 4480 4167 3676 3399 3388 4512 3975 4192 M14407 GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. 65/140 Gene Ontology BP GO:0000082 0.888244529133816 0.944382722410879 1650 3336.36363636364 3677 0.180632033282498 1646 1.21015125839419 1.21015125839419 1 0.114158342682004 1646 3943 2941 3619 4205 3854 2493 4022 3732 2568 3677 4193 M16810 GO_AMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving AMP, adenosine monophosphate. 10/18 Gene Ontology BP GO:0046033 0.717752302627504 0.802824365478077 3680 3665.18181818182 3678 0.108631444061145 2750 0.648828184364399 0.648828184364399 1 0.234904737402143 3678 3578 2912 3630 2777 4496 2750 4007 4080 4598 3811 4194 M13615 GO_DIOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. 6/12 Gene Ontology BP GO:0034311 0.0354638969279383 0.0962917388517063 4085 3429.63636363636 3683 0.00360429043845747 844 0.384949033521525 -0.31753592515525 -1 1.48518244984416 4082 2184 4105 3030 844 4326 3683 3653 3530 3789 4500 4195 M13204 GO_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an mRNA molecule. 59/117 Gene Ontology BP GO:0031124 0.688663356891335 0.77872965563723 3750 3572.09090909091 3685 0.100647343775513 2139 0.824416974526559 0.824416974526559 1 0.339889000202455 3746 4318 3457 4502 2715 2139 3685 3876 4022 3671 3162 4196 M14460 GO_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE.html The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. 744/1842 Gene Ontology BP GO:0007049 0.785457194346181 0.862349906206979 4575 3525.54545454545 3685 0.142663338272601 1753 1.15985456802551 1.30521962389946 1 0.283160736114995 3170 4575 4238 4571 3380 1753 3954 3685 3763 2926 2766 4197 M13612 GO_MEIOTIC_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEPARATION.html The process in which chromosomes are physically detached from each other during meiosis. 8/12 Gene Ontology BP GO:0051307 0.928006868074916 0.973505623242619 3180 3677.18181818182 3686 0.231349158958858 2556 0.287044177041577 -0.261543003311667 -1 0.0127060835294611 3179 4108 4104 4372 3294 2556 3686 3568 4596 3788 3198 4198 M15733 GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 12/29 Gene Ontology BP GO:1902893 0.0607532649562418 0.140721239830686 3885 3346.36363636364 3686 0.0056817131822012 1060 0.368646134183574 0.312617830898486 1 1.19171702385071 3884 3686 2533 3698 1060 4452 3556 1991 3284 4340 4326 4199 M11044 GO_MALE_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DETERMINATION.html The specification of male sex of an individual organism. 2/17 Gene Ontology BP GO:0030238 0.99533546942597 0.999999998379914 3700 3747.8 3687 0.449219367489763 3149 0.149889324918462 -0.149889324918462 -1 2.23377575618501e-10 3700 4428 3674 NA 3895 3261 4248 3380 4381 3149 3362 4200 M11992 GO_REGULATION_OF_CENTRIOLE_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTRIOLE_REPLICATION.html Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. 9/18 Gene Ontology BP GO:0046599 0.00339276739285055 0.0191172560740353 4175 3506.63636363636 3688 0.000339795844236925 192 0.248504533439405 0.18138376287177 1 1.621100336419 4174 3611 3840 3688 3752 3402 4578 192 4503 3390 3443 4201 M12813 GO_CELL_REDOX_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_REDOX_HOMEOSTASIS.html Any process that maintains the redox environment of a cell or compartment within a cell. 35/76 Gene Ontology BP GO:0045454 0.674521878114067 0.765348260039984 3620 3383.63636363636 3688 0.0970082133423055 1594 0.33798492426037 0.341804961476303 1 0.149001194416886 3619 3947 1844 3715 2687 3788 1594 3688 4274 3580 4484 4202 M15677 GO_GANGLION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLION_DEVELOPMENT.html The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. 9/27 Gene Ontology BP GO:0061548 0.879136193892288 0.937274247587117 3695 3602.63636363636 3691 0.19047619047619 1624 1.49234186417521 1.49234186417521 1 0.159366292121808 3276 3691 4438 3186 3541 4576 4374 3694 3524 1624 3705 4203 M13223 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 20/44 Gene Ontology BP GO:0030947 0.377968949657981 0.499405188748437 3155 3474.72727272727 3692 0.0422423221149575 1272 0.398105402334021 0.334132225552993 1 0.45568028755732 3155 3354 1272 3394 3811 3761 4093 3692 3946 3677 4067 4204 M12612 GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. 16/40 Gene Ontology BP GO:0045822 0.183923829739246 0.287721813166887 3700 3005.09090909091 3697 0.0183073987189543 1003 1.13179372635729 1.37263421167935 1 2.32430770701033 3697 1794 1076 2095 4113 4320 4173 4446 2036 1003 4303 4205 M14381 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. 273/602 Gene Ontology BP GO:0022613 0.900326761911127 0.953516686941916 2415 3581 3698 0.189110479346553 2015 0.493393016758395 -0.493393016758395 -1 0.0387147507592517 2413 4583 3517 4614 3698 2015 4394 3175 4353 3994 2635 4206 M14880 GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that stops or reduces the activity of a monooxygenase. 5/24 Gene Ontology BP GO:0032769 0.950245640406869 0.99101314205056 3700 3626.63636363636 3698 0.259230463492216 2692 0.355839647382736 -0.27359020516082 -1 0.0052955681144852 3698 2987 4309 3294 3365 3063 3917 4267 4179 4122 2692 4207 M14922 GO_MULTI_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_METABOLIC_PROCESS.html A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism. 92/247 Gene Ontology BP GO:0044033 0.992376116363452 0.999999998379914 4155 3884.45454545455 3699 0.358095280163174 3433 0.174265659747222 0.134174992012039 1 2.88480139964487e-10 4155 4539 3506 4527 3642 3498 3433 3492 4108 4130 3699 4208 M15017 GO_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location. 977/2309 Gene Ontology BP GO:0008104 0.0120117457319898 0.0460816150833625 3850 2920 3699 0.00120771709176042 107 1.24506294582 1.46247510937035 1 6.31623825829435 3848 3699 4334 3737 1501 107 4140 4310 2761 2725 958 4209 M15328 GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 7/18 Gene Ontology BP GO:0060457 0.245572443682094 0.358438496075437 2650 3551.54545454545 3699 0.027786260496354 1897 0.32829288604927 0.323053350152468 1 0.555264118348605 2649 3554 4388 3114 1897 3894 4199 3699 3952 4239 3482 4210 M11348 GO_RIBOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_ASSEMBLY.html The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. 36/75 Gene Ontology BP GO:0042255 0.978161938897681 0.999999998379914 4570 3832.27272727273 3700 0.293650793650794 3232 0.159485232272331 -0.152282071174082 -1 2.49005635798668e-10 4566 4454 3489 4172 3700 3447 4217 3373 3900 3232 3605 4211 M15092 GO_PROSTATE_GLAND_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_GROWTH.html The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. 5/17 Gene Ontology BP GO:0060736 0.558447328428011 0.667233902699757 4185 3500.27272727273 3701 0.0784938209460483 2227 0.364033568819484 -0.445117462141144 -1 0.24281445772378 4183 2366 4350 2227 2548 4368 3627 3186 3701 4182 3765 4212 M11209 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html The directed movement of a protein to a specific location in the endoplasmic reticulum. 71/216 Gene Ontology BP GO:0072599 0.927051080415618 0.972722749462082 2700 3758 3702 0.21179700899369 2250 0.127064585930369 0.117210826068073 1 0.00579306324952903 2698 4606 3508 4572 3592 3702 2250 4567 4545 3191 4107 4213 M11424 GO_RESPONSE_TO_COPPER_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COPPER_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. 20/42 Gene Ontology BP GO:0046688 0.221031565962754 0.332111588632549 3735 3174.36363636364 3704 0.0224518255439106 1121 1.21831602395311 -0.930896232997513 -1 2.21383425539895 3733 2260 1121 2154 3999 4497 3590 4104 3704 1145 4611 4214 M13119 GO_GAS_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAS_TRANSPORT.html The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/23 Gene Ontology BP GO:0015669 0.435369722646862 0.553965914565464 2805 3329.09090909091 3704 0.0555555555555556 1867 0.697879496476211 -0.487403887123856 -1 0.679522354647562 2801 1867 4016 2367 3704 4008 3892 3781 2495 3652 4037 4215 M14086 GO_DETECTION_OF_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_BIOTIC_STIMULUS.html The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. 24/76 Gene Ontology BP GO:0009595 0.640580557645421 0.737041574967992 4460 3410.72727272727 3707 0.088828468264137 1355 1.20763157545096 1.20763157545096 1 0.607412653856934 4458 3979 1868 3642 2631 3723 4502 3707 3613 1355 4040 4216 M10600 GO_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. 19/41 Gene Ontology BP GO:0031063 0.988438980056112 0.999999998379914 4600 3562.72727272727 3708 0.333333333333333 2233 1.10159638197239 1.10159638197239 1 2.76512843175136e-09 4597 3095 2489 4137 4013 3457 3544 3942 3975 2233 3708 4217 M15487 GO_RNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an RNA molecule. 70/144 Gene Ontology BP GO:0031123 0.943433089965811 0.986193216998283 3580 3693.90909090909 3708 0.229812285256591 2215 0.824416974526559 0.824416974526559 1 0.0188949809932545 3578 4542 3474 4454 3339 2215 3708 3878 3973 4291 3181 4218 M16665 GO_NEUROTROPHIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. 20/34 Gene Ontology BP GO:0038179 0.878859116702268 0.937274247587117 4035 3620.45454545455 3708 0.174603174603175 2260 0.743128926420273 -0.743128926420273 -1 0.079358292012367 4034 4260 3186 3708 3194 2260 4038 4138 3477 4556 2974 4219 M13924 GO_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 20/54 Gene Ontology BP GO:0034605 0.672341368507863 0.763807431852705 4180 3309.09090909091 3709 0.0964599257453819 1938 1.05077947290469 1.05077947290469 1 0.466728698435051 4178 3537 1938 4119 2683 2249 3772 3850 3709 2293 4072 4220 M14695 GO_HISTONE_H2A_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_ACETYLATION.html The modification of histone H2A by the addition of an acetyl group. 12/18 Gene Ontology BP GO:0043968 0.494808726303774 0.611649290575712 3025 3375.81818181818 3709 0.0601870175281685 1113 0.84157669908996 -0.84157669908996 -1 0.682014762989713 3024 4371 3268 4434 3340 1113 3824 3709 4130 4073 1848 4221 M11252 GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. 14/35 Gene Ontology BP GO:0010833 0.822271468732305 0.893860863771335 4575 3745.72727272727 3713 0.145334634941345 2970 0.258541103795548 -0.23590396658313 -1 0.0478226818505308 4574 3432 3269 3594 2970 3930 3713 4538 3773 3200 4210 4222 M13512 GO_POSITIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXON_EXTENSION.html Any process that activates or increases the frequency, rate or extent of axon extension. 26/54 Gene Ontology BP GO:0045773 0.829897374475325 0.900493926078274 2865 3527.72727272727 3714 0.148735273852291 2629 0.341993791796702 0.351910699830018 1 0.0590908434762145 2862 3714 2629 3800 2991 4483 2725 4226 3668 3762 3945 4223 M15074 GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 24/87 Gene Ontology BP GO:0002275 0.286629153875909 0.40524335001396 4505 3394.54545454545 3714 0.030238290084322 1898 0.294969607413091 0.30973285543137 1 0.439223137861997 2938 4502 2897 4501 1954 3714 2833 1898 3934 4174 3995 4224 M11550 GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. 2/15 Gene Ontology BP GO:0021521 0.83682970665955 0.905476655329828 4045 3750.5 3714.5 0.182447450612347 3081 0.287187081563147 -0.262762512201988 -1 0.0470087278093681 4042 3081 3767 NA 3134 4505 3301 3662 4344 3286 4383 4225 M13083 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. 17/42 Gene Ontology BP GO:0032105 0.943712354754118 0.986193216998283 3485 3765.81818181818 3715 0.23015873015873 3211 0.262302042240414 0.290320152305181 1 0.00601175395013217 3482 3211 3245 4020 3764 4488 4153 3445 3715 3647 4254 4226 M13771 GO_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 15/44 Gene Ontology BP GO:0033198 0.404037260395035 0.525916736757541 3610 3601.72727272727 3715 0.0459626587066541 2205 0.81282113458068 -0.665455983212677 -1 0.861064359453897 3608 3683 2690 3293 2205 4331 3715 4043 3983 3831 4237 4227 M13570 GO_TRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. 13/23 Gene Ontology BP GO:0030488 0.95551428390583 0.994943444757741 3510 3650.27272727273 3716 0.246451929133763 2610 0.206358064323466 -0.210412966266669 -1 0.00172451921192746 3509 4146 2899 4130 4529 2757 3498 3716 4582 3777 2610 4228 M13363 GO_POSITIVE_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HAIR_CYCLE.html Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 5/13 Gene Ontology BP GO:0042635 0.0217742001126982 0.0697224904298329 1590 2654.45454545455 3717 0.00219905416631846 245 0.434079524236941 0.611770959159617 1 1.90576742082888 1589 3769 4061 3773 3805 736 245 2676 4160 3717 668 4229 M15562 GO_PROTEIN_REFOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_REFOLDING.html The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. 17/28 Gene Ontology BP GO:0042026 0.61493465886365 0.717011959091895 2825 3477.36363636364 3719 0.0831013952430277 1301 0.20186829794927 -0.254730819403895 -1 0.110704136384776 2824 4368 2925 4303 3072 1301 4538 3719 4443 4307 2451 4230 M15996 GO_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_DUPLICATION.html The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 17/48 Gene Ontology BP GO:0051298 0.35838113377847 0.479556776820555 3805 3395.72727272727 3719 0.0395389914390543 2113 1.29994081892301 1.29994081892301 1 1.5748501066423 3804 3719 2245 3221 2113 3754 4108 4195 3673 2162 4359 4231 M16950 GO_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MITOCHONDRION.html The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. 32/69 Gene Ontology BP GO:0006626 0.886913761761624 0.943399907413338 3460 3614.72727272727 3720 0.179749806311722 2348 0.196311809173381 -0.209592538240163 -1 0.0188558346575259 3460 3776 3429 4220 3119 2348 3720 3810 4318 4637 2925 4232 M14856 GO_MYELIN_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_ASSEMBLY.html The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. 9/30 Gene Ontology BP GO:0032288 0.700149941082206 0.786546377073478 3975 3361.27272727273 3721 0.113476170399982 1555 0.931951048591966 -0.931951048591966 -1 0.36887846364716 3974 3721 4306 2962 3781 1555 3438 2121 4224 4117 2775 4233 M16829 GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). 7/71 Gene Ontology BP GO:0030520 0.758253916112288 0.838032119140527 3200 3653.90909090909 3721 0.132367233903561 2239 0.151293904819992 -0.1849379177912 -1 0.0440703701124629 3197 4573 4623 4400 3721 2753 3018 2239 4388 4604 2677 4234 M12638 GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0034030 0.279464990482175 0.396563554648148 4485 3556.72727272727 3722 0.0322448108033995 2002 0.212674905503224 -0.237222331117918 -1 0.324273510826297 4483 2759 3943 3477 2002 2733 4514 4202 3722 3543 3746 4235 M13375 GO_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that modulates the frequency, rate, or extent of cellular extravasation. 13/37 Gene Ontology BP GO:0002691 0.133360137449 0.230697137919414 2240 3204.36363636364 3722 0.0129276894539854 989 0.489708720727631 0.664323407629156 1 1.18401096602414 2239 3849 989 4062 3921 3939 1943 3388 3766 3722 3430 4236 M11284 GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. 5/16 Gene Ontology BP GO:0043922 0.130010038431908 0.225924310682095 3985 3449.18181818182 3724 0.0138308235845493 1500 0.25895366382561 -0.238157785858445 -1 0.635018979440398 3984 2948 3724 2526 1500 4156 3595 3930 4049 3212 4317 4237 M12102 GO_CELLULAR_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 8/23 Gene Ontology BP GO:0071318 0.496181572058171 0.612868060405982 2995 3436.81818181818 3724 0.0662569015532296 1268 0.227285682873691 0.205533914805697 1 0.183446740661322 2993 4109 3849 4443 4283 2726 1268 3724 4546 3412 2452 4238 M12519 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. 10/27 Gene Ontology BP GO:0031112 0.988921733069944 0.999999998379914 4280 3757.09090909091 3725 0.335913408729569 2655 0.211839427841673 -0.220442306399897 -1 3.88829461233415e-10 4276 4417 2936 4217 3640 2655 4092 3330 4530 3510 3725 4239 M14492 GO_TRACHEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_MORPHOGENESIS.html The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. 8/21 Gene Ontology BP GO:0060439 0.853233160620055 0.917240464172011 3725 3637.45454545455 3725 0.174603174603175 2574 0.366510304236902 0.330629222865274 1 0.0521938272604312 3725 2652 4245 2574 3291 4476 3200 4272 3478 4028 4071 4240 M14208 GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. 9/24 Gene Ontology BP GO:0002381 0.608586127811464 0.711217063032627 2610 3347.90909090909 3726 0.0895342327013534 1782 0.847293883868049 0.847293883868049 1 0.47598871652276 2609 4420 4203 3838 3726 2781 1782 1964 4302 3945 3257 4241 M13389 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 16/54 Gene Ontology BP GO:0030813 0.480171693276289 0.595787592699575 3470 3416.27272727273 3727 0.0577436257532595 1613 0.434345018179908 0.347972707620067 1 0.370807092117978 3469 4041 1613 4162 3537 4029 3664 1694 3738 3727 3905 4242 M14440 GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion. 6/14 Gene Ontology BP GO:0006851 0.844839588127941 0.911886672061017 3735 3363.63636363636 3731 0.17 1457 0.333684972848107 -0.316842838672101 -1 0.0507394098072558 3731 1457 4237 2512 4159 2847 4006 3024 3990 4017 3020 4243 M10205 GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 11/30 Gene Ontology BP GO:0035588 0.79726074333493 0.871804435069261 4280 3531.54545454545 3733 0.135043334071879 2136 0.33091755263645 -0.340333491748727 -1 0.0748400867411486 4278 3477 2136 4050 2924 2547 4418 3815 4492 2977 3733 4244 M13287 GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. 8/15 Gene Ontology BP GO:0032354 0.147859119791321 0.249186894080256 4045 3103 3733 0.0158730158730159 1274 1.08918898596586 1.08918898596586 1 2.49499462142605 3612 1408 4043 1323 4009 4554 3733 4621 1274 1515 4041 4245 M12152 GO_INNER_CELL_MASS_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_CELL_MASS_CELL_PROLIFERATION.html The proliferation of cells in the inner cell mass. 6/11 Gene Ontology BP GO:0001833 0.410640865008252 0.532900172584105 2750 3513.63636363636 3734 0.0514985438849912 1122 0.138496821085869 0.148534836051848 1 0.143705268360566 2747 4312 3857 4580 3542 3734 1122 3752 4614 3424 2966 4246 M13329 GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. 33/119 Gene Ontology BP GO:0002762 0.134760152113643 0.232772093104035 4040 3341.18181818182 3734 0.013072756684262 1470 1.29644110978073 1.29644110978073 1 3.11538075729456 3925 4036 2166 3507 1470 4037 3734 4335 2541 2590 4412 4247 M14095 GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. 6/21 Gene Ontology BP GO:1900273 0.875969603048932 0.936047610346649 4595 3677.45454545455 3734 0.188379863662944 2503 0.436735526094433 -0.403167540058092 -1 0.0475815773587952 4591 2983 4184 3648 3271 3949 3679 2503 3989 3921 3734 4248 M13503 GO_MEGAKARYOCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. 10/21 Gene Ontology BP GO:0035855 0.364015638212373 0.4839990286999 3915 3542.18181818182 3737 0.040308840312997 2126 0.189616737120128 -0.175094885924568 -1 0.226834341037979 3913 4306 3271 4101 2126 2966 3737 3576 3752 3759 3457 4249 M12454 GO_SPHINGOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. 7/13 Gene Ontology BP GO:0046519 0.159974190462302 0.258740097879113 4440 3599.90909090909 3740 0.0172812033084453 1630 0.351062105819976 -0.275087078769109 -1 0.782402245239995 4437 2943 3910 3209 1630 4481 3761 3740 3572 3492 4424 4250 M16377 GO_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that modulates the extent to which blood vessels can be pervaded by fluid. 11/38 Gene Ontology BP GO:0043114 0.466738071388703 0.580826820010117 3765 3438.81818181818 3742 0.0555555555555556 2079 0.364443335409272 0.351491104729291 1 0.326409935188533 3762 2079 2509 2345 4607 4270 3742 3248 2593 4484 4188 4251 M14155 GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. 38/102 Gene Ontology BP GO:0035305 0.751985672431077 0.832094727620946 4035 3646.90909090909 3743 0.119047619047619 2870 0.847293883868049 0.847293883868049 1 0.256739304671521 4033 3461 2870 3423 3834 4335 3743 3452 3230 3932 3803 4252 M10608 GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-10 production. 23/70 Gene Ontology BP GO:0032653 0.523497680432106 0.635617084269422 4260 3543 3744 0.06516883226939 1438 0.391241001446743 -0.266174091335521 -1 0.292271508366306 4045 4258 1438 4258 3167 3169 4410 3654 3771 3059 3744 4253 M13383 GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. 6/24 Gene Ontology BP GO:0031954 0.254550835381547 0.368495204931411 4405 3491.09090909091 3744 0.0289495290058922 1828 0.22769151223003 -0.216775374387408 -1 0.374723951240236 4404 4000 4065 3744 1926 2827 4468 1828 4249 3726 3165 4254 M13659 GO_TRNA_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_TRANSPORT.html The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 18/40 Gene Ontology BP GO:0051031 0.978161938897681 0.999999998379914 4065 3591 3745 0.293650793650794 2639 0.28499021409048 -0.268008325929721 -1 5.84195327438356e-10 4061 2639 3183 3371 4313 2960 4235 3290 3905 3799 3745 4255 M13640 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0034033 0.279464990482175 0.396563554648148 4485 3595.54545454545 3747 0.0322448108033995 2003 0.212674905503224 -0.237222331117918 -1 0.324273510826297 4484 2760 4110 3478 2003 2734 4515 4201 3723 3796 3747 4256 M14952 GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 8/17 Gene Ontology BP GO:0033866 0.279464990482175 0.396563554648148 4485 3646.54545454545 3748 0.0322448108033995 2004 0.212674905503224 -0.237222331117918 -1 0.324273510826297 4485 2761 4324 3479 2004 2735 4516 4200 3724 4136 3748 4257 M11453 GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 6/15 Gene Ontology BP GO:0060456 0.956599673940928 0.995524744274429 2830 3825.63636363636 3749 0.269282851963003 2828 0.293524684111305 0.264480461428658 1 0.00217033912505643 2828 4520 3749 4432 3388 3545 4347 4476 4595 3255 2947 4258 M14514 GO_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. 11/26 Gene Ontology BP GO:0030219 0.545830662844972 0.656892630271955 4015 3685.18181818182 3752 0.0692394175351567 2450 0.174118345850371 -0.175094885924568 -1 0.120622404897453 4014 4416 3212 4293 2450 2963 3752 3680 4322 4032 3403 4259 M11474 GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 5/18 Gene Ontology BP GO:0051571 0.9719939237659 0.999999998379914 3905 3831.72727272727 3753 0.300600646277509 2946 0.107645836750748 0.0203962817541017 1 1.10556701358406e-10 3901 4525 3753 4448 3693 3092 4532 2946 4622 3263 3374 4260 M16232 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html The directed movement of a protein to a specific location in the plasma membrane. 55/130 Gene Ontology BP GO:0090002 0.161385165508919 0.258740097879113 3755 3400.54545454545 3755 0.0158730158730159 1545 1.28458559501757 -0.995312132263088 -1 2.86291980036509 3755 3944 2586 3475 3687 3867 3974 4562 1545 1737 4274 4261 M10089 GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS.html A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. 13/26 Gene Ontology BP GO:0006278 0.89296361392824 0.948097429560671 3585 3668.90909090909 3757 0.183839475631742 2496 0.196965936511761 0.205050757069491 1 0.0173058781944725 3581 3757 3356 4014 3143 4499 2496 4057 4127 2953 4375 4262 M10379 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 7/25 Gene Ontology BP GO:1900153 0.916887921026626 0.965260512756181 4340 3812.18181818182 3757 0.220230193947805 3013 0.224845042880876 -0.217841831631718 -1 0.0131054930909426 4337 4235 3576 4066 3255 3680 3757 4592 3977 3013 3446 4263 M12681 GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/33 Gene Ontology BP GO:0051953 0.977212857477568 0.999999998379914 2270 3647 3757 0.314876306558377 2268 0.33909366206196 0.328685227816092 1 7.28690930556973e-10 2268 3967 3948 4208 3804 3757 3406 3352 4374 3552 3481 4264 M10723 GO_MEMBRANE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DISASSEMBLY.html The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. 28/57 Gene Ontology BP GO:0030397 0.992241128874358 0.999999998379914 4240 3729.72727272727 3759 0.357070277618703 2970 0.28163597389906 -0.249161397633954 -1 5.75237063637511e-10 4239 3423 2970 3964 3638 3193 4591 4046 4122 3082 3759 4265 M11583 GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 21/49 Gene Ontology BP GO:0051023 0.906168568811929 0.957955524816436 3580 3668.18181818182 3760 0.193550602344457 2249 0.317844590856224 -0.254695926043299 -1 0.0225065661788986 3576 3914 2249 4348 3179 4593 3791 3111 3760 3293 4536 4266 M11524 GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 9/20 Gene Ontology BP GO:0019370 0.673652498631537 0.764677175880671 3020 3667.81818181818 3761 0.105937191802934 1840 0.874649861425705 -0.874649861425705 -1 0.386855626319171 3018 4474 3761 4575 4561 2232 3667 4609 4330 3279 1840 4267 M14826 GO_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_SIGNALING.html A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. 11/20 Gene Ontology BP GO:0031929 0.161385165508919 0.258740097879113 4175 3338.72727272727 3762 0.0158730158730159 1490 0.90126246461125 0.90126246461125 1 2.0086183164449 4172 2396 2960 2129 3762 4407 4222 2582 1490 4107 4499 4268 M15947 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS.html Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. 9/37 Gene Ontology BP GO:1901522 0.386086746459241 0.506813899861537 3660 3587.90909090909 3762 0.0476190476190476 2184 0.33838986965178 -0.321758429016608 -1 0.379113764987198 3658 3762 4484 3916 4578 2184 3160 4277 2424 4387 2637 4269 M16275 GO_REGULATION_OF_CELL_PROJECTION_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_SIZE.html A process that modulates the size of a cell projection. 7/27 Gene Ontology BP GO:0032536 0.0765897756730953 0.158445571591463 4260 3003.90909090909 3763 0.00793650793650794 467 0.997293395573521 0.997293395573521 1 3.02890214682336 4258 1191 4540 903 1549 4133 4611 3171 467 4457 3763 4270 M11534 GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. 6/17 Gene Ontology BP GO:0072202 0.0405160776205433 0.105799878598956 4590 2613.63636363636 3764 0.00412743063983326 322 1.59728558834855 -1.38916827744188 -1 5.91457687037793 4589 669 3764 322 922 3922 4318 4338 1243 497 4166 4271 M12180 GO_WATER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSPORT.html The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/21 Gene Ontology BP GO:0006833 0.266394342454327 0.382813039930498 3670 3562.81818181818 3764 0.027769292839708 1173 0.352280226963803 0.311490389247111 1 0.557629037670638 3669 3687 1173 3764 2236 4216 4200 3934 4501 3429 4382 4272 M16550 GO_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PROCESS.html The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. 626/1538 Gene Ontology BP GO:0022402 0.824529293656915 0.895506318233697 4580 3630.81818181818 3764 0.159726896308103 1846 1.14704992553497 1.29599230773806 1 0.208693620525909 3390 4576 4578 4483 3486 1846 4185 3808 3764 2917 2906 4273 M16938 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. 17/42 Gene Ontology BP GO:0032108 0.943712354754118 0.986193216998283 3485 3855.90909090909 3765 0.23015873015873 3212 0.262302042240414 0.290320152305181 1 0.00601175395013217 3483 3212 3246 4021 3765 4489 4154 3439 3716 4635 4255 4274 M11541 GO_MAGNESIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSPORT.html The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 3/15 Gene Ontology BP GO:0015693 0.679064911973259 0.769938555871023 3770 3740.90909090909 3766 0.10743116247995 2764 0.266209088117235 -0.236572624988978 -1 0.114734502621331 4463 3125 3766 3769 2764 3529 3697 4449 4209 3284 4095 4275 M13289 GO_PROTEIN_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MANNOSYLATION.html The addition of a mannose residue to a protein acceptor molecule. 8/21 Gene Ontology BP GO:0035268 0.454144242926118 0.573454370385088 3220 3386.72727272727 3766 0.0587439308608858 1397 0.213613810812793 -0.201436920730857 -1 0.195819407066169 3219 4074 4045 4317 4573 1896 2364 3766 3907 3696 1397 4276 M16240 GO_PEPTIDYL_LYSINE_DIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_DIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. 7/15 Gene Ontology BP GO:0018027 0.785278192325745 0.862349906206979 3235 3504.81818181818 3766 0.142591833937795 2045 0.20643219823296 -0.213410437231591 -1 0.0503972607016548 3234 3766 4532 4369 3980 2045 3127 2610 4360 4448 2082 4277 M13491 GO_REGULATION_OF_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_CYCLE.html Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. 27/54 Gene Ontology BP GO:0046605 0.69920411299786 0.786054405968296 4550 3710.27272727273 3767 0.103458965051619 2672 0.273840001850046 -0.32194525019134 -1 0.108671917423056 4549 4010 2672 4156 2737 3767 3706 3019 4491 3754 3952 4278 M13533 GO_REGULATION_OF_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_DUPLICATION.html Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 20/42 Gene Ontology BP GO:0010824 0.843782688590043 0.911301005611437 4605 3734.54545454545 3767 0.15529969533149 2358 0.253598065603117 -0.291517371213912 -1 0.0388301570830749 4601 4296 2771 4335 3437 3798 3476 2358 4540 3767 3701 4279 M16116 GO_PEPTIDYL_METHIONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_METHIONINE_MODIFICATION.html The modification of peptidyl-methionine. 7/12 Gene Ontology BP GO:0018206 0.780909603696945 0.858575252182078 3770 3588.90909090909 3770 0.14086317581737 1872 0.216434561628695 -0.231956450473687 -1 0.054404363606379 3770 1872 4513 2831 2949 3513 4376 4119 3774 4422 3339 4280 M16367 GO_PHOSPHOLIPID_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_EFFLUX.html The directed movement of a phospholipid out of a cell or organelle. 5/18 Gene Ontology BP GO:0033700 0.201340458013431 0.308624544917914 3655 3561.18181818182 3770 0.022231214866852 1775 0.484146050456572 -0.339295049109619 -1 0.938293102710282 3655 2949 4553 3468 1775 3770 3870 2639 3843 4482 4169 4281 M13369 GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 10/20 Gene Ontology BP GO:0050857 0.0947839092412041 0.174977658176481 4405 3399.90909090909 3771 0.00901201790048196 865 0.450800910064251 -0.376217487148867 -1 1.29538205686914 4405 3609 1483 3771 4259 4075 4060 865 3075 3720 4077 4282 M10604 GO_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION.html The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. 272/718 Gene Ontology BP GO:0051301 0.879372141605041 0.937310572422453 3775 3488.81818181818 3775 0.174921561567136 1941 1.22624211850631 1.37429277528936 1 0.130871317635138 3775 4434 2364 4523 3795 1941 4232 3476 3852 2873 3112 4283 M15037 GO_ORGANELLE_INHERITANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INHERITANCE.html The partitioning of organelles between daughter cells at cell division. 9/16 Gene Ontology BP GO:0048308 0.998720994868181 0.999999998379914 3735 3856 3775 0.48632642039802 2863 0.231913501743762 -0.23988967908954 -1 4.42441856085938e-10 3734 2863 4338 3775 3919 3308 3744 3479 4500 4164 4592 4284 M16171 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 9/20 Gene Ontology BP GO:0090005 0.180249724278909 0.282736307373978 3785 3196.81818181818 3777 0.0196793360154845 1191 0.277512791742594 -0.242292346604955 -1 0.577910547745496 3783 3894 4522 3777 2344 1622 2514 1191 4286 4432 2800 4285 M12145 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. 19/48 Gene Ontology BP GO:0001916 0.721384030672554 0.806044265733481 3785 3722.72727272727 3781 0.109680264334402 2554 0.308573550902433 -0.253884334155682 -1 0.109681269624712 4173 3781 2554 3694 2782 3783 4609 4630 3802 3422 3720 4286 M11649 GO_TONGUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TONGUE_DEVELOPMENT.html The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. 4/29 Gene Ontology BP GO:0043586 0.725901671988758 0.809038395484434 4325 3726.09090909091 3782 0.121401133499573 1709 0.255026535575752 -0.380890394856004 -1 0.0890894166529374 4324 3970 3782 3634 3738 4135 1709 4299 3447 3306 4643 4287 M11937 GO_CYTOCHROME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 17/27 Gene Ontology BP GO:0017004 0.994879011097261 0.999999998379914 4110 3665.27272727273 3782 0.38090194512405 2831 0.199365060632689 -0.18576813072536 -1 3.55513817203936e-10 4110 3782 3355 4128 3935 2831 3220 3968 4312 3377 3300 4288 M14040 GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. 10/27 Gene Ontology BP GO:0016242 0.863228525251746 0.925842005715837 4575 3778.72727272727 3782 0.165446584128563 2411 0.256520305143092 -0.27668923375484 -1 0.0325833246010685 4571 3608 3126 3782 4452 3777 4369 2411 3585 3906 3979 4289 M10481 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. 5/19 Gene Ontology BP GO:2001028 0.987945623895701 0.999999998379914 4195 3873.63636363636 3784 0.357142857142857 3038 0.339741213083122 -0.257465658052429 -1 7.30420363317012e-10 4193 3555 3595 3784 4493 3762 3437 4048 4065 3038 4640 4290 M14783 GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. 11/31 Gene Ontology BP GO:0034394 0.796944161638877 0.871663543578164 3270 3752.45454545455 3787 0.134920634920635 2816 0.330073064968758 0.273629093371381 1 0.0747370412194928 3268 3787 2816 4183 4219 4485 3502 3645 3288 4096 3988 4291 M12963 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. 43/66 Gene Ontology BP GO:0042274 0.987252227668446 0.999999998379914 3855 3808.27272727273 3792 0.3273846807675 2633 0.1168583168053 -0.132487691167464 -1 1.35160731445405e-10 3852 4612 3493 4610 3792 2633 4233 3417 4628 3617 3004 4292 M13682 GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 3/19 Gene Ontology BP GO:0010919 0.756074840360796 0.836021787043386 4325 3574.72727272727 3792 0.131588312451239 2667 0.367662185803865 -0.368061495469274 -1 0.108551932602449 4321 3697 4116 3835 2907 3136 3085 2667 3962 3804 3792 4293 M13628 GO_DNA_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION.html The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. 16/31 Gene Ontology BP GO:0022616 0.994883598314871 0.999999998379914 3455 3735.45454545455 3793 0.380952380952381 3238 0.187157403022236 -0.24386182815889 -1 3.2291048201506e-10 3451 3816 3314 3802 4598 3238 3446 3918 4100 3793 3614 4294 M14993 GO_MEIOTIC_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE_PROCESS.html A process that is part of the meiotic cell cycle. 76/298 Gene Ontology BP GO:1903046 0.668374368491294 0.759858519320539 2365 3468 3794 0.0954708784651205 1580 0.275530441623903 -0.26221868755302 -1 0.124737797569119 2363 4443 1580 4599 3794 1868 4126 3736 4593 4150 2896 4295 M12475 GO_LONG_TERM_SYNAPTIC_DEPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_DEPRESSION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. 7/24 Gene Ontology BP GO:0060292 0.0113060737181318 0.044336233338924 4535 3580.90909090909 3795 0.00113640112998118 451 0.284062325132073 0.180895937956249 1 1.45913703985331 4535 3158 3915 3429 451 3795 4434 4120 3705 3498 4350 4296 M14109 GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. 78/183 Gene Ontology BP GO:0072331 0.362154312934017 0.481938227272181 3890 3579.90909090909 3795 0.0400538418331139 2123 1.05077947290469 1.05077947290469 1 1.26441572545742 3887 4441 2957 4467 2123 3022 4125 3987 3795 2851 3724 4297 M14310 GO_RHYTHMIC_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_BEHAVIOR.html The specific behavior of an organism that recur with measured regularity. 10/32 Gene Ontology BP GO:0007622 0.699840767336482 0.786389323025965 3135 3485.54545454545 3796 0.103631639263609 1592 0.849254971022537 0.849254971022537 1 0.336425844800993 3131 4266 2479 4081 3812 3501 1592 3796 4453 3976 3254 4298 M14608 GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. 28/84 Gene Ontology BP GO:0007157 0.019484732684303 0.0648273501378186 4395 3449.81818181818 3797 0.00178722487342042 654 1.51935086267539 -1.51935086267539 -1 6.8528323659904 4392 4131 654 4056 3133 3506 3960 4008 3789 2522 3797 4299 M14918 GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. 8/34 Gene Ontology BP GO:0022400 0.778760760271238 0.857024463128551 2950 3631.63636363636 3798 0.140024228690267 2578 0.291131020266766 -0.228253128010545 -1 0.0740481937391064 3530 2651 4317 2950 2946 4555 2578 4563 3931 4129 3798 4300 M15915 GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. 28/101 Gene Ontology BP GO:0002715 0.119068068548441 0.210603063722062 4370 3462.72727272727 3799 0.0114588342977207 1400 0.373091930002436 -0.28386513848463 -1 0.958105996069961 4367 2963 2014 3274 1400 3960 4597 3799 3864 4376 3476 4301 M11748 GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. 10/22 Gene Ontology BP GO:0006206 0.843143985346872 0.911035030012922 3370 3638.45454545455 3802 0.154986313245686 1939 0.229619091737028 -0.148848851236577 -1 0.0352690652814541 3368 4024 2997 3856 3802 4529 1939 3783 4283 3334 4108 4302 M14763 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE.html Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. 3/43 Gene Ontology BP GO:0050884 0.275742742869669 0.392721949430635 4525 3314.18181818182 3802 0.0317460317460317 1946 0.254094702176265 -0.259790056499591 -1 0.391505397900285 4524 2084 4290 2016 2127 3802 4124 3321 1946 4093 4129 4303 M12223 GO_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 40/79 Gene Ontology BP GO:0032204 0.908247739469006 0.959683411241431 3900 3614.36363636364 3803 0.195191723570399 2044 0.247909332702274 -0.220689353163326 -1 0.0168179692868712 3896 4610 2944 4594 3803 2044 4338 3588 4017 3439 2485 4304 M13037 GO_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_CYCLE.html The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. 27/66 Gene Ontology BP GO:0007098 0.949776431494504 0.990746342716015 4165 3599.09090909091 3804 0.238095238095238 2225 1.08125035744157 -0.862559895960135 -1 0.0165709882710949 4164 3804 2225 3331 3898 3083 4586 4330 3730 2495 3944 4305 M13030 GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 3/21 Gene Ontology BP GO:0042423 0.985970995808246 0.999999998379914 3805 3822.90909090909 3805 0.347316423751591 2870 0.46896628455716 0.395417675398988 1 1.07554540323185e-09 3805 2870 3997 3725 3620 4513 4257 4205 4409 3629 3022 4306 M13860 GO_REGULATION_OF_MRNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_POLYADENYLATION.html Any process that modulates the frequency, rate or extent of mRNA polyadenylation. 8/13 Gene Ontology BP GO:1900363 0.640993586463961 0.737214075291596 2930 3214.18181818182 3806 0.0973690501961571 1417 0.197920547963438 -0.323502248556056 -1 0.0994734160088437 2930 4269 4146 4321 3806 1417 1695 2030 4425 3857 2460 4307 M13701 GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of B cell apoptotic process. 13/27 Gene Ontology BP GO:0002902 0.197234535674437 0.30464402832216 3810 3372.36363636364 3807 0.0197739415212155 1712 0.359755171416913 -0.279494648156594 -1 0.704917746374841 4287 3214 2269 3052 1712 4324 4044 2209 3807 3809 4369 4308 M13959 GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 10/23 Gene Ontology BP GO:1900103 0.591189257097291 0.698090468133958 4385 3632.27272727273 3807 0.0780999353302419 2544 0.24986911728031 -0.201754139933144 -1 0.148043771749216 4384 3993 2810 3807 2544 3045 4202 3114 4462 3892 3702 4309 M13896 GO_MULTI_ORGANISM_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_LOCALIZATION.html A localization which involves another organism. 38/115 Gene Ontology BP GO:1902579 0.963737517038277 0.999999998379914 3545 3699.72727272727 3809 0.260323886216713 2344 0.247601083291632 -0.263919768118549 -1 4.84339122197828e-10 3544 4397 3072 4458 3809 2344 4067 3555 4405 3867 3179 4310 M15208 GO__DE_NOVO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_PROTEIN_FOLDING.html The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. 13/33 Gene Ontology BP GO:0006458 0.554355437134893 0.665577718429589 2530 3574.81818181818 3809 0.0708413510136265 1209 0.196136375970222 -0.204952818942012 -1 0.131628716851845 2529 4562 2955 4551 4603 1209 3809 3767 4625 4212 2501 4311 M10400 GO_PIGMENT_GRANULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_LOCALIZATION.html Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. 16/29 Gene Ontology BP GO:0051875 0.768795973707133 0.847866913520717 3910 3420.63636363636 3813 0.124650678709431 1625 0.266154367587895 -0.209288059768323 -1 0.0724089485712572 3909 3813 3208 3831 4240 1625 4163 4047 3485 3017 2289 4312 M14617 GO_IRON_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_IMPORT.html The directed movement of iron ions into a cell or organelle. 8/16 Gene Ontology BP GO:0097286 0.918986889777588 0.966664279392239 4510 3864.27272727273 3813 0.222222222222222 3271 0.355403904308978 0.278342857370214 1 0.0198639194219895 4510 3510 4259 3271 4268 3813 3688 3381 3672 4056 4079 4313 M11926 GO_INTRA_S_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_S_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. 6/13 Gene Ontology BP GO:0031573 0.995113049815651 0.999999998379914 2910 3785.81818181818 3814 0.412640778951227 2910 0.132371528876667 0.176965829691962 1 1.76592304082713e-10 2910 4523 3826 4398 4138 3530 3024 3644 4464 3373 3814 4314 M13716 GO_FATTY_ACID_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_TRANSPORT.html The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/31 Gene Ontology BP GO:1901571 0.97805785598086 0.999999998379914 3420 3583.27272727273 3814 0.317460317460317 2183 0.500001226222834 -0.410061940439521 -1 1.158431296495e-09 3420 2183 4120 2675 4466 3000 4058 4091 3949 3814 3640 4315 M11077 GO_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 93/281 Gene Ontology BP GO:0006413 0.964580988386728 0.999999998379914 3605 3834.81818181818 3815 0.261904761904762 2928 0.167883918464133 0.134468327352482 1 2.71436243683922e-10 3605 4538 3511 4526 3393 4106 2928 4378 3815 3160 4223 4316 M13717 GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 9/34 Gene Ontology BP GO:0002323 0.796116976607324 0.871374616310185 2970 3667.54545454545 3815 0.147021456897377 2789 0.243843645011584 0.264913471512345 1 0.0553457446505132 2967 3924 4121 3749 2982 4003 2789 3956 4375 3815 3662 4317 M12165 GO_HYPOTHALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPOTHALAMUS_DEVELOPMENT.html The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. 8/35 Gene Ontology BP GO:0021854 0.0293044763333802 0.0847202264108869 4390 3205.72727272727 3816 0.00296982429353978 768 0.743128926420273 -0.743128926420273 -1 3.02392771885962 4390 3073 3863 1766 768 3816 3967 2328 3842 3427 4023 4318 M10551 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION.html The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. 68/151 Gene Ontology BP GO:0006353 0.953087083645644 0.993084230109229 3605 3707.45454545455 3817 0.242803839910996 2275 0.795460638453866 -0.635897419203641 -1 0.00910032387047925 3602 4389 3479 4403 4512 2275 3817 4018 3944 3045 3298 4319 M15449 GO_KERATINIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINIZATION.html The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. 13/66 Gene Ontology BP GO:0031424 0.371527677899287 0.492576530121756 3820 3571.27272727273 3817 0.0413449203226292 1266 1.16751959882986 1.16751959882986 1 1.36286755433366 3417 4466 1266 4492 3514 3817 3776 4247 4508 1961 3820 4320 M12643 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. 8/15 Gene Ontology BP GO:0071459 0.52340095663996 0.635617084269422 3715 3431 3818 0.0714285714285714 1514 1.73041933125535 1.73041933125535 1 1.29268728589023 3712 2866 3944 2117 3818 4373 4040 4526 2725 1514 4106 4321 M15712 GO_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that modulates the frequency, rate, or extent of receptor recycling. 11/26 Gene Ontology BP GO:0001919 0.983912657982325 0.999999998379914 4240 3738.09090909091 3819 0.313005725305587 2199 0.247038687566919 0.187489643632136 1 4.82837116087671e-10 4238 3819 2199 3750 4250 2866 3251 4274 4602 4335 3535 4322 M14491 GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE.html The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. 2/15 Gene Ontology BP GO:0007342 0.0692024938784801 0.154030287189733 3680 3047.2 3821 0.00793650793650794 15 1.51132003020046 -1.06615318685725 -1 4.66047636303608 3677 321 4244 NA 4307 4040 3448 2428 15 4027 3965 4323 M16322 GO_REGULATION_OF_MYOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of myoblast proliferation. 6/25 Gene Ontology BP GO:2000291 0.17313505449836 0.274047850792458 4220 3200.72727272727 3822 0.0188318137014924 1458 0.41959860981167 -0.43176355944015 -1 0.895388924928554 4217 1458 4550 1634 1687 4159 3822 2307 2546 4472 4356 4324 M16958 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 31/73 Gene Ontology BP GO:0090502 0.912207156538424 0.962148529715562 4450 3620.72727272727 3822 0.198412698412698 2314 1.35593454827845 1.35593454827845 1 0.0862511747361456 4446 4130 3075 4201 3429 2314 4294 3822 3583 2566 3968 4325 M13742 GO_MITOTIC_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. 39/105 Gene Ontology BP GO:0007052 0.966053788858359 0.999999998379914 4540 3698.72727272727 3823 0.264749085302098 2779 0.768455391592508 -0.768455391592508 -1 1.8753994009168e-09 4539 3623 2779 3848 4427 3299 3951 2802 3915 3823 3680 4326 M16264 GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that activates or increases the frequency, rate or extent of receptor recycling. 8/17 Gene Ontology BP GO:0001921 0.991326348152126 0.999999998379914 3200 3816 3823 0.377957298817856 2824 0.268993132476763 -0.372031166310315 -1 5.41471470778977e-10 3198 3823 4537 3441 4136 2824 3195 4602 4542 4455 3223 4327 M12371 GO_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BEHAVIOR.html Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 23/91 Gene Ontology BP GO:0050795 0.63389956273523 0.731410454716618 4155 3417.90909090909 3824 0.0873015873015873 1555 1.51935086267539 -1.51935086267539 -1 0.783410268632111 4153 3980 1555 3240 3204 4163 4225 3824 2977 2389 3887 4328 M14807 GO_CARDIOLIPIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOLIPIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. 6/15 Gene Ontology BP GO:0032048 0.906017277583582 0.957955524816436 3620 3615.45454545455 3824 0.210586040139039 2404 0.308756401727704 -0.280269449209003 -1 0.021863031767555 3616 3447 4296 3824 3225 2404 3897 4321 4020 4101 2619 4329 M12411 GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. 8/17 Gene Ontology BP GO:0050655 0.721499023990598 0.806044265733481 4120 3538.09090909091 3825 0.12 1189 0.407498442054649 -0.338564527161881 -1 0.14484373784285 4118 1189 3904 2397 3825 3459 4352 4251 3306 3480 4638 4330 M15000 GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 16/34 Gene Ontology BP GO:0050858 0.538692208256659 0.651107178529143 2995 3412.90909090909 3825 0.0679188862441087 1283 0.348063035267172 0.356648770060076 1 0.24620039366257 2994 4262 1601 4435 4574 3870 1283 3276 3269 4153 3825 4331 M11875 GO_MEMBRANE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DOCKING.html The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. 33/78 Gene Ontology BP GO:0022406 0.73122366167779 0.81336462226817 3830 3448 3826 0.112585628914365 1545 0.481449101090274 -0.481449101090274 -1 0.163953738344654 3826 4092 3130 4373 4154 1545 3986 3115 3853 3360 2494 4332 M15817 GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. 14/49 Gene Ontology BP GO:1901186 0.744744952045939 0.82605131685363 3595 3649.09090909091 3826 0.116739973084467 1669 0.743128926420273 -0.743128926420273 -1 0.234106091941051 3593 3815 1669 3826 4478 4122 2992 2160 4555 4359 4571 4333 M13562 GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 5/12 Gene Ontology BP GO:0060394 0.806908404939689 0.880280950219684 3820 3825.27272727273 3827 0.151647513645464 2335 0.325835753309474 -0.152006797820836 -1 0.068493395314205 3818 4155 4097 3827 3763 4282 4106 2335 3665 3773 4257 4334 M13749 GO_POSITIVE_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_URINE_VOLUME.html Any process that increases the amount of urine excreted from the body over a unit of time. 9/17 Gene Ontology BP GO:0035810 0.162748455205736 0.260206982617159 4130 3392.18181818182 3827 0.0176062388426088 1610 0.792904243146179 -0.792904243146179 -1 1.75973387254549 4220 1610 4127 1984 1643 4356 4128 3598 3459 3827 4362 4335 M12953 GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION.html Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 10/19 Gene Ontology BP GO:0051127 0.875384934858783 0.935816355965542 3740 3757.54545454545 3828 0.172478776824965 2437 0.253744715313204 0.223555788541277 1 0.0277484017893985 3740 4514 3055 4082 3933 4527 3176 2437 3828 3613 4428 4336 M14674 GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. 96/234 Gene Ontology BP GO:1901796 0.664927543746456 0.758975695142582 4600 3726.18181818182 3828 0.094620214840693 2569 1.60640719314898 1.60640719314898 1 0.73032917353465 4596 4598 3256 4522 2672 2569 4085 4639 3345 2878 3828 4337 M12862 GO_PROTEIN_O_LINKED_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_MANNOSYLATION.html The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. 8/16 Gene Ontology BP GO:0035269 0.454144242926118 0.573454370385088 3220 3375.45454545455 3832 0.0587439308608858 1396 0.213613810812793 -0.201436920730857 -1 0.195819407066169 3218 4073 3970 4316 4572 1895 2363 3832 3906 3589 1396 4338 M15932 GO_RNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 148/362 Gene Ontology BP GO:0006401 0.987994855010154 0.999999998379914 3510 3839.18181818182 3832 0.331044795015986 2911 1.35593454827845 1.35593454827845 1 3.44439653968877e-09 4010 4594 3509 4612 3561 3333 3510 4134 4225 2911 3832 4339 M11966 GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 9/24 Gene Ontology BP GO:0045723 0.982658470084167 0.999999998379914 4585 3829 3835 0.333333333333333 2988 0.649810243057386 -0.649810243057386 -1 1.55853045933442e-09 4582 3996 3835 3467 4362 2988 4018 3721 3974 3382 3794 4340 M14634 GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. 4/19 Gene Ontology BP GO:0021527 0.201255648085212 0.30861876712258 3835 3584.72727272727 3835 0.0222208324030124 1774 0.513915232992934 -0.453469024322717 -1 0.996002749331195 3835 1951 4264 2933 1774 3815 4581 4434 3663 4062 4120 4341 M12024 GO_SOMATIC_CELL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_CELL_DNA_RECOMBINATION.html Recombination occurring within or between DNA molecules in somatic cells. 16/36 Gene Ontology BP GO:0016444 0.959426048317801 0.997450770788076 4215 3817.81818181818 3836 0.252730893691464 3153 0.847293883868049 0.847293883868049 1 0.00356523881241328 4211 4461 3153 4194 3347 3830 3889 3836 3780 3396 3899 4342 M16225 GO_EPITHELIAL_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MATURATION.html The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 14/25 Gene Ontology BP GO:0002070 0.96855221189793 0.999999998379914 3265 3687.72727272727 3836 0.26984126984127 2035 1.05077947290469 1.05077947290469 1 2.62941028069691e-09 3261 4339 2928 4165 4425 3902 3550 4405 3836 2035 3719 4343 M11511 GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 24/83 Gene Ontology BP GO:0048260 0.298735036746822 0.413174493778819 3485 3575.90909090909 3837 0.0317460317460317 1908 0.384887139321848 -0.248650048125055 -1 0.560816573317227 3481 4324 1908 4532 3837 4341 4356 2570 2069 3276 4641 4344 M12535 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. 33/88 Gene Ontology BP GO:0032735 0.451654139858776 0.570775767927136 3735 3621.18181818182 3837 0.0531576206884515 1792 0.975157604060794 0.975157604060794 1 0.901451754045295 3735 4286 1792 4338 2296 4387 3440 4496 3837 2589 4637 4345 M12991 GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. 24/68 Gene Ontology BP GO:0001914 0.917028671498496 0.965260512756181 4110 3745.27272727273 3838 0.202518290311381 2522 0.300733177098101 -0.232908485806042 -1 0.0175287679799631 4106 3882 2522 4010 3200 4635 3643 3431 3838 3622 4309 4346 M11336 GO_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION.html The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 23/52 Gene Ontology BP GO:0006306 0.949699151114831 0.990746342716015 3825 3637.36363636364 3840 0.237988734046236 2561 0.215071921112451 -0.19429824290228 -1 0.00329614145735036 3824 3840 3360 3966 3946 2853 3988 4288 4158 3227 2561 4347 M12920 GO_APOPTOTIC_NUCLEAR_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_NUCLEAR_CHANGES.html Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. 13/32 Gene Ontology BP GO:0030262 0.970732606451296 0.999999998379914 3910 3644.63636363636 3840 0.274595295260259 2574 0.250077860397991 -0.302262017944061 -1 4.9095392061072e-10 3907 4511 2719 4538 3840 2574 4028 2837 4427 3604 3106 4348 M13138 GO_POSITIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of exocytosis. 46/117 Gene Ontology BP GO:0045921 0.542814474967003 0.654960396900154 3690 3887.36363636364 3840 0.0686791719703438 2444 0.261487052586884 0.23361638358726 1 0.182417872899041 3690 4448 3229 4585 2444 4454 4556 3308 3840 3657 4550 4349 M13754 GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION.html The directed movement of the nucleus to a specific location within a cell. 8/29 Gene Ontology BP GO:0040023 0.406531850111258 0.528719154080272 3800 3737.54545454545 3842 0.0508393138211412 1617 0.221007431273384 -0.210482563196806 -1 0.232188602712011 3799 3579 4129 3842 4248 3917 3367 1617 4603 3828 4184 4350 M11484 GO_MEMBRANE_RAFT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_RAFT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. 8/25 Gene Ontology BP GO:0031579 0.560658862798758 0.669531661516109 4485 3866.54545454545 3846 0.0789564045845112 2559 0.146426424600698 -0.148642731264603 -1 0.0968382282790435 4482 4373 3756 4390 2559 3344 4485 3415 4615 3267 3846 4351 M15928 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 13/27 Gene Ontology BP GO:0030949 0.511341893117069 0.627050688219243 4565 3683.09090909091 3847 0.0630255744515503 1424 0.362152265181509 0.257035036110648 1 0.278641956024613 4564 4070 1424 3914 3793 4404 3358 2941 3847 4381 3818 4352 M13192 GO_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE.html Any process that modulates the frequency or rate of heart contraction. 58/161 Gene Ontology BP GO:0002027 0.0314852001353949 0.0892373442861315 4265 3184.09090909091 3848 0.00290409448370592 719 1.57972387808866 1.65818934835506 1 6.29291053198671 2299 4190 719 4263 3901 4265 2951 4450 2310 1829 3848 4353 M14587 GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 8/26 Gene Ontology BP GO:0032924 0.509689152586484 0.626386113144268 4030 3684.90909090909 3848 0.0687910312424573 2447 0.340040725017623 -0.263127516456793 -1 0.262223635671437 4027 2982 4254 3063 2447 4236 3460 3848 3695 4048 4474 4354 M12103 GO_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_EFFLUX.html The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 9/31 Gene Ontology BP GO:0033344 0.975368714677481 0.999999998379914 3935 3810.36363636364 3850 0.30952380952381 3124 0.386378125253097 -0.32774838592344 -1 8.54974878865497e-10 3932 3644 3850 4004 3678 3124 4014 3710 3930 3413 4615 4355 M12109 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 7/21 Gene Ontology BP GO:0060213 0.916887921026626 0.965260512756181 4340 3874 3851 0.220230193947805 3256 0.224845042880876 -0.217841831631718 -1 0.0131054930909426 4338 4236 3851 4067 3256 3681 3758 4587 3978 3415 3447 4356 M15403 GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. 8/17 Gene Ontology BP GO:0033235 0.961389229168377 0.998597358171985 4400 3854.63636363636 3851 0.277777777777778 3291 0.207134129067603 0.175592786318684 1 0.000479285828976367 3727 3822 4398 3291 3447 4013 3312 4397 3851 4261 3882 4357 M12624 GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE.html A cascade of processes induced by the detection of DNA damage within a cell. 60/128 Gene Ontology BP GO:0042770 0.894071956619757 0.948840250190979 3855 3508.09090909091 3853 0.184611406391608 1995 1.05077947290469 1.05077947290469 1 0.0909672531546732 3853 4391 3035 4564 4210 1995 3362 3980 4015 2793 2391 4358 M13854 GO_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_RECOMBINATION.html Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. 112/230 Gene Ontology BP GO:0006310 0.982294230119317 0.999999998379914 2535 3775.81818181818 3854 0.306992857832674 2532 0.847293883868049 0.847293883868049 1 2.08595558388543e-09 2532 4597 3375 4609 4641 2559 3615 3989 4563 3854 3200 4359 M10314 GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 6/18 Gene Ontology BP GO:0043517 0.883774206100005 0.941138449294111 4055 3741.45454545455 3859 0.193637630911923 3001 0.270550183857456 -0.218590103043403 -1 0.0270568802731946 4051 4270 3565 4012 3180 3420 3950 4228 3620 3001 3859 4360 M13865 GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. 7/15 Gene Ontology BP GO:0051988 0.886818440775095 0.943399907413338 4480 3805.63636363636 3859 0.195775003922918 3147 0.269457831319591 -0.214562789619571 -1 0.0258815419656823 4477 3407 4148 3147 3186 3800 3484 4430 4063 3859 3861 4361 M14015 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. 11/42 Gene Ontology BP GO:0042534 0.990052160566322 0.999999998379914 4050 3785.36363636364 3859 0.342379500859268 2524 0.310290746072419 -0.227427718044598 -1 6.51766171164975e-10 4048 3852 2524 3841 4090 3859 3698 3070 4180 3901 4576 4362 M12573 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 149/314 Gene Ontology BP GO:0010948 0.161356930514389 0.258740097879113 4380 3370.72727272727 3860 0.0158700037203746 1577 1.30931078930951 1.42798520168239 1 2.91802414575492 4378 4436 2765 3985 1577 2403 4533 4254 2789 2098 3860 4363 M15153 GO_REGULATION_OF_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_MOVEMENT.html Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. 7/27 Gene Ontology BP GO:0003352 0.765732552532725 0.844889791209468 3550 3701 3860 0.135089450031595 2472 0.196886402324539 -0.157083187114355 -1 0.0547058364490649 3681 3899 4362 3860 2925 2472 3935 3549 4288 4194 3546 4364 M14820 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. 15/39 Gene Ontology BP GO:0006360 0.97530599069028 0.999999998379914 3760 3923.72727272727 3861 0.285714285714286 3275 0.195230403494994 0.166758120127399 1 3.44471271872723e-10 3760 4227 3374 3847 4349 4361 3509 3275 3861 4105 4493 4365 M11364 GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. 10/25 Gene Ontology BP GO:0050774 0.986831624970353 0.999999998379914 4365 3635.27272727273 3863 0.325396825396825 2609 0.312869518610687 -0.267405474640908 -1 6.58653371652071e-10 4364 2939 2609 3900 3906 4330 3322 3863 3970 3237 3548 4366 M12694 GO_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACETYLATION.html The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic 76/148 Gene Ontology BP GO:0006473 0.466738071388703 0.580826820010117 4615 3713.09090909091 3867 0.0555555555555556 2551 1.26299627138321 1.47370605752984 1 1.13118965608625 4612 4540 3343 4332 4278 2551 4630 3867 2595 2845 3251 4367 M11316 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. 9/16 Gene Ontology BP GO:0055022 0.998228940920146 0.999999998379914 3870 3892.72727272727 3868 0.469331505113342 3221 0.311975534402736 0.259271901834891 1 6.56265782835651e-10 3868 3402 3729 3555 4295 4413 3239 4257 4478 3221 4363 4368 M12202 GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. 7/10 Gene Ontology BP GO:0006995 0.544439701582726 0.656068916285646 4560 3738.90909090909 3868 0.0756113873085177 2517 0.240753622614682 0.153717667459408 1 0.167282716018099 4557 3824 3868 3640 2517 4583 3998 2766 3971 3435 3969 4369 M14867 GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). 9/28 Gene Ontology BP GO:0034369 0.214139132665174 0.322775948981753 3025 3507.63636363636 3868 0.0238095238095238 1740 0.483922949675687 0.359381959782188 1 0.902095158724525 4515 3024 4308 3023 2713 2845 4134 4295 1740 4119 3868 4370 M16168 GO_PROTEIN_LIPID_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_REMODELING.html The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. 9/28 Gene Ontology BP GO:0034368 0.214139132665174 0.322775948981753 3025 3555.63636363636 3869 0.0238095238095238 1741 0.483922949675687 0.359381959782188 1 0.902095158724525 4516 3025 4521 3024 2714 2846 4135 4290 1741 4431 3869 4371 M14987 GO_PRE_MIRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MIRNA_PROCESSING.html Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. 4/13 Gene Ontology BP GO:0031054 0.601711610006644 0.704779769238357 4510 3687.09090909091 3873 0.087947654170334 2609 0.254496379218844 -0.202078101103665 -1 0.146784345889667 4507 2609 4332 2876 2624 4054 3873 3344 3832 4149 4358 4372 M16505 GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 18/41 Gene Ontology BP GO:0043536 0.466738071388703 0.580826820010117 4640 3595.90909090909 3875 0.0555555555555556 2582 0.323617513488083 -0.306130760636575 -1 0.289844706523911 4638 2966 2871 3351 2582 4073 4156 3923 2602 4518 3875 4373 M16750 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. 20/47 Gene Ontology BP GO:0002483 0.929781992756842 0.974927234049236 3880 3666.63636363636 3876 0.214526239064843 2500 0.25691939376333 -0.22240566656923 -1 0.0107545663114046 3876 4367 2500 4396 3236 2947 3929 2670 4489 4580 3343 4374 M16761 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 15/43 Gene Ontology BP GO:1902175 0.902157871246138 0.954802597719585 3915 3729.54545454545 3876 0.19047619047619 2391 0.274155015258381 -0.266308797318701 -1 0.0209028596345673 3912 2501 3224 2391 3768 4596 3876 4001 3539 4585 4632 4375 M12464 GO_L_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_IMPORT.html The directed movement of L-enantiomer amino acids into a cell or organelle. 5/23 Gene Ontology BP GO:0043092 0.297508185353055 0.413174493778819 3885 3574.36363636364 3878 0.0346959532912225 2042 0.529742609134116 0.454170462287256 1 0.771884546061494 3883 3124 3912 2955 2042 3878 4508 4261 3079 3495 4181 4376 M13929 GO_PURINE_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOTIDE_TRANSPORT.html The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. 9/18 Gene Ontology BP GO:0015865 0.794344583148707 0.869867460804585 4295 3779.45454545455 3878 0.146282831480415 2781 0.277559577757386 0.20823433501499 1 0.063790420424533 4295 3791 4159 3896 2976 4059 3531 2781 3702 3878 4506 4377 M13938 GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. 11/18 Gene Ontology BP GO:0007004 0.608163433707587 0.710902019814785 4075 3757.36363636364 3881 0.0816472263590779 2579 0.215116993656336 -0.187533645861077 -1 0.12100451809072 4075 3546 3342 3778 2579 4422 2959 4289 3897 3881 4563 4378 M11801 GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle. 22/37 Gene Ontology BP GO:1900087 0.947255901301986 0.989005880311473 3045 3649 3882 0.234695990449132 2797 0.989745402399581 -0.989745402399581 -1 0.0180373961382556 3041 4066 2797 4132 3303 4534 2814 3882 4237 3344 3989 4379 M12284 GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. 8/25 Gene Ontology BP GO:1901798 0.965428386966392 0.999999998379914 3965 3902.45454545455 3883 0.285714285714286 3142 0.220423049124285 -0.176147686438079 -1 4.11753980477114e-10 3961 4571 3883 4444 4023 3142 3691 4271 3879 3456 3606 4380 M13734 GO_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_BURST.html A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 8/26 Gene Ontology BP GO:0045730 0.0822779092740835 0.158445571591463 3500 3525.54545454545 3885 0.00854931175851625 1265 0.318095158965714 0.256936105846503 1 0.966093943910176 3500 3693 4124 3885 1265 4185 1707 4258 4287 3821 4056 4381 M11276 GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. 9/32 Gene Ontology BP GO:1901385 0.783184818729923 0.86046547878917 4315 3849.72727272727 3886 0.141759571246445 2954 0.338294890604743 0.361490782207243 1 0.0838095126862546 4311 3613 3721 3886 2954 3915 4161 4443 3626 3209 4508 4382 M13712 GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT.html A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. 59/132 Gene Ontology BP GO:0044774 0.96855221189793 0.999999998379914 4550 3863.09090909091 3887 0.26984126984127 2481 1.18847832685675 -1.3261771808088 -1 2.99716649026479e-09 4548 4607 2807 4471 3887 3140 4637 4422 3839 2481 3655 4383 M15293 GO_NUCLEUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. 79/272 Gene Ontology BP GO:0006997 0.897242646818503 0.951118175611486 4155 3719.54545454545 3888 0.186860965155626 2807 0.290132142681196 -0.281061990906473 -1 0.023970224444214 4154 4087 3081 4161 3154 2807 3512 3806 4035 4230 3888 4384 M16816 GO_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_SPLICING.html Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 59/150 Gene Ontology BP GO:0043484 0.541889093992704 0.654524210043737 3075 3500.09090909091 3888 0.0685079594626426 1184 0.227896993273804 -0.22383293774796 -1 0.159235152356897 3072 4360 3410 4470 3322 1184 3888 4078 4218 4599 1900 4385 M15058 GO_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. 7/19 Gene Ontology BP GO:0046339 0.982658470084167 0.999999998379914 3630 3957.27272727273 3889 0.333333333333333 3493 0.323399504520925 0.279137499350363 1 6.86776101754825e-10 3626 3727 4342 3889 3839 3877 3493 4184 3976 4168 4409 4386 M14068 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS.html The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. 16/36 Gene Ontology BP GO:0002562 0.959426048317801 0.997450770788076 4215 3867.09090909091 3890 0.252730893691464 3154 0.847293883868049 0.847293883868049 1 0.00356523881241328 4212 4462 3154 4195 3348 3831 3890 3852 3781 3913 3900 4387 M13906 GO_TRACHEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_DEVELOPMENT.html The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. 13/31 Gene Ontology BP GO:0060438 0.652984842077343 0.748594721423482 3895 3834.81818181818 3891 0.0917330841425001 2643 0.266341091547914 0.259166310178441 1 0.127134841982496 3891 4147 2742 3448 2643 4432 3861 4411 4241 3869 4498 4388 M15420 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. 7/16 Gene Ontology BP GO:1903203 0.96908319439447 0.999999998379914 3895 3874.36363636364 3892 0.293650793650794 3259 0.316971552556552 -0.275839134359447 -1 6.6960878930555e-10 3506 3259 4402 3740 3939 4333 3751 3893 3892 4266 3637 4389 M14081 GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). 7/24 Gene Ontology BP GO:0007191 0.984316631190892 0.999999998379914 4235 3603.81818181818 3893 0.34 2277 0.430322692288442 -0.370139050325541 -1 9.72338872393338e-10 3452 2277 4181 3031 4232 3218 3893 3950 4234 3916 3258 4390 M13970 GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of T cell cytokine production. 24/76 Gene Ontology BP GO:0002724 0.67758502177107 0.768636026406811 4420 3844.27272727273 3894 0.0977841061155926 2692 0.259497317999638 -0.241918715772578 -1 0.112566078791703 4417 4065 2750 4295 2692 3812 4564 3792 4254 3894 3752 4391 M12696 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 6/15 Gene Ontology BP GO:0032968 0.781272392934155 0.858770767138561 3905 3562.81818181818 3901 0.141005545403019 2073 0.17016163651786 -0.193881669703846 -1 0.0427090364987847 3902 3901 3952 3905 3843 2860 4203 2550 4444 3558 2073 4392 M14788 GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 11/27 Gene Ontology BP GO:0090322 0.199268649250204 0.306460529469592 4550 3061.36363636364 3901 0.02 299 0.545918948427206 -0.48665527547032 -1 1.06434380431803 4550 299 1770 1304 3415 3901 4283 4053 1987 4097 4016 4393 M14184 GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR.html Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. 38/91 Gene Ontology BP GO:0000731 0.997597858377938 0.999999998379914 3595 3850 3902 0.422073510808494 3053 0.759980613502947 -0.759980613502947 -1 1.85276557225595e-09 3594 4452 3123 4114 3902 3053 4580 3889 4466 3940 3237 4394 M16564 GO_RNA_INTERFERENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_INTERFERENCE.html The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. 4/12 Gene Ontology BP GO:0016246 0.937761775715608 0.981963898206489 3760 3814.54545454545 3902 0.242459738840445 2812 0.191112822871924 -0.117566692641105 -1 0.00573416623359848 3756 3413 4582 3285 3320 4092 2812 4162 4104 4532 3902 4395 M11278 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY.html Any process that increases the activity of triglyceride lipase. 3/15 Gene Ontology BP GO:0061365 0.996724509389249 0.999999998379914 3610 3868.18181818182 3903 0.43567714968929 3210 0.152498520696 -0.0816395083631414 -1 2.30346028308035e-10 3606 3903 3722 3739 4325 4233 4110 3335 4320 3210 4047 4396 M14667 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 5/14 Gene Ontology BP GO:0032740 0.0765897756730953 0.158445571591463 4050 2840.90909090909 3903 0.00793650793650794 94 0.642022895211415 -0.532259607223537 -1 1.94990213931421 4049 158 4269 283 4377 2507 4458 3903 94 4070 3082 4397 M15645 GO_PROTEIN_K48_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. 28/61 Gene Ontology BP GO:0070936 0.706554651396122 0.792782321515755 3425 3569 3903 0.105473142353385 1602 1.48034281358945 1.48034281358945 1 0.56666761328628 3422 4548 2760 4494 3464 4143 1602 4000 3903 2523 4400 4398 M11188 GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 8/17 Gene Ontology BP GO:0009129 0.978302537028173 0.999999998379914 3905 3941.54545454545 3904 0.318225277009255 3185 0.181868127644523 -0.17006812861615 -1 3.08784265213389e-10 3904 4473 3704 4446 3515 3279 4260 4440 4631 3185 3520 4399 M13946 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. 4/13 Gene Ontology BP GO:0040015 0.0163542385743853 0.057520768137511 4095 3204.72727272727 3904 0.00164758576752511 558 0.858982002181133 0.858982002181133 1 4.04365766233148 4092 2187 4162 1982 558 3904 4324 4480 1648 3884 4031 4400 M15903 GO_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 939/2159 Gene Ontology BP GO:0033554 0.0612332236592365 0.141445700223799 4430 3217.36363636364 3904 0.00629889874922307 827 1.15748032132471 1.29491994481102 1 3.7319717247058 4429 3904 4477 4322 1108 827 4446 4406 2589 2859 2024 4401 M16435 GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity. 15/40 Gene Ontology BP GO:0035587 0.984494069748239 0.999999998379914 3730 3769.45454545455 3905 0.315300828482411 2241 0.960186285948682 0.960186285948682 1 2.38746050340089e-09 3729 3845 2241 4312 4121 3905 2654 3698 4326 4498 4135 4402 M12568 GO_NOSE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOSE_DEVELOPMENT.html The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). 5/29 Gene Ontology BP GO:0043584 0.285817682924741 0.404712260390233 4180 3602.81818181818 3908 0.0331014492145152 1414 0.402891078049808 -0.217154287001266 -1 0.600794103008339 4179 4079 3933 3720 3908 4336 3299 1414 2821 3526 4416 4403 M16567 GO_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. 22/56 Gene Ontology BP GO:0051972 0.878859116702268 0.937274247587117 4505 3827 3909 0.174603174603175 2699 0.297786190220958 -0.240815865252328 -1 0.0318004084107513 4504 4223 2699 3918 3147 3453 4529 3702 3480 4533 3909 4404 M10897 GO_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 26/54 Gene Ontology BP GO:0090311 0.998181280012705 0.999999998379914 4355 3646.36363636364 3911 0.436507936507937 2461 1.10159638197239 1.10159638197239 1 2.76512843175136e-09 4354 3911 2827 4289 3973 3163 3944 3613 4189 2461 3386 4405 M12463 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. 6/12 Gene Ontology BP GO:0032096 0.45073301536226 0.570077197038129 3645 3751.27272727273 3911 0.0581573574518703 2349 0.254630788680849 -0.154269059522066 -1 0.235898955153664 3645 3078 3911 3948 2349 4228 4638 3735 4242 3494 3996 4406 M11985 GO_SPERM_CAPACITATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_CAPACITATION.html A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. 8/27 Gene Ontology BP GO:0048240 0.728637457320174 0.810897342842178 4465 3740.81818181818 3912 0.122282030001006 2399 0.245624909792479 -0.329716948417002 -1 0.0848757938994398 4464 4351 3838 3912 2854 3278 4098 2399 4246 3387 4322 4407 M13355 GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 27/57 Gene Ontology BP GO:0090199 0.99625463027824 0.999999998379914 3950 3858.63636363636 3912 0.398260378307845 3146 0.257212367553023 -0.203868412464407 -1 5.10008249918233e-10 3946 3912 3146 4043 3733 3241 4476 3628 4382 3714 4224 4408 M16662 GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. 2/12 Gene Ontology BP GO:0042487 0.996972776658104 0.999999998379914 3930 3999.7 3912 0.475052282782354 3324 0.244742134657102 -0.244742134657102 -1 4.76703647515157e-10 3928 4241 4599 NA 3896 3328 3324 3793 4566 4555 3767 4409 M15791 GO_RRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. 13/28 Gene Ontology BP GO:0000154 0.966434623535874 0.999999998379914 3405 3751.36363636364 3913 0.265502810367323 2806 0.191322316173542 -0.187559103046464 -1 3.34033832934431e-10 3405 4265 3283 3913 4003 2881 4541 2806 4440 4353 3375 4410 M15933 GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING.html The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. 10/23 Gene Ontology BP GO:0000729 0.973773128707459 0.999999998379914 3410 3718.36363636364 3913 0.281792922617409 2449 0.195420843220036 -0.287884821655211 -1 3.44979884612935e-10 3407 4626 2993 4269 3630 2449 4070 3913 4258 4383 2904 4411 M12021 GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition. 38/93 Gene Ontology BP GO:1902749 0.99024675535425 0.999999998379914 4530 3662.72727272727 3914 0.343559489783328 2285 1.33403223803043 -1.33403223803043 -1 3.38590142250795e-09 4529 4284 2285 4169 4539 2899 3914 3075 4355 2648 3593 4412 M12933 GO_ONE_CARBON_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_COMPOUND_TRANSPORT.html The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/11 Gene Ontology BP GO:0019755 0.972386511855113 0.999999998379914 3925 3648.90909090909 3914 0.301587301587302 1776 0.60876632847396 -0.47333207527243 -1 1.44891332004956e-09 3921 2181 3982 1776 3509 4552 4230 3898 3914 3607 4568 4413 M14069 GO_CELLULAR_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 3/13 Gene Ontology BP GO:0071294 0.663427224845798 0.758360461288678 4190 3517.09090909091 3914 0.103174603174603 2184 0.289608657874088 0.236562088243434 1 0.132053436092354 4187 2474 4179 2637 2849 4141 4633 2184 3069 3914 4421 4414 M14075 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/23 Gene Ontology BP GO:0051590 0.765598107310867 0.844889791209468 4075 3616.18181818182 3915 0.135039825949185 1803 0.169547078932392 -0.220715101962746 -1 0.047109473565198 4074 4272 4180 4040 3346 3248 1803 3049 4438 3915 3413 4415 M10472 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. 9/16 Gene Ontology BP GO:0032211 0.993145890866877 0.999999998379914 4500 3970.72727272727 3916 0.392431706809446 3037 0.201856626990271 -0.192667021110506 -1 3.62168113686825e-10 4498 4519 3591 4402 3729 3739 4496 3227 4524 3037 3916 4416 M12476 GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. 7/12 Gene Ontology BP GO:0006677 0.663427224845798 0.758360461288678 4390 3660.63636363636 3916 0.103174603174603 1746 0.42036218629366 -0.327140375350894 -1 0.191673382743417 4387 1746 3916 2864 4356 4194 4196 3764 3080 3499 4265 4417 M12296 GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. 8/21 Gene Ontology BP GO:0048714 0.999490138554504 0.999999998379914 3905 4041.63636363636 3920 0.531461570724242 3459 0.308509268578477 -0.218602676027472 -1 6.47008329020329e-10 3903 4077 3886 3920 4612 4560 3646 3581 4396 3459 4418 4418 M13953 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. 15/41 Gene Ontology BP GO:1904358 0.891073518496821 0.9463070325665 3920 3825.63636363636 3920 0.182539682539683 2427 0.312608776380933 -0.237184836290051 -1 0.0284406138628341 3920 4414 2427 4264 3354 3991 4016 3725 3499 3889 4583 4419 M13877 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS.html The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. 36/110 Gene Ontology BP GO:0017156 0.980714389232142 0.999999998379914 3865 3935.81818181818 3921 0.301587301587302 2950 0.285306297739683 0.274731093732461 1 5.85039500947438e-10 3864 4127 2950 4447 4064 3814 4493 3538 3921 3862 4214 4420 M10434 GO_MRNA_SPLICE_SITE_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_SPLICE_SITE_SELECTION.html Selection of a splice site by components of the assembling spliceosome. 15/42 Gene Ontology BP GO:0006376 0.692177414023885 0.781181267212663 3835 3494.36363636364 3922 0.101574930238658 1802 0.245913942263583 -0.235908410772399 -1 0.100110657106804 3831 4263 3080 4284 4152 2088 3993 3996 3922 3027 1802 4421 M14097 GO_VIRION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRION_ASSEMBLY.html A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. 24/47 Gene Ontology BP GO:0019068 0.354371232721076 0.478576391368225 2940 3672.18181818182 3922 0.0389948484938515 974 0.229013324465023 0.222565833531404 1 0.278217272909794 2939 4554 2830 4513 3593 4419 974 4595 4397 3922 3658 4422 M16031 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. 29/70 Gene Ontology BP GO:0042273 0.987849051404904 0.999999998379914 4390 3958.18181818182 3924 0.330310248148619 3035 0.184214519191467 -0.200221863157494 -1 3.15050839238519e-10 4388 4289 3404 4548 3626 3713 3844 3035 4367 4402 3924 4423 M15769 GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to a muscle, across a synapse. 9/40 Gene Ontology BP GO:0007274 0.354875738216424 0.479118363634445 1925 3242.09090909091 3926 0.0428845263445574 1510 0.23451646023008 0.22647554224994 1 0.284465200557396 1925 4518 4454 4029 3926 2604 1510 1532 4236 4348 2581 4424 M13676 GO_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the cell cycle. 560/1342 Gene Ontology BP GO:0051726 0.0186071782939426 0.0630441631817949 4255 3185.36363636364 3927 0.00187648416736923 591 1.26844889009934 1.40203738672915 1 5.77949578683008 4254 4214 4113 4108 591 1323 3934 3927 2879 2680 3016 4425 M13943 GO_LIPID_PARTICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. 6/19 Gene Ontology BP GO:0034389 0.717647492011146 0.802824365478077 3930 3576.27272727273 3927 0.118790511170587 2153 0.145217651439631 -0.220693126452923 -1 0.0525752657028804 3927 3927 4161 4018 4293 3390 2633 2153 4496 3883 2458 4426 M15480 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. 4/17 Gene Ontology BP GO:0046639 0.44850862347306 0.568024695785855 2030 3082.90909090909 3929 0.0577766284057876 1188 0.252607975797844 0.252607975797844 1 0.235526954771371 2027 3929 4414 3945 4057 1726 1188 1950 4450 4290 1936 4427 M12020 GO_HISTONE_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MONOUBIQUITINATION.html The modification of histones by addition of a single ubiquitin group. 19/26 Gene Ontology BP GO:0010390 0.956393533790447 0.995524744274429 4555 3910.36363636364 3930 0.247818221459149 3165 0.166031168700604 0.172005434758933 1 0.00122764434596894 3930 4506 3165 4469 3336 4190 3621 3296 4553 3394 4554 4428 M15078 GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. 7/18 Gene Ontology BP GO:1904152 0.611528287655612 0.713757124078685 3455 3509.72727272727 3931 0.0902209329708518 1656 0.257845791232475 -0.339520686343064 -1 0.143336006759025 3454 3964 4344 4257 3404 1656 3538 3931 4187 4175 1697 4429 M12590 GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. 6/18 Gene Ontology BP GO:0002830 0.640349828096572 0.737041574967992 4330 3771.72727272727 3936 0.0972073238727379 2689 0.553867722449227 -0.526849962983443 -1 0.278583526550534 4329 2946 3936 3385 2689 4386 3585 4240 3967 3532 4494 4430 M14172 GO_ZINC_II_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_II_ION_TRANSPORT.html The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 10/27 Gene Ontology BP GO:0006829 0.653506813440324 0.749008179413336 4445 3635.90909090909 3936 0.0918573684102852 2087 0.331009082897351 0.311743305662228 1 0.157702062387234 4445 4149 2087 4122 2647 3872 2811 3994 3699 3936 4233 4431 M14173 GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 7/18 Gene Ontology BP GO:0070498 0.875013950314826 0.935816355965542 2450 3617.63636363636 3937 0.187756669040367 2130 0.171045191596029 0.197509953200737 1 0.0187047469345729 2448 4153 4197 4271 4550 3100 2130 3328 4431 3937 3249 4432 M16380 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. 10/23 Gene Ontology BP GO:0016447 0.292527908984288 0.410955243998199 4100 3568.27272727273 3940 0.0309700274472645 1385 0.847293883868049 0.847293883868049 1 1.24210905235052 4098 4022 3147 3178 3940 4063 2988 1385 3373 4485 4572 4433 M12447 GO_EATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EATING_BEHAVIOR.html The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. 11/46 Gene Ontology BP GO:0042755 0.44311907004101 0.561978104944116 2810 3573.09090909091 3941 0.0518272145461098 2211 0.333488686992734 0.267888838701197 1 0.316822146444427 2807 4341 2211 4196 2286 4182 3941 4502 3999 3489 3350 4434 M14312 GO_ARGININE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARGININE_METABOLIC_PROCESS.html The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. 9/21 Gene Ontology BP GO:0006525 0.0504873697371755 0.123611655816039 4530 2851.72727272727 3946 0.00516724828469128 302 0.577018634726521 0.577018634726521 1 1.98863232764955 4526 302 4222 806 1007 3946 2590 4098 1755 3977 4140 4435 M16541 GO_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION.html The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. 124/248 Gene Ontology BP GO:0006260 0.987447475174533 0.999999998379914 2325 3830.72727272727 3946 0.328327802829357 2322 0.839316232100865 -0.839316232100865 -1 2.06464944450264e-09 2322 4596 3391 4482 4172 2965 3946 3880 4456 4526 3402 4436 M16784 GO_DNA_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_ALKYLATION.html The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. 23/52 Gene Ontology BP GO:0006305 0.949699151114831 0.990746342716015 3825 3763.36363636364 3947 0.237988734046236 2562 0.215071921112451 -0.19429824290228 -1 0.00329614145735036 3825 3841 3361 3967 3947 2854 3989 4301 4159 4591 2562 4437 M14289 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleoside across a membrane. 7/13 Gene Ontology BP GO:1901642 0.600039668265786 0.703317874499278 4370 3689.45454545455 3950 0.0875655126115427 1947 0.296364829216254 0.235061227771769 1 0.171947012426094 4370 3221 4219 3045 3707 4433 3234 1947 3950 3969 4489 4438 M14229 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. 4/32 Gene Ontology BP GO:1902547 0.692053852342561 0.781181267212663 4210 3652.72727272727 3952 0.111111111111111 2234 0.339898317511304 0.285339264290593 1 0.138371349013268 3801 2834 4209 2349 4600 4616 2234 4206 3140 3952 4239 4439 M15325 GO_COENZYME_A_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 6/11 Gene Ontology BP GO:0015937 0.975368714677481 0.999999998379914 3955 4001.81818181818 3954 0.30952380952381 3513 0.206975792350066 -0.201983617879098 -1 3.75840012869986e-10 4298 3513 4387 3590 3954 3640 3916 3954 3928 4238 4602 4440 M13470 GO_PROTEIN_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MONOUBIQUITINATION.html Addition of a single ubiquitin group to a protein. 31/65 Gene Ontology BP GO:0006513 0.975172587239457 0.999999998379914 4360 3796.54545454545 3955 0.285364348086681 2467 0.211429909770523 -0.230888542087969 -1 3.8773574978068e-10 4359 4399 3185 4230 3955 2467 4383 3200 4484 3748 3352 4441 M11432 GO_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 28/50 Gene Ontology BP GO:0044088 0.514011397665828 0.627050688219243 4475 3699.81818181818 3957 0.0634920634920635 2508 0.734831567556784 0.734831567556784 1 0.565383472877004 4472 3422 3311 4001 4301 2508 4341 4426 2709 3250 3957 4442 M14711 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization. 7/22 Gene Ontology BP GO:0031116 0.471543377034432 0.585885825439918 3070 3329.27272727273 3957 0.0617881056045276 1833 0.226111106911195 -0.252016869901325 -1 0.199281527600816 3068 4183 4278 4011 2388 2068 3957 1833 4317 4079 2440 4443 M14367 GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING.html The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. 12/28 Gene Ontology BP GO:0051084 0.552995493099557 0.664241415362133 2540 3554.27272727273 3959 0.0705839395102159 1202 0.206390024109007 -0.219603954568369 -1 0.139193813552643 2539 4512 2923 4549 4417 1202 3959 3861 4620 3990 2525 4444 M15333 GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. 7/14 Gene Ontology BP GO:0006047 0.632427457617131 0.731410454716618 3960 3663.63636363636 3959 0.0952380952380952 2335 0.31945710187625 0.287350360445682 1 0.16471901252902 3959 2904 4390 2335 3993 3914 2825 4086 3017 4243 4634 4445 M16704 GO_METAPHASE_PLATE_CONGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAPHASE_PLATE_CONGRESSION.html The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. 29/51 Gene Ontology BP GO:0051310 0.862970125760416 0.925778718554901 4470 3599.54545454545 3960 0.165303370314716 1892 0.237209256867005 -0.242307811248634 -1 0.0301571576403245 3263 4551 1966 4466 3960 1892 4466 2811 4578 4572 3070 4446 M14263 GO_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APPETITE.html Any process which modulates appetite, the desire or physical craving for food. 10/23 Gene Ontology BP GO:0032098 0.946850919340621 0.988805402271368 3245 3760.90909090909 3962 0.234163646758117 2694 0.327324340407657 0.404907603772514 1 0.00607464096586131 3244 3437 2694 4187 3300 4285 3979 4292 4106 3962 3884 4447 M15279 GO_RESPONSE_TO_HYDROPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROPEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. 13/26 Gene Ontology BP GO:0033194 0.232850105696956 0.342669743502683 4350 3548.54545454545 3962 0.0238095238095238 1770 0.989745402399581 -0.989745402399581 -1 1.74742963989994 4348 3636 2289 2380 4350 4634 3962 3141 1770 4227 4297 4448 M11471 GO_MANGANESE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_TRANSPORT.html The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/14 Gene Ontology BP GO:0006828 0.999995232268502 0.999999998379914 3835 4037.09090909091 3963 0.706349206349206 3262 0.193317832502014 0.142065126682693 1 3.39363314626016e-10 3833 3902 3752 3963 4419 3934 4099 4554 4533 3262 4157 4449 M12983 GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. 6/20 Gene Ontology BP GO:0014821 0.429513940365597 0.548770837951972 4350 3687.90909090909 3963 0.0545806133433433 1663 0.404527773042809 -0.233246855355839 -1 0.400170383344165 4347 3076 3989 3654 4305 3963 4190 1663 4090 3619 3671 4450 M16132 GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. 3/22 Gene Ontology BP GO:0002523 0.414523975040825 0.535202348257472 3775 3482.09090909091 3964 0.0521253436188319 1636 0.291729357295844 -0.410468166339148 -1 0.300627281446355 3771 4273 4515 4025 3964 2443 2740 1636 4408 4424 2104 4451 M15629 GO_NUCLEAR_ENVELOPE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_DISASSEMBLY.html The controlled breakdown of the nuclear envelope in the context of a normal process. 28/57 Gene Ontology BP GO:0051081 0.992241128874358 0.999999998379914 4240 3842.27272727273 3965 0.357070277618703 2971 0.28163597389906 -0.249161397633954 -1 5.75237063637511e-10 4240 3424 2971 3965 3639 3194 4592 4038 4123 4319 3760 4452 M16625 GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that modulates the frequency, rate or extent of viral release from host cell. 17/50 Gene Ontology BP GO:1902186 0.921001800389416 0.968564294271361 3970 3663.09090909091 3967 0.206067863991888 2193 0.274223428056251 -0.284448200541857 -1 0.0144389834664616 3967 4040 2581 4192 3650 2193 4453 3879 4379 4550 2410 4453 M14496 GO_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 18/38 Gene Ontology BP GO:0001935 0.415320710913563 0.535202348257472 4285 3498.27272727273 3969 0.0476190476190476 1983 0.400528008715617 -0.40998148833104 -1 0.412744358465235 4282 4139 1983 4197 2543 3969 3020 3825 2374 4030 4119 4454 M15986 GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. 4/14 Gene Ontology BP GO:0003417 0.519191466287938 0.632373026751022 4385 3751.18181818182 3969 0.0706116660921082 2464 0.229524721275924 -0.258267040588035 -1 0.173399547648599 4383 3969 4492 3492 2464 3179 3505 3126 4281 4396 3976 4455 M14031 GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. 7/10 Gene Ontology BP GO:0043562 0.544439701582726 0.656068916285646 4560 3807.09090909091 3970 0.0756113873085177 2518 0.240753622614682 0.153717667459408 1 0.167282716018099 4558 3825 4175 3641 2518 4584 3999 2731 3972 3905 3970 4456 M14089 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 17/43 Gene Ontology BP GO:0051024 0.646794695709086 0.742881308914616 3920 3863.54545454545 3972 0.0902719929540848 2385 0.297511568335338 -0.265651569315514 -1 0.145771276641327 4382 3917 2385 4215 2634 3773 4631 4457 4214 3919 3972 4457 M12888 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 7/21 Gene Ontology BP GO:0060211 0.916887921026626 0.965260512756181 4340 3902.54545454545 3975 0.220230193947805 3257 0.224845042880876 -0.217841831631718 -1 0.0131054930909426 4339 4237 3975 4068 3257 3682 3759 4590 3979 3594 3448 4458 M13278 GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. 11/23 Gene Ontology BP GO:0070233 0.926929315216114 0.972722749462082 4210 3727.18181818182 3975 0.211677494539973 1975 0.352105652256536 0.290631157533566 1 0.0160530201150968 3642 4207 1975 3975 3416 4173 3293 4109 4210 3694 4305 4459 M14848 GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING.html Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 7/17 Gene Ontology BP GO:0090036 0.33296556889208 0.452829272514917 3935 3511.72727272727 3976 0.0396825396825397 1422 1.46584243959724 1.46584243959724 1 1.91441310299245 3931 4112 4304 3976 4621 4104 2025 3727 2149 1422 4258 4460 M15019 GO_NUCLEAR_ENVELOPE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. 50/100 Gene Ontology BP GO:0006998 0.988438980056112 0.999999998379914 3235 3867.27272727273 3977 0.333333333333333 3231 0.276936698243337 -0.269138685706333 -1 5.62686575719395e-10 3917 3316 3232 4076 4553 3231 3875 3977 3985 4156 4222 4461 M11000 GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION.html The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. 14/26 Gene Ontology BP GO:0006271 0.995560623481128 0.999999998379914 4005 3839.63636363636 3980 0.388888888888889 3135 0.187801979670858 -0.237312556957064 -1 3.2463197103454e-10 4001 4044 3235 3980 4585 3579 3638 4059 4109 3135 3871 4462 M15540 GO_CELL_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between cells. 57/122 Gene Ontology BP GO:0007043 0.688931733618296 0.778843447574811 4350 3528.63636363636 3981 0.100717849142508 1445 0.931951048591966 -0.931951048591966 -1 0.383998455641897 4349 3678 1644 4129 4635 1445 3863 4056 3981 4300 2735 4463 M11116 GO_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_PROLIFERATION.html The expansion of a T cell population by cell division. Follows T cell activation. 21/59 Gene Ontology BP GO:0042098 0.232850105696956 0.342669743502683 4480 3614.81818181818 3982 0.0238095238095238 1893 1.38916827744188 -1.38916827744188 -1 2.4526245001958 4478 3982 2868 2887 4567 4600 4467 4188 1893 2318 3515 4464 M15708 GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. 9/27 Gene Ontology BP GO:0039531 0.0140502934442529 0.0521884099693332 4620 3494.36363636364 3985 0.00141399269200393 503 0.371638710504839 -0.273295977206154 -1 1.80909122782829 4617 2606 4444 2733 503 3397 4147 3985 3567 4334 4105 4465 M15121 GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 22/55 Gene Ontology BP GO:0002756 0.850621352955467 0.915455969875182 4380 3795.45454545455 3986 0.158730158730159 2483 0.242726033198262 -0.24553545971469 -1 0.035345239485742 4376 3952 3259 4037 4326 3986 3694 2483 3418 4187 4032 4466 M16419 GO_RRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. 9/20 Gene Ontology BP GO:0031167 0.970991449082755 0.999999998379914 3750 3882.90909090909 3986 0.298136587744676 2736 0.16173287217127 -0.162657631591132 -1 2.55008471014676e-10 3748 4268 4562 3986 3851 2736 4357 2939 4504 4495 3266 4467 M16330 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 12/38 Gene Ontology BP GO:0035774 0.0563776551475056 0.133893326265917 3600 3399.45454545455 3990 0.005261496067084 991 0.26178284564603 -0.251979325499131 -1 0.867725915005554 3599 3990 2615 3849 1014 4120 991 4322 4295 4475 4124 4468 M10692 GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER.html The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 6/16 Gene Ontology BP GO:0090557 0.995779548661555 0.999999998379914 3745 3850.54545454545 3992 0.42119018127895 3075 0.273428817949699 -0.276191571624788 -1 5.53317980968018e-10 3745 4211 3619 4191 3784 3992 3206 4106 4252 3075 4175 4469 M13655 GO_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_SALVAGE.html Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. 8/17 Gene Ontology BP GO:0043174 0.893676988086843 0.948637918538457 3195 3788.54545454545 3993 0.200786654826695 2386 0.183216109995703 -0.173593258094442 -1 0.0159256534748068 3193 4632 4111 4583 4408 2418 3525 3993 4627 3798 2386 4470 M14235 GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 9/20 Gene Ontology BP GO:0010745 0.946596086373448 0.988761671323266 4310 3876.45454545455 3994 0.253968253968254 2795 0.409078552703972 -0.394936252046762 -1 0.00762169998484674 4310 2795 4211 3179 4217 3994 4344 4298 3788 3954 3551 4471 M15702 GO_NEGATIVE_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APPETITE.html Any process that reduces appetite. 6/12 Gene Ontology BP GO:0032099 0.45073301536226 0.570077197038129 3650 3875.81818181818 3997 0.0581573574518703 2350 0.254630788680849 -0.154269059522066 -1 0.235898955153664 3646 3079 4442 3949 2350 4229 4639 3728 4243 4332 3997 4472 M16819 GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 27/55 Gene Ontology BP GO:0010823 0.687179964144382 0.777855898013402 4000 3511.90909090909 3997 0.100258634848067 1437 0.243863315192652 -0.251338684514505 -1 0.10099080680867 3997 4290 3321 4229 2740 1437 3765 4182 4197 4600 1873 4473 M15215 GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. 6/11 Gene Ontology BP GO:0070525 0.796819873908615 0.871663543578164 2900 3609.18181818182 3998 0.147315982892096 2297 0.214963104785382 -0.371047329959571 -1 0.0486731821155077 2899 4311 4370 3998 4461 2297 4570 2305 3587 4214 2689 4474 M16444 GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that activates or increases the frequency, rate or extent of gluconeogenesis. 4/18 Gene Ontology BP GO:0045722 0.456482706899761 0.575827184565673 4505 3889.45454545455 3999 0.0591479475316518 2359 0.134862561325978 -0.100156932870671 -1 0.122710256950351 3821 3827 4567 4250 2359 4503 3458 3220 4278 4502 3999 4475 M16324 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. 22/51 Gene Ontology BP GO:0019883 0.952816306723379 0.993024940991392 4000 3739.09090909091 4000 0.242407563516782 2723 0.252457793164622 -0.224638368039185 -1 0.00291304516959272 4000 4259 2723 4222 3319 3234 4337 2726 4467 4473 3370 4476 M14223 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. 6/28 Gene Ontology BP GO:0032695 0.779544422937444 0.857480396990891 4190 3884.63636363636 4001 0.140329331685022 2277 0.27557892302021 -0.210012145544429 -1 0.0698509514406215 4186 4001 4208 3701 3383 3964 4094 2277 4340 3950 4627 4477 M16416 GO_LEUKOTRIENE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_METABOLIC_PROCESS.html The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 19/54 Gene Ontology BP GO:0006691 0.925516054706081 0.971990735580262 4135 3844 4002 0.210303445881874 1968 0.874649861425705 -0.874649861425705 -1 0.0409620618111766 4134 3984 1968 4052 4002 3933 4606 3147 3830 4494 4134 4478 M10055 GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION.html The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. 7/24 Gene Ontology BP GO:0021801 0.956930203251513 0.995524744274429 4005 3947.45454545455 4003 0.26984126984127 2945 0.290529036083597 0.235976735462092 1 0.00214818912200249 4003 4047 3527 3906 4320 4409 3554 4413 3833 2945 4465 4479 M16296 GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. 9/35 Gene Ontology BP GO:0032925 0.275742742869669 0.392721949430635 4300 3737.90909090909 4003 0.0317460317460317 2135 0.348308631960268 0.369705030905917 1 0.536668841957133 4300 2469 4543 4003 4133 3114 3745 3812 2135 4464 4399 4480 M12797 GO_TELENCEPHALON_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_GLIAL_CELL_MIGRATION.html The orderly movement of glial cells through the telencephalon. 7/24 Gene Ontology BP GO:0022030 0.956930203251513 0.995524744274429 4005 4045.54545454545 4004 0.26984126984127 3555 0.290529036083597 0.235976735462092 1 0.00214818912200249 4004 4048 3962 3907 4321 4410 3555 4416 3834 3578 4466 4481 M14006 GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. 6/15 Gene Ontology BP GO:0033004 0.686161361653538 0.777035902965214 3975 4006.63636363636 4006 0.109424709784538 2781 0.353703854091075 -0.367008943168216 -1 0.147093926765035 3973 3900 4169 4006 2781 4235 4305 3972 4490 3900 4342 4482 M12639 GO_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that modulates the frequency, rate or extent of receptor internalization. 17/56 Gene Ontology BP GO:0002090 0.857653731714958 0.920926520895594 4095 3613.63636363636 4007 0.162410041011403 1860 0.185487852832329 -0.2158766801001 -1 0.0251885163407708 4091 4558 3018 4362 4007 1860 2428 4305 4624 3544 2953 4483 M13704 GO_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_LOCALIZATION.html Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. 13/39 Gene Ontology BP GO:0051647 0.990862919029022 0.999999998379914 4545 3924.81818181818 4008 0.347442386184451 2741 0.243657423737477 -0.23305012150384 -1 4.73806679495239e-10 4542 3506 2741 4008 3688 4566 4507 3085 4577 3811 4142 4484 M13695 GO_HISTONE_H4_K8_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K8_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. 11/16 Gene Ontology BP GO:0043982 0.161385165508919 0.258740097879113 4595 3802.90909090909 4017 0.0158730158730159 1632 0.814201200647222 0.814201200647222 1 1.81458732510452 4594 4468 3325 4059 3868 4017 3276 4574 1632 3807 4212 4485 M14450 GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. 10/23 Gene Ontology BP GO:0042402 0.965461615042233 0.999999998379914 3695 3835 4020 0.263592223582101 2093 0.801128877993451 0.801128877993451 1 1.9626614017782e-09 3692 3642 2093 3584 4175 4462 3835 4260 4204 4020 4218 4486 M16081 GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. 26/60 Gene Ontology BP GO:1904356 0.989865950533548 0.999999998379914 3720 4003.72727272727 4021 0.341269841269841 2576 0.245344552966138 -0.184389886672211 -1 4.78312543069091e-10 3716 4615 2576 4563 3986 4044 3572 4004 4021 4416 4528 4487 M10043 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY.html A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. 18/46 Gene Ontology BP GO:0045005 0.997344981054227 0.999999998379914 4025 3929.18181818182 4023 0.416790849375186 2940 0.208154464778013 -0.213559871703427 -1 3.78987926537991e-10 4023 4505 3110 4584 3884 2972 4421 4537 4468 2940 3777 4488 M15177 GO_INTRACELLULAR_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIPID_TRANSPORT.html The directed movement of lipids within cells. 16/57 Gene Ontology BP GO:0032365 0.773598623703844 0.851747310850593 3965 3512.09090909091 4023 0.126319501176682 1710 0.405578344630857 -0.402448370343691 -1 0.107287134977977 3965 2530 1710 2325 4361 2661 4023 4293 4132 4201 4432 4489 M14979 GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS.html The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. 5/26 Gene Ontology BP GO:0006607 0.945770587218643 0.988121700372673 2715 3657 4024 0.252823007862401 2713 0.325306222803675 0.294116318392143 1 0.00640811615234462 2713 4157 4328 4024 3349 4225 2950 3174 4442 4145 2720 4490 M14470 GO_LYMPH_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. 5/17 Gene Ontology BP GO:0036303 0.977963744897698 0.999999998379914 3915 3760.81818181818 4025 0.317168135862248 2664 0.239202897662883 -0.22978037980639 -1 4.61909851180428e-10 3915 2692 4241 3056 4160 3470 2664 4581 4161 4025 4404 4491 M14480 GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 9/17 Gene Ontology BP GO:0006152 0.89845090407627 0.951944210577773 3030 3617.27272727273 4026 0.204449769090181 2097 0.18843479297988 -0.206848174796055 -1 0.0152984950582144 3028 4181 4243 4278 4197 2097 3882 2877 4580 4026 2401 4492 M10699 GO_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CONDENSATION.html The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. 16/40 Gene Ontology BP GO:0030261 0.990331738918529 0.999999998379914 4570 3959.72727272727 4027 0.344081542970435 2255 0.183247490260538 -0.192535802830998 -1 3.12468167822064e-10 4568 4467 2255 4561 3911 3983 4027 3907 4617 3078 4183 4493 M15773 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. 10/22 Gene Ontology BP GO:0055026 0.989549637614824 0.999999998379914 4570 3770 4028 0.339426675503439 2246 0.32400629744703 -0.388740693059168 -1 6.88396680721842e-10 4569 2900 2246 3495 3881 2948 4353 4244 4457 4349 4028 4494 M15536 GO_MYELIN_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_MAINTENANCE.html The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. 7/14 Gene Ontology BP GO:0043217 0.663427224845798 0.758360461288678 4085 3537.45454545455 4029 0.103174603174603 1256 0.931951048591966 -0.931951048591966 -1 0.424943574731115 4083 1345 4419 1256 3720 4484 4029 3928 3073 4299 4276 4495 M11611 GO_REGULATION_OF_INTERLEUKIN_10_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-10 secretion. 7/20 Gene Ontology BP GO:2001179 0.935754279644986 0.980525190790266 4460 3955.90909090909 4030 0.240051048220283 3291 0.306289946790065 -0.245795686197638 -1 0.00993027125286315 4459 4375 3776 4244 3315 3841 4422 4030 4463 3299 3291 4496 M11451 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. 6/12 Gene Ontology BP GO:0070202 0.999668783445025 0.999999998379914 3340 3979.90909090909 4033 0.551243033554395 3254 0.208407077558015 -0.128578742741406 -1 3.79662586608105e-10 3338 4422 3748 4377 4025 4198 4166 3811 4407 3254 4033 4497 M11887 GO_PHAGOLYSOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOLYSOSOME_ASSEMBLY.html The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. 13/19 Gene Ontology BP GO:0001845 0.902157871246138 0.954802597719585 4330 3914.45454545455 4036 0.19047619047619 2569 0.23198002461126 -0.183756754944583 -1 0.0176872412143923 4328 4515 2569 4036 4523 3601 3775 4529 3542 3364 4277 4498 M14291 GO_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_CHEMOTAXIS.html The movement of a macrophage in response to an external stimulus. 8/17 Gene Ontology BP GO:0048246 0.992260012623439 0.999999998379914 4040 3934.81818181818 4039 0.385001544297557 3204 0.399950784660214 -0.566753783078016 -1 8.91223762818119e-10 4039 4374 4220 4207 4071 3389 3695 3204 4301 3971 3812 4499 M16437 GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. 5/15 Gene Ontology BP GO:1900121 0.98081526679679 0.999999998379914 4040 3899.18181818182 4040 0.326565166767545 2629 0.167240370691724 -0.179511101364199 -1 2.69717502513137e-10 4040 4115 4564 4203 3819 2629 3163 3857 4337 4499 3665 4500 M12787 GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. 9/20 Gene Ontology BP GO:0000466 0.709190361093696 0.795297901954175 4240 3951.81818181818 4043 0.116185993854987 2815 0.222023262607794 -0.188881957489844 -1 0.0838298214408886 4236 3896 3960 4063 2815 3826 4253 4376 4426 3576 4043 4501 M16258 GO_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progress through the mitotic cell cycle. 310/683 Gene Ontology BP GO:0007346 0.623416619931196 0.724536512225417 4320 3579.63636363636 4043 0.0849561159205116 1316 1.34834564013035 1.46713195702565 1 0.716225004328787 4317 4432 2910 4415 4043 1316 4636 4634 3059 2676 2938 4502 M15020 GO_ASYMMETRIC_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. 18/51 Gene Ontology BP GO:0008105 0.799420090207205 0.873754114602649 4590 3673.36363636364 4050 0.135884919090201 2250 0.230761531828443 -0.267178390008685 -1 0.0513390751596681 4590 4225 3159 3850 4050 2270 4068 2250 4364 4157 3424 4503 M14652 GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. 5/12 Gene Ontology BP GO:0051292 0.724510625044687 0.808436152867696 2360 3291.72727272727 4052 0.12095626027336 1605 0.235210965976987 -0.235210965976987 -1 0.0824559103681504 2360 4052 4266 4246 4422 1605 1944 2624 4352 4065 2273 4504 M10625 GO_POSITIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RNA_SPLICING.html Any process that activates or increases the frequency, rate or extent of RNA splicing. 14/44 Gene Ontology BP GO:0033120 0.996212435208048 0.999999998379914 4430 3848.81818181818 4055 0.397647224887485 2874 0.224204818512595 -0.214641375704258 -1 4.21854058551759e-10 4430 4622 2874 4553 3749 2890 4055 4126 4523 3062 3453 4505 M14619 GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. 17/32 Gene Ontology BP GO:0000289 0.980714389232142 0.999999998379914 4180 3900.09090909091 4057 0.301587301587302 2903 0.184917457739383 -0.209400293107478 -1 3.16928197027066e-10 4180 4331 3395 3915 4141 2903 4602 4514 3924 4057 2939 4506 M14943 GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. 8/29 Gene Ontology BP GO:1900271 0.56356619637467 0.671521038842447 3885 3855.18181818182 4059 0.0795677264942968 1886 0.403342947378695 -0.367181837985366 -1 0.264775683539734 3881 3302 4322 3901 3880 4280 4059 1886 4193 4133 4570 4507 M13377 GO_GRANULOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_ACTIVATION.html The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 11/32 Gene Ontology BP GO:0036230 0.633257802728945 0.731410454716618 4060 3725.36363636364 4060 0.0871562553139906 2621 0.229488867637935 0.186220912175242 1 0.118329438994436 4060 4229 3012 4200 2621 2990 4130 4359 4279 3723 3376 4508 M14977 GO_HISTONE_H4_K5_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K5_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. 11/16 Gene Ontology BP GO:0043981 0.161385165508919 0.258740097879113 4595 3834.45454545455 4060 0.0158730158730159 1633 0.814201200647222 0.814201200647222 1 1.81458732510452 4595 4469 3326 4060 3869 4018 3277 4576 1633 4143 4213 4509 M14633 GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 8/21 Gene Ontology BP GO:0010649 0.0682068492278886 0.152545472526535 3635 3735.54545454545 4061 0.0070395484949848 426 0.268016702692153 -0.158529756948649 -1 0.830766215294929 3632 4151 4263 4038 3849 3630 426 4384 4509 4061 4148 4510 M11479 GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. 8/22 Gene Ontology BP GO:0051131 0.990126281873577 0.999999998379914 4440 3879.09090909091 4063 0.369844004700251 2791 0.164704023999658 -0.123093742439893 -1 2.62943609929042e-10 4438 4076 3755 4098 4000 2791 4164 4063 4399 3265 3621 4511 M16889 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 7/25 Gene Ontology BP GO:1900151 0.916887921026626 0.965260512756181 4340 4055.90909090909 4069 0.220230193947805 3258 0.224845042880876 -0.217841831631718 -1 0.0131054930909426 4340 4238 4632 4069 3258 3683 3760 4585 3980 4621 3449 4512 M12669 GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. 10/21 Gene Ontology BP GO:0046500 0.415320710913563 0.535202348257472 4145 3706.81818181818 4070 0.0476190476190476 2425 0.282220942341276 -0.280115322114652 -1 0.290828854003761 4145 4103 2986 4367 4091 3202 4081 4070 2425 3549 3756 4513 M13542 GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. 39/94 Gene Ontology BP GO:0050891 0.0872972017957615 0.1631726682519 4275 3616.54545454545 4074 0.00826970480800651 879 0.998542506531935 -0.998542506531935 -1 2.9843038930213 4271 4364 879 4430 4500 4074 3807 2643 4257 2659 3898 4514 M15747 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 5/18 Gene Ontology BP GO:2000515 0.856440260541471 0.920049081372987 2635 3550.81818181818 4075 0.17642478910408 2073 0.266046465875887 0.252607975797844 1 0.036546126505055 2631 4114 4451 4075 4605 2562 2073 2935 4532 4343 2738 4515 M16866 GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. 8/14 Gene Ontology BP GO:0046498 0.51629272907301 0.62933765846311 2740 3358.36363636364 4075 0.070052863326749 1196 0.219280092417642 -0.220086432182006 -1 0.167399310049011 2736 4075 4627 4239 4640 1196 1465 3123 4125 4613 2103 4516 M16085 GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. 8/36 Gene Ontology BP GO:0048486 0.992735565696391 0.999999998379914 4080 4013.36363636364 4077 0.388888888888889 3292 0.380441601196268 -0.443454723585478 -1 8.3912003677721e-10 4077 3405 4505 3292 4592 3700 4492 3591 4110 4419 3964 4517 M16084 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. 17/42 Gene Ontology BP GO:0032733 0.557443745451391 0.666249592815201 3695 3643 4080 0.0714285714285714 2205 0.356061440800003 -0.203042826136395 -1 0.238363503545861 3691 4261 2261 4080 4169 4474 3235 2205 2803 4418 4476 4518 M16908 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 3/32 Gene Ontology BP GO:0032225 0.913690271105068 0.963056510497351 4460 4022 4080 0.217280821431628 3131 0.192495159634739 -0.201711191418645 -1 0.0119453185771785 4457 4080 4635 3911 3242 3546 3910 3131 4439 4628 4263 4519 M15686 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. 26/69 Gene Ontology BP GO:0002711 0.557480006049334 0.666249592815201 4340 3892.72727272727 4084 0.0714354882296338 2476 0.301275538694998 -0.250764302174611 -1 0.201687362621918 4551 4063 2637 4084 2476 4338 4256 4337 3806 4329 3943 4520 M13425 GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM.html Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. 8/41 Gene Ontology BP GO:0030277 0.99061216470023 0.999999998379914 4330 4009.81818181818 4086 0.373015873015873 2919 0.335072861302306 -0.198491101541927 -1 7.17952464663037e-10 4326 4570 4074 4158 4054 2919 4116 4196 4086 3737 3872 4521 M11012 GO_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PHASE_TRANSITION.html The cell cycle process by which a cell commits to entering the next cell cycle phase. 152/387 Gene Ontology BP GO:0044770 0.936989803160346 0.981376868051768 2545 3665.81818181818 4087 0.222222222222222 2544 1.05239090193808 1.31671332347541 1 0.0326134724539942 2544 4158 3002 4231 4087 4562 2657 4339 3680 2818 4246 4522 M15463 GO_RECIPROCAL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_DNA_RECOMBINATION.html A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules. 23/42 Gene Ontology BP GO:0035825 0.731555171783735 0.81336462226817 2035 3457.63636363636 4087 0.112685188508346 1546 0.229838312191902 -0.219114711681325 -1 0.0782696454699648 2032 4365 2788 4341 4224 1546 3410 4087 4590 4281 2370 4523 M16397 GO_RECIPROCAL_MEIOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_MEIOTIC_RECOMBINATION.html The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. 23/42 Gene Ontology BP GO:0007131 0.731555171783735 0.81336462226817 2035 3477.45454545455 4088 0.112685188508346 1547 0.229838312191902 -0.219114711681325 -1 0.0782696454699648 2033 4366 2789 4342 4225 1547 3411 4088 4591 4489 2371 4524 M14847 GO_DETERMINATION_OF_ADULT_LIFESPAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETERMINATION_OF_ADULT_LIFESPAN.html The control of viability and duration in the adult phase of the life-cycle. 9/19 Gene Ontology BP GO:0008340 0.991681601153454 0.999999998379914 3395 3929.09090909091 4090 0.38055325673705 3105 0.294497913174952 -0.272671797543424 -1 6.0958780730776e-10 3391 4105 4303 4090 4063 3350 3519 4614 4568 4112 3105 4525 M14886 GO_MACROMOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. 509/1194 Gene Ontology BP GO:0009057 0.037588353765255 0.100127783437796 4090 3310.63636363636 4090 0.0038239712446865 210 1.46277588014838 1.62178236941306 1 5.54937526659616 4090 4483 4310 4351 3335 210 4387 4637 2567 2702 1345 4526 M16839 GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-12 production. 41/124 Gene Ontology BP GO:0032655 0.617264536435822 0.719186761021712 4145 3688.72727272727 4093 0.0836071322022904 2048 0.975157604060794 0.975157604060794 1 0.529905738994689 4144 4320 2048 4395 2598 4220 3956 4093 3920 2679 4203 4527 M16619 GO_NUCLEOTIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SALVAGE.html Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. 8/14 Gene Ontology BP GO:0043173 0.142343119922718 0.243514777377001 4550 3183.36363636364 4094 0.0152378279063262 612 0.252433310206385 -0.252698629763794 -1 0.587828360549881 2301 4113 4593 4094 4617 1203 612 3152 4548 4546 1238 4528 M10092 GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. 8/22 Gene Ontology BP GO:0050855 0.356618125901394 0.479556776820555 4100 3660.45454545455 4097 0.043143344163683 1015 0.291414519215733 0.201431095280005 1 0.353042369163997 4097 4110 3530 3957 4606 4605 1015 2630 4230 2954 4531 4529 M14853 GO_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. 11/21 Gene Ontology BP GO:0030225 0.99444801183352 0.999999998379914 4100 3986.63636363636 4097 0.376337162183595 2956 0.242787905857046 -0.25058334369598 -1 4.71484433589184e-10 4605 4072 2956 4097 3677 3953 4171 4325 4097 4114 3786 4530 M13567 GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. 6/12 Gene Ontology BP GO:0008655 0.99164548728797 0.999999998379914 4640 4035 4098 0.380284851335832 3008 0.177053397496469 -0.162348862334857 -1 2.95925429729131e-10 3797 4638 4098 4581 3778 3008 4539 4429 4640 3775 3102 4531 M13298 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING.html Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. 14/30 Gene Ontology BP GO:0006297 0.999996087408428 0.999999998379914 4055 4102.09090909091 4100 0.677591958820501 3323 0.161637026688345 -0.175420489719537 -1 2.54752493782528e-10 4053 4202 3323 4100 4563 3863 4598 4213 4558 3701 3949 4532 M15350 GO_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_CAPPING.html Any process that modulates the frequency, rate or extent of telomere capping. 10/26 Gene Ontology BP GO:1904353 0.698152987361708 0.785443256680497 3880 3914.63636363636 4100 0.103174603174603 2516 0.278900132487086 -0.1190649578868 -1 0.111037608007692 3878 4517 2516 4030 4511 4567 3457 4147 3089 4249 4100 4533 M12141 GO_REGULATION_OF_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of bone development. 9/31 Gene Ontology BP GO:1903010 0.999076587775772 0.999999998379914 4500 4040.54545454545 4101 0.502790335145653 3004 0.238450285831325 0.300594071510605 1 4.5989982955348e-10 3004 4471 3856 4500 4101 4587 4323 3847 4499 3421 3837 4534 M16127 GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 9/20 Gene Ontology BP GO:0009226 0.282900111526732 0.401070295517134 4365 3584.18181818182 4101 0.0327071769216872 2008 0.285137942671539 0.258145795291054 1 0.429448876250714 4363 3363 4514 2443 2008 4443 2800 4101 2632 4423 4336 4535 M16623 GO_COPULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPULATION.html The act of sexual union between male and female, involving the transfer of sperm. 7/20 Gene Ontology BP GO:0007620 0.877063259242643 0.937000624174779 3115 3962 4103 0.189098377255966 3112 0.30534976163603 0.267672847721532 1 0.0327550911851177 3112 4376 4594 4433 3161 4103 3489 3691 4265 4549 3809 4536 M13619 GO_OXYGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORT.html The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 5/19 Gene Ontology BP GO:0015671 0.33296556889208 0.452829272514917 4220 3758.81818181818 4106 0.0396825396825397 2175 0.649696430990385 -0.54614124970488 -1 0.848513678354655 4219 2404 4106 2860 3914 4130 4589 4627 2175 3790 4533 4537 M15633 GO_FOREBRAIN_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. 2/14 Gene Ontology BP GO:0021877 0.99935532211245 0.999999998379914 3665 4113.2 4107 0.557938665441388 3643 0.202647396753008 0.202647396753008 1 3.64280044775854e-10 3661 4055 4434 NA 4304 3967 4077 3643 4534 4320 4137 4538 M13634 GO_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_SORTING_PATHWAY.html A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. 6/12 Gene Ontology BP GO:0071985 0.493013851254528 0.610254148593648 4360 4001.45454545455 4109 0.0656714720183041 2429 0.189490185311585 -0.149321607993855 -1 0.154276401705223 4360 4522 4109 4274 2429 3482 4031 3966 4470 3794 4579 4539 M13382 GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. 8/19 Gene Ontology BP GO:0007095 0.875238343576939 0.935816355965542 3095 3970.81818181818 4111 0.187902612807101 2133 0.154315592818482 -0.09778687320525 -1 0.0168752718614 3092 4635 4064 4451 4597 4111 2133 4458 4584 3725 3829 4540 M14852 GO_MISMATCH_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR.html A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. 18/34 Gene Ontology BP GO:0006298 0.992386060898762 0.999999998379914 3070 3811.27272727273 4113 0.358171443112287 2746 0.205756218008076 -0.235012018346595 -1 3.72582861307545e-10 3069 4507 3104 4558 4590 2746 4399 3210 4567 4113 3061 4541 M10596 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. 17/29 Gene Ontology BP GO:1902108 0.996155202077478 0.999999998379914 3890 3934.45454545455 4114 0.396825396825397 3056 0.268630767548438 -0.22249491742952 -1 5.4050369255355e-10 3888 4330 3102 4495 4193 3748 3377 4455 4114 3056 4521 4542 M14855 GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 18/30 Gene Ontology BP GO:0032878 0.87159867672908 0.933310114403395 3675 3733.27272727273 4116 0.170224011048206 2227 0.324918599591848 -0.298864509772096 -1 0.036968080839202 3674 4140 2227 4541 3573 4588 2965 2429 4415 4116 4398 4543 M16064 GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. 10/29 Gene Ontology BP GO:0045346 0.418385342288812 0.537808179470363 4520 3757.45454545455 4116 0.048073947154234 1589 0.242322174009926 -0.195809704849342 -1 0.247772898073603 4518 3995 2550 3564 4128 3706 4270 1589 4485 4411 4116 4544 M16532 GO_CELLULAR_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_DEFENSE_RESPONSE.html A defense response that is mediated by cells. 29/121 Gene Ontology BP GO:0006968 0.219707096151514 0.33034327960864 4260 3690.27272727273 4116 0.0223008410756225 1776 0.653874098340854 0.653874098340854 1 1.19392655573972 4259 3880 1812 4116 1776 4328 3575 4604 3517 4524 4202 4545 M13690 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER.html The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. 12/39 Gene Ontology BP GO:0048791 0.898636975008051 0.951944210577773 4120 3898.27272727273 4127 0.187870259522333 1955 0.328555629716502 -0.319924677663298 -1 0.0266745149495589 4119 4148 1955 4127 3156 4067 4482 4371 4133 3805 4518 4546 M10874 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. 36/130 Gene Ontology BP GO:0002704 0.361160165807181 0.481305008565655 3350 3641.45454545455 4129 0.0399179223400968 2122 0.305655176579764 0.324552599147283 1 0.368461070501902 3346 4129 2480 4273 2122 4569 3281 4181 4172 3108 4395 4547 M14417 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. 30/115 Gene Ontology BP GO:0002707 0.523760148029073 0.635662411961002 4230 3859.90909090909 4131 0.0652156553447153 2422 0.304326684740887 -0.28101419965934 -1 0.227307521577643 4228 4167 2525 4378 2422 3848 4131 4441 4129 4008 4182 4548 M10851 GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a sphingolipid. 5/14 Gene Ontology BP GO:0090520 0.999886035595653 0.999999998379914 3345 4030.27272727273 4133 0.596654772606996 3103 0.226781880906516 0.250086028416825 1 4.28736691708155e-10 3342 4353 3648 4133 4588 4168 4557 3826 4550 3103 4065 4549 M13041 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. 12/21 Gene Ontology BP GO:1904357 0.999586098348695 0.999999998379914 4270 3970.90909090909 4133 0.507455814836806 2658 0.190105579158674 -0.186482410119435 -1 3.30784259101487e-10 4267 4569 2658 4555 4051 4360 3348 3562 4544 3633 4133 4550 M13816 GO_NEGATIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BEHAVIOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 5/21 Gene Ontology BP GO:0048521 0.995337309943354 0.999999998379914 4410 3968.72727272727 4136 0.415393479859833 3033 0.29277226017498 0.232800650483798 1 6.04979057212279e-10 4410 4053 4136 4376 4355 3612 3033 3313 4356 3839 4173 4551 M15348 GO_REGULATION_OF_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPIRATION.html Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. 19/34 Gene Ontology BP GO:0043457 0.955240661249004 0.99491916387174 4180 3806.18181818182 4136 0.246031746031746 2557 0.344745112309721 0.304207028080422 1 0.00289487925233637 4176 4136 2557 4163 3800 4144 2686 3915 3747 4248 4296 4552 M13467 GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 8/35 Gene Ontology BP GO:0043949 0.999493225603366 0.999999998379914 4040 4151 4138 0.531746031746032 3562 0.290074005278495 -0.182991376094664 -1 5.9777275182411e-10 4038 4150 4081 4138 4125 3562 4469 4395 4347 3747 4609 4553 M13827 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. 4/17 Gene Ontology BP GO:0001956 0.955276681572306 0.99491916387174 4605 4120.54545454545 4139 0.267085351222275 3381 0.111547781781198 -0.130300519175536 -1 0.000936684252600525 4111 4427 4139 4160 3381 4281 3712 4064 4605 3843 4603 4554 M16204 GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. 34/68 Gene Ontology BP GO:0008156 0.936483940560572 0.98106835199069 4105 3850.90909090909 4144 0.221656628046405 2610 1.00744291305309 1.00744291305309 1 0.0317427218560478 4101 4545 2611 4463 3264 3424 4144 4605 4314 2610 4279 4555 M12738 GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. 2/14 Gene Ontology BP GO:0007210 0.999201699108455 0.999999998379914 4410 4087.1 4144.5 0.547314805746302 3461 0.133357412272391 -0.266310876825266 -1 1.79225330649613e-10 4409 4002 3953 NA 4383 4201 3461 4340 4471 3563 4088 4556 M14983 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. 5/18 Gene Ontology BP GO:1902285 0.994416491485565 0.999999998379914 3615 3972.18181818182 4145 0.404761904761905 3282 0.408446299637114 0.397258199919961 1 9.13912974068342e-10 3613 3452 4329 3433 4507 4004 3282 4596 4145 4147 4186 4557 M16861 GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION.html A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. 13/22 Gene Ontology BP GO:0042772 0.976521233738712 0.999999998379914 4590 3865.27272727273 4146 0.288983678398712 2204 0.343423887933794 -0.290639045755768 -1 7.40255786817527e-10 4588 4043 2204 4313 4391 2485 4159 4146 3893 4611 3685 4558 M16175 GO_IMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. 4/11 Gene Ontology BP GO:0006188 0.97589053185828 0.999999998379914 2645 3751 4147 0.311000728066089 2644 0.203915109861644 -0.203915109861644 -1 3.67665761898917e-10 2644 4574 4524 4333 4147 2956 2949 3219 4589 4434 2892 4559 M13791 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. 22/66 Gene Ontology BP GO:0002639 0.523808827948049 0.635662411961002 4230 3821 4153 0.065224342209001 2423 0.290497296557595 -0.27438128551111 -1 0.216978082481618 4227 4293 2490 4545 2423 3449 4490 4345 4153 3834 3782 4560 M16287 GO_MESODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the mesoderm. 4/23 Gene Ontology BP GO:0001710 0.76527490244494 0.844786346184464 4160 4077.90909090909 4156 0.134920634920635 3252 0.217925528114997 -0.26985539458192 -1 0.0605956471971896 4156 3873 4541 3599 3252 4118 4622 4357 3277 4461 4601 4561 M14870 GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 17/24 Gene Ontology BP GO:0090312 0.976855293803008 0.999999998379914 4620 3805 4162 0.289909359499214 2153 1.10159638197239 1.10159638197239 1 2.76512843175136e-09 4616 4300 2417 4275 3438 3910 4162 4420 4191 2153 3973 4562 M13105 GO_MATURATION_OF_LSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_LSU_RRNA.html Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. 7/17 Gene Ontology BP GO:0000470 0.996954630403975 0.999999998379914 4400 4106.72727272727 4165 0.439773045083156 3650 0.139307783731572 -0.142053250310285 -1 1.95117155385578e-10 4398 4210 4014 4019 3823 3695 4431 4311 4458 3650 4165 4563 M15257 GO_REGULATION_OF_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ASSEMBLY.html Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 12/28 Gene Ontology BP GO:0090169 0.975244076969826 0.999999998379914 4145 3821.45454545455 4167 0.285551663400646 2528 0.188512058821541 -0.19110969454781 -1 3.26528399432116e-10 4141 4372 2882 4167 4541 2528 4440 2878 4585 4223 3279 4564 M12249 GO_EPITHELIAL_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_CELL_ADHESION.html The attachment of an epithelial cell to another epithelial cell via adhesion molecules. 9/22 Gene Ontology BP GO:0090136 0.999634917145749 0.999999998379914 4640 4146.09090909091 4170 0.546852963925785 3447 0.117637900135187 0.103132304567742 1 1.37242786612993e-10 4639 4630 3877 4296 4017 3710 3680 4507 4634 3447 4170 4565 M16176 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition. 25/44 Gene Ontology BP GO:1902808 0.9927223960657 0.999999998379914 4435 3930.54545454545 4170 0.360802142537963 2582 0.989745402399581 -0.989745402399581 -1 2.46640486867458e-09 3893 4170 2582 4211 3648 3791 4480 3202 4390 4435 4434 4566 M12589 GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. 12/36 Gene Ontology BP GO:0042088 0.999657585467162 0.999999998379914 4625 4026.18181818182 4172 0.515873015873016 2872 0.653874098340854 0.653874098340854 1 1.56938391215837e-09 4622 4228 2872 3803 4620 3565 4172 4435 4319 3531 4121 4567 M12405 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY.html Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. 10/23 Gene Ontology BP GO:0035794 0.703644047120782 0.789707350926225 3375 3866.45454545455 4174 0.104670159061015 2054 0.212467328358285 -0.121223991851913 -1 0.0826925762134925 3374 4345 3199 4493 4484 4213 4588 2054 4174 3479 4128 4568 M15199 GO_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 10/23 Gene Ontology BP GO:0009310 0.965461615042233 0.999999998379914 3695 3852.36363636364 4176 0.263592223582101 2094 0.801128877993451 0.801128877993451 1 1.9626614017782e-09 3693 3643 2094 3585 4176 4463 3836 4256 4205 4206 4219 4569 M15625 GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION.html The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. 2/15 Gene Ontology BP GO:0060573 0.83682970665955 0.905476655329828 4045 3920.8 4180.5 0.182447450612347 3082 0.287187081563147 -0.262762512201988 -1 0.0470087278093681 4043 3082 4432 NA 3135 4506 3302 3661 4345 4318 4384 4570 M15088 GO_REVERSE_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REVERSE_CHOLESTEROL_TRANSPORT.html The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. 8/24 Gene Ontology BP GO:0043691 0.879136193892288 0.937274247587117 4245 3903.09090909091 4181 0.19047619047619 2823 0.382074163365918 -0.358040929560912 -1 0.0408014704917326 4242 3668 4347 4238 4609 3108 2823 3744 3526 4181 4448 4571 M14333 GO_HISTONE_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_UBIQUITINATION.html The modification of histones by addition of ubiquitin groups. 24/40 Gene Ontology BP GO:0016574 0.963863016743717 0.999999998379914 4405 3830 4189 0.260556973320458 2590 0.185905345506623 -0.189663678686986 -1 3.19566576725457e-10 4248 4403 3296 4404 4189 2590 4413 2780 4513 3982 3312 4572 M13772 GO_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within an organism or cell. 46/109 Gene Ontology BP GO:0030104 0.0580563598530497 0.136553028772903 3380 3621 4193 0.00542250270351259 806 0.998542506531935 -0.998542506531935 -1 3.27746886914382 3377 4193 806 4426 4441 4461 4158 2388 4282 2718 4581 4573 M16721 GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. 9/30 Gene Ontology BP GO:0090025 0.562604368603265 0.670992058418947 4195 3998.45454545455 4193 0.0793650793650794 2891 0.989745402399581 -0.989745402399581 -1 0.651007106747 4192 3667 4610 3317 4354 3575 4198 4193 2891 4575 4411 4574 M11974 GO_PSEUDOURIDINE_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHESIS.html The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. 10/17 Gene Ontology BP GO:0001522 0.999803378079884 0.999999998379914 4205 4060 4194 0.53968253968254 3383 0.178910006176877 -0.195694300844316 -1 3.0088392685065e-10 4201 3855 3392 4320 4119 4450 3801 4194 4350 3383 4595 4575 M16295 GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. 14/20 Gene Ontology BP GO:0000028 0.999940849178077 0.999999998379914 4415 4179.36363636364 4195 0.587301587301587 3478 0.0929777484732146 -0.109873288114396 -1 7.13822246526603e-11 4268 4567 3478 4411 4106 4051 4195 3945 4414 4463 4075 4576 M16491 GO_PROTEIN_TARGETING_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_LYSOSOME.html The process of directing proteins towards the lysosome using signals contained within the protein. 16/25 Gene Ontology BP GO:0006622 0.999927061207498 0.999999998379914 4515 4073.45454545455 4198 0.579365079365079 3006 0.262025706345775 -0.30137972470192 -1 5.22863369470679e-10 4204 3753 3006 4198 4228 3916 4000 4513 4406 4515 4069 4577 M10139 GO_RESPONSE_TO_UV_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_C.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. 9/13 Gene Ontology BP GO:0010225 0.850419390042137 0.915455969875182 3780 3926.72727272727 4204 0.173034236664479 2962 0.209403155419009 -0.227368469115836 -1 0.0304928341386989 3778 4418 3541 4441 3091 4204 4207 3607 4518 2962 4427 4578 M15184 GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. 24/59 Gene Ontology BP GO:0030834 0.0839184282471183 0.158445571591463 4415 3036.72727272727 4204 0.00793650793650794 402 0.918246869629757 0.897743299739423 1 2.78882816938937 4411 402 1566 582 4559 3764 4618 4358 706 4204 4234 4579 M16878 GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. 3/21 Gene Ontology BP GO:0009713 0.985970995808246 0.999999998379914 3810 3970.72727272727 4204 0.347316423751591 2871 0.46896628455716 0.395417675398988 1 1.07554540323185e-09 3806 2871 4628 3726 3621 4514 4258 4204 4410 4617 3023 4580 M14895 GO_CELL_MIGRATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_IN_HINDBRAIN.html The orderly movement of a cell that will reside in the hindbrain. 5/24 Gene Ontology BP GO:0021535 0.926239790269015 0.972530833609008 4455 4001.54545454545 4206 0.229483019078807 3228 0.220918622131467 0.240811361959914 1 0.0101438685391144 4452 3228 4311 3384 3289 4206 4601 3753 4260 4125 4408 4581 M11095 GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. 5/24 Gene Ontology BP GO:0048172 0.997858238881248 0.999999998379914 4445 4073 4209 0.459149665032131 3164 0.200292071966945 0.096565267580736 1 3.57989612497274e-10 4443 4426 3688 4209 4199 4010 3197 4447 4539 3164 4481 4582 M14243 GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. 5/13 Gene Ontology BP GO:0052803 0.999705922249209 0.999999998379914 4425 4155.81818181818 4212 0.556548409586748 3485 0.452469120774559 0.29485168150683 1 1.03148596303184e-09 4064 4240 4212 4427 4032 4578 3485 3874 4422 3955 4425 4583 M15253 GO_VIRAL_LATENCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LATENCY.html The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. 5/16 Gene Ontology BP GO:0019042 0.999926988242722 0.999999998379914 4215 4192.72727272727 4213 0.614220380738673 3592 0.11045738254837 -0.101034049350131 -1 1.18065575948749e-10 4108 4212 4376 4213 4375 3592 4384 4036 4600 4222 4002 4584 M13892 GO_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BIOSYNTHETIC_PROCESS.html The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 63/137 Gene Ontology BP GO:0071897 0.99951171875 0.999999998379914 3750 3934 4214 0.5 2805 0.86730879294391 -0.759980613502947 -1 2.1394099655693e-09 3749 4444 3312 4224 4016 4226 3524 4214 4290 2805 4470 4585 M14250 GO_DNA_REPLICATION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_CHECKPOINT.html A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. 8/15 Gene Ontology BP GO:0000076 0.999995325897544 0.999999998379914 4165 4261.90909090909 4214 0.70693104025642 3864 0.096208850904683 -0.127011509782306 -1 8.00116209680146e-11 4161 4423 4214 4170 4438 3864 4335 4498 4642 3957 4179 4586 M14797 GO_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_REACTION.html The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg. 6/28 Gene Ontology BP GO:0007340 0.999881968939348 0.999999998379914 4415 4251.81818181818 4214 0.595238095238095 4059 0.216677204943187 -0.262755421399871 -1 4.01749848865737e-10 4413 4154 4293 4079 4637 4214 4243 4157 4423 4098 4059 4587 M11241 GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that activates or increases the frequency, rate or extent of viral release from host cell. 8/18 Gene Ontology BP GO:1902188 0.999754252664231 0.999999998379914 3225 3972.72727272727 4218 0.564439104713321 3197 0.188048352319104 0.203483318491192 1 3.25289965408928e-10 3225 4350 3715 4218 4270 4310 3553 4428 4505 3197 3929 4588 M14527 GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros. 8/26 Gene Ontology BP GO:0072010 0.650754332824389 0.74622187387099 4195 3878.72727272727 4219 0.0998536958480576 2707 0.487857430463018 -0.372195306042505 -1 0.235426376540208 4191 2758 4247 2991 2707 4256 4219 4559 4231 4036 4471 4589 M15461 GO_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECOMBINATIONAL_REPAIR.html A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. 48/92 Gene Ontology BP GO:0000725 0.999239669180019 0.999999998379914 3710 4021.54545454545 4219 0.479459192608057 3158 0.193765948301689 -0.21686238801214 -1 3.40560110119994e-10 3708 4608 3317 4475 4429 3158 3786 4219 4576 4280 3681 4590 M16612 GO_REGULATION_OF_GONADOTROPIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GONADOTROPIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. 2/14 Gene Ontology BP GO:0032276 0.995555607284292 0.999999998379914 4545 4188.7 4219.5 0.452169982285437 3772 0.325073401676685 -0.2001422664762 -1 6.91246626058705e-10 3772 4054 4592 NA 3848 4403 3838 4385 4543 4544 3908 4591 M13272 GO_PROTEIN_AUTOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOUBIQUITINATION.html The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. 27/55 Gene Ontology BP GO:0051865 0.789981140414661 0.866087942135837 3295 3799.18181818182 4222 0.132264994440978 1779 0.258528910596369 0.265723066197012 1 0.0612724693018208 3295 4222 3019 4442 4376 3588 1779 4508 4366 3691 4505 4592 M13134 GO_CELL_SEPARATION_AFTER_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SEPARATION_AFTER_CYTOKINESIS.html The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components. 10/17 Gene Ontology BP GO:0000920 0.969294434241629 0.999999998379914 3945 3963.81818181818 4223 0.271424971163074 2495 0.174310512927544 -0.163745657050324 -1 2.88599930617124e-10 3945 4347 2664 4223 4615 4480 2495 3963 4619 3655 4596 4593 M16080 GO_NEURONAL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ACTION_POTENTIAL.html An action potential that occurs in a neuron. 8/51 Gene Ontology BP GO:0019228 0.871555350247765 0.933310114403395 2385 3769.54545454545 4225 0.185536545735623 2119 0.224626413065397 -0.154800259672517 -1 0.0255571930616084 2382 4631 4504 4535 3941 2929 2119 4225 4629 4415 3155 4594 M14337 GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE.html Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. 6/12 Gene Ontology BP GO:0043097 0.99164548728797 0.999999998379914 3800 4066.72727272727 4226 0.380284851335832 3009 0.177053397496469 -0.162348862334857 -1 2.95925429729131e-10 3798 4639 4226 4582 3779 3009 4540 4433 4641 3984 3103 4595 M16248 GO_NEGATIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_KILLING.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. 21/80 Gene Ontology BP GO:0031342 0.856063535995083 0.919857208429801 4410 3948.09090909091 4232 0.161563694923294 2440 0.290288871759799 -0.243562335974582 -1 0.0399760532318412 4408 3883 2440 4437 3049 3566 4512 4618 4232 4453 3831 4596 M15169 GO_BLASTOCYST_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_GROWTH.html An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. 7/17 Gene Ontology BP GO:0001832 0.94339611337066 0.986193216998283 4520 4050.72727272727 4233 0.249614168533816 2414 0.168157770129538 0.148534836051848 1 0.00385404213222857 3609 4233 4366 4439 4262 4519 2414 3953 4519 4199 4045 4597 M11596 GO_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BINDING.html Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. 8/21 Gene Ontology BP GO:1900120 0.998887311640718 0.999999998379914 4620 4050 4234 0.493432463528988 3298 0.1922621598697 -0.153979983084714 -1 3.36543899978311e-10 4620 4234 3775 4354 4392 3819 3802 3489 4435 3298 4332 4598 M16580 GO_BONE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. 9/37 Gene Ontology BP GO:0070977 0.551419051588602 0.663134690230392 3860 3818.18181818182 4235 0.0770374436885589 2434 0.455185090209309 0.38608382523814 1 0.308237770530492 3859 2434 4585 2707 2535 4396 4616 4235 3753 4537 4343 4599 M13360 GO_MITOCHONDRIAL_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_PROCESSING.html The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. 7/12 Gene Ontology BP GO:0000963 0.991890981354985 0.999999998379914 4535 4111.72727272727 4239 0.382130397125262 2926 0.175249685509866 0.104980578775219 1 2.91108205298373e-10 4533 4239 4060 3960 4200 4603 2926 4324 4417 3716 4251 4600 M14613 GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. 4/13 Gene Ontology BP GO:0048484 0.90842312996039 0.959683411241431 4375 4130.27272727273 4257 0.212630514697895 3229 0.257817118781561 -0.202733941704214 -1 0.0174901055147376 4372 3728 4257 3961 3229 4300 4522 3884 4607 4054 4519 4601 M14903 GO_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_SLEEP.html Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. 7/36 Gene Ontology BP GO:0030431 0.666260997812057 0.758975695142582 4315 3905.72727272727 4261 0.103932561095981 2050 0.202175347258145 0.156926788847941 1 0.0919160189604362 4323 4308 4313 4261 4215 3072 4313 2050 3568 4126 4414 4602 M14479 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition. 17/33 Gene Ontology BP GO:1902750 0.978161938897681 0.999999998379914 4615 3922 4262 0.293650793650794 2152 1.33403223803043 -1.33403223803043 -1 3.38590142250795e-09 4611 4334 2685 4262 4636 3471 4537 4521 3904 2152 4029 4603 M15436 GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. 9/22 Gene Ontology BP GO:0044320 0.417217000746614 0.537081696819155 4280 3891.18181818182 4262 0.0525622445021328 2292 0.299196847275979 -0.262890832365965 -1 0.306593608123768 4277 3300 4404 3151 2292 3623 4262 4638 4036 4269 4551 4604 M13353 GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION.html Any recombinational process that contributes to the maintenance of proper telomeric length. 18/33 Gene Ontology BP GO:0000722 0.999995669416393 0.999999998379914 3915 4171.36363636364 4266 0.674603174603175 3255 0.179933015387225 -0.154251519360305 -1 3.03616106376861e-10 3911 4201 3255 3922 4469 4266 4479 4591 4511 3713 4567 4605 M13548 GO_BLASTOCYST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_DEVELOPMENT.html The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. 28/76 Gene Ontology BP GO:0001824 0.999590520100346 0.999999998379914 3845 3988.36363636364 4266 0.507936507936508 3042 0.281313097559979 -0.281727149239387 -1 5.74374748700155e-10 3842 4287 3042 4266 4337 3267 3834 4468 4303 3772 4454 4606 M10901 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. 9/29 Gene Ontology BP GO:2000144 0.987945623895701 0.999999998379914 4420 4017.09090909091 4267 0.357142857142857 3114 0.157267638610304 0.137743229510571 1 2.43083045914277e-10 4418 4346 3654 3866 4426 4380 4420 3246 4051 3114 4267 4607 M11707 GO_INSEMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSEMINATION.html The introduction of semen or sperm into the genital tract of a female. 6/18 Gene Ontology BP GO:0007320 0.935088995957999 0.980049256937469 3910 4096.27272727273 4269 0.239267741532064 3313 0.248938983785899 0.192444531518476 1 0.00827012778663499 3908 4480 3792 4199 3313 4548 4520 4269 4386 3319 4325 4608 M15439 GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 6/19 Gene Ontology BP GO:0050746 0.999167831171671 0.999999998379914 4250 4280.81818181818 4271 0.507936507936508 4007 0.264076361465988 0.213498278151166 1 5.28340111887163e-10 4250 4049 4405 4148 4243 4371 4007 4491 4307 4271 4547 4609 M15560 GO_EPITHELIAL_STRUCTURE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_STRUCTURE_MAINTENANCE.html A tissue homeostatic process required for the maintenance of epithelial structure. 13/49 Gene Ontology BP GO:0010669 0.930722389149555 0.975692944868229 3865 3895.63636363636 4271 0.215488426816453 2115 0.297132184161228 -0.195470893823045 -1 0.0120533019930432 3861 4623 2115 4294 3240 3850 4297 3448 4271 4305 4548 4610 M16780 GO_MITOTIC_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CHROMOSOME_CONDENSATION.html The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. 10/15 Gene Ontology BP GO:0007076 0.998966937543562 0.999999998379914 4105 4124.72727272727 4276 0.464749647845215 2813 0.189328128862623 -0.186774168079929 -1 3.28707900687477e-10 4105 4208 2813 4276 3872 4363 3534 4410 4604 4590 4597 4611 M15458 GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 8/32 Gene Ontology BP GO:0045408 0.173763274582984 0.274334942544153 4510 3371.72727272727 4278 0.0189063845736638 1581 0.365371287425964 -0.333955155006914 -1 0.779041622151279 4506 2138 4409 1581 1690 4311 4382 2207 3146 4278 4441 4612 M15471 GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 5/14 Gene Ontology BP GO:0003376 0.999886035595653 0.999999998379914 3345 4208.36363636364 4286 0.596654772606996 3343 0.226781880906516 0.250086028416825 1 4.28736691708155e-10 3343 4354 4412 4134 4589 4169 4558 3830 4551 4286 4066 4613 M16250 GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that increases the frequency, rate, or extent of monocyte chemotaxis. 8/23 Gene Ontology BP GO:0090026 0.562604368603265 0.670992058418947 4355 3866.81818181818 4286 0.0793650793650794 2686 0.989745402399581 -0.989745402399581 -1 0.651007106747 4353 3155 4535 2686 4390 3469 4286 4019 2870 4454 4318 4614 M16411 GO_NEGATIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_GROWTH.html Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 9/16 Gene Ontology BP GO:0061117 0.998228940920146 0.999999998379914 3870 4084.72727272727 4296 0.469331505113342 3240 0.311975534402736 0.259271901834891 1 6.56265782835651e-10 3869 3403 4560 3556 4296 4414 3240 4259 4479 4492 4364 4615 M15339 GO_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G2_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. 22/46 Gene Ontology BP GO:0031572 0.998050830608902 0.999999998379914 4300 4071.72727272727 4299 0.432948257478675 2846 0.217552890665672 -0.20974105146481 -1 4.04088567401375e-10 4299 4617 2846 4589 3982 3034 4543 4332 4547 4246 3754 4616 M10521 GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 19/37 Gene Ontology BP GO:0006221 0.991904637344142 0.999999998379914 4410 4009.90909090909 4307 0.354584093619795 2909 0.648828184364399 0.648828184364399 1 1.5559076475089e-09 4407 4405 2909 4142 3628 3883 4307 4448 4526 3039 4415 4617 M15180 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 19/31 Gene Ontology BP GO:0032205 0.999491648473943 0.999999998379914 4600 4150.81818181818 4308 0.498165660820704 2968 0.181636285836207 -0.160943890218237 -1 3.08165078762679e-10 4600 4621 2968 4595 3950 3744 4643 4308 4560 4203 3467 4618 M16540 GO_THYROID_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. 8/35 Gene Ontology BP GO:0030878 0.663427224845798 0.758360461288678 4515 4030.54545454545 4309 0.103174603174603 3113 0.344693672129807 -0.240367417885688 -1 0.157170659703028 4512 3113 4576 3249 4508 4309 3782 4262 3119 4525 4381 4619 M10569 GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 20/50 Gene Ontology BP GO:0090329 0.999122470374165 0.999999998379914 3390 3971.81818181818 4323 0.472630865702743 3040 0.194243342973161 0.16541667941143 1 3.41835101521953e-10 3386 4620 3040 4232 4400 4347 3252 4499 4541 3050 4323 4620 M14218 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. 39/67 Gene Ontology BP GO:0000288 0.999315513796142 0.999999998379914 4495 4122.09090909091 4324 0.484408342406863 3180 0.200906486336733 -0.187958163475382 -1 3.59630546268704e-10 4494 4544 3413 4227 4570 3180 4442 4556 4324 3948 3645 4621 M14528 GO_MITOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_RECOMBINATION.html The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. 24/43 Gene Ontology BP GO:0006312 0.999999915049891 0.999999998379914 4050 4192 4324 0.77238717889221 3087 0.189617880764264 -0.179054407324381 -1 3.29481749256322e-10 4436 4297 3087 4046 4444 4047 4346 4461 4587 4037 4324 4622 M15720 GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 6/17 Gene Ontology BP GO:0002283 0.521316976680343 0.634628925728063 4320 4020.54545454545 4325 0.071023340428817 2470 0.182356991962801 0.114513075638614 1 0.136695138801473 4319 4377 4447 4325 2470 3835 2786 4588 4284 4336 4459 4623 M11337 GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY.html The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. 4/34 Gene Ontology BP GO:0007214 0.910429076905555 0.961365068017397 4520 3986.18181818182 4331 0.214372449411496 2594 0.139970849073665 0.106704823193457 1 0.009091530963002 4519 4481 3732 4331 4642 3940 3187 2594 4636 3228 4558 4624 M16277 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. 22/34 Gene Ontology BP GO:0000291 0.999265597790827 0.999999998379914 4460 4078.45454545455 4341 0.481098523106418 3164 0.204627455690318 -0.162345591105868 -1 3.69568243977277e-10 3796 4458 3288 4499 4537 3164 4583 4207 4341 4458 3532 4625 M15478 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY.html The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. 87/229 Gene Ontology BP GO:0000184 0.972890055217184 0.999999998379914 4605 4006.81818181818 4342 0.279627461764593 2643 0.142914428439987 0.132278881377356 1 2.04749523042658e-10 3087 4601 3519 4484 3420 4579 2643 4342 4507 4289 4604 4626 M11708 GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/16 Gene Ontology BP GO:0032239 0.997257320977376 0.999999998379914 4375 4161.18181818182 4343 0.445607305819328 3320 0.154810683705427 0.142901925243479 1 2.36521187213466e-10 4374 4572 3793 4556 4158 4343 4416 3367 4621 3320 4253 4627 M16934 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. 6/21 Gene Ontology BP GO:0023019 0.754498481077359 0.834477476808523 4630 3985.72727272727 4343 0.13102872932046 1778 0.278281531524807 -0.220952200174622 -1 0.0830105663280075 4626 4310 4639 4343 2902 3426 1778 4543 4465 4633 4178 4628 M10697 GO_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_DNA_REPLICATION.html The DNA-dependent DNA replication that takes place as part of the cell cycle. 4/13 Gene Ontology BP GO:0044786 0.999984796638401 0.999999998379914 3860 4121 4345 0.670243046253698 3076 0.107440661951455 0.105785590129013 1 1.10008735240163e-10 3858 4380 3620 4345 4538 4399 3785 4366 4633 3076 4331 4629 M16777 GO_RESPONSE_TO_WATER_DEPRIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER_DEPRIVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. 4/17 Gene Ontology BP GO:0009414 0.997084784199292 0.999999998379914 3545 4140.90909090909 4348 0.442214691863303 3353 0.19893237817572 -0.0577563798190974 -1 3.54358239973228e-10 3542 4482 4618 4385 4388 4155 3805 3353 4348 4589 3885 4630 M15796 GO_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. 8/31 Gene Ontology BP GO:0032528 0.150511566660185 0.252618530181182 2640 3502.63636363636 4356 0.0161797736116416 624 0.152822445978186 0.174566677561943 1 0.346623160470921 2640 4636 4458 4461 4497 3184 624 2181 4630 4356 2862 4631 M15922 GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX.html The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. 6/16 Gene Ontology BP GO:0030150 0.994651672175528 0.999999998379914 4465 4185.36363636364 4378 0.407317912381035 3697 0.115001628999278 0.0849217936266156 1 1.30202023000879e-10 4260 3768 4480 3712 3751 3697 4454 4464 4612 4378 4463 4632 M14530 GO_STRAND_DISPLACEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRAND_DISPLACEMENT.html The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. 13/27 Gene Ontology BP GO:0000732 0.99999993266746 0.999999998379914 4235 4251.63636363636 4390 0.777145989433832 2931 0.182243593161612 -0.153313252804968 -1 3.097870315504e-10 4235 4516 2931 4507 4566 4066 4296 4615 4608 4038 4390 4633 M16319 GO_KINETOCHORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 5/12 Gene Ontology BP GO:0051383 0.94258750372258 0.986193216998283 4635 4225 4392 0.248549041010101 3338 0.222347844874995 -0.173401165615902 -1 0.00509603553309788 4631 3696 4549 4005 3338 3887 4619 4315 4573 4470 4392 4634 M14756 GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. 7/14 Gene Ontology BP GO:0046341 0.999583670542791 0.999999998379914 4425 4361.45454545455 4396 0.540861496855912 4004 0.166496043730875 0.110865551926953 1 2.67729607523857e-10 4423 4475 4287 4380 4004 4304 4562 4482 4572 4091 4396 4635 M15404 GO_ADULT_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. 6/29 Gene Ontology BP GO:0007512 0.999655428630466 0.999999998379914 4635 4344.45454545455 4399 0.549465639107466 3809 0.363722947199658 -0.512874820184311 -1 7.94469056421113e-10 4633 4424 4399 4334 4022 3809 4628 4451 4384 4262 4443 4636 M10449 GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any negative regulation of signal transduction that takes place in extracellular region. 3/15 Gene Ontology BP GO:1900116 0.999999998367093 0.999999998379914 4430 4243.45454545455 4425 0.867780308170204 3033 0.0662501222047987 0.0606818691840694 1 0 4427 4429 3588 4346 4503 4425 4348 4367 4638 3033 4574 4637 M13296 GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any regulation of signal transduction that takes place in the extracellular region. 3/15 Gene Ontology BP GO:1900115 0.999999998379914 0.999999998379914 4430 4346.63636363636 4426 0.867884487916357 3700 0.0662501222047987 0.0606818691840694 1 0 4428 4430 4047 4347 4504 4426 4349 4368 4639 3700 4575 4638 M10353 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. 9/23 Gene Ontology BP GO:0033962 0.994924422453255 0.999999998379914 4490 4023.36363636364 4447 0.410412120703877 3007 0.145205527474322 -0.11902485607636 -1 2.10868425796234e-10 4486 4633 3571 4550 3991 3208 4447 4579 4574 3007 3211 4639 M16659 GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 24/47 Gene Ontology BP GO:0072528 0.998522770590481 0.999999998379914 4645 4230.54545454545 4450 0.447061174210016 3011 0.648828184364399 0.648828184364399 1 1.5559076475089e-09 4643 4614 3011 4450 3838 3718 4625 4280 4594 4554 4209 4640 M16317 GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS.html The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. 7/16 Gene Ontology BP GO:0071428 0.758562172701605 0.838173290779047 4640 4013 4456 0.132477931501455 1781 0.0884288122540489 -0.0688420821641552 -1 0.0257338555302162 3948 4637 4547 4456 3440 3990 1781 3755 4637 4469 4483 4641 M15415 GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. 6/13 Gene Ontology BP GO:1904293 0.942372400311005 0.986193216998283 4645 4268.81818181818 4471 0.248267973649451 2411 0.0996588170036916 0.09231074975918 1 0.002284100622674 4135 4640 4401 4506 4330 4641 2411 4471 4643 4265 4514 4642 M13456 GO_DNA_REPLICATION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INITIATION.html The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. 15/31 Gene Ontology BP GO:0006270 0.999999995989524 0.999999998379914 4515 4275.72727272727 4490 0.827553584188619 2995 0.149627570399081 -0.152589662124827 -1 2.22678500447416e-10 4479 4513 2995 4302 4515 4255 4617 4510 4613 3744 4490 4643 M11745 GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. 11/25 Gene Ontology BP GO:0044818 0.999993387197551 0.999999998379914 3595 4140 4544 0.661837100200951 2981 0.143092223394767 -0.106886082869763 -1 2.05224365038604e-10 3595 4629 2981 4557 4554 4544 3756 4584 4597 3333 4410